\r\n\tThis book will mainly cover work related to: (i) cells mechanosensing and mechanotransduction mechanisms (ii) computational and experimental techniques in mechanobiology, (iii) mathematical mechanobiological models of bone remodeling, (iv) bone mechano-transduction, (v) innovative tools for mechanobiology and the role of medical imaging in this field and (vi) any other proposals related to innovations, clinical application and perspectives of mechanobiology.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"0a38ccecc83b50d8b015a6dd2533049d",bookSignature:"Prof. Abdelwahed Barkaoui",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10255.jpg",keywords:"Nuclear Mechanotransduction, Mechanosensitivity, Fluids Mechanics, Multiscale Mechanobiology, Modeling Cellular Mechanics, Finite Elements Method, Bone Remodeling, Mechanics Stimulus, Multi-scale Modeling, Mechanobiology Tools, Cell Imaging, Cell-Substrate Interactions",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 2nd 2020",dateEndSecondStepPublish:"July 23rd 2020",dateEndThirdStepPublish:"September 21st 2020",dateEndFourthStepPublish:"December 10th 2020",dateEndFifthStepPublish:"February 8th 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Assistant director of LERMA laboratory, head of mechanical discipline at ECINE and coordinator of the ECINE study program accreditation committee, a member of the editorial board of several international scientific journals, also a member of the American Society of Mechanical (ASME) Engineers European Society of Biomechanics (ESB) and the International Society of Biomechanics (ISB).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"320631",title:"Dr.",name:"Abdelwahed",middleName:null,surname:"Barkaoui",slug:"abdelwahed-barkaoui",fullName:"Abdelwahed Barkaoui",profilePictureURL:"https://mts.intechopen.com/storage/users/320631/images/system/320631.jpg",biography:"Abdelwahed BARKAOUI is an Associate Professor of Mechanical Engineering at the International University of Rabat. He obtained his University habilitation from the University of Tunis El Manar-Tunisia in 2017 and his Ph.D. from the University of Orleans, France in 2012. He has a master\\'s degree in mechanics obtained from the INSA of Lyon, France, and an engineering diploma in electromechanics from ENI-Sfax, Tunisia. Currently, dr. BARKAOUI is the assistant director of the LERMA laboratory and coordinator of the Modelling & Simulation in Biomechanics & Biomaterials (MS2B) team. He is responsible for the mechanical discipline and coordinator of the ABET accreditation project at the Higher School of Energy Engineering. His research is focused on biomechanics, mechanobiology, and biomedical engineering. He was a member of the editorial board of several international scientific journals such as Frontiers in Bioengineering and Biotechnology “Biomechanics” (IF=5,9), BMC Musculoskeletal Disorders (IF:2.6), BMC Biomedical Engineering, Series on Biomechanics, as well as a reviewer for several international journals\nin the field of biomechanics and mechanical engineering. Dr. BARKAOUI is the author of more than 60 publications in international journals, books, and conferences.",institutionString:"International University of Rabat",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"International University of Rabat",institutionURL:null,country:{name:"Morocco"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Approximately 85% of babies born at term will initiate spontaneous respirations within 10 to 30 seconds of birth, an additional 10% will respond during drying and stimulation, approximately 3% will initiate respirations after PPV, 2% will be intubated to support respiratory function, and 0.1% will require CC and/or epinephrine to achieve this transition [4, 5, 6]. When newborns fail to initiate spontaneous breathing, the International Liaison Committee on Resuscitation (ILCOR) recommend several steps to support the transition of newborn infants [4, 5, 6]. The initial steps of stabilization algorithm include providing warmth to maintain a normal body temperature by
NRP algorithm.
The initial steps of newborn stabilization/resuscitation are to maintain normal temperature of the infant, position the infant in a “sniffing” position to open the airway, clear secretions if needed with a bulb syringe or suction catheter, dry the infant, and stimulate the infant [4, 5, 6]. Most newborn infants are breathing or crying and have good tone immediately after birth [7, 8]. However, they must be dried and kept warm to avoid hypothermia, which can happen while the baby is lying on the mother’s chest to avoid separation of mother and baby [4, 5, 6]. Maintaining normal temperature after birth is crucial due to a dose-dependent increase in mortality for temperatures <36.5°C [9]. Simple interventions (e.g., skin-to-skin contact or kangaroo mother care, plastic wrap, radiant warmer, thermal mattress, or warmed humidified resuscitation gases) to prevent hypothermia during transition (birth until 1 to 2 hours of life) can reduce mortality [4, 5, 6, 10, 11]. Maternal hyperthermia in labor is associated with adverse neonatal effects including increased mortality, neonatal seizures, and adverse neurologic states like encephalopathy [4, 5, 6]. Similarly, neonatal hyperthermia >38.0°C should be avoided due to the potential associated risks [4, 5, 6].
Suctioning immediately after birth, whether with a bulb syringe or suction catheter, should only be done if the airway appears obstructed or if PPV is required [4, 5, 6]. Avoiding unnecessary suctioning helps prevent the risk of induced bradycardia due to suctioning of the nasopharynx [4, 5, 6]. The presence of meconium-stained amniotic fluid may indicate fetal distress and increases the risk that the infant will require resuscitation after birth; therefore, a team that includes an individual skilled in tracheal intubation should be present at the time of birth [4, 5, 6]. Any infant who is vigorous with good respiratory effort and muscle tone may stay with their mother to receive the initial steps of newborn care [4, 5, 6]. Any infant presenting with poor muscle tone and inadequate breathing efforts after being born through meconium-stained amniotic fluid should receive the initial steps of resuscitation under a radiant warmer [4, 5, 6]. PPV should be initiated if the infant is not breathing or the heart rate is less than 100/min after the initial steps are completed [4, 5, 6]. Routine intubation for tracheal suction in this setting is not suggested, because there is insufficient evidence to continue recommending this practice [4, 5, 6].
