\r\n\tHydroxyapatite (HA) is an important member of the calcium phosphate chemical family. It has been used in several medical applications for the past decades, due to its chemical similarity to the mineral phase of bone and high biocompatibility. Several studies demonstrated that bone mineral presents several ion substitutions, so in order to prepare a synthetic material with an even closer composition to bone mineral, HA has been prepared with the incorporation of several ions like, silicon or fluoride. These ions induced not only structural changes on HA lattice, but also on its biocompatibility. \r\n\tSignificant advances in nanotechnologies resulted in the preparation of HA in different forms, with a wider range of applications, from support to drug and gene delivery. \r\n\tThis book aims to collect the most relevant information regarding HA properties, modifications and its application in the biomedical field.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"6a3c2d529bd0b7fb6d259f00b4562d77",bookSignature:"Dr. Claudia Manuela da Cunha Ferreira Botelho",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/8199.jpg",keywords:"Apatite, Chemical and Physical Structure, Hydrothermal Synthesis, Synthesis from Biogenic Sources, Mineralization, Bone Structure, Vascularization, Resorption, Silicon, Improved Bioactivity,Bone Substitute, Drug and Gene Carrier",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 4th 2019",dateEndSecondStepPublish:"February 17th 2020",dateEndThirdStepPublish:"April 17th 2020",dateEndFourthStepPublish:"July 6th 2020",dateEndFifthStepPublish:"September 4th 2020",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"258963",title:"Dr.",name:"Claudia Manuela",middleName:null,surname:"Da Cunha Ferreira Botelho",slug:"claudia-manuela-da-cunha-ferreira-botelho",fullName:"Claudia Manuela Da Cunha Ferreira Botelho",profilePictureURL:"https://mts.intechopen.com/storage/users/258963/images/system/258963.jpg",biography:"Claudia Botelho obtained a PhD in Science Engineering from Porto University, Portugal, in 2005. From 2001 to 2006 her research was carried out in the United Kingdom and Japan, where she focused on the development of custom-made ceramic prostheses for reconstructive surgery. In 2013 she was invited as a lecturer at Minho University, Portugal. Her work was distinguished with several international prizes, like the European Award on Biomaterials and Tissue Engineering Doctoral Award. Dr. Botelho has supervised many graduate and postgraduate theses. In 2015 she was elected president of the National Researcher Association of Science and Technology, collaborating development of new scientific policies. Currently, she is focusing on the characterisation of natural molecules that can be encapsulated into new developed cubosomes.",institutionString:"University of Minho",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Minho",institutionURL:null,country:{name:"Portugal"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"8",title:"Chemistry",slug:"chemistry"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"43825",title:"Generalized Path Integral Technique: Nanoparticles Incident on a Slit Grating, Matter Wave Interference",doi:"10.5772/53471",slug:"generalized-path-integral-technique-nanoparticles-incident-on-a-slit-grating-matter-wave-interferenc",body:'
1. Introduction
One of the crises of contemporary mathematics belongs in part to the subject of the infinite and infinitesimals [1]. It originates from the barest necessity to develop a rigorous language for description of observable physical phenomena. It was a time when foundations of integral and differential calculi were developed. A theoretical foundation for facilitation of understanding of classical mechanics is provided by the concepts of absolute time and space originally formulated by Sir Isaac Newton [2]. Space is distinct from body. And time passes uniformly without regard to whether anything happens in the world. For this reason Newton spoke of absolute space and absolute time as of a "container" for all possible objects and events. The space-time container is absolutely empty until prescribed metric and a reference frame are introduced. Infinitesimals are main tools of differential calculus [3, 4] within chosen reference frames.
Infinitesimal increment being a cornerstone of theoretical physics has one receptee default belief, that increment δV tending to zero contains a lot of events to be under consideration. Probability of detection of a particle within this infinitesimal volume ρ(r→)δV is adopted as a smooth differentiable function with respect to its argument. From experience we know that for reproducing the probability one needs to accumulate enormous amount of events occurring within this volume. On the other hand we know, that as δV tends to zero we lose information about amount of the events. What is more, the information becomes uncertain. It means the infinitesimal increment being applied in physics faces with a conflict of depth of understanding physical processes on such minuscule scales. This trouble is avoided in quantum mechanics by proclamation that infinitesimal increments are operators, whereas observables are averaged on an ensemble.
In light of classical views Newton maintained the theory that light was made up of tiny particles, corpuscles. They spread through space in accordance with law of classical mechanics. Christian Huygens (a contemporary of Newton), believed that light was made up of waves vibrating up and down perpendicularly to direction of the light propagation. It comes into contradiction with Newtonian idea about corpuscular nature of light. Huygens was a proclaimer of wave mechanics as opposite to classical mechanics [5].
We abstain from allusion to physical vacuum but expand Huygensian idea to its logical completion. Let us imagine that all Newtonian absolute space is not empty but is populated everywhere densely by Huygensian vibrators. The vibrators are silent at absence of wave propagating through. But as soon as a wave front reaches some surface all vibrators on this surface begin to radiate at a frequency resonant with that of incident wave. From here it follows, that in each point of the space there are vibrators with different frequencies ranging from zero frequency up to infinite. All are silent in absence of an external wave perturbance. Thus, the infinitesimal volume δV is populated by infinite amount of the vibrators with frequencies ranging from zero to infinity. They are virtual vibrators facilitating propagation of waves through space.
Let us return to our days. One believes that besides matter and physical fields there is nothing more in the universe. Elementary particles are only a building material of "eternal and indestructible" substance of the cosmos. However we should avow that all observed matter and physical fields, are not the basis of the world, but they are only a small part of the total quantum reality. Physical vacuum in this picture constitutes a basic part of this reality. In particular, modern conception of the physical vacuum covers Huygens\'s idea perfectly. All space is fully populated by virtual particle-antiparticle pairs situated on a ground level. Such a particle-antiparticle pair has zero mass, zero charge, and zero magnetic moment. Famous Dirac’ sea (Dirac postulated that the entire universe is entirely filled by particles with negative energy) is boundless space of electron-positron pairs populated everywhere densely - each quantum state possessing a positive energy is accompanied by a corresponding state with negative energy. Electron has positive mass and positron has the same mass but negative; electron has negative charge and positron has the same positive charge; when electron and positron dance in pair theirs magnetic moments have opposite orientations, so magnetic moment of the pair is zero.
Let electron and positron of a virtual pair rotate about mass center of this pair. Rotation of the pairs happens on a Bohr orbit. Energy level of the first Bohr orbit, for example, mv 2/2, is about 14 eV. Here m is electron mass and v is its velocity (on the first Bohr orbit the velocity is about 2.188 106 m/s). Energy of the pair remains zero since positron has the same energy but with negative sign. Quantum fluctuations around this zero energy are as zero oscillations of electromagnetic field. Observe that, energy releasing of electron and positron from vacuum occurs at mc2 = 1.022 MeV. So we see that there are about 7.5 104 Bohr orbits lying below this energy. That is, there is a vast scope for occupation of different Bohr orbits by the virtual electron-positron pairs.
A short outline given above is a basis for understanding of interference effects to be described below.
Ones suppose that random fluctuations of electron-positron pairs take place always. What is more, these fluctuations are induced by other pairs and by particles traveling through this random conglomerate. Edward Nelson has described mathematical models [6, 7] representing the above random fluctuations as Brownian motions of particles that are subjected by random impacts from particles populating aether (Nelson\'s title of a lower environment). The model is viewed as a Markov process
dx(t)=b(x(t),t)dt+dw(t)E1
loaded by a Wiener term w with diffusion coefficient equal to ћ/2m, where m is a mass of the particle and ћ is the reduced Planck constant. In this perspective Nelson has considered two Markov processes complementary to each other. One is described by forward-difference operator in the time, here b(x(t),t) is a velocity calculated forward. And other equation is described by backward-difference operator in the time with the velocity b†(x(t),t) calculated backward. In general b(x(t),t) ≠ b†(x(t),t) [6, 7]. The two complementary processes, by means of transition to two new variables, real and imaginary, finally lead to emergence of the Schrödinger equation.
Nelson\' vision that aether fluctuations look as Brownian movements of subparticles with ћ/2m being the diffusion coefficient of the movements, correlates with Feynman\'s ideas about quantum fluctuations of virtual particles in vacuum [8]. The Feynman path integral is akin to the Einstein-Smoluchowski integral equation [9]. The latter computes transition probability density. We shall deal with the modified Feynman path integral loaded by a temperature multiplied by the Boltzmann constant. At that, probability amplitude stays as a fundamental mathematical object at all stages of computations. As an example we shall consider emergence of interference patterns at scattering heavy particles on gratings. The particles are heavy in the sense that they adjoin to both realms, quantum and classical. They are nanoparticles. Such nanoparticles have masses about 100 amu and more, as, for example, fullerene molecules [10] shown in Fig. 1. It is remarkable that there are many experiments with such molecules showing interference patterns in the near field [11-18]. On the other hand these molecules are so large, that they behave themselves as classical particles at ordinary conditions.
Figure 1.
The fullerene molecule C60 consists of 60 carbon atoms. Its radius is about 700 pm. De Broglie wavelength of the molecule, λdB, is about 5 pm at a flight velocity v =100 m/s [18]. The molecules are prepared in a thermal emission gun which has temperature about 1000 K. It means that carbon atoms accomplish thermal fluctuations.
The article consists of five sections. Sec. 2 introduces a general conception of the path integral that describes transitions along paths both of classical and quantum particles. Here we fulfill expansions in the Taylor series of terms presented in the path integral. Depending on type of presented parameters we disclose either the Schrödinger equation or diffusion-drift equation containing extra term, osmotic diffusion. In the end of the section we compute passing nanoparticles through N-slit grating. Sec. 3 deals with interference patterns from the N-slit grating. Specifically, we study blurring of the Talbot carpet (an interference pattern emergent under special conditions imposed on the grating [19, 20]) arising under decoherence of incident on the grating nanoparticles. In Sec. 4 we find equations for computing the Bohmian trajectories. Also we compute variance of momenta along the trajectories. These computations lead to emergence of the uncertainty conditions. In concluding Sec. 5 we summarize results. For confirmation of existence of the Bohmian trajectories here we mention interference experiments with single silicon oil droplet [21].
2. Generalized path integral
Let many classical particles occupy a volume V and they move with different velocities in different directions. Let us imagine that there is a predominant orientation along which ensemble of the particles drifts. As a rule, one chooses a small volume δV in order to evaluate such a drift, Fig. 2. Learning of statistical mechanics begins with assumption that the volume should contain many particles.
Figure 2.
Infinitesimal volume δV contains many particles moving with different velocities having predominant orientation along blue arrow. The infinitesimal volume δV, as a mental image, is shifted along the same orientation.
The problem is to find transition probabilities that describe transition of the particle ensemble from one statistical state to another. These transient probabilities can be found through solution of the integral Einstein-Smoluchowski equation [9]. This equation in mathematical physics is known as Chapman-Kolmogorov [22-24] equation.. This equation looks as follows
This equation describes a Markovian process without memory. That is, only previous state bears information for the next state. Integration here is fulfilled over all a working scene R, encompassing finite space volume. Infinitesimal volume δV in the integral tends to zero. It should be noted, however, that this volume should contain as many particles as possible for getting a satisfactory statistical pattern. One can see that this claim enters in conflict with the assumption δV → 0.
Next we shall slightly modify approach to this problem. Essential difference from the classical probability theory is that instead of the probabilities we shall deal with probability amplitudes. The transition amplitudes can contain also imaginary terms. They bear information about phase shifts accumulated along paths. In that way, a transition from an initial state q→0 to a final state q→1 through all intermediate positions q→x given on a manifold R3 (see Fig. 2) is represented by the following path integral
Here function ψ(...) is a probability amplitude. Probability density p(...), in turn, is represented by square of modulo of the probability amplitude, namely, p(...)=|ψ(...)|2. Integral kernel K(q→1,q→x;t+δt,t) represents the transition amplitude from an intermediate state q→x to a final state q→1. It is called propagator [8, 25, 26]. We suppose that the propagator has the following standard form
K(q→1,q→x;t+δt,t)=1Aexp{−L(q→x,q→˙x)δtΓ},E4
where denominator Γ under exponent is a complex-valued quantity, i.e., Γ = β+iћ. The both parameters, β and the reduced Planck constant ћ, have dimensionality of energy multiplied by time. From here it follows that β = 2kBTδt. Here kB is Boltzmann constant and T is temperature. So, we can write
Γ=2kBTδt+iℏ.E5
Factor 2 at the first term is conditioned by the fact that the kernel K relates to transitions of the probability amplitude ψ, not the probability p. Observe that a fullerene molecular beam for interference experiment prepared in a Knudsen cell at T=1070 K [27] spreads further in a vacuum. That is, fullerene molecules keep this temperature. From here it follows, that thermal fluctuations of carbon atoms from equilibrium occur at that temperature as the fullerene molecules propagate further within the vacuum chamber. One can see that at T=1000 K the term 2kBTδt may be about ћ if δt is about 10-14 s.
Next let us imagine that particles pass through a path length one by one. That is, they do not collide with each other along the path length. The particles are complex objects, however. They are nanoparticles. Fullerene molecule, for example, contains 60 carbon atoms, Fig. 1. Conditionally we can think that the atoms are connected with each other by springs simulating elastic vibrations. In this view the Lagrangian L(q→x,q→˙x) can be written in the following form
Here N is amount of atoms, constituent complex molecule, and m is mass of a single atom. By supposing that there are no quantum permutations between atoms we may expand the Lagrangian further
Here we admit that q→x and q→1 are coordinates of center of mass of that complex molecule in intermediate and final positions. And mN = Nm is a mass of the molecule referred to its center of mass. Small deviations δ→1,k=(q→1−q→1,k) and δ→x,k=(q→x−q→x,k) are due to oscillations of the kth atoms with respect to the center of mass.
Let us consider the second row in Eq. (7). First of all we note that the term (q→1−q→x)/δt represents a velocity of movement of the center of mass. In such a case the first term is a kinetic energy of the center of mass. The second term represents product of the center mass velocity on an averaged velocity of partial oscillations of atoms constituting this molecule. The averaged velocity we believe vanishes because of conservation of total momentum. The third term represents a thermal kinetic energy of partial oscillating atoms constituting this molecular object. This energy is small enough. But it is sufficient to exhibit itself in the Casimir effect. The last term is a total potential energy U(q→x)in the point q→x.
The path integral (3) contains functions depending only on coordinates q→0, q→1, q→xrelating to positions of the center of mass. Whereas the Lagrangian (6) gives description for behavior of each atom constituent the complex molecule. Here we shall suppose that oscillations of all atoms are noncoherent. And consequently they do not give contribution to interference effect on output. We believe that these oscillations provide a thermal noise. And next we shall replace this oscillating background by a corresponding thermal term. For this reason, we believe that along with the reduced Planck constant ћ the parameter 2kBTδt in Eq. (5) can be different from zero as well.
2.1. Expansion of the path integral
The next step is to expand terms, ingoing into the integral (3), into Taylor series. The wave function written on the left is expanded up to the first term
ψ(q→1,q→0;t+δt)≈ψ(q→1,q→0;t)+∂ψ∂tδt.E8
As for the terms under the integral, here we preliminarily make some transformations. We define a small increment
ξ→=q→1−q→x⇒D3qx=−D3ξ.E9
The Lagrangian (7) is rewritten, in such a case, in the following view
Here U(q→x)is sum of all potentials U(q→x,k) given in the center of mass. Further we shall deal with the path integral (3) where the kernel K contains the Lagrangian given from Eq. (10). The under integral function ψ(q→x,q→0;t)=ψ(q→1−ξ→,q→0;t)is subjected to expansion into the Taylor series up to the second terms of the expansion
ψ(q→1−ξ→,q→0;t)≈ψ(q→1,q→0;t)−(∇ψ,ξ→)+∇2ψ⋅ξ2/2E11
The potential energy U(q→x)=U(q→1−ξ→) is subjected to expansion into the Taylor series by the small parameter ξ→also. Here we restrict themselves by the first two terms of the expansion,U(q→1)−(∇U(q→1),ξ→).
Taking into account the expressions (8)-(11) and substituting theirs into Eq. (3) we get
First, we consider terms enveloped by braces (a) and (b): (a) here displacement (δ→1,k−δ→x,k) divided by δt is a velocity v→k of kth atom at its deviation from a steady position relative to the center of mass. Summation through all deviations of atoms divided by N gives averaged velocity, v→, of all atoms with respect to the center of mass. This averaged velocity, as we mentioned above, vanishes. The velocity can be nonzero only in a case when external forces push coherently all atoms. This case we do not consider here. (b) this term is a thermal kinetic energy, TN, of the atoms oscillating about the center of mass. Observe that energy of thermal fluctuations, TN, is proportional to kBT. Because of its presence in the propagator intensity of an interference pattern diminishes in general. Further we shall add this term into the potential energy as some constant component.
In the light of the above observation we rewrite Eq. (12) as follows
Here we have expanded preliminarily exponents to the Taylor series up to the first term of the expansion. Exception relates to the term exp{ -mN\n\t\t\t\t\tξ 2/2Γδt} which remains in its original form. This exponent integrated over all space R 3 results in
We note that the term (v→,∇ψ) here is absent since we consider v→=0, as was mentioned above. By reducing from the both sides the function ψ(q→1,q→0;t) we come to the following differential equation
is the diffusion coefficient. The coefficient has dimensionality of [length2 time-1]. It is a factor of proportionality representing amount of substance diffusing across a unit area in a unit time - concentration gradient in unit time.
We can see that Eq. (20) deals with the amplitude function ψ, not a concentration. However, a measurable function is ρ=|ψ|2 - concentration having dimensionality of [(amount of substance) length-3]. Let us multiply Eq. (20) from the left by 2ψ. First we note that the combination 2ψΔψ=2ψ∇ψ−1ψ∇ψ=2(ψ∇ψ−1)(ψ∇ψ)+2∇(ψ∇ψ) results in −(1/2)(∇ln(ρ)⋅∇ρ)+Δρ. As a result we come to a diffusion-drift equation describing diffusion in a space loaded by a potential field (U(q→1)−TN):
∂ρ∂t+D2(∇ln(ρ),∇ρ)=DΔρ+(U(q→1)−TN)2mNDρE22
Extra term (D/2)∇ln(ρ) in this diffusion-drift equation is a velocity of outflow of the particles from volume populated by much more number of particles than in adjacent volume. The term −ln(ρ) is entropy of a particle ensemble. From here it follows that ∇ln(ρ) describes inflow of the particles to a region where the entropy is small. Observe that the velocity
u→=D∇ρρ=D∇ln(ρ)E23
is an osmotic velocity required of the particle to counteract osmotic effects [6]. Namely, imagine a suspension of many Brownian particles within a physical volume acted on by an external, virtual in general, force. This force is balanced by an osmotic pressure force of the suspension [6]:
K→=kBT∇ρρ.E24
From here it is seen, that the osmotic pressure force arises always when density difference exists and especially when the density tends to zero. And vice-versa, the force disappears in extra-dense media with spatially homogeneous distribution of particles. As states the second law of thermodynamics spontaneous processes happen with increasing entropy. The osmosis evolves spontaneously because it leads to increase of disorder, i.e., with increase of entropy. When the entropy gradient becomes zero the system achieves equilibrium, osmotic forces vanish.
Due to appearance of the term (D/2)∇ln(ρ) in Eq. (22) the diffusion equation becomes nonlinear. It is interesting to note, running ahead, that this osmotic term reveals many common with the quantum potential, which is show further. Observe that the both expressions contain the term ∇ρ/ρ=∇ln(ρ) relating to gradient of the quantum entropy SQ=−ln(ρ)/2 [28].
Reduction to PDEs, Eq. (19) and Eq. (22), was done with aim to show that the both quantum and classical realms adjoin with each other much more closely, than it could seem with the first glance. Further we shall return to the integral path paradigm [8] and calculate patterns arising after passing particles through gratings. We shall combine quantum and classical realms by introducing the complex-valued parameter Γ = 2kBTδt + iћ.
2.2. Paths through N-slit grating
Computation of a passing particle through a grating is based on the path integral technique [8]. We begin with writing the path integral that describes passing the particle through a slit made in an opaque screen that is situated perpendicularly to axis z, Fig. 3. For this reason we need to describe a movement of the particle from a source to the screen and its possible deflection at passing through the slit, see Fig. 4. At that we need to evaluate all possible deflections.
Figure 3.
Interferometry from one grating G0 situated transversely to a particle beam emitted from a distributed source.
We believe, that before the screen and after it, the particle (fullerene molecule, for example) moves as a free particle. Its Lagrangian, rewritten from Eq. (17), describes its deflection from a straight path in the following form
L=mNx˙22−mN(x˙,v→)+TN.E25
The first term relates to movement of the center of mass of the molecule. So that mN is mass of the molecule and x˙ is its transversal velocity, i.e., the velocity lies in transversal direction to the axis z. The second term is conditioned by collective fluctuations of atoms constituent this molecule. This term is nonzero when atoms have predominant fluctuations along axis x. For the sake of simplicity we admit that v→ is constant. The third term is a constant and comes from Eq. (17). It can be introduced into the normalization factor. For that reason we shall ignore this term in the following computations. A longitudinal momentum, pz, is much greater than its transverse component [16, 17, 29] and we believe it is constant also. By translating a particle\'s position on a small distance δx = (xb - xa)<< 1 for a small time δt = (tb - ta)<< 1 we find that a weight factor of such a translation has the following form
Figure 4.
Passage of a particle along path (zs,xs) → (z0,x0) → (z1,x1) through a screen containing one slit with a width equal to 2b0. Divergence angle of particles incident on the slit, α, tends to zero as the source is removed to infinity.
The particles flying to the grating slit along a ray α, Fig. 4, pass through the slit within a range from x0-b0 to x0+b0 with high probability. The path integral in that case reads
Here v(a,b) = (xb\n\t\t\t\t\t– xa)/(tb\n\t\t\t\t\t– tb) is a velocity of the molecule on a segment from xa to xb. And v is an average velocity of collective deflection of atoms constituent the molecule. It was defined in Eq. (12). We shall believe that the ratio v/v (a,b) is small enough. We can define a new renormalized mass {m}N = mN (1 - v/v(a,b)) and further we shall deal with this mass.
2.2.1. Passing of a particle through slit
By substituting the kernel (28) into the integral (27) we obtain the following detailed form
The integral is computed within a finite interval [-b0,+b0]. Observe, that the integrating can be broadened from -∞ to +∞. But in this case we need to load the integral by the step function equal to unit within the finite interval [-b0,+b0] and it vanishes outside of the interval. The step function, that simulate a single slit, can be approximated by the following a set of the Gaussian functions [30]
Here parameter b is a half-width of the slit, real η > 0 is a tuning parameter, and K takes integer values. At K = 1 this form-factor degenerates to a single Gaussian function. And at K → ∞ this function tends to an infinite collection of the Kronecker deltas which fill everywhere densely the step function. We rewrite Eq. (29) with inserting this form-factor
We do not write parameters η and K in the Gaussian form-factor and for the sake of simplicity further we shall consider they equal to 1. That is, for simulating the slit we select a single Gaussian function.
2.2.2. Definition of new working parameters
First we replace the flight times τ0 and τ1 by flight distances (z0-zs) and (z1-z0), see Fig. 4. This replacement reads
{τ0=(z0−zs)/vzτ1=(z1−z0)/vzE32
where vz is a particle velocity along the axis z.
There is, however, one more parameter of time that is represented in definition of the coefficient Γ= 2kBTδt + iћ. It is a small time increment δt. The parameter δt first appears in the path integral (3) as the time increment along a path. In accordance with the uncertainty principle δt should be more or equal to the ratio of ћ, Planck constant, to energy of occurring events. In a case of a flying particle through vacuum it can be minimal energy of vacuum fluctuations (it is about energy of the first Bohr orbit of electron-positron pair that is about 14 eV). Evaluation gives δt ~ 2.8 10-16 s. From here it follows, that 2kBTδt is less than ћ on about one order at T = 1000 K (almost temperature of fullerene evaporation from the Knudsen cell [27]).
Emergence of the term 2kBTδt can be induced by existence of quantum drag [31] owing to different conditions for quantum fluctuations both inside of the fullerene molecule and outside what can induce weak Casimir forces. Because of the weak Casimir force the quantum drag does not lead to decoherence at least in the near zone. However further we shall see that a weak washing out of the Talbot interference pattern is due to existence of this term.
Let us divide the parameter Γ by {m}N\n\t\t\t\t\t\tvz
Γ{m}Nvz=2kBT{m}Nvzδt+iℏ{m}Nvz.E33
Here pz = {m}N\n\t\t\t\t\t\tvz is a particle momentum along axis z. We can define the de Broglie wavelength λdB = h/pz where h = 2πћ is the Planck constant. Let us also define a length δT = 4πkBTδt/({m}N\n\t\t\t\t\t\tvz). In this view we can rewrite Eq. (33) as follows
Γ{m}Nvz=δT2π+iλdB2π=12πΛ.E34
The length δT tends to zero as T → 0. At T = 1000 K and at adopted δt = 2.8 10-16 s we have δT ≈ 0.4 pm. On the other hand, the de Broglie wavelength, λdB, evaluated for the fullerene molecule moving with the velocity vz =100 m/s is about 5 pm [18]. So, we can see that the length δT is less of the de Broglie wavelength on about one order and smaller. A signification of the length δT is that it determines decoherence of a particle beam. Decoherence of flying particles occurs the quickly, the larger δT. Observe that the length δT has a close relation with the coherence width - a main parameter in the generalized Gaussian Schell-model [32, 33].
