Substrates, enzymes, and products of the shikimate pathway.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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The secondary pathways are not necessary for the survival of individual cells but benefit the plant as a whole [1]. Another general characteristic of secondary metabolism is that found in a specific organism, or groups of organisms, and is an expression of the individuality of species [2]. The secondary metabolism provides chemical diversity to organic molecules with low molecular weight that are related by the respective pathways; such organic molecules are called secondary metabolites. The secondary metabolites are often less than 1% of the total carbon in plant molecules [3]. These organic molecules isolated from terrestrial plants are the most studied, and their syntheses have an important role in the protection against pathogens, unfavorable temperature and pH, saline stress, heavy metal stress, and UVB and UVA radiation [3]. Secondary metabolism reflects plant environments more closely than primary metabolism [4]. There are three principal kinds of secondary metabolites biosynthesized by plants: phenolic compounds, terpenoids/isoprenoids, and alkaloids and glucosinolates (nitrogen- or sulfur-containing molecules, respectively) [5]. Phenolic compounds are biosynthesized by the shikimate pathway and are abundant in plants. The shikimate pathway, in plants, is localized in the chloroplast. These aromatic molecules have important roles, as pigments, antioxidants, signaling agents, electron transport, communication, the structural element lignan, and as a defense mechanism [6], Figure 1. The seven steps of the shikimate pathway and the metabolites for branch point are described in this chapter, as factors that induce the synthesis of phenolic compounds in plants. Some representative examples that show the effect of biotic and abiotic stress on the production of phenolic compounds in plants are discussed.
\nPhenolic compound biosynthesis promoted by biotic and abiotic stresses (e.g., herbivores, pathogens, unfavorable temperature and pH, saline stress, CO2, O3, heavy metal stress, and UVB and UVA radiation).
The shikimate biosynthesis pathway provides precursors for aromatic molecules in bacteria, fungi, apicomplexan, and plants, but not in animals [2, 7]. Shikimic acid is named after the highly toxic Japanese
The shikimic and chorismic acids are the common precursors for the synthesis of L-Phe, L-Tyr, and L-Trp and diverse phenolic compounds.
The shikimate pathway consists of seven sequential enzymatic steps and begins with an aldol-type condensation of two phosphorylated active compounds, the phosphoenolpyruvic acid (PEP), from the glycolytic pathway, and the carbohydrate D-erythrose-4-phosphate, from the pentose phosphate cycle, to give 3-deoxy-D-
Shikimate pathway.
Reaction step | \nSubstrate | \nEnzyme/cofactor | \nProduct | \n
---|---|---|---|
1 | \nPhosphoenolpyruvate (PEP), erythrose-4-phosphate | \n3-Deoxy-D- | \n3-Deoxy-D- | \n
2 | \n3-Deoxy-D- | \n3-Dehydroquinate synthase DHQS (EC. 4.2.3.4)/Co2+, NAD+ [15, 16] | \n3-Dehydroquinic acid (DHQ), Pi | \n
3 | \n3-Dehydroquinic acid (DHQ) | \n3-Dehydroquinate dehydratase (DHQ dehydratase EC 4.2.1.10) [15] | \n3-Dehydroshikimic acid (DHS), H2O | \n
4 | \n3-Dehydroshikimic acid (DHS), NADPH + H+ | \nShikimate dehydrogenase (SDH; EC 1.1.1.25) [18, 19, 20, 21] | \nShikimic acid, NADP+ | \n
5 | \nShikimic acid, ATP | \nShikimate kinase enzyme (SK; EC 2.7.1.71) | \nShikimic acid 3-phosphate (S3P), ADP | \n
6 | \nShikimic acid 3-phosphate (S3P), PEP | \n5- | \n5- | \n
7 | \n5- | \nChorismate synthase (CS; EC 4.2.3.5)/FMNH2 [2, 19, 30, 31] | \nChorismic acid, Pi | \n
Substrates, enzymes, and products of the shikimate pathway.
Pi, phosphate; NAD+, oxidized nicotinamide adenine dinucleotide; NADPH, reduced nicotinamide adenine dinucleotide phosphate; FMNH2, reduced flavin mononucleotide.
The shikimate pathway has special characteristics that are present only in bacteria, fungi, and plants. The absence of the pathway in all other organisms provides the enzymes catalyzing these reactions with potentially useful targets for the development of antibacterial agents and herbicides. For example, 5-
In the second reaction step, DAHP loses phosphate (Pi); the enolic-type product is cyclized through a second aldol-type reaction to produce 3-dehydroquinic acid (DHQ). The 3-dehydroquinate synthase (DHQS) catalyzes this cyclization in the shikimate pathway. The DHQ dehydrates to produce 3-dehydroshikimic acid (DHS) (3-dehydroquinate dehydratase); this compound has a conjugated double carbon-carbon, Figure 3. The protocatechuic and the gallic acids (C6-C1) are produced by branch-point reactions from DHS [2]. The fourth step in the pathway is a reduction reaction of DHS with reduced nicotinamide adenine dinucleotide phosphate (NADPH), Figure 3. The fifth section of the pathway is the activation of shikimic acid with adenosine triphosphate (ATP) (shikimate kinase, SK) to make shikimic acid 3-phosphate (S3P). The sixth chemical reaction is the addition of PEP to S3P to generate 5-
PEP and glyphosate (powerful inhibitor of the 5-enolpyruvylshikimate 3-phosphate synthase, EPSPS).
