Determinants of convection volume.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7806",leadTitle:null,fullTitle:"Public Sector Crisis Management",title:"Public Sector Crisis Management",subtitle:null,reviewType:"peer-reviewed",abstract:"The term “crisis management” was applied to business only after the publication of the monograph “Crisis Management: Planning for the Inevitable” by Steven Fink in 1986. Since then, this term has turned from a journalistic cliche into a scientific concept, and its concept, theory, and methodology have been further developed.It is the turning point in the meaning of the word “crisis” that indicates the possibility of changing the situation by making decisions that contribute to changing the vector of development of events from destruction to recovery and further development. From the above, the general definition of the term “crisis management” follows as a process of saving the system from its destructive effects. The activity of the crisis manager is always temporary and stops as a result of a favorable overcoming of the crisis or vice versa—the destruction of the system. Therefore, the criterion for the success of a manager in emergency crisis management is effectiveness as an absolute measure of the presence or absence of a result—it either exists or does not exist.",isbn:"978-1-83880-982-9",printIsbn:"978-1-83880-981-2",pdfIsbn:"978-1-83880-983-6",doi:"10.5772/intechopen.77623",price:119,priceEur:129,priceUsd:155,slug:"public-sector-crisis-management",numberOfPages:174,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"84a998820880e0f006a5e9eac40d83e7",bookSignature:"Alexander Rozanov, Alexander Barannikov, Olga Belyaeva and Mikhail Smirnov",publishedDate:"October 28th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7806.jpg",numberOfDownloads:6573,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:3,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:6,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 3rd 2019",dateEndSecondStepPublish:"December 25th 2019",dateEndThirdStepPublish:"February 23rd 2020",dateEndFourthStepPublish:"May 13th 2020",dateEndFifthStepPublish:"July 12th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"233092",title:"Dr.",name:"Alexander",middleName:null,surname:"Rozanov",slug:"alexander-rozanov",fullName:"Alexander Rozanov",profilePictureURL:"https://mts.intechopen.com/storage/users/233092/images/system/233092.jfif",biography:"Dr. Alexander S. Rozanov is a specialist in Global Security and a graduate of Lomonosov Moscow State University (Russia). He is the author of more than 60 scientific publications. After graduating, Dr. Rozanov worked in the Russian Ministry of Foreign Affairs and the Russian Government. In 2014 he received his Ph.D. in Politics from Lomonosov Moscow State University. From 2014 to 2017, Dr. Rozanov was invited as a guest lecturer in several well-known universities – University of California, Santa Barbara (USA), Paris-Sorbonne (France), and Wroclaw University (Poland). Dr. Rozanov specializes in the analysis of global and regional conflicts, as well as the global dynamics of world development. He is a member of the European International Studies Association (Great Britain). Dr. Rozanov is an Associate Professor at the Faculty of Regional Studies and International Cooperation at the Russian Academy of National Economy and Public Administration.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Russian Presidential Academy of National Economy and Public Administration",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"303094",title:"Dr.",name:"Alexander",middleName:null,surname:"Barannikov",slug:"alexander-barannikov",fullName:"Alexander Barannikov",profilePictureURL:"https://mts.intechopen.com/storage/users/303094/images/system/303094.jfif",biography:"Dr. Barannikov has a PhD in Economics and Management. From 2012 to 2014, he was an independent expert of the Commission of the Federal Agency for the supply of weapons, military, special equipment and materiel on compliance with the requirements for official behavior of Federal civil servants of the Central Office of the Federal Agency. His list of scientific works includes more than 87 scientific works, including 39 inventions. Dr. Barannikov is a Professor at the Russian Academy of National Economy and Public Administration.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"303097",title:"Dr.",name:"Olga",middleName:null,surname:"Belyaeva",slug:"olga-belyaeva",fullName:"Olga Belyaeva",profilePictureURL:"https://mts.intechopen.com/storage/users/303097/images/system/303097.jfif",biography:"Dr. Olga Belyaeva is an Associate Professor at the Russian Academy of National Economy and Public Administration at the Department of Regional Management of the Faculty of International Regional Studies and Regional Management. She has a PhD in Regional Economy. Dr. Belyaeva has 2 specialties – a professional lawyer and an economist. Dr. Belyaeva has published more than 80 scientific publications. She has been providing lectures since 2006. From 2003 to 2006 she worked in the field of audits of small and medium-sized businesses.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:{id:"308591",title:"Dr.",name:"Mikhail",middleName:null,surname:"Smirnov",slug:"mikhail-smirnov",fullName:"Mikhail Smirnov",profilePictureURL:"https://mts.intechopen.com/storage/users/308591/images/system/308591.jfif",biography:"Michael Smirnov is a Professor at the Russian Academy of National Economy and Public Administration. He has a PhD in Law. For more than 15 years, Dr. Smirnov worked as a practical lawyer in international banks and consulting companies, at the same time providing lectures at Lomonosov MSU and Russian Academy of National Economy and Public Administration. He is the author of more than 60 scientific publications. Dr. Smirnov is currently the head of the Academic Program ‘Legal Support of Financial Technologies’.",institutionString:"Russian Academy of National Economy and Public Administration",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorFour:null,coeditorFive:null,topics:[{id:"272",title:"Management",slug:"management"}],chapters:[{id:"72017",title:"Crisis Management and Communication Strategies: RUSAL’s Case",doi:"10.5772/intechopen.91644",slug:"crisis-management-and-communication-strategies-rusal-s-case",totalDownloads:651,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"No company is immune to crisis situations, an affirmation which, despite its triviality, is undeniably true. However, from the early 2014, such statement may have become even more true to Russian corporations, as the annexation of the Crimean Peninsula gave start to rounds of economic sanctions that are still perpetrated today. Such measures, which were initiated in response to the Kremlin’s political maneuvers, have hit a number of Russian companies, and increased the degree of uncertainty in which they have to operate, as they see economic restriction’s impact not only on the business activity tangible factors—i.e., economic rewards, service, and performance—but also on intangible factors—i.e., image and reputation—as well. Crises are integral parts of all world systems, unfortunately. While they are a theoretically well-understood issue, in practice, crises are perceived as a very painful phenomenon. A crisis can be compared to riding a roller coaster. First, as we gain speed and climb up the tracks we are filled with a sense of joy and delight. These feelings are quickly replaced with anticipation, panic, and fear as the roller coaster plunges into the “abyss.”",signatures:"Alexander Rozanov, Maria Ivanchenko, Alexandra Baranova, Mikhail Smirnov, Olga Belyaeva, Alexander Barannikov, Mikhail Ilichev, Ludmila Ilicheva, Biyaslan Tambiev, Maria Krotovskaya, Vladimir Chilingaryan, Tatiana Grabovich, Zaru Dulatkyzy, Alla Nikolaeva, Svetlana Ivanova, Kwame Boateng, Mattia Masolletti, Marina Danilina, Dmitry Medvedev and Natalya Ogneva",downloadPdfUrl:"/chapter/pdf-download/72017",previewPdfUrl:"/chapter/pdf-preview/72017",authors:[{id:"233092",title:"Dr.",name:"Alexander",surname:"Rozanov",slug:"alexander-rozanov",fullName:"Alexander Rozanov"},{id:"303094",title:"Dr.",name:"Alexander",surname:"Barannikov",slug:"alexander-barannikov",fullName:"Alexander Barannikov"},{id:"312160",title:null,name:"Olga",surname:"Belyaeva",slug:"olga-belyaeva",fullName:"Olga Belyaeva"},{id:"312161",title:null,name:"Mikhail",surname:"Smirnov",slug:"mikhail-smirnov",fullName:"Mikhail Smirnov"},{id:"312162",title:null,name:"Alexandra",surname:"Baranova",slug:"alexandra-baranova",fullName:"Alexandra Baranova"},{id:"312163",title:null,name:"Natalya",surname:"Ogneva",slug:"natalya-ogneva",fullName:"Natalya Ogneva"},{id:"312164",title:null,name:"Dmitry",surname:"Medvedev",slug:"dmitry-medvedev",fullName:"Dmitry Medvedev"},{id:"312165",title:null,name:"Marina",surname:"Danilina",slug:"marina-danilina",fullName:"Marina Danilina"},{id:"312197",title:"Ms.",name:"Maria",surname:"Ivanchenko",slug:"maria-ivanchenko",fullName:"Maria Ivanchenko"},{id:"316770",title:"Dr.",name:"Mattia",surname:"Masolletti",slug:"mattia-masolletti",fullName:"Mattia Masolletti"},{id:"316771",title:"Dr.",name:"Kwame",surname:"Boateng",slug:"kwame-boateng",fullName:"Kwame Boateng"},{id:"317588",title:"Dr.",name:"Svetlana",surname:"Ivanova",slug:"svetlana-ivanova",fullName:"Svetlana Ivanova"},{id:"317589",title:"Dr.",name:"Alla A.",surname:"Nikolaeva",slug:"alla-a.