3. Wave function behind the grating
Wave function from one slit after integration over ξ0 from -∞ to +∞ has the following view [28]
Here argument of ψ-function contains apart x also z in order to emphasize that we carry out observation in the point (z,x), see Fig. 4. The factor (2/π)1/2 comes from (30). Parameters Ξ0 and Σ0 read
In order to simplify records here we omit subscript 1 at x and z - an observation point that is situated after the slit.
Let us consider that an opaque screen contains N0 slits spaced through equal distance, d, from each other. Numeration of the slits is given as it is shown in Fig. 3, n0 = 0,1,2, …, N0 – 1. Sum of all wave functions (35), each of which calculates outcome from an individual slit, gives a total effect in the point (z,x) where a detector is placed:
Probability density in the vicinity of the observation point (x,z) reads
p(x,z)=〈Ψ0(x,z,d,xs,Λ)|Ψ0(x,z,d,xs,Λ)〉.E38
Calculation of the wave function (37) is fulfilled for the grating containing N0 = 32 slits. Distance between slits is d = 105λdB. So at λdB = 5 pm the distance is equal to 500 nm. Requirement λdB << d and N0 tending to infinity together with a condition that the particle beam is paraxial, that is, xs = 0 and zs → -∞, provides emergence in the near-field of an interference pattern, named Talbot carpet [19,20]. Here a spacing along interference patterns is measured in the Talbot length
zT=2d2λdB,E39
which is a convenient natural length at representation of interference patterns. Since we restrict themselves by finite N0 we have a defective carpet, which progressively collapses as a spacing from the slit increases. Fig. 5 shows the Talbot carpet, being perfect in the vicinity of the grating slit; it is destroyed progressively with increasing zT. As for the Talbot carpet we have the following observation. We see that in a cross-section z = zT/2 image reproduces radiation of the slits but phase-shifted by half period between them. At z = zT radiation of the slits is reproduced again on the same positions where the slits are placed. And so forth.
Evaluation of sizes of the interference pattern is given by ratio of the Talbot length to a length of the slit grating. In our case the Talbot length is zT = 0.1 m. And length of the slit grating is about N0d = 1.6 10-5 m. From here we find that the ratio is 6250. It means that the interference pattern shown in Fig. 5 represents itself a very narrow strip.
Figure 5.
Interference pattern in the near field. It is shown only the central part of the grating containing N0 = 32 slits, λdB = 5 pm, d = 500 nm, and δT = 0. In the upper part of the figure a set of the Bohmian trajectories, looking like on zigzag curves, drawn in dark blue color is shown.
Zigzag curves, drawn in the upper part of Fig. 5 by dark blue color, show Bohmian trajectories that start from the slit No. 15. One can see that particles prefer to move between nodes having positive interference effect and avoid empty lacunas. However the above we noted, that the ratio of the Talbot length to the length of the grating is about 6250 >> 1. It means that really the Bohmian trajectories look almost as straight lines slightly divergent apart. Zigzag-like behavior of the trajectories is almost invisible. Such an almost feebly marked zigzag-like behavior may be induced by fluctuations of virtual particles escorting the real particle.
As soon as we add the term kBTδt different from zero (T > 0 K) we observe blurring the interference pattern. The blurring is the stronger, the larger kBTδt. For comparison see Figs. 6 and 7. Here instead of kBTδt we write a more convenient parameter, the coherence length δT. This length characterizes a dispersed divergence from initially tuned the de Broglie wavelength. Such a disperse medium can be due to quantum drag on the vacuum fluctuations. Here the Bohmian trajectories are not shown, since because of the thermal term kBTδt > 0 a Brownian like scattering of the trajectories arises. This scattering we shall discuss later on.
Figure 6.
Blurred interference pattern in the near field. It is shown only the central part of the grating containing N0 = 32 slits; d = 500 nm, δT = 0.04 pm << λdB = 5 pm.
Figure 7.
Blurred interference pattern in the near field. It is shown only the central part of the grating containing N0 = 32 slits; d = 500 nm, δT = 0.4 pm < λdB = 5 pm.
Figure 8.
Destroyed interference pattern because of large δT = 4 pm ~ λdB = 5 pm. N0 = 32 slits, d = 500 nm.
We may think that the technical vacuum can be not perfect. It causes additional scattering of particles on residual gases. Because of this additional scattering the interference pattern can be destroyed entirely, as shown in Fig. 8.
Now let us draw dependence of the probability density p(x, z) as a function of x at fixed z. In other words, we calculate interference fringes in a cross-section of the interference patterns at z = zT/2 for different values of the length δT. Such a cross-section is chosen because a self image of the slit grating appears phase-shifted by half period of the grating. For that reason we should see the interference fringes spaced between the slit sources of radiation.
Fig. 9 shows three characteristic patterns of the interference fringes. In Fig. 9(a) almost ideal interference fringes are shown obtained at δT < λdB. Fig. 9(b) shows interference fringes obtained at δT ~ λdB. It is instructive to compare these interference fringes with those that have been measured in experiments [14, 34]. And Fig. 9(c) shows disappearance of interference fringes because of strong scattering of the particles on residual gases in vacuum, δT > λdB.
Figure 9.
Interference fringes in cross-section of the density distribution pattern by the Talbot half-length, z = zT/2, (the fringes are drawn in red): (a) δT = 0.4 pm, almost coherent beam; (b) δT = 4 pm, weak coherence; (c) δT = 40 pm, entirely noncoherent beam. Cyan strips show luminosity of slits. The grating consists of N0 = 9 slits. Collapse of the interference pattern on edges of the grating is due to its finite length. Therefore visibility of the interference fringes is evaluated only for 5 central slits.
Disappearance of interference fringes is numerically evaluated by calculating a characteristic called visibility [14, 34]. The fringe visibility [27] is represented as a ratio of difference between maximal and minimal intensities of the fringes to their sum:
V=Pmax−PminPmax+Pmin.E40
Evaluation of Pmax and Pmin is shown in Fig. 9(b). As follows from the figure, the evaluations are fulfilled in a central region of the grating. That is, edges of the grating have to be left far off from the measured zone. The visibility V as a function of the parameter δT is shown in Fig. 10. One can see that crossover from almost perfect interference fringes, V = 1, up to their absence, V = 0, begins near δT. ~ λdB. Transition from almost coherent particle beam to incoherent is a cause of such a crossover [30].
Figure 10.
Visibility of interference fringes as a function of the parameter δT ranging from 0.1 to 40 pm. Wavelength of a matter wave is λdB = 5 pm.
4. Bohmian trajectories and variance of momenta and positions along paths
Here we repeat computations of David Bohm [35] which lead to the Hamiltoton-Jacobi equation loaded by the quantum potential and, as consequence, to finding Bohmian trajectories. But instead of the Schrödinger equation we choose Eq. (17) that contains complex-valued parameter Γ=β+iћ:
(β−iℏ)∂ψ∂t=(β2+ℏ2)2mN∇2ψ+(β−iℏ)(β+iℏ)Vψ.E41
Here β = 2kBTδt (in particular, the diffusion coefficient reads D = β/2mN) and V=U(q→1)−TN.
Further we apply polar representation of the wave function, ψ = R exp{iS/ћ}. It leads to obtaining two equations for real and imaginary parts that deal with real-valued functions R and S. The function R is the amplitude of the wave function and S/ћ is its phase. After series of computations, aim of which is to put together real and imaginary terms, we obtain the following equations
Firstly, we can see that at β = 0 Eq. (42) reduces to the modified Hamilton-Jacobi equation due to loaded the quantum potential that is enveloped here by brace (b). And Eq. (43) reduces to the continuity equation. These equations read
∂S∂t=−12mN(∇S)2︸(a)+ℏ22mN∇2RR︸(b)+V,E44
−1R∂R∂t=12mN(∇2S+21R∇R∇S︸(c)).E45
Terms enveloped by braces (a), (b), and (c) are the kinetic energy of the particle, the quantum potential, and the right part is a kernel of the continuity equation (45), respectively. In particular, the term 2∇R/R=∇ln(R2) relates to the osmotic velocity, see Eq. (23). Eqs. (44) and (45) are the same equations obtained by Bohm [35]. From historical viewpoint it should be noted that the same equations were published by Madelung
My attention to the Madelung\' article was drawn by Prof. M. Berry.
where v→ is its current velocity. The de Broglie equation relates the momentum p to the wavelength λdB = h/p, where h = 2πћ is the Planck constant. Now, as soon as we found the current velocity
v→=1mN∇S=ℏmNIm(|ψ〉−1∇|ψ〉)E47
positions of the particle in each current time beginning from the grating\' slits up to a detector is calculated by the following formula
r→(t+δt)=r→(t)+v→(t)δt.E48
Here t is a current time that starts from t=0 on a slit source and δt is an arbitrarily small increment of time. Some calculated trajectories of particles, the Bohmian trajectories, are shown in upper part of Fig. 5. It should be noted that the Bohmian trajectories follow from exact solutions of Eqs. (44)-(45). These equations give a rule for finding geodesic trajectories and secants of equal phases, S/ћ, at given boundary conditions. The geodesic trajectories point to tendency of the particle migration along paths. And the secant surfaces describe a coherence of all the passing particles created on a single source.
In case of β >> ћ we have the following two equations
∂R∂t=−β2mNℏ2R(∇S)2︸(a)+β2mN∇2R︸(b),E49
∂S∂t=β2mN(∇2S+21R∇R∇S︸(c)),E50
Here we take into consideration that in the first equation we may replace (∇S/ℏ)2=4π2/λdB2. In the second equation we may replace the term ∇S by mNv→ as follows from Eq. (46). We notice also, that 2R−1∇R=2∇ln(R)=∇ln(ρ). And β/2mN =D is the diffusion coefficient. Now we may rewrite Eqs. (49)-(50) as follows
∂R∂t=D∇2R︸(b)−4π2λdB2DR︸(a),E51
∂S∂t=D(∇2S+mN(∇ln(ρ),v→))︸(c)=D∇2S+mN(u→,v→).E52
Here u→=D∇ln(ρ) is the osmotic velocity defined in Eq. (23). We got the two diffusion equations coupled with each other through sources. Namely, this coupling is provided due to the de Broglie wavelength and the osmotic velocity which can change with time. These diffusion equations cardinally differ from Eqs. (44)-(45). Because of diffusive nature of these supplementary parts blurring of interference patterns occurs. It leads to degeneration of the Bohmian trajectories to Brownian ones.
4.1. Dispersion of trajectories and the uncertainty principle
As for the Bohmian trajectories there is a problem concerning their possible existence. As follows from Eqs. (46) and (48) in each moment of time there are definite values of the momentum and the coordinate of a particle moving along the Bohmian trajectory. This statement enters in conflict with the uncertainty principle.
Here we try to retrace emergence of the uncertainty principle stemming from standard probability-theoretical computations of expectation value and variance of a particle momentum. We adopt a wave function in the polar representation
|Ψ〉=Rexp{iS/ℏ},E53
where R = (ρ)1/2 is the amplitude of the wave function (ρ =R2 = <Ψ|Ψ> is the probability density) and S/ћ is its phase. Momentum operator p^=−iℏ∇and corresponding velocity operator v^=−i(ℏ/m)∇are kinetic operators in quantum mechanics. Here m is mass of the particle. Expectation value of the velocity operator reads
V→g=1〈Ψ|Ψ〉〈Ψ|−iℏm∇|Ψ〉=1m(∇S+iℏ∇SQ).E54
The velocity V g is seen to be complex-valued. Here SQ=−ln(R)=−ln(ρ)/2 is the quantum entropy [28] and (ћ/2m) is the quantum diffusion coefficient [6, 7]. Therefore its imaginary part is a quantum osmotic velocity
u→Q=−(ℏ/m)∇SQ=(ℏ/2m)∇ln(ρ).E55
It is instructive to compare this velocity with the classical osmotic velocity given in Eq. (23). As can see the osmotic velocity stems from gradient of entropy that evaluates degree of order and disorder on a quantum level, likely of vacuum fluctuations.
Real part of Eq. (54) gives the current velocity v→ defined by Eq. (47). It should be noted that because of existence of imaginary unit in definition of the momentum operator, real part of Eq. (54) is taken as the current velocity. Whereas imaginary unit is absent in Eq. (47). Therefore at computing the current velocity by Eq. (47) we take imaginary part.
Let us now calculate variance of the velocity V g. This computation reads
Here the term enveloped by bracket (a) is a kinetic energy of the particle, the term enveloped by bracket (b) with negative sign added is the quantum potential Q, and the term enveloped by bracket (c) comes from the continuity equation. See for comparison Eqs. (44) and (45). We rewrite the quantum potential as follows
Q=−ℏ22m∇2RR=−ℏ22m(∇SQ)2+ℏ22m∇2SQ.E59
As for the second term in Eq. (57) we have i(ℏ/2)∇V→g=i(ℏ/2m)ΔS−(ℏ2/2m)ΔSQ. It is follows from computation by Eq. (54). As a result, the expression (57) takes the following view
m2Var(Vg)=12m(∇S)2−ℏ22m(∇SQ)2−iℏm(∇S,∇R)R.E60
One can see that the variance consists of real and imaginary parts. Observe that the right side is represented through square of gradient of the complexified action [28], namely (∇(S+iℏSQ))2/2m. We shall not consider here the imaginary part. Instead we shall consider the real part of this expression. It reads
m2Re(Var(Vg))=12m(∇S)2−ℏ(ℏ2m(∇SQ)2).E61
The first term in this expression represents kinetic energy, E, of the particle. The second term, stemming from the quantum potential, contains under braces a term having dimensionality of inverse time, that is, of frequency
ωQ=ℏ2m(∇SQ)2E62
This frequency multiplied by ћ represents an energy binding a particle with vacuum fluctuations. This energy, as follows from Eq. (61), is equal to the particle mass multiplied by squared the osmotic velocity (55) and divided by 2. It is an osmotic kinetic energy. In the light of the above said we rewrite Eq. (61) in the following way
m2Re(Var(Vg))=E−ℏωQ≥0.E63
Let we have two Bohmian trajectories. Along one trajectory we have E1 - ћωQ,1, and along other trajectory we have a perturbed value E2 - ћωQ,2. Subtracting one from other we have
δE−ℏδωQ≥0.E64
One can suppose that emergence of the second trajectory was conditioned by a perturbation of the particle moving along the first trajectory. If it is so, then emergence of the second trajectory stems from an operation of measurement of some parameters of the particle. One can think that duration of the measurement is about δt = 1/δωQ. From here we find
δEδt≥ℏE65
Now let us return to Eq. (48) and rewrite it in the following view
δr→(t)=v→1(t)δt≥v→1(t)ℏ/δE.E66
The initial Bohmian trajectory is marked here by subscript 1. Observe that δE=m(v22−v12)/2≈mv→1δv→. Here we have calculated v22=(v→1+δv→)2≈v12+2v→1δv→. Substituting computations of δE into Eq. (66) we obtain finally
δp→δr→≥ℏE67
Here we take into account δp→=mδv→.
5. Concluding remarks
Each nanoparticle incident on a slit grating passes only through a single slit. Its path runs along a Bohmian trajectory which is represented as an optimal path for the nanoparticle migrating from a source to a detector. Unfortunately, the Bohmian trajectory can not be observable since a serious obstacle for the observation comes from the uncertainty principle. In other words, an attempt to measure any attribute of the nanoparticle, be it position or orientation, i.e., the particle momentum, leads to destroying information relating to future history of the nanoparticle. What is more, any collision of the nanoparticle with a foreign particle destroys the Bohmian trajectory which could give a real contribution to the interference pattern. It relates closely with quality of vacuum. In the case of a bad vacuum such collisions will occur frequently. They lead to destruction of the Bohmian trajectories. Actually, they degenerate to Brownian trajectories.
Excellent article [21] of Couder & Fort with droplets gives, however, a clear hint of what happens when the nanoparticle passes through a single grating slit. In the light of this hint we may admit that the particle “bouncing at moving through vacuum” generates a wave at each bounce. So, a holistic quantum mechanical object is the particle + wave. Here the wave to be generated by the particle plays a role of the pilot-wave first formulated by Lui de Broglie and later developed by Bohm [37]. It is interesting to note in this context, that the pilot-waves have many common with Huygens waves [5].
A particle passing through vacuum generates waves with wavelength that is inversely proportional to its momentum (it follows from the de Broglie formula, λ = h/p, where h is Planck\'s constant). One can guess that a role of the vacuum in the experiment of Couder & Fort takes upon itself a silicon oil surface with subcritical Faraday ripples activated on it [21]. Observe that pattern of the ripples is changed in the vicinity of extraneous bodies immersed in the oil which simulate grating slits. Interference of the ripples with waves generated by the bouncing droplets provides optimal paths for the droplets traveling through the slits and further. As a result we may observe an interference pattern emergent depending on amount of slits in the grating and distance between them.
Now we may suppose that the subcritical Faraday ripples on the silicon oil surface simulate vacuum fluctuations. Consequently, the vacuum fluctuations change their own pattern near the slit grating depending on amount of slits and distance between them. We may imagine that the particle passing through vacuum (bouncing through, Fig. 11) initiates waves which interfere with the vacuum fluctuations. As a result of such an interference the particle moves along an optimal path - along the Bohmian trajectory. Mathematically the bounce is imitated by an exponential term exp{iS/ћ}, where the angle S/ћ parametrizes the group of rotation given on a circle of unit radius. So, the path along which the particle moves is scaled by this unitary group, U(1), due to the exponential mapping of the phase S/ћ on the circle.
Figure 11.
Bouncing a nanoparticle at moving through vacuum. Vertical dotted sinusoidal curves depict exchange by energy ΔE with vacuum virtual particle-antiparticle pairs over period of about Δt=ћ/ΔE.
In conclusion it would be like to remember remarkable reflection of Paul Dirac. In 1933 Paul Dirac drew attention to a special role of the action S in quantum mechanics [38] - it can exhibit itself in expressions through exp{iS/ћ}. In 1945 he emphasized once again, that the classical and quantum mechanics have many general points of crossing [39]. In particular, he had written in this article: "We can use the formal probability to set up a quantum picture rather close to the classical picture in which the coordinates q of a dynamical system have definite values at any time. We take a number of times t1, t2, t3, … following closely one after another and set up the formal probability for the q\'s at each of these times lying within specified small ranges, this being permissible since the q\'s at any time all commutate. We then get a formal probability for the trajectory of the system in quantum mechanics lying within certain limits. This enables us to speak of some trajectories being improbable and others being likely."
Acknowledgement
Author thanks Miss Pipa (administrator of Quantum Portal) for preparing programs that permitted to calculate and prepare Figures 5 to 8. Author thanks also O. A. Bykovsky for taking my attention to a single-particle interference observed for macroscopic objects by Couder and Fort and V. Lozovskiy for some remarks relating to the article.