Tactile stimulation including warming, drying, and rubbing the back or the soles of the feet is recommended in the current ILCOR guidelines [4, 5, 6]. Tactile stimulation is the first step to stimulate spontaneous breathing in newborn infants [4, 5, 6]. Retrospective studies reported a large variability in the use of tactile stimulation during the stabilization of infants at birth [12]. Furthermore, a recent randomized trial reported an increase in respiratory effort during repetitive stimulation compared to standard tactile stimulation with less oxygen requirements during transport to the NICU [13]. However, it did not reach significance, and further studies are needed.
The fetal oxygen saturation before birth is between 40 and 60% [14], which increases in uncompromised term infants within the first 10 minutes following birth to levels between 90 and 100% [15], thus resulting in the appearance of cyanosis during that time [16]. In addition, clinical assessment of skin color or the lack of cyanosis is a very poor indicator of oxygen saturation during that period [16, 17, 18, 19]. The optimal management of oxygen during neonatal resuscitation becomes particularly important because of the evidence that either insufficient or excessive oxygenation can be harmful to the term infant with hypoxia and ischemia are known to result in injury to multiple organs and hyperoxia causing increased mortality [16, 20, 21]. Therefore, infants >35 weeks’ gestation should be resuscitated in 21% oxygen and oxygen should be increased only if heart rate does not increase despite adequate ventilation.
Approximately, 10% of newborns require respiratory support at birth [22]. ILCOR and various national guidelines recommend techniques and equipment for neonatal resuscitation [4, 5, 6]. They all agree that mask ventilation is the cornerstone of respiratory support immediately after birth [4, 5, 6]. The purpose of PPV is to establish FRC, deliver an adequate VT to facilitate gas exchange, and stimulate breathing while minimizing lung injury [2]. Several factors can reduce the effectiveness of mask ventilation, including poor face mask technique resulting in leak or airway obstruction, spontaneous movements of the baby, movements by or distraction of the resuscitator, and procedures such as changing the wraps or fitting a hat [23, 24]. Delivery room studies have shown that mask PPV is difficult, and mask leak and airway obstruction are common [23, 24, 25, 26, 27, 28, 29]. Both leak and obstruction are usually unrecognized unless expired CO2 detectors or respiratory function monitors (RFM) are used [23, 24, 25, 26, 27, 28, 29]. In addition, airway maneuvers (e.g., jaw thrust or chin lift) to maintain airway patency is a crucial step during mask PPV [30].
There is currently limited evidence to guide clinicians’ choice of the device to be used to provide PPV in the DR [31]. Self-inflating bags, flow-inflating bags, or T-piece devices may all be used for mask PPV [4, 5, 6]. A self-inflating bag, however, does not provide PEEP or continuous positive airway pressure (CPAP) [32, 33]. An attached PEEP-valve provides inconsistent PEEP and cannot deliver CPAP [32, 33, 34, 35, 36, 37]. A flow-inflating bag provides variable and operator dependent PEEP [16, 38]. With a T-piece device more consistent, predetermined levels of PEEP and PIP can be delivered [34, 35]. In addition, a T-piece device has been shown to be the most accurate device for delivering a sustained inflation [35, 39, 40, 41].
Effective and consistent PPV is important to facilitate lung aeration, establishment of a functional residual capacity, and gas exchange, which should occur in a predictable manner so that the clinician can avoid under- or over-inflating the lungs [2, 42, 43, 44]. However, PPV is often complicated by mask leak or airway obstruction [23, 24, 25, 26, 27, 28, 29]. Currently, clinicians can either use a face mask or a nasal prong during mask PPV [4, 5, 6]; however, face mask ventilation remains the primary mode of resuscitation. There are a variety of face masks available to provide PPV [25, 45, 46]. The Fisher & Paykel (F&P) (Fisher & Paykel Healthcare, Auckland, New Zealand) and the Laerdal round masks are the most commonly used commercially available products [47, 48, 49, 50, 51, 52]. Although, face masks for preterm infants <33 weeks’ do not adequately fit their face [53], the only study comparing F&P vs. Laerdal masks reported no difference in mask leak during PPV in the DR in preterm infants <33 weeks’ [25]. Similarly, two studies compared face masks to nasal prongs in the DR and reported no difference in intubation in the delivery room [45, 46]. These data suggest that either face mask or nasal prong could be used for PPV in the DR and the focus should rather be on delivery of an adequate tidal volume to achieve lung aeration.
Archie Brain, a British anesthetist, described the laryngeal mask airway (LMA) as an alternative to endotracheal intubation in 1981 [54]. A LMA consists of an airway tube connected distally to a soft elliptical mask with an inflatable rim to fit over the laryngeal inlet, whereas the proximal end connects to the ventilation device [54]. LMAs are routinely used in emergency and operating rooms for adult and pediatric anesthesia and ambulance services [55, 56]. In newborn infants, there is increasing evidence from randomized trials [57, 58], suggesting that a LMA can provide an effective rescue airway during resuscitation if both mask ventilation and endotracheal intubation have been unsuccessful. Current neonatal resuscitation guidelines recommend the use of LMA in infants >34 weeks’ gestation or > 2000 g birth weight. Furthermore, LMA have been described during neonatal transport [59, 60, 61], provision of prolonged mechanical ventilation in particular for infants with upper airway abnormalities [62, 63, 64], and surfactant and epinephrine administration [65, 66, 67, 68, 69]. Although LMAs are recommended by various neonatal resuscitation guidelines, they are not routinely used during neonatal resuscitation [4, 5, 6].