The last reaction step of the shikimate pathway is the production of chorismic acid from catalytic action on the chorismate synthase (CS). This reaction is a 1,4-
The first reaction of the shikimate pathway is an aldol-type condensation of PEP and carbohydrate erythrose-4-P, to give 3-deoxy-D-
Stereochemistry of the condensation reaction of (
The second reaction of the shikimate pathway is an intramolecular aldol-type reaction cyclization, where the enol (C6-C7) of DAHP nucleophilically attacks the carbonyl group (C2), to produce a six-member cycle, the 3-dehydroquinic acid (DHQ), Figures 3 and 6. The enzyme that catalyzes this reaction, 3-dehydroquinate synthase DHQS (EC. 4.2.3.4), is a carbon-oxygen lyase enzyme that requires Co2+ and bound oxidized nicotinamide adenine dinucleotide (NAD+) as cofactors [15, 16]. The Co2+ is essential for the catalytic activity of DHQS. Bender et al. [16] found that DHQS, from
Reaction mechanism of DAHP (hemiketal form) to 3-dehydroquinic acid (DHQ) by 3-dehydroquinate synthase DHQS (EC. 4.2.3.4) [
The reduction reaction of DHQ leads to quinic acid at this branch point in the shikimate pathway. Quinic acid is a secondary metabolite that is free, forming esters or as part of alkaloids such as quinine. Quinic acid is found in high quantities in mature kiwi fruit (
The third and fourth reaction steps of the shikimate pathway are catalyzed by a bifunctional enzyme: 3-dehydroquinate dehydratase/shikimate dehydrogenase (DHQ dehydratase/SDH; EC 4.2.1.10/EC 1.1.1.25). The DHQ dehydratase enzyme is a hydro-lyase kind, and the SDH is an oxidoreductase enzyme. The DHQ dehydratase, in the third reaction step, converts DHQ into 3-dehydroshikimic acid (DHS) by eliminating water, and this reaction is reversible, Figure 7. The DHS is converted to shikimic acid in the fourth reaction step, by the reduction of the carbonyl group at C-5 by the catalytic action of SDH with NADPH, Figure 3. The biosynthesis of DHS is a branch point to shikimic acid and to the catabolic quinate pathway. If the DHS dehydrates, it produces protocatechuic acid (C6-C1) or gallic acid, Figure 3. Gallic acid (C6-C1) is a hydroxybenzoic acid that is a component of tannins [2].
\nReaction mechanism to produce 3-dehydroshikimic acid (DHS) by type I DHQ dehydratase enzyme [
Two structurally different kinds of 3-dehydroquinate dehydratase are known: type I (not heat-stable) and type II (heat-stable). Type I enzyme is present in bacteria and higher plants, and type II is found in fungi, which have both types of enzymes [18, 19]. The catalytic mechanism of the type I DHQ dehydratase has been detected by electrospray MS [20]. This catalytic mechanism involves the amino acid residue Lys-241 that forms a Schiff base with the substrate and product, Figure 7 [21]. The fourth step is the reduction of DHS with NADPH that enantioselectively reduces the carbonyl of the ketone group of DHS to produce shikimic acid (shikimate dehydrogenase, SDH), Figure 3.
\nSigh and Christendat [22] reported the crystal structure of DHQ dehydratase/SDH from the plant genus
The shikimate kinase enzyme (SK; EC 2.7.1.71) catalyzes the phosphorylation of the shikimic acid, the fifth chemical reaction of the shikimate pathway, and the products are shikimic acid 3-phosphate (S3P) and ADP, Figures 3 and 8. Shikimic acid is phosphorylated with ATP in the 5-hydroxyl group of shikimic acid. SK is an essential enzyme in several bacterial pathogens and is not present in the human cell; therefore the SK enzyme has been classified as a protein target for drug design, especially for chemotherapeutic development of antitubercular drugs [23, 24].
\nPhosphorylation of shikimic acid with ATP.
The 5-
Reaction mechanism of the condensation of S3P with PEP by EPSPS (EC 2.5.1.19) to form EPSP [
EPSPS is the most studied enzyme of the shikimate pathway because it plays a crucial role in the penultimate step. If this enzyme is inhibited, there is an accumulation of shikimic acid [26], and the synthesis of aromatic amino acid is disabled, leading to the death of the plant [27]. Therefore, EPSPS is used as a target for pesticides, like glyphosate, Figure 4, the active ingredient in the herbicides RoundUp™, Monsanto Chemical Co., and Touchdown™, Syngenta. Glyphosate (
The seventh and last reaction step of the shikimate pathway is the 1,4-
Reaction of mechanism to yield chorismic acid by chorismate synthase [
The expression of phenolic compounds is promoted by biotic and abiotic stresses (e.g., herbivores, pathogens, unfavorable temperature and pH, saline stress, heavy metal stress, and UVB and UVA radiation). UV radiation is divided into UVC (≤280 nm), UVB (280–320 nm), and UVA (300–400 nm). UVA and UVB radiation are transmitted through the atmosphere; all UVC and some UVB radiation (highly energetic) are absorbed by the Earth’s ozone layer. This accumulation is explained by the increase in enzymatic activity of the phenylalanine ammonia-lyase and chalcone synthase enzymes, among others [12]. Studies have been done about the increase of phenolic compounds, such as anthocyanins, in plants when they are exposed to UVB radiation [13]. Another study demonstrates that UVB exposure enhances anthocyanin biosynthesis in “Cripps pink” apples (
The increase in phenolic compounds in blueberry (
Chemical structure of chlorogenic (C6-C3) and ellagic (C6-C1) acids.
An interesting study was carried out in 2011 by Mody et al., where they studied the effect of the resistance response of apple tree seedlings (
Chemical structure of phlorizin (C6-C3).
Knowledge of the biosynthetic pathway of shikimic acid leads to understanding the reaction mechanisms of enzymes and thus discovering antimicrobials, pesticides, and antifungals. Studies with isotopic labeling of substrates, the use of X-ray diffraction, nuclear magnetic resonance (NMR), mass spectrometry (ES), biotechnology, as well as organic synthesis have contributed to explaining the shikimate pathway. Although the seven steps of the biosynthetic pathway are elucidated, these metabolites are the precursors of phenolic compounds, more complex molecules that are necessary for the adaptation of plants to the environment. So, the shikimate pathway is the basis for the subsequent biosynthesis of phenolic compounds. There is scientific interest in continuing to investigate the biosynthesis of phenolic compounds from several points of view: pharmaceuticals, agronomy, chemical and food industries, genetics, and health.
\nThe authors thank Carol Ann Hayenga for her English assistance in the preparation of this manuscript. The Technological University of the Mixteca provided support.
\nThe authors have no conflict of interest to declare and are responsible for the content and writing of the manuscript.
This chapter does not contain any studies with human participants or animals performed by any of the authors.