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/43825.pdf",chapterXML:"https://mts.intechopen.com/source/xml/43825.xml",downloadPdfUrl:"/chapter/pdf-download/43825",previewPdfUrl:"/chapter/pdf-preview/43825",totalDownloads:2538,totalViews:162,totalCrossrefCites:4,totalDimensionsCites:4,totalAltmetricsMentions:0,introChapter:null,impactScore:1,impactScorePercentile:75,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"June 15th 2012",dateReviewed:"September 17th 2012",datePrePublished:null,datePublished:"April 3rd 2013",dateFinished:"March 19th 2013",readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/43825",risUrl:"/chapter/ris/43825",book:{id:"3513",slug:"advances-in-quantum-mechanics"},signatures:"Valeriy I. Sbitnev",authors:[{id:"93881",title:"Dr.",name:"Valeriy",middleName:null,surname:"Sbitnev",fullName:"Valeriy Sbitnev",slug:"valeriy-sbitnev",email:"valery.sbitnev@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Petersburg Nuclear Physics Institute",institutionURL:null,country:{name:"Russia"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Generalized path integral",level:"1"},{id:"sec_2_2",title:"2.1. Expansion of the path integral",level:"2"},{id:"sec_2_3",title:"2.1.1. Temperature is zero",level:"3"},{id:"sec_3_3",title:"2.1.2. Temperature is not zero",level:"3"},{id:"sec_5_2",title:"2.2. Paths through N-slit grating",level:"2"},{id:"sec_5_3",title:"2.2.1. Passing of a particle through slit",level:"3"},{id:"sec_6_3",title:"2.2.2. Definition of new working parameters",level:"3"},{id:"sec_9",title:"3. Wave function behind the grating",level:"1"},{id:"sec_10",title:"4. Bohmian trajectories and variance of momenta and positions along paths",level:"1"},{id:"sec_10_2",title:"4.1. Dispersion of trajectories and the uncertainty principle",level:"2"},{id:"sec_12",title:"5. Concluding remarks",level:"1"},{id:"sec_13",title:"Acknowledgement",level:"1"}],chapterReferences:[{id:"B1",body:'Dauben JW. Abraham Robinson: The creation of nonstandard analysis. A personal and mathematical odyssey. Princeton, NJ: Princeton University Press; 1995.'},{id:"B2",body:'Stanford Encyclopeia of Philosophy: Newton\'s Views on Space, Time, and Motion. http://plato.stanford.edu/entries/newton-stm/ (accessed 12 August 2004).'},{id:"B3",body:'Henson CW. Foundations of nonstandard analysis. In: Arkeryd L.O., Cutland N. J., & Henson C. W., (eds.) Nonstandard Analysis, Theory and application. The Netherlands: Kluwer Acad. Publ.; 1997,p. 1-51.'},{id:"B4",body:'Nelson E. Radically Elementary Probability Theory. Princeton, New Jersey: Princeton Univ. Press; 1987.'},{id:"B5",body:'Huygens C. Treatise on Light. Gutenberg eBook, No. 14725. http://www.gutenberg.org/files/14725/14725-h/14725-h.h (accessed 18 January 2005)'},{id:"B6",body:'Nelson E. Dynamical theories of Brownian motion. Princeton, New Jersey: Princeton Univ. Press; 2001.'},{id:"B7",body:'Nelson E. Quantum fluctuations. Princeton Series in Physics. Princeon, New Jersey: Princeton Univ. Press; 2001.'},{id:"B8",body:'Feynman RP., Hibbs A. Quantum mechanics and path integrals. N. Y.: McGraw Hill; 1965.'},{id:"B9",body:'Einstein A., von Smoluchowski M. Brownian motion. Moscow-Leningrad: ONTI (in Russian); 1936.'},{id:"B10",body:'Sidorov LN., Troyanov SI. At the dawn of a new chemistry of fullerenes. PRIRODA 2011; 1153(9) 22-30.'},{id:"B11",body:'Arndt M., Hackermüller L., Reiger E. Interferometry with large molecules: Exploration of coherence, decoherence and novel beam methods. Brazilian Journal of Physics 2005; 35(2A) 216-223.'},{id:"B12",body:'Brezger B., Arndt M., Zeilinger A. Concepts for near-field interferometers with large molecules. J. Opt. B: Quantum Semiclass. Opt. 2003; 5(2) S82-S89.'},{id:"B13",body:'Brezger B., Hackermüller L., Uttenthaler S., Petschinka J., Arndt M., Zeilinger A. Matter-Wave Interferometer for Large Molecules. Phys. Rev. Lett. 2002; 88 100404.'},{id:"B14",body:'Gerlich S., Eibenberger S., Tomandl M., Nimmrichter S., Hornberger K., Fagan P. J., Tuxen J., Mayor M., Arndt, M. Quantum interference of large organic molecules. Nature Communications 2011; (2) 263. http://www.nature.com/ncomms/journal/v2/n4/full/ncomms1263.html (accessed 5 April 2011)'},{id:"B15",body:'Hornberger K., Hackermüller L., Arndt M. Inuence of molecular temperature on the coherence of fullerenes in a near-field interferometer. Phys. Rev. A. 2005; 71, 023601.'},{id:"B16",body:'Hornberger K., Sipe JP., Arndt M. Theory of decoherence in a matter wave Talbot-Lau interferometer. Phys. Rev. A. 2004; 70, 053608.'},{id:"B17",body:'Nimmrichter S., Hornberger K. Theory of near-fieldmatter wave interference beyond the eikonal approximation. Phys. Rev. A. 2008; 78, 023612.'},{id:"B18",body:'Juffmann,T., Truppe S., Geyer P., Major AG., Deachapunya S., Ulbricht H., Arndt, M. Wave and particle in molecular interference lithography. Phys. Rev. Lett. 2009; 103, 263601.'},{id:"B19",body:'Berry M., Klein S. Integer, fractional and fractal Talbot effects, Journal of Modern Optics, 1996; 43(10) 2139-2164.'},{id:"B20",body:'Berry M., Marzoli L., Schleich W. Quantum carpets, carpets of light. Physics World, 2001; (6), 39-44.'},{id:"B21",body:'Couder Y., Fort E. Single-Particle Diffraction and Interference at a Macroscopic Scale. Phys. Rev. Lett. 2006; 97 (6), 154101(4).'},{id:"B22",body:'Stratonovich RL. Topics in the theory of random noise. N.Y.: Gordon and Breach; 1963.'},{id:"B23",body:'Gnedenko BV. Theory of Probability. N.Y.: Gordon & Breach; 1997.'},{id:"B24",body:'Ventzel AD. The course of stochastic processes theory. Moskow: Nauka (in Russian); 1975.'},{id:"B25",body:'Grosche C. An introduction into the Feynman path integral. http://arXiv.org/abs/hep-th/9302097 (accessed 20 February 1993).'},{id:"B26",body:'MacKenzie R. Path integral methods and applications. http://arXiv.org/abs/quant-ph/0004090 (accessed 20 April 2000).'},{id:"B27",body:'Juffmann T., Milic A., Müllneritsch M., Asenbaum P., Tsukernik A., Tüxen J., Mayor M., Cheshnovsky O., Arndt, M. Real-time single-molecule imaging of quantum interference. Nature Nanotechnology - Letter. 2012; 7, 297–300. http://www.nature.com/nnano/journal/v7/n5/full/nnano.2012.34.html?WT.ec_id=NNANO-201205 (accessed 25 March 2012)'},{id:"B28",body:'Sbitnev VI. Bohmian trajectories and the path integral paradigm - complexified Lagrangian mechanics. In: Pahlavani MR. (ed.) Theoretical Concepts of Quantum Mechanics. Rijeka: InTech; 2011 p313-340. http://www.intechopen.com/books/theoretical-concepts-of-quantum-mechanics/the-path-integral-paradigm-and-bohmian-trajectories-from-the-lagrangian-mechanics-to-complexified-on (accessed 2004-2012)'},{id:"B29",body:'Nairz O., Arndt M., Zeilinger A. Quantum interference experiments with large molecules. Am. J. Phys. 2003; 71 (4), 319-325. '},{id:"B30",body:'Sbitnev VI. Matter waves in the Talbot-Lau interferometry, http://arxiv.org/abs/1005.0890 (accessed 17 September 2010).'},{id:"B31",body:'Volokitin AI. Quantum drag and graphene. PRIRODA, 2011; 1153(9), 13-21.'},{id:"B32",body:'Mandel L., Wolf E. Optical coherence and quantum optics. Cambridge: Cambridge University Press; 1995.'},{id:"B33",body:'McMorran B.,Cronin AD. Model for partial coherence and wavefront curvature in grating interferometers. Phys. Rev. A. 2008; 78 (1), 013601(10).'},{id:"B34",body:'Gerlich S., Hackermüller L., Hornberger K., Stibor A., Ulbricht H., Gring M., Goldfarb F., Savas T., Müri M., Mayor M., Arndt, M. A Kapitza-Dirac-Talbot-Lau interferometer for highly polarizable molecules. Nature Physics. 2007; 3, 711-715.'},{id:"B35",body:'Bohm D. A suggested interpretation of the quantum theory in terms of "hidden variables", I & II. Physical Review, 1952; 85, 166-179 & 180-193.'},{id:"B36",body:'Madelung E. Quantentheorie in Hydrodynamischer form. Zts. f. Phys. 1926; 40, 322-326.'},{id:"B37",body:'Stanford Encyclopeia of Philosophy: Bohmian Mechanics. http://plato.stanford.edu/entries/qm-bohm/ (accessed 26 October 2001).'},{id:"B38",body:'Dirac PAM. The Lagrangian in Quantum Mechanics. Physikalische Zeitschrift der Sowjetunion. 1933; 3, 64-72.'},{id:"B39",body:'Dirac PAM. On the analogy between classical and quantum mechanics. Rev. Mod. Phys. 1945; 17 (2 & 3), 195-199.'}],footnotes:[{id:"fn1",explanation:" My attention to the Madelung' article was drawn by Prof. M. Berry."}],contributors:[{corresp:null,contributorFullName:"Valeriy I. Sbitnev",address:null,affiliation:'
St.-Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, Gatchina, Russia
'}],corrections:null},book:{id:"3513",type:"book",title:"Advances in Quantum Mechanics",subtitle:null,fullTitle:"Advances in Quantum Mechanics",slug:"advances-in-quantum-mechanics",publishedDate:"April 3rd 2013",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/3513.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-51-1089-7",pdfIsbn:"978-953-51-5036-7",reviewType:"peer-reviewed",numberOfWosCitations:62,isAvailableForWebshopOrdering:!0,editors:[{id:"92883",title:"Prof.",name:"Paul",middleName:null,surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1237"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"43824",type:"chapter",title:"Classical and Quantum Conjugate Dynamics – The Interplay Between Conjugate Variables",slug:"classical-and-quantum-conjugate-dynamics-the-interplay-between-conjugate-variables",totalDownloads:3788,totalCrossrefCites:0,signatures:"Gabino Torres-Vega",reviewType:"peer-reviewed",authors:[{id:"93519",title:"Dr.",name:"Gabino",middleName:null,surname:"Torres-Vega",fullName:"Gabino Torres-Vega",slug:"gabino-torres-vega"}]},{id:"43374",type:"chapter",title:"Classical and Quantum Correspondence in Anisotropic Kepler Problem",slug:"classical-and-quantum-correspondence-in-anisotropic-kepler-problem",totalDownloads:2745,totalCrossrefCites:1,signatures:"Keita Sumiya, Hisakazu Uchiyama, Kazuhiro Kubo and Tokuzo Shimada",reviewType:"peer-reviewed",authors:[{id:"97094",title:"Prof.",name:"Tokuzo",middleName:null,surname:"Shimada",fullName:"Tokuzo Shimada",slug:"tokuzo-shimada"}]},{id:"43818",type:"chapter",title:"Charathéodory’s “Royal Road” to the Calculus of Variations: A Possible Bridge Between Classical and Quantum Physics",slug:"charathe-odory-s-royal-road-to-the-calculus-of-variations-a-possible-bridge-between-classical-and-qu",totalDownloads:2516,totalCrossrefCites:0,signatures:"Francisco De Zela",reviewType:"peer-reviewed",authors:[{id:"101998",title:"Prof.",name:"Francisco",middleName:null,surname:"De Zela",fullName:"Francisco De Zela",slug:"francisco-de-zela"}]},{id:"43855",type:"chapter",title:"The Improvement of the Heisenberg Uncertainty Principle",slug:"the-improvement-of-the-heisenberg-uncertainty-principle",totalDownloads:4295,totalCrossrefCites:0,signatures:"L. M. Arévalo Aguilar, C. P. García Quijas and Carlos Robledo- Sanchez",reviewType:"peer-reviewed",authors:[{id:"102108",title:"Dr.",name:"L. M.",middleName:null,surname:"Arevalo Aguilar",fullName:"L. M. Arevalo Aguilar",slug:"l.-m.-arevalo-aguilar"},{id:"167844",title:"Dr.",name:"Carlos",middleName:null,surname:"Robledo Sanchez",fullName:"Carlos Robledo Sanchez",slug:"carlos-robledo-sanchez"},{id:"167845",title:"Dr.",name:"Paulo Cesar",middleName:null,surname:"Garcia Quijas",fullName:"Paulo Cesar Garcia Quijas",slug:"paulo-cesar-garcia-quijas"}]},{id:"43877",type:"chapter",title:"Schrödinger Equation as a Hamiltonian System, Essential Nonlinearity, Dynamical Scalar Product and some Ideas of Decoherence",slug:"schro-dinger-equation-as-a-hamiltonian-system-essential-nonlinearity-dynamical-scalar-product-and-so",totalDownloads:2684,totalCrossrefCites:0,signatures:"Jan J. Sławianowski and Vasyl Kovalchuk",reviewType:"peer-reviewed",authors:[{id:"103754",title:"Prof.",name:"Jan",middleName:"Jerzy",surname:"Slawianowski",fullName:"Jan Slawianowski",slug:"jan-slawianowski"},{id:"166959",title:"Ph.D.",name:"Vasyl",middleName:null,surname:"Kovalchuk",fullName:"Vasyl Kovalchuk",slug:"vasyl-kovalchuk"}]},{id:"43819",type:"chapter",title:"Schrödinger Equation and (Future) Quantum Physics",slug:"schro-dinger-equation-and-future-quantum-physics",totalDownloads:2609,totalCrossrefCites:1,signatures:"Miloš V. Lokajíček, Vojtěch Kundrát and Jiří Procházka",reviewType:"peer-reviewed",authors:[{id:"100173",title:"Dr.",name:"Miloš",middleName:"Vaclav",surname:"Lokajíček",fullName:"Miloš Lokajíček",slug:"milos-lokajicek"}]},{id:"43813",type:"chapter",title:"Quantum Damped Harmonic Oscillator",slug:"quantum-damped-harmonic-oscillator",totalDownloads:2768,totalCrossrefCites:2,signatures:"Kazuyuki Fujii",reviewType:"peer-reviewed",authors:[{id:"162635",title:"Dr.",name:null,middleName:null,surname:"Fujii",fullName:"Fujii",slug:"fujii"}]},{id:"43858",type:"chapter",title:"The Schwinger Action Principle and Its Applications to Quantum Mechanics",slug:"the-schwinger-action-principle-and-its-applications-to-quantum-mechanics",totalDownloads:3940,totalCrossrefCites:0,signatures:"Paul Bracken",reviewType:"peer-reviewed",authors:[{id:"92883",title:"Prof.",name:"Paul",middleName:null,surname:"Bracken",fullName:"Paul Bracken",slug:"paul-bracken"}]},{id:"43825",type:"chapter",title:"Generalized Path Integral Technique: Nanoparticles Incident on a Slit Grating, Matter Wave Interference",slug:"generalized-path-integral-technique-nanoparticles-incident-on-a-slit-grating-matter-wave-interferenc",totalDownloads:2538,totalCrossrefCites:4,signatures:"Valeriy I. Sbitnev",reviewType:"peer-reviewed",authors:[{id:"93881",title:"Dr.",name:"Valeriy",middleName:null,surname:"Sbitnev",fullName:"Valeriy Sbitnev",slug:"valeriy-sbitnev"}]},{id:"43912",type:"chapter",title:"Quantum Intentionality and Determination of Realities in the Space-Time Through Path Integrals and Their Integral Transforms",slug:"quantum-intentionality-and-determination-of-realities-in-the-space-time-through-path-integrals-and-t",totalDownloads:2502,totalCrossrefCites:3,signatures:"Francisco Bulnes",reviewType:"peer-reviewed",authors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",fullName:"Francisco Bulnes",slug:"francisco-bulnes"}]},{id:"43820",type:"chapter",title:"Convergence of the Neumann Series for the Schrödinger Equation and General Volterra Equations in Banach Spaces",slug:"convergence-of-the-neumann-series-for-the-schro-dinger-equation-and-general-volterra-equations-in-ba",totalDownloads:4240,totalCrossrefCites:0,signatures:"Fernando D. Mera and Stephen A. Fulling",reviewType:"peer-reviewed",authors:[{id:"162522",title:"Prof.",name:"Stephen",middleName:null,surname:"Fulling",fullName:"Stephen Fulling",slug:"stephen-fulling"},{id:"162523",title:"Mr.",name:"Fernando",middleName:null,surname:"Mera",fullName:"Fernando Mera",slug:"fernando-mera"}]},{id:"43864",type:"chapter",title:"Quantum Perturbation Theory in Fluid Mixtures",slug:"quantum-perturbation-theory-in-fluid-mixtures",totalDownloads:2306,totalCrossrefCites:0,signatures:"S. M. Motevalli and M. Azimi",reviewType:"peer-reviewed",authors:[{id:"115345",title:"Dr.",name:"Seyed Mohammad",middleName:null,surname:"Motevalli",fullName:"Seyed Mohammad Motevalli",slug:"seyed-mohammad-motevalli"}]},{id:"43830",type:"chapter",title:"Quantal Cumulant Mechanics as Extended Ehrenfest Theorem",slug:"quantal-cumulant-mechanics-as-extended-ehrenfest-theorem",totalDownloads:2684,totalCrossrefCites:0,signatures:"Yasuteru Shigeta",reviewType:"peer-reviewed",authors:[{id:"104142",title:"Dr.",name:"Yasuteru",middleName:null,surname:"Shigeta",fullName:"Yasuteru Shigeta",slug:"yasuteru-shigeta"}]},{id:"43922",type:"chapter",title:"Unruh Radiation via WKB Method",slug:"unruh-radiation-via-wkb-method",totalDownloads:3236,totalCrossrefCites:0,signatures:"Douglas A. Singleton",reviewType:"peer-reviewed",authors:[{id:"163082",title:"Prof.",name:"Douglas",middleName:null,surname:"Singleton",fullName:"Douglas Singleton",slug:"douglas-singleton"}]},{id:"43860",type:"chapter",title:"A Basis for Statistical Theory and Quantum Theory",slug:"a-basis-for-statistical-theory-and-quantum-theory",totalDownloads:2418,totalCrossrefCites:0,signatures:"Inge S. Helland",reviewType:"peer-reviewed",authors:[{id:"161967",title:"Prof.",name:"Inge S.",middleName:null,surname:"Helland",fullName:"Inge S. Helland",slug:"inge-s.-helland"}]},{id:"43861",type:"chapter",title:"Relational Quantum Mechanics",slug:"relational-quantum-mechanics",totalDownloads:2294,totalCrossrefCites:0,signatures:"A. Nicolaidis",reviewType:"peer-reviewed",authors:[{id:"162692",title:"Associate Prof.",name:"Argyris",middleName:null,surname:"Nicolaidis",fullName:"Argyris Nicolaidis",slug:"argyris-nicolaidis"}]},{id:"43913",type:"chapter",title:"On the Dual Concepts of 'Quantum State' and 'Quantum Process'",slug:"on-the-dual-concepts-of-quantum-state-and-quantum-process-",totalDownloads:2222,totalCrossrefCites:0,signatures:"Cynthia Kolb Whitney",reviewType:"peer-reviewed",authors:[{id:"103463",title:"Dr.",name:"Cynthia",middleName:null,surname:"Whitney",fullName:"Cynthia Whitney",slug:"cynthia-whitney"}]},{id:"43949",type:"chapter",title:"The Computational Unified Field Theory (CUFT): A Candidate 'Theory of Everything'",slug:"the-computational-unified-field-theory-cuft-a-candidate-theory-of-everything-",totalDownloads:2097,totalCrossrefCites:0,signatures:"Jonathan Bentwich",reviewType:"peer-reviewed",authors:[{id:"99692",title:"Dr.",name:"Jonathan",middleName:null,surname:"Bentwich",fullName:"Jonathan Bentwich",slug:"jonathan-bentwich"}]},{id:"43769",type:"chapter",title:"Emergent un-Quantum Mechanics",slug:"emergent-un-quantum-mechanics",totalDownloads:3226,totalCrossrefCites:0,signatures:"John P. Ralston",reviewType:"peer-reviewed",authors:[{id:"163582",title:"Prof.",name:"John",middleName:null,surname:"Ralston",fullName:"John Ralston",slug:"john-ralston"}]},{id:"43760",type:"chapter",title:"The Wigner-Heisenberg Algebra in Quantum Mechanics",slug:"the-wigner-heisenberg-algebra-in-quantum-mechanics",totalDownloads:4272,totalCrossrefCites:0,signatures:"Rafael de Lima Rodrigues",reviewType:"peer-reviewed",authors:[{id:"162697",title:"Dr.",name:"Rafael",middleName:"De Lima",surname:"Rodrigues",fullName:"Rafael Rodrigues",slug:"rafael-rodrigues"}]},{id:"43815",type:"chapter",title:"New System-Specific Coherent States by Supersymmetric Quantum Mechanics for Bound State Calculations",slug:"new-system-specific-coherent-states-by-supersymmetric-quantum-mechanics-for-bound-state-calculations",totalDownloads:2951,totalCrossrefCites:0,signatures:"Chia-Chun Chou, Mason T. Biamonte, Bernhard G. Bodmann and Donald J. Kouri",reviewType:"peer-reviewed",authors:[{id:"102016",title:"Dr.",name:"Donald",middleName:"Jack",surname:"Kouri",fullName:"Donald Kouri",slug:"donald-kouri"}]},{id:"43761",type:"chapter",title:"Quantum Dating Market",slug:"quantum-dating-market",totalDownloads:1988,totalCrossrefCites:0,signatures:"C. M. Arizmendi and O. G. Zabaleta",reviewType:"peer-reviewed",authors:[{id:"162718",title:"Dr.",name:"Constancio Miguel",middleName:null,surname:"Arizmendi",fullName:"Constancio Miguel Arizmendi",slug:"constancio-miguel-arizmendi"},{id:"162728",title:"Dr.",name:"Omar Gustavo",middleName:null,surname:"Zabaleta",fullName:"Omar Gustavo Zabaleta",slug:"omar-gustavo-zabaleta"}]},{id:"41542",type:"chapter",title:"Quantization as Selection Rather than Eigenvalue Problem",slug:"quantization-as-selection-rather-than-eigenvalue-problem",totalDownloads:2106,totalCrossrefCites:1,signatures:"Peter Enders",reviewType:"peer-reviewed",authors:[{id:"162719",title:"Prof.",name:"Peter",middleName:null,surname:"Enders",fullName:"Peter Enders",slug:"peter-enders"}]},{id:"43862",type:"chapter",title:"Entanglement, Nonlocality, Superluminal Signaling and Cloning",slug:"entanglement-nonlocality-superluminal-signaling-and-cloning",totalDownloads:2644,totalCrossrefCites:1,signatures:"GianCarlo Ghirardi",reviewType:"peer-reviewed",authors:[{id:"162757",title:"Emeritus Prof.",name:"GianCarlo",middleName:null,surname:"Ghirardi",fullName:"GianCarlo Ghirardi",slug:"giancarlo-ghirardi"}]},{id:"43945",type:"chapter",title:"The Husimi Distribution: Development and Applications",slug:"the-husimi-distribution-development-and-applications",totalDownloads:3564,totalCrossrefCites:0,signatures:"Sergio Curilef and Flavia Pennini",reviewType:"peer-reviewed",authors:[{id:"125424",title:"Prof.",name:"Sergio",middleName:null,surname:"Curilef",fullName:"Sergio Curilef",slug:"sergio-curilef"},{id:"167175",title:"Dr.",name:"Flavia",middleName:null,surname:"Pennini",fullName:"Flavia Pennini",slug:"flavia-pennini"}]},{id:"43865",type:"chapter",title:"The Quantum Mechanics Aspect of Structural Transformations in Nanosystems",slug:"the-quantum-mechanics-aspect-of-structural-transformations-in-nanosystems",totalDownloads:2060,totalCrossrefCites:0,signatures:"M. D. Bal’makov",reviewType:"peer-reviewed",authors:[{id:"163642",title:"Dr",name:null,middleName:null,surname:"Balmakov",fullName:"Balmakov",slug:"balmakov"}]},{id:"43857",type:"chapter",title:"Decoding the Building Blocks of Life from the Perspective of Quantum Information",slug:"decoding-the-building-blocks-of-life-from-the-perspective-of-quantum-information",totalDownloads:3027,totalCrossrefCites:1,signatures:"Rodolfo O. Esquivel, Moyocoyani Molina-Espíritu, Frank Salas, Catalina Soriano, Carolina Barrientos, Jesús S. Dehesa and José A. Dobado",reviewType:"peer-reviewed",authors:[{id:"98696",title:"Dr.",name:"Rodolfo",middleName:null,surname:"Esquivel",fullName:"Rodolfo Esquivel",slug:"rodolfo-esquivel"}]},{id:"42514",type:"chapter",title:"The Theoretical Ramifications of the Computational Unified Field Theory",slug:"the-theoretical-ramifications-of-the-computational-unified-field-theory",totalDownloads:2130,totalCrossrefCites:0,signatures:"Jonathan Bentwich",reviewType:"peer-reviewed",authors:[{id:"99692",title:"Dr.",name:"Jonathan",middleName:null,surname:"Bentwich",fullName:"Jonathan Bentwich",slug:"jonathan-bentwich"}]},{id:"41649",type:"chapter",title:"Shannon Informational Entropies and Chemical Reactivity",slug:"shannon-informational-entropies-and-chemical-reactivity",totalDownloads:2085,totalCrossrefCites:0,signatures:"Nelson Flores-Gallegos",reviewType:"peer-reviewed",authors:[{id:"93621",title:"Dr.",name:"Nelson",middleName:null,surname:"Flores-Gallegos",fullName:"Nelson Flores-Gallegos",slug:"nelson-flores-gallegos"}]},{id:"43856",type:"chapter",title:"A Novel Isospectral Deformation Chain in Supersymmetric Quantum Mechanics",slug:"a-novel-isospectral-deformation-chain-in-supersymmetric-quantum-mechanics",totalDownloads:2119,totalCrossrefCites:0,signatures:"Bjorn Jensen",reviewType:"peer-reviewed",authors:[{id:"96491",title:"Dr.",name:"Bjorn",middleName:null,surname:"Jensen",fullName:"Bjorn Jensen",slug:"bjorn-jensen"}]},{id:"43879",type:"chapter",title:"Quantum Effects Through a Fractal Theory of Motion",slug:"quantum-effects-through-a-fractal-theory-of-motion",totalDownloads:2190,totalCrossrefCites:0,signatures:"M. Agop, C.Gh. Buzea, S. Bacaita, A. Stroe and M. Popa",reviewType:"peer-reviewed",authors:[{id:"24020",title:"Dr.",name:"Maricel",middleName:null,surname:"Agop",fullName:"Maricel Agop",slug:"maricel-agop"}]}]},relatedBooks:[{type:"book",id:"5488",title:"Manifolds",subtitle:"Current Research Areas",isOpenForSubmission:!1,hash:"e1193790ca2c8027d4ffc6911dd24365",slug:"manifolds-current-research-areas",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/5488.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"53492",title:"Mutiple Hopf Bifurcation on Center Manifold",slug:"mutiple-hopf-bifurcation-on-center-manifold",signatures:"Qinlong Wang, Bo Sang and Wentao Huang",authors:[{id:"191996",title:"Dr.",name:"Qinlong",middleName:null,surname:"Wang",fullName:"Qinlong Wang",slug:"qinlong-wang"},{id:"195099",title:"Dr.",name:"Bo",middleName:null,surname:"Sang",fullName:"Bo Sang",slug:"bo-sang"},{id:"195100",title:"Prof.",name:"Wentao",middleName:null,surname:"Huang",fullName:"Wentao Huang",slug:"wentao-huang"}]},{id:"53713",title:"An Intrinsic Characterization of Bonnet Surfaces Based on a Closed Differential Ideal",slug:"an-intrinsic-characterization-of-bonnet-surfaces-based-on-a-closed-differential-ideal",signatures:"Paul Bracken",authors:[{id:"92883",title:"Prof.",name:"Paul",middleName:null,surname:"Bracken",fullName:"Paul Bracken",slug:"paul-bracken"}]},{id:"53552",title:"Sub-Manifolds of a Riemannian Manifold",slug:"sub-manifolds-of-a-riemannian-manifold",signatures:"Mehmet Atçeken, Ümit Yıldırım and Süleyman Dirik",authors:[{id:"191326",title:"Prof.",name:"Mehmet",middleName:null,surname:"Atceken",fullName:"Mehmet Atceken",slug:"mehmet-atceken"},{id:"196148",title:"Dr.",name:"Umit",middleName:null,surname:"Yildirim",fullName:"Umit Yildirim",slug:"umit-yildirim"}]},{id:"53712",title:"Spectral Theory of Operators on Manifolds",slug:"spectral-theory-of-operators-on-manifolds",signatures:"Paul Bracken",authors:[{id:"92883",title:"Prof.",name:"Paul",middleName:null,surname:"Bracken",fullName:"Paul Bracken",slug:"paul-bracken"}]},{id:"52596",title:"Symplectic Manifolds: Gromov-Witten Invariants on Symplectic and Almost Contact Metric Manifolds",slug:"symplectic-manifolds-gromov-witten-invariants-on-symplectic-and-almost-contact-metric-manifolds",signatures:"Yong Seung Cho",authors:[{id:"62522",title:"Prof.",name:"Yong Seung",middleName:null,surname:"Cho",fullName:"Yong Seung Cho",slug:"yong-seung-cho"}]},{id:"52886",title:"Head Pose Estimation via Manifold Learning",slug:"head-pose-estimation-via-manifold-learning",signatures:"Chao Wang, Yuanhao Guo and Xubo Song",authors:[{id:"190308",title:"Dr.",name:"Chao",middleName:null,surname:"Wang",fullName:"Chao Wang",slug:"chao-wang"},{id:"190461",title:"Prof.",name:"Xubo",middleName:null,surname:"Song",fullName:"Xubo Song",slug:"xubo-song"},{id:"191562",title:"MSc.",name:"Yuanhao",middleName:null,surname:"Guo",fullName:"Yuanhao Guo",slug:"yuanhao-guo"}]},{id:"53109",title:"A Fusion Scheme of Local Manifold Learning Methods",slug:"a-fusion-scheme-of-local-manifold-learning-methods",signatures:"Xianglei Xing, Kejun Wang and Weixing Feng",authors:[{id:"30150",title:"Prof.",name:"Kejun",middleName:null,surname:"Wang",fullName:"Kejun Wang",slug:"kejun-wang"},{id:"191016",title:"Dr.",name:"Xianglei",middleName:null,surname:"Xing",fullName:"Xianglei Xing",slug:"xianglei-xing"},{id:"196253",title:"Prof.",name:"Weixing",middleName:null,surname:"Feng",fullName:"Weixing Feng",slug:"weixing-feng"}]}]}],publishedBooks:[{type:"book",id:"3513",title:"Advances in Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"bbea1c081216f267a4480707f4ead9cf",slug:"advances-in-quantum-mechanics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/3513.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4503",title:"Selected Topics in Applications of Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"49ea5b364e379eac3ca7747bc170c217",slug:"selected-topics-in-applications-of-quantum-mechanics",bookSignature:"Mohammad Reza Pahlavani",coverURL:"https://cdn.intechopen.com/books/images_new/4503.jpg",editedByType:"Edited by",editors:[{id:"101263",title:"Prof.",name:"Mohammad Reza",surname:"Pahlavani",slug:"mohammad-reza-pahlavani",fullName:"Mohammad Reza Pahlavani"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7788",title:"Progress in Relativity",subtitle:null,isOpenForSubmission:!1,hash:"258de121f66ce548dbf7a88bc569b58e",slug:"progress-in-relativity",bookSignature:"Calin Gheorghe Buzea, Maricel Agop and Leo Butler",coverURL:"https://cdn.intechopen.com/books/images_new/7788.jpg",editedByType:"Edited by",editors:[{id:"99400",title:"Dr.",name:"Calin Gheorghe",surname:"Buzea",slug:"calin-gheorghe-buzea",fullName:"Calin Gheorghe Buzea"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10205",title:"Quantum Chromodynamic",subtitle:null,isOpenForSubmission:!1,hash:"0d9403b5c874f6e63b0686cd7c432e00",slug:"quantum-chromodynamic",bookSignature:"Zbigniew Piotr Szadkowski",coverURL:"https://cdn.intechopen.com/books/images_new/10205.jpg",editedByType:"Edited by",editors:[{id:"67836",title:"Prof.",name:"Zbigniew Piotr",surname:"Szadkowski",slug:"zbigniew-piotr-szadkowski",fullName:"Zbigniew Piotr Szadkowski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1613",title:"Theoretical Concepts of Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"f9c6e9ac171d39eecb718608fb626430",slug:"theoretical-concepts-of-quantum-mechanics",bookSignature:"Mohammad Reza Pahlavani",coverURL:"https://cdn.intechopen.com/books/images_new/1613.jpg",editedByType:"Edited by",editors:[{id:"101263",title:"Prof.",name:"Mohammad Reza",surname:"Pahlavani",slug:"mohammad-reza-pahlavani",fullName:"Mohammad Reza Pahlavani"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"1613",title:"Theoretical Concepts of Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"f9c6e9ac171d39eecb718608fb626430",slug:"theoretical-concepts-of-quantum-mechanics",bookSignature:"Mohammad Reza Pahlavani",coverURL:"https://cdn.intechopen.com/books/images_new/1613.jpg",editedByType:"Edited by",editors:[{id:"101263",title:"Prof.",name:"Mohammad Reza",surname:"Pahlavani",slug:"mohammad-reza-pahlavani",fullName:"Mohammad Reza Pahlavani"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3513",title:"Advances in Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"bbea1c081216f267a4480707f4ead9cf",slug:"advances-in-quantum-mechanics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/3513.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4503",title:"Selected Topics in Applications of Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"49ea5b364e379eac3ca7747bc170c217",slug:"selected-topics-in-applications-of-quantum-mechanics",bookSignature:"Mohammad Reza Pahlavani",coverURL:"https://cdn.intechopen.com/books/images_new/4503.jpg",editedByType:"Edited by",editors:[{id:"101263",title:"Prof.",name:"Mohammad Reza",surname:"Pahlavani",slug:"mohammad-reza-pahlavani",fullName:"Mohammad Reza Pahlavani"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5918",title:"Trends in Modern Cosmology",subtitle:null,isOpenForSubmission:!1,hash:"6fbfd7e2f33ac06d54517d3b52005231",slug:"trends-in-modern-cosmology",bookSignature:"Abraao Jesse Capistrano de Souza",coverURL:"https://cdn.intechopen.com/books/images_new/5918.jpg",editedByType:"Edited by",editors:[{id:"52362",title:"Dr.",name:"Abraao",surname:"Capistrano",slug:"abraao-capistrano",fullName:"Abraao Capistrano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"68465",title:"Ocimum Phytochemicals and Their Potential Impact on Human Health",doi:"10.5772/intechopen.88555",slug:"-em-ocimum-em-phytochemicals-and-their-potential-impact-on-human-health",body:'
1. Introduction
Living plants produce a vast quantity of chemicals required for their performance and improvement. Some of these chemicals are primary metabolites, which consist of proteins (amino acids), carbohydrates, fats, nucleic acids, etc. but, besides these primary chemicals, the plants further provide just so-called secondary metabolites, which are specific to some taxonomic groups (families, genera). About 80% of the world’s population still depends on the traditional system of medicine for curing several health hazards [1]. Despite the vast scientific development in contemporary medicine, Ayurvedic system of medicine is widely practiced and accepted by people not only in India but also in many developed countries. According to the World Health Organization (WHO), about 80% of patients in India still, rely on the practitioners of the traditional system of medicines. The therapeutic use of herbal crude medicines in different rural and urban communities is most of the time regulated by their traditional beliefs, and thus a majority of the herbal drugs are used as “folk” medicines and well practiced since long past. Furthermore, increasing dependency on medicinal plants in the industrialized communities have been found to the extraction and improvement of several remedies and chemotherapeutics from these plants and from traditionally established rural herbal remedies [2]. In these communities, herbal remedies become deeply engaged in the practice of minor conditions and again on the explanation of the increasing costs of specific health maintenance. Although synthetic drugs enhanced the demand against green remedies because of their rapid-acting implements, people have been turned up to understand the benefits correlated with essential remedies. Chemically prepared drugs may act at earlier, but they side effects which influence the human body separately in the long run, because medicinal plants work in an integrated or probiotic with limited or no negative effects on the body [3].