In 1907, Sir Fredrick Hewitt presented the first known artificial oral “air-way” to alleviate upper airway obstruction, a common problem during general anesthesia [31]. In 1933, Arthur Guedel presented “the Guedel oropharyngeal airway” [37], designed to hold the tongue away from the back of the pharynx, thus providing a clear channel for respired gases [70]. An oropharyngeal airways may be used to open the airway in floppy newborn infants, or if mask ventilation is ineffective [71, 72, 73, 74]. In addition, various surveys evaluating neonatal resuscitation practice reported that Guedel airways are part of the neonatal resuscitation equipment [50, 75]. Guedel airways for newborn infants come in traditional sizes of 000, 00, and 0. However, oropharyngeal airways during neonatal resuscitation have not been systematically studied, and only one trial is currently ongoing comparing an oropharyngeal airway for prevention of airway obstruction during PPV in preterm infants <34 weeks’ gestation in the DR [49]. Until further evidence is available, oropharyngeal airway should be used with caution.
When infants fail to initiate spontaneous breathing, the current neonatal resuscitation guidelines recommend mask PPV using any above described ventilation devices coupled with a face mask or a nasal prong [4, 5, 6]. The purpose of PPV is to establish FRC, deliver an adequate VT to facilitate gas exchange, and stimulate breathing while minimizing lung injury [2]. The current neonatal resuscitation guidelines further recommend to use a peak inflation pressure of around 30 cm H2O, a positive end expiratory pressure of 5 cm H2O when using a T-Piece or a flow-inflating bag, and a gas flow rate of 10 L/min and 21% oxygen [4, 5, 6]. Oxygen should only be increased if the infant requires chest compression (see the paragraph below), the heart rate does not increase despite adequate ventilation, or if SpO2 is below the recommend target range [4, 5, 6]. If infants have adequate spontaneous respiration, but remain cyanotic (e.g., SpO2 is below the recommend target range [4, 5, 6]) during the initial stabilization, CPAP using pressures between 5 and 8 cm H2O should be provided using a T-Piece or a flow-inflating bag (see the paragraph about ventilation devices).
There is no need for any other ventilation modalities (e.g., high frequency ventilation or mechanical ventilation) in the delivery room, which should be done in the NICU.
During fetal development, surfactant production starts at around 24–26 weeks’ gestation with a continuous increase in production up to 36 weeks’ gestation. At that time, the surfactant production is similar to that of adults. Term infants rarely require surfactant in the delivery room and surfactant should be given only after the infants have been admitted to the NICU. Using this approach will allow for a more gentle intubation with recued stress for the resuscitation team. Potential indications for surfactant administration include transient tachypnea of the newborn, meconium aspiration syndrome, respiratory distress syndrome, pulmonary hemorrhage, or presumed sepsis with secondary surfactant consumption.
About 0.1% of term infants and up to 15% of preterm infants [76, 77] receive chest compression (CC) or epinephrine in the DR, which results in ∼1 million newborn deaths annually worldwide. Infants who received epinephrine in the DR had a high incidence of mortality (41%) and short-term neurologic morbidity (57% hypoxic-ischemic encephalopathy and seizures) [78]. Furthermore, newborns receiving prolonged CC and epinephrine with no signs of life at 10 minutes following birth have up to 83% mortality, with 93% of survivors suffering moderate-to-severe disability [79]. Asphyxia could result from either failure of placental gas exchange before delivery (e.g., abruption and chorioamnionitis) or deficient pulmonary gas exchange immediately after birth (e.g., pulmonary hypertension) [80]. This condition of impaired gas exchange with simultaneous hypoxia and hypercapnia is leading to a mixed metabolic and respiratory acidosis [80]. Newborn infants are typically born with severe bradycardic or asystole. Current resuscitation guidelines recommend CC if the heart rate remains <60/min despite adequate PPV with 100% oxygen for 30 seconds; CC should be then performed at a rate of 90/min with 30 ventilations 3:1 C:V (compression:ventilation) ratio [4, 5, 6]. Rationales for using a 3:1 C:V ratio include (i) higher physiological heart rate (120–160/min) and breathing rates (40–60/min) in newborns compared to adults; (ii) profound bradycardia or cardiac arrest caused by hypoxia rather than primary cardiac compromise; therefore, providing ventilation is more likely to be beneficial in neonatal CPR compared to adult CPR [4, 5, 6].
However, the optimal C:V ratio that should be used during neonatal resuscitation to optimize coronary and cerebral perfusion while providing adequate ventilation of an asphyxiated newborn remains unknown [81]. Studies using newborn piglets with asphyxia-induced cardiac arrest demonstrated that combining CC with ventilations improves the return of spontaneous circulation (ROSC) and neurological outcome at 24 hours compared to ventilations or CC alone [16, 21]. Animal studies comparing various C:V ratios including 2:1 C:V, 4:1 C:V, 9:3 C:V, and 15:2 C:V to 3:1 C:V reported no difference in ROSC, survival or any other outcomes [82, 83, 84]. These studies suggest that during neonatal CPR, higher C:V ratios do not improve outcomes, and potentially a higher ventilation rate is needed. Similarly,
Most recently, a new technique providing CC during a sustained inflation (SI) (CC + SI) has been proposed, which significantly improved hemodynamics, minute ventilation, and time to ROSC compared to the 3:1 C:V ratio during resuscitation of asphyxiated newborn piglets [86]. While this first study used a CC rate of 120/min (in the CC + SI group) instead of the recommended 90/min, further studies using CC rates of 90/min in the same animal model have confirmed the initial findings [87, 88, 89, 90]. Also a recent pilot trial in preterm infants <32 weeks’ gestation showed similar results to the animal studies with a reduction in the mean (SD) time to ROSC with 31 (9) sec vs. 138 (72) sec in the CC + SI group and 3:1 C:V group (p = 0.011), respectively [91]. These data suggest that CC + SI has the potential to improve neonatal CPR, and a large randomized trial is currently ongoing to compare CC + SI with 3:1 C:V. Until these data are available, the 3:1 C:V ratio should be used during neonatal CPR.