\nAir pollution causes serious damage to human health and the environment. The World Health Organization reported that 9 out of every 10 people in the world breathe polluted air and 7 million people lost their lives due to air pollution [1]. Harmful gases, which are released from industrial facilities, power plants, automobiles and other transport vehicles, threaten human health by entering the airways, the lungs and the bloodstream from there. In addition to human health, biodiversity and ecosystems are also endangered by air pollution. The damages of air pollution at financial level reach very serious figures [2]. It is reported that in 2015, air pollution caused USD 280 billion expense only in social assistance costs worldwide [3]. From past to present, dozens of reports on air pollution and its effects have been published by various organizations, and various policies and plans have been drafted and regulations and laws have been enacted in order to prevent air pollution [4, 5, 6, 7, 8, 9, 10].
\nNOx emissions are one of the most important pollutants causing air pollution and climatic change. NOx emissions are in the most effective pollutant class with PM and ozone (O3) [8]. All kinds of sources where combustion is performed at high temperatures (internal combustion engines, gas turbines, power plants, industry etc.) create NOx emissions and 95% of NOx emission is made by these sources [4].
\nNOx emissions are called nitrogen oxides and are usually in the form of nitrogen monoxide (NO) and nitrogen dioxide (NO2). NO emission is a colorless and odorless gas and poisonous to humans. NO2 gas is a highly reactive gas in red-brown color and has a suffocating odor and high oxidizing property. Compared with NO gas, the toxic effect of NO2 gases is 5 times higher [11, 12].
\nThe effects of NOx emissions on human health are on a frightening scale. Today, pollutant emissions and especially NOx emissions lie behind the problems, which about many individuals complain. The report of the European Environment Agency (EEA), published in 2017, shows the extent of the air pollution and the threat of global warming caused by NOx emissions. It is stated in this report that NOx emissions in 2014 caused about 80,000 premature deaths in Europe [8].
\nThe effects of NOx gases on human health are directly proportionate to the density and inhalation period. Low rates or short-term inhalation of NOx emissions can cause health problems such as eye and throat irritation, chest tightness, nausea, headache and loss of strength. Long-term or large amount of exposure to NOx gases causes severe coughing, difficulty in breathing, asthma, cyanosis, and sometimes give rise to even death [13]. The World Health Organization (WHO) states that 80% of lung diseases and lung cancer are caused by air pollution, particularly by NOx [9]. A study found that NOx emissions causes premature birth resulting from asthma in pregnant women [14].
\nNOx pollutant emissions also play an important role in ground-level ozone formation, which has serious adverse effects on human health and the environment. In the natural process, ozone (O3) is a very reactive form of oxygen formed in the upper layer of the atmosphere and protects the earth from the sun’s ultraviolet rays. However, the ozone layer that takes place due to the pollutant emissions under the atmosphere is very dangerous. When NO emissions are released into the air, they react with O2 in the air and form NO2 and cause formation of undesirable ground-level ozone. Ozone formed in this way leads to global warming, causing serious damage to human health and environment [15].
\nGround-level ozone formation, which is caused by NOx emissions, invites global warming by increasing the greenhouse effect. Due to the undesirable ozone formation, the year 2015 has been the hottest year since the past [8].
\nFigure 1 shows the effect of NOx emissions on ozone and greenhouse gases. The rays coming on the Earth are reflected by the earth and are absorbed by the gases (mainly carbon dioxide (CO2), methane (CH4) and water vapor) in the atmosphere. This natural process called the greenhouse effect give rise earth to warm. The presence of redundant gases in the atmosphere causes the reflected radiation to be held at a high level, resulting increase in warming and temperatures than the normal level in the earth. The activity of the people, especially the emissions of NOx pollutants formed from the consumption of fossil fuels, cause the greenhouse effect to intensify by increasing the amount of greenhouse gases. The formation of greenhouse gases more than normal in the atmosphere, brings with it climate change and global warming.
\nOzone & ground level ozone and greenhouse effect.
Rain is very effective in removing NO2 gases from the atmosphere. However, the contact of NO2 gas with water produces nitrous acid (HNO2) and nitric acid (HNO3), which have a very corrosive effect (Figure 2). This leads to acid rain, which is harmful particularly for plants. In addition to acid rain, the combination of NO2 emissions with hydrocarbon (HC) emissions leads to the formation of photochemical smog.
\nThe formation of acid rains.
Many precautions are taken by various organizations to reduce the negative effects of NOx emissions on human health and the environment, and various policies and laws are being established. In 2030, if severe climatic policies are implemented, two-thirds of the NOx emissions in 2005 will be reduced [16]. Creation of clean air zones, establishment of emissions standards by various organizations, taking necessary measures to eliminate pollutant emissions are among the policies that developed to prevent NOx emissions. Significant work is being done around the world to remove old model vehicles which are far from emissions standards, and which cause high levels of pollutant emissions and leading to serious environmental and human health problems. As a result of established policies and measures taken, in many countries, NOx emissions and other pollutant emissions have been significantly reduced compared to previous periods [7, 10, 17, 18, 19].
\nRoad transport takes place on the top among sources that bring on the formation of NOx emissions. Due to its high efficiency and low fuel consumption, diesel engines with a wide range of applications in the transportation sector lead a high rate of NOx emission. Diesel vehicles play an important role in the formation of NOx emissions causing air pollution.
\nThere are three different mechanisms of NOx formation in diesel engines, prompt NOx, fuel NOx and thermal NOx. Prompt NOx formation occurs because of rapid reactions between the nitrogen, oxygen and hydrocarbon radicals. In case of the presence of nitrogen content in the fuel, the nitrogen contained in the fuel reacts with oxygen and this mechanism defined as fuel NOx. In the thermal NOx mechanism, nitrogen and oxygen react at high temperatures and cause NOx formation [20].
\nThe thermal NOx mechanism is generally seen as the main source of NOx formation in diesel engines. The Zeldovich model given below explains this mechanism.
\nThe NO emissions resulting from the reaction (1)–(3) can be converted to NO2 or back to NO form with the following reactions.