The genus Ocimum includes approximately 150 species, possessing a great variation in plant morphology and biology, essential oil content, and chemical composition [4]. The economic importance and global dissemination of Ocimum, with its many uses in cooking and folk medicine, make it important to investigate its pharmacological and toxicological effects in order to ensure its efficacy and safety. In India, among the medicinal herbs known for their healing properties, the genus Ocimum (commonly known as ‘Basil’ or ‘Tulsi’) is very important for its curative potential. Basils contain a wide range of essential oils rich in phenolic compounds and a wide array of other natural products including flavonoids and anthocyanins [5] having great pharmacological importance.
Nowadays, scientists are mainly focused on exploring the potential of plant antioxidants for curing several diseases. Antioxidants are compounds that can delay or inhibit the oxidation of lipids or other molecules by inhibiting the initiation or propagation of oxidative chain reactions [6]. Antioxidants counteract the harmful reactive oxygen species (ROS) and free radicals generated in the living organism during regular metabolism, especially under stress conditions. Several in vitro and in vivo studies have already proved the antioxidative property of beta-carotene, alfa-tocopherol, ascorbic acids, phenolics, flavonoids present in different plants [7].
Presently due to our regular stressful lifestyle, we are suffering from several types of diseases like aging, diabetes, degenerative disorders, etc., which mainly develop due to the development of ROS in our body. A dynamic balance is already operating in our body to reduce the harmful effects of generated ROS that is not adequate enough. Therefore, it is obvious to enrich our diet with antioxidants for developing protection. The purpose of this paper will focus on the recent research of the major nutrients and phytochemicals of Ocimum and their potential health benefits related to the dietary prevention of chronic diseases.
2. Health benefits of phytochemicals
“Phyto” in the word of phytochemicals is derived from the Greek word “phyto,” which means plant. Phytochemicals are a naturally occurring group of chemicals in plants and plant-derived foods, which may function in reducing the risk of chronic diseases [8]. Although it is estimated at least more than 5000 dietary phytochemicals have been discovered, it is believed that a high percentage of phytochemicals in foods still remain unknown [8]. Critical reviews of studies available in the literature support the concept that phytochemicals (polyphenols, tocopherols, tocotrienols, carotenoids, and ascorbic acid) has been associated with the maintenance of good health as well as prevention/treatment of many health conditions including cancer, cardiovascular diseases, diabetes, hypertension, stroke, metabolic syndrome, and other degenerative diseases. It is largely accepted that the additive effects of the combinations of various phytochemicals in whole plant-based foods are shown to have stronger protective actions than single, isolated phytochemical compounds [9].
3. Role of secondary metabolites
New drug model seeks to meet on bringing compounds active toward target proteins. Even though newly pharmaceutical companies and support organizations take influence in molecular design, combinatorial chemistry and synthetic chemistry, natural productions, and especially those of plant source, remain as a prerequisite cause of new remedies, current medicine leads and other new synthetic entities (NCEs) [10, 11].
Plants produce a diverse array of compounds that can broadly be categorized into primary and secondary metabolites. Primary metabolites are the ones which are required for the normal growth and biological processes and are produced in the pathways that are crucial for plant survival. The other class of metabolites, though generally termed secondary, is also very crucial for plants from the ecological perspective.
These secondary metabolites are classified on the basis of their biosynthetic pathway and the following types are frequently observed-terpenes, phenylpropanoids, alkaloids, saponins, and glucosinolates. The availability of carbon, nitrogen, and sulfur along with energy from the primary metabolism governs the biosynthesis of these compounds [12].
4. Classification of secondary metabolites
Metabolites are the mediators and amounts of metabolism. The term metabolite is commonly confined to narrow fragments. Metabolites have specific functions, consisting of fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, and the catalytic activity of their holding (mostly as a cofactor to a stimulant), defense and interaction with distinct pathogens. Plant metabolites are categorized based on their biosynthetic pathways. The pathways of biosynthesis are responsible for the occurrence of both primary and secondary metabolites (Figure 1) [13, 14]. Plant secondary metabolites can be classified on the basis of chemical structure (for example, having rings, containing a sugar), composition (consisting of nitrogen or not), their solubility in numerous solvents, or the pathway by which they are synthesized (e.g., phenylpropanoid, which provides tannins).
Figure 1.
Major pathways of biosynthesis of secondary metabolites [15].
5. Essential oil of Ocimum species
Since ancient times, essential oils are known for their medicinal use, and they are very much interesting and impressive natural plant commodities. They continue to be of paramount importance until the present day. Essential oils have been tested as perfumes, flavors for foods and beverages, or to provide both bodies and care for thousands of years [16].
Chemical diversification is of special significance if at the genus or species level both terpenes and phenylpropenes can be formed in the essential oil. Most Lamiaceae preferentially accumulate mono-(and sesqui-)terpenes in their erratic oils but some genera show oils too rich in phenylpropenes [17].
The action of essential oils begins by entering the human body via three possible different ways including direct absorption through inhalation, ingestion or diffusion through the skin tissue.
Table 1 presents published compositions of species-wise distribution of bioactive compounds in Ocimum species.
Compositions of species-wise distribution of bioactive compounds in Ocimum species.
6. Biological activities of Ocimum species
The genus Ocimum (family Lamiaceae), collectively known as basil, is composed of a diverse and rich source of essential oil containing plants. The main issues of concern with the use of herbal drugs remain safety, validation of claims and standardization of product. Different species and forms of Ocimum spp. vary in growth habit, color, and aromatic composition, making the true botanical identity of basil difficult (Figure 2). There exist the problems of significant variation in the content of Ocimum plants across and within species, with the implication of varied biological activities. During the last two decades, it has been shown that Ocimum oil and its constituents possess different biological activities including antioxidant, antimicrobial, anticancer, and anti-inflammatory properties.
Figure 2.
Different species of Ocimum (a) Ocimum basilicum L.; (b) Ocimum kilimandscharicum Guerke; (c) Ocimum gratissimum L.; (d) Ocimum canum Sims.; (e) Ocimum tenuiflorum L. syn. O. sanctum L. (purple type); (f) Ocimum tenuiflorum (white type).
6.1 Oxidant activity
Anti-oxidants play an important function in protecting the body against free radicals. They achieve this by stopping the formation of new free radicals species, converting older ones to free radicals, less toxic molecules that can be easily mopped up and preventing radical chain reaction [62]. The principal function of anti-oxidants is in suspending the oxidation of other molecules, by inhibiting the initiation or propagation of oxidizing chain reactions by free radicals and thereby reducing oxidative damage to the human body [63]. Two great mechanisms of procedure have been proposed for antioxidants [64]. The initial is a chain breaking method by which the initial antioxidant provides an electron to the free radical stage in the systems. The second technique involves the destruction of ROS/reactive nitrogen species initiators (secondary antioxidants) by cutting off chain starting catalysts (Figure 2). The potential role in the food industry and human health, antioxidants are getting acceptance all across the globe. Antioxidants are defined as a substance that easily in small amounts, can inhibit or prohibit the oxidation of readily oxidizable elements. The antioxidant is also defined as a substance qualified of inhibiting special oxidizing stimulants or a substance that serves with oxidizing agents prior to creating damage to other fragments or a substance that sequesters metal ions or even a substance efficient of the recovering system such as iron transporting protein [65].
Natural antioxidants have been studied intensively during the past years which are mainly phenolic compounds. Moreover, oxidation is a degenerative process in biological systems due to the endogenous reactive oxygen species (ROS). Reactive oxygen species (ROS) are chemical properties originate in the body during metabolism that is overmuch reactive and may have one or expanded unpaired electrons. Oxidative stress, i.e., an inequality between ROS and antioxidant defenses have deleterious aftereffect, such as the peroxidation of membrane lipids and the aggression on biomolecules (proteins, membrane enzymes, carbohydrates and DNA) [66].
Various Ocimum species and their extracts or essential oils have been determined to achieve antioxidant activity [67, 68]. Phenolic acids, hydroxycinnamates, and flavonoids are perhaps the major antioxidants [67]. Vitamin antioxidants (e.g., ascorbic acid and carotenoids) are secondary contributors to the overall antioxidant capacity [69]. In essential oils, unsaturated terpenes having a cyclohexadiene structure (e.g., terpinene) and secondary cyclic oxygenated terpenes (e.g., thymol) may lead to antioxidant capacity, while acyclic unsaturated oxygenated monoterpenes (e.g., linalool), aromatic oxygenated monoterpenes (e.g., eugenol), methylchavicol (estragole), sesquiterpene hydrocarbons (e.g., α-bergamotene, germacrene D, γ-cadinene, δ-cadinene, β-selinene, sesquiterpenes oxygenated (e.g., spathulenol) may act as pro-oxidants [68].
Different test methods have been applied, and it becomes to be understood between the complete essential oil and individual components [70, 71, 72, 73]. A strong chelating effect on metals as iron or copper has been reported to diminish the presence of ROS obtained from reactions bar with these metals [74]. In addition, the antioxidant actions of Ocimum essential oils have also been found employing metal-independent oxidative processes [75] or controlling stable free radicals, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical [71, 76]. The DPPH test, a test widely used to measure the ability to donate hydrogen atoms [77], was applied to measure the antioxidant capacities of Ocimum species extracted by different solvent systems; these include the methanol extracts of O. basilicum L., O. canum Sims., O. gratissimum L., O. kilimandscharicum Guerke, O. sanctum, O. tenuiflorum [67, 71, 76, 78, 79, 80]; the ethanol extracts from O. basilicum L., O. gratissimum L., O. kilimandscharicum Guerke, O. sanctum [76, 79, 81, 82, 83].
Particular attention has been focused on the scavenger ability to inhibit the process of low-density lipoprotein (LDL) cholesterol oxidation since it represents a major prevention mechanism against atherosclerosis. Various experimental evidence, using in vitro and in vivo preclinical models, showed a strong action of Ocimum essential oils [84]. Moreover, Aqueous extracts Ocimum sanctum and 70% ethanol extracts Ocimum basilicum L. were able to reduce 5-lipoxygenase-driven cellular recruitment of leukocytes and the damaging consequences of their ability to release ROS while leaving unimpaired the generation of prostaglandins, which promote microvascular blood flow and act as immunomodulators [85, 86, 87].
In many cases, the antioxidative activity (Figure 3) of essential oils cannot be attributed to the main compounds; minor compounds and synergistic effect may significantly contribute to the activity.
Figure 3.
Types of antioxidants.
6.2 Antimicrobial
For thousands of years, folk medicine has used Ocimum leaf for the treatment of infections. Such protective properties have been confirmed by several studies performed in the last decades using Ocimum essential oil [29] or isolated compounds. Gram-positive and Gram-negative bacteria, as well as antiprotozoal and also anti-Trichomonas vaginalis, resulted sensitive to the antiproliferative action of Ocimum oil and its derivatives [29, 88, 89, 90]. At present, the exact mechanism responsible for the antimicrobial activity of Ocimum oil and its derivatives is still not completely clarified, although various modes of action in the bacterial cell have been discussed including degradation of the cell wall, damage to cytoplasmic membrane and membrane proteins, leakage of cell contents, coagulation of cytoplasm, and depletion of proton motive force [91, 92, 93].
The antibacterial and antifungal activities of Ocimum species have been studied on various bacteria and fungi [29, 94, 95, 96]. These studies indicate that essential oils are more efficient antifungals and antibacterials compared to the polar extracts [97, 98, 99]. Ocimum sanctum essential oils showed remarkable antimicrobial activity against bacteria and other microorganisms, such as periodontopathogens [100], mainly due to the presence of oxygenated monoterpenes in their chemical compositions [101].
The essential oil and methanol extracts of five Ocimum species have an appreciable activity against seven human pathogenic bacteria [29], essential oils of Ocimum species showed strong antimicrobial activity against all seven microorganisms tested. Oils of seven Ocimum taxa (O. americanum L., O. basilicum L., O. campechianum Mill., O. x citriodorum Vis., O. kilimandscharicum Baker ex Gürke and three botanical varieties and cultivars of Ocimum basilicum L.: ‘Genovese’, var. difforme and var. purpurascens)) showed strong antimicrobial activity against all 8 microorganisms tested by Carovic-Stanko et al. [102].
Among the antifungal activities, the in vitro antifungal activity of O. basilicum L. essential oil against Aspergillus flavus fungal growth and aflatoxin B1 production [103], essential oils of O. basilicum L. showed strong antifungal activity against A. flavus, and the main components were linalool, 1,8-cineol, eugenol, methyl cinnamate, α-cubebene, caryophyllene, β-ocimene and α-farnesene.
6.3 Anticancer activity
For a long time, the polyphenols of the Ocimum oil of the diet have been considered to play a role for the prevention of certain types of cancer in the Asian origin [104]. Even more than in Ocimum oil, constituents present in Ocimum leaf extract has shown strong antioxidant potency and inhibition of cancer cell proliferation, thus suggesting the protection against the genotoxic action of the ROS as one of the mechanisms explaining the anticancer effects of these compounds. Indeed, either methanol aqueous Ocimum basilicum L. leaf extract or the isolated constituents eugenol epoxide free radical scavenging activity and growth inhibition at low micromolar concentration on human breast cancer cell lines (MCF-7 and MDA-MB-231) [105, 106] and Human cancerous cell lines (HL60-promyelocytic blood leukemia cells) [107]. Such findings were further confirmed by other in vitro reports, testing the effects of Ocimum basilicum L. against four different humans cancer cell lines viz. human cervix adenocarcinoma HeLa cells, human melanoma FemX cells, human chronic myelogenous leukemia K562 cells, and human ovarian SKOV3 cells [108]. Furthermore, Karthikeyan et al. [109] demonstrated regression of tumors caused by orally administrated aqueous and ethanolic extracts of Ocimum sanctum in mice that developed spontaneous soft tissue sarcomas.
Monga et al. [110] studied the antimelanoma and radioprotective activity of essential oils obtained by 50% alcoholic aqueous leaf extract from five species of Ocimum viz. Ocimum sanctum (SE), Ocimum gratissimum, Ocimum basilicum, Ocimum canum, and Ocimum kilimandscharicum, were evaluated using C57BL and Swiss albino mice tumorigenesis; growth inhibition has in fact been associated with (a) reduction of tumor volume (b) blockage of messengers of pathways involved in cell proliferation was evident in all the oils but the greater was shown by that obtained from Ocimum tenuiflorum (syn. O. sanctum) compared to other Ocimum species. In various experiments and test systems, some mono-and sesquiterpenes showed activity, where camphor, 1,8-cineole and limonene were of greatest interest. Camphor, 1,8-cineole and limonene, the anti-inflammatory compound of Ocimum kilimandscharicum oil, showed a strong time-and dose-dependent cytotoxic effect on human ovarian cancer cell [111]. The potential antitumor effects of camphor have been shown previously [112, 113], and the mechanistic action of camphor against cancer included the improvement of immune function [114] and the radiosensitizing effect on transplantable mammary adenocarcinoma in mice [112]. Ursolic acid showed some potentiating effect on the anticancer activity of rosmarinic acid, cinnamic acid, caffeic acid, sinapic acid, and ferulic acid on various cell lines [106].
6.4 Cardiovascular protection
For decades, investigation on the health-promoting effects of Asian diet has been revealed that Ocimum oil consumption is a key factor in the cardiovascular protection found in Asian origin [115]. It is well established that the healthful properties of Ocimum basilicum L. oil depend largely on its Cardiac glycosides and catecholamines content [116]. But, many arguments prove that in Ocimum oil there are little bioactive components, much than Cardiac glycosides and catecholamines, effective for its cardiovascular protective properties: among them, the ethanolic fraction of Ocimum oil, and in specific omega-3 fatty acids have proved antioxidant, anti-platelet aggregation, vasodilatory, and anti-inflammatory effects, all engaged in this health beneficial action [117, 118, 119].
Oxidation of LDL cholesterol is one of the key steps in the induction of atherosclerotic lesions by increasing damage to the arterial side through several processes, including growth factor and chemotactic protein expression, inflammation, and build up local macrophages [120, 121] have indicated that ethanolic leaf extract of Ocimum basilicum L. oil strongly inhibits copper sulfate-induced oxidation of LDL, as a result of the step of different indicators of lipid oxidation [phospholipids (PL), cholesterol ester (CE), triacylglycerol (TG)].
Although the contraction of plasmatic cholesterol and LDL is the primary technique regulating the antiatherogenic activity of Ocimum basilicum L. extract, other implements are further identified [121]. It is well settled that local leukocyte and monocyte recruitment into the vessel wall is initial walk-in atherogenesis. This fact takes combined with the statement in the endothelial cells of adhesion fragments such as intercellular adhesion fragment-1 (ICAM-1) and vascular adhesion fragment-1 (VCAM-1). Aqueous extract of Ocimum gratissimum L. showed the capacity to reduce LPS-stimulated expression of BEAS-2B cell in human lung epithelial cells inhibiting its mRNA levels. Moreover, Li et al. [122], investigating the action of distillate and residue fractions of basil essential oil (viz. estragole, methyl eugenol, linoleic acid, α-cadinol, and α-bergamotene) in-a Raw 264.7 cells line, have demonstrated that residue fractions prevents the expression of gene and suppressed the production of cytokines (TNF-a, IL-b, IL-6) in LPS-induced Raw264.7 cells, which contribute to treating various disorders caused by extreme oxidative stress.
6.5 Anti-inflammatory
The inflammatory response involves long been compartmentalized into multiple attributes commonly termed redness, heat, pain, and edema. Inflammatory injuries lead to the discharge of a variety of fundamental mediators, cytokines, and chemokines that balance cellular infiltration that consequentially brings about resolving inflammatory response and restoration of tissue scrupulosity. However, immutable inflammatory stimuli or dysregulation of mechanisms of the resolution phase can lead to chronic inflammation [123, 124].
Ocimum extracts contain numerous constituents which could have anti-inflammatory effects. The anti-inflammatory effects of Ocimum oil phenolics, in RAW 264.7 macrophage cells have been described by Aye et al. [125]. When added to murine macrophages stimulated with bacterial lipopolysaccharide (LPS), Ocimum oil phenolics did not cause cytotoxicity in RAW 264.7 macrophage cells in vitro, as evaluated by a significant increase in the production of nitric oxide [125]. Additionally, NO is a significant inflammatory mediator generated by NOS (neuronal, inducible, and endothelial) under physiological and pathophysiological conditions [126]. It further serves as a crucial mediator during the inflammatory process. Enhanced NO production and iNOS expression contributes to the great cytotoxic function of LPS stimulated macrophages [127]. Thus, the reduction in NO production indicates the anti-inflammatory activities of the treatment in the cells. However, Ocimum basilicum L. ethyl acetate extract and butanol extract inhibited the growth of normal RAW 264.7 macrophage cells [128]. Also, Ocimum basilicum L. crude methanolic extract suppressed the induction of iNOS and the subsequent production of NO in LPS-stimulated RAW 264.7 macrophage cells [129, 130]. To test the anti-inflammatory activity of the Ocimum basilicum L. methanolic extracts has been determined by PBMC (peripheral blood mononuclear cells) in mitogenic lymphocyte proliferative assay, methanolic extracts enhanced the functional activity of these immune-competent cells, as evaluated by a significant inhibitory effects of methanolic leaf extracts, PHA activated PBMC proliferation could be suggestive of suppression of T cell proliferation [130]. This effect arose from its pivotal role in immune regulation [131, 132], T cell activation provides a target for pharmacological modulation aimed at achieving clinically useful immune-suppression [133].
