\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 179 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 252 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\n'}],latestNews:[{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"}]},book:{item:{type:"book",id:"7776",leadTitle:null,fullTitle:"Research Advances in Chaos Theory",title:"Research Advances in Chaos Theory",subtitle:null,reviewType:"peer-reviewed",abstract:"The subject of chaos has invaded practically every area of the natural sciences. Weather patterns are referred to as chaotic. There are chemical reactions and chaotic evolution of insect populations. Atomic and molecular physics have also seen the emergence of the study of chaos in these microscopic domains. This book examines the issue of chaos in nonlinear and dynamical systems, quantum mechanics, biology, and economics.",isbn:"978-1-78985-544-9",printIsbn:"978-1-78985-543-2",pdfIsbn:"978-1-83880-408-4",doi:"10.5772/intechopen.77590",price:119,priceEur:129,priceUsd:155,slug:"research-advances-in-chaos-theory",numberOfPages:136,isOpenForSubmission:!1,isInWos:null,hash:"e9646ec4b2bff873ce958ed4d5ad7248",bookSignature:"Paul Bracken",publishedDate:"March 11th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7776.jpg",numberOfDownloads:1955,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,hasAltmetrics:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 5th 2019",dateEndSecondStepPublish:"March 25th 2019",dateEndThirdStepPublish:"May 24th 2019",dateEndFourthStepPublish:"August 12th 2019",dateEndFifthStepPublish:"October 11th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,editors:[{id:"92883",title:"Prof.",name:"Paul",middleName:null,surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken",profilePictureURL:"https://mts.intechopen.com/storage/users/92883/images/system/92883.jpg",biography:"Paul Bracken, PhD, is a professor in the Department of Mathematics at the University of Texas, Edinburg. He received a BSc from the University of Toronto and a PhD from the University of Waterloo in Canada. His research interests include applications of differential geometry and partial differential equations to problems in mathematical physics, such as gravity, as well as problems in quantum mechanics and quantum field theory. He has published more than 160 papers in journals and books and presented talks at numerous meetings and conferences. This is the sixth volume he has contributed with IntechOpen.",institutionString:"The University of Texas Rio Grande Valley",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"9",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"The University of Texas Rio Grande Valley",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"966",title:"Dynamical Systems Theory",slug:"dynamical-systems-theory"}],chapters:[{id:"68637",title:"Introductory Chapter: Dynamical Symmetries and Quantum Chaos",doi:"10.5772/intechopen.88551",slug:"introductory-chapter-dynamical-symmetries-and-quantum-chaos",totalDownloads:261,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Paul Bracken",downloadPdfUrl:"/chapter/pdf-download/68637",previewPdfUrl:"/chapter/pdf-preview/68637",authors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],corrections:null},{id:"67820",title:"Loop-like Solitons",doi:"10.5772/intechopen.86583",slug:"loop-like-solitons",totalDownloads:251,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Vyacheslav O. Vakhnenko, E. John Parkes and Dmitri B. Vengrovich",downloadPdfUrl:"/chapter/pdf-download/67820",previewPdfUrl:"/chapter/pdf-preview/67820",authors:[{id:"296741",title:"D.Sc.",name:"Vyacheslav",surname:"Vakhnenko",slug:"vyacheslav-vakhnenko",fullName:"Vyacheslav Vakhnenko"},{id:"297430",title:"Dr.",name:"John",surname:"Parkes",slug:"john-parkes",fullName:"John Parkes"},{id:"297433",title:"Dr.",name:"Dmitri",surname:"Vengrovich",slug:"dmitri-vengrovich",fullName:"Dmitri Vengrovich"}],corrections:null},{id:"68059",title:"Complex Dynamical Behavior of a Bounded Rational Duopoly Game with Consumer Surplus",doi:"10.5772/intechopen.87200",slug:"complex-dynamical-behavior-of-a-bounded-rational-duopoly-game-with-consumer-surplus",totalDownloads:404,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Wei Zhou and Tong Chu",downloadPdfUrl:"/chapter/pdf-download/68059",previewPdfUrl:"/chapter/pdf-preview/68059",authors:[{id:"299554",title:"Dr.",name:"Wei",surname:"Zhou",slug:"wei-zhou",fullName:"Wei Zhou"},{id:"303076",title:"Dr.",name:"Tong",surname:"Chu",slug:"tong-chu",fullName:"Tong Chu"}],corrections:null},{id:"68754",title:"Nonlinear Dynamical Regimes and Control of Turbulence through the Complex Ginzburg-Landau Equation",doi:"10.5772/intechopen.88053",slug:"nonlinear-dynamical-regimes-and-control-of-turbulence-through-the-complex-ginzburg-landau-equation",totalDownloads:224,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Joël Bruno Gonpe Tafo, Laurent Nana, Conrad Bertrand Tabi and Timoléon Crépin Kofané",downloadPdfUrl:"/chapter/pdf-download/68754",previewPdfUrl:"/chapter/pdf-preview/68754",authors:[{id:"159260",title:"Dr.",name:"Kofane Timoléon",surname:"Crépin",slug:"kofane-timoleon-crepin",fullName:"Kofane Timoléon Crépin"},{id:"293382",title:"Prof.",name:"Tabi",surname:"Conrad Bertrand",slug:"tabi-conrad-bertrand",fullName:"Tabi Conrad Bertrand"},{id:"296959",title:"Dr.",name:"Joel Bruno",surname:"Gonpe Tafo",slug:"joel-bruno-gonpe-tafo",fullName:"Joel Bruno Gonpe Tafo"},{id:"296961",title:"Prof.",name:"Laurent",surname:"Nana",slug:"laurent-nana",fullName:"Laurent Nana"}],corrections:null},{id:"68587",title:"Ubiquitous Filtering for Nonlinear Problems",doi:"10.5772/intechopen.88409",slug:"ubiquitous-filtering-for-nonlinear-problems",totalDownloads:283,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Valeri Kontorovich and Fernando Ramos-Alarcon",downloadPdfUrl:"/chapter/pdf-download/68587",previewPdfUrl:"/chapter/pdf-preview/68587",authors:[{id:"42898",title:"Prof.",name:"Valeri",surname:"Kontorovich",slug:"valeri-kontorovich",fullName:"Valeri Kontorovich"}],corrections:null},{id:"68375",title:"Chaos in Human Brain Phase Transition",doi:"10.5772/intechopen.86667",slug:"chaos-in-human-brain-phase-transition",totalDownloads:325,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Mibaile Justin, Malwe Boudoue Hubert, Gambo Betchewe, Serge Yamigno Doka and Kofane Timoleon Crepin",downloadPdfUrl:"/chapter/pdf-download/68375",previewPdfUrl:"/chapter/pdf-preview/68375",authors:[{id:"295714",title:"Ph.D.",name:"Justin",surname:"Mibaile",slug:"justin-mibaile",fullName:"Justin Mibaile"},{id:"303306",title:"Dr.",name:"Hubert",surname:"Malwe",slug:"hubert-malwe",fullName:"Hubert Malwe"}],corrections:null},{id:"70670",title:"Global Indeterminacy and Invariant Manifolds Near Homoclinic Orbit to a Real Saddle",doi:"10.5772/intechopen.90308",slug:"global-indeterminacy-and-invariant-manifolds-near-homoclinic-orbit-to-a-real-saddle",totalDownloads:207,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Beatrice Venturi",downloadPdfUrl:"/chapter/pdf-download/70670",previewPdfUrl:"/chapter/pdf-preview/70670",authors:[{id:"298359",title:"Associate Prof.",name:"Beatrice",surname:"Venturi",slug:"beatrice-venturi",fullName:"Beatrice Venturi"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},relatedBooks:[{type:"book",id:"3513",title:"Advances in Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"bbea1c081216f267a4480707f4ead9cf",slug:"advances-in-quantum-mechanics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/3513.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5488",title:"Manifolds",subtitle:"Current Research Areas",isOpenForSubmission:!1,hash:"e1193790ca2c8027d4ffc6911dd24365",slug:"manifolds-current-research-areas",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/5488.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5213",title:"Research Advances in Quantum Dynamics",subtitle:null,isOpenForSubmission:!1,hash:"15678b0555c714101f8d707a46b4ac60",slug:"research-advances-in-quantum-dynamics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/5213.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10076",title:"Quantum Mechanics",subtitle:null,isOpenForSubmission:!1,hash:"78f2b316d6bb97464dbbf9b683164aff",slug:"quantum-mechanics",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/10076.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7342",title:"Manifolds II",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"97f5bd89a6e5006ea10d90df5a6df5a5",slug:"manifolds-ii-theory-and-applications",bookSignature:"Paul Bracken",coverURL:"https://cdn.intechopen.com/books/images_new/7342.jpg",editedByType:"Edited by",editors:[{id:"92883",title:"Prof.",name:"Paul",surname:"Bracken",slug:"paul-bracken",fullName:"Paul Bracken"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2508",title:"Nonlinearity, Bifurcation and Chaos",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"cce4e2af0e23321e7072373518985b63",slug:"nonlinearity-bifurcation-and-chaos-theory-and-applications",bookSignature:"Jan Awrejcewicz and Peter Hagedorn",coverURL:"https://cdn.intechopen.com/books/images_new/2508.jpg",editedByType:"Edited by",editors:[{id:"68338",title:"Prof.",name:"Jan",surname:"Awrejcewicz",slug:"jan-awrejcewicz",fullName:"Jan Awrejcewicz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5513",title:"Dynamical Systems",subtitle:"Analytical and Computational Techniques",isOpenForSubmission:!1,hash:"9ba4129f30ef1b92fd4b7ae193781183",slug:"dynamical-systems-analytical-and-computational-techniques",bookSignature:"Mahmut Reyhanoglu",coverURL:"https://cdn.intechopen.com/books/images_new/5513.jpg",editedByType:"Edited by",editors:[{id:"15068",title:"Dr.",name:"Mahmut",surname:"Reyhanoglu",slug:"mahmut-reyhanoglu",fullName:"Mahmut Reyhanoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5804",title:"Fractal Analysis",subtitle:"Applications in Physics, Engineering and Technology",isOpenForSubmission:!1,hash:"a3d42b4b44ba9d7d72f0e91442da7b4b",slug:"fractal-analysis-applications-in-physics-engineering-and-technology",bookSignature:"Fernando Brambila",coverURL:"https://cdn.intechopen.com/books/images_new/5804.jpg",editedByType:"Edited by",editors:[{id:"60921",title:"Dr.",name:"Fernando",surname:"Brambila",slug:"fernando-brambila",fullName:"Fernando Brambila"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6216",title:"Complexity in Biological and Physical Systems",subtitle:"Bifurcations, Solitons and Fractals",isOpenForSubmission:!1,hash:"c511a26efc1b9c0638c8f9244240cb93",slug:"complexity-in-biological-and-physical-systems-bifurcations-solitons-and-fractals",bookSignature:"Ricardo López-Ruiz",coverURL:"https://cdn.intechopen.com/books/images_new/6216.jpg",editedByType:"Edited by",editors:[{id:"9849",title:"Prof.",name:"Ricardo",surname:"Lopez-Ruiz",slug:"ricardo-lopez-ruiz",fullName:"Ricardo Lopez-Ruiz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6651",title:"Nonlinear Systems",subtitle:"Modeling, Estimation, and Stability",isOpenForSubmission:!1,hash:"085cfe19a4bd48a9e8034b2e5cc17172",slug:"nonlinear-systems-modeling-estimation-and-stability",bookSignature:"Mahmut Reyhanoglu",coverURL:"https://cdn.intechopen.com/books/images_new/6651.jpg",editedByType:"Edited by",editors:[{id:"15068",title:"Dr.",name:"Mahmut",surname:"Reyhanoglu",slug:"mahmut-reyhanoglu",fullName:"Mahmut Reyhanoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"66066",slug:"erratum-microbial-responses-to-different-operating-practices-for-biogas-production-systems",title:"Erratum - Microbial Responses to Different Operating Practices for Biogas Production Systems",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/66066.pdf",downloadPdfUrl:"/chapter/pdf-download/66066",previewPdfUrl:"/chapter/pdf-preview/66066",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/66066",risUrl:"/chapter/ris/66066",chapter:{id:"65614",slug:"microbial-responses-to-different-operating-practices-for-biogas-production-systems",signatures:"Maria Westerholm and Anna Schnürer",dateSubmitted:"June 11th 2018",dateReviewed:"November 30th 2018",datePrePublished:"February 12th 2019",datePublished:"September 4th 2019",book:{id:"6839",title:"Anaerobic Digestion",subtitle:null,fullTitle:"Anaerobic Digestion",slug:"anaerobic-digestion",publishedDate:"September 4th 2019",bookSignature:"J. Rajesh Banu",coverURL:"https://cdn.intechopen.com/books/images_new/6839.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"218539",title:"Dr.",name:"Rajesh",middleName:null,surname:"Banu",slug:"rajesh-banu",fullName:"Rajesh Banu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"262546",title:"Prof.",name:"Anna",middleName:null,surname:"Schnürer",fullName:"Anna Schnürer",slug:"anna-schnurer",email:"anna.schnurer@slu.se",position:null,institution:null},{id:"263116",title:"Dr.",name:"Maria",middleName:null,surname:"Westerholm",fullName:"Maria Westerholm",slug:"maria-westerholm",email:"Maria.Westerholm@slu.se",position:null,institution:null}]}},chapter:{id:"65614",slug:"microbial-responses-to-different-operating-practices-for-biogas-production-systems",signatures:"Maria Westerholm and Anna Schnürer",dateSubmitted:"June 11th 2018",dateReviewed:"November 30th 2018",datePrePublished:"February 12th 2019",datePublished:"September 4th 2019",book:{id:"6839",title:"Anaerobic Digestion",subtitle:null,fullTitle:"Anaerobic Digestion",slug:"anaerobic-digestion",publishedDate:"September 4th 2019",bookSignature:"J. Rajesh Banu",coverURL:"https://cdn.intechopen.com/books/images_new/6839.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"218539",title:"Dr.",name:"Rajesh",middleName:null,surname:"Banu",slug:"rajesh-banu",fullName:"Rajesh Banu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"262546",title:"Prof.",name:"Anna",middleName:null,surname:"Schnürer",fullName:"Anna Schnürer",slug:"anna-schnurer",email:"anna.schnurer@slu.se",position:null,institution:null},{id:"263116",title:"Dr.",name:"Maria",middleName:null,surname:"Westerholm",fullName:"Maria Westerholm",slug:"maria-westerholm",email:"Maria.Westerholm@slu.se",position:null,institution:null}]},book:{id:"6839",title:"Anaerobic Digestion",subtitle:null,fullTitle:"Anaerobic Digestion",slug:"anaerobic-digestion",publishedDate:"September 4th 2019",bookSignature:"J. Rajesh Banu",coverURL:"https://cdn.intechopen.com/books/images_new/6839.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"218539",title:"Dr.",name:"Rajesh",middleName:null,surname:"Banu",slug:"rajesh-banu",fullName:"Rajesh Banu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"9858",leadTitle:null,title:"Climate and Ecology of Holocene",subtitle:null,reviewType:"peer-reviewed",abstract:"This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,hash:"e4f2d361bf0521f27d50aab719db5045",bookSignature:"",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/9858.jpg",keywords:null,numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 6th 2019",dateEndSecondStepPublish:"June 27th 2019",dateEndThirdStepPublish:"August 26th 2019",dateEndFourthStepPublish:"November 14th 2019",dateEndFifthStepPublish:"January 13th 2020",remainingDaysToSecondStep:"2 years",secondStepPassed:!0,currentStepOfPublishingProcess:1,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"10",title:"Earth and Planetary Sciences",slug:"earth-and-planetary-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"5962",title:"Estuary",subtitle:null,isOpenForSubmission:!1,hash:"43058846a64b270e9167d478e966161a",slug:"estuary",bookSignature:"William Froneman",coverURL:"https://cdn.intechopen.com/books/images_new/5962.jpg",editedByType:"Edited by",editors:[{id:"109336",title:"Prof.",name:"William",surname:"Froneman",slug:"william-froneman",fullName:"William Froneman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophanides",surname:"Theophile",slug:"theophanides-theophile",fullName:"Theophanides Theophile"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"64533",title:"Resveratrol in Management of Diabetes and Obesity: Clinical Applications, Bioavailability, and Nanotherapy",doi:"10.5772/intechopen.79498",slug:"resveratrol-in-management-of-diabetes-and-obesity-clinical-applications-bioavailability-and-nanother",body:'\nDiabetes mellitus (DM) has been an ever-increasing global epidemic and one of the most challenging health problems of twenty-first century. In 2010, more than 285 million people about the world were afflicted with diabetes, and it was then calculated that the number of people with diabetes will increase to 439 million by 2030. Interestingly, the reports of 2015 show that globally 415 million (215.2 million men and 199.5 million women) had DM with a prevalence of 8.8%, and projections indicate that approximately 600 million people would be suffering from diabetic in 2030. In other words, one in eleven people has DM. The economic impact of diabetes is extensive. A significant component of health care expenditures is attributed to diabetes, and its complications and global spending for treating it in 2015 alone were US$ 673 billion (12% of health expenditure) [1].