There are no general rules about the presences of parents in delivery room during stabilization of their newborn. The approach chosen at any given facility will depend on (i) the local policy, (ii) geographical situation (e.g., separate stabilization room away from where the baby was delivered), and (iii) comfort of attending staff having parents in the room and observing the team. In addition, the increased use of smartphones and the urge of parents to photo document or video record, the resuscitation can add additional stress to the resuscitation team. In our institution, there is a geographical separation of the delivery suite and the stabilization room for high-risk deliveries. While the mother is unable to observe the resuscitation/stabilization, the father/partner would join the resuscitation team to be with their baby (father/partner is allowed to take photos, but not to video record) and would go back and forth between the stabilization room and the delivery suite to communicate with the mother. However, every hospital has to develop their own policy according to their needs to allow parents attendance during delivery and resuscitation.
Among the 15% of term babies who do not initiate spontaneous respirations after birth, 10% will require initial steps of stabilization: maintain normal temperature of the infant due to a dose-dependent increase in mortality for decreases of body temperature, position the infant in a “sniffing” position to open the airway, clear secretions with a bulb syringe or suction catheter if needed (if the airway appears obstructed or if PPV is required within 10–30 seconds of birth), dry the infant, and stimulate the infant (rubbing the back or the soles of the feet). Approximately 3% of term babies who do not initiate spontaneous respirations after birth will require PPV. Self-inflating bags, flow-inflating bags or T-piece devices may all be used for mask PPV, with currently limited evidence on the best device to be used to provide PPV in the DR. Among the interfaces, either face masks or nasal prongs could be used for PPV. Other interfaces that can be used are laryngeal mask and Guedel oropharyngeal airway. Lastly, approximately 2% of term babies who do not initiate spontaneous respirations after birth will be intubated and 0.1% will require CC and/or epinephrine to achieve this transition: current resuscitation guidelines recommend CC if the heart rate remains <60/min despite adequate PPV with 100% oxygen for 30 seconds; CC should be then performed at a rate of 90/min with a 3:1 C:V ratio. However, the optimal C:V ratio that should be used during neonatal resuscitation of an asphyxiated newborn remains unknown, with several ongoing studies assessing other techniques.
Property is simply a collection of rights arising from the concepts of ownership and possession in the legal sense. While most of them have a physical existence, the importance or significance of property is determined by the knowledge of its intended purpose.
Only when there is an idea/technology, it has been utilized as a matter in such a way that it can meet a human need/demand does it become resource. Either idea or technology becomes a resource in two ways, and they are
Material resource
Intellectual or technological resource.
Altogether the property rights are restricted or constrained by other people’s rights. Each property right is outlined and established in practice to ensure that it is balanced with other property rights.
Intellectual property is a type of property generated/created by the human minds based on their intelligence. Novelty or originality of this intellectual property diverges from one system to the others, which has a finite life span [1].
According to intellectual property, ideas are a representation of the creator’s identity or self, which need to be protected.
Different rights such as Patents, trademarks, copyrights, protection of undisclosed information, traditional knowledge, geographical indicators, industrial designs, and integrated circuits as layout designs are examples of intellectual property rights, which are recognized by the Trade Related Intellectual Property Rights Agreement (TRIPS) and governed by the World Trade Organization (WTO) (World Trading Organization).
Intellectual property rights are the rights granted to individuals over their mental inventions, and they grant an exclusive right to the inventor to utilize their product for a set length of time. This exclusive right to the inventor for their invention can encourage the technical process by
Inspire the innovation and research.
Inspire an innovator to reveal their inventions.
Offering award as a prize to help with the costs for creating new inventions.
Provides a financial incentive to invest in new lines of production that may or may not be lucrative [2].
Various Congresses in Vienna and the rest of Europe laid the groundwork for International Intellectual Property Protection in the nineteenth century. In 1883, the Paris Convention established the protection of industrial property. In this Paris Convention patents, trademarks and industrial design properties were accorded protection.
The Paris Convention established the first international trademark legislation and the concept of a well-known mark. For countries that are members of the Paris Convention, special unions and arrangements have been formed. Also in this Paris Convention, fundamental principles of Madrid agreement were outlined and represented. This Madrid Agreement is a unique agreement that was established to standardize trademarks [3, 4, 5].
Protection of literary and artistic works was framed in Berne Convention during 1886, and subsequently, International Copyright Act was passed [6].
The General Agreement on Tariffs and Trade (GATT) was negotiated on Trade and Employment Conference held in the United Nations even after negotiating governments failed to establish the International Trade Organization (ITO). The GATT was established in 1949 and lasted until 1993, when it was succeeded by the World Trade Organization, which was established in 1995 [7, 8].
The World Intellectual Property Organization (WIPO) was created in 1960, which governs both the Paris and Berne Conventions. These conventions led to establish the World Intellectual Property Organization (WIPO) in 1967 [9].