Złote et al. [134] studied the capacity of phenolic-rich fraction obtained from the elicited basil leaves to inhibit the activity of two enzymes of inflammatory process (LOX and COX). This research found that a higher LOX and COX inhibition efficiency was positively correlated with the increased contents of rosmarinic, benzoic and o-coumaric acids determined after elicitation of basil. This result partially corresponds with the study of [135]. More recently, to gain insight into the mechanism of action and pharmacological value of the anti-inflammatory activity of aqueous and methanolic extracts of Ocimum basilicum L. in macrophage (RAW264.7) and human chondrosarcoma (SW1353) cell lines, and human primary chondrocytes to correlate their efficacy in terms of management of osteoarthritis (OA). Raina et al. [136] evaluated aqueous extract of O. basilicum L. significantly accustom the production of inflammatory mediators such as NO, PGE2, LTB4, and MMPs increased than the methanolic extract. The regulation of these inflammatory intermediaries is pivotal in OA, as it would have a direct effect on (1) chondrocyte survival, (2) production of proinflammatory cytokines, prostaglandins and leukotrienes, and (3) production of extracellular matrix-degrading enzymes such as MMPs. Due to the significant side-effects related to the use of NSAIDs, the check for natural products that would regulate the inflammatory cascade related to OA, without engaging chondrocyte survival, is extremely important. To investigate the anti-inflammatory effect of Ocimum basilicum L. oil, Rodrigues et al. [137] investigated an acute and chronic in vivo test as paw edema, peritonitis, and vascular permeability and granulomatous inflammation model. The anti-inflammatory mechanism of action was also analyzed by the participation of histamine and arachidonic acid pathways. These researchers found that the Ocimum basilicum L. essential oil and estragole significantly reduced paw edema induced by carrageenan and dextran. The smallest quantities of Ocimum basilicum L. essential oil (50 mg/kg) and estragole (30 mg/kg) revealed effectiveness in the decrease of paw edema created by histamine and arachidonic acid, vascular permeability inhibition and leukocyte emigration in the peritoneal fluid. These dosages were carried out of decrease the assured inflammatory process. The results followed between the Ocimum basilicum L. essential oil and estragole determine efficacy in anti-inflammatory activity, however, the essential oil is higher efficacious in the acute and chronic anti-inflammatory action. Dextran is a high molecular weight polysaccharide, which differently to carrageenan, induces anaphylactic reactions characterized by extravasation and formation of edema due to mastocyte degranulation with release of histamine and serotonin. Carrageenan induces an inflammatory response through opinion with sulfated polysaccharides, initially encouraging the free of chemical substances which encourage multifactorial facts, mostly concerning the free of substance P, bradykinin, histamine, serotonin, cytokines, and nitric oxide and, subsequently on commodity arise from the arachidonic acid pathway [138].
6.6 Antidiabetic
Diabetes mellitus is a chronic metabolic disorder caused by an absolute or relative lack of insulin and or reduced insulin activity which results in hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism [139, 140]. The hypoglycemic effect of O. tenuiflorum L., O. canum Sims. and O. gratissimum L. in animals with alloxan-induced diabetes was applied to potentiation of glucose-induced insulin free and parallel increased peripheral uptake of glucose [141, 142]. Successive studies have reported a greater link of antidiabetic deal with the antioxidant effects of Ocimum oil. The character played by OS for diabetes complications such as retinopathy, nephropathy, and cardiovascular disease are well set up so that dietary antioxidant compounds was fixed to protect from the damages of oxidative stress and free radicals in diabetic cases [143].
In animal experimental designs of alloxan-induced diabetes, both antioxidant and hypoglycemic effects of O. basilicum L., O. tenuiflorum L., O. canum Sims. and O. gratissimum L. have been reported. By treating alloxan-diabetic rabbits [141, 142, 144], made a significant decrease in blood glucose levels as corresponded with diabetic control rabbits. Such a hypoglycemic work was related to its powerful antioxidant potentiality: in evidence, in interact, the rabbits studied with Ocimum oil showed further a renewal of the levels of malondialdehyde and most of the enzymatic and nonenzymatic endogenous antioxidants [141, 142, 144]. Similar results were achieved in alloxan-diabetic rats: the control, of Ocimum tenuiflorum-rich extracts showed significant hypoglycemic, hypolipidemic, and antioxidant effects in all the investigated diabetic rats [145, 146]. In an identical empirical design, O. gratissimum L. led to a decrease in the sugar level in plasma and a rise in superoxide dismutase, catalase, and glutathione peroxidase activities in liver and kidney. Furthermore, an opposed reaction against hepatic and renal toxicity in diabetic rats was also observed [147, 148]. Furthermore, the effects of Ocimum sanctum leaf polyphenols have been investigated also in insulin-secreting pancreatic β-cells, whose OS-induced alterations contribute to the pathogenesis of diabetes [149].
7. Future direction and conclusion
Despite the many appreciations of science and industry, present practice is filled with stress. Mobile devices and the web have vastly enhanced the pace of life so that many people feel that they are now going down in an endless-increasing ocean of data, while technical culture has overwhelmed us with growing vulnerability to unhealthy prepared and packed food and a profusion of pesticides, food container components, and many toxic modern chemicals. Urban citizens are nevertheless dealt with growing prosperity disparity, social segregation, excessive turbulence, air, water and soil pollution and disconnection from nature. Therefore, while industrialization experiences served to stronger lifespans and impressive expansions in human populations, it is now agreed that the extremest causes of death and disease on the globe are preventable lifestyle-related chronic diseases [150].
The biodiversity of essential oils containing the small molecular terpenoids remains an enchanted field of investigation, and the continuous usage of this reward in a broad field of studies suggested these demands in the consequent [151]. Screening, identifying, and dealing with this vast biodiversity will require a progressing progress of precise, rich-throughput experimental methods including new driving procedures.
The beneficial health effects of Ocimum oil compounds have also been proven by many randomized, crossover, controlled, human studies on biomarkers of health performed in the last decades. Several preclinical studies suggest that such beneficial effects may be mainly ascribed to the phenolic compounds. Further development of biotechnology with the genomic and metabolomic analyses and genetic engineering will advance a variety of fields involving bioactive compounds ranging from food and animal nutrition to plant protection. Although many biological activities as antimicrobial or antioxidative and other effects have been intensively studied and well documented. However, well studies are needed to further characterize the in vivo effects of individual Ocimum derivatives applied as specific agents or in a mixture, consisting of their safety analysis on mortals. Moreover, a better evidence of their molecular procedure of activity may appropriate the system to a better application in human pharmacology.
In inference, the tendency of the last moments in the treatment of herbal productions have indicated that nature prospects and trust in pure and healthful products including medicines, cosmetics, household products, since easily as foodstuffs of plant and animal origin have belonged to a vital issue. So, indeed a well-balanced risk-benefit assessment of bioactive essential oils is one of the major challenges and policymakers must be convinced that review on natural products as the volatile terpenoids in essential oils is a huge task to ensure the ultimate human and animal welfare [151].
\n',keywords:"Ocimum sp., essential oil, composition, biological activity",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/68465.pdf",chapterXML:"https://mts.intechopen.com/source/xml/68465.xml",downloadPdfUrl:"/chapter/pdf-download/68465",previewPdfUrl:"/chapter/pdf-preview/68465",totalDownloads:1207,totalViews:0,totalCrossrefCites:3,dateSubmitted:"February 14th 2019",dateReviewed:"July 11th 2019",datePrePublished:"October 23rd 2019",datePublished:"February 12th 2020",dateFinished:"August 6th 2019",readingETA:"0",abstract:"The genus Ocimum (Lamiaceae) is distributed all over the world and can be found in many environments. Ocimum species is a rich source of various phytochemicals including tannins, phenolic acids, anthocyanins, phytosterols, and policosanols. These phytochemicals have the potential to significantly impact human health. The economic importance of Ocimum is also evident; Ocimum oil and its constituents and derivatives are used as flavoring agents throughout the world in food, pharmaceutical, herbal, perfumery, and flavoring industry. The important advantages of Ocimum plants in various treatments are their safety besides being less expensive, efficacy and availability throughout the world. This paper will focus on the biological effects of Ocimum essential oils, with particular attention on the molecular mechanism underlying their action.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/68465",risUrl:"/chapter/ris/68465",signatures:"Debjoy Bhattacharjya, Sinchan Adhikari, Arijit Biswas, Anil Bhuimali, Parthadeb Ghosh and Soumen Saha",book:{id:"8077",type:"book",title:"Phytochemicals in Human Health",subtitle:null,fullTitle:"Phytochemicals in Human Health",slug:"phytochemicals-in-human-health",publishedDate:"February 12th 2020",bookSignature:"Venketeshwer Rao, Dennis Mans and Leticia Rao",coverURL:"https://cdn.intechopen.com/books/images_new/8077.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-588-3",printIsbn:"978-1-78985-587-6",pdfIsbn:"978-1-83968-413-5",isAvailableForWebshopOrdering:!0,editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Health benefits of phytochemicals",level:"1"},{id:"sec_3",title:"3. Role of secondary metabolites",level:"1"},{id:"sec_4",title:"4. Classification of secondary metabolites",level:"1"},{id:"sec_5",title:"5. Essential oil of Ocimum species",level:"1"},{id:"sec_6",title:"6. Biological activities of Ocimum species",level:"1"},{id:"sec_6_2",title:"6.1 Oxidant activity",level:"2"},{id:"sec_7_2",title:"6.2 Antimicrobial",level:"2"},{id:"sec_8_2",title:"6.3 Anticancer activity",level:"2"},{id:"sec_9_2",title:"6.4 Cardiovascular protection",level:"2"},{id:"sec_10_2",title:"6.5 Anti-inflammatory",level:"2"},{id:"sec_11_2",title:"6.6 Antidiabetic",level:"2"},{id:"sec_13",title:"7. Future direction and conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Kunwar RM, Adhikari N. Ethnomedicine of Dolpa district, Nepal: The plants, their vernacular names and uses. Lyonia. 2005;8:43-49'},{id:"B2",body:'UNESCO. FIT/504-RAF-48 Terminal Report: Promotion of Ethnobotany and the Sustainable Use of Plant Resources in Africa; Paris. 1998. p. 60'},{id:"B3",body:'Idu M, Umweni AA, Odaro T, Ojelede L. Ethnobotanical plants used for oral healthcare among the Esan Tribe of Edo State, Nigeria. Ethnobotanical Leaflets. 2009;13:548-563'},{id:"B4",body:'Danesi F, Elementi S, Neri R, Maranesi M, D’antuono LF, Bordoni A. Effect of cultivar on the protection of cardiomyocytes from oxidative stress by essential oils and aqueous extracts of basil (Ocimum basilicum L.). Journal of Agriculture & Food Chemistry. 2008;56:9911-9917'},{id:"B5",body:'Joshi V, Bothara B, Surana J. Evaluation of aqueous extract of Ocimum sanctum in experimentally induced parkinsonism. Journal of Chemical and Pharmaceutical Research. 2011;3:478-487'},{id:"B6",body:'Velioglu YS, Mazza G, Gao L, Oomah BD. Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. Journal of Agricultural Food & Chemistry. 1998;46:4113-4117'},{id:"B7",body:'Cross CE, Halliwell B, Borish ET. Oxygen radicals and human disease. An International Medicine. 1987;107:526-545'},{id:"B8",body:'Liu RH. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. Journal of Nutrition. 2004;134:3479S-3485S'},{id:"B9",body:'Xi P, Liu RH. Whole food approach for type 2 diabetes prevention. Molecular Nutrition & Food Research. 2016;60:1819-1836'},{id:"B10",body:'Balunasa MJ, Kinghorn D. Drug discovery from medicinal plants. Life Sciences. 2005;78:431-441'},{id:"B11",body:'Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products. 2016;79:629-661'},{id:"B12",body:'Dudareva N, Klempien A, Muhlemann JK, Kaplan I. Biosynthesis, function and metabolic engineering of plant organic volatile compounds. New Phytologist. 2013;198:16-32'},{id:"B13",body:'Herbert RB, editor. The Biosynthesis of Secondary Metabolites. 2nd ed. Chapman & Hall: London; 1989'},{id:"B14",body:'Nolaou KC, Chen JS, Corey EJ. Classics in Total Synthesis, Further Targets, Strategies, Methods III. Weinheim: Wiley; 2011. pp. 1-770'},{id:"B15",body:'Verpoorte R. Secondary metabolism. In: Verpoorte R, Alfermann AW, editors. Metabolic Engineering of Plant Secondary Metabolism. Springer: Dordrecht; 2000'},{id:"B16",body:'Wei A, Shibamoto T. Antioxidant/Lipoxygenase inhibitory activities and chemical compositions of selected essential oil. Journal of Agriculture and Food Chemistry. 2010;58:7218-7225'},{id:"B17",body:'Bradu BL, Sobti SN, Pushpangadan P, Khosla KM, Rao BL, Gupta SC. Development of superior alternate source of clove oil from ‘Clocimum’ (Ocimum gratissimum Linn.). In: Proc. 11th Int. Congr. of Essential Oils, Fragrances and Flavours. Vol. 3. 1989. pp. 97-103'},{id:"B18",body:'Chang X, Alderson PG, Wright CJ. Enhanced UV-B radiation alters basil (Ocimum basilicum L.) growth and stimulates the synthesis of volatile oils. Journal of Horticulture and Forestry. 2009;1:027-031'},{id:"B19",body:'Martino LD, Feo VD, Nazzaro F. Chemical composition and in vitro antimicrobial and mutagenic activities of seven Lamiaceae essential oils. Molecules. 2009;14:4213-4230'},{id:"B20",body:'Ismail M. Central properties and chemical composition of Ocimum basilicum essential oil. Pharmaceutical Biology. 2006;44:619-626'},{id:"B21",body:'Lee SJ, Umano K, Shibamoto T, Lee KG. Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. Food Chemistry. 2005;91:131-137'},{id:"B22",body:'Hassanpouraghdam MB, Gohari GR, Tabatabaei SJ, Dadpour MR Inflorescence and leaves essential oil composition of hydroponically grown Ocimum basilicum L. Journal of the Serbian Chemical Society. 2010;75:1361-1368'},{id:"B23",body:'Lawrance BM, Mokheyee BD, Willis BJ. Developments in Food Sciences, Flavour and Fragrances; A World Perspective. The Netherlands: Elsevier; 1988'},{id:"B24",body:'Bassolé IH, Lamien-Meda A, Bayala B, Tirogo S, Franz C, Novak J, et al. Composition and antimicrobial activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. essential oils and their major monoterpene alcohols alone and in combination. Molecules. 2010;15:7825-7839'},{id:"B25",body:'Vani SR, Cheng SF, Chuah CH. Comparative study of volatile compounds from genus Ocimum. American Journal of Applied Sciences. 2009;6:523-528'},{id:"B26",body:'Özcan M, Chalchat JC. Essential oil composition of Ocimum basilicum L. and Ocimum minimum L. in Turkey. Czech Journal of Food Science. 2002;20:223-228'},{id:"B27",body:'Poonkodi K. Chemical composition of essential oil of Ocimum Basilicum L. (basil) and its biological activities—An overview. Journal of Critical Reviews. 2016;3:56-62'},{id:"B28",body:'Pandey AK, Singh P, Tripathi NN. Chemistry and bioactivities of essential oils of some Ocimum species: An overview. Asian Pacific Journal of Tropical Biomedicine. 2014;4:682-694'},{id:"B29",body:'Saha S, Dhar TN, Sengupta C, Ghosh PD. Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria. Czech Journal of Food Science. 2013;31:194-202'},{id:"B30",body:'Joshi RK. Chemical composition of the essential oil of camphor basil (Ocimum kilimandscharicum Guerke). Global Journal of Medicinal Plant Research. 2013;1:207-209'},{id:"B31",body:'Mahesh SP, Patil MB, Kumar R, Patil SR. Evaluation of aqueous extract of leaves if Ocimum kilimandscharicum Guerke wound healing activity in albino wistar rats. International Journal of Pharmtech Research Coden (USA). 2009;1:544-550'},{id:"B32",body:'Kashyap CP, Kaur R, Arya V, Vipin K. Therapeutic potency of Ocimum kilimandscharicum Guerke—A review. Global Journal of Pharmacology. 2011;5:191-200'},{id:"B33",body:'Dolly G, Nidhi S, Bps S, Shweta R, Shikha A. Ocimum kilimandscharicum: A systematic review. Journal of Drug Delivery & Therapeutics. 2012;2:45-52'},{id:"B34",body:'Charles DJ, Simon JE. Essential oil constituents of Ocimum kilimandscharicum Guerke. Journal of Essential Oil Research. 1992;4:125-128'},{id:"B35",body:'Matasyoh LG, Matasyoh JC, Wachira FN, Kinyua MG, Muigai AWT, Mukiama TK. Chemical composition and antimicrobial activity of the essential oil of Ocimum gratissimum L. growing in Eastern Kenya. African Journal of Biotechnology. 2007;6:760-765'},{id:"B36",body:'Ntezurubanza L, Scheffer JJC, Svendsen AB. Composition of the essential oil of Ocimum gratissimum grown in Rwanda. Planta Medica. 1987;53:421-423'},{id:"B37",body:'Chimnoi N, Reuk-ngam N, Chuysinuan P, Khlaychan P, Khunnawutmanotham N, Chokchaichamnankit D, et al. Characterization of essential oil from Ocimum gratissimum leaves: Antibacterial and mode of action against selected gastroenteritis pathogens. Microbial Pathogenesis. 2018;118:290-300'},{id:"B38",body:'Nguemtchouin MGM, Ngassoum MB, Chalier P, Kamga R, Ngamo LST, Cretin M. Ocimum gratissimum essential oil and modified montmorillonite clay, a means of controlling insect pests in stored products. Journal of Stored Products Research. 2013;52:57-62'},{id:"B39",body:'Nakamura CV, Ueda-Nakamura T, Bando E, Melo AFN, Cortez DAG, Filho BPD. Antibacterial activity of Ocimum gratissimum L. essential oil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro. 1999;94:675-678'},{id:"B40",body:'Vieiraa RF, Grayerb RJ, Patonb A, Simona JE. Genetic diversity of Ocimum gratissimum L. based on volatile oil constituents, flavonoids and RAPD markers. Biochemical Systematics and Ecology. 2001;29:287-304'},{id:"B41",body:'Pessoaa LM, Moraisb SM, Bevilaquaa CML, Lucianob JHS. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Veterinary Parasitology. 2002;109:59-63'},{id:"B42",body:'Belong P, Ntonga PA, Fils EMB, Dadji GAF, Tamesse JL. Chemical composition and residue activities of Ocimum canum Sims and Ocimum basilicum L essential oils on adult female Anopheles funestus ss. Journal of Animal & Plant Sciences. 2013;19:2854-2863'},{id:"B43",body:'Kalita J, Khan ML. Commercial potentialities of essential oil of Ocimum members growing in north East India. International Journal of Pharmacy & Life Sciences. 2013;4:2559-2567'},{id:"B44",body:'Ntonga PA, Baldovini N, Mouray E, Mambu L, Belong P, Grellier P. Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s. Parasite. 2014;21:33'},{id:"B45",body:'Selvi MT, Thirugnanasampandan R, Sundarammal S. Antioxidant and cytotoxic activities of essential oil of Ocimum canum Sims. from India. Journal of Saudi Chemical Society. 2012;19:97-100'},{id:"B46",body:'Chagonda LS, Makanda CD, Chalchat JC. The essential oils of Ocimum canum Sims (basilic camphor) and Ocimum urticifolia Roth from Zimbabwe. Flavour and Fragrance Journal. 2000;15:23-26'},{id:"B47",body:'da Silvaa VD, Almeida-Souzab F, Teles AM, Neto PA, Mondego-Oliveira R, Filho NEM, et al. Chemical composition of Ocimum canum Sims. essential oil and the antimicrobial, antiprotozoal and ultrastructural alterations it induces in Leishmania amazonensis promastigote. Industrial Crops and Products. 2018;119:201-208'},{id:"B48",body:'Olugbade TA, Kolipha-Kamara MI, Elusiyan CA, Onawunmi GO, Ogundaini AO. Essential oil chemotypes of three Ocimum species found in Sierra Leone and Nigeria. Medicinal & Aromatic Plants. 2017;6:284. DOI: 10.4172/2167-0412.1000284'},{id:"B49",body:'Tonzibo ZF, Chalchat JC, N’Guessan YT. Chemical composition of essential oils of Ocimum canum Sims from Côte d’Ivoire. Journal of Essential Oil Bearing Plants. 2008;11:530-535'},{id:"B50",body:'Khan A, Ahmad A, Akhtar F, Yousuf S, Xess I, Khan LA, et al. Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. Research in Microbiology. 2010;161:816-823'},{id:"B51",body:'Kicel A, Kurowska A, Kalemba D. Composition of the essential oil of Ocimum sanctum L. grown in poland during vegetation. Journal of Essential Oil Research. 2005;17:217-219'},{id:"B52",body:'Ijaz B, Hanif MA, Mushtaq Z, Khan MM, Bhatti IA, Jilani MJ. Isolation of bioactive fractions from Ocimum Sanctum essential oil. Oxidation Communications. 2017;40:158-167'},{id:"B53",body:'Saroj T, Krishna A. A comparison of chemical composition and yield of essential oils from shoot system parts of Ocimum sanctum found in semi-arid region of Uttar Pradesh. Agrotechnology. 2017;6:172. DOI: 10.4172/2168-9881.1000172'},{id:"B54",body:'Kumar A, Shukla R, Singh P, Dubey NK. Chemical composition, antifungal and antiaflatoxigenic activities of Ocimum sanctum L. essential oil and its safety assessment as plant based antimicrobial. Food and Chemical Toxicology. 2010;48:539-543'},{id:"B55",body:'Sims CA, Juliani HR, Mentreddy SR, Simon JE. Essential oils in holy basil (Ocimum tenuiflorum L.) as influenced by planting dates and harvest times in North Alabama. Journal of Medicinally Active Plants. 2014;2:33-41'},{id:"B56",body:'Pino JA, Rosado A, Rodriguez M, Garcia D. Composition of the essential oil of Ocimum tenuiflorum L. grown in Cuba. Journal of Essential Oil Research. 1998;10:437-438'},{id:"B57",body:'Brophy JJ, Goldsack RJ, Clarkson JR. The essential oil of Ocimum tenuiflorum L. (Lamiaceae) growing in northern Australia. Journal of Essential Oil Research. 1993;5:459-461'},{id:"B58",body:'Yamani HA, Pang EC, Mantri N, Deighton MA. Antimicrobial activity of Tulsi (Ocimum tenuiflorum) essential oil and their major constituents against three species of bacteria. Frontiers in Microbiology. 2016;7:681. DOI: 10.3389/fmicb.2016.00681'},{id:"B59",body:'Raina AP, Kumar A, Dutta M. Chemical characterization of aroma compounds in essential oil isolated from “holy basil” (Ocimum tenuiflorum L.) grown in India. Genetic Resources and Crop Evolution. 2013;60:1727-1735'},{id:"B60",body:'Sharma V, Sharma A, Seth R. A study on Antidermatophytic potential of Ocimum tenuiflorum essential oil and chemical composition evaluation. International Journal of PharmTech Research. 2016;9:151-160'},{id:"B61",body:'Tangpao T, Chung HH, Sommano SR. Aromatic profiles of essential oils from five commonly used Thai basils. Food. 2018;7:175. DOI: 10.3390/foods7110175'},{id:"B62",body:'Ismail HI, Chan KW, Marion AA, Ismail M. Phenotic content and antioxidanat activity of cantoloupe (Cucumis melol) methanolic extracts. Food Chemistry. 2010;119:643-647'},{id:"B63",body:'Ismail A, Margan ZM, Foong CW. Total activity and phenolic content in selected vegetables. Food Chemistry. 2004;87:581-586'},{id:"B64",body:'Rice-Evans CA, Diplock AT. Current status of antioxidant therapy. Free Radical Biology & Medicine. 1993;15:77-96'},{id:"B65",body:'Brewer MS. Natural antioxidants: Sources, compounds, mechanisms of action, and potential applications. Comprehensive Reviews in Food Science and Food Safety. 2011;10:221-247'},{id:"B66",body:'Barroso MF, Ramalhosa MJ, Alves RC, Dias A, Soares CMD, OlivaTeles MT, et al. Total antioxidant capacity of plant infusions: Assessment using electrochemical DNA-based biosensor and spectrophotometric methods. Food Control. 2016;68:153-161'},{id:"B67",body:'Hakkim FL, Arivazhagan G, Boopathy R. Antioxidant property of selected Ocimum species and their secondary metabolite content. Journal of Medicinal Plants Research. 2008;2:250-257'},{id:"B68",body:'Filip S, Vidović S, Vladić J, Pavlić B, Adamović D, Zeković Z. Chemical composition and antioxidant properties of Ocimum basilicum L. extracts obtained by supercritical carbon dioxide extraction: Drug exhausting method. The Journal of Supercritical Fluids. 2016;109:20-25'},{id:"B69",body:'Bhattacharya A, Aggarwal A, Sharma N, Cheema J. Evaluation of some anti-oxidative constituents of three species of Ocimum. International Journal of Life Sciences. 2014;8:14-17'},{id:"B70",body:'Pripdeevech P, Chumpolsri W, Suttiarporn P, Wongpornchai S. The chemical composition and antioxidant activities of basil from Thailand using retention indices and comprehensive two-dimensional gas chromatography. Journal of Serbian Chemical Society. 2010;75:1503-1513'},{id:"B71",body:'Kwee EM, Niemeyer ED. Variations in phenolic composition and antioxidant properties among 15 basil (Ocimum basilicum L.) cultivars. Food Chemistry. 2011;128:1044-1050'},{id:"B72",body:'Farouk A, Fikry R, Mohsen M. Chemical composition and antioxidant activity of Ocimum basilicum L. essential oil cultivated in Madinah Monawara, Saudi Arabia and its comparison to the Egyptian Chemotype. Journal of Essential Oil Bearing Plants. 2016;19:1119-1128'},{id:"B73",body:'Falowo AB, Mukumbo FE, Idamokoro EM, Afolayan AJ, Muchenje V. Phytochemical constituents and antioxidant activity of sweet basil (Ocimum basilicum L.) essential oil on ground beef from Boran and Nguni Cattle. International Journal of Food Science. 2019;9:1-8'},{id:"B74",body:'Suanarunsawat T, Ayutthaya WDN, Songsak T, Thirawarapan S, Poungshompoo S. Lipid-lowering and antioxidative activities of aqueous extracts of Ocimum sanctum L. leaves in rats fed with a high-cholesterol diet. Oxidative Medicine and Cellular Longevity. 2011;1:1-9'},{id:"B75",body:'Cohen MM. Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda & Integrative Medicine. 