\nTwo primary groups of DM are distinguished: (1) autoimmune T1DM or insulin-dependent DM or juvenile DM and (2) T2DM or noninsulin-dependent DM or maturity onset DM. Close to 90% of people with DM around the world have type 2 DM (T2DM) [2].
\nThe treatment of T1DM requires insulin replacement via injections as the pancreatic β-cells are destroyed and do not secrete adequate insulin. On the other hand, T2DM is characterized by insulin resistance and a decreased capacity of insulin secretion by β-cells. Natural/herbal medicines that have claimed to be effectual in the treatment of DM are thus more efficient in the treatment of T2DM [3]. They act either as insulin sensitizers or as substances that reduce the plasma glucose levels.
\nFurther recent inventions on natural products have established a new understanding into the use of antioxidants to combat diabetic complications [4]. Oxidative stress leads to the dysfunction of β-cells and thus plays a crucial role in the pathogenesis of diabetes and its associated complications. In fact, increasing morbidity and mortality rates of T2DM patients are mainly due to the high occurrence and severity of diabetic complications.
\nThus, β-cells apoptosis can be protected, and their functions can be preserved by the use of antioxidants [5]. Thus, a potent antioxidant compound is expected to show greater effects on diabetes and its associated complications. Therefore, antioxidant therapy is, a different, innovative but, a fundamental approach for treating diabetic complications [6, 7].
\nThe antioxidant activity and its related health benefits of dietary plant polyphenols are well documented. In recent years, there is growing evidence on the effectiveness of plant polyphenols against the treatment of type 2 diabetes mellitus and its ramifications. Polyphenols may be classified into different groups as a function of the number of phenol rings that they contain and on the basis of structural elements that bind these rings to one another. The main classes include flavonoids, phenolic acids, β-orcinols, stilbenes, and lignans. Figure 1 illustrates the different groups of polyphenols and their chemical structures reported as antioxidant and antidiabetic activities.
\nChemical structure of major classes of polyphenols reported for antioxidant and antidiabetic effects.
The hypoglycemic effects of polyphenols are mainly ascribed for reducing the intestinal absorption of dietary carbohydrate, for the modulation of carbohydrate and lipid metabolism enzymes, and they stimulate insulin secretion and insulin action and improve β-cell functions by reducing oxidative stress, stress-sensitive signaling pathways, and inflammatory processes [8].
\nWe have already reviewed the antidiabetic effect of least-studied β-orcinol compounds of lichen origin and found in accordance of its antioxidant and antidiabetic effect [9]. The current chapter focuses on the reported antidiabetic effect of stilbenoid type polyphenols. Stilbenoids are phylotaxins and are mainly found in Vitis vinifera L., the wine producing grape fruits, together with other plant families, such as Dipterocarpaceae, Gnetaceae, and Fabaceae.
\nThe backbone structure of stilbene which is 1,2-diphenylethylene is common, but the type and position of substituents on the rings differ. The hydroxylated derivatives of stilbenes provide the class with a wide variety of polymerization and oligomeric construction. However, the most widely studied hydroxylated stilbenoid is resveratrol (3,5,4′-trihydroxystilbene), which is considered as one of most potent natural biological active compound. The other structural analogs with potentially beneficial medicinal properties include pterostilbene (methylated derivatives), viniferin (glycone derivatives), and hopeaphenol (oligomeric forms—tetramer). Some of the common stilbenoid structures are illustrated in Figure 2.
\nMost common stilbene derivatives reported for antidiabetic activities.
Biological activities of resveratrol have been well examined by a great variety of test systems. Its beneficial properties on humans include neuroprotective, antiviral, antiatherogenic, and estrogen-like growth-promoting effect. Further, its effects on promotion of vasodilatation and prevention of platelet aggregation and its positive effect on the circulatory system especially by increasing production of high-density lipoprotein cholesterol and preventing the development of arteriosclerosis are reported. Furthermore, it was shown that resveratrol is a chemopreventive agent [10]. Due to the wide variety of biological activities shown by this marvel compound, resveratrol-based medicinal chemistry has become rapidly evolving and increasingly active topics in the past decade, covering almost the whole range of therapeutic fields. There are several reports composing the antioxidant, antiinflammatory, and antidiabetic effect of resveratrol. Due to its antiinflammatory and antioxidant effects, resveratrol can mitigate the development of diabetic complications associated with inflammation and oxidative stress. Beneficial effects of resveratrol on the management of blood glucose in diabetes are summarized in Figure 3. The aim of this chapter is to highlight the importance of resveratrol along with other stilbenes as an antidiabetic compound with antioxidant properties.
\nBeneficial effects of resveratrol on the management of blood glucose in diabetes.
The appreciable magnitude of scientific evidence is available, which ascribes antidiabetic properties of resveratrol and fights against obesity. There are over 800 publications ascribing the hypoglycemic action of resveratrol, through both in-vivo and in-vitro studies. Multiple modes of action, and diversity of molecular targets, keep resveratrol well ahead of its other natural analogs. Modes of action include inhibition of carbohydrate hydrolyzing enzymes (α-amylase and α-glucosidase), through their role as an effective antioxidants and through their effect on amelioration of insulin sensitivity. The resveratrol improves defective insulin signaling, prevents pancreatic β-cell apotopsis and dysfunction, inhibits abnormal glucose uptake and storage, mitigates hyperlipidemia and dyslipidemia, and thus shows high pharmokinetic potential as antidiabetic agent [11]. The complex physiological action of resveratrol as an antidiabetic agent could be attributed to its capacity to modulate different pathways and to its diversity of molecular targets including phospodiesterases, adenylyl cyclase, kinases, sirtuins, transcription factors, cytokines, and others, some of which are described below.
\nPancreatic β-cells are key players in the development of T2DM, as they are required to secrete increasing amounts of insulin so as to compensate for increasing insulin resistance. Consequently, the β-cells come under increasing metabolic stress and finally their function deteriorates. Thus, it is important to find a mean to preserve the health of β-cells.
\nCyclic nucleotide phosphodiesterases (PDEs) belong to a class of enzymes that hydrolyze the phosphodiester bonds of cAMP and cGMP to their biologically inactive 5′ derivatives. Cyclic AMP is known as a key mediator of metabolic regulation. Resveratrol acts as PDE inhibitor, leading to increased cAMP levels, which amplifies glucose-induced insulin secretion [12].
\nResveratrol triggers cascade of biological pathways that are induced during calorie restriction. Primarily increased cAMP levels activate PKA (protein kinase A), which directly phosphorylates and activates histone deacetylase Sirtuin1 (SIRT1), which increases insulin sensitivity and protects against metabolic damage resulting from a high-fat diet. In detail, SIRT1 catalyzes NAD+-dependent protein deacetylation, yielding nicotinamide and O-acetyl-ADP-ribose. SIRT1 facilitates the conversion of changes in the nutritional status, which it senses via NAD+ levels, mediates the metabolic stress situations, such as high-fat-diet-induced obesity, and plays a context-dependent role in health span regulation. In addition to the c-AMP mediated pathway, resveratrol also increases SIRT1 activity through an allosteric interaction, resulting in the increase of SIRT1 affinity for both NAD+ and the acetylated substrate. SIRT1 promotes many beneficial metabolic changes, such as an increase in fatty acid oxidation, gluconeogenesis, and mitochondrial respiration and a decrease in triglyceride synthesis, glycolysis, ROS production, and inflammation. In light of the rising number of patients suffering from metabolic diseases, compounds that activate SIRT1 directly or indirectly offer protection against the onset of metabolic damage and encourage healthy aging [13].
\nThe regulation of glucose uptake and its subsequent utilization is critical for the maintenance of glucose homeostasis. Homeostasis of blood glucose by insulin involves stimulation of glucose uptake by translocation of glucose transporter Glut-4 from intracellular pool to the caveolar membrane system. Resveratrol increases the expression of this glucose transporter Glu-4 and excites the glucose uptake.
\nSkeletal muscle is the largest organ in the body and contributes to immeasurable features of organismal biology, and its dysfunction stimulates numerous diseases, including diabetes. Skeletal muscle is the main site of glucose disposal after glucose ingestion. Insulin resistance in skeletal muscle is thus the main driver of postprandial hyperglycemia. The transcriptional coactivator PGC-1α has emerged as a key driver of metabolic programming in skeletal muscle, both in muscle health and disease. PGC-1α has different roles in different tissues, but in nearly every context, PGC-1α stimulates the transcriptional program of mitochondrial biogenesis. PGC-1α dysfunction, and thus mitochondrial insufficiency, contributes to insulin resistance in skeletal muscle. Resveratrol also has proven to enhance the PGC-1α–skeletal muscle protein levels.
\nFurther resveratrol also activates Akt expression, a modulator of insulin-signaling pathway. Akt is the major effector of the IR-IRS-1-PI3K pathway and is activated by phosphorylation. Resveratrol treatment increases the phosphorylation level of Akt, particularly of its Thr308 and Ser473 residues which is essential for its basal and full activation.
\nSeveral studies have found that resveratrol has positive effects on inhibiting the insulin secretion from pancreatic β-cells and prevents it from chronic overstimulation, decreases the plasm insulin concentration, and increases the insulin sensitivity. Possible explanations include resveratrol-mediated suppression of cytokine action through decreased DNA binding of nuclear transcription factor κB, production of nitric oxide, and expression of inducible nitric oxide synthesis [14].
\nThe advancement in the knowledge of potent antioxidants has uncovered the way for greater insight in the treatment of diabetic complications. The antioxidant activity of resveratrol is well proven, and there is a good accordance between antioxidant and antidiabetic activity of resveratrol. Resveratrol maintains the concentration of intracellular antioxidants in biological systems by dual methods, that is, by acting as scavenger of free radicals and by increasing the activity of antioxidant enzymes such as catalase, glutathione peroxidase, glutathione S-transferase, and glutathione reductase [14]. In a study on isolated liver mitochondria, addition of resveratrol to the incubation medium significantly increased the activity of manganese-containing superoxide dismutase and diminishes ROS generation. Resveratrol acts as a free radical scavenger of ROS and reactive nitrogen species such as superoxide anion (O2•−), hydroxyl radical (OH•), and hydrogen peroxide, thus, prevent DNA lesions and lipid peroxidation in cell membranes. It has been shown that resveratrol significantly reduced the oxidation of thiol groups in proteins of human platelets [15].
\nα-Amylase and α-glucosidase are key enzymes involved in carbohydrate digestion. α-Amylase hydrolyzes starch and glycogen into maltose and ultimately increases the blood sugar. α-Glucosidase hydrolyzes oligosaccharides and disaccharides into glucose, which is absorbed through the gut wall to become blood glucose. Thus, inhibition of the activity of these enzymes is viewed as one of the most effective therapeutic approaches in the reduction of glucose levels in plasma, as a consequence, the suppression of postprandial hyperglycemia.
\nVarious plant extracts containing resveratrol have been evaluated for α-amylase inhibitory activity and have shown beneficial effects in bringing down the pace of digestion and assimilation of sugars and thereby leading to the effective management of type 2 diabetes by decreasing the postprandial hyperglycemia, some of which are highlighted below.
\nAntioxidant and α-glucosidase inhibitory potential of reservatrol isolated from Rumex bucephalophorus have been reported, which revealed that reservatrol was at least five times more potent α-glucosidase inhibitory activity as compared to standard drug acarbose [16]. A study on peanut extracts correlated the reservatrol content with the α-amylase and α-glucosidase inhibitory activity. The EtOAc extracts of peanuts with higher resveratrol content (3 μg/ml) showed higher α-amylase and α-glucosidase inhibitory activity (4.32 and 5.93%, respectively) as compared to MeOH extract (3.9 and 4.9%) with resveratrol content of (0.5 μg/ml). The standard resveratrol sample showed α-amylase and α-glucosidase inhibitory activity (5.18 and 5.94%) [17].
\nIn another study, resveratrol had shown potent α-glucosidase inhibitory activity against both yeast and mammal α-glucosidase with (IC50, 0.091 mg/ml) and (IC50, 0.12 mg/ml), respectively. The standard drug acarbose showed IC50 = 0.247 mg/ml (yeast α-glucosidase) and IC50 = 0.013 μg/ml (mammal α-glucosidase) [15]. Piceatannol, with an additional OH group as compared to resveratrol, showed higher α-glucosidase inhibitory activity as compared to resveratrol [18].
\nIn a study, wistar rats when administered with 30 mg/kg BW resveratrol 60 min prior to sucrose- or starch-loading had a delayed absorption of carbohydrates, resulting in significant lowering of postprandial blood glucose concentrations [18].
\nThe structure activity relationship of polyphenols isolated from other plant sources has been extensively reviewed as inhibitors of α-amylase and α-glucosidase. Detailed SAR has revealed that both α-amylase and α-glucosidase share the same properties in terms of structural requirements for inhibition [19]. Studies reveal that inhibitory activity is influenced by a number of hydroxyl groups and their positions, methylation, methoxylation, glycosylation, etc. Broadly, it is considered that hydroxylation of phenols increases the α-amylase inhibitory activity and methoxylation, which blocks the free hydroxyl groups and reduces the inhibitory activity [19]. Apparently, the activity is increased by more phenolic substitutions. Piceatannol with four OH groups showed higher activity than resveratrol with three free hydroxyl groups as for the study of Zhang et al. [18]. This is further evident by the study of Lam et al. [26], where several stilbenoids isolated from seeds of Syagrus romanzoffiana were evaluated for inhibitory activity against α-glucosidase Bacillus stearothermophilus. Pentahydroxystilbene (5 OH groups) showed higher inhibitory activity (IC50 19.23 μM) as compared to piceatannol with 4 OH groups (IC50 23.24 μM).