\nTemperature and oxygen content are the two basic parameters affected the thermal NOx mechanism. Diesel engines are operated with lean mixtures that had high air excess coefficients. Thus, the combustion process involves more oxygen than necessary. On the other hand, the high compression ratios of diesel engines create high combustion end temperatures in combustion chamber. Therefore, diesel engines offer a very effective infrastructure for the formation of NOx emissions. Compression ratio and air excess coefficient values of diesel engines are considerably higher than those of gasoline engines. In this case, when compared with gasoline engines, diesel engines causes the generation of NOx emissions at much higher rates.
\nWhen cylinder temperature exceeds about 1500°C, N2 gas in the air taken into the cylinder reacts with oxygen to form NOx [21]. Depending on the increase in temperature, NOx also increase. Each increase of 1% in temperature over 1700°C causes 20% increase in NOx [22].
\nBesides the combustion end temperature, thermodynamic conditions, combustion reaction, flame speed and the time that the burned gases exposed to high temperature are the main parameters affected the formation of NOx emissions. All kinds of engine specifications, which have an effect on these parameters, play an effective role in the formation of NOx. Some of these specifications include compression ratio, injection system, injection timing, combustion chamber geometry, air excess coefficient, engine speed and fuel composition.
\nThe air excess coefficient, which is the function of the amount of oxygen present in the cylinder, is obtained by dividing the actual air/fuel ratio received into the cylinder to the theoretical air/fuel ratio required to burn a unit fuel. The air excess coefficient is denoted by the symbol λ. When λ is bigger than 1, it means that the mixture inside the cylinder is lean and when it is smaller than 1, it means that the mixture inside the cylinder is rich and when it is equal to 1, it means that it is the stoichiometric ratio. When λ is around 1.1, maximum NOx formation occurs. As the air/fuel ratio increases above 1.1 and the mixture becomes leaner, the cylinder temperature decreases and NOx emissions decrease.
\nIn diesel engines, a large majority (80–85%) of NOx emissions formed as a result of combustion are in NO form. Almost all of the NOx emissions occur during 20 CAD (Crank Angle Degree) following the start of combustion [23].
\nThe fact that diesel-powered vehicles have more widespread use due to their superiority over gasoline-powered vehicles and the ever-increasing number of diesel-powered vehicles leads to a significant increase in NOx emissions released to the environment.
\nFigure 3 presents the Euro Standards of NOx emission for heavy-duty vehicles. The European Union first introduced euro standards for heavy-duty vehicles in 1993 to reduce the damages of NOx emissions from diesel vehicles on human health and environment.
\nEuro standards of NOx emission for heavy-duty vehicles [
The amount of NOx applicable to heavy-duty vehicles under Euro VI standards, which has been in effect since 2013, has been reduced to 0.4 g/kWh. This value is exactly 92% lower compared to the Euro III standard which was implemented in 2001. It is aimed to reduce the amount of NOx to below 0.1 g/kWh in 2023.
\nMany research and development activities are carried out scientifically or commercially to eliminate NOx emissions from diesel engines. Developed methods for reducing NOx emissions in these activities are divided into pre-treatment and after-treatment methods. Reducing of NOx emissions before directing to the exhaust port of the engine is called pre-treatment method and reducing of NOx emissions after directing to the exhaust port of engine is called after-treatment method. Exhaust Gas Recirculation (EGR), electronically controlled fuel injection, engine modification, increasing injection timing, water spray in the combustion chamber, improvement of fuel properties, use of fuel additives, etc. are pre-treatment methods of reducing NOx emissions. Lean NOx trap (LNT) catalysts and the Selective Catalytic Reduction System are the examples of after treatment methods. This study focuses on Exhaust Gas Recirculation (EGR), Lean NOx trap (LNT) catalysts and Selective Catalytic Reduction (SCR) systems, which have been developed to prevent NOx emissions and which are widely used in diesel engines. Since they are the most effective methods for eliminating NOx emissions, these three systems are focused on. Each NOx emission control system is addressed in detail in the light of current information.
\nEGR is a system developed to incorporate some of the exhaust gases in the cylinder into the combustion process with the intake air. The purpose here is to lower the combustion end temperature and thus the NOx emission values by deteriorating the combustion performance, because high temperature is the main influence in the formation of NOx emissions. The use of the EGR system reduces the amount of oxygen in the cylinder, and therefore resulting in a decrease in the combustion end pressure and temperature. The decrease in the amount of oxygen suppresses the formation of NOx. The exhaust gas recirculated in the cylinder and containing large amounts of CO2 and H2O increases the specific heat capacity of the intake charge, and this reduces the temperature values in the compression and combustion processes [25]. Displacement of some of the oxygen content in the intake charge by the exiting exhaust gases reduces the air excess coefficient and increases the ignition delay by diluting the intake charge. This slows the mixture of oxygen with fuel and therefore the combustion rate.
\nThe EGR system developed to reduce the combustion end temperature in the cylinder has been widely used by automobile manufacturers since the past. The circulation of the exhaust gas with the intake air can be achieved in two different ways; external and internal [26]. In the external exhaust gas recirculation, the exhaust gas taken from the exhaust manifold is sent to the intake stream through a valve and a coolant. In the internal exhaust gas recirculation, unlike the external exhaust gas recirculation, some of the combustion exhaust gas is withdrawn to the combustion chamber before exiting the exhaust valve. This is accomplished by delaying the camshaft and closing the exhaust valves a little later than normal. The late closing of the exhaust valve allows the piston to draw a portion of the exhaust gas at the outlet of the exhaust valve into the cylinder while the piston is moving downward at intake stroke. The engines, which have the internal EGR systems, are run with variable valve timing. Compared with external EGR, the internal EGR system remains weak in controlling exhaust gas into the cylinder. In addition, since no cooling operation can be performed on the recirculated exhaust gas, desired reductions in NOx emission values are not achieved. The internal EGR system is generally preferred for gasoline engines, which have lower NOx emissions compared to diesel engines. On the other hand, external EGR systems are widely used in diesel engines.