2014;5:251-259'},{id:"B76",body:'Jayasinghe C, Gotoh N, Aoki T, Wada S. Phenolics composition and antioxidant activity of sweet basil (Ocimum basilicum L.). Journal of Agriculture and Food Chemistry. 2003;51:4442-4449'},{id:"B77",body:'Subramanian M, Chintalwar GJ, Chattopadhyay S. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Redox Report. 2005;10:257-264'},{id:"B78",body:'Mahapatra SK, Roy S. Phytopharmacological approach of free radical scavenging and antioxidative potential of eugenol and Ocimum gratissimum Linn. Asian Pacific Journal of Tropical Medicine. 2014;7:S391-S397'},{id:"B79",body:'Nahak G, Mishra RC, Sahu RK. Phytochemical investigation and in vitro antioxidant evaluation of some Ocimum species. Journal of Pharmacy Research. 2011;4:2340-2343'},{id:"B80",body:'Tewari D, Pandey HK, Sah AN, Meena H, Chander V, Singh R, et al. Phytochemical, antioxidant and antidepressant evaluation of Ocimum basilicum, O. tenuiflorum, O. kilimandscharicum grown in India. Journal of Biologically Active Products from Nature. 2015;5:120-131'},{id:"B81",body:'Omodamiro OD, Jimoh MA. Antioxidant and antibacterial activities of Ocimum gratissimum. American Journal of Phytomedicine and Clinical Therapeutics. 2015;3:010-019'},{id:"B82",body:'Venuprasad MP, Kandikattu HK, Razack S, Khanum F. Phytochemical analysis of Ocimum gratissimum by LC-ESI–MS/MS and its antioxidant and anxiolytic effects. South African Journal of Botany. 2014;92:151-158'},{id:"B83",body:'Tanuj J, Vijay J. Antioxidant activity of ethanolic extract of Ocimum Kilimandscharicum using hydroxyl radical scavenging method. Journal of Drug Delivery and Therapeutics. 2017;7:66-68'},{id:"B84",body:'Jamshidi N, Cohen MM. The clinical efficacy and safety of Tulsi in humans: A systematic review of the literature. Evidence-Based Complementary and Alternative Medicine. 2017;1:1-13'},{id:"B85",body:'Samak G, Rao MS, Kedlaya R, Vasudevan DM. Hypolipidemic efficacy of Ocimum Sanctum in the prevention of atherogenesis in male albino rabbits. Pharmacology. 2007;2:115-127'},{id:"B86",body:'Mirje MM, Zaman SU, Ramabhimaiah S. Evaluation of the anti-inflammatory activity of Ocimum sanctum Linn (Tulsi) in albino rats. International Journal of Current Microbiology and Applied Sciences. 2014;3:198-205'},{id:"B87",body:'Güez CM, de Souza RO, Fischer P, de Moura Leão MF, Duarte JA, Boligon AA, et al. Evaluation of basil extract (Ocimum basilicum L.) on oxidative, antigenotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents. Brazilian Journal of Pharmaceutical Sciences. 2017;53:e15098'},{id:"B88",body:'Eldin HME, Badawy AF. In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil. Journal of Parasitic Diseases. 2015;39:465-473'},{id:"B89",body:'de Lima Silva L, Garlet QI, Koakoski G, de Abreu MS, Mallmann CA, Baldisserotto B, et al. Anesthetic activity of the essential oil of Ocimum americanum in Rhamdia quelen (Quoy & Gaimard, 1824) and its effects on stress parameters. Neotropical Ichthyology. 2015;13:715-722'},{id:"B90",body:'Caamal-Herrera SO, Carrillo-Cocom LM, Escalante-Réndiz DY, Aráiz-Hernández D, Azamar-Barrios JA. Antimicrobial and antiproliferative activity of essential oil, aqueous and ethanolic extracts of Ocimum micranthum Willd leaves. BMC Complementary and Alternative Medicine. 2018;18:55'},{id:"B91",body:'Dorman HJD, Deans SG. Antimicrobial agents from plants: Antibacterial activity of plant volatile oils. Journal of Applied Microbiology. 2000;88:308-316'},{id:"B92",body:'Burt S. Essential oils: Their antibacterial properties and potential applications in foods—A review. International Journal of Food Microbiology. 2004;94:223-253'},{id:"B93",body:'Schmidt N, Mishra A, Lai GH, Wong GCL. Arginine-rich cell-penetrating peptides. FEBS Letter. 2010;584:1806-1813'},{id:"B94",body:'Londhe AM, Kulkarni AS, Lawand RV. In-vitro comparative study of antibacterial and antifungal activities: A case study of Ocimum kilimandscharicum, Ocimum tenuiflorum and Ocimum gratissimum. International Journal of Pharmacognosy and Phytochemical Research. 2015;7:104-110'},{id:"B95",body:'Miller AB, Cates RG, Lawrence M, Soria JAF, Espinoza LV, Martinez JV, et al. The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plants. Pharmaceutical Biology. 2014;53:548-554'},{id:"B96",body:'Pandey S. Antibacterial and antifungal activities of Ocimum gratissimum L. International Journal of Pharmacy and Pharmaceutical Sciences. 2017;9:26-31'},{id:"B97",body:'Wagura AG, Kimenju JW, Gichimu BM. Comparative antibacterial effects of raw and essential oils of Ocimum gratissimum L. against Ralstonia solanacearum (Smith). International Journal of Plant Pathology. 2011;2:144-152'},{id:"B98",body:'Chenni M, Abed DE, Rakotomanomana N, Fernandez X, Chemat F. Comparative study of essential oils extracted from Egyptian basil leaves (Ocimum basilicum L.) using hydro-distillation and solvent-free microwave extraction. Molecules. 2016;21:113'},{id:"B99",body:'Chouhan S, Sharma K, Guleria S. Antimicrobial activity of some essential oils-present status and future perspectives. Medicine. 2017;4:58'},{id:"B100",body:'Eswar P, Devaraj CG, Agarwal P. Anti-microbial activity of Tulsi {Ocimum Sanctum (Linn.)} extract on a periodontal pathogen in human dental plaque: An in vitro study. Journal of Clinical and Diagnostic Research. 2016;10:ZC53-ZC56'},{id:"B101",body:'Mondal S. Antimicrobial and Immunomodulatory effects of Tulsi (Ocimum sanctum Linn) [thesis]. Faculty of All India Institute of Medical Sciences, New Delhi, India for the award of the degree of Doctor of Philosophy. 2010. pp. 1-141'},{id:"B102",body:'Carovic-Stanko K, Orlić S, Politeo O, Strikić F, Kolak I, Milos M, et al. Composition and antibacterial activities of essential oils of seven Ocimum taxa. Food Chemistry. 2010;119:196-201'},{id:"B103",body:'El-Soud NHA, Deabes M, El-Kassem LA, Khalil M. Chemical composition and antifungal activity of Ocimum basilicum L. essential oil. Open Access Macedonian Journal of Medical Science. 2015;3:374-379'},{id:"B104",body:'Warrier PK, Nambair VPK, Ramankutty C. Indian Medicinal Plants: A Compendium of 500 Species. Arya Vaidya Sala, Kottakal, Kerala: Orient Longman, India; 1995'},{id:"B105",body:'Behbahani M. Evaluation of in vitro anticancer activity of Ocimum basilicum, Alhagi maurorum, Calendula officinalis and their parasite Cuscuta campestris. PLoS One. 2014;9:e116049. DOI: 10.1371/journal.pone.0116049'},{id:"B106",body:'Mohammadi M, Majd A, Nejadsattari T, Hashemi M. Antioxidant and anticancer activities of Ocimum basilicum L. cv. Dark Opal (Lamiaceae). Pharmacognosy Communications. 2014;4:48-58'},{id:"B107",body:'Naidu JR, Gunjan M, Chen Y, Sasidharan S. Evaluation of in vitro cytotoxic activity of Ocimum basilicum and Mentha spicata extracts. Asian Journal of Pharmaceutical and Clinical Research. 2016;9:131-134'},{id:"B108",body:'Zarlaha A, Kourkoumelis N, Stanojkovic TP, Kovala-Demertzi D. Cytotoxic activity of essential oil and extracts of Ocimum basilicum against human carcinoma cells. Molecular docking study of isoeugenol as a potent cox and lox inhibitor. Digest Journal of Nanomaterials and Biostructures. 2014;9:907-917'},{id:"B109",body:'Karthikeyan K, Gunasekaran P, Ramamurthy N, Govindasamy S. Anticancer activity of Ocimum sanctum. Pharmaceutical Biology. 1999;37:285-290'},{id:"B110",body:'Monga J, Sharma M, Tailor N, Ganesh N. Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species of Ocimum in C57BL mice. Pharmaceutical Biology. 2011;49:428-436'},{id:"B111",body:'de Lima VT, Vieirab MC, Kassuyac CAL, Cardosod CAL, Alvesa JM, Foglioe MA, et al. Chemical composition and free radical-scavenging, anticancer and anti-inflammatory activities of the essential oil from Ocimum kilimandscharicum. Phytomedicine. 2014;21:1298-1302'},{id:"B112",body:'Goel HC, Roa AR. Radiosensitizing effect of camphor on transplantable mammary adenocarcinoma in mice. Cancer Letters. 1988;43:21-27'},{id:"B113",body:'Banerjee S, Welsch CW, Rao AR. Modulatory influence of camphor on the activities of hepatic carcinogen metabolizing enzymes and the levels of hepatic and extrahepatic reduced glutathione in mice. Cancer Letters. 1995;88:163-169'},{id:"B114",body:'Ghant VK, Hiramoto NS, Solvason HB, Tyring SK, Spector NH, Hiramoto RN. Conditioned enhancement of natural killer cell activity, but not interferon, with camphor or saccharin-LiCl conditioned stimulus. Journal of Neuroscience Research. 1987;18:10-15'},{id:"B115",body:'Samant SS, Dhar U. Diversity, endemism and economic potential of wild edible plants of Indian Himalaya. International Journal of Sustainable Development & World Ecology. 2002;4:179-191'},{id:"B116",body:'Muralidharan A, Dhananjayan R. Cardiac stimulant activity of Ocimum basilicum Linn. extracts. Indian Journal of Pharmacology. 2004;36:163-166'},{id:"B117",body:'Dupasquier CM, Dibrov E, Kneesh AL, Cheung PKM, Lee KGY, Alexander HK, et al. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. American Journal of Physiology-Heart and Circulatory Physiology. 2007;293:2394-2402'},{id:"B118",body:'Amrania S, Harnafi H, Gadi D, Mekhfi H, Legssyer A, Aziz M, et al. Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract. Journal of Ethnopharmacology. 2009;125:157-162'},{id:"B119",body:'Janbaz KH, Hamid I, Gilani AH, Qadir MI. Spasmolytic, bronchodilator and vasodilator activities of Aqueousmethanolic extract of Ocimum basilicum. International Journal of Agriculture & Biology. 2014;16:321-327'},{id:"B120",body:'Packard RR, Maganto-Garcia E, Gotsman I, Tabas I, Libby P, Lichtman AH. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circulation Research. 2008;103:965-973'},{id:"B121",body:'Bravo E, Amrani S, Aziz M, Harnafi H, Napolitano M. Ocimum basilicum ethanolic extract decreases cholesterol synthesis and lipid accumulation in human macrophages. Fitoterapia. 2008;79:515-523'},{id:"B122",body:'Li H, Ge Y, Luo Z, Zhou Y, Zhang X, Zhang J, et al. Evaluation of the chemical composition, antioxidant and anti-inflammatory activities of distillate and residue fractions of sweet basil essential oil. Journal of Food Science and Technology. 2017;54:1882-1890'},{id:"B123",body:'Perretti M, D’Acquisto F. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nature Reviews. 2009;9:63-70'},{id:"B124",body:'D’Acquisto F, Maione F, Pederzoli-Ribeil M. From IL-15 to IL-33: The never-ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead? Biochemical Pharmacology. 2010;79:525-534'},{id:"B125",body:'Aye A, Jeon YD, Lee JH, Bang KS, Jin JS. Anti-inflammatory activity of ethanol extract of leaf and leaf callus of basil (Ocimum basilicum L.) on RAW 264.7 macrophage cells. Oriental Pharmacy and Experimental Medicine. 2019;19:217-226'},{id:"B126",body:'Kim HW, Roh DH, Yoon SY, Kang SY, Kwon YB, Han HJ, et al. The anti-inflammatory effects of low- and high-frequency electroacupuncture are mediated by peripheral opioids in a mouse air pouch inflammation model. Journal of Alternative and Complementary Medicine. 2006;12:39-44'},{id:"B127",body:'Son JK, Son MJ, Lee EK, Moon TC, Son KH, Kim CH, et al. Ginkgetin, a biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Biological and Pharmaceutical Bulletin. 2005;28:2181-2184'},{id:"B128",body:'Happar M, Tursun A, Wen-ting Z, Lu-feng C, Tohti I, Reyim N, et al. Efect of extracts of Ocimum basilicum L. on mouse macrophage raw 264.7 and 5-lipoxygenase. Chinese Traditional Patent Medicine. 2013;35:1599-1604'},{id:"B129",body:'Benedec D, Pârvu AE, Oniga I, Toiu A, Tiperciuc B. Effects of Ocimum Basilicum L. extract on experimental acute inflammation. Revista Medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 2007;111:1065-1069'},{id:"B130",body:'Selvakkumar C, Gayathri B, Vinaykumar KS, Lakshmi BS, Balakrishnan A. Potential anti-inflammatory properties of crude alcoholic extract of Ocimum basilicum L. in human peripheral blood mononuclear cells. Journal of Health Science. 2007;53:500-505'},{id:"B131",body:'Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nature Reviews Immunology. 2002;2:933-944'},{id:"B132",body:'Ranjan D, Chen C, Johnston TD, Jeon H, Nagabhushan M. Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkB activation, and IL-2 signaling. Journal of Surgical Research. 2004;121:171-177'},{id:"B133",body:'Van Den Brande JM, Peppelenbosch MP, Van Deventer SJ. Treating Crohn’s disease by inducing T lymphocyte apoptosis. Annals of the New York Academy of Sciences. 2002;973:166-180'},{id:"B134",body:'Złotek U, Szymanowska U, Karaś M, Świeca M. Antioxidative and anti-inflammatory potential of phenolics from purple basil (Ocimum basilicum L.) leaves induced by jasmonic, arachidonic and β-aminobutyric acid elicitation. International Journal of Food Science and Technology. 2016;51:163-170'},{id:"B135",body:'Gawlik-Dziki U, Świeca M, Sugier D. Enhancement of antioxidant abilities and the lipoxygenase and xanthine oxidase inhibitory activity of broccoli sprouts of biotic elicitors. Acta Scientiarum Polonorum, Hortorum Cultus. 2012;11:13-25'},{id:"B136",body:'Raina P, Deepak M, Chandrasekaran CV, Agarwal A, Wagh N, Kaul-Ghanekar R. Comparative analysis of anti-inflammatory activity of aqueous and methanolic extracts of Ocimum basilicum in RAW264.7, SW1353 and human primary chondrocytes. Journal of Herbal Medicine. 2016;6:28-36'},{id:"B137",body:'Rodrigues LB, Martins AOBPB, Ceśario FRAS, Castro FF, Albuquerque TR, Fernandes MNM, et al. Anti-inflammatory and antiedematogenic activity of the Ocimum basilicum essential oil and its main compound estragole: In vivo mouse models. Chemico-Biological Interactions. 2016;257:14-25'},{id:"B138",body:'Coelho CF, Vieira RP, Lopes-Martins PSL, Aparecida S, Teixeira AUB, Gouvea IM, et al. The effect of inhaled nitric oxide on the carrageenan-induced paw edema. Histology and Histopathology. 2015;30:117-124'},{id:"B139",body:'Boyle JP, Honeycutt AA, Venkat Narayan KM, Hoerger TJ, Geiss LS, Chen H, et al. Projection of Diabetes Burden Through 2050: Impact of changing demography and disease prevalence in the U.S. Diabetes Care. 2001;24:1936-1940'},{id:"B140",body:'Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-1053'},{id:"B141",body:'Mousavi L, Salleh RM, Murugaiyah V, Asmawi MZ. Hypoglycemic and anti-hyperglycemic study of Ocimum tenuiflorum L. leaves extract in normal and streptozotocin-induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine. 2016;6:1029-1036'},{id:"B142",body:'El-Beshbishy HA, Bahashwan SA. Hypoglycemic effect of basil (Ocimum basilicum) aqueous extract is mediated through inhibition of α-glucosidase and α-amylase activities: An in vitro study. Toxicology and Industrial Health. 2012;28:42-50'},{id:"B143",body:'Lean ME, Noroozi M, Kell L, Burns J, Talwar D, Sattar N, et al. Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes. 1999;48:176-181'},{id:"B144",body:'Bihari CG, Manaswini B, Keshari PS, Kumar TS. Phytochemical investigation & evaluation for antidiabetic activity of leafy extracts of various Ocimum (Tulsi) species by alloxan induced diabetic model. Journal of Pharmacy Research. 2011;4:28-29'},{id:"B145",body:'Parasuraman S, Balamurugan S, Christapher PV, Petchi RR, Yeng WY, Sujithra J, et al. Evaluation of antidiabetic and antihyperlipidemic effects of hydroalcoholic extract of leaves of Ocimum tenuiflorum (Lamiaceae) and prediction of biological activity of its Phytoconstituents. Pharmacognosy Research. 2015;7:156-165'},{id:"B146",body:'Egesie UG, Ibu ABAJO, Egesie OJ. Safety and hypoglycaemic properties of aqueous leaf extract of Ocimum Gratissimum in Streptozotocin induced diabetic rats. Nigerian Journal of Physiological Sciences. 2006;21:31-35'},{id:"B147",body:'Ezeani C, Ezenyi I, Okoye T, Okoli C. Ocimum basilicum extract exhibits antidiabetic effects via inhibition of hepatic glucose mobilization and carbohydrate metabolizing enzymes. Journal of Intercultural Ethnopharmacology. 2017;6:22-28'},{id:"B148",body:'Okoduwa SIR, Umar IA, James DB, Inuwa HM. Anti-diabetic potential of Ocimum gratissimum leaf fractions in fortified diet-fed Streptozotocin treated rat model of Type-2 diabetes. Medicine. 2017;4:1-21'},{id:"B149",body:'Hannan JML, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YHA. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells. Journal of Endocrinology. 2006;189:127-136'},{id:"B150",body:'WHO. Overview—Preventing chronic diseases: A vital investment. 2005'},{id:"B151",body:'Franz C, Baser KHC, Windisch W. Essential oils and aromatic plants in animal feeding—A European perspective. A review. Flavour and Fragrance Journal. 2010;25:327-340'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Debjoy Bhattacharjya",address:null,affiliation:'
Cytogenetics and Plant Breeding Section, Department of Sericulture, Raiganj University, India
Cytogenetics and Plant Breeding Section, Department of Sericulture, Raiganj University, India
Cytogenetics and Plant Biotechnology Research Unit, Department of Botany, University of Kalyani, India
'}],corrections:null},book:{id:"8077",type:"book",title:"Phytochemicals in Human Health",subtitle:null,fullTitle:"Phytochemicals in Human Health",slug:"phytochemicals-in-human-health",publishedDate:"February 12th 2020",bookSignature:"Venketeshwer Rao, Dennis Mans and Leticia Rao",coverURL:"https://cdn.intechopen.com/books/images_new/8077.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-588-3",printIsbn:"978-1-78985-587-6",pdfIsbn:"978-1-83968-413-5",isAvailableForWebshopOrdering:!0,editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"188886",title:"Prof.",name:"Črtomir",middleName:null,surname:"Rozman",email:"crt.rozman@um.si",fullName:"Črtomir Rozman",slug:"crtomir-rozman",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"2",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},booksEdited:[],chaptersAuthored:[{id:"52346",title:"Financial Feasibility Analysis of Natura Rab Business: Case Study",slug:"financial-feasibility-analysis-of-natura-rab-business-case-study",abstract:"In 2015 Natura Rab decided to provide three very important investments that will greatly change and facilitate its future business activities, especially the first project. The first and largest financial investment is the construction of the new organic shop with products at the central farm called Natura Rab. The second investment project is the new 2500 m2 olive plantation. The third investment in the analyzed family company is related to the beekeeping sector, and it involves several activities like buying new beekeeping equipment and new work vehicle. Before implementing the three investment projects, some financial parameters for the further assessment of investments were used, such as the net present value (NPV) and the internal rate of return (IRR). The investment value of the new shop is 38315.88 €, and the annual cash flow is 13,288 €. The net present value at the discount rate of 5.5% in the fourth year is 8260.55 €. The internal rate of return is 14.51%. The investment value for the second project, the new olive plantation, is 6620 €, and the annual cash flow is 2664.02 €. The net present value at the discount rate of 5.5% in the third year is 567.35 €. The internal rate of return is 10.04%. The investment value of the beekeeping sector for this year is 18428.50 €, and the annual cash flow is 41537.20 €. The net present value at the discount rate of 5.5% after the first year is 20943.25 €.",signatures:"Karmen Pažek, Matija Kaštelan, Martina Bavec, Črtomir Rozman\nand Jernej Prišenk",authors:[{id:"171257",title:"Prof.",name:"Martina",surname:"Bavec",fullName:"Martina Bavec",slug:"martina-bavec",email:"martina.bavec@um.si"},{id:"179642",title:"Prof.",name:"Karmen",surname:"Pažek",fullName:"Karmen Pažek",slug:"karmen-pazek",email:"karmen.pazek@um.si"},{id:"188470",title:"Dr.",name:"Jernej",surname:"Prisenk",fullName:"Jernej Prisenk",slug:"jernej-prisenk",email:"jernej.prisenk@um.si"},{id:"188886",title:"Prof.",name:"Črtomir",surname:"Rozman",fullName:"Črtomir Rozman",slug:"crtomir-rozman",email:"crt.rozman@um.si"},{id:"188887",title:"MSc.",name:"Matija",surname:"Kaštelan",fullName:"Matija Kaštelan",slug:"matija-kastelan",email:"matija.kastelan@student.um.si"}],book:{id:"5438",title:"Operations Research",slug:"operations-research-the-art-of-making-good-decisions",productType:{id:"1",title:"Edited Volume"}}},{id:"62821",title:"An Evaluation of Three Different Infield Navigation Algorithms",slug:"an-evaluation-of-three-different-infield-navigation-algorithms",abstract:"In this chapter, we present and evaluate three different infield navigation algorithms, based on the readings from a LIDAR sensor. All three algorithms are tested on a small field robot and used to autonomously drive the robot between the two adjacent rows of maze plants. The first algorithm is the simplest one and just takes distance readings from the left and right side. If robot is not in the center of the mid-row space, it adjusts its course by turning the robot in the right direction accordingly. The second approach groups the left and right readings into two vertical lines by using least-square fit approach. According to the calculated distance and orientation to both lines, it adjusts the course of the robot. The third approach tries to fit an optimal triangle between the robot and the plants, revealing the most optimal one. Based on its shape, the course of the robot is adjusted. All three algorithms are tested in a simulated (ROS stage) and then in an outdoor (maze test field) environment comparing the optimal line with the actual calculated position of the robot. The tests prove that all three approaches work with an error of 0.041 ± 0.034 m for the first algorithm, 0.07 ± 0.059 m for the second, and 0.078 ± 0.055 m error for the third.",signatures:"Peter Bernad, Peter Lepej, Črtomir Rozman, Karmen Pažek and Jurij Rakun",authors:[{id:"179642",title:"Prof.",name:"Karmen",surname:"Pažek",fullName:"Karmen Pažek",slug:"karmen-pazek",email:"karmen.pazek@um.si"},{id:"188886",title:"Prof.",name:"Črtomir",surname:"Rozman",fullName:"Črtomir Rozman",slug:"crtomir-rozman",email:"crt.rozman@um.si"},{id:"255090",title:"Dr.",name:"Jurij",surname:"Rakun",fullName:"Jurij Rakun",slug:"jurij-rakun",email:"jurij.rakun@um.si"},{id:"255091",title:"Dr.",name:"Peter",surname:"Lepej",fullName:"Peter Lepej",slug:"peter-lepej",email:"peter@vistion.si"},{id:"255092",title:"BSc.",name:"Peter",surname:"Bernard",fullName:"Peter Bernard",slug:"peter-bernard",email:"peterbernad@gmail.com"}],book:{id:"7270",title:"Agricultural Robots",slug:"agricultural-robots-fundamentals-and-applications",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"26862",title:"Prof.",name:"Susana",surname:"Azevedo",slug:"susana-azevedo",fullName:"Susana Azevedo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"140599",title:"Dr.",name:"Milos",surname:"Vasic",slug:"milos-vasic",fullName:"Milos Vasic",position:"fellow researcher",profilePictureURL:"https://mts.intechopen.com/storage/users/140599/images/4727_n.jpg",biography:null,institutionString:null,institution:null},{id:"171257",title:"Prof.",name:"Martina",surname:"Bavec",slug:"martina-bavec",fullName:"Martina Bavec",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},{id:"179642",title:"Prof.",name:"Karmen",surname:"Pažek",slug:"karmen-pazek",fullName:"Karmen Pažek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/179642/images/system/179642.jpg",biography:"Karmen Pažek was born in 1976. She graduated from the Faculty of Agriculture, University of Maribor, Slovenia, in 2000. In 2001 she was employed at the same faculty as an assistant for the field of grassland management. Between 2000 and 2003, she enrolled in the master\\'s study program in Agriculture Economics at the same faculty, and in 2003 she received her master\\'s degree. In the same year, she enrolled in a doctoral study in Agriculture Economics at the Faculty of Agriculture and obtained the status of a research assistant. In 2006 she successfully completed her Ph.D. in Agriculture Economics.\n\n\n\nSince 2006 she has been habilitated at the University of Maribor, and Life Sciences (she has been a full professor since 2016) for the field of Farm management. She holds several courses at all levels of study. She is currently the head of the 1st-degree study Agriculture Economics and Rural Development and the Vice Dean for Education.\n\n\n\nHer research includes the development of decision support tools and systems for farm management (simulation modeling, multicriteria decision analysis, option models, risk management), the economics of agricultural production, and other modern methods of operational research.",institutionString:"University of Maribor",institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},{id:"188470",title:"Dr.",name:"Jernej",surname:"Prisenk",slug:"jernej-prisenk",fullName:"Jernej Prisenk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},{id:"188887",title:"MSc.",name:"Matija",surname:"Kaštelan",slug:"matija-kastelan",fullName:"Matija Kaštelan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Maribor",institutionURL:null,country:{name:"Slovenia"}}},{id:"191338",title:"Dr.",name:"Wolfgang",surname:"Ossadnik",slug:"wolfgang-ossadnik",fullName:"Wolfgang Ossadnik",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Osnabrück University",institutionURL:null,country:{name:"Germany"}}},{id:"191697",title:"Dr.",name:"Zagorka",surname:"Radojevic",slug:"zagorka-radojevic",fullName:"Zagorka Radojevic",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"191698",title:"Dr.",name:"Robert",surname:"Rekecki",slug:"robert-rekecki",fullName:"Robert Rekecki",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"191718",title:"M.Sc.",name:"Fabian",surname:"Burrey",slug:"fabian-burrey",fullName:"Fabian Burrey",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Osnabrück University",institutionURL:null,country:{name:"Germany"}}}]},generic:{page:{slug:"OA-publishing-fees",title:"Open Access Publishing Fees",intro:"
The Open Access model is applied to all of our publications and is designed to eliminate subscriptions and pay-per-view fees. This approach ensures free, immediate access to full text versions of your research.