-nikolaeva",fullName:"Alla A. Nikolaeva"},{id:"317590",title:"Dr.",name:"Zaru",surname:"Dulatkyzy",slug:"zaru-dulatkyzy",fullName:"Zaru Dulatkyzy"},{id:"317773",title:null,name:"Tatiana",surname:"Grabovich",slug:"tatiana-grabovich",fullName:"Tatiana Grabovich"},{id:"317774",title:null,name:"Vladimir",surname:"Chilingaryan",slug:"vladimir-chilingaryan",fullName:"Vladimir Chilingaryan"},{id:"318393",title:null,name:"Maria",surname:"Krotovskaya",slug:"maria-krotovskaya",fullName:"Maria Krotovskaya"},{id:"318394",title:null,name:"Biyaslan",surname:"Tambiev",slug:"biyaslan-tambiev",fullName:"Biyaslan Tambiev"}],corrections:null},{id:"72314",title:"The Political Economy of Crisis Recovery",doi:"10.5772/intechopen.92586",slug:"the-political-economy-of-crisis-recovery",totalDownloads:601,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The aftermath of the global financial crisis marked another stress test for welfare states and varieties of capitalism. More than ever before, governments were forced to consider substantial reforms to welfare provision and enact flexibility-enhancing measures in order to improve financial solvency and economic performance. The crash, however, was not only a regionally uneven process in its origins but also led to makeshift or uneven policy responses. As a result, the socio-economic effects of the downturn and political reactions to it varied considerably among countries. Nevertheless, there have been some common trends in outcome measures. These have served to blur the dividing lines between different welfare states and production systems, so vividly captured in the mainstream political economy literature.",signatures:"Mohammad Ferdosi",downloadPdfUrl:"/chapter/pdf-download/72314",previewPdfUrl:"/chapter/pdf-preview/72314",authors:[{id:"316998",title:"Dr.",name:"Mohammad",surname:"Ferdosi",slug:"mohammad-ferdosi",fullName:"Mohammad Ferdosi"}],corrections:null},{id:"72395",title:"Contagion, Exchange Rate, and Financial Volatility: Indonesian Case in Global Financial Turbulence",doi:"10.5772/intechopen.92275",slug:"contagion-exchange-rate-and-financial-volatility-indonesian-case-in-global-financial-turbulence",totalDownloads:589,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Global turbulence after the financial crisis has hit Indonesia and almost all emerging countries. Quantitative Easing (QE) normalization (tapering of) has caused the capital outflows from emerging countries. Trade war and increasing geopolitical tension together raise the pressure. Argentina and Turkey have been experiencing economic shock. Indonesia should identify the contagion possibility and refer to Thai baht contagion experience in 1997. This paper assesses the contagion, exchange rate, and financial volatility triggered by global turbulence and Argentina-Turkey crisis in 2018. We use vector autoregression (VAR), simple correlation, dynamic conditional correlation (DCC), and regression method. We will investigate the potential contagion both in stock and exchange rate markets and in the rupiah exchange rate determination from both contagion and fundamental factors regarding the balance of payment (BOP) condition. The empirical result shows the potential contagion from Argentina and Turkey’s financial crisis to the Indonesian economy, especially to the stock market and exchange rate. The regression and correlation result also shows that Turkey has a higher financial contagion effect than Argentina to Indonesian financial market. Balance of payment condition also has the significant effect to explain rupiah exchange rate depreciation.",signatures:"Telisa Falianty and Arif Budimanta",downloadPdfUrl:"/chapter/pdf-download/72395",previewPdfUrl:"/chapter/pdf-preview/72395",authors:[{id:"317414",title:"Dr.",name:"Telisa",surname:"Falianty",slug:"telisa-falianty",fullName:"Telisa Falianty"},{id:"317419",title:"Dr.",name:"Arif",surname:"Budimanta",slug:"arif-budimanta",fullName:"Arif Budimanta"}],corrections:null},{id:"73192",title:"State Capitalism in Belarus: Behind Economic Anemia",doi:"10.5772/intechopen.93606",slug:"state-capitalism-in-belarus-behind-economic-anemia",totalDownloads:902,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"Belarus’ economic model looked rather successful in the late 1990s and in the 2000s with its economic growth above 7% per year. But during the last decade, Belarusian annual economic growth has fallen at the average level around 1% per year. This chapter reveals the rarely known case of state capitalism in this post-Soviet country with its specific indicators, and instruments behind economic anemia. It also outlines several traps on the way of Belarusian economic growth: “debt trap,” “middle-income trap,” “social burden trap,” “resource curse trap,” “conflict neighbors trap,” and “forceful pressure trap.” These pitfalls lead to the long-term economic slowdown in the Republic of Belarus. The consequences of such economic anemia bring to another discussion about the role of public values in support of state capitalism in Belarus.",signatures:"Kiryl Rudy",downloadPdfUrl:"/chapter/pdf-download/73192",previewPdfUrl:"/chapter/pdf-preview/73192",authors:[{id:"323827",title:"Prof.",name:"Kiryl",surname:"Rudy",slug:"kiryl-rudy",fullName:"Kiryl Rudy"}],corrections:null},{id:"70824",title:"Crisis Management and the Public Sector: Key Trends and Perspectives",doi:"10.5772/intechopen.90855",slug:"crisis-management-and-the-public-sector-key-trends-and-perspectives",totalDownloads:1040,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"A crisis is a situation approaching a dangerous phase, which requires urgent intervention to avoid harmful effects on the body of an organization in order to return to normal situation. It is a decisive and critical time for the organization, where the wrong decision can even cost its viability. This situation can shape political, legal, economic, and governmental impact on its activities. From different definitions of crisis, we seek to underscore key elements of a crisis that may threat a public organization and, also, to highlight both the elements of management responsiveness resulting in the loss of control in the organization, regarding the short time demand for decision-making. The key purpose of this chapter is to illustrate the basis available in the international literature, upon which public risk mechanisms can be reviewed and chosen in public sector organizations under the scope of their applicability.",signatures:"Christos Lemonakis and Antonios Zairis",downloadPdfUrl:"/chapter/pdf-download/70824",previewPdfUrl:"/chapter/pdf-preview/70824",authors:[{id:"311797",title:"Dr.",name:"Christos",surname:"Lemonakis",slug:"christos-lemonakis",fullName:"Christos Lemonakis"},{id:"313069",title:"Prof.",name:"Antonios",surname:"Zairis",slug:"antonios-zairis",fullName:"Antonios Zairis"}],corrections:null},{id:"72981",title:"Applying Monte Carlo Simulation in New Tech",doi:"10.5772/intechopen.91264",slug:"applying-monte-carlo-simulation-in-new-tech",totalDownloads:384,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Monte Carlo in Monaco is given to the theory for mathematics, whose simulation process involves generating chance variables and exhibiting random behaviours in nature. This simulation is a powerful statistical analysis tool and widely used in both non-engineering fields and engineering fields for new perspectives. This simulation has been applied to diverse problems ranging from the simulation of complex physical phenomena such as atom collisions, to the simulation of river boundary layers as meanders and Dow Jones forecasting. It can deal with many random variables, various distribution types and highly nonlinear engineering models, while Monte Carlo is also suitable for solving complex engineering problems in two areas which are varying randomly. Monte Carlo simulation is given as an application for hydrogen energy potential determination.",signatures:"Levent