The United Nations Conference on Trade and Development (UNCTAD) was founded in 1964 to provide a venue to discuss issues concerning their economic development for developing countries. The organization’s goals are to help developing countries to maximize their trade, investment, and development prospects. In addition, the organization assists the developing countries for their efforts to integrate into the global economy fairly [10].
In 1960, global trade expanded substantially, and various National Governments realized the necessity of setting norms and rules worldwide to integrate the disparate National and regional regulations that had previously controlled. In 1966, the United Nations General Assembly established the United Nations Commission on International Trade Law (UNCITRAL) to promote the progressive harmonization and unification of international trade law [11].
World Trade Organization (WTO) was established in the year 1995 and it has become an international organization for understanding the various IPR [12].
Several corporate organizations to ensure their continued growth, higher profits, and leadership in market premeditated their project management system for
Utilization of the inter-/intra-knowledge base to its full potential.
Management of IPR on a strategic level.
Receiving knowledge and inventions as inputs from various external sources.
Managing the collaborative research by internal expertise members.
Provide mutually beneficial licenses among the knowledge ownerships.
In the future, the developing prospect will look for effective linkages between increasing societal rivalry on the one hand and establishing legal ownership of innovations on the other hand.
Knowledge, technology management, and process are incorporated in the intertwined societal, moral, and ethical challenges as the influencing approached for the several international trade.
In the upcoming decades, this technology explores new dimensions from unknown paths. This IPR will encourage for more innovation and knowledge sharing between this highly competitive networks. Various intertwined IPR are
Domain names and trademarks: In cyberspace, copyright is protected.
Traditional knowledge, prior art, material transfer agreements, and bio-prospecting rights are all protected.
Patents and software.
Biotechnological inventions.
Optional compulsory licensing, border measures, parallel imports, and IPR exhaustion
Export of technology is regulated by the government [13].
During that time, an extensive debate has been taken place about the restrictions of Intellectual Property Rights on the developing countries.
The relative intensity of their technical activity determines the potential significance of IPR in developing countries. Developing countries agreed to the TRIPS agreement for various reasons, ranging from the prospect of increased access to rich countries’ agricultural and clothing markets to the belief that stronger intellectual property rights would foster more knowledge transfer and innovation. However, in many countries, particularly in the poorest, the long-term advantages are unknown and costly to attain. But they believe that they will be having a favorable impact by enforcing the IPR. It also points out that IPRs have had variable degrees of growth effects at different eras and in different parts of the world, with countries achieving high growth rates under varying degrees of IPR protection. Stronger IPRs undoubtedly have short-term consequences for poor countries, such as higher pricing for technology and protected items [14].
Benefits of exclusive rights to innovations are
Inspiration of innovations by private organization and other enterprises.
For productive activity utilizing the new knowledge.
Spreading the new knowledge to the other organization [15].
Intellectual property rights are broadly divided into two main areas.
They are copyright and related rights and industrial property.
Copyright protects the rights of writers of literary and artistic works, which includes books, writings, paintings, musical compositions, sculpture, films, and computer programs for a minimum of 50 years after the author’s death after the work is published.
The rights of performers like actors, musicians, and singers; creators of phonograms such as sound recordings; and broadcasting companies are also protected by copyright and related rights, which is referred as neighboring rights.
The main purpose of copyright and related rights protection is to stimulate and reward the innovative creative work.
Industrial property is broadly divided into two main areas.
One area is the protection of distinctive signs, such as trademarks (which differentiate the goods, products, or services from those of others) and geographical indications (which identify a product as coming from a location where a specific characteristic of the product is essentially attributable to its geographical origin). The primary goal of trademark protection is to encourage and ensure fair competition, as well as to safeguard customers by allowing them to make educated decisions about diverse goods and services. If the symbol in question remains distinctive, the protection may extend eternally.
Other sorts of industrial property are safeguarded largely to encourage inspire innovation, design, and creation of technology development. Patented inventions, industrial designs, and trade secrets are all included in this category.
The social goal is to protect the results of investments in new technology development, thereby providing an incentive and means to fund research and development operations. Foreign direct investment, joint ventures, and licensing should all be made easier by a functioning intellectual property law. Typically, protection is granted for a set period of time (typically 20 years in the case of patents).
Intellectual property protection laws are founded on a variety of philosophical underpinnings and philosophies. In the area of tangible property, the majority of these notions are rotten. Intellectual property is fundamentally distinct from other types of property in some ways. Philosophical arguments are frequently employed to outline and define the bounds and breadth of protection in an age when intellectual regimes are being strengthened, reinterpreted, and challenged. As a result, it is critical to investigate and comprehend these arguments.
This IPR can protect the ideas and inspire the innovations, stimulating the creation of technology and innovations and design. Different types of IPR are designed, which can provide benefits by sharing the new invention as knowledge and assisting the technology transfer through licensing. Also, inspire the invention with joint venture for further development. The potential significance of IPR in developing countries is protecting their investment as incentives and inspire further development in the research, which can help to attain the desired technology advancement and economical status in this global competitive. IPR is the only key element in attaining the social, economic, and technological advancement.