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
\\n\\n
The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
\\n\\n
OAPF Publishing Options
\\n\\n
\\n\\t
1,400 GBP Chapter - Edited Volume
\\n\\t
850 GBP Chapter - Book Series Topic (Annual Volume)
\\n\\t
10,000 GBP Monograph - Long Form
\\n\\t
4,000 GBP Compacts Monograph - Short Form
\\n\\t
850 GBP Journal Article (Across Portfolio)
\\n
\\n\\n
During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
\\n\\n
*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
\\n\\n
Services included are:
\\n\\n
\\n\\t
An online manuscript tracking system to facilitate your work
\\n\\t
Personal contact and support throughout the publishing process from your dedicated Author Service Manager
\\n\\t
Assurance that your manuscript meets the highest publishing standards
\\n\\t
English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
\\n\\t
XML Typesetting and pagination - web (PDF, HTML) and print files preparation
\\n\\t
Discoverability - electronic citation and linking via DOI
\\n\\t
Permanent and unrestricted online access to your work
\\n
\\n\\n
What isn't covered by the Open Access Publishing Fee?
\\n\\n
If your manuscript:
\\n\\n
\\n\\t
Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
\\n\\t
If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
\\n
\\n\\n
Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
\\n\\n
Open Access Funding
\\n\\n
To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\\n\\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
\\n\\n
Added Value of Publishing with IntechOpen
\\n\\n
Choosing to publish with IntechOpen ensures the following benefits:
\\n\\n
\\n\\t
Indexing and listing across major repositories, see details ...
\\n\\t
Long-term archiving
\\n\\t
Visibility on the world's strongest OA platform
\\n\\t
Live Performance Metrics to track readership and the impact of your chapter
\\n\\t
Dissemination and Promotion
\\n
\\n\\n
Benefits of Publishing with IntechOpen
\\n\\n
\\n\\t
Proven world leader in Open Access book publishing with over 10 years experience
\\n\\t
+5,700 OA books published
\\n\\t
Most competitive prices in the market
\\n\\t
Fully compliant with OA funding requirements
\\n\\t
Optimized processes that assure your research is made available to the scientific community without delay
\\n\\t
Personal support during every step of the publication process
\\n\\t
+184,650 citations in Web of Science databases
\\n\\t
Currently strongest OA platform with over 175 million downloads
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
\n\n
The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
\n\n
OAPF Publishing Options
\n\n
\n\t
1,400 GBP Chapter - Edited Volume
\n\t
850 GBP Chapter - Book Series Topic (Annual Volume)
\n\t
10,000 GBP Monograph - Long Form
\n\t
4,000 GBP Compacts Monograph - Short Form
\n\t
850 GBP Journal Article (Across Portfolio)
\n
\n\n
During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
\n\n
*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
\n\n
Services included are:
\n\n
\n\t
An online manuscript tracking system to facilitate your work
\n\t
Personal contact and support throughout the publishing process from your dedicated Author Service Manager
\n\t
Assurance that your manuscript meets the highest publishing standards
\n\t
English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
\n\t
XML Typesetting and pagination - web (PDF, HTML) and print files preparation
\n\t
Discoverability - electronic citation and linking via DOI
\n\t
Permanent and unrestricted online access to your work
\n
\n\n
What isn't covered by the Open Access Publishing Fee?
\n\n
If your manuscript:
\n\n
\n\t
Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
\n\t
If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
\n
\n\n
Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
\n\n
Open Access Funding
\n\n
To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\n\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
\n\n
Added Value of Publishing with IntechOpen
\n\n
Choosing to publish with IntechOpen ensures the following benefits:
\n\n
\n\t
Indexing and listing across major repositories, see details ...
\n\t
Long-term archiving
\n\t
Visibility on the world's strongest OA platform
\n\t
Live Performance Metrics to track readership and the impact of your chapter
\n\t
Dissemination and Promotion
\n
\n\n
Benefits of Publishing with IntechOpen
\n\n
\n\t
Proven world leader in Open Access book publishing with over 10 years experience
\n\t
+5,700 OA books published
\n\t
Most competitive prices in the market
\n\t
Fully compliant with OA funding requirements
\n\t
Optimized processes that assure your research is made available to the scientific community without delay
\n\t
Personal support during every step of the publication process
\n\t
+184,650 citations in Web of Science databases
\n\t
Currently strongest OA platform with over 175 million downloads
\n
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{mdrv:"www.intechopen.com"},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11660},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33642}],offset:12,limit:12,total:135275},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{},books:[{type:"book",id:"9985",title:"Geostatistics",subtitle:null,isOpenForSubmission:!0,hash:"423cb3896195a618c4acb493ce4fd23d",slug:null,bookSignature:"Prof. Jeffrey M. Yarus, Dr. Marko Maucec, Dr. Timothy C. Coburn and Associate Prof. Michael Pyrcz",coverURL:"https://cdn.intechopen.com/books/images_new/9985.jpg",editedByType:null,editors:[{id:"78011",title:"Prof.",name:"Jeffrey M.",surname:"Yarus",slug:"jeffrey-m.-yarus",fullName:"Jeffrey M. Yarus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11027",title:"Basics of Hypoglycemia",subtitle:null,isOpenForSubmission:!0,hash:"98ebc1e36d02be82c204b8fd5d24f97a",slug:null,bookSignature:"Dr. Alok Raghav",coverURL:"https://cdn.intechopen.com/books/images_new/11027.jpg",editedByType:null,editors:[{id:"334465",title:"Dr.",name:"Alok",surname:"Raghav",slug:"alok-raghav",fullName:"Alok Raghav"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11124",title:"Next-Generation Textiles",subtitle:null,isOpenForSubmission:!0,hash:"093f9e26bb829b8d414d13626aea1086",slug:null,bookSignature:"Dr. Hassan Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/11124.jpg",editedByType:null,editors:[{id:"90645",title:"Dr.",name:"Hassan",surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11369",title:"RNA Viruses Infection",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11433",title:"Human Migration in the Last Three Centuries",subtitle:null,isOpenForSubmission:!0,hash:"9836df9e82aa9f82e3852a60204909a8",slug:null,bookSignature:"Dr. Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/11433.jpg",editedByType:null,editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11438",title:"Fake News in the Era of Global Crises",subtitle:null,isOpenForSubmission:!0,hash:"5f61f975031e13ee705d8b5853f1aa58",slug:null,bookSignature:"Dr. David Eller",coverURL:"https://cdn.intechopen.com/books/images_new/11438.jpg",editedByType:null,editors:[{id:"476616",title:"Dr.",name:"Jack",surname:"Eller",slug:"jack-eller",fullName:"Jack Eller"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",subtitle:null,isOpenForSubmission:!0,hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",slug:null,bookSignature:"Dr. Marco Antonio Aceves Fernandez",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",editedByType:null,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11452",title:"Cryopreservation - Applications and Challenges",subtitle:null,isOpenForSubmission:!0,hash:"a6c3fd4384ff7deeab32fc82722c60e0",slug:null,bookSignature:"Dr. Marian Quain",coverURL:"https://cdn.intechopen.com/books/images_new/11452.jpg",editedByType:null,editors:[{id:"300385",title:"Dr.",name:"Marian",surname:"Quain",slug:"marian-quain",fullName:"Marian Quain"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11453",title:"Biomimetics - Bridging the Gap",subtitle:null,isOpenForSubmission:!0,hash:"173e62fa4d7bf5508cec3bdd8e3cb32d",slug:null,bookSignature:"Prof. Ziyad S. Haidar",coverURL:"https://cdn.intechopen.com/books/images_new/11453.jpg",editedByType:null,editors:[{id:"222709",title:"Prof.",name:"Ziyad S.",surname:"Haidar",slug:"ziyad-s.-haidar",fullName:"Ziyad S. Haidar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11456",title:"Autonomous Mobile Mapping Robots",subtitle:null,isOpenForSubmission:!0,hash:"405e1f7c0ef62700f4d590722cf428be",slug:null,bookSignature:"Dr. Janusz Bȩdkowski",coverURL:"https://cdn.intechopen.com/books/images_new/11456.jpg",editedByType:null,editors:[{id:"63695",title:"Dr.",name:"Janusz",surname:"Bȩdkowski",slug:"janusz-bdkowski",fullName:"Janusz Bȩdkowski"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11459",title:"Soft Robotics - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"06e947238d5d4ea1162509a5d66de887",slug:null,bookSignature:"Dr. Mahmut Reyhanoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11459.jpg",editedByType:null,editors:[{id:"15068",title:"Dr.",name:"Mahmut",surname:"Reyhanoglu",slug:"mahmut-reyhanoglu",fullName:"Mahmut Reyhanoglu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:27},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:7},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:16},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:42},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:17},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:68},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:3},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:6},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:7},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:494},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3737",title:"MATLAB",subtitle:"Modelling, Programming and Simulations",isOpenForSubmission:!1,hash:null,slug:"matlab-modelling-programming-and-simulations",bookSignature:"Emilson Pereira Leite",coverURL:"https://cdn.intechopen.com/books/images_new/3737.jpg",editors:[{id:"12051",title:"Prof.",name:"Emilson",middleName:null,surname:"Pereira Leite",slug:"emilson-pereira-leite",fullName:"Emilson Pereira Leite"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"1770",title:"Gel Electrophoresis",subtitle:"Principles and Basics",isOpenForSubmission:!1,hash:"279701f6c802cf02deef45103e0611ff",slug:"gel-electrophoresis-principles-and-basics",bookSignature:"Sameh Magdeldin",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4798},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7175,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1981,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2308,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1473,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318571,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271836,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",publishedDate:"July 1st 2013",numberOfDownloads:243450,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1582,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2082,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",publishedDate:"October 17th 2012",numberOfDownloads:256294,editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"119",title:"Industrial Engineering and Management",slug:"industrial-engineering-and-management",parent:{id:"11",title:"Engineering",slug:"engineering"},numberOfBooks:50,numberOfSeries:0,numberOfAuthorsAndEditors:1144,numberOfWosCitations:1464,numberOfCrossrefCitations:1058,numberOfDimensionsCitations:2263,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"119",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10385",title:"Advanced Applications of Hydrogen and Engineering Systems in the Automotive Industry",subtitle:null,isOpenForSubmission:!1,hash:"362b356f3ae4c3b5ab5a5fe69d92d270",slug:"advanced-applications-of-hydrogen-and-engineering-systems-in-the-automotive-industry",bookSignature:"Luigi Cocco and Muhammad Aziz",coverURL:"https://cdn.intechopen.com/books/images_new/10385.jpg",editedByType:"Edited by",editors:[{id:"112023",title:"Dr.",name:"Luigi",middleName:null,surname:"Cocco",slug:"luigi-cocco",fullName:"Luigi Cocco"}],equalEditorOne:{id:"98160",title:"Associate Prof.",name:"Muhammad",middleName:null,surname:"Aziz",slug:"muhammad-aziz",fullName:"Muhammad Aziz",profilePictureURL:"https://mts.intechopen.com/storage/users/98160/images/system/98160.jpg",biography:"Dr. Muhammad Aziz is currently an Associate Professor at the Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. He received a BEng, MEng, and DEng in Mechanical Engineering from Kyushu University, Japan, in 2004, 2006, and 2008, respectively. His research interests include power generation, renewable energy utilization, process modeling, smart grids, electric vehicles, batteries, and hydrogen production and utilization. He has published more than 125 peer-reviewed journals, 22 books and book chapters, and more than 200 proceedings. In addition, Dr. Aziz is also an active reviewer for more than sixty distinguished journals related to energy research.",institutionString:"The University of Tokyo",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Tokyo",institutionURL:null,country:{name:"Japan"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9925",title:"Quality Control",subtitle:"Intelligent Manufacturing, Robust Design and Charts",isOpenForSubmission:!1,hash:"865332c5f031b481c1359793edc79fe5",slug:"quality-control-intelligent-manufacturing-robust-design-and-charts",bookSignature:"Pengzhong Li, Paulo António Rodrigues Pereira and Helena Navas",coverURL:"https://cdn.intechopen.com/books/images_new/9925.jpg",editedByType:"Edited by",editors:[{id:"19636",title:"Prof.",name:"Pengzhong",middleName:null,surname:"Li",slug:"pengzhong-li",fullName:"Pengzhong Li"}],equalEditorOne:{id:"178637",title:"Dr.",name:"Paulo",middleName:null,surname:"Pereira",slug:"paulo-pereira",fullName:"Paulo Pereira",profilePictureURL:"https://mts.intechopen.com/storage/users/178637/images/system/178637.jpeg",biography:"Dr. Pereira received his Ph.D. in Biotechnology from the Catholic University of Portugal. He has been recruited as a quality and laboratory expert for seminars and professional laboratory meetings throughout Europe, Africa, and South America. He has more than twenty-five years of experience working in medical laboratories, having held key scientific leadership roles: 15+ years as a senior researcher; 10+ years as a consultant for a metrology laboratory based on ISO/IEC 17025 specifications and related standards; 20+ years as a consultant and auditor of quality management systems based on ISO 9001, ISO/IEC 17025, and ISO 15189 standards; 16+ years as the quality manager in the Portuguese Institute of Blood and Transplantation, including more than 6 years in national coordination; and 6+ years as a professor of Quality Assurance. Currently, he is the head of the R&D Department at the Portuguese Institute of Blood and Transplantation, Lisbon, Portugal. Dr. Pereira is the author of several peer-reviewed scientific articles and indexed books and chapters. He is an editor for several books. He serves as a member of several editorial boards. He is a member of the Clinical Laboratory and Standards Institute and Eurachem. Dr. Pereira is an expert on in vitro diagnostic medical devices at the European Commission / European Medicines Agency.",institutionString:"Portuguese Institute of Blood and Transplantation",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:null},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9888",title:"Nuclear Power Plants",subtitle:"The Processes from the Cradle to the Grave",isOpenForSubmission:!1,hash:"c2c8773e586f62155ab8221ebb72a849",slug:"nuclear-power-plants-the-processes-from-the-cradle-to-the-grave",bookSignature:"Nasser Awwad",coverURL:"https://cdn.intechopen.com/books/images_new/9888.jpg",editedByType:"Edited by",editors:[{id:"145209",title:"Prof.",name:"Nasser",middleName:"S",surname:"Awwad",slug:"nasser-awwad",fullName:"Nasser Awwad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9423",title:"AI and Learning Systems",subtitle:"Industrial Applications and Future Directions",isOpenForSubmission:!1,hash:"10ac8fb0bdbf61044395963028653d21",slug:"ai-and-learning-systems-industrial-applications-and-future-directions",bookSignature:"Konstantinos Kyprianidis and Erik Dahlquist",coverURL:"https://cdn.intechopen.com/books/images_new/9423.jpg",editedByType:"Edited by",editors:[{id:"35868",title:"Prof.",name:"Konstantinos",middleName:"G.",surname:"Kyprianidis",slug:"konstantinos-kyprianidis",fullName:"Konstantinos Kyprianidis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9279",title:"Concepts, Applications and Emerging Opportunities in Industrial Engineering",subtitle:null,isOpenForSubmission:!1,hash:"9bfa87f9b627a5468b7c1e30b0eea07a",slug:"concepts-applications-and-emerging-opportunities-in-industrial-engineering",bookSignature:"Gary Moynihan",coverURL:"https://cdn.intechopen.com/books/images_new/9279.jpg",editedByType:"Edited by",editors:[{id:"16974",title:"Dr.",name:"Gary",middleName:null,surname:"Moynihan",slug:"gary-moynihan",fullName:"Gary Moynihan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9174",title:"Product Design",subtitle:null,isOpenForSubmission:!1,hash:"3510bacbbf4d365e97510bf962652de1",slug:"product-design",bookSignature:"Cătălin Alexandru, Codruta Jaliu and Mihai Comşit",coverURL:"https://cdn.intechopen.com/books/images_new/9174.jpg",editedByType:"Edited by",editors:[{id:"2767",title:"Prof.",name:"Catalin",middleName:null,surname:"Alexandru",slug:"catalin-alexandru",fullName:"Catalin Alexandru"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8623",title:"Maintenance Management",subtitle:null,isOpenForSubmission:!1,hash:"91cc93ad76fdd6709b8c50c6ba7e4e0c",slug:"maintenance-management",bookSignature:"Fausto Pedro García Márquez and Mayorkinos Papaelias",coverURL:"https://cdn.intechopen.com/books/images_new/8623.jpg",editedByType:"Edited by",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7441",title:"Micromachining",subtitle:null,isOpenForSubmission:!1,hash:"2084b93f70df82e634ec776962e871fd",slug:"micromachining",bookSignature:"Zdravko Stanimirović and Ivanka Stanimirović",coverURL:"https://cdn.intechopen.com/books/images_new/7441.jpg",editedByType:"Edited by",editors:[{id:"3421",title:"Dr.",name:"Zdravko",middleName:null,surname:"Stanimirović",slug:"zdravko-stanimirovic",fullName:"Zdravko Stanimirović"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7454",title:"Industrial Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7008bbdc804192f8969a34deda417b05",slug:"industrial-engineering",bookSignature:"Ainul Akmar Mokhtar and Masdi Muhammad",coverURL:"https://cdn.intechopen.com/books/images_new/7454.jpg",editedByType:"Edited by",editors:[{id:"219461",title:"Associate Prof.",name:"Ainul Akmar",middleName:null,surname:"Mokhtar",slug:"ainul-akmar-mokhtar",fullName:"Ainul Akmar Mokhtar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7436",title:"New Trends in Industrial Automation",subtitle:null,isOpenForSubmission:!1,hash:"a6abb5722b5e27eb4b886a74f5aa4333",slug:"new-trends-in-industrial-automation",bookSignature:"Pengzhong Li",coverURL:"https://cdn.intechopen.com/books/images_new/7436.jpg",editedByType:"Edited by",editors:[{id:"19636",title:"Prof.",name:"Pengzhong",middleName:null,surname:"Li",slug:"pengzhong-li",fullName:"Pengzhong Li"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6838",title:"Power Plants in the Industry",subtitle:null,isOpenForSubmission:!1,hash:"5e647d27dab23e014dd8881ac3d5931c",slug:"power-plants-in-the-industry",bookSignature:"Tolga Taner",coverURL:"https://cdn.intechopen.com/books/images_new/6838.jpg",editedByType:"Edited by",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6332",title:"Thermal Power Plants",subtitle:"New Trends and Recent Developments",isOpenForSubmission:!1,hash:"616ffd286d75ca988abf59b408880a98",slug:"thermal-power-plants-new-trends-and-recent-developments",bookSignature:"Pawe? Madejski",coverURL:"https://cdn.intechopen.com/books/images_new/6332.jpg",editedByType:"Edited by",editors:[{id:"179645",title:"Dr.",name:"Paweł",middleName:null,surname:"Madejski",slug:"pawel-madejski",fullName:"Paweł Madejski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:50,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"15530",doi:"10.5772/14592",title:"Integrating Lean, Agile, Resilience and Green Paradigms in Supply Chain Management (LARG_SCM)",slug:"integrating-lean-agile-resilience-and-green-paradigms-in-supply-chain-management-larg-scm-",totalDownloads:5646,totalCrossrefCites:27,totalDimensionsCites:59,abstract:null,book:{id:"106",slug:"supply-chain-management",title:"Supply Chain Management",fullTitle:"Supply Chain Management"},signatures:"Helena Carvalho and V. Cruz-Machado",authors:[{id:"18263",title:"Prof.",name:"Helena",middleName:null,surname:"Carvalho",slug:"helena-carvalho",fullName:"Helena Carvalho"},{id:"22440",title:"Prof.",name:"Virgílio",middleName:null,surname:"Cruz Machado",slug:"virgilio-cruz-machado",fullName:"Virgílio Cruz Machado"}]},{id:"34441",doi:"10.5772/35205",title:"Condition Monitoring of Railway Track Using In-Service Vehicle",slug:"condition-monitoring-of-railway-track-using-in-service-vehicle",totalDownloads:5010,totalCrossrefCites:24,totalDimensionsCites:47,abstract:null,book:{id:"2271",slug:"reliability-and-safety-in-railway",title:"Reliability and Safety in Railway",fullTitle:"Reliability and Safety in Railway"},signatures:"Hitoshi Tsunashima, Yasukuni Naganuma, Akira Matsumoto, Takeshi Mizuma and Hirotaka Mori",authors:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima"},{id:"113419",title:"Prof.",name:"Akira",middleName:null,surname:"Matsumoto",slug:"akira-matsumoto",fullName:"Akira Matsumoto"},{id:"113420",title:"Dr.",name:"Takeshi",middleName:null,surname:"Mizuma",slug:"takeshi-mizuma",fullName:"Takeshi Mizuma"},{id:"113422",title:"Mr.",name:"Hirotaka",middleName:null,surname:"Mori",slug:"hirotaka-mori",fullName:"Hirotaka Mori"},{id:"113423",title:"MSc.",name:"Yasukuni",middleName:null,surname:"Naganuma",slug:"yasukuni-naganuma",fullName:"Yasukuni Naganuma"}]},{id:"15535",doi:"10.5772/15006",title:"Supply Chain Resilience Using the Mapping Approach",slug:"supply-chain-resilience-using-the-mapping-approach",totalDownloads:4994,totalCrossrefCites:16,totalDimensionsCites:42,abstract:null,book:{id:"106",slug:"supply-chain-management",title:"Supply Chain Management",fullTitle:"Supply Chain Management"},signatures:"A.P. Barroso, V.H. Machado and V. Cruz Machado",authors:[{id:"22440",title:"Prof.",name:"Virgílio",middleName:null,surname:"Cruz Machado",slug:"virgilio-cruz-machado",fullName:"Virgílio Cruz Machado"},{id:"19465",title:"Prof.",name:"Ana Paula",middleName:null,surname:"Barroso",slug:"ana-paula-barroso",fullName:"Ana Paula Barroso"},{id:"22439",title:"Prof.",name:"Virgínia Helena",middleName:null,surname:"Machado",slug:"virginia-helena-machado",fullName:"Virgínia Helena Machado"}]},{id:"41903",doi:"10.5772/55065",title:"An Overview of Human Reliability Analysis Techniques in Manufacturing Operations",slug:"an-overview-of-human-reliability-analysis-techniques-in-manufacturing-operations",totalDownloads:5019,totalCrossrefCites:10,totalDimensionsCites:40,abstract:null,book:{id:"3216",slug:"operations-management",title:"Operations Management",fullTitle:"Operations Management"},signatures:"Valentina Di Pasquale, Raffaele Iannone, Salvatore Miranda and Stefano Riemma",authors:[{id:"162902",title:"Prof.",name:"Raffaele",middleName:null,surname:"Iannone",slug:"raffaele-iannone",fullName:"Raffaele Iannone"},{id:"163160",title:"Prof.",name:"Salvatore",middleName:null,surname:"Miranda",slug:"salvatore-miranda",fullName:"Salvatore Miranda"},{id:"163161",title:"Prof.",name:"Stefano",middleName:null,surname:"Riemma",slug:"stefano-riemma",fullName:"Stefano Riemma"},{id:"163162",title:"Ms.",name:"Valentina",middleName:null,surname:"Di Pasquale",slug:"valentina-di-pasquale",fullName:"Valentina Di Pasquale"}]},{id:"17872",doi:"10.5772/19997",title:"Building Blocks of the Internet of Things: State of the Art and Beyond",slug:"building-blocks-of-the-internet-of-things-state-of-the-art-and-beyond",totalDownloads:5491,totalCrossrefCites:28,totalDimensionsCites:40,abstract:null,book:{id:"446",slug:"deploying-rfid-challenges-solutions-and-open-issues",title:"Deploying RFID",fullTitle:"Deploying RFID - Challenges, Solutions, and Open Issues"},signatures:"Alexandru Serbanati, Carlo Maria Medaglia and Ugo Biader Ceipidor",authors:[{id:"37101",title:"Prof.",name:"Carlo Maria",middleName:null,surname:"Medaglia",slug:"carlo-maria-medaglia",fullName:"Carlo Maria Medaglia"},{id:"38529",title:"Prof.",name:"Ugo",middleName:null,surname:"Biader Ceipidor",slug:"ugo-biader-ceipidor",fullName:"Ugo Biader Ceipidor"},{id:"38530",title:"Mr.",name:"Alexandru",middleName:null,surname:"Serbanati",slug:"alexandru-serbanati",fullName:"Alexandru Serbanati"}]}],mostDownloadedChaptersLast30Days:[{id:"23741",title:"Quality Assurance and Quality Control of Equipment in Diagnostic Radiology Practice-The Ghanaian Experience",slug:"quality-assurance-and-quality-control-of-equipment-in-diagnostic-radiology-practice-the-ghanaian-exp",totalDownloads:18889,totalCrossrefCites:3,totalDimensionsCites:6,abstract:null,book:{id:"632",slug:"wide-spectra-of-quality-control",title:"Wide Spectra of Quality Control",fullTitle:"Wide Spectra of Quality Control"},signatures:"Stephen Inkoom, Cyril Schandorf, Geoffrey Emi-Reynolds and John Justice Fletcher",authors:[{id:"48333",title:"Mr",name:"Stephen",middleName:null,surname:"Inkoom",slug:"stephen-inkoom",fullName:"Stephen Inkoom"},{id:"55912",title:"Prof.",name:"Cyril",middleName:null,surname:"Schandorf",slug:"cyril-schandorf",fullName:"Cyril Schandorf"},{id:"55913",title:"Prof.",name:"Geoffrey",middleName:null,surname:"Emi-Reynolds",slug:"geoffrey-emi-reynolds",fullName:"Geoffrey Emi-Reynolds"},{id:"55914",title:"Prof.",name:"John",middleName:null,surname:"Fletcher",slug:"john-fletcher",fullName:"John Fletcher"}]},{id:"23728",title:"Good Clinical Laboratory Practice (GCLP) for Molecular Based Tests Used in Diagnostic Laboratories",slug:"good-clinical-laboratory-practice-gclp-for-molecular-based-tests-used-in-diagnostic-laboratories",totalDownloads:15471,totalCrossrefCites:1,totalDimensionsCites:8,abstract:null,book:{id:"632",slug:"wide-spectra-of-quality-control",title:"Wide Spectra of Quality Control",fullTitle:"Wide Spectra of Quality Control"},signatures:"Raquel V. Viana and Carole L. Wallis",authors:[{id:"54659",title:"Dr.",name:"Carole",middleName:null,surname:"Wallis",slug:"carole-wallis",fullName:"Carole Wallis"},{id:"60112",title:"Ms",name:"Raquel",middleName:null,surname:"Viana",slug:"raquel-viana",fullName:"Raquel Viana"}]},{id:"65764",title:"Supplier Evaluation and Selection in Automobile Industry",slug:"supplier-evaluation-and-selection-in-automobile-industry",totalDownloads:1841,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In automobile industry, to operate effectively the supply chain management, the purchasing function is very important to perform effectively. It is the responsibility of purchasing department to choose the correct suppliers to purchase the required products for their company. Thus, supplier evaluation technique is essential for purchase manager’s point of view to choose the best supplier among available suppliers. The literature addresses quality, delivery, technology, value and service as the five most common criteria used for supplier quality evaluation. In this chapter, approach of evaluation and selection of supplier has been presented as per the ISO 9000/TS16949 standards. Considering the most important criteria for evaluating the quality of suppliers based on a review of the literature and observation in practice. Finally, these organizations continuously review and implement effective quality systems following the rigorous ISO 9000/TS16949 series of standards and most automobile companies have developed in-house procedures and software for the supplier selection process.",book:{id:"7454",slug:"industrial-engineering",title:"Industrial Engineering",fullTitle:"Industrial Engineering"},signatures:"Lokpriya Gaikwad and Vivek Sunnapwar",authors:[{id:"246830",title:"Prof.",name:"Lokpriya Mohanrao",middleName:null,surname:"Gaikwad",slug:"lokpriya-mohanrao-gaikwad",fullName:"Lokpriya Mohanrao Gaikwad"},{id:"251857",title:"Dr.",name:"Vivek K.",middleName:null,surname:"Sunnapwar",slug:"vivek-k.-sunnapwar",fullName:"Vivek K. Sunnapwar"}]},{id:"43383",title:"Improving Operations Performance with World Class Manufacturing Technique: A Case in Automotive Industry",slug:"improving-operations-performance-with-world-class-manufacturing-technique-a-case-in-automotive-indus",totalDownloads:26585,totalCrossrefCites:11,totalDimensionsCites:23,abstract:null,book:{id:"3216",slug:"operations-management",title:"Operations Management",fullTitle:"Operations Management"},signatures:"Fabio De Felice, Antonella Petrillo and Stanislao Monfreda",authors:[{id:"161682",title:"Prof.",name:"Fabio",middleName:null,surname:"De Felice",slug:"fabio-de-felice",fullName:"Fabio De Felice"},{id:"167280",title:"Dr.",name:"Stanislao",middleName:null,surname:"Monfreda",slug:"stanislao-monfreda",fullName:"Stanislao Monfreda"},{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"}]},{id:"63005",title:"Industry 3.0 to Industry 4.0: Exploring the Transition",slug:"industry-3-0-to-industry-4-0-exploring-the-transition",totalDownloads:1803,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This work is a How-To-Guide for DigitALIZAtion of Industry 4.0 Manufacturing. It provides a novel ALIZA Canvas and ALIZA Process supported by a comprehensive ALIZA Toolset. This output is derived from observed, tangible deficiencies in contemporary functional communications in manufacturing. This study proposes an innovative approach with robust methodologies for strategic alignment of the technical and business components in manufacturing. The requirement for a supplementary educational infrastructure, to address the pronounced educational shortcomings and knowledge gaps in the transition to Industry 4.0 is outlined. An explanation is provided of how E-Cubers (our own educational organization) will design, develop, and deliver educational programmes on Topics relevant to achieving Industry 4.0 Equipment Engineering Excellence. It defines and tests the novel concept of the E-Cubers Eight Ps; encompassing prioritized problem solving, via portfolios and projects, through peer collaboration within a defined technology playground with emphasis on learning and playing with passion. The E-Cubers Eight Ps is combined with The E-Cubers Library to deliver a truly comprehensive specialist, national learning framework. This holistic approach will ultimately enable Ireland to lead the way in Industry 4.0 by doing what we do best “ag spraoi agus ag imirt” (Gaelic – playing by having fun and competing).",book:{id:"7436",slug:"new-trends-in-industrial-automation",title:"New Trends in Industrial Automation",fullTitle:"New Trends in Industrial Automation"},signatures:"Shane Loughlin",authors:null}],onlineFirstChaptersFilter:{topicId:"119",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"1082338",title:"Capacitated Clustering Models to Real Life Applications",slug:null,totalDownloads:1,totalDimensionsCites:0,doi:"10.5992/intechopen.1000213",abstract:'
This chapter considers the use of different capacitated clustering problems and models that fits better in real-life applications such as household waste collection, IT teams layout in software factories, wholesales distribution, and staff’s home collection or delivery to/from workplace. Each application is explored in its regular form as it is being developed by contractors and/or users. We consider for each application the aspects of solving the problem by the appropriate mathematical programming model and decision support methodology (using aggregated Geographical Information System and mobile technology) to hold correctly and most precisely the problems and difficulties related to instances in evaluation. The experience on these fields is here revealed in detailed form as the results obtained by using the techniques here explained.
',book:{id:"11082",title:"Operations Management",coverURL:"https://cdn.intechopen.com/books/images_new/11082.jpg"},signatures:"Marcos J. Negreiros, Nelson Maculan, Augusto W.C. Palhano, Albert E.F. Muritiba and Pablo L.F. Batista"},{id:"81676",title:"Multiscale Modeling Framework for Defect Generation in Metal Powder Bed Fusion Process to Correlate Process Parameters and Structural Properties",slug:"multiscale-modeling-framework-for-defect-generation-in-metal-powder-bed-fusion-process-to-correlate-",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.104493",abstract:"Powder Bed Fusion (PBF) is one of the most popular additive manufacturing methods employed extensively to fabricate complex parts especially in industries with stringent standard criteria, including aerospace, medical, and defense. DMLS/PBF fabrication of parts that is free of defects represents major challenges. A comprehensive study of thermal defects, contributing parameters, and their correlation is necessary to better understand how process specifications initiate these defects. Monitoring & controlling temperature and its distribution throughout a layer under fabrication is an effective and efficient proxy to controlling process thermal evolution, which is a completely experimental technique. This being highly costly specifically for metal printing, computer-based numerical simulation can significantly help the identification of temperature distribution during the printing process. In this paper, a multiscale modeling technique is demonstrated with commercially available software tools to correlate the defect generation in metal PBF process and significant process parameters. This technique can help efficiently design the process setting in addition to or even absence of experimental monitoring data. This research work is a part of a larger project of closed-loop control strategy development using physics-based modeling and graph-based artificial neural network implementation for reducing thermally induced part defects in metal 3D printed process.",book:{id:"11171",title:"Trends and Opportunities of Rapid Prototyping Technologies",coverURL:"https://cdn.intechopen.com/books/images_new/11171.jpg"},signatures:"Suchana Akter Jahan and Hazim El-Mounayri"},{id:"1089787",title:"Differences between Universal-Deterministic and Probabilistic Hypotheses in Operations Management Research",slug:null,totalDownloads:4,totalDimensionsCites:0,doi:"10.5992/intechopen.1000218",abstract:'
Very few papers in the operations management (OM) field have taken the themes of universal-deterministic (UD) and probabilistic hypotheses as their main topics of investigation and discussion. Our investigation continues a recent line of research that focuses on a better understanding of these critical issues. Specifically, we attempt to respond to some pointed criticisms that experts in the field have made when the topic UD and probabilistic hypotheses have emerged in academic settings/discussions. A detailed analysis of those criticisms shows that they lack merit, thereby reinforcing our argument that it is most important to distinguish between the two types of scientific hypotheses in order to advance in the rigor of OM theoretical and empirical research. Ideas for future research are outlined.
',book:{id:"11082",title:"Operations Management",coverURL:"https://cdn.intechopen.com/books/images_new/11082.jpg"},signatures:"Roberto Sarmiento"},{id:"1083885",title:"Design and Planning Robust and Competitive Supply Chains",slug:null,totalDownloads:5,totalDimensionsCites:0,doi:"10.5992/intechopen.1000208",abstract:'
In recent years, supply chains in the manufacturing industry have become more and more complicated, and many cases of supply chain disruptions due to natural disasters have been confirmed. It is necessary for manufacturers to build a system that can help them alleviate losses and shorten recovery periods due to supply chain disruptions. Supplier diversification, as well as supplier evaluation and selection, are discussed as risk aversion measures in many papers. However, even if the procurement source has been evaluated enough, there are problems, such as opportunity loss during recovery periods and soaring procurement costs during normal periods. In this chapter, to help Japanese manufacturers to alleviate opportunity loss under component procurement disruption situations and keep cost competitiveness in normal periods, decision-making models of supply chain structure assessment, supplier selection, procurement allocation, and trading contracts are designed and verified.
',book:{id:"11082",title:"Operations Management",coverURL:"https://cdn.intechopen.com/books/images_new/11082.jpg"},signatures:"Kotomichi Matsuno, Jiahua Weng, Noriyuki Hosokawa and Takahiro Ohno"},{id:"1085055",title:"Performance Measurement Using Deterministic and Stochastic Multiplicative Directional Distance Functions",slug:null,totalDownloads:5,totalDimensionsCites:0,doi:"10.5992/intechopen.1000179",abstract:'
Performance measurement is essential for fostering continuous improvement of the production and operation management in a firm or organization. We consider a deterministic scenario based on a flexible structure of production technology and establish a multiplicative relationship between the generalized multiplicative directional distance function (GMDDF) and geometric distance function (GDF). We also introduce a stochastic multiplicative directional distance function (SMDDF). Based on a stochastic scenario, the SMDDF can be estimated by the method of convex nonparametric least squares. As an illustrative application, we investigate the productive performance of Japanese life insurance companies using a panel dataset spanning 2016 to 2020.
',book:{id:"11082",title:"Operations Management",coverURL:"https://cdn.intechopen.com/books/images_new/11082.jpg"},signatures:"Yu Zhao"},{id:"1085559",title:"Assessment of Medical Equipment Maintenance Management",slug:null,totalDownloads:20,totalDimensionsCites:0,doi:"10.5992/intechopen.1000210",abstract:'
Today's modern hospital is highly dependent on different types of medical equipment to help diagnose, monitor, and treat patients. Medical equipment maintenance is important to reduce costs, reduce patient dissatisfaction, treat the patient in a timely manner, and reduce mortality and risks during patient care. Good maintenance management is important to have well-planned and implemented programs through which hospitals can minimize medical device failures or other problems with the operation of medical equipment. Medical equipment plays an important role in the hospital system; therefore, the acquisition, maintenance, and replacement of medical equipment are key factors in hospitals for the implementation of the health service. Thus, in order to ensure the quality of medical devices for the provision of medical care, it is imperative to evaluate the safety of using hospital maintenance management. In order to achieve these goals, hospitals must develop checklists that identify the state of performance of medical equipment maintenance. It is essential for clinical managers and engineers not only to increase the capacity of the hospital but also to predict the risks of sudden failure. Given the lack of unique and comprehensive maintenance management checklists, the current goal is to design and develop medical equipment maintenance management checklists.
',book:{id:"11082",title:"Operations Management",coverURL:"https://cdn.intechopen.com/books/images_new/11082.jpg"},signatures:"Călin Corciovă, Robert Fuior, Doru Andriţoi and Cătălina Luca"}],onlineFirstChaptersTotal:10},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. Barderas",slug:"oxidative-stress-in-cardiovascular-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 22nd 2022",isOpenForSubmission:!0,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. Barderas",slug:"oxidative-stress-in-cardiovascular-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"82751",title:"Mitochondria-Endoplasmic Reticulum Interaction in Central Neurons",doi:"10.5772/intechopen.105738",signatures:"Liliya Kushnireva and Eduard Korkotian",slug:"mitochondria-endoplasmic-reticulum-interaction-in-central-neurons",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82709",title:"Fatty Acid Metabolism as a Tumor Marker",doi:"10.5772/intechopen.106072",signatures:"Gatot Nyarumenteng Adhipurnawan Winarno",slug:"fatty-acid-metabolism-as-a-tumor-marker",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82716",title:"Advanced glycation end product induced endothelial dysfunction through ER stress: Unravelling the role of Paraoxonase 2",doi:"10.5772/intechopen.106018",signatures:"Ramya Ravi and Bharathidevi Subramaniam Rajesh",slug:"advanced-glycation-end-product-induced-endothelial-dysfunction-through-er-stress-unravelling-the-rol",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82388",title:"Epigenetics: Science of Changes without Change in DNA Sequences",doi:"10.5772/intechopen.105039",signatures:"Jayisha Dhargawe, Rita Lakkakul and Pradip Hirapure",slug:"epigenetics-science-of-changes-without-change-in-dna-sequences",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Modifications of Biomolecules",coverURL:"https://cdn.intechopen.com/books/images_new/11098.jpg",subseries:null}},{id:"82583",title:"Leukaemia: The Purinergic System and Small Extracellular Vesicles",doi:"10.5772/intechopen.104326",signatures:"Arinzechukwu Ude and Kelechi Okeke",slug:"leukaemia-the-purinergic-system-and-small-extracellular-vesicles",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82531",title:"Abnormal Iron Metabolism and Its Effect on Dentistry",doi:"10.5772/intechopen.104502",signatures:"Chinmayee Dahihandekar and Sweta Kale Pisulkar",slug:"abnormal-iron-metabolism-and-its-effect-on-dentistry",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - A Double-Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}}]},subseriesFiltersForOFChapters:[{caption:"Chemical Biology",value:15,count:2,group:"subseries"},{caption:"Proteomics",value:18,count:2,group:"subseries"},{caption:"Cell and Molecular Biology",value:14,count:17,group:"subseries"},{caption:"Metabolism",value:17,count:18,group:"subseries"}],publishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"10664",title:"Animal Reproduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",slug:"animal-reproduction",publishedDate:"May 25th 2022",editedByType:"Edited by",bookSignature:"Yusuf Bozkurt and Mustafa Numan Bucak",hash:"2d66af42fb17d0a6556bb9ef28e273c7",volumeInSeries:11,fullTitle:"Animal Reproduction",editors:[{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",slug:"animal-feed-science-and-nutrition-production-health-and-environment",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Amlan Kumar Patra",hash:"79944fc8fbbaa329aed6fde388154832",volumeInSeries:10,fullTitle:"Animal Feed Science and Nutrition - Production, Health and Environment",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10496",title:"Advanced Studies in the 21st Century Animal Nutrition",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10496.jpg",slug:"advanced-studies-in-the-21st-century-animal-nutrition",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"László Babinszky, Juliana Oliveira and Edson Mauro Santos",hash:"8ffe43a82ac48b309abc3632bbf3efd0",volumeInSeries:8,fullTitle:"Advanced Studies in the 21st Century Animal Nutrition",editors:[{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Animal Nutrition",value:20,count:2},{group:"subseries",caption:"Animal Reproductive Biology and Technology",value:28,count:4},{group:"subseries",caption:"Animal Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:25,paginationItems:[{id:"429683",title:"Dr.",name:"Bilal",middleName:null,surname:"Khalid",slug:"bilal-khalid",fullName:"Bilal Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/429683/images/system/429683.png",biography:"Dr. Bilal Khalid received a Ph.D. in Industrial Business Administration from KMITL Business School, Bangkok, in 2021, and a master’s in International Business Management from Stamford International University, Bangkok, in 2017. Dr. Khalid\\'s research interests include leadership and negotiations, digital transformations, gamification, eLearning, blockchain, Big Data, and management of information technology. Dr. Bilal Khalid also serves as an academic editor at Education Research International and a reviewer for international journals.",institutionString:"KMITL Business School",institution:{name:"King Mongkut's Institute of Technology Ladkrabang",country:{name:"Thailand"}}},{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",institution:{name:"Université Laval",country:{name:"Canada"}}},{id:"189147",title:"Dr.",name:"Hailan",middleName:null,surname:"Salamun",slug:"hailan-salamun",fullName:"Hailan Salamun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189147/images/19274_n.jpeg",biography:"Hailan Salamun, (Dr.) was born in Selangor, Malaysia and graduated from Tunku Ampuan Jamaah Religious High School at Shah Alam. Obtained a degree from the International Islamic University (UIA), Gombak in the field of Islamic Revealed Knowledge and Heritage. Next, I furthered my studies to the professional level to obtain a Diploma in Education at UIA. After serving for several years in school, I furthered my studies to the Master of Dakwah and Leadership at Universiti Kebangsaan Malaysia (UKM), Bangi. I graduated with a Doctor of Philosophy in Principalship Leadership from the University of Malaya (UM) in 2010. I am currently a senior lecturer in the Department of Nationalism and Civilization, Center for Basic and Continuing Education, Universiti Malaysia Terengganu. Prior to that, I had served in several educational institutions such as schools, the Institute of Teacher Education (IPG), and also the University of Malaya. I am also actively involved in paper presentation, writing and publishing. My research interests are focused on leadership, education, society and Islamic civilization. This area of research requires a detailed understanding of Islamic studies and research studies in leadership. Another research interest that I have explored recently is the politics of the Malay community and also the leadership of the mosque.",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"442081",title:"Dr.",name:"Audrey",middleName:null,surname:"Addy",slug:"audrey-addy",fullName:"Audrey Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kwame Nkrumah University of Science and Technology",country:{name:"Ghana"}}},{id:"442083",title:"Dr.",name:"James",middleName:null,surname:"Addy",slug:"james-addy",fullName:"James Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ghana Health Service",country:{name:"Ghana"}}},{id:"437993",title:"Mr.",name:"Job",middleName:null,surname:"Jackson",slug:"job-jackson",fullName:"Job Jackson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Management College of Southern Africa",country:{name:"South Africa"}}},{id:"437991",title:"Prof.",name:"Muhammad",middleName:null,surname:"Hoque",slug:"muhammad-hoque",fullName:"Muhammad Hoque",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Management College of Southern Africa",country:{name:"South Africa"}}},{id:"428495",title:"Prof.",name:"Asyraf",middleName:null,surname:"Ab Rahman",slug:"asyraf-ab-rahman",fullName:"Asyraf Ab Rahman",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"421024",title:"Prof.",name:"Harold Andrew",middleName:null,surname:"Patrick",slug:"harold-andrew-patrick",fullName:"Harold Andrew Patrick",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jain University",country:{name:"India"}}},{id:"429650",title:"Dr.",name:"Jacqueline",middleName:null,surname:"Kareem",slug:"jacqueline-kareem",fullName:"Jacqueline Kareem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Christ University",country:{name:"India"}}},{id:"421041",title:"Dr.",name:"Sunil",middleName:null,surname:"Kumar Ramdas",slug:"sunil-kumar-ramdas",fullName:"Sunil Kumar Ramdas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jain University",country:{name:"India"}}},{id:"421833",title:"Mr.",name:"Eugene",middleName:null,surname:"Owusu-Acheampong",slug:"eugene-owusu-acheampong",fullName:"Eugene Owusu-Acheampong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"421826",title:"Dr.",name:"Inusah",middleName:null,surname:"Salifu",slug:"inusah-salifu",fullName:"Inusah Salifu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"420823",title:"Prof.",name:"Gardênia da Silva",middleName:null,surname:"Abbad",slug:"gardenia-da-silva-abbad",fullName:"Gardênia da Silva Abbad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Brasília",country:{name:"Brazil"}}},{id:"437613",title:"MSc.",name:"Juliana",middleName:null,surname:"Legentil",slug:"juliana-legentil",fullName:"Juliana Legentil",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Brasília",country:{name:"Brazil"}}},{id:"239876",title:"Ph.D.",name:"Luciana",middleName:null,surname:"Mourão",slug:"luciana-mourao",fullName:"Luciana Mourão",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Salgado de Oliveira",country:{name:"Brazil"}}},{id:"421735",title:"Dr.",name:"elizabeth",middleName:null,surname:"addy",slug:"elizabeth-addy",fullName:"elizabeth addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421006",title:"Dr.",name:"Anna",middleName:null,surname:"Uster",slug:"anna-uster",fullName:"Anna Uster",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470243",title:"Dr.",name:"Md Samim",middleName:null,surname:"Al Azad",slug:"md-samim-al-azad",fullName:"Md Samim Al Azad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470244",title:"Dr.",name:"Slimane",middleName:null,surname:"Ed-dafali",slug:"slimane-ed-dafali",fullName:"Slimane Ed-dafali",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421011",title:"Dr.",name:"Afatakpa",middleName:null,surname:"Fortune",slug:"afatakpa-fortune",fullName:"Afatakpa Fortune",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"446057",title:"Mr.",name:"Okedare",middleName:null,surname:"David Olubukunmi",slug:"okedare-david-olubukunmi",fullName:"Okedare David Olubukunmi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421778",title:"Dr.",name:"Fatimah",middleName:"Saeed",surname:"AlAhmari",slug:"fatimah-alahmari",fullName:"Fatimah AlAhmari",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421065",title:"Ms.",name:"Euzália",middleName:null,surname:"do Rosário Botelho Tomé",slug:"euzalia-do-rosario-botelho-tome",fullName:"Euzália do Rosário Botelho Tomé",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421053",title:"Associate Prof.",name:"Ken",middleName:null,surname:"Kalala Ndalamba",slug:"ken-kalala-ndalamba",fullName:"Ken Kalala Ndalamba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},onlineFirstChapters:{paginationCount:2,paginationItems:[{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. Barderas",slug:"oxidative-stress-in-cardiovascular-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"82291",title:"The Role of Oxidative Stress in the Onset and Development of Age-Related Macular Degeneration",doi:"10.5772/intechopen.105599",signatures:"Emina Čolak, Lepša Žorić, Miloš Mirković, Jana Mirković, Ilija Dragojević, Dijana Mirić, Bojana Kisić and Ljubinka Nikolić",slug:"the-role-of-oxidative-stress-in-the-onset-and-development-of-age-related-macular-degeneration",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}}]},publishedBooks:{paginationCount:5,paginationItems:[{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/188886",hash:"",query:{},params:{id:"188886"},fullPath:"/profiles/188886",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var m;(m=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(m)}()