Yilmaz",downloadPdfUrl:"/chapter/pdf-download/72981",previewPdfUrl:"/chapter/pdf-preview/72981",authors:[{id:"305285",title:"Prof.",name:"Levent",surname:"Yilmaz",slug:"levent-yilmaz",fullName:"Levent Yilmaz"}],corrections:null},{id:"71352",title:"Management of Tourism Crisis in the Middle East",doi:"10.5772/intechopen.90174",slug:"management-of-tourism-crisis-in-the-middle-east",totalDownloads:681,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This study looks for to recognize the realism of management of tourism crisis in Jordan (Amman Hotels’ Bombing case study). In order to show the role of the management and its effects in facing the tourism crisis in Jordan, the researcher will try to handle a group of points: finding a special concept for tourism crisis, crisis generative environment, management of tourism crisis, and studying Jordan management of the Hotel bombing in Amman. To clarify and achieve the objectives of the research, the researcher adopted the descriptive analytical approach to what is stated in the most important books and references Arab and foreign periodicals, statistics, and official reports relating to the ethics of the research. It is recommended, in this study, to provide training opportunities for all people who have a role in the management of tourism crisis especially in the communication sector, the massive presence of police in the tourism site, hotels, and all the tourism places under the condition of not being seen, and to provide the qualified policemen with modern defensive weapons.",signatures:"Omar Jawabreh",downloadPdfUrl:"/chapter/pdf-download/71352",previewPdfUrl:"/chapter/pdf-preview/71352",authors:[{id:"311791",title:"Associate Prof.",name:"Omar",surname:"Jawabreh",slug:"omar-jawabreh",fullName:"Omar Jawabreh"}],corrections:null},{id:"70464",title:"Exploring the Three-Way Destination Safety Solution to Crisis Management in Tourist Destinations in Rural Nigeria",doi:"10.5772/intechopen.89727",slug:"exploring-the-three-way-destination-safety-solution-to-crisis-management-in-tourist-destinations-in-",totalDownloads:636,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Development of tourist destinations is among topical issues in national discourse for economic growth and sustainability. The past two decades have witnessed massive development and investment in tourist destinations in rural areas. This is owing to the fact that rural tourism has been identified as among the development options for rural communities in most developing nations. Of recent, crisis and other safety issues have been among the militating factors against tourist destinations hence the cry for destination safety. These are said to emanate from the activities of the three major principals in the management of tourist destinations (hosts, tourism resources, and tourists/visitors). Incidentally, destination safety discourse is source of worry for these principal factors in tourist destination management. This has left many tourist destinations devastated, abandoned and abused. However, this chapter proposal would seek to identify the way out of this predicament. It tends to explore the meaning and application of the three-way destination safety (TWaDeSS) model in the management of crisis at tourist destinations in rural Nigeria. This will not only promote harmony among the three major principals in tourist destination but also enhance the rate of investment as a result of quality crisis control in these destinations.",signatures:"Elochukwu A. Nwankwo",downloadPdfUrl:"/chapter/pdf-download/70464",previewPdfUrl:"/chapter/pdf-preview/70464",authors:[{id:"308906",title:"Dr.",name:"Elochukwu",surname:"Nwankwo",slug:"elochukwu-nwankwo",fullName:"Elochukwu Nwankwo"}],corrections:null},{id:"69310",title:"Crisis Management in Nigeria’s Public Sector and the Impact of the Organised Labour Union: Interrogating the Nexus between Industrial Harmony and Political Stability",doi:"10.5772/intechopen.89562",slug:"crisis-management-in-nigeria-s-public-sector-and-the-impact-of-the-organised-labour-union-interrogat",totalDownloads:467,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This study sought to explore the dynamics in managing crisis in the Nigerian public sector and its engagement with the organised labour, with a view to determining the interface between industrial harmony and political stability in the country. This study is predicated on the fact that crisis management is essentially embedded in humanity. Additionally, the study was informed by the established and widely held view by scholars, that social groups by their nature and context, are in fact characterised by conflicts. Consequently, the study established that the public sector in every society is not immune against conflict or crisis, and this will naturally arise as long as there is interaction between and among human elements in the two sectors. The author used the terms—crisis and conflict—interchangeably in the study, and pointed out that the methodology adopted was a descriptive and analytical approach. This is informed by the sources of information accessed which are essentially secondary. The study concluded by asserting that given the humanity-linked nature of conflict, its management in the public sector, particularly in Nigeria, will continue to be an unavoidable responsibility of the government. This is to ensure that the right environment is created to guarantee smooth governance.",signatures:"Daniel Taye Medoye",downloadPdfUrl:"/chapter/pdf-download/69310",previewPdfUrl:"/chapter/pdf-preview/69310",authors:[{id:"455142",title:"Dr.",name:"Daniel",surname:"Medoye",slug:"daniel-medoye",fullName:"Daniel Medoye"}],corrections:null},{id:"71859",title:"The Police Development and Protection of Soft Targets",doi:"10.5772/intechopen.92072",slug:"the-police-development-and-protection-of-soft-targets",totalDownloads:628,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This paper describes the function and development of the requirements for modern and high-quality equipment and accessories and also equipment used by the specialized units of the police force of the ČR with a practical example. 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With its innovative integration of convective and diffusive techniques, haemodiafiltration (HDF) enhances solute removal across a broad molecular-weight spectrum, which theoretically may improve patient outcomes. Solute clearance by convection requires substantial volumes of ultrafiltration, which in turn necessitates the administration of exogenous fluid replacement. Whilst this fluid may originate from multiple sources, current practice centres around the online generation of sterile, ultrapure dialysate which may be reinfused directly into the circulation. This process requires strict water quality and safety monitoring but enables reinfusion of unlimited volumes of substitution fluid, traditionally either before (pre-dilution HDF) or after (post-dilution HDF) the dialyser. In recent years, two novel HDF techniques (mixed- and mid-dilution HDF) have been developed which permit simultaneous pre- and post-dilution. Both the optimal ‘dose’ of convection and the ideal site of fluid reinfusion are yet to be determined. This chapter will discuss the evidence surrounding these topics in contemporary HDF practice.
\nConvective solute transport occurs due to the sieving of solutes across an open membrane in the context of large volumes of ultrafiltration. To achieve maximal convective flux, the volume of ultrafiltration must be optimised. The total volume of ultrafiltration is determined by the ultrafiltration rate and treatment time and is referred to as the convection volume. This value is related to, but distinct from, the substitution volume, which is the quantity of replacement fluid reinfused into the circuit. The difference between the two represents the net fluid removal during the treatment.
\nSignificant changes in the magnitude of the convection volume have taken place since the inception of HDF in the 1970s. Classic HDF used an average substitution volume of 9 L per session, which was primarily limited by cost and logistical issues associated with commercially produced replacement fluid. This is comparable to the estimated amount of convection that occurs during high-flux haemodialysis (HD) today. Most recently, innovations in fluid generation have allowed online production of substitution fluid, which has facilitated convection volumes of 25–40 L per session (and up to 60 L, depending on the mode). This advance has revolutionised the practice of HDF and has piqued interest in the modality worldwide. Importantly, parallel advances in fluid balancing systems have permitted the safe and accurate regulation of ultrafiltration, even at these exceptionally high volumes.