\nMolecular docking studies have revealed that, overall, the inhibitory activity of phenols depends on two parameters: (i) hydrogen bonding capacity of the OH groups of the phenols with the side chains of amino acids such as Asp197 and Glu233, and (ii) planarity of aromatic rings to form an efficient conjugated π-π system with the indole Trp59 of the active site [20].
\n(+) Hopeaphenol and (−) hopeaphenol oligomer (tetramer) of resveratrol isolated from Ampelocissus indica (L.) and Vateria indica Linn., respectively, displayed IC50 values of 21.21 ± 0.987 and 9.47 ± 0.967 mM in an α-glucosidase inhibitory assay [21], which were higher than the standard acarbose (IC50 81.3 ± 1.10). The compounds showed a concentration-dependent inhibition of both α-glucosidase and α-amylase enzymes. Further, the study also indicated the positive effect of hopeaphenols as antiglycating agents, with IC50 values of 81.9 ± 1.176 and 50.96 ± 0.897, respectively, for (+) and (−) isomers which again were less than the ascorbic acid standard (IC50 158.23 ± 0.718). The results indicated that the hopeaphenols can be a promising natural compound in diabetic management [21]. The effect of glucose uptake performed by 2-NBDG in L6 rat skeletal muscle cells using flow cytometry (BD FACS Aria II, USA) showed potent glucose uptake by (+) and (−) hopeaphenol of 31 and 26.4%, respectively [21].
\nFew reports exist on the in-vivo studies of stilbenoids other than resveratrol. Among them is the effect of pterostilbene, which improves glycemic control in insulin-resistant obese rats by increasing hepatic glucokinase activity and increasing skeletal muscle glucose uptake [22]. In vitro studies also indicate that pterostilbene protected pancreatic beta cells against oxidative stress and apoptosis [23]. Antihyperglycemic properties of pterostilbene along with other phenolic constituents of Pterocarpus marsupium have been reported [24, 25], whereas pterostilbene has been shown to be beneficial in animal models of diabetes and metabolic disorders. Further, the study by Lam et al. also revealed that pentahydroxystilbene (3,3′,4,4′,5′-pentahydroxy-trans-stilbene) possesses significant effect in reducing the postprandial blood glucose level of sucrose-challenged normal wistar rats [26].
\nAlthough numerous data exist on the beneficial outcomes of resveratrol in diabetic animals and in vitro, there are limited studies that have specifically investigated the antidiabetic effects of resveratrol in humans. Further, because of not only a limited number of clinical surveys, but also limited sample size and conflicting data, the use of resveratrol as an effective antidiabetic agent has been delayed [27]. Few of the reported clinical trial data are discussed below.
\nGlycated hemoglobin (HbA1c) levels reflect glycemic control and can, consequently, be employed as a predictor of the microvascular and macrovascular complications associated with type 2 diabetes. HbA1c levels seem to be determined by postprandial hyperglycemia. Bhatt and colleagues demonstrated that resveratrol (250 mg/day for 3 months) administered along with glibenclamide and/or metformin demonstrated improvement in glycaemic parameters in diabetic patients as compared to metformin or glibenclamide alone [28]. The study reported improvement in HbA1c, systolic blood pressure, and total cholesterol in patients with type 2 DM treated with resveratrol combined with the oral hypoglycemic agents. Recently, Movahed and colleagues also reported [29] that 1 g/day of resveratrol supplementation for 45 days notably reduced fasting blood glucose, HbA1c, insulin, and systolic blood pressure. Brasnyó and colleagues [30] reported an improvement in insulin sensitivity in type 2 diabetic patients after treatment with a much lower dose of resveratrol (5 mg twice daily) for 4 weeks. The study showed that resveratrol did not cause any changes in a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) levels in diabetes patients. However, they did show that resveratrol significantly decreased insulin resistance and blood glucose and delayed glucose peaks after meals. In the study, resveratrol treatment was shown to significantly decrease HbA1c, systolic blood pressure, and total cholesterol. A decrease in oxidative stress assessed by measuring urinary ortho-tyrosine excretion, a bio marker of oxidative stress, was also reported. Nevertheless, the authors found no evidence that resveratrol influenced homeostasis model of assessment of β-cell function (HOMA-β) and therefore suggested that the mechanism of antidiabetic effects might be referable to a reduction in oxidative stress and a more-efficient insulin signaling. Resveratrol activated the Akt insulin signaling pathway by increasing the phosphoAkt:Akt ratio in platelets.
\nMost significant notice from the above two studies is the extra security of resveratrol as compared to available standard antidiabetic medication [31].
\nIn contrast, in a randomized control trial by Thazhath et al., 500 mg of resveratrol was administration twice daily for 5 weeks in diet-controlled type 2 diabetes. The study revealed no significant improvement in glycemic control [32]. They studied two incretin hormones that affect postprandial hyperglycemia: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) from the bowel. In healthy people, both hormones stimulate insulin, but in type 2 patients, only GLP-1 can act to stimulate insulin. GLP-1 can also suppress glucagon secretion and energy intake and slow gastric emptying, thereby targeting postprandial hyperglycemia. In rodent models, resveratrol has been shown to upregulate GLP-1 and lower glycemia, but Thazhath et al. found that in human patients, there was no difference between the GLP-1 secretion, fasting glucose level, postprandial glucose level, HbA1c, gastric emptying, body weight, or energy intake in the resveratrol-treated versus the placebo group. As such, resveratrol’s efficacy in improving glycemic control is indeterminate. Similarly, resveratrol treatment for 6 months did not improve metabolic parameters in type 2 diabetic patients [33].
\nCrandall et al. studied older adults with impaired glucose tolerance (IGT), a major risk factor for diabetes as well as cardiovascular disease. They establish that although fasting plasma glucose was unchanged with low dose of resveratrol treatment, peak postmeal glucose and 3-h glucose declined. Further postmeal insulin decreased and insulin sensitivity imporved. Thus, established resveratrol as a promising therapy for insulin resistance [34].
\nA meta-analysis was carried out by Liu et al. in 2014 [35] and more recently by Zhu et al. in 2017 [36] with the aim of qualitatively comparing the published data on effect of resveratrol on plasma glucose levels, glycated hemoglobin (HbA1c), and insulin sensitivity. A fixed-effect model analysis was carried out to pool the data, nine studies with 283 participants in case by study of Zhu et al. and 388 participants of 11 eligible studies in case of Liu et al. The sample size of studies varied from 8 to 66 participants, with resveratrol dose ranging from 8 mg/d to 3000 mg/d and with duration of intervention differing from 2 weeks to 12 months. Both meta-analysis studies revealed that resveratrol was able to reduce the fasting plasma glucose levels only at high concentrations (1 g/day) as compared with placebo/control in patients with T2DM. Resveratrol was unable to reduce the plasma glucose levels at low concentrations. These studies also revealed that compared to placebo group, the patients who received resveratrol supplement also showed low insulin levels. Further resveratrol was also effective in reducing the systolic and diastolic blood pressures. However, no significant difference was observed in LDL and HDL levels.
\nOn the other hand, effect of pterostilbene on human type 2 diabetes is yet to be researched. Administration of blueberry (Vaccinium myrtillus) and sea buckthorn (Hippophae rhamnoides) extract for children with type 1 diabetes for 2 months elicited a reduction in HBA1c levels and an increase in SOD and glutathione peroxidase levels [37]. Since pterostilbene has been isolated from Vaccinium myrtillus [38], this effect may be ascribable to the presence of pterostilbene alongside other bioactive compounds in the excerpt.
\nSome beneficial effects have also been reported in resveratrol treatment in nondiabetic humans. In obese subjects, Timmers and colleagues [39] reported significant improvement in the metabolic profile and general health after resveratrol supplementation for 30 days, thereby describing resveratrol as a calorie restriction mimetic. Resveratrol showed beneficial effects on glucose homeostasis and insulin sensitivity, reduced intrahepatic lipid (IHL) content and expression of inflammatory genes and improved mitochondrial efficiency. These effects may be linked with the activation of AMPK and increased SIRT1 and PGC-1α protein content in the muscle [39].
\nOne of the major challenges surrounding the clinical utility of resveratrol is achieving its stability and adequate bioavailability at tolerable doses—a common issue in translating promising findings from cell culture and animal models into clinical efficacious drugs. Recent clinical trials proved that resveratrol is well tolerated and pharmacologically safe at doses up to 5 g/day. However, the data on toxicity of resveratrol in long-term experiments are scarce.
\nLow solubility of resveratrol in water (<0.05 mg/ml), caused by its chemical structure, affects its absorption. Its reported oral bioavailability values range from 20 to 29.8%. After intravenous administration, resveratrol exhibited a very short half-life of 14 min due to rapid metabolism. This poor bioavailability can be ascribed to the rapid conjugation of trans-resveratrol to glucuronic acid and sulfates, producing glucuronides and sulfate conjugates that accumulate in plasma and urine.
\nIn detail, resveratrol is absorbed in a relatively high rate through the small intestine either via passive diffusion due to its nonpolar character or through active diffusion across the intestinal epithelium via cell ATP-dependent binding cassette transporters. Inside the enterocytes of the small intestine and hepatocytes of the liver, the glucuronide and sulfate conjugation of trans-resveratrol to the major metabolites are extensive. This conjugation to sulfates and glucuronides increases resveratrol’s aqueous solubility, reduces flux across membranes, preventing nonpolar molecules from interacting with essential macromolecules, and allows excretion by the kidneys via urine. The extensive metabolism to glucuronide and sulfate conjugates during absorption is well described and decreases circulating levels of free trans-resveratrol. Thus, metabolism of resveratrol ultimately results in relatively small amounts of free trans-resveratrol in the plasma to be delivered to other tissues. Strategies to increase bioavailability from oral delivery of resveratrol are generally focused on increasing the rate of resveratrol absorption into the enterocytes and decreasing intracellular metabolism [40]. Further, the photostability of the resveratrol itself must also be considered when developing formulations, as resveratrol is sensitive to both heat and UV light. New approaches to increase the bioavailability of resveratrol can help to actualize its potentials as a therapeutic agent in DM and related complications.
\nDifferent approaches have been utilized by various researchers to increase the stability and bioavailability, some of which are discussed below.
\nOne simple approach to enhance bioavailability has been the consumption of resveratrol in combination with other phenolic compounds that play as the substrate for enzymes involved in resveratrol metabolism; such compounds which have demonstrated the positive effects are piperine, quercetin, etc. [41]. Combined effect of resveratrol along with curcumins was evaluated by Rouse et al. on animal models and human islet cell lines. Beneficial effects were demonstrated on insulin secretion by these naturally occurring polyphenols. However, the study revealed that the combination of resveratrol along with curcuminoids either did not yield any additional benefits or reduced the beneficial effects observed with the individual treatments. It would be noteworthy to test the combined effect of these two well-studied compounds on human models along with cinnamon and another known natural compound effective for diabetics. Further, clinical data are available on co-administration of resveratrol with various food and beverage, which contain subsequent amounts of other polyphenols such as grape juice, etc.; unfortunately, neither of these studies included a control condition to determine whether food or beverages enhanced or impaired bioavailability compared to resveratrol itself [41]. Due to 3-hydroxyl groups, resveratrol rapidly undergoes glucuronidation or sulphation. The presence of two methoxy groups in the pterostilbene structure makes it more lipophilic and thus more bioavailable and also more metabolically stable because it has only one free hydroxyl group available for glucuronidation or sulphation. However, the data also reveal that more the free hydrozyl groups, it shows better activity in in-vitro assays. Furthermore, administration of pterostilbene in a clinical trial at a dose of 125 mg twice daily for 6–8 weeks was found to be safe and did not evoke any remarkable adverse reactions. Still, there are no clinical studies on the antidiabetic effect of pterostilbene on diabetic patients and its co-treatment with resveratrol.
\nAnother approach to increase the absorption of resveratrol in the gastrointestinal tract is improving the material properties of resveratrol used in the oral dosage, given the rapid metabolism of resveratrol. This is the basis for SRT501, the patented formulation of micronized oral version of resveratrol that may have higher bioavailability. In this process, resveratrol is microionized to particle sizes <5 μm, mixed with flavorings, colorings, and emulsifying agents such as docusate sodium and mixed with water for ingestion. The small particle size with the emulsifiers in solution theoretically increases surface area for intestinal absorption while also improving suspension properties [42].
\nAnother approach to maximize the bioavailability of free trans-resveratrol is to develop resveratrol prodrugs, which could be used to improve the anti-diabetic efficacy of resveratrol. Assuming that maximizing free trans-resveratrol is the primary goal, resveratrol prodrug generates in vivo resveratrol through enzymatic reactions. Some of these technologies have been investigated in animal studies with no report in humans. Metabolism of prodrugs into resveratrol in tissues of interest can maximize tissue concentration and can be beneficial in the treatment of tissue specific complications in diabetic patients. Targeted delivery of resveratrol prodrugs into tissues of interest via delivery systems such as liposome-mediated delivery or nanotechnological approaches may result in the improved therapeutic effect. Also, intravenous injection as an option to the traditional oral route of administration of resveratrol may bypass gastrointestinal absorption, conjugation, and hepatic metabolism, therefore resulting in increased bioavailability and improved results in diabetic patients.
\nA routine of recent surveys have concentrated on applying nanotechnology to improve the bioavailability of resveratrol and have generally demonstrated improved stability and bioavailability with minimal side effects compared to oral dosing. Nanoformulations can improve resveratrol’s solubility and transport across the plasma membrane and therefore enhance its effects within cells.
\nThe nanoencapsulation methods include polylactic coglycolic acid nanoparticles [43, 44], carboxymethyl chitosan nanoparticles [45], solid lipid nanoparticles [46], and cyclodextrin nanoparticles [47]. Studies revealed sustained release profiles, which enhanced plasma bioavailability compared to free resveratrol. Nanoencapsulation was also effective in improving the solubility and stability of resveratrol. All the same, no clinical or paraclinical studies have been done to determine the efficacy of resveratrol nanovectors against antidiabetic potential.
\nNanovectors delivering resveratrol have been described by Singh and Pai that drew a sustained release of trans-resveratrol from orally administered polylactic-co-glycolic acid nanoparticles (drug encapsulation efficiency more than 78%, with a molecule size of about 170 NM) [43]. The same authors encapsulated resveratrol in Eudragit RL 100 nanoparticles with a drug incorporation efficiency of 84% and the average size of 180 nm. In vivo studies in a rat model showed prolonged plasma levels up to 16 h, in comparison with the free drug being cleared within 6 h [44]. Zu et al. developed carboxymethyl chitosan nanoparticles as a carrier for resveratrol [45]. These nanoparticles (155 nm-sized, with an encapsulation efficiency of 44%) improved the solubility of resveratrol, thereby greatly affecting the antioxidant activity of the drug. Additionally, resveratrol-loaded solid lipid nanoparticles were synthesized with a controlled release profile, due to an initial burst release of 40% caused by the active principle associated with the particle shell and a subsequent prolonged release of the drug located in the lipid matrix. In this system, the efficiency of the cellular uptake depended on the molecular interactions with the biological membrane organization, lipid rafts, and the actin cytoskeleton invaginations for the receptor-mediated entrance [48]. Resveratrol-loaded solid lipid nanoparticles have been also prepared by Pandita et al. with a drug incorporation efficiency of 89% and an average diameter of 134 nm [46]. This drug delivery system showed prolonged release in vitro up to 120 h in a Wistar rat model, enhancing plasma bioavailability compared to a free drug suspension. Finally, cyclodextrins-resveratrol complexes have been used to increase the concentration of polyphenol in aqueous solution while maintaining its biological activity. For example, spherical cyclodextrin-based nanosponges showed increasing solubility and stability, together with good drug encapsulation efficiency, compared to free resveratrol [48].
\nThere is a large body of evidence indicating resveratrol as an antidiabetic agent. Numerous studies have demonstrated that resveratrol can prevent, attenuate, or reverse diabetic dysfunction through diverse mechanisms and multiple molecular targets, which lead to pleiotropic therapeutic action in the whole organism. The exerted effects include inhibition of carbohydrate hydrolyzing enzymes (α-amylase and α-glucosidase) resulting in improved glycemic control, antioxidant properties, and antiinflammatory properties, which ultimately ameliorates diabetes and its complications. Resveratrol enhances insulin sensitivity and decreases insulin resistance, by changes in expression and activity of phosphodiesterases, kinases, AMPK, and SIRT1 in different tissues, which ultimately leads to protection of pancreatic β-cells from deterioration.
\nDespite widespread use of resveratrol as a nutritional supplement and the fact that animal models have provided a strong case for resveratrol as an antidiabetic agent, however, due to limited number of well-designed human clinical trials and various other limitations, this compound is still under investigation as an antidiabetic drug. The poor stability and bioavailability of resveratrol in humans have been a major concern for translating basic science findings into clinical utility [49].
\nFrom the 11 human clinical trial data available on effect of resveratrol as antidiabetic agent, all studies have shown positive effect of resveratrol in reducing the fasting plasma glucose level at higher concentration. But still there remain many discrepancies such as on the Hb1AC levels. The origins of these discrepancies are not definitively known but may be due to different quantification techniques (e.g., HPLC vs. MS/MS, etc.), different formulations and dosing protocols, and differing sample size, dosage duration, and effects of other drugs/materials used in combination with resveratrol. In addition, inter-bioavailability of resveratrol can vary from person to person, which may cause inconsistent physiological responses between individuals and limited clinical applicability. Thus, further well-defined clinical trials should exploit the efficacy of resveratrol itself or when used in combination with other antidiabetic drugs (e.g., metformin, etc.) or with other known antidiabetic natural products (curcumins, cinamaldedhye, etc.) as a potential pharmaceutical intervention.
\nA number of approaches have been developed to improve the stability and bioavailability of resveratrol, including consumption with various foods containing multiple polyphenols and micronized powders, combining it with additional phytochemicals, controlled release devices, and nanotechnological formulations. Animal studies demonstrate that these advanced formulations could improve tolerability in humans while also increasing its bioavailability; nonetheless, these nanotechnological and other advanced approaches are yet to be attempted in humans [41]. A combinational approach, as well as improved formulations of resveratrol, may help to overcome the challenge of maintaining an effective concentration at the site of action for an appropriate period, which needs to be confirmed by human studies.
\nAccording to Tannahill [1], health promotion is an umbrella term covering overlapping fields of health education, prevention and attempts to protect public health through social engineering, legislations, fiscal measures and institutional policies which entail the combination of the best in terms of both theory and practice from a wide range of expert groups (educationists, behavioral scientists, medical practitioners) and non-professionals including the communities involved. For him, health promotion stems largely from a new focus for health services that recognize some basic facts: many contemporary health problems are preventable or avoidable through lifestyle change; modern technology is a bundle of mixed blessings bringing both benefits and risks to health; medical technology is at the phase of diminishing returns (losing efficacy and connection to ordinary people); such non-medical factors as better nutrition, improved living conditions and public health measures have contributed to both health and longevity even more than medical measures; that doctors can cause as well as cure disease; and increasing public desire to attain better or improved quality of life and at the same time demystifying and demedicalising the attainment (achievement) of good health [1].
For the World Health Organization (WHO), health promotion is essentially about engendering a context in which the health and well-being of whole populations or groups are owned mainly by the people concerned, i.e., enabling citizens of local communities to achieve political control and determination of their health [2, 3]. Therefore, health promotion goes beyond mere healthcare but puts health on the policymaking agenda in all sectors and at all levels, directing policymakers to be cognisant or conscious of the health consequences of their decisions and accept responsibilities for health.
Health promotion can be seen as the whole process of enabling or empowering people to increase control over and improve their overall health. It focuses on creating awareness of health issues, engendering behaviour modification consistent with prevention and attitudes to ill health and motivating increased usage of available health facilities. In the pursuit of good health (physical, mental and social well-being), individuals and groups through health promotion are enabled to identify and realize aspirations, satisfy needs and change or cope with the environment in manners consistent with complete good health.
Health promotion is expected to contribute to programme impact by enabling prevention of disease, reduction of the risk factors or behaviors associated with given diseases, promoting and fostering lifestyles and conditions that are conducive to good health and enabling increasing use of available health facilities. Therefore, health promotion creates both the awareness and conscientisation that leads to disease prevention, control of health situations and usage of health services and facilities. It implies individual and collective control and participation in health focusing on behavioral change, socio-economic lifestyles and the physical environment.
Without doubt the WHO’s Ottawa Charter definition of health promotion is very comprehensive and encompasses the core values and guiding objectives of health promotions [3]. It summarily sees health promotion as the process of enabling people to increase control over and improve their health. In line with the above definition, Macdonald and Davies [4] contend that it calls attention to the critical role of the concepts of process and control as the real essence of health promotion. For them, “the key concepts in this definition are ‘process’ and ‘control’, and therefore effectiveness and quality assurance in health promotion must focus on enablement and empowerment. If the activity under consideration is not enabling and empowering it is not health promotion” [4], p. 6.
As the burgeoning literature on health promotion over the years indicate it is a community-driven (inspired), multifaceted and multidisciplinary area of concern that also involves critical sociopolitical, economic and environmental elements and dynamics (see [4, 5, 6, 7, 8, 9, 10]).
It is important to also understand that even though one can make a distinction between public health and health promotion, in reality both are interconnected and hardly practically separable. In other words, public health is built on health promotion and health promotion is imperative for public health delivery. As has been argued, public health “is synonymous with health promotion in that it aims to implement co-ordinated community action to produce a healthier society” [11], p. 315.
There is no gainsaying the fact that health promotion nowadays has an overwhelming sociopolitical component that is really definitive. In fact, as has been posited, “health promotion activities are by their nature inherently politically based and driven, thus making it impossible to divorce them from the political arena” [11], p. 314. Health promotion becomes a dynamic area of interface between public policy institutions (the state and its agencies), the public (community/people) and the professionals (ranging from the media professionals, public health advocates, social workers to medical practitioners).
The chapter depended on the desk review of extant literature and documents for its information. The main exclusionary criteria in this regard were materials not related to health promotion and materials published before 1984, which were considered extreme-dated. The inclusive criteria were determined by such concepts as public health, public health in Africa, health promotion, health education and awareness and theories and models in health promotion. Such prominent Internet information sites like the WHO, American Public Health Association (APHA), Health Resources and Services Administration (HRSA) and the Universitats Bibliothek Leipzig (UBL) Online Resources were utilized in gathering materials for the chapter.
There is no gainsaying the fact that effective and result-oriented health promotion practice depends on sound theory [12]. In other words, theory becomes very informative of health promotion practice and activities. In recognition of the above, one would examine briefly the main theories that have implicated health promotion globally. It is important, however, to state here that the choice of a theory or model to guide health promotion should be determined largely by the specific nature of the health issue being addressed, the community or population in view and the sociopolitical context in question. This is because theories and models are simply used in practice in order to plan health programmes, explain and understand health behaviour as well as underpin the identification of appropriate intervention and implement such intervention in ways that are both effective and sustainable.
Despite a plethora of theories and models utilized in health promotion, I will only focus on five of the most popular and commonly used. These are ecological models of health promotion, the Health Belief Model (HBM), Stages of Change Model or the Trans-theoretical Model, Theory of Reasoned Action or Planned Behaviour and the Social Cognitive Theory.
As the name implies, these models focus on the interaction of people with their physical and sociocultural environments. The approach thus recognizes that there are multiple levels of influence on health and health behaviour especially the health seeking behaviour and choices that people make. The ecological models are anchored on five overriding influences which determine and guide health behaviour and response to health issues [13, 14, 15, 16]. These influences are intrapersonal or individual factors (these impact on individual behaviour, e.g., beliefs, knowledge, attitude, etc.); interpersonal factors (these are produced through living with and interacting with other people, e.g., family, friends and social groups/networks; these other people can function as both the source of solidarity and support as well as sources of barriers and constraints to health-promoting behaviour of the individual, e.g., dwelling among chronic smokers or having intense interaction with them may expose one to the dangers of either smoking or the influence of second-hand smoke); community factors (these make reference to social norms that are shared by groups or communities, and such norms whether formal or informal can influence health behaviour and health seeking behaviour of the individual and group members, e.g., relationship between institutions, groups and organizations); institutional factors (policies, rules, regulations and institutional structures that may constrain or even promote healthy behaviour in a given society, e.g., the workplace and voluntary organizations to which the individual belongs are prime examples); public policy factors (policies at different level of governance that regulate, structure or support actions and practices targeted at health outcomes like disease prevention policies and structures enabling early detection, control or response and management of health crisis in the society; these stem from the position of the government and are critical in achieving the goals of public health delivery) (Figure 1).
Ecological models of health promotion (simplified).
As the above pyramid, suggests the individual, interpersonal and community factors are at the base. These factors therefore exert more influence and pressure over the individual’s health behaviour than the institutional and public policy factors as these are more important. In other words, the institutional and public policy factors are literally far from the individual and do not exert as much pressure on his behaviour as those factors that are very close to him both spatially and otherwise. In an age of increasing pessimism in government, people are much driven by interpersonal and community factors than what comes from a typical further off entity.
Given the above, it is obvious that the ecological approach is very pertinent in the understanding of the range of factors that influence people’s health. Its main strength is that it can provide what is called a complete perspective on factors that affect health behaviour and response to health issues especially the role of social and cultural factors or normative patterns on health in the society. It is perhaps very well suited to health intervention and practice in developing societies with an overbearing influence of sociocultural factors on behaviour, attitudes and practice of the people.
This is a theoretical model that has been found useful in guiding both health promotion and strategies for disease prevention. As the name suggests, it focuses on individual beliefs about specific health conditions which predict or direct individual health behaviour [17, 18]. The specific components of this belief that influence health behaviour include perceived susceptibility to the disease; perceived severity of the disease in question; perceived benefits of action (positive benefits of such action) as well as cues to action (awareness of factors that engender action); self-efficacy (belief that action would lead to success); and perceived barriers or obstacles to action (especially if such obstacles are seen as daunting or insurmountable or otherwise).
In the utilization of the HBM in health promotion, there are five main action-related segments that would help in identifying key decision-making points and thus facilitate the utilization of knowledge in guiding health intervention. These are: collection of information (through needs assessments; rapid rural appraisal, etc. in order to determine those at risk of the disease or affliction and specify which population or component of the population to be targeted in the intervention); conveying in unambiguous and clear terms the likely consequences of the health issue in question and its associated risk behaviors in order to facilitate a clear apprehension of its severity; communication (getting information to the target population on the recommended steps to take and the perceived or likely benefits of the recommended action); provision of needed assistance (help the people in both the identification of and reduction of barriers or constraints to action); and demonstration (actions and activities that enable skill development and support aimed at enhancing self-efficacy and increased chances of successful behaviour modification targeted at the health issue in question) (Figure 2).
Health belief model (HBM).
In Africa, the HBM has been very useful in understanding people’s response and behaviour to HIV/AIDS and other chronic diseases. Being a society very flushed with beliefs, the degree of responsiveness to a health situation is often the direct product of a set of beliefs held by the individual and/or by his immediate community.
This model is focused on examining and explaining the individual’s readiness to change his behaviour and sees such change as occurring or happening in successive stages. It therefore adopts a quasi-evolutionary framing of behaviour change in which behaviour change, sustenance and termination are encompassed in six stages. These stages are pre-contemplation (existence of no intention to take any action by the individual); contemplation (thinking about taking action and ruminating on plans to do this soon); preparation (signifies intention to take action and includes the possibility that some steps or preliminary steps to action have been taken already); action (discernible change in behaviour for a brief period of time); maintenance (sustenance of the action taken; behaviour change that is maintained in the long run or long-term behaviour change); and termination (the expressed and discernible desire never to return to prior negative behaviour by the individual concerned).
The above stages are very important in planning behaviour change or modification and recognize that behaviour change is both gradual and takes time. What is needed from the health promoter is that at each of these stages specific interventions or programmes are devised to help the individual progress to the next stage. Also, the recognition that the model may in reality be cyclical rather than lineal, i.e., individuals may progress to the next stage or even regress to previous or lower stages, is important in planning health promotion interventions utilizing this model. It also calls attention to understanding that there are individual differences in the adoption of change, i.e., some people may be swift in behaviour modification, while others may take longer time; but each needs support in order to pull through.
The main contention of this theory is that an individual’s health behaviour is usually determined by his intention to exhibit or display a given behaviour. Therefore, the intention to exhibit a given behaviour (or behaviour intention) is predicated upon or predicted by two main factors, viz. personal attitude to the behaviour in question and subjective or personal norms (an individual’s social and environmental context and the perception the individual has over that behaviour) related to that behaviour.
The basic assumption here is that both positive attitudes and positive subjective norms will generate greater perceived control of behaviour and increase the chances of intentions towards changes in behaviour. The theory generally provides information that can be used in predicting people’s health behaviour and thus in planning and driving through health interventions. It anchors in recognizing the predictors of behaviour-oriented action and the need for supportive social and environmental contexts that facilitate and sustain desirable health behaviour.
This theory combines both the cognition of the individual and the social context of the individual in offering explanation and understanding of health behaviour and response. It seeks to describe the influence of the experience of the individual, his perception of the actions of other people near him and the factors in the person’s immediate environment on health behaviour of the individual. It moves from this general perspective to provide opportunities for social support (defined as conducive to healthy behaviour) and reinforcements that generate behaviour change or modification. In this sense, the SCT depends on the idea of reciprocal determinism which denotes the continuing or uninterrupted interaction among the person’s characteristics, his behaviour and the social context or environment in which the behaviour takes place.
However, the best way to appreciate the SCT is to examine the main components the theory isolates as related to behaviour change at the individual level. These are self-efficacy (belief in one’s ability to control and execute behaviour within a given context); behaviour capability (thorough comprehension of behaviour and the ability to exhibit or perform it); expectations (outcomes or outputs of the behaviour change in question); expectancies (the assignation of value to the above outcome of behaviour and which is important in sustaining the behaviour); self- control (the regulation and monitoring of behaviour of the individual); observational learning (the act of watching others performing the desired behaviour and the outcomes therein as well as modeling that behaviour in question); and reinforcements (incentives and rewards seen as eliciting, encouraging and sustaining behaviour change in the individual) [19].
The three components as the above diagram shows reinforce each other and in the process condition and determine behaviour of the individual even in the context of health as well as choices made therein (Figure 3). The SCT is very pertinent in contexts where desirable health outcomes can be achieved by behaviour modification or change. For instance, certain chronic diseases or health conditions can be tackled through healthy lifestyles and dieting that reduce risk factors and chances of individuals succumbing to such conditions. Therefore, the theory can help frame intervention programmes in this area that focus on changing people’s behaviour and in the process achieve desirable health outcomes.
Illustration of the social cognitive theory (SCT).
Theories and perspectives or models as already indicated are critical in providing explanations of a problem or issue (broadening our understanding and perspective as it were) and also very important in the effort to tackle a given problem or issue in the society especially by way of developing and implementing programmes and interventions. Perhaps, the above underscores why some scholars [20, 21, 22] would highlight the difference between the so-called theories of the problem and theories of action, meaning that while the former aids our apprehension of a given issue or social reality, the latter is important in terms of taking actions or evolving activities to tackle the issue in question.
Health promotion generally implicates a huge element of politics and power dynamics in the sense that only political will and cognition can build discernible changes in health. Lobbying and advocacy are critical tools of health promotion and function within the political arena. The sociopolitical contexts and influences are especially recognizable in the public health sector in the developing world where political will and doggedness are often necessary to drive through even the most salutary change or innovation in the health sector. Also, political forces are equally dominant in the provision of crucial health infrastructure and facilities as well as the reasonable funding demanded by any effective public health system. As Harrison opines health promotion “requires concerted, sophisticated and integrated political action to bring about change and requires professionals concerned with public health to engage with the politics of systems and organizations” [5], 165.
Therefore, health promotion seeks to empower and transform communities by getting them involved in activities that influence public health especially through agenda setting, lobbying and advocacy, consciousness raising and social education [11, 22]. All these are accomplished on terms that are either defined or strictly affected by the socio-economic realities of the people themselves. By its emphasis on the community, health promotion has a heavy sociological frame that prioritizes the values of society as well as mobilization and solidarity in the quest for good and sustainable health. It thus makes assumption that individual members of the society would give equal weight to their own health and the health of their neighbors. In other words, it is often anchored on the uncanny assumption that the health of the individual member of a given society is intertwined with the health of the community as a collective. This means the reference point of health promotion is that one’s health is as good as the health of the members of the community or society as a whole, i.e., common health destiny. Therefore, such things as community empowerment, community competence and overwhelming sense of community are all apprehended as contributing to the health of the communities [23].
Traditionally there are five approaches utilized in health promotion. These are medical (the focus here is to make people free from medically defined diseases and afflictions; it is mainly anchored on prevention strategies and the role of the medical practitioner or expert in ensuring that the patients comply with recommendations); behavioural change (behaviour modification approach that recognizes that people’s behaviour and lifestyles can be changed in order to enable them attain good health, i.e., facilitate adoption of healthy lifestyle); educational (provision of information and knowledge that enable understanding of health issues and build awareness for informed decision-making and choice among people); client-centred (in this situation health practitioners work with clients in order to identify what they know about a given disease and take appropriate action; emphasis on perceiving the client as equal and building the clients self-empowerment that enable them make good choices and control their health outcomes); and societal change (the focus here is on the society or community rather than the individual and seeks to change or modify both the physical and social environments in order to make them consistent with or conducive to good health).
The conventional health promotion methods (modes of operationalizing health promotion and achieving its goals) include health education (the conscious and systematic effort at providing education or knowledge to people on particular and general aspects of health; it is about enabling people through proper and right knowledge on what to do and how to do it; it is empowering and improving people’s capacity to act with regard to their health issues and conditions), information, communication (the above three are often captured in the popular acronym IEC), social mobilization, mediation, community theater and advocacy and lobbying. However, while these methods are okay in differing contexts, a decision on the specific medium to use should be guided by both environment (community conditions) and the nature of the health issue involved. The use of more than one method in any given case is highly recommended especially in Africa where there are broad inequalities in access to social goods and the media. The increasing use of social media especially among young Africans calls attention to their deployment equally in core health promotion. Social media platforms like WhatsApp and blogs can be very potent in this regard.
There is an undeniable need to give high priority to health promotion research in Africa. Such research should aim at enabling a realistic and focused achievement of the goals of health promotion. Broadly, health promotion aims inter alia at:
The prevention of communicable and non-communicable diseases
The reduction of risk factors associated with diseases
The fostering of lifestyles and conditions in the general population that are consistent with overall well-being or good health
The effective/maximal utilization of existing health services and stimulating demand for others where/when necessary
According to the WHO [24] Health Promotion Strategy for the African Region, the contributions of health promotion to the achievement of health objectives include increasing individual knowledge and skills especially through IEC; strengthening community action through the use of social mobilization; enabling the emergence of environments supportive and protective of health by making optimal use of mediation and negotiation; enabling the development of public policies, legislation and fiscal controls which enhance and support health and overall development using advocacy and lobbying; and making prevention and consumer needs the core focus of health services delivery. All these can be positively influenced by research and studies which evaluate the effectiveness of what has been done as well as explore new strategies suitable to the socio-environmental context in question.
However, while research is very critical to achieving the goals of health promotion, it should be concise and focus essentially on the priority health programmes which have been identified by the WHO for the continent. Some of such programmes include the Global Fund for Malaria, HIV/AIDS and Tuberculosis, Immunization, Mental Health, the Tobacco Free Initiative and Reproductive Health as well as the fight against recurrent scourge of Ebola, etc. Such research should focus on identifying effective health promotion approaches and communication media to embody and convey the outcomes to communities through community participation; the extent or effectiveness of these means and seeking to still improve overall programme effectiveness and sustainability. Therefore, health promotion research should focus on ascertaining goals/outcomes of health promotion (to guide policy), provide reliable conditions associated with these outcomes or goals, precisely define the changes intended and delineate reliable mechanisms and indicators of M and E of health promotion strategies in specific country/community contexts.
The importance of research is essentially derived from the fact that it calls attention to the need for verification and evidence-based activities in health promotion. These are without doubt the ways of knowing if real empowerment and enabling has been achieved in the process. Thus,
Health promotion is about enabling people to improve their health; and secondly, evidence relevant to health promotion should bear directly on factors that support or prevent enablement and empowerment (determinants of health) activities that support enablement and empowerment (health promotion) and assessing whether these activities have been successful (evaluation of health promotion). [25], p. 357
The above clearly suggest that health promotion should be anchored on evidence or should rest on experience and reality regarding what works or what is possible and effective in any context. In this manner, “evidence-based health promotion involves explicit application of quality research evidence when making decisions” [26], p. 126. Research is even more foundational in health promotion since health promotion efforts need to be anchored on agreed definitions and values of health promotion. As Seedhouse contends the failure to be explicit about definitions and values generates conceptual confusion in research as well as sloppy practice [27].
The evaluation of health promotion which should be a core research activity may be based on the three main forms of evidence/knowledge associated with health promotion [28]: instrumental (controlling social and physical environments), interactive (understanding of diseases/health issues; lived experiences; solidarity) and critical (reflection and action; raising consciousness regarding causes and means of overcoming them). These three evidences are anchored on the given scientific/philosophical traditions, viz. instrumental (positivism, quantitative, experimental, scientific knowledge), interactive (constructivist, naturalistic, ethnographic/qualitative knowledge) and critical (materialist, structural and feminist theory).
There is also an overwhelming need for health promotion research to be aware of the difference between health promotion outcomes and health outcomes. Health outcomes crudely imply the consequences or benefits of healthcare delivery (e.g., reduction of mortality rate) related to a disease (which may be the case in spite of an increment in number of those affected by the disease). But health promotion outcomes signify the form of control and attitudinal re-orientation groups and individuals adopt in facing a given disease which may impact on the number of people affected by the disease and improve attitudes and behaviour towards those affected by the disease. Health promotion outcomes can be seen directly through community members’ perception and interpretations of a given health issue which makes the achievement of control possible.
Health promotion research should utilize both quantitative and qualitative methods. In addition to complementing quantitative methods in health promotion research, qualitative research enables the researcher reach the heart of issues in engagement with community members. In Africa, where a good percentage of the population are still domiciled in the rural areas, qualitative approach offers the possibility of profound insights into the why and how of health behaviors which may not be possible or easily achieved with the quantitative or traditional biomedical approaches. As a result, “the increasing popularity of qualitative methods is as a result of perceived failure of traditional methods to provide insights into the determinants – both structural and personal – of whether people pursue or do not pursue health-promoting actions” [25], p. 359.
It is important to recognize that in spite of apparent good intentions, health promotion can actually generate negative or counterproductive effects when not well managed. Thus, “negative outcomes occur where professionally paternalistic and disempowering health policy decisions force health-related outcomes that are irrelevant to sustained community development and are not based on or resourced according to the social reality of the community” [11], p. 315. The above sentiments caution one against embarking on health promotion activities and initiatives that are not anchored on the health realities of the community concerned. Often, overzealous health professionals unintentionally betray the health priorities of communities by assuming knowledge of all there is to know about the health situations and needs of the people.
Perhaps a critical shortfall of some health promotion activities and processes is the adoption of what can be termed the pathogenic paradigm which over-relies on risk instead of emphasizing protective mechanisms. This essentially entails a focus on the failure of communities and individuals to avoid disease or their apparent susceptibility to diseases instead of seeking to unleash their potential and capacity to engender and sustain good health and development. It is an approach that relies too much on health practitioners and experts and hardly gives voice to the people and their own knowledge cum realities.
Generally health promotion in Africa suffers from some of the debilitating challenges which confront the practice of health promotion broadly in many countries in the continent. These challenges, among others, include:
Poor definition and rudimentary elaboration of expected health outcomes
Ambiguous elaboration of factors and conditions to be targeted in health promotions
Ambiguity of health promotion policies and guidelines
Lack of capacity (or inadequate capacity) to develop, implement and evaluate health promotion programmes
A general context of inadequate investment in health promotion
Underdeveloped sectoral collaboration
Low political will and commitment to health promotion programmes as well as institutional corruption and resource mismanagement
The above challenges have implications for research in health promotions in the continent. There is no gainsaying the need for health promotion to be evidence based because essentially it is the only way to make it responsive to the health needs and interests of the people.
Health promotion combines varied but complementary indicators like legislation, health finance including fiscal measures and taxation, gender inclusiveness, mapping of priorities and organizational change. In spite of their differences, these issues are in reality intertwined or systematically connected in the sense that, for the public health system to function well and optimally, there should be a synergy between these indicators. Briefly:
This revolves around having the political will to make and drive through policies and laws that improve and sustain healthcare delivery. It also involves public health sector governance and leadership which aim at ensuring that only competent and qualified people lead the sector and that activities are governed by a democratic and free process which place emphasis on human rights, dignity and self-worth of all stakeholders.
Without doubt efficient health promotion and by implication the entire health delivery system cannot function without finance. In fact, the extent and impact of health promotion depend to a significant extent on the availability of funds. The problem of finance is especially critical in developing nations in Africa where political corruption and competing needs whittle down whatever gets to health from the yearly appropriation of government. However, there is a need to understand that a lot needs to be done in terms of the fiscal policies in these nations in order to achieve the desire for good health and improved life expectancy. In other words, the process of fiscal policymaking and budgetary allocation should prioritize health promotion and health delivery in these countries.
There is no gainsaying the fact that the health system as a whole is dynamic especially so in Africa where apart from battling known ailments new ones (or novel presentation of the old ailments) spring up now and then. The above entails that the health system calls for dynamic organizational setting that is robust enough to deal with changes while making improvements in the system. There is apparently no denying the fact that health promotion as a critical component of health delivery would benefit from organizational change. This is particularly so in the face of the reality that health promotion in most of the continent is still below the expectation. This is not to deny that health promotion has worked well in specific instances like the HIV/AID scourge and maternal health. However, such grab and slash system which focuses on only one of such delimited issues in the system cannot be seen as either robust or effective in the long run.
There is an obvious need to ‘en-gender’ health promotion as a very critical issue in Africa. This would entail ensuring that those involved in health promotion ensure that in all key phases of health promotion (planning, implementation and evaluation) women and men should be equal partners and collaborators. Gender, in this case, while calling attention to the needs of women, should also ensure that the men are not left behind even in approaching health issues traditionally seen as the concerns of women. Typical example here is in the area of family planning or reproductive health which demands the active collaboration or participation of both men and women to achieve desired results.
For the WHO [24], the priority interventions in Africa in respect of health promotions include capacity building, development of plans, incorporation of health promotion components in non-health sectors and strengthening of priority programmes using health promotion interventions. These essentially mean pursuing health promotion through capacity building, action planning, advocacy and multisectoral orientation. They are also in tune with relating to the determinants of health promotion in the continent. These include socio-economic conditions and physical (environment), biological, and behavioral lifestyles which impact on health in Africa. Countries can be encouraged to map out their priorities taking into consideration such factors as disease and financial burdens, threats, intervention tools and agencies, acuity, management capabilities, persistent challenges, etc.
Generally, there is a need for stepping up health promotion research in Africa in the areas of family and reproductive health targeting such issues as VVF, antenatal care, diabetes, cardiovascular issues, new disease forms/resurgence of old diseases (including Ebola), etc. especially in terms of communicating with those who are marginal to the formal sector of the society or who are less privileged by virtue of education, economic opportunities or physical/mental challenges, etc. in both urban and rural contexts. Health promotion can profit from an acute awareness of the fact that what works in one socio-geographical setting may not work in another since no two societies are exactly the same. This would entail designing programmes that even where the general principles or goals remain the same embody recognition of the socio-geographical peculiarities of the society/community concerned.
Given the usual paucity of funds in the continent, it makes sense that to minimize cost and save time, there should be incorporation of both needs assessment and evaluation into ongoing health promotion activities. This approach offers a smart way of pursuing health promotion goals without elaborate budget.
In spite of country differences and specific structural challenges, there is a need to build a culture of sharing and documenting outcomes and evidences of health promotion between different countries and organizations. This is a step towards achieving the desirable goal of multinational coordination especially for infectious diseases and epidemics. Equally, African nations need to invest more in capacity building for media and theater practitioners in both private and public sectors on health promotion. There is no gainsaying the media’s crucial role in health information dissemination. Actually, health promotion is largely media driven and should be programmed as such.
In addition to media practitioners, there should be health programme or intervention specific to health promotion capacity building for different cadres of public sector workers. Such capacity building or training should be anchored on acute awareness of current research trends and best practices globally. There should also be increased attention to the need for specific health promotion for under-represented health issues and priority to non-communicable diseases should be targeted. It should also improve capacity on how to incorporate methods of targeting members of the society marginal or vulnerable within each country context.
.
",metaTitle:"Order Print Copies - Terms",metaDescription:".",metaKeywords:null,canonicalURL:"page/order-print-copies-terms/",contentRaw:'[{"type":"htmlEditorComponent","content":"Orders have to be prepaid in advance and before printing. We accept payment in GBP, EUR and USD. Payments can be made by bank transfer or cheque, by credit card (Visa, MasterCard, American Express, Discover Card) and PayPal worldwide online payments system. In accordance with the best security practice, we do not accept card orders via email.
\\n\\nThe combined printing and delivery times for orders vary from 12-20 business days, depending on the printed quantity and destination. This period does not include any customs clearance difficulties that may arise and that are beyond our control. Once your order has been printed and shipped, you will receive a confirmation email that includes your DHL tracking number. You can then track your order at www.dhl.com.
\\n\\nMy order has not arrived, what do I do?
\\n\\nIf you do not receive your order within 30 days, please contact us to inquire about the shipping status at orders@intechopen.com.
\\n\\nPOD products are non-returnable and non-refundable, except in the event of poor print quality or an error in quantity. If we delivered the item to you in error or the item is faulty, please contact us. Inspect your order carefully when it arrives. Any problems should be immediately reported to orders@intechopen.com.
\\n\\nTaxes: Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing us their VAT registration number. This is made possible by the EU reverse charge method.
\\n\\nCustoms: Shipping costs do not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Orders have to be prepaid in advance and before printing. We accept payment in GBP, EUR and USD. Payments can be made by bank transfer or cheque, by credit card (Visa, MasterCard, American Express, Discover Card) and PayPal worldwide online payments system. In accordance with the best security practice, we do not accept card orders via email.
\n\nThe combined printing and delivery times for orders vary from 12-20 business days, depending on the printed quantity and destination. This period does not include any customs clearance difficulties that may arise and that are beyond our control. Once your order has been printed and shipped, you will receive a confirmation email that includes your DHL tracking number. You can then track your order at www.dhl.com.
\n\nMy order has not arrived, what do I do?
\n\nIf you do not receive your order within 30 days, please contact us to inquire about the shipping status at orders@intechopen.com.
\n\nPOD products are non-returnable and non-refundable, except in the event of poor print quality or an error in quantity. If we delivered the item to you in error or the item is faulty, please contact us. Inspect your order carefully when it arrives. Any problems should be immediately reported to orders@intechopen.com.
\n\nTaxes: Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing us their VAT registration number. This is made possible by the EU reverse charge method.
\n\nCustoms: Shipping costs do not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/55578/images/4574_n.png",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:5775},{group:"region",caption:"Middle and South America",value:2,count:5238},{group:"region",caption:"Africa",value:3,count:1721},{group:"region",caption:"Asia",value:4,count:10409},{group:"region",caption:"Australia and Oceania",value:5,count:897},{group:"region",caption:"Europe",value:6,count:15805}],offset:12,limit:12,total:118374},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{sort:"dateendthirdsteppublish"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:18},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:5},{group:"topic",caption:"Business, Management and Economics",value:7,count:2},{group:"topic",caption:"Chemistry",value:8,count:8},{group:"topic",caption:"Computer and Information Science",value:9,count:5},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:7},{group:"topic",caption:"Engineering",value:11,count:19},{group:"topic",caption:"Environmental Sciences",value:12,count:2},{group:"topic",caption:"Immunology and Microbiology",value:13,count:3},{group:"topic",caption:"Materials Science",value:14,count:5},{group:"topic",caption:"Mathematics",value:15,count:1},{group:"topic",caption:"Medicine",value:16,count:24},{group:"topic",caption:"Neuroscience",value:18,count:2},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:3},{group:"topic",caption:"Physics",value:20,count:3},{group:"topic",caption:"Psychology",value:21,count:4},{group:"topic",caption:"Robotics",value:22,count:1},{group:"topic",caption:"Social Sciences",value:23,count:3},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:1}],offset:0,limit:12,total:null},popularBooks:{featuredBooks:[{type:"book",id:"9521",title:"Antimicrobial Resistance",subtitle:"A One Health Perspective",isOpenForSubmission:!1,hash:"30949e78832e1afba5606634b52056ab",slug:"antimicrobial-resistance-a-one-health-perspective",bookSignature:"Mihai Mareș, Swee Hua Erin Lim, Kok-Song Lai and Romeo-Teodor Cristina",coverURL:"https://cdn.intechopen.com/books/images_new/9521.jpg",editors:[{id:"88785",title:"Prof.",name:"Mihai",middleName:null,surname:"Mares",slug:"mihai-mares",fullName:"Mihai Mares"}],equalEditorOne:{id:"190224",title:"Dr.",name:"Swee Hua Erin",middleName:null,surname:"Lim",slug:"swee-hua-erin-lim",fullName:"Swee Hua Erin Lim",profilePictureURL:"https://mts.intechopen.com/storage/users/190224/images/system/190224.png",biography:"Dr. Erin Lim is presently working as an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates and is affiliated as an Associate Professor to Perdana University-Royal College of Surgeons in Ireland, Selangor, Malaysia. She obtained her Ph.D. from Universiti Putra Malaysia in 2010 with a National Science Fellowship awarded from the Ministry of Science, Technology and Innovation Malaysia and has been actively involved in research ever since. Her main research interests include analysis of carriage and transmission of multidrug resistant bacteria in non-conventional settings, besides an interest in natural products for antimicrobial testing. She is heavily involved in the elucidation of mechanisms of reversal of resistance in bacteria in addition to investigating the immunological analyses of diseases, development of vaccination and treatment models in animals. She hopes her work will support the discovery of therapeutics in the clinical setting and assist in the combat against the burden of antibiotic resistance.",institutionString:"Abu Dhabi Women’s College",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Perdana University",institutionURL:null,country:{name:"Malaysia"}}},equalEditorTwo:{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai",profilePictureURL:"https://mts.intechopen.com/storage/users/221544/images/system/221544.jpeg",biography:"Dr. Lai Kok Song is an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates. He obtained his Ph.D. in Biological Sciences from Nara Institute of Science and Technology, Japan in 2012. Prior to his academic appointment, Dr. Lai worked as a Senior Scientist at the Ministry of Science, Technology and Innovation, Malaysia. His current research areas include antimicrobial resistance and plant-pathogen interaction. His particular interest lies in the study of the antimicrobial mechanism via membrane disruption of essential oils against multi-drug resistance bacteria through various biochemical, molecular and proteomic approaches. Ultimately, he hopes to uncover and determine novel biomarkers related to antibiotic resistance that can be developed into new therapeutic strategies.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Higher Colleges of Technology",institutionURL:null,country:{name:"United Arab Emirates"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10020",title:"Operations Management",subtitle:"Emerging Trend in the Digital Era",isOpenForSubmission:!1,hash:"526f0dbdc7e4d85b82ce8383ab894b4c",slug:"operations-management-emerging-trend-in-the-digital-era",bookSignature:"Antonella Petrillo, Fabio De Felice, Germano Lambert-Torres and Erik Bonaldi",coverURL:"https://cdn.intechopen.com/books/images_new/10020.jpg",editors:[{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9560",title:"Creativity",subtitle:"A Force to Innovation",isOpenForSubmission:!1,hash:"58f740bc17807d5d88d647c525857b11",slug:"creativity-a-force-to-innovation",bookSignature:"Pooja Jain",coverURL:"https://cdn.intechopen.com/books/images_new/9560.jpg",editors:[{id:"316765",title:"Dr.",name:"Pooja",middleName:null,surname:"Jain",slug:"pooja-jain",fullName:"Pooja Jain"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10192",title:"Background and Management of Muscular Atrophy",subtitle:null,isOpenForSubmission:!1,hash:"eca24028d89912b5efea56e179dff089",slug:"background-and-management-of-muscular-atrophy",bookSignature:"Julianna Cseri",coverURL:"https://cdn.intechopen.com/books/images_new/10192.jpg",editors:[{id:"135579",title:"Dr.",name:"Julianna",middleName:null,surname:"Cseri",slug:"julianna-cseri",fullName:"Julianna Cseri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9243",title:"Coastal Environments",subtitle:null,isOpenForSubmission:!1,hash:"8e05e5f631e935eef366980f2e28295d",slug:"coastal-environments",bookSignature:"Yuanzhi Zhang and X. San Liang",coverURL:"https://cdn.intechopen.com/books/images_new/9243.jpg",editors:[{id:"77597",title:"Prof.",name:"Yuanzhi",middleName:null,surname:"Zhang",slug:"yuanzhi-zhang",fullName:"Yuanzhi Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9385",title:"Renewable Energy",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"a6b446d19166f17f313008e6c056f3d8",slug:"renewable-energy-technologies-and-applications",bookSignature:"Tolga Taner, Archana Tiwari and Taha Selim Ustun",coverURL:"https://cdn.intechopen.com/books/images_new/9385.jpg",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:{id:"186791",title:"Dr.",name:"Archana",middleName:null,surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari",profilePictureURL:"https://mts.intechopen.com/storage/users/186791/images/system/186791.jpg",biography:"Dr. Archana Tiwari is Associate Professor at Amity University, India. Her research interests include renewable sources of energy from microalgae and further utilizing the residual biomass for the generation of value-added products, bioremediation through microalgae and microbial consortium, antioxidative enzymes and stress, and nutraceuticals from microalgae. She has been working on algal biotechnology for the last two decades. She has published her research in many international journals and has authored many books and chapters with renowned publishing houses. She has also delivered talks as an invited speaker at many national and international conferences. Dr. Tiwari is the recipient of several awards including Researcher of the Year and Distinguished Scientist.",institutionString:"Amity University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},equalEditorTwo:{id:"197609",title:"Prof.",name:"Taha Selim",middleName:null,surname:"Ustun",slug:"taha-selim-ustun",fullName:"Taha Selim Ustun",profilePictureURL:"https://mts.intechopen.com/storage/users/197609/images/system/197609.jpeg",biography:"Dr. Taha Selim Ustun received a Ph.D. in Electrical Engineering from Victoria University, Melbourne, Australia. He is a researcher with the Fukushima Renewable Energy Institute, AIST (FREA), where he leads the Smart Grid Cybersecurity Laboratory. Prior to that, he was a faculty member with the School of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. His current research interests include power systems protection, communication in power networks, distributed generation, microgrids, electric vehicle integration, and cybersecurity in smart grids. He serves on the editorial boards of IEEE Access, IEEE Transactions on Industrial Informatics, Energies, Electronics, Electricity, World Electric Vehicle and Information journals. Dr. Ustun is a member of the IEEE 2004 and 2800, IEC Renewable Energy Management WG 8, and IEC TC 57 WG17. He has been invited to run specialist courses in Africa, India, and China. He has delivered talks for the Qatar Foundation, the World Energy Council, the Waterloo Global Science Initiative, and the European Union Energy Initiative (EUEI). His research has attracted funding from prestigious programs in Japan, Australia, the European Union, and North America.",institutionString:"Fukushima Renewable Energy Institute, AIST (FREA)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Institute of Advanced Industrial Science and Technology",institutionURL:null,country:{name:"Japan"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8985",title:"Natural Resources Management and Biological Sciences",subtitle:null,isOpenForSubmission:!1,hash:"5c2e219a6c021a40b5a20c041dea88c4",slug:"natural-resources-management-and-biological-sciences",bookSignature:"Edward R. Rhodes and Humood Naser",coverURL:"https://cdn.intechopen.com/books/images_new/8985.jpg",editors:[{id:"280886",title:"Prof.",name:"Edward R",middleName:null,surname:"Rhodes",slug:"edward-r-rhodes",fullName:"Edward R Rhodes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10065",title:"Wavelet Theory",subtitle:null,isOpenForSubmission:!1,hash:"d8868e332169597ba2182d9b004d60de",slug:"wavelet-theory",bookSignature:"Somayeh Mohammady",coverURL:"https://cdn.intechopen.com/books/images_new/10065.jpg",editors:[{id:"109280",title:"Dr.",name:"Somayeh",middleName:null,surname:"Mohammady",slug:"somayeh-mohammady",fullName:"Somayeh Mohammady"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9644",title:"Glaciers and the Polar Environment",subtitle:null,isOpenForSubmission:!1,hash:"e8cfdc161794e3753ced54e6ff30873b",slug:"glaciers-and-the-polar-environment",bookSignature:"Masaki Kanao, Danilo Godone and Niccolò Dematteis",coverURL:"https://cdn.intechopen.com/books/images_new/9644.jpg",editors:[{id:"51959",title:"Dr.",name:"Masaki",middleName:null,surname:"Kanao",slug:"masaki-kanao",fullName:"Masaki Kanao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9550",title:"Entrepreneurship",subtitle:"Contemporary Issues",isOpenForSubmission:!1,hash:"9b4ac1ee5b743abf6f88495452b1e5e7",slug:"entrepreneurship-contemporary-issues",bookSignature:"Mladen Turuk",coverURL:"https://cdn.intechopen.com/books/images_new/9550.jpg",editors:[{id:"319755",title:"Prof.",name:"Mladen",middleName:null,surname:"Turuk",slug:"mladen-turuk",fullName:"Mladen Turuk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9027",title:"Human Blood Group Systems and Haemoglobinopathies",subtitle:null,isOpenForSubmission:!1,hash:"d00d8e40b11cfb2547d1122866531c7e",slug:"human-blood-group-systems-and-haemoglobinopathies",bookSignature:"Osaro Erhabor and Anjana Munshi",coverURL:"https://cdn.intechopen.com/books/images_new/9027.jpg",editors:[{id:"35140",title:null,name:"Osaro",middleName:null,surname:"Erhabor",slug:"osaro-erhabor",fullName:"Osaro Erhabor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8558",title:"Aerodynamics",subtitle:null,isOpenForSubmission:!1,hash:"db7263fc198dfb539073ba0260a7f1aa",slug:"aerodynamics",bookSignature:"Mofid Gorji-Bandpy and Aly-Mousaad Aly",coverURL:"https://cdn.intechopen.com/books/images_new/8558.jpg",editors:[{id:"35542",title:"Prof.",name:"Mofid",middleName:null,surname:"Gorji-Bandpy",slug:"mofid-gorji-bandpy",fullName:"Mofid Gorji-Bandpy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:5247},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9521",title:"Antimicrobial Resistance",subtitle:"A One Health Perspective",isOpenForSubmission:!1,hash:"30949e78832e1afba5606634b52056ab",slug:"antimicrobial-resistance-a-one-health-perspective",bookSignature:"Mihai Mareș, Swee Hua Erin Lim, Kok-Song Lai and Romeo-Teodor Cristina",coverURL:"https://cdn.intechopen.com/books/images_new/9521.jpg",editors:[{id:"88785",title:"Prof.",name:"Mihai",middleName:null,surname:"Mares",slug:"mihai-mares",fullName:"Mihai Mares"}],equalEditorOne:{id:"190224",title:"Dr.",name:"Swee Hua Erin",middleName:null,surname:"Lim",slug:"swee-hua-erin-lim",fullName:"Swee Hua Erin Lim",profilePictureURL:"https://mts.intechopen.com/storage/users/190224/images/system/190224.png",biography:"Dr. Erin Lim is presently working as an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates and is affiliated as an Associate Professor to Perdana University-Royal College of Surgeons in Ireland, Selangor, Malaysia. She obtained her Ph.D. from Universiti Putra Malaysia in 2010 with a National Science Fellowship awarded from the Ministry of Science, Technology and Innovation Malaysia and has been actively involved in research ever since. Her main research interests include analysis of carriage and transmission of multidrug resistant bacteria in non-conventional settings, besides an interest in natural products for antimicrobial testing. She is heavily involved in the elucidation of mechanisms of reversal of resistance in bacteria in addition to investigating the immunological analyses of diseases, development of vaccination and treatment models in animals. She hopes her work will support the discovery of therapeutics in the clinical setting and assist in the combat against the burden of antibiotic resistance.",institutionString:"Abu Dhabi Women’s College",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Perdana University",institutionURL:null,country:{name:"Malaysia"}}},equalEditorTwo:{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai",profilePictureURL:"https://mts.intechopen.com/storage/users/221544/images/system/221544.jpeg",biography:"Dr. Lai Kok Song is an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates. He obtained his Ph.D. in Biological Sciences from Nara Institute of Science and Technology, Japan in 2012. Prior to his academic appointment, Dr. Lai worked as a Senior Scientist at the Ministry of Science, Technology and Innovation, Malaysia. His current research areas include antimicrobial resistance and plant-pathogen interaction. His particular interest lies in the study of the antimicrobial mechanism via membrane disruption of essential oils against multi-drug resistance bacteria through various biochemical, molecular and proteomic approaches. Ultimately, he hopes to uncover and determine novel biomarkers related to antibiotic resistance that can be developed into new therapeutic strategies.