\nFigure 4 shows the structure of a conventional EGR system used in diesel engines. The system simply consists of valve, control unit and coolant. The EGR valve mounted on the intake manifold is controlled by the control unit. The function of the EGR valve is to control the flow of exhaust gas to intake port depending on the engine load. The amount of exhaust gas sent to the intake port may constitute a maximum of 50% of the air taken into the combustion chamber [27]. Because of the high exhaust gas content included in the combustion, the combustion performance is greatly affected; therefore the engine performance can decrease significantly. For this reason, the exhaust gas content mixed with the intake air does not exceed 20% in practice.
\nExhaust gas recirculation (EGR).
The cooling of the exhaust gas included in the combustion process in the EGR system allows the higher amount of exhaust gas to be included in the combustion process and at the same time the combustion chamber temperature and hence NOx emissions can be further reduced. For this reason, in the EGR systems, the exhaust gas is passed through a cooler and sent to the intake stream. Cooling is carried out using engine coolant. In an electronically controlled cooling system, the cooling process is optimized depending on different engine loads, temperatures and conditions.
\nIn turbocharged diesel engines, the use of EGR takes place in two different ways; high pressure and low pressure. In a high-pressure EGR system, the exhaust gas is recirculated to the intake channel before the exhaust gas goes to the turbine and in the low-pressure EGR system the exhaust gas is recirculated after passing through the turbine.
\nThanks to the EGR system, the NOx emission in diesel engines can be reduced by up to 50% [26]. However, in this method, combustion is worsened, engine performance decreases, and other pollutants, especially particulate emissions (PM) slightly increases. At the same time, the EGR system leads to an increase of about 2% in fuel consumption [28]. Due to the flow of the exhaust gas, EGR system can affect the quality of lubrication oil and the engine durability negatively, and erosion on piston rings and cylinder liner can increase [29]. These disadvantages and developed aftertreatment emission control technologies have overshadowed the EGR system [30].
\nLean NOx trap (LNT) technology, also referred to as NOx absorber catalyst (NAC), NOx storage catalyst (NSC) or NOx storage/reduction (NSR) catalyst, is a method used to convert NOx emissions at particularly low exhaust gas temperatures. At low exhaust gas temperatures, NOx emissions in the exhaust gas content are absorbed at the catalyst surface and released when the exhaust temperature reaches high values.
\nCoating surface in LNT catalyst consists of an oxidation catalyst, an absorbent combined with alkali metals and a reduction catalyst. In LNT catalysts, there is usually Platinum and Rhodium supported by Al2O3 structure with component that has a NOx storage property such as barium carbonate (BaCO3). The reactions in the LNT catalyst occur in two different cycles; lean and rich. In the lean cycle, NO is absorbed into the storage component and converted to NO2 by being oxidizing on the catalyst surface and stored in the nitrate form on the surface. In the rich cycle, the stored NOx is released from the surface and converted to N2 on the catalyst surface via CO, HC and H2, which are formed due to incomplete combustion. All of the reactions taking place in the LNT catalyst are given in Eqs. (6)–(11).
\nIn Eq. (6), NO emissions at low exhaust gas temperatures are oxidized on the Platinum catalyst and converted to NO2 form. NO2 emissions are then absorbed in the Barium nitrate form, which has a storage feature of NOx emissions (Eq. (7)). When the storage capacity is full, regeneration is started by increasing the exhaust gas temperature to high levels. During the regeneration process, the stored nitrogen compounds become thermodynamically unstable and decomposed into NO and NO2 forms (Eqs. (8) and (9)). In the presence of CO, HC and H2, the released NO and NO2 components are then reacted on catalyst to form N2.
\nIncreasing the exhaust gas temperature for regeneration in LNT systems can be achieved by injecting extra diesel fuel or hydrogen into the cylinder. Since diesel engines have lean mixture, HC is included externally by being injected into the exhaust gas. In the LNT technology, the amount of injected fuel, injecting timing and the ability of the catalyst to store NOx are parameters that must be optimized to ensure fuel economy.
\nAlthough LNT technology is a suitable solution for NOx conversion at low exhaust gas temperatures, it has some disadvantages. LNT catalysts usually contain precious metals such as Pt at high level to increase the oxidation process of NO emissions and to ensure their continuity. However, this situation increases the cost. At the same time, LNT catalysts need the supply of NO2 with NO oxidation to provide storage. For this reason, they do not have high NOx storage efficiency at exhaust gas temperatures below 150°C. On the other hand, Nitrates (NO3) formed as a result of storage are highly stable and they need to be decomposed in rich operating conditions for reacting of NOx emissions with reductants such as HC, CO and H2 on the catalyst surface to form N2. This affects the fuel economy negatively, and undesirable increases can happen in CO, HC and PM emissions. In the LNT catalysis, NOx adsorption can be poisoned by sulfur compounds and this undesirable sulfur poisoning causes the catalyst to lose its properties. Sulfur poisoning can be removed by desulphurization at exhaust gas temperatures of 600–750°C. This increases fuel consumption and other pollutant emissions. The use of low sulfur diesel fuel (ULSD) reduces sulfur poisoning and the frequency of desulphurization. To overcome these disadvantages of LNT catalysts, different catalyst types such as Ce, Paladium and different methods have been investigated [31].
\nLNT technology has a wide range commercial application worldwide. Yang et al. [30] indicated that the LNT technology was adapted to more than half a million vehicles by many manufacturers, including VW and BMW. Up to 90% conversion efficiency at the low engine loads and its combination with the SCR system has raised the use of LNT technology in market.
\nThe selective catalytic reduction of NOx emissions was dates back to 1970s but was used commercially in heavy-duty vehicles in 2005 [32, 33]. In the selective catalytic reduction process, NOx emissions in the exhaust gas are converted to N2 and H2O via a reducing agent. NH3-SCR and HC-SCR systems, where NOx emissions are eliminated by the use of ammonia and hydrocarbons, are the most widely used technologies.
\nIn SCR systems, ammonia (NH3) which is generally highly efficient is used as reducer. Ammonia is obtained from aqueous urea solution called AdBlue in the market to prevent burning due to high exhaust gas temperatures. The aqueous urea solution consists of 67% purified water (H2O) and 33% urea solution ((NH2)2CO). Aqueous urea solution (AdBlue) is the most commonly used reductant in SCR systems. Particularly at high exhaust gas temperatures (350–450°C), NOx emissions in exhaust gas can be eliminated at high rates using AdBlue [34]. However, at low exhaust gas temperatures below 200°C, the conversion efficiency is underperforming and ammonia accumulates on the exhaust line and the catalyst surfaces. Temperatures above 600°C are a major problem for the NH3-SCR system. Because high temperatures can cause the reductant to burn before reaching the catalyst, and at the same time cause catalyst deformation. The active operating range of the NH3-SCR system is between 200 and 600°C exhaust gas temperatures. A maximum conversion efficiency can be achieved about 350°C [35].
\nFigure 5 visually shows the reactions that occur when the aqueous urea solution is sprayed onto the exhaust gas.
\nNOx conversion reactions in NH3-SCR.
In NH3-SCR system, the aqueous urea solution sprayed on the exhaust gas is first subjected to thermolysis and hydrolysis reactions under the influence of high temperature (Eqs. (12) and (13)). These reactions result in the production of two molecules of ammonia from one molecule urea.
\nThe main reactions occurring in the system after the thermolysis and hydrolysis reactions are given in Eqs. (14)–(16).
\nEq. (14) provides the highest conversion efficiency in the conversion reactions taking place in the NH3-SCR system. This reaction usually takes place when a diesel oxidation catalyst (DOC) is present before the NH3-SCR system. DOC converts NO emissions to NO2 form and when the content of NO and NO2 in the exhaust gas get close to each other, higher efficiency is achieved in the NH3-SCR system. Therefore, NH3-SCR system usually needs DOC and they are used together in applications. Eq. (15) occurs when there isn’t any DOC before the NH3-SCR system and NO emissions are included with large amount in the exhaust exit. If the DOC catalyst is larger than the necessary and consequently the vast majority of NO emissions are converted to NO2, the Eq. (16) is realized. In terms of efficiency, this equation exhibits the worst conversion performance [36].
\nFigure 6 presents a schematic view of a classical NH3-SCR system. In this system managed by an electronic control unit, the data from the NOx and temperature sensors is evaluated and injector sprays the reductant with an optimized rate onto the exhaust gas.
\nNH3-SCR system.
Thanks to the NH3-SCR system, diesel engines can be operated at high combustion end temperatures, thus resulting in improved engine performance and fuel consumption. With the use of the NH3-SCR system, fuel consumption can be reduced by 5% [37].
\nMetal oxides and zeolites are the most commonly used catalyst types in NH3-SCR systems. Metal oxide catalysts are a group of catalysts produced from metals such as vanadium and titanium (V2O5-WO3/TiO2), which operate efficiently generally between 250 and 400°C [38]. When compared to metal oxide catalysts, zeolite catalysts are capable of operating in the high temperature range of 400–550°C [39]. While V2O5-WO3/TiO2 catalysts were preferred for commercial use of NH3-SCR in the vehicles in 2005, Fe-zeolites began to be used more widespread in the period after 2010 [40]. In addition to these catalysts, Cu-ZSM5 and Ag/Al2O3 catalysts may be preferred in applications. In particular, Ag/Al2O3 catalysts can exhibit high performance at low exhaust temperatures.
\nCost, an extra storage that it requires and the space that it takes up on the vehicle are the biggest problem in using the NH3-SCR system. However, as a result of the studies performed in the NH3-SCR system, it is achieved that a volume reduction of 60%, a weight reduction of 40% and a cost reduction of 30% when compared to 2010 [41]. Low efficiency at low exhaust gas temperatures, ammonia slip, lifetime, adaptation to different operating conditions, integration with other oxidation and particulate filter systems are the negative aspects of NH3-SCR systems. In addition, the NH3-SCR system requires a pre-catalyst (DOC) because they exhibit the best performance while NO/NO2 ratio is 1.
\nEven if NH3-SCR system has been developed for heavy-duty vehicles in general, it is widely used in many automobiles thanks to innovations (electronic injection, etc.) in the system [42]. NH3-SCR is the most effective system to meet the NOx emission values determined by the organizations in the current situation [40]. In addition, the fuel consumption of engine improves with the use of NH3-SCR system.
\nWhen compared to NH3-SCR, HC-SCR systems have stayed in the background due to their low efficiency, but the catalysts in which hydrocarbons are used as reductant have been developed since 1980 [33].
\nAs an alternative to NH3 reductant in SCR systems, the use of HCs improves the performance of the SCR system at low temperature. The use of diesel fuel or unburned HCs in the exhaust stream simplifies the system and reduces the cost. In addition to diesel fuel, oxygen-containing HCs such as ethanol, methanol, and propanol are highly effective in NOx conversions [43].
\nThe NOx conversion reactions occurred in HC-SCR systems are given below.
\nHC-SCR system is an up-to-date field of study, where many researches has been made on. The studies have focused especially on the development of catalysts for HC-SCR systems. Ag/Al2O3 catalysts are the most preferred type of catalyst in HC-SCR systems. Besides, silver, gold, copper, platinum, rhodium, cobalt and iron-based zeolites are used as catalysts in HC-SCR systems [44].
\nIn the HC-SCR systems where conventional Ag-containing Al2 O3 structures are used as catalysts, NOx conversions exceeding 80% can be achieved in the temperature range of 350–500°C. At the same time, these structures are very resistant to the adverse effects of water and sulfur. It is even indicated that the sulfur formation on the silver catalyst enhances the conversion efficiency [45]. In Ag-containing catalysts, hydrogen accelerates the oxidation of HC, thereby increasing NOx conversion efficiency. In addition, the use of hydrogen increases NOx conversion efficiency at low temperatures by retaining radicals in reducing NOx emissions [46].
\nThe conversion efficiency of NOx emissions in HC-SCR systems varies depending on the HC and NOx ratio in the exhaust gas content. That the amount HC is 2–4 times higher than NOx emission can provide conversion in NOx emissions up to 80%. However, in diesel engines, the exhaust gas does not contain HC in this amount. Therefore, the amount of HC in the exhaust gas content must be provided by enriching the mixture during combustion or spraying it directly on the exhaust gas [47]. Direct injection of HC’s onto the exhaust gas can be controlled by different parameters via an injector and control unit. Increasing the amount of HC in the exhaust gas content by enriching the mixture in the engine is an indirect method and high NOx conversion efficiency cannot be obtained.