\nRecently, EUDIAL has set a minimum convection volume for a treatment to be classified as HDF. This threshold is equivalent to 20% of the total processed blood volume [1]. For example, a 4-h treatment with a blood flow rate of 350 ml/min (~84 L/treatment) must have a minimum convection volume of 17 L. Below this, the treatment would be classified as high-flux HD. In general, the convection volume in the post-dilution HDF should be between 17 and 27 L per session [2].
\nDue to the obvious impact on solute clearance efficiency, the convection volume must be standardised according to the site of fluid reinfusion. This corrected value is termed the
The maximal achieved convection volume is dependent on several patient- and treatment-related factors, the most important of which are treatment time and blood flow rate (Table 1). Other determinants include the transmembrane pressure gradient (TMP), specific characteristics of the dialyser (e.g. membrane surface area, UF coefficient, capillary dimensions, biocompatibility), haematocrit and serum albumin [3, 4]. The term
High blood flow rate | \n|
Long treatment time | \n|
High filtration fraction | \n|
Large membrane surface area | \n|
Biocompatible dialyser | \n|
High UF co-efficient | \n|
Hypoalbuminaemia | \n|
Poor vascular access | \n|
High haematocrit | \n|
Small calibre membrane fibres | \n
Determinants of convection volume.
Whilst an overall survival benefit favouring convective therapies has not been established, several studies have supported a ‘dose–response’ relationship between convection volume and survival (Table 2). The Dialysis Outcomes and Practice Patterns Study (DOPPS) first suggested this effect when it showed a 35% relative risk (RR) reduction in mortality between HDF with substitution volumes of 15–25 L and low-flux HD [5]. Since then, there have been three large randomised controlled trials published with similar findings—the CONvective TRAnsport STudy (CONTRAST) [6], the Turkish HDF study [4] and the Estudio de Supervivencia de Hemodiafiltración On-Line (ESHOL) study [7]. In the post hoc analyses of the CONTRAST and the Turkish HDF study, patients with the highest convection volumes were shown to have a survival benefit [4, 8]. In CONTRAST, this difference was seen in the tertile of patients treated with convection volumes >21.95 L (hazard ratio (HR) 0.61) and in the Turkish HDF study, it was seen in patients with a substitution volume >17.4 L (HR 0.54). The ESHOL study demonstrated a similar dose–response effect in its primary analysis: patients treated with convection volumes above 23.1 L had improved all-cause and cardiovascular mortality (HR 0.60) with a further improvement seen at convection volumes >25.4L (HR 0.55) [7]. Further supporting a dose-dependent effect, a pooled analysis of CONTRAST, the Turkish HDF study, the ESHOL study and a French HDF study demonstrated a statistically significant reduction in all-cause mortality in patients receiving the highest convection volumes (24.4–27.4 L) compared with standard HD [8].
\nThe effect of cumulative convection dose on survival has recently been investigated by a retrospective observational study of incident HDF patients. They showed an association between weekly convection volume and survival which began to be apparent at 55 L/week (30 L/week/m2) and plateaued at 70–75 L/week (40–45 L/week/m2) [9]. This is the first paper to recognise the importance of cumulative treatment dose, taking into account session frequency, which may be particularly relevant to mortality outcomes.
\n\n | Substitution volume | \nConvection volume | \nRR or HR (CI) | \n
---|---|---|---|
>15 L/session | \n>17.5 L/session | \n0.65 | \n|
>19.45 L/session | \n>21.95 L/session | \n0.61 (0.38–0.98) | \n|
>17.4 L/session | \n>19.9 L/session | \n0.54 (0.31–0.93) | \n|
20.6–22.9 L/session >22.9 L/session | \n23.1–25.4 L/session >25.4 L/session | \n0.60 (0.39–0.90) 0.55 (0.34–0.84) | \n
Volumes required to achieve a reduction in mortality (expressed as RR or HR with confidence interval (CI), and assuming an average net fluid removal of 2.5 L).
Assessment of HDF adequacy must take into account removal of solutes across all molecular weights. Specifically, enhanced middle- and large-molecule clearance should not occur at the expense of inferior small-solute clearance. For practical purposes, small-solute clearance should be quantified using the same approach as for HD, whether that be calculation of Kt/Vurea or percentage reduction in urea. Of note, blood samples must be taken upstream of any fluid reinfusion port to avoid sample dilution. This is especially relevant in the pre-dilution and mixed-dilution HDF modes where substitution fluid is infused before the dialyser. In terms of assessing middle-molecule clearance, convective dialysis ‘dose’ appears to be a linear function of substitution volume so reporting of this value is routinely used [11, 12].
\nDue to the indiscriminate nature of solute removal by large-volume ultrafiltration, inadvertent removal of beneficial solutes is unavoidable. The most significant example of this is albumin. The degree of albumin loss in a HDF treatment is dependent on the membrane type, ultrafiltration volume and TMP. The site of fluid reinfusion is also relevant as a key determinant of ultrafiltration volume and TMP; the use of post- and mid-dilution HDF may increase the loss of albumin up to fivefold [12]. Albumin removal can be minimised by profiled filtration modes, which limit initial filtration, or by regulated TMP control. Fortunately, as described in the randomised trials and observational studies, albumin loss did not appear to affect nutritional parameters or serum albumin concentration [4, 6, 9, 10, 13]. It should therefore not limit the utilisation of HDF or the prescribed convection volume in current practice, but will require ongoing evaluation in future trials given the lack of robust safety data.
\nThe requisite ‘dose’ of convection likely varies between individuals. This in turn has theoretical implications for future trial design and practical implications for HDF prescription. Two important patient characteristics that should be considered are patient size and residual renal function [1]. Having an absolute convection volume target for all patients is not logical since patients vary widely in size, body composition and metabolic rate. Recently, the HDF Pooling Project Investigators looked at the effect of convection volume on mortality when stratified convection volumes were standardised according to patient size. The survival advantage for higher convective dose was maintained after standardising for total body water and body surface areas, which are surrogate markers of lean body mass, but not for body weight or body mass index [8]. Other patient factors may also be important in determining optimal convection volume including age, ethnic background, comorbidity index, diabetic status and dialysis vintage. The importance of these additional factors is yet to be studied.
\nThe degree of ultrafiltration that occurs in HDF necessitates reinfusion of large volumes of replacement fluid into the extracorporeal circuit. This fluid must be sterile and non-pyrogenic with a biochemical composition similar to plasma water. The replacement fluid may be obtained in two ways: internal substitution (e.g. internal filtration HDF, push–pull HDF, double high-flux HDF and paired filtration dialysis) or external substitution (e.g. classic HDF and online HDF).
\nInternal filtration HDF uses pressure profiling to take advantage of the substantial volumes of plasma water that can be filtered across high-flux dialysers. Difference in pressure between the blood and dialysate compartments results in proximal ultrafiltration followed by distal backfiltration (Figure 1). Backfiltration of dialysate is analogous to reinfusion of substitution fluid. Sudden shifts in plasma water may lead to increased rates of haemolysis. Backfiltration poses an additional risk of biological and endotoxin contamination; however, the use of dialysis membranes with a high endotoxin retention capacity minimises this risk.
\nPush–pull HDF involves rapid alternations in ultrafiltration and backfiltration across a single high-flux dialyser using a double-pump system installed on the effluent line (Figure 1). These alternations are controlled by fluctuations in pressure that occur due to varying the volume of the dialysate compartment. Fluid is reinfused along the course of the dialyser, favouring the blood outlet port where the pressure in the blood compartment is lowest. The convection volume may be as high as 120 L throughout a standard 4 h treatment [14]. Albumin loss is significantly lower than In post-dilution HDF due to lower TMP [15]. Intermittent backfiltration removes protein deposition on the blood side of the membrane making this technique also suitable for extended-hour renal replacement therapy (e.g. nocturnal or continuous HDF).
\nInternal filtration HDF and push-pull HDF.