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Higher Colleges of Technology",institutionURL:null,country:{name:"United Arab Emirates"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10020",title:"Operations Management",subtitle:"Emerging Trend in the Digital Era",isOpenForSubmission:!1,hash:"526f0dbdc7e4d85b82ce8383ab894b4c",slug:"operations-management-emerging-trend-in-the-digital-era",bookSignature:"Antonella Petrillo, Fabio De Felice, Germano Lambert-Torres and Erik Bonaldi",coverURL:"https://cdn.intechopen.com/books/images_new/10020.jpg",editors:[{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9560",title:"Creativity",subtitle:"A Force to Innovation",isOpenForSubmission:!1,hash:"58f740bc17807d5d88d647c525857b11",slug:"creativity-a-force-to-innovation",bookSignature:"Pooja Jain",coverURL:"https://cdn.intechopen.com/books/images_new/9560.jpg",editors:[{id:"316765",title:"Dr.",name:"Pooja",middleName:null,surname:"Jain",slug:"pooja-jain",fullName:"Pooja Jain"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10192",title:"Background and Management of Muscular Atrophy",subtitle:null,isOpenForSubmission:!1,hash:"eca24028d89912b5efea56e179dff089",slug:"background-and-management-of-muscular-atrophy",bookSignature:"Julianna Cseri",coverURL:"https://cdn.intechopen.com/books/images_new/10192.jpg",editors:[{id:"135579",title:"Dr.",name:"Julianna",middleName:null,surname:"Cseri",slug:"julianna-cseri",fullName:"Julianna Cseri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9243",title:"Coastal Environments",subtitle:null,isOpenForSubmission:!1,hash:"8e05e5f631e935eef366980f2e28295d",slug:"coastal-environments",bookSignature:"Yuanzhi Zhang and X. San Liang",coverURL:"https://cdn.intechopen.com/books/images_new/9243.jpg",editors:[{id:"77597",title:"Prof.",name:"Yuanzhi",middleName:null,surname:"Zhang",slug:"yuanzhi-zhang",fullName:"Yuanzhi Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9385",title:"Renewable Energy",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"a6b446d19166f17f313008e6c056f3d8",slug:"renewable-energy-technologies-and-applications",bookSignature:"Tolga Taner, Archana Tiwari and Taha Selim Ustun",coverURL:"https://cdn.intechopen.com/books/images_new/9385.jpg",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:{id:"186791",title:"Dr.",name:"Archana",middleName:null,surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari",profilePictureURL:"https://mts.intechopen.com/storage/users/186791/images/system/186791.jpg",biography:"Dr. Archana Tiwari is Associate Professor at Amity University, India. Her research interests include renewable sources of energy from microalgae and further utilizing the residual biomass for the generation of value-added products, bioremediation through microalgae and microbial consortium, antioxidative enzymes and stress, and nutraceuticals from microalgae. She has been working on algal biotechnology for the last two decades. She has published her research in many international journals and has authored many books and chapters with renowned publishing houses. She has also delivered talks as an invited speaker at many national and international conferences. Dr. Tiwari is the recipient of several awards including Researcher of the Year and Distinguished Scientist.",institutionString:"Amity University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},equalEditorTwo:{id:"197609",title:"Prof.",name:"Taha Selim",middleName:null,surname:"Ustun",slug:"taha-selim-ustun",fullName:"Taha Selim Ustun",profilePictureURL:"https://mts.intechopen.com/storage/users/197609/images/system/197609.jpeg",biography:"Dr. Taha Selim Ustun received a Ph.D. in Electrical Engineering from Victoria University, Melbourne, Australia. He is a researcher with the Fukushima Renewable Energy Institute, AIST (FREA), where he leads the Smart Grid Cybersecurity Laboratory. Prior to that, he was a faculty member with the School of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. His current research interests include power systems protection, communication in power networks, distributed generation, microgrids, electric vehicle integration, and cybersecurity in smart grids. He serves on the editorial boards of IEEE Access, IEEE Transactions on Industrial Informatics, Energies, Electronics, Electricity, World Electric Vehicle and Information journals. Dr. Ustun is a member of the IEEE 2004 and 2800, IEC Renewable Energy Management WG 8, and IEC TC 57 WG17. He has been invited to run specialist courses in Africa, India, and China. He has delivered talks for the Qatar Foundation, the World Energy Council, the Waterloo Global Science Initiative, and the European Union Energy Initiative (EUEI). His research has attracted funding from prestigious programs in Japan, Australia, the European Union, and North America.",institutionString:"Fukushima Renewable Energy Institute, AIST (FREA)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Institute of Advanced Industrial Science and Technology",institutionURL:null,country:{name:"Japan"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8985",title:"Natural Resources Management and Biological Sciences",subtitle:null,isOpenForSubmission:!1,hash:"5c2e219a6c021a40b5a20c041dea88c4",slug:"natural-resources-management-and-biological-sciences",bookSignature:"Edward R. Rhodes and Humood Naser",coverURL:"https://cdn.intechopen.com/books/images_new/8985.jpg",editors:[{id:"280886",title:"Prof.",name:"Edward R",middleName:null,surname:"Rhodes",slug:"edward-r-rhodes",fullName:"Edward R Rhodes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10065",title:"Wavelet Theory",subtitle:null,isOpenForSubmission:!1,hash:"d8868e332169597ba2182d9b004d60de",slug:"wavelet-theory",bookSignature:"Somayeh Mohammady",coverURL:"https://cdn.intechopen.com/books/images_new/10065.jpg",editors:[{id:"109280",title:"Dr.",name:"Somayeh",middleName:null,surname:"Mohammady",slug:"somayeh-mohammady",fullName:"Somayeh Mohammady"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9644",title:"Glaciers and the Polar Environment",subtitle:null,isOpenForSubmission:!1,hash:"e8cfdc161794e3753ced54e6ff30873b",slug:"glaciers-and-the-polar-environment",bookSignature:"Masaki Kanao, Danilo Godone and Niccolò Dematteis",coverURL:"https://cdn.intechopen.com/books/images_new/9644.jpg",editors:[{id:"51959",title:"Dr.",name:"Masaki",middleName:null,surname:"Kanao",slug:"masaki-kanao",fullName:"Masaki Kanao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9550",title:"Entrepreneurship",subtitle:"Contemporary Issues",isOpenForSubmission:!1,hash:"9b4ac1ee5b743abf6f88495452b1e5e7",slug:"entrepreneurship-contemporary-issues",bookSignature:"Mladen Turuk",coverURL:"https://cdn.intechopen.com/books/images_new/9550.jpg",editors:[{id:"319755",title:"Prof.",name:"Mladen",middleName:null,surname:"Turuk",slug:"mladen-turuk",fullName:"Mladen Turuk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"9243",title:"Coastal Environments",subtitle:null,isOpenForSubmission:!1,hash:"8e05e5f631e935eef366980f2e28295d",slug:"coastal-environments",bookSignature:"Yuanzhi Zhang and X. San Liang",coverURL:"https://cdn.intechopen.com/books/images_new/9243.jpg",editedByType:"Edited by",editors:[{id:"77597",title:"Prof.",name:"Yuanzhi",middleName:null,surname:"Zhang",slug:"yuanzhi-zhang",fullName:"Yuanzhi Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10020",title:"Operations Management",subtitle:"Emerging Trend in the Digital Era",isOpenForSubmission:!1,hash:"526f0dbdc7e4d85b82ce8383ab894b4c",slug:"operations-management-emerging-trend-in-the-digital-era",bookSignature:"Antonella Petrillo, Fabio De Felice, Germano Lambert-Torres and Erik Bonaldi",coverURL:"https://cdn.intechopen.com/books/images_new/10020.jpg",editedByType:"Edited by",editors:[{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9521",title:"Antimicrobial Resistance",subtitle:"A One Health Perspective",isOpenForSubmission:!1,hash:"30949e78832e1afba5606634b52056ab",slug:"antimicrobial-resistance-a-one-health-perspective",bookSignature:"Mihai Mareș, Swee Hua Erin Lim, Kok-Song Lai and Romeo-Teodor Cristina",coverURL:"https://cdn.intechopen.com/books/images_new/9521.jpg",editedByType:"Edited by",editors:[{id:"88785",title:"Prof.",name:"Mihai",middleName:null,surname:"Mares",slug:"mihai-mares",fullName:"Mihai Mares"}],equalEditorOne:{id:"190224",title:"Dr.",name:"Swee Hua Erin",middleName:null,surname:"Lim",slug:"swee-hua-erin-lim",fullName:"Swee Hua Erin Lim",profilePictureURL:"https://mts.intechopen.com/storage/users/190224/images/system/190224.png",biography:"Dr. Erin Lim is presently working as an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates and is affiliated as an Associate Professor to Perdana University-Royal College of Surgeons in Ireland, Selangor, Malaysia. She obtained her Ph.D. from Universiti Putra Malaysia in 2010 with a National Science Fellowship awarded from the Ministry of Science, Technology and Innovation Malaysia and has been actively involved in research ever since. Her main research interests include analysis of carriage and transmission of multidrug resistant bacteria in non-conventional settings, besides an interest in natural products for antimicrobial testing. She is heavily involved in the elucidation of mechanisms of reversal of resistance in bacteria in addition to investigating the immunological analyses of diseases, development of vaccination and treatment models in animals. She hopes her work will support the discovery of therapeutics in the clinical setting and assist in the combat against the burden of antibiotic resistance.",institutionString:"Abu Dhabi Women’s College",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Perdana University",institutionURL:null,country:{name:"Malaysia"}}},equalEditorTwo:{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai",profilePictureURL:"https://mts.intechopen.com/storage/users/221544/images/system/221544.jpeg",biography:"Dr. Lai Kok Song is an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates. He obtained his Ph.D. in Biological Sciences from Nara Institute of Science and Technology, Japan in 2012. Prior to his academic appointment, Dr. Lai worked as a Senior Scientist at the Ministry of Science, Technology and Innovation, Malaysia. His current research areas include antimicrobial resistance and plant-pathogen interaction. His particular interest lies in the study of the antimicrobial mechanism via membrane disruption of essential oils against multi-drug resistance bacteria through various biochemical, molecular and proteomic approaches. Ultimately, he hopes to uncover and determine novel biomarkers related to antibiotic resistance that can be developed into new therapeutic strategies.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Higher Colleges of Technology",institutionURL:null,country:{name:"United Arab Emirates"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9560",title:"Creativity",subtitle:"A Force to Innovation",isOpenForSubmission:!1,hash:"58f740bc17807d5d88d647c525857b11",slug:"creativity-a-force-to-innovation",bookSignature:"Pooja Jain",coverURL:"https://cdn.intechopen.com/books/images_new/9560.jpg",editedByType:"Edited by",editors:[{id:"316765",title:"Dr.",name:"Pooja",middleName:null,surname:"Jain",slug:"pooja-jain",fullName:"Pooja Jain"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9669",title:"Recent Advances in Rice Research",subtitle:null,isOpenForSubmission:!1,hash:"12b06cc73e89af1e104399321cc16a75",slug:"recent-advances-in-rice-research",bookSignature:"Mahmood-ur- Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9669.jpg",editedByType:"Edited by",editors:[{id:"185476",title:"Dr.",name:"Mahmood-Ur-",middleName:null,surname:"Rahman Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-Ur- Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10192",title:"Background and Management of Muscular Atrophy",subtitle:null,isOpenForSubmission:!1,hash:"eca24028d89912b5efea56e179dff089",slug:"background-and-management-of-muscular-atrophy",bookSignature:"Julianna Cseri",coverURL:"https://cdn.intechopen.com/books/images_new/10192.jpg",editedByType:"Edited by",editors:[{id:"135579",title:"Dr.",name:"Julianna",middleName:null,surname:"Cseri",slug:"julianna-cseri",fullName:"Julianna Cseri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9550",title:"Entrepreneurship",subtitle:"Contemporary Issues",isOpenForSubmission:!1,hash:"9b4ac1ee5b743abf6f88495452b1e5e7",slug:"entrepreneurship-contemporary-issues",bookSignature:"Mladen Turuk",coverURL:"https://cdn.intechopen.com/books/images_new/9550.jpg",editedByType:"Edited by",editors:[{id:"319755",title:"Prof.",name:"Mladen",middleName:null,surname:"Turuk",slug:"mladen-turuk",fullName:"Mladen Turuk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10065",title:"Wavelet Theory",subtitle:null,isOpenForSubmission:!1,hash:"d8868e332169597ba2182d9b004d60de",slug:"wavelet-theory",bookSignature:"Somayeh Mohammady",coverURL:"https://cdn.intechopen.com/books/images_new/10065.jpg",editedByType:"Edited by",editors:[{id:"109280",title:"Dr.",name:"Somayeh",middleName:null,surname:"Mohammady",slug:"somayeh-mohammady",fullName:"Somayeh Mohammady"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9313",title:"Clay Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"6fa7e70396ff10620e032bb6cfa6fb72",slug:"clay-science-and-technology",bookSignature:"Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/9313.