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Nowadays, in the total pulp consumption of the world, the proportions of wood pulp, wastepaper pulp, and non-wood pulp are 63, 34, and 3%, respectively. The effective use of non-wood fiber resources, especially grasses, cereal straws, corn stalks, bamboo, and bagasse, would play a major role in optimizing papermaking raw materials. On the other hand, there are non-wood fibers such as flax, hemp, jute, kenaf, cotton, sisal, and abaca with properties as good as or much better than softwood materials.",book:{id:"6245",slug:"pulp-and-paper-processing",title:"Pulp and Paper Processing",fullTitle:"Pulp and Paper Processing"},signatures:"Zhong Liu, Huimei Wang and Lanfeng Hui",authors:[{id:"218005",title:"Prof.",name:"Zhong",middleName:null,surname:"Liu",slug:"zhong-liu",fullName:"Zhong Liu"},{id:"220665",title:"Prof.",name:"Lanfeng",middleName:null,surname:"Hui",slug:"lanfeng-hui",fullName:"Lanfeng Hui"},{id:"220666",title:"Dr.",name:"Huimei",middleName:null,surname:"Wang",slug:"huimei-wang",fullName:"Huimei Wang"}]},{id:"62258",doi:"10.5772/intechopen.79015",title:"Different Solvents for Organosolv Pulping",slug:"different-solvents-for-organosolv-pulping",totalDownloads:1687,totalCrossrefCites:11,totalDimensionsCites:19,abstract:"Organosolv pulping is a two-stage process involving hydrolysis (decomposition of wood by use of a catalyst) and removal of lignin with an organic solvent (usually a mixture of alcohol and water). The main disadvantage of using an alcohol is its low boiling point, which requires operating at a high pressure and hence using special equipment that is expensive to purchase and operate. One solution to this problem is using alternative organic solvents that afford operation at pressure levels similar to those of classic pulping processes (e.g., the Kraft process). This chapter provides a comprehensive literature review on the organosolv-based production of cellulose pulp by using alternative solvents such as glycols, phenols, esters, organic acids, acetone and amines.",book:{id:"6245",slug:"pulp-and-paper-processing",title:"Pulp and Paper Processing",fullTitle:"Pulp and Paper Processing"},signatures:"Alejandro Rodríguez, Eduardo Espinosa, Juan Domínguez-Robles,\nRafael Sánchez, Isabel Bascón and Antonio Rosal",authors:[{id:"218209",title:"Dr.",name:"Alejandro",middleName:null,surname:"Rodríguez",slug:"alejandro-rodriguez",fullName:"Alejandro Rodríguez"},{id:"221719",title:"Mr.",name:"Eduardo",middleName:null,surname:"Espinosa",slug:"eduardo-espinosa",fullName:"Eduardo Espinosa"},{id:"221720",title:"Dr.",name:"Juan",middleName:null,surname:"Domínguez-Robles",slug:"juan-dominguez-robles",fullName:"Juan Domínguez-Robles"},{id:"221722",title:"Dr.",name:"Rafael",middleName:null,surname:"Sánchez",slug:"rafael-sanchez",fullName:"Rafael Sánchez"},{id:"221723",title:"Mrs.",name:"Isabeñ",middleName:null,surname:"Bascón",slug:"isaben-bascon",fullName:"Isabeñ Bascón"},{id:"221724",title:"Dr.",name:"Antonio",middleName:null,surname:"Rosal",slug:"antonio-rosal",fullName:"Antonio Rosal"}]},{id:"63362",doi:"10.5772/intechopen.79749",title:"Pulping of Non-Woody Biomass",slug:"pulping-of-non-woody-biomass",totalDownloads:2055,totalCrossrefCites:9,totalDimensionsCites:14,abstract:"The use of trees for paper production has contributed to the problem of deforestation with radical negative impact on the environment thereby causing an imbalance in the ecosystem. An increase in the demand and consumption of paper has also induced depletion of woods resources for paper production, thus resulting in limited availability of the raw materials. This work examined the use of non-woody biomasses as alternative raw materials, which are accessible and convertible into pulp and paper of the same quality as those obtained from wood.",book:{id:"6245",slug:"pulp-and-paper-processing",title:"Pulp and Paper Processing",fullTitle:"Pulp and Paper Processing"},signatures:"Mayowa Akeem Azeez",authors:[{id:"197473",title:"Dr.",name:"Mayowa Akeem",middleName:null,surname:"Azeez",slug:"mayowa-akeem-azeez",fullName:"Mayowa Akeem Azeez"}]},{id:"51034",doi:"10.5772/63744",title:"Evaporative Drying of Low-Rank Coal",slug:"evaporative-drying-of-low-rank-coal",totalDownloads:2283,totalCrossrefCites:11,totalDimensionsCites:14,abstract:"Low-rank coals including the brown and the subbituminous coals are commonly known to contain high moisture content (up to 65%, wet basis), which limits their utilization around the world in spite of their low cost. Today, the most of the drying technologies are based on the evaporation of the water from the moist product. In this chapter, the most effective parameters on the evaporative coal-drying process are investigated with the data in the recent literature. The effective parameters are evaluated in three categories as follows: (1) the parameters about the drying media (the type of the media, the temperature, the pressure, the velocity and the relative humidity), (2) the coal parameters (the type of the coal and the size) and (3) the drying method.",book:{id:"5266",slug:"sustainable-drying-technologies",title:"Sustainable Drying Technologies",fullTitle:"Sustainable Drying Technologies"},signatures:"Saban Pusat, Mustafa Tahir Akkoyunlu and Hasan Hüseyin Erdem",authors:[{id:"181675",title:"Dr.",name:"Saban",middleName:null,surname:"Pusat",slug:"saban-pusat",fullName:"Saban Pusat"},{id:"181676",title:"MSc.",name:"Mustafa Tahir",middleName:null,surname:"Akkoyunlu",slug:"mustafa-tahir-akkoyunlu",fullName:"Mustafa Tahir Akkoyunlu"},{id:"181677",title:"Dr.",name:"Hasan Hüseyin",middleName:null,surname:"Erdem",slug:"hasan-huseyin-erdem",fullName:"Hasan Hüseyin Erdem"}]},{id:"51561",doi:"10.5772/64191",title:"Sustainable Drying Technologies for the Development of Functional Foods and Preservation of Bioactive Compounds",slug:"sustainable-drying-technologies-for-the-development-of-functional-foods-and-preservation-of-bioactiv",totalDownloads:2432,totalCrossrefCites:8,totalDimensionsCites:11,abstract:"Nowadays, the sustainability of a product, a process or a system is assessed according to three dimensions: environmental, social and economic. Sustainability challenges occur at all stages in the food system from production through processing, distribution and retailing to consumption and waste disposal. The promotion of organic and local food is not the only way to reach the sustainability. There is other possibility that implies to continue the production hegemony. Increasing research is being focused on the development of healthy, quality and safety food products adapted to consumer’s needs and more environment-friendly processes, that is, processes consuming energy more efficiently, generating less waste and emitting less greenhouse effect gases. Drying technology is applied in the food industry not only for preservation but also to manufacture foods with certain characteristics. Drying technology operations need to be precisely controlled and optimized in order to produce a good-quality product with the highest level of nutrient retention and flavor together with microbial safety. This chapter contains detailed information about some measurements taken by the food industry to ensure the supply of bioactive nutrients to as many individuals as possible, assuring the global sustainability. More specifically, the contribution of some drying techniques employed in the development of functional foods to increase the sustainability of the feeding process is discussed.",book:{id:"5266",slug:"sustainable-drying-technologies",title:"Sustainable Drying Technologies",fullTitle:"Sustainable Drying Technologies"},signatures:"Ester Betoret, Laura Calabuig-Jiménez, Cristina Barrera and Marco\nDalla Rosa",authors:[{id:"182749",title:"Ph.D.",name:"Ester",middleName:null,surname:"Betoret",slug:"ester-betoret",fullName:"Ester Betoret"},{id:"190053",title:"MSc.",name:"Laura",middleName:null,surname:"Calabuig-Jiménez",slug:"laura-calabuig-jimenez",fullName:"Laura Calabuig-Jiménez"},{id:"190056",title:"Dr.",name:"Cristina",middleName:null,surname:"Barrera",slug:"cristina-barrera",fullName:"Cristina Barrera"},{id:"190058",title:"Dr.",name:"Marco",middleName:null,surname:"Dalla Rosa",slug:"marco-dalla-rosa",fullName:"Marco Dalla Rosa"}]}],mostDownloadedChaptersLast30Days:[{id:"62223",title:"Pulping and Papermaking of Non-Wood Fibers",slug:"pulping-and-papermaking-of-non-wood-fibers",totalDownloads:4041,totalCrossrefCites:25,totalDimensionsCites:42,abstract:"In general, the main raw materials of pulp and papermaking industry can be classified into three categories: wood, non-wood, and non-plant (mainly wastepaper), of which non-wood fiber material is an important fiber source in the areas where forest resources are scarce. Nowadays, in the total pulp consumption of the world, the proportions of wood pulp, wastepaper pulp, and non-wood pulp are 63, 34, and 3%, respectively. The effective use of non-wood fiber resources, especially grasses, cereal straws, corn stalks, bamboo, and bagasse, would play a major role in optimizing papermaking raw materials. On the other hand, there are non-wood fibers such as flax, hemp, jute, kenaf, cotton, sisal, and abaca with properties as good as or much better than softwood materials.",book:{id:"6245",slug:"pulp-and-paper-processing",title:"Pulp and Paper Processing",fullTitle:"Pulp and Paper Processing"},signatures:"Zhong Liu, Huimei Wang and Lanfeng Hui",authors:[{id:"218005",title:"Prof.",name:"Zhong",middleName:null,surname:"Liu",slug:"zhong-liu",fullName:"Zhong Liu"},{id:"220665",title:"Prof.",name:"Lanfeng",middleName:null,surname:"Hui",slug:"lanfeng-hui",fullName:"Lanfeng Hui"},{id:"220666",title:"Dr.",name:"Huimei",middleName:null,surname:"Wang",slug:"huimei-wang",fullName:"Huimei Wang"}]},{id:"59931",title:"Abrasive for Chemical Mechanical Polishing",slug:"abrasive-for-chemical-mechanical-polishing",totalDownloads:2556,totalCrossrefCites:5,totalDimensionsCites:10,abstract:"Chemical mechanical polishing (CMP) is one of the most essential processes in semiconductor manufacturing. Its importance becomes highly underscored at the advanced device toward sub 14 nm scaling. The fundamental mechanism of CMP is to create soften surface layer by chemical reaction and then, mechanical force by abrasive particles remove soften layer. The role of CMP is not only material removal, but also planarization, surface smoothening, uniformity control, defect reduction and more. Moreover, semiconductor yield enhancement is sensitively influenced by CMP processing. Surface scratching, which is generated by CMP in nature, is considered as ‘killer defect’ in semiconductor manufacturing. Hence, to achieve proper CMP performance without surface scratching, understanding and development of abrasive particles are crucially important. In this chapter, CMP fundamentals, applications and challenges associated with abrasive particle technology including synthesis (up to nanoparticle scale), tribochemical reaction, abrasive surface zeta potential behavior, particle size and its distribution will be discussed.",book:{id:"6736",slug:"abrasive-technology-characteristics-and-applications",title:"Abrasive Technology",fullTitle:"Abrasive Technology - Characteristics and Applications"},signatures:"Hong Jin Kim",authors:[{id:"235449",title:"Dr.",name:"Hong Jin",middleName:null,surname:"Kim",slug:"hong-jin-kim",fullName:"Hong Jin Kim"}]},{id:"68532",title:"Application of the Fourth Industrial Revolution for High Volume Production in the Rail Car Industry",slug:"application-of-the-fourth-industrial-revolution-for-high-volume-production-in-the-rail-car-industry",totalDownloads:1037,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Some recent technological advances in line with the fourth industrial revolution (4IR) are rapidly transforming the industrial sector. This work explores the prospect of robotic and additive manufacturing solutions for mass production in the rail industry. It proposes a dual arm, 12-axis welding robot with advance sensors, camera, and algorithm as well as intelligent control system. The computer-aided design (CAD) of the robotic system was done in the Solidworks 2017 environment and simulated using the adaptive neuro-fuzzy interference system (ANFIS) in order to determine the kinematic motion of the robotic arm and the angles of joint. The simulation results showed the smooth motion of the robot and its suitability to carry out the welding operations for mass production of components during rail car manufacturing. In addition, the ability to fabricate several physical models directly from digital data through additive manufacturing (AM) is a key factor to ensuring rapid product development cycle. Given that AM is embedded in a digitally connected environment, flow of information as well as data processing and transmission in real time will be useful for massive turnout during mass production.",book:{id:"9278",slug:"mass-production-processes",title:"Mass Production Processes",fullTitle:"Mass Production Processes"},signatures:"Daniyan Ilesanmi, Oyesola Moses, Mpofu Khumbulani and Nwankwo Samuel",authors:[{id:"11921",title:"Prof.",name:"Khumbulani",middleName:null,surname:"Mpofu",slug:"khumbulani-mpofu",fullName:"Khumbulani Mpofu"},{id:"260269",title:"Dr.",name:"Ilesanmi Afolabi",middleName:null,surname:"Daniyan",slug:"ilesanmi-afolabi-daniyan",fullName:"Ilesanmi Afolabi Daniyan"},{id:"308892",title:"Mr.",name:"Moses",middleName:null,surname:"Oyesola",slug:"moses-oyesola",fullName:"Moses Oyesola"},{id:"308893",title:"Mr.",name:"Samuel",middleName:null,surname:"Nwankwo",slug:"samuel-nwankwo",fullName:"Samuel Nwankwo"}]},{id:"72044",title:"Applications of Machine Learning in Healthcare",slug:"applications-of-machine-learning-in-healthcare",totalDownloads:1034,totalCrossrefCites:5,totalDimensionsCites:5,abstract:"Machine learning techniques in healthcare use the increasing amount of health data provided by the Internet of Things to improve patient outcomes. These techniques provide promising applications as well as significant challenges. The three main areas machine learning is applied to include medical imaging, natural language processing of medical documents, and genetic information. Many of these areas focus on diagnosis, detection, and prediction. A large infrastructure of medical devices currently generates data but a supporting infrastructure is oftentimes not in place to effectively utilize such data. The many different forms medical information exist in also creates some challenges in data formatting and can increase noise. We examine a brief history of machine learning, some basic knowledge regarding the techniques, and the current state of this technology in healthcare.",book:{id:"10150",slug:"smart-manufacturing-when-artificial-intelligence-meets-the-internet-of-things",title:"Smart Manufacturing",fullTitle:"Smart Manufacturing - When Artificial Intelligence Meets the Internet of Things"},signatures:"Christopher Toh and James P. Brody",authors:[{id:"313941",title:"Ph.D. Student",name:"Christopher",middleName:null,surname:"Toh",slug:"christopher-toh",fullName:"Christopher Toh"},{id:"314005",title:"Dr.",name:"James",middleName:null,surname:"Brody",slug:"james-brody",fullName:"James Brody"}]},{id:"64172",title:"Application of Six Sigma in Semiconductor Manufacturing: A Case Study in Yield Improvement",slug:"application-of-six-sigma-in-semiconductor-manufacturing-a-case-study-in-yield-improvement",totalDownloads:1876,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"The purpose of this chapter is to outline systematic implementation of the Six Sigma DMAIC methodology as a case study in solving the problem of poor wafer yields in semiconductor manufacturing. The chapter also describes well-known industry standard business processes to be implemented and benchmarked in a semiconductor wafer fabrication facility to manage defect and yield issues while executing a Six Sigma project. The execution of Six Sigma enabled identification of the key process factors, root cause analysis, desired performance levels, and Cpk improvement opportunities. Implementing multilevel factorial design of experiments (DOE) study revealed critical input parameters on process tools contributing to defect formation. Improvement performed on these process tools resulted in in-line defect reduction and ultimately improving final yields.",book:{id:"7460",slug:"applications-of-design-for-manufacturing-and-assembly",title:"Applications of Design for Manufacturing and Assembly",fullTitle:"Applications of Design for Manufacturing and Assembly"},signatures:"Prashant Reddy Gangidi",authors:[{id:"248796",title:"Mr.",name:"Prashant",middleName:null,surname:"Gangidi",slug:"prashant-gangidi",fullName:"Prashant Gangidi"}]}],onlineFirstChaptersFilter:{topicId:"1356",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"July 20th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:14,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",institutionString:"Kafkas University",institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. 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He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Prosthodontics and Implant Dentistry",value:2,count:4},{group:"subseries",caption:"Oral Health",value:1,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:5},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}}]}},subseries:{item:{id:"19",type:"subseries",title:"Animal Science",keywords:"Animal Science, Animal Biology, Wildlife Species, Domesticated Animals",scope:"The Animal Science topic welcomes research on captive and wildlife species, including domesticated animals. The research resented can consist of primary studies on various animal biology fields such as genetics, nutrition, behavior, welfare, and animal production, to name a few. 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