Double high-flux HDF consists of two high-flux membranes connected in series and subjected to high blood and dialysate flow rates (Figure 2). Simultaneous diffusion and convection occur across the first membrane, whilst backfiltration of sterile dialysate occurs across the second. Variation in pressure and flow across the two dialysers is controlled by a resistance valve. Using this system, von Albertini was able to achieve 13 L convection per 2 h treatment and significant clearances of both small and larger solutes [16].
\nPaired filtration dialysis uses two high-flux membranes connected in series. The first is a haemofilter with a small surface area, which performs ultrafiltration, and the second is a haemodialyser which performs diffusion. The substitution fluid is infused between the two. The main variation of this technique is paired filtration dialysis with endogenous reinfusion. This is also referred to as haemodiafiltration with endogenous reinfusion (HFR): In HFR, ultrafiltrate passes through a purifying charcoal/resin filter before being reinfused as substitution fluid (Figure 2).
\nDouble high-flux HDF and paired filtration dialysis with endogenous reinfusion.
Classic HDF consists of a single dialyser which performs haemodiafiltration. The convection volume is replaced with packaged, commercially produced substitution fluid which is reinfused after the dialyser (Figure 3). This practice is associated with significant expense and obvious logistic issues [17]. These factors limit the volume of convection and therefore solute clearance.
\nClassic HDF.
Online HDF relies on the ability of modern dialysis machines to generate unlimited quantities of ultrapure dialysis fluid, which can be reinfused directly into the circulation. In this system, dialysis fluid is prepared by the proportioning of ultrapure water and a concentrated electrolyte solution. This fluid is then used as both dialysate and substitution fluid (Figures 6 and 7). The integrity of the chemical composition is monitored using conductivity measurements. First described in the 1970s, the development of online fluid generation has facilitated the evolution of HDF from low-volume to high-volume practice [18]. It has been commercially available for over a decade and comes at minimal additional cost compared to high flux HD. This modality is the most widely utilised HDF technique in contemporary dialysis. It is well established in Europe and Japan, and is experiencing escalating use in Australia and New Zealand (currently representing 16% of haemodialysis modalities) [19].
\nSince significant quantities of substitution fluid are being reinfused directly into the blood circuit, strict biological safety is essential. Many countries have specific policies outlining the technical requirements and water monitoring processes that dialysis units must comply with to practice HDF. Additionally, international guidelines exist which underpin the minimum standards for microbiological and chemical quality [20]. These technical requirements include the use of specific HDF machines and the ability to generate ultrapure water and dialysis fluid (Table 3). Generation of ultrapure water involves a pre-treatment system (microfiltration, softeners, activated carbon) followed by two reverse osmosis modules connected in series (Figure 4). In some water treatment systems, the reverse osmosis modules will be followed by a storage tank.
\n\n | Regular water | \nUltrapure water | \nUltrapure dialysate | \n
---|---|---|---|
<100 CFU/ml | \n<0.1 CFU/ml | \n<0.1 CFU/ml | \n|
<0.25 IU/ml | \n<0.03 IU/ml | \n<0.03 IU/ml | \n
Water purity definitions.
Conversion of tap water to ultrapure water.
Ultrapure water is converted to ultrapure dialysis fluid by combination with an electrolyte concentrate. The fluid then undergoes cold sterilisation, a process involving a series of filters with bacterial and endotoxin retentive properties at intermediate points in the circuit. An inbuilt infusion pump diverts a proportion of ultrapure dialysate through another safety filter prior to being directly infused into the patient’s bloodstream as replacement fluid (Figure 5).
\nConversion of ultrapure water to ultrapure dialysate.
Beyond the actual production of ultrapure dialysate, frequent disinfection of the water treatment system and dialysis machine, Thermochemical destruction of the biofilm, regular change of filters and maintenance of a permanent circulation of water are essential. Microbiological and endotoxin monitoring must also be carried out.
\nSeveral clinical studies have confirmed the safety of online HDF provided that appropriate CE marked and certified HDF machines are used and the best clinical practices are applied [21]. The three largest RCTs comparing HDF to HD did not demonstrate any higher incidence of infectious complications using online fluid generation [4, 8, 9].
\nOnline HDF modalities are classified according to the location at which the replacement fluid is administered in the extracorporeal circuit. The replacement fluid has traditionally been reinfused either before (pre-dilution) or after (post-dilution) the dialyser. Simultaneous pre- and post-dilution HDF techniques (mixed- and mid-dilution) have gained popularity in recent years. Each has relative advantages and disadvantages (Table 4). Other novel hybrid modalities have been proposed including ‘pre-dilution on demand’ and ‘backflush on demand’.
\n\n | Post-dilution | \nPre-dilution | \nMixed-dilution | \nMid-dilution | \n
---|---|---|---|---|
+++ | \n+ | \n+++ | \n++ | \n|
++ | \n+ | \n+++ | \n+++ | \n|
++ | \n+ | \n+++ | \n++ | \n|
++ | \n+ | \n+ | \n+++ | \n|
++ | \n+ | \n+ | \n+++ | \n|
++ | \n+ | \n+ | \n+++ | \n
Relative advantages and disadvantages of fluid reinfusion site.
Post-dilution HDF is regarded as the most efficient form of HDF in terms of solute clearance and is the most common format used in contemporary clinical practice. By reinfusing fluid after the dialyser, a continuous concentration gradient is maintained along the entire course of the dialyser (Figure 6). This approach has been shown to be superior to both high-flux HD and pre-dilution HDF in terms of small-solute and middle-molecule clearance [11, 22].
\nThe efficiency of solute clearance in this system occurs at the expense of escalating haemoconcentration, which increases the risk of filter clotting, membrane pore occlusion and a subsequent increase in TMP. In extreme cases, red cell damage and protein denaturation may occur. There is also an increased risk of albumin loss as a result of the high TMP. The potential for haemoconcentration means that the filtration fraction must be limited which in turn necessitates a high blood flow rate to achieve adequate convection (typically >350 ml/min). Therefore, in patients with poor vascular access, inadequate blood flow may compromise the ability to achieve satisfactory clearances. Similarly, the risk of filter clotting means that patients with high haematocrit, cryoglobulinemia or gammopathy should be preferentially managed with pre-dilution or mixed-dilution HDF.
\nIn pre-dilution HDF, the substitution fluid is reinfused before the entry of blood into the dialyser (Figure 6). This avoids complications relating to haemoconcentration which extends filter life and lowers TMP. Because of the lower risk of clotting, heparin dose can be minimised and heparin-free dialysis for high-risk patients is possible [23]. In Japan, where this technique is used most widely, improvements in shear stress, blood pressure and haematological parameters (especially neutrophil and lymphocyte function) have also been reported [24, 25]. This same group have described improvements in dialysis-related symptom burden including itch, restless legs syndrome and insomnia compared to the post-dilution HDF.
\nPre-dilution HDF has obvious deleterious effects on the efficiency of solute clearance. The reduced efficiency of this system means that ultrafiltration rates must be at least twofold higher than those in post-dilution HDF to achieve equivalent solute clearance. In fact, ultrafiltration rates of up to 100% of the blood flow rate are often used.
\nPost-dilution HDF and pre-dilution HDF.
In mixed-dilution HDF, fluid is simultaneously reinfused both before and after the dialyser in a ratio that is automatically regulated by the TMP and ultrafiltration feedback (Figure 7). An internal feedback mechanism maintains the TMP between 250 and 300 mmHg and ensures a maximum filtration fraction after considering the blood and dialysate flow, internal pressure and hydraulic permeability of the dialyser. Convection volume tends to be 30–40 L/session. TMP is calculated according to the pressure measured at four points in the system: blood entry into the dialyser entry (Pblood in), blood exit from the dialyser (Pblood out), dialysate entry into the dialyser (Pdialysate in) and dialysate exit into the dialyser (Pdialysate out).