\nNOx emissions and the air pollution resulting from it are not the precepts of the countries. Establishing policies, making regulations, taking the necessary measures and making them sustainable for reducing pollutant emissions, especially NOx emissions in the world, will prevent air pollution and global warming and thus the world will become more liveable in terms of environment and human health.
\nAlthough diesel engines cause high level NOx emissions in the combustion stage, these harmful gases can be disposed of at very high rates by improving the emission control systems before and after the engine.
\nAlthough the EGR system which is one of the pre-engine emission control systems can provide up to 50% NOx conversion, it is inadequate to provide the desired emission values. In the present case, the desired reductions in NOx emissions can be achieved with post-engine emission control systems.
\nIn post-engine control systems, NOx emissions can be reduced in the desired level without any reduction in engine performance due to the catalysts used. LNT and SCR technologies are effective post-engine emission control systems used in NOx disposal.
\nIn LNT technology, NOx emissions absorbed at low exhaust temperatures are released at high exhaust gas temperatures and reacted with HC, CO and/or H2 and converted to nitrogen. LNT technology can especially provide suitable solutions for light duty vehicles. However, LNT systems doesn’t have high NOx storage capacity, it is highly susceptible to sulfur poisoning and it needs rich operating conditions for regeneration process. These problems restrict the efficiency of LNT system.
\nThanks to SCR technology, high conversion rates can be achieved in NOx emissions. Today, the SCR system is the most efficient of the post-engine emission control systems used to reduce NOx emissions. However, even though the SCR systems perform well at temperatures above 200°C, they do not perform well when the exhaust gas temperature is below 200°C during initial operation of engine. In SCR systems, performance at low exhaust gas temperatures can be avoided by an LNT catalyst used before the SCR system. LNT catalysts provide the conversion of NOx pollutants in SCR system by absorbing NOx emissions at low exhaust temperatures and releasing NOx emissions when the exhaust temperature reaches high levels. While the LNT catalyst has high NOx absorptive ability at low exhaust temperatures, NOx conversion performance of the SCR system is low. At high exhaust gas temperatures, while the LNT catalyst has low NOx absorptive ability, NOx conversion performance of the SCR system is high. For this reason, the two systems complement each other and NOx emissions can be controlled both at low exhaust gas temperatures and at high exhaust gas temperatures. With the combined use of SCR and LNT technologies, NOx emissions can be eliminated in all operating conditions.
\nIn the years to come, it is inevitable that emissions standards put into effect by various organizations for diesel vehicles will be further strict in order to prevent air pollution and global warming caused by it. In this sense, researches on emission control systems will maintain their continuity for a long time. Future standard values to be determined can only be achieved with post-engine emission control systems. The use of post-engine emission control systems is essential to ensure the desired emission values.
\nFuture studies to be performed on NOx emission control methods will focus on optimizing NOx control systems, lowering cost, creating simpler structures, increasing engine efficiency, and increasing NOx conversion efficiency at low exhaust temperatures. The findings and innovations to be achieved as a result of these studies will enable the development of more environmentally friendly diesel vehicles.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Women are diagnosed with PTSD approximately twice as often as men. In this review, we outline the evidence of gender differences related to PTSD, and the factors of resilience and susceptibility differ between men and women.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Jingchu Hu, Biao Feng, Yonghui Zhu, Wenqing Wang, Jiawei Xie\nand Xifu Zheng",authors:[{id:"190985",title:"Dr.",name:"Xifu",middleName:null,surname:"Zheng",slug:"xifu-zheng",fullName:"Xifu Zheng"},{id:"194981",title:"BSc.",name:"Yonghui",middleName:null,surname:"Zhu",slug:"yonghui-zhu",fullName:"Yonghui Zhu"},{id:"194982",title:"MSc.",name:"Wenqing",middleName:null,surname:"Wang",slug:"wenqing-wang",fullName:"Wenqing Wang"},{id:"194985",title:"Dr.",name:"Jingchu",middleName:null,surname:"Hu",slug:"jingchu-hu",fullName:"Jingchu Hu"},{id:"194986",title:"MSc.",name:"Biao",middleName:null,surname:"Feng",slug:"biao-feng",fullName:"Biao Feng"},{id:"194987",title:"Ph.D. Student",name:"Jiawei",middleName:null,surname:"Xie",slug:"jiawei-xie",fullName:"Jiawei Xie"}]},{id:"52472",doi:"10.5772/65410",title:"Gender and Health",slug:"gender-and-health",totalDownloads:3432,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Research has found differences between women and men in some health indicators. 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Gender is one such variable that must be examined with regard to optimizing leadership effectiveness. The topic of gender and leadership deserves serious and thoughtful consideration and discussion because of professional, political, cultural, and personal realities of the twenty‐first century. Women and men have been, are, and should be leaders. Gender must be considered to determine how each leader can reach maximum potential and effectiveness. The FourCe‐PITO conceptual framework of leadership is designed to help guide leadership development and education. The present chapter uses this conceptual framework of leadership to discuss how consideration of gender may affect and optimize leadership development and effectiveness. 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I am giving examples from my developmental psychology research where the split-sample analysis by gender showed amazing and often unexpected effects.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Chris Lange-Küttner",authors:[{id:"190245",title:"Prof.",name:"Chris",middleName:null,surname:"Lange-Küttner",slug:"chris-lange-kuttner",fullName:"Chris Lange-Küttner"}]},{id:"53721",doi:"10.5772/66093",title:"Professional Women's Experience of Autonomy and Independence in Sindh-Pakistan",slug:"professional-women-s-experience-of-autonomy-and-independence-in-sindh-pakistan",totalDownloads:1644,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"This chapter summarises the part of findings of my doctoral studies at the University of Sussex, Brighton, UK. In this case study, there are elements of both qualitative and quantitative approaches; the former is the principal approach to this research while the latter works as complementary. Participants of the research were divided into two categories: academic and non‐academic. Forty semi‐structured interviews (20 from each category) and 100 survey questionnaire (50 from each category) were collected. This research argues that existing concepts of ‘autonomy’ and ‘independence’ may not be useful indices/indicators for measuring the social status or position of women in Sindhi society, due to variations in understanding or the meanings attributed to these concepts across the globe. Findings argue that these professional women perceived concepts of ‘autonomy’, ‘independence’ and ‘individuality’ categorically different than those of Westernised understandings. This research asserts that Sindhi society, similarly to that of Tamil society, emphasises social groups rather than individuals. Hence, ‘collective identities’ are the essence of Sindhi society; however, individuals find their autonomy, independence and individuality in the context of ‘others’, which means to be more responsible for group's interests.