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",middleName:null,surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9888",title:"Nuclear Power Plants",subtitle:"The Processes from the Cradle to the Grave",isOpenForSubmission:!1,hash:"c2c8773e586f62155ab8221ebb72a849",slug:"nuclear-power-plants-the-processes-from-the-cradle-to-the-grave",bookSignature:"Nasser Awwad",coverURL:"https://cdn.intechopen.com/books/images_new/9888.jpg",editedByType:"Edited by",editors:[{id:"145209",title:"Prof.",name:"Nasser",middleName:"S",surname:"Awwad",slug:"nasser-awwad",fullName:"Nasser Awwad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"403",title:"Microbial Genetics",slug:"karyology-microbial-genetics",parent:{title:"Karyology",slug:"karyology"},numberOfBooks:5,numberOfAuthorsAndEditors:169,numberOfWosCitations:69,numberOfCrossrefCitations:34,numberOfDimensionsCitations:80,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicSlug:"karyology-microbial-genetics",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"5085",title:"Telomere",subtitle:"A Complex End of a Chromosome",isOpenForSubmission:!1,hash:"2a8f40859d7bc312dea327fd9b058a20",slug:"telomere-a-complex-end-of-a-chromosome",bookSignature:"Marcelo L. Larramendy",coverURL:"https://cdn.intechopen.com/books/images_new/5085.jpg",editedByType:"Edited by",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4720",title:"Flow Cytometry",subtitle:"Select Topics",isOpenForSubmission:!1,hash:"5a842a00d86bc7f956a5fd1fe6d62b8a",slug:"flow-cytometry-select-topics",bookSignature:"Ingrid Schmid",coverURL:"https://cdn.intechopen.com/books/images_new/4720.jpg",editedByType:"Edited by",editors:[{id:"109787",title:"M.Sc.",name:"Ingrid",middleName:null,surname:"Schmid",slug:"ingrid-schmid",fullName:"Ingrid Schmid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3536",title:"Chromatin Remodelling",subtitle:null,isOpenForSubmission:!1,hash:"31abe97fe35989e4547bab854b38e03a",slug:"chromatin-remodelling",bookSignature:"Danuta Radzioch",coverURL:"https://cdn.intechopen.com/books/images_new/3536.jpg",editedByType:"Edited by",editors:[{id:"165250",title:"Dr.",name:"Danuta",middleName:null,surname:"Radzioch",slug:"danuta-radzioch",fullName:"Danuta Radzioch"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1578",title:"Flow Cytometry",subtitle:"Recent Perspectives",isOpenForSubmission:!1,hash:"fccad401cbcf998ea4de62d524abf82d",slug:"flow-cytometry-recent-perspectives",bookSignature:"Ingrid Schmid",coverURL:"https://cdn.intechopen.com/books/images_new/1578.jpg",editedByType:"Edited by",editors:[{id:"109787",title:"M.Sc.",name:"Ingrid",middleName:null,surname:"Schmid",slug:"ingrid-schmid",fullName:"Ingrid Schmid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2291",title:"Clinical Flow Cytometry",subtitle:"Emerging Applications",isOpenForSubmission:!1,hash:"a5414617aafe62d7c6ec8205028f6967",slug:"clinical-flow-cytometry-emerging-applications",bookSignature:"Ingrid Schmid",coverURL:"https://cdn.intechopen.com/books/images_new/2291.jpg",editedByType:"Edited by",editors:[{id:"109787",title:"M.Sc.",name:"Ingrid",middleName:null,surname:"Schmid",slug:"ingrid-schmid",fullName:"Ingrid Schmid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:5,mostCitedChapters:[{id:"44225",doi:"10.5772/55370",title:"Role of Enhancer of Zeste Homolog 2 Polycomb Protein and Its Significance in Tumor Progression and Cell Differentiation",slug:"role-of-enhancer-of-zeste-homolog-2-polycomb-protein-and-its-significance-in-tumor-progression-and-c",totalDownloads:3389,totalCrossrefCites:4,totalDimensionsCites:7,book:{slug:"chromatin-remodelling",title:"Chromatin Remodelling",fullTitle:"Chromatin Remodelling"},signatures:"Irene Marchesi and Luigi Bagella",authors:[{id:"91878",title:"Prof.",name:"Luigi",middleName:null,surname:"Bagella",slug:"luigi-bagella",fullName:"Luigi Bagella"},{id:"164852",title:"Dr.",name:"Irene",middleName:null,surname:"Marchesi",slug:"irene-marchesi",fullName:"Irene Marchesi"}]},{id:"52461",doi:"10.5772/65353",title:"Molecular Diagnosis and Precision Therapeutic Approaches for Telomere Biology Disorders",slug:"molecular-diagnosis-and-precision-therapeutic-approaches-for-telomere-biology-disorders",totalDownloads:1213,totalCrossrefCites:2,totalDimensionsCites:6,book:{slug:"telomere-a-complex-end-of-a-chromosome",title:"Telomere",fullTitle:"Telomere - A Complex End of a Chromosome"},signatures:"Rosario Perona, Laura Iarriccio, Laura Pintado-Berninches, Javier\nRodriguez-Centeno, Cristina Manguan-Garcia, Elena Garcia, Blanca\nLopez-Ayllón and Leandro Sastre",authors:[{id:"179373",title:"Dr.",name:"Leandro",middleName:null,surname:"Sastre",slug:"leandro-sastre",fullName:"Leandro Sastre"},{id:"184869",title:"Dr.",name:"Rosario",middleName:null,surname:"Perona",slug:"rosario-perona",fullName:"Rosario Perona"},{id:"184870",title:"Dr.",name:"Laura",middleName:null,surname:"Iarriccio",slug:"laura-iarriccio",fullName:"Laura Iarriccio"},{id:"184871",title:"MSc.",name:"Laura",middleName:null,surname:"Pintado-Berninches",slug:"laura-pintado-berninches",fullName:"Laura Pintado-Berninches"},{id:"184872",title:"MSc.",name:"Javier",middleName:null,surname:"Rodriguez-Centeno",slug:"javier-rodriguez-centeno",fullName:"Javier Rodriguez-Centeno"},{id:"184873",title:"Ms.",name:"Cristina",middleName:null,surname:"Manguan-Garcia",slug:"cristina-manguan-garcia",fullName:"Cristina Manguan-Garcia"},{id:"184874",title:"Dr.",name:"Elena",middleName:null,surname:"Garcia",slug:"elena-garcia",fullName:"Elena Garcia"},{id:"184875",title:"Dr.",name:"Blanca",middleName:null,surname:"Lopez-Ayllon",slug:"blanca-lopez-ayllon",fullName:"Blanca Lopez-Ayllon"}]},{id:"37421",doi:"10.5772/38616",title:"What Flow Cytometry can Tell Us About Marine Micro-Organisms – Current Status and Future Applications",slug:"what-flow-cytometry-can-tell-about-marine-microrganisms-current-status-and-future-applications",totalDownloads:2396,totalCrossrefCites:2,totalDimensionsCites:4,book:{slug:"flow-cytometry-recent-perspectives",title:"Flow Cytometry",fullTitle:"Flow Cytometry - Recent Perspectives"},signatures:"A. Manti, S. Papa and P. Boi",authors:[{id:"118302",title:"Dr.",name:"Anita",middleName:null,surname:"Manti",slug:"anita-manti",fullName:"Anita Manti"}]}],mostDownloadedChaptersLast30Days:[{id:"49878",title:"Immunophenotyping of Acute Leukemias – From Biology to Clinical Application",slug:"immunophenotyping-of-acute-leukemias-from-biology-to-clinical-application",totalDownloads:2485,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"flow-cytometry-select-topics",title:"Flow Cytometry",fullTitle:"Flow Cytometry - Select Topics"},signatures:"Francesco Mannelli",authors:[{id:"178848",title:"M.D.",name:"Francesco",middleName:null,surname:"Mannelli",slug:"francesco-mannelli",fullName:"Francesco Mannelli"}]},{id:"50878",title:"Detection of Anti-HLA Antibodies by Flow Cytometer",slug:"detection-of-anti-hla-antibodies-by-flow-cytometer",totalDownloads:2351,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"flow-cytometry-select-topics",title:"Flow Cytometry",fullTitle:"Flow Cytometry - Select Topics"},signatures:"Tülay Kılıçaslan Ayna and Aslı Özkızılcık Koçyiğit",authors:[{id:"178265",title:"Dr.",name:"Tulay",middleName:null,surname:"Kilicaslan Ayna",slug:"tulay-kilicaslan-ayna",fullName:"Tulay Kilicaslan Ayna"}]},{id:"37054",title:"Effect of Monocyte Locomotion Inhibitory Factor (MLIF) on the Activation and Production of Intracellular Cytokine and Chemokine Receptors in Human T CD4+ Lymphocytes Measured by Flow Cytometry",slug:"effect-of-monocyte-inhibitory-locomotion-factor-mlif-on-the-activation-and-production-of-intracellul",totalDownloads:1566,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"clinical-flow-cytometry-emerging-applications",title:"Clinical Flow Cytometry",fullTitle:"Clinical Flow Cytometry - Emerging Applications"},signatures:"Sara Rojas-Dotor",authors:[{id:"109461",title:"Dr.",name:"Sara",middleName:null,surname:"Rojas-Dotor",slug:"sara-rojas-dotor",fullName:"Sara Rojas-Dotor"}]},{id:"50807",title:"The Role of Cytometry for Male Fertility Assessment in Toxicology",slug:"the-role-of-cytometry-for-male-fertility-assessment-in-toxicology",totalDownloads:1268,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"flow-cytometry-select-topics",title:"Flow Cytometry",fullTitle:"Flow Cytometry - Select Topics"},signatures:"Maria de Lourdes Pereira, Helena Oliveira, Henrique M.A.C.\nFonseca, Fernando Garcia e Costa and Conceição Santos",authors:[{id:"79715",title:"Prof.",name:"Maria De Lourdes",middleName:null,surname:"Pereira",slug:"maria-de-lourdes-pereira",fullName:"Maria De Lourdes Pereira"},{id:"174419",title:"Prof.",name:"Fernando",middleName:null,surname:"Garcia E Costa",slug:"fernando-garcia-e-costa",fullName:"Fernando Garcia E Costa"},{id:"185982",title:"Prof.",name:"Helena",middleName:null,surname:"Oliveira",slug:"helena-oliveira",fullName:"Helena Oliveira"},{id:"185983",title:"Prof.",name:"Henrique M.A.C.",middleName:null,surname:"Fonseca",slug:"henrique-m.a.c.-fonseca",fullName:"Henrique M.A.C. Fonseca"},{id:"185984",title:"Prof.",name:"Conceição",middleName:null,surname:"Santos",slug:"conceicao-santos",fullName:"Conceição Santos"}]},{id:"37421",title:"What Flow Cytometry can Tell Us About Marine Micro-Organisms – Current Status and Future Applications",slug:"what-flow-cytometry-can-tell-about-marine-microrganisms-current-status-and-future-applications",totalDownloads:2393,totalCrossrefCites:2,totalDimensionsCites:4,book:{slug:"flow-cytometry-recent-perspectives",title:"Flow Cytometry",fullTitle:"Flow Cytometry - Recent Perspectives"},signatures:"A. Manti, S. Papa and P. Boi",authors:[{id:"118302",title:"Dr.",name:"Anita",middleName:null,surname:"Manti",slug:"anita-manti",fullName:"Anita Manti"}]},{id:"37445",title:"Retracted: Applications of Quantum Dots in Flow Cytometry",slug:"applications-of-quantum-dots-in-flow-cytometry",totalDownloads:1852,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"flow-cytometry-recent-perspectives",title:"Flow Cytometry",fullTitle:"Flow Cytometry - Recent Perspectives"},signatures:"Dimitrios Kirmizis, Fani Chatzopoulou, Eleni Gavriilaki and Dimitrios Chatzidimitriou",authors:[{id:"45414",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Kirmizis",slug:"dimitrios-kirmizis",fullName:"Dimitrios Kirmizis"},{id:"122229",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Chatzidimitriou",slug:"dimitrios-chatzidimitriou",fullName:"Dimitrios Chatzidimitriou"},{id:"134576",title:"BSc.",name:"Fani",middleName:null,surname:"Chatzopoulou",slug:"fani-chatzopoulou",fullName:"Fani Chatzopoulou"},{id:"134577",title:"Dr.",name:"Helen",middleName:null,surname:"Gavriilaki",slug:"helen-gavriilaki",fullName:"Helen Gavriilaki"}]},{id:"51979",title:"Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases",slug:"telomeres-and-cellular-senescence-in-metabolic-and-endocrine-diseases",totalDownloads:1188,totalCrossrefCites:0,totalDimensionsCites:1,book:{slug:"telomere-a-complex-end-of-a-chromosome",title:"Telomere",fullTitle:"Telomere - A Complex End of a Chromosome"},signatures:"Ryusaku Matsumoto and Yutaka Takahashi",authors:[{id:"187040",title:"Dr.",name:"Yutaka",middleName:null,surname:"Takahashi",slug:"yutaka-takahashi",fullName:"Yutaka Takahashi"}]},{id:"52461",title:"Molecular Diagnosis and Precision Therapeutic Approaches for Telomere Biology Disorders",slug:"molecular-diagnosis-and-precision-therapeutic-approaches-for-telomere-biology-disorders",totalDownloads:1213,totalCrossrefCites:2,totalDimensionsCites:6,book:{slug:"telomere-a-complex-end-of-a-chromosome",title:"Telomere",fullTitle:"Telomere - A Complex End of a Chromosome"},signatures:"Rosario Perona, Laura Iarriccio, Laura Pintado-Berninches, Javier\nRodriguez-Centeno, Cristina Manguan-Garcia, Elena Garcia, Blanca\nLopez-Ayllón and Leandro Sastre",authors:[{id:"179373",title:"Dr.",name:"Leandro",middleName:null,surname:"Sastre",slug:"leandro-sastre",fullName:"Leandro Sastre"},{id:"184869",title:"Dr.",name:"Rosario",middleName:null,surname:"Perona",slug:"rosario-perona",fullName:"Rosario Perona"},{id:"184870",title:"Dr.",name:"Laura",middleName:null,surname:"Iarriccio",slug:"laura-iarriccio",fullName:"Laura Iarriccio"},{id:"184871",title:"MSc.",name:"Laura",middleName:null,surname:"Pintado-Berninches",slug:"laura-pintado-berninches",fullName:"Laura Pintado-Berninches"},{id:"184872",title:"MSc.",name:"Javier",middleName:null,surname:"Rodriguez-Centeno",slug:"javier-rodriguez-centeno",fullName:"Javier Rodriguez-Centeno"},{id:"184873",title:"Ms.",name:"Cristina",middleName:null,surname:"Manguan-Garcia",slug:"cristina-manguan-garcia",fullName:"Cristina Manguan-Garcia"},{id:"184874",title:"Dr.",name:"Elena",middleName:null,surname:"Garcia",slug:"elena-garcia",fullName:"Elena Garcia"},{id:"184875",title:"Dr.",name:"Blanca",middleName:null,surname:"Lopez-Ayllon",slug:"blanca-lopez-ayllon",fullName:"Blanca Lopez-Ayllon"}]},{id:"44220",title:"Condensins, Chromatin Remodeling and Gene Transcription",slug:"condensins-chromatin-remodeling-and-gene-transcription",totalDownloads:2090,totalCrossrefCites:0,totalDimensionsCites:1,book:{slug:"chromatin-remodelling",title:"Chromatin Remodelling",fullTitle:"Chromatin Remodelling"},signatures:"Laurence O. W. Wilson and Aude M. Fahrer",authors:[{id:"164464",title:"Mr.",name:"Laurence",middleName:null,surname:"Wilson",slug:"laurence-wilson",fullName:"Laurence Wilson"},{id:"164788",title:"Dr.",name:"Aude",middleName:null,surname:"Fahrer",slug:"aude-fahrer",fullName:"Aude Fahrer"}]},{id:"44225",title:"Role of Enhancer of Zeste Homolog 2 Polycomb Protein and Its Significance in Tumor Progression and Cell Differentiation",slug:"role-of-enhancer-of-zeste-homolog-2-polycomb-protein-and-its-significance-in-tumor-progression-and-c",totalDownloads:3388,totalCrossrefCites:4,totalDimensionsCites:7,book:{slug:"chromatin-remodelling",title:"Chromatin Remodelling",fullTitle:"Chromatin Remodelling"},signatures:"Irene Marchesi and Luigi Bagella",authors:[{id:"91878",title:"Prof.",name:"Luigi",middleName:null,surname:"Bagella",slug:"luigi-bagella",fullName:"Luigi Bagella"},{id:"164852",title:"Dr.",name:"Irene",middleName:null,surname:"Marchesi",slug:"irene-marchesi",fullName:"Irene Marchesi"}]}],onlineFirstChaptersFilter:{topicSlug:"karyology-microbial-genetics",limit:3,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[{type:"book",id:"10176",title:"Microgrids and Local Energy Systems",subtitle:null,isOpenForSubmission:!0,hash:"c32b4a5351a88f263074b0d0ca813a9c",slug:null,bookSignature:"Prof. Nick Jenkins",coverURL:"https://cdn.intechopen.com/books/images_new/10176.jpg",editedByType:null,editors:[{id:"55219",title:"Prof.",name:"Nick",middleName:null,surname:"Jenkins",slug:"nick-jenkins",fullName:"Nick Jenkins"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:8,limit:8,total:1},route:{name:"profile.detail",path:"/profiles/186927/carlos-lazaro",hash:"",query:{},params:{id:"186927",slug:"carlos-lazaro"},fullPath:"/profiles/186927/carlos-lazaro",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()