\nRepresentation of the mixed-dilution and mid-dilution HDF.
If the TMP rises beyond its maximum tolerated value, a fraction of infused dialysate is diverted from post- to pre-dilution, which decreases haemoconcentration and lowers the risk of membrane pore occlusion. Similarly, if the TMP falls below the target range, fluid is redirected towards the post-dilution mode to increase system efficiency.
\nMixed dilution HDF has been shown to be non-inferior to post-dilution HDF in terms of small and protein-bound solute clearance and superior to post-dilution and pre-dilution HDF in terms of β2−microglobulin clearance (β2−M) [26–29]. Whilst these were relatively small randomised trials which require larger studies to confirm their findings, mixed-dilution HDF appears to offer an attractive balance between efficiency of solute removal and minimisation of haemoconcentration-related complications. Specifically, it may be suitable for patients in whom target convection volumes are not achieved by post-dilution HDF because of high haematocrit, high plasma protein, or inadequate vascular access and blood flow rate.
\nMid-dilution HDF similarly combines pre- and post-dilution fluid reinfusion into a hybrid system (Figure 7). It does so by utilising a specialised haemodiafilter, the Nephros OLpur MD 190. This filter is constructed in such a way that blood enters through the central core fibres of the dialyser and returns in the opposite direction peripherally. This model effectively comprises two dialysers in series. Substitution fluid is incorporated at the midpoint of the system, which creates an initial post-dilution stage followed by a pre-dilution stage. This enables a high-concentration gradient and encourages movement of small solutes in the first stage and maximal ultrafiltration of plasma water and convective removal of larger molecules in the second stage. Reinfusion rates up to 10–12 L/h are possible.
\nUnfortunately, due to the nature of the specialised dialyser, mid-dilution HDF is associated with higher costs. There is also a higher degree of albumin loss, which is not insignificant. Concerns exist regarding generation of a high TMP, which could compromise membrane permeability. A TMP of up to 1000 mmHg has been reported as necessary to achieve the required minimum ultrafiltration of 6 L/h [30]. This high TMP is especially problematic in the first section of the dialyser where the post-dilution phase takes place and is thought to be the result of partial fibre clotting and increased resistance to blood flow due to the reduced capillary diameter in this segment [31]. Given the pro-coagulant effect of rapid convection, adequate anticoagulation is necessary to ensure device patency. Reversal of the configuration of the blood tubing (i.e. connecting the arterial line to the venous port of the dialyser and vice versa) has been successfully trialled in mid-dilution HDF without significant effect on plasma clearances if adequate infusion rates are maintained [32, 33]. Consideration should also be given to the use of larger-surface filters (e.g. Nephros OLpur MD 220) [34].
\nWhen compared to post-dilution HDF, mid-dilution HDF is associated with inferior small solute but superior middle-molecule clearance (β2M, myoglobin, prolactin, RTP) and similar clearance of protein-bound solutes [35–37]. With increasing molecular weight, differences in treatment efficiency between mid- and post-dilution HDF rise [36]. Phosphate clearance is similar between the two groups. Whilst few studies have compared mid- and mixed-dilution HDF, one small prospective randomised trial found greater small-solute and middle-molecule clearance with mixed-dilution HDF though differences in dialyser membranes may have confounded their outcomes [30]. Another small prospective crossover study compared ‘simple mid-dilution’ (using two dialysers in series, rather than the Nephros OLpur MD 190) and mixed-dilution HDF. They similarly found that mixed-dilution HDF provided significantly greater clearances of urea, creatinine and β2M compared To ‘simple mid-dilution’ HDF with equivalent phosphate clearances [38]. These outcomes require examination in larger trials.
\nTwo novel systems, ‘
Many questions remain unanswered in the field of fluid convection, generation and reinfusion in haemodiafiltration. Although convection volume appears to have a dose-dependent relationship with survival, randomised trials have failed to consistently demonstrate improved mortality in their primary analyses. Furthermore, the critical ‘dose’ required to improve patient outcomes is yet to be determined and may need to be individualised according to patient factors, including patient size and residual renal function. Online generation of ultrapure dialysate has revolutionised the practice of HDF by allowing large convection volumes, although this approach requires strict monitoring in terms of quality and safety. The preferred site of fluid reinfusion is not known and warrants careful consideration of the opposing factors of solute clearance efficiency and the consequences of haemoconcentration. Hybrid modalities appear to present a promising balance between the two. Given the lack of robust clinical trials confirming the benefits of HDF, the increasing uptake of HDF worldwide has largely been driven by industry. Lack of a harm signal, cost neutrality and optimism that patient benefits will arise from large convective volumes have facilitated acceptance amongst the Nephrology community. It is unclear whether high-quality data from randomised trials will be available to guide convection and reinfusion strategies and it is likely that practice will need to rely on the results of observational studies.
\nA slope is an inclined ground surface formed naturally or by excavation for different human activities. Its stability is the major consideration in civil engineering infrastructural projects such as open-pit mining operations, road cut or embankment slopes as its failure causes considerable damage on the infrastructure, human life and property.
Instability of slope can be occurred due to internal or external factors which causes failure either by reducing the shear strength of slope material or by increasing the shear stress on the slope [1]. Different processes such as increased pore pressure, cracking, swelling, decomposition of clayey rock fills, creep under sustained loads, leaching, weathering, and cyclic loading are responsible to a reduction in shear strengths [2]. In contrast to this, the shear stress in slopes may increase due to additional loads at the top of the slope, increase in water pressure, increase in soil weight due to saturation, excavation at the bottom of the slope, and seismic effects [1]. Also, it must be noted that, slope geometry, state of stress, and erosion contributes to the failure of slope. The mechanism of slope failure varies and takes place as speed or slow rate, depending on the type of material, slope geometry, and types of triggering factors. Slide, fall, earth flow, debris flow, topple, planar and wedge failure are the common methods of slope failure.
As both natural and human activities are responsible for the failure of slopes, it is difficult to avoid the problem entirely. However, the level of damage can be significantly reduced by assessing the stability condition and adopting different preventive measures on it. There are various remedial measures applied during and after construction to reduce the impact of slope failure and these can be grouped into four general classes i.e. geometric modification, drainage control, slope reinforcement, and retaining structure [3].
Now a day slope stability studies have been attracted researcher’s attention as their understanding on the impact of slope failure in human life and infrastructural development increases. Numerous slope stability studies were carried around the world so far and better understandings are established about causes of failure, mechanisms of failure, methods of analysis, and possible remedial measures. However, the damages due to slope failure are increasing from year to year and still the major difficulty for the development of infrastructural constructions in Ethiopia. A review of previous slope stability assessments [4, 5, 6] indicates that slope failures are the main constraint for road and railway construction in Ethiopia. To overcome this problem and acquire better solutions a continuous effort is needed. Hence, this study was carried to evaluate the performance of geometric modification i.e. slope profiles (single slope, multi slope and multi slope) on slope stability using numerical methods.
The study area is located at Adama city in Ethiopia on a newly constructed ring road project. The area is in the east African refit valley system which is dominated by escarpments of various landscapes and bordering. The slope is formed by excavation of volcanic ridges and its height extends up to 40 m with 3 m bench every 10 m. Reddish to brownish color residual soils formed by a physical and chemical process from parent rock and volcanic rocks of different degree of weathering are the major type of materials found in the cut slope (Figure 1).
Location of the study area and slope section of the road.
Geometry is among the most critical factors controlling the stability of the slope [7, 8]. Generally, slope height, slope angle and slope profile are the major parameters in geometric modification. Cut and embankment slopes can be formed using one of the three profiles i.e. single slope, multi slope and bench slope. But depending on the composition of slope material, height of the slope, and hydrological conditions these profiles have different performance in the stability of slope.