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Mukesh Kumar Khatwani",authors:[{id:"196384",title:"Dr.",name:"Mukesh",middleName:"Kumar",surname:"Khatwani",slug:"mukesh-khatwani",fullName:"Mukesh Khatwani"}]}],mostDownloadedChaptersLast30Days:[{id:"52503",title:"Gender and Leadership",slug:"gender-and-leadership",totalDownloads:4125,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"The topic of leadership has been addressed and applied for millennia. Yet, it is only within the past 80 years that leadership has been a topic of serious discussion. It is important to understand variables relevant to effective leadership. 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In this review, we outline the evidence of gender differences related to PTSD, and the factors of resilience and susceptibility differ between men and women.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Jingchu Hu, Biao Feng, Yonghui Zhu, Wenqing Wang, Jiawei Xie\nand Xifu Zheng",authors:[{id:"190985",title:"Dr.",name:"Xifu",middleName:null,surname:"Zheng",slug:"xifu-zheng",fullName:"Xifu Zheng"},{id:"194981",title:"BSc.",name:"Yonghui",middleName:null,surname:"Zhu",slug:"yonghui-zhu",fullName:"Yonghui Zhu"},{id:"194982",title:"MSc.",name:"Wenqing",middleName:null,surname:"Wang",slug:"wenqing-wang",fullName:"Wenqing Wang"},{id:"194985",title:"Dr.",name:"Jingchu",middleName:null,surname:"Hu",slug:"jingchu-hu",fullName:"Jingchu Hu"},{id:"194986",title:"MSc.",name:"Biao",middleName:null,surname:"Feng",slug:"biao-feng",fullName:"Biao Feng"},{id:"194987",title:"Ph.D. Student",name:"Jiawei",middleName:null,surname:"Xie",slug:"jiawei-xie",fullName:"Jiawei Xie"}]},{id:"52472",title:"Gender and Health",slug:"gender-and-health",totalDownloads:3430,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Research has found differences between women and men in some health indicators. Women’s life expectancy is higher than men’s, but research on differences in morbidity has proved less consistent than on the differences in mortality. These differences vary in terms of the type of health indicator used, the life cycle period analyzed, and even the country where research is conducted. Generally, men have more life-threatening chronic diseases at younger ages, including coronary heart disease, as well as more externalizing mental health problems and substance use disorders. Women present higher rates of chronic debilitating conditions such as arthritis, frequent or severe headaches, gallbladder conditions, and also more internalizing mental problems such as affective and anxiety disorders. Results of research on the differences between women and men in self-rated health have also highlighted the complexity of gender differences in health. Although several studies have shown that women have poorer self-rated health than men, this is not the case in all countries. Also, differences in self-rated health vary depending on other psychosocial and demographic variables. The present study reviews the main differences in women’s and men’s health as well as the most relevant factors that may account for them.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"María Pilar Matud",authors:[{id:"189729",title:"Prof.",name:"M. Pilar",middleName:null,surname:"Matud",slug:"m.-pilar-matud",fullName:"M. Pilar Matud"}]},{id:"53212",title:"Broken Dreams—Balancing Self and Family Well-Being: The Experiences of Women Immigrants to Hamilton, ON",slug:"broken-dreams-balancing-self-and-family-well-being-the-experiences-of-women-immigrants-to-hamilton-o",totalDownloads:1512,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter presents the preliminary analysis of a study conducted in Hamilton, ON. It explores the intersection of women’s immigration, integration and mental health. Their perceptions of what is needed from them in relation to the various challenges/changes that moving to a new country entails is a particular focus of this research. To begin with, the term “women immigrant” (WI) is used, rather than immigrant women as commonly used—as the participants were women long before they became immigrants. Indeed immigration is one of their many experiences and it is a significant marker in their lives, but it does not define their identity.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Mirna Carranza",authors:[{id:"189735",title:"Dr.",name:"Mirna",middleName:null,surname:"Carranza",slug:"mirna-carranza",fullName:"Mirna Carranza"}]},{id:"52314",title:"Gender Difference in the Perception of Guilt in Consumer Boycott in Brazil",slug:"gender-difference-in-the-perception-of-guilt-in-consumer-boycott-in-brazil",totalDownloads:1804,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The aim of this chapter is to analyze consumer boycott from the perception of men's and women's guilt on a specific case involving Nike company through partners in its supply chain in China. The study was conducted with 281 consumers in the city of Rio de Janeiro (Brazil) in 2012. In the process of validating a scale of consumer boycott in Brazil, the 13 items of the original scale were kept, but were grouped in different factors. The emerged factors were perception of guilt, influence from others, boycott efficiency, and purchase frequency. Testing relationship among demographic variables and these factors, only gender was significant on perception of guilt. In this sense, we seek in psychology, psychoanalysis (also briefly in anthropology and history), features that could explain the reasons why women feel guiltier than men, and thus are more likely to boycott.",book:{id:"5472",slug:"gender-differences-in-different-contexts",title:"Gender Differences in Different Contexts",fullTitle:"Gender Differences in Different Contexts"},signatures:"Breno de P.A. Cruz, Ricardo José Marques Pires-Jr. and Steven D. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). 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He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,annualVolume:11419,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,annualVolume:11421,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. 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He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. 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The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. 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He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"117248",title:"Dr.",name:"Andrew",middleName:null,surname:"Macnab",slug:"andrew-macnab",fullName:"Andrew Macnab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. 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