Single slope profile is used in cut and embankments of dense soils with enough resistance against failure with a limited height [9]. Increasing height (h) and angle of slope (α) will increase the shear stress and decrease normal stress on the potential rupture plane [2]. As a result, h and α are major parameters control the performance of single slope profile.
Multi-sloped profiles are provided in cuts where the stratigraphy of soil consists of two or more layers with different strength characteristics [9]. The method allows the use of both steep and gentle slopes in stiff and weaker layer of the slope section respectively.
Bench slope profile is a technique in which the overall slope is divided into multiple small slopes. It reduces the driving forces above the failure surface by reducing the weight of slope [8]. Bench slope, bench height and bench width are the major parameters control the performance of bench slopes (Figure 2).
Geometric profiles of cut slope.
To investigate the performance of slope profiles a newly constructed road cut slope in Adama city was used. Under this investigation the effect of slope profiles and its parameters (slope height, slope angle, bench width, no of bench, and bench angle) on the stability of slope was evaluated interims of FS and deformation. The performance of multi-slope and bench slope profiles was evaluated with respect to single slope profiles and further comparison was made between them interims of construction difficulty, appearance or esthetic value, drainage control, and accessibility for maintenance.
For this FE modeling an elastic perfectly plastic Mohr-Coulomb material model was used. The model uses material stiffness (E and v) as elasticity parameter, material strength (𝜑, and c) as soil plasticity and 𝜓 as angle of dilatancy [10]. The slope section used for this investigation has both soil and rock layers, hence to determine the parameters both field and laboratory tests were carried. The soil shear strength parameters were obtained from direct shear test and its stiffness parameters were correlated with SPT data. Similarly, the strength and deformation parameters of rock layers were determined by correlating field and laboratory tests with rock data software. The geometric and material data used for this investigation were summarized in Figure 3 and Table 1.
Cross-section of the newly constructed road cut slope.
Sample code | Description of soil and rocks | C (kN/m2) | E (MPa) | V | ||||
---|---|---|---|---|---|---|---|---|
SSC-22 | Clayey sand | 20.1 | 16.4 | 14.57 | 27.89 | 0 | 25 | 0.215 |
SSC-21 | Sand with clay and gravel | 20.1 | 16.6 | 9.7 | 35.75 | 5.75 | 35 | 0.261 |
RSC-11 | Slightly to moderately weathered rock | 21.3 | 20.1 | 130 | 29.21 | 0 | 1962.8 | 0.35 |
RSC-12 | Highly weathered rock | 19.8 | 18.7 | 600 | 20.32 | 0 | 686.9 | 0.38 |
Material properties used in numerical modeling.
To evaluate the stability of slope in different profiles first initial stress and pore water pressure distribution was generated using 𝑘0 procedure and phreatic water level respectively. Then the deformation and safety analysis were carried with plastic calculation and phi-c reduction method for the same loading conditions. Phi-c reduction is a method where the shear strength parameters (c and tan∅) are successively reduced until the failure occurs [13]. During the process the strength reduction factor (∑ 𝑀𝑠𝑓) is increased start from 1. The global safety factor is equal to the total multipliers ∑ 𝑀𝑠𝑓 at the point of failure which is expressed as the ratio of initial and reduced strength parameters [10].
To validate the numerical model a slope section for this study was evaluated using Fellenius method (analytical solution) and the result was compared with numerical value both in FEM (plaxis) and LEM (slide) software’s (Figure 4).
FS determination using analytical solutions.
Validation also made using slope section first introduced by Zhang [14] and later used by numerous investigators i.e. Ferdlund and Krahn [15], Chen et al. [16], Griffiths and Marquez [17], Zhang et al. [18], and Chaowei et al. [19] to validate their 2D and 3D slope stability evaluations (Figure 5). The section was modeled using a slide, Plaxis-2D, and Plaxis-3D software with the same material and boundary condition. The result in Figure 6 shows a drift of ± 5% from previous investigators. Generally, from both validations the result from numerical modeling shows good agreement with the analytical solution and the previous works.
Modeling of slope section used for validation in slide, Plaxis-2D, and Plaxis-3D.
FS from different researchers and this study on Zhang [
Increasing angle and height of slope affects the stability by increasing the shear stress and decreasing shear strength on the potential rupture plane. To examine the effect of these parameters numerical models on Figure 3 was made for different slope height and slope angles.
Figure 7A shows FS of slope for 27°, 34°, 45°, 63°, and 73° (i.e. increasing slope angle reduces the FS). Similarly, Figure 7B shows the effect of slope height on FS in an ideally sandy lean clay slope for different slope heights (i.e. increasing slope height increases the deformation and decrease the FS of the slope). Hence it is recognized that both slope height and slope angle reduce the FS of slope in the same principle i.e. increasing self-weight (driving force) above the failure surface and decreasing the normal force on the failure surface.
Effect of slope angle and slope height on the performance of single slope profile.
Bench width, cut angle and no bench are the major parameters which control the performance of bench slope profile. To examine the performance of benching and its parameters on the stability of slopes a typical slope section given in Figure 3 was used. Figure 8A shows the FS of slope for 1, 2, 3, 4, 5 and 6 m bench width with a constant 10 m bench height. As the figure indicates stability increases with increasing bench width (i.e. FS increases in 3.5%, 7.7%, and 12% from single slope profile in 1:1 slope ratio for 1 m, 2 m and 3 m bench widths respectively). The percentage change of FS from equivalent single slope profile is 1.7%, 3.6%, 7.7% and 17.4% for 27°, 34°, 45° and 63° respectively in a constant 2 m bench width as shown in Figure 8B. Hence the use of benching is more effective in steep slopes.
Effect of bench width, bench slope and bench height on the performance of bench slope profiles.
Similarly, the effect of bench height was evaluated using uniform clayey sand soil in two cases (i.e. case 1, when the overall cut varies with constant slope within bench. Case 2, when overall cut is constant with varied slope within bench as shown in Figure 8C). Accordingly, decreasing bench height (increasing no of bench) increases the FS of slope in case 1. However, it has no significant effect in case 2. Generally, benches improve stability of slope in the opposite principle of slope height and slope angle by decreasing the driving force of the slope above the failure surface. The method is effective to avoid the use of gentle and high slopes in the design of cut slope.
To assess the performance of multi slope profile in stratified soils a layered slope section shown in Figure 3B is evaluated for different combinations of slope angle (i.e. in the weaker and stronger section). Table 2 and Figure 9 shows FS for different combination of weaker and stiffer slope section. Accordingly, FS is improved up to 30% from a single slope profile by adjustment of cut angle (i.e. decreasing weaker section and increasing stiffer section). But it should be reminded that the amount of change in FS depends on the strength characteristics of the slope section. Generally, multi slope profile allows the use of steep and gentle slope in stiff and loses materials respectively in stratified soil.
Slope | a (stronger layer) | 45 | 48 | 51.3 | 55 | 59 | 63.4 | 68 | 78.67 | 90 |
b (weaker layer) | 45 | 42.3 | 39.8 | 37.5 | 35.5 | 33.69 | 32 | 29 | 26.5 | |
FS | 1.202 | 1.251 | 1.325 | 1.414 | 1.472 | 1.513 | 1.55 | 1.5 | 1.45 |
FS for different combination multi-slope profiles (a= stronger slope & b= weaker slope).
FS and its change from single slope in % for d/t combination of multi-slope profiles.
Further comparison was made on the performance of profiles by evaluating the slope section in Figure 10A for single, multi, bench slope and combination both. Figure 10B shows the result of the comparison i.e. FS changes in 13%, 22.7%, and 37.5% from single slope profile in bench, multi-slope, and the combinations of both methods respectively. Hence the use of bench slope, multi slope and combination them provide effective stability in high and stratified slope.
FS and deformation for different slope profiles.
From the above evaluation, it is recognized that modification of slope geometry is one and the very first economical alternative of slope stability improvement. Although this investigation is made in a specific type of slope material there is no doubt in the role of geometric modification in slope stability. However, the selection of these slope geometry should depend on site-specific parameters i.e. susceptibility of the slope to erosion and infiltration, the variability of slope material, the height of slope, and adjacent area of the slope.
According to the evaluation result, the use of a single slope profile is effective in homogenous stiff slope material when the height of the slope is low. Otherwise, the method may not be safe and economical choice as weak and high slope sections need very gentle slopes. Multi slope profiles are suitable in slopes where there is material strength variability. It provides a very economical slope design without extra excavation by making adjustments only within the slope section. Especially the method is ideal in slopes comprise both rock and soil. The use of bench is an effective geometric measure when the height of the slope is large. It increases FS by reducing the driving force above the failure surface. In addition to this the use of bench slope can provide the following advantages. (1) It reduces the area of the slope exposed to rainfall infiltration as it allows the use of steep slope between every benching. (2) It provides effective drainage control by collecting the rainwater from each slope profile and draining it laterally to ditches. (3) It provides access to side slopes for maintenance, plantation of vegetation, and decoration. (4) It uses for collection of debris falls above it. (5) It provides esthetic value and better appearance for slopes especially when it located around towns. In general slope profiles have advantages and limitations depending on site specific conditions as shown in Figure 11.
Advantages and limitations of slope profiles.
The performance evaluation of slope profiles in this study was made for the objective of creating awareness on the effect and its suitable condition of different geometric profiles on slope stability. The effect of geometric parameters like slope height, slope angle, bench width, no of bench and bench angle on slope stability were evaluated interims of FS and deformation on selected critical slope sections from the newly constructed road cut slope. From the result, it has been seen that geometric modification will provide better and economical slope stability compared to other structural remedies.
Accordingly, the stability of slope decreases with an increase in slope height and slope angle in single slope profile leading to an uneconomical design of high slopes in a single slope profile. Benching provides an important stability for cut slope especially for slopes having larger height and its performance is more effective in steep slopes. Bench width and bench height also parameters which affect the performance of benching. Multi-slope profile provides an effective slope stability in a stratified soil of varied strength. It allows economical slope design without extra excavation by making adjustments only within the slope section. In addition to its direct effect on the FS, slope profiles have different performance on drainage control, access to maintenance, and its esthetic value. Therefore, the selection of slope profiles during design should be based on site-specific considerations.
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\\n\\n1. RETRACTIONS
\\n\\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\\n\\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\\n\\nPublishing of a Retraction Notice will adhere to the following guidelines:
\\n\\n1.2. REMOVALS AND CANCELLATIONS
\\n\\n2. STATEMENTS OF CONCERN
\\n\\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\\n\\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\\n\\n3. CORRECTIONS
\\n\\nA Correction will be issued by the Academic Editor when:
\\n\\n3.1. ERRATUM
\\n\\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\\n\\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n3.2. CORRIGENDUM
\\n\\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\\n\\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
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Medicine",slug:"diagnostic-of-drowning-in-forensic-medicine",totalDownloads:8213,totalCrossrefCites:9,totalDimensionsCites:18,abstract:null,book:{id:"243",slug:"forensic-medicine-from-old-problems-to-new-challenges",title:"Forensic Medicine",fullTitle:"Forensic Medicine - From Old Problems to New Challenges"},signatures:"Audrey Farrugia and Bertrand Ludes",authors:[{id:"34146",title:"Dr.",name:"Audrey",middleName:null,surname:"Farrugia",slug:"audrey-farrugia",fullName:"Audrey Farrugia"},{id:"49284",title:"Dr.",name:"Bertrand",middleName:null,surname:"Ludes",slug:"bertrand-ludes",fullName:"Bertrand Ludes"}]},{id:"19160",doi:"10.5772/18161",title:"Death Scene Investigation from the Viewpoint of Forensic Medicine Expert",slug:"death-scene-investigation-from-the-viewpoint-of-forensic-medicine-expert",totalDownloads:27448,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"243",slug:"forensic-medicine-from-old-problems-to-new-challenges",title:"Forensic 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Dogan"},{id:"32211",title:"Dr.",name:"Serafettin",middleName:null,surname:"Demirci",slug:"serafettin-demirci",fullName:"Serafettin Demirci"}]},{id:"57199",title:"Negative Autopsy in Infant and Juvenile Population: Role of Cardiac Arrhythmias",slug:"negative-autopsy-in-infant-and-juvenile-population-role-of-cardiac-arrhythmias",totalDownloads:1417,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Negative autopsy is a post-mortem examination in which a comprehensive analysis does not provide a cause of death. These include situation of death, anatomical and histological analysis, toxicology and microbiological study. A low part of autopsies remain without a conclusive cause of death, but all these cases are usually seen in young population, apparently healthy who died suddenly and unexpectedly. In these situations a cardiac arrhythmia is suspected as cause of death and genetic testing is recommended despite not regularly performed. Sudden death is a natural and unexpected decease that occurs in apparently healthy people, or whose disease was not severe enough to expect a fatal outcome. It can be due to several pathologies, usually of cardiac cause and called sudden cardiac death. In infants and young people, both long QT syndrome and catecholaminergic polymorphic ventricular tachycardia are main causes in negative autopsies. These genetic diseases lead to ventricular fibrillation, syncope and sudden cardiac death in a normal heart. Unfortunately, sudden cardiac death could be the first manifestation of the diseases, being early identification and prevention a crucial point in current medical practice. This chapter focuses on sudden death and negative autopsy in young population, mainly due to cardiac arrhythmias.",book:{id:"6262",slug:"post-mortem-examination-and-autopsy-current-issues-from-death-to-laboratory-analysis",title:"Post Mortem Examination and Autopsy",fullTitle:"Post Mortem Examination and Autopsy - Current Issues From Death to Laboratory Analysis"},signatures:"Georgia Sarquella-Brugada, Sergi Cesar, Anna Fernandez-Falgueras,\nMaria Dolores Zambrano, Anna Iglesias, Josep Brugada, Ramon\nBrugada and Oscar Campuzano",authors:[{id:"54165",title:"Prof.",name:"Ramon",middleName:null,surname:"Brugada",slug:"ramon-brugada",fullName:"Ramon Brugada"},{id:"54168",title:"Dr.",name:"Oscar",middleName:null,surname:"Campuzano",slug:"oscar-campuzano",fullName:"Oscar Campuzano"},{id:"218478",title:"Dr.",name:"Georgia",middleName:null,surname:"Sarquella-Brugada",slug:"georgia-sarquella-brugada",fullName:"Georgia Sarquella-Brugada"},{id:"218479",title:"Dr.",name:"Sergi",middleName:null,surname:"Cesar",slug:"sergi-cesar",fullName:"Sergi Cesar"},{id:"218480",title:"MSc.",name:"Anna",middleName:null,surname:"Fernandez-Falgueras",slug:"anna-fernandez-falgueras",fullName:"Anna Fernandez-Falgueras"},{id:"218482",title:"Dr.",name:"Maria Dolores",middleName:null,surname:"Zambrano",slug:"maria-dolores-zambrano",fullName:"Maria Dolores Zambrano"},{id:"218483",title:"MSc.",name:"Anna",middleName:null,surname:"Iglesias",slug:"anna-iglesias",fullName:"Anna Iglesias"},{id:"218484",title:"Prof.",name:"Josep",middleName:null,surname:"Brugada",slug:"josep-brugada",fullName:"Josep Brugada"}]},{id:"57778",title:"Defining Dental Age for Chronological Age Determination",slug:"defining-dental-age-for-chronological-age-determination",totalDownloads:2606,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Dental age assessment is one of the most reliable methods of chronological age estimation used for criminal, forensic and anthropologic purposes. Visual, radiographic, chemical and histological techniques can be used for dental age estimation. Visual method is based on the sequence of eruption of the teeth and morphological changes that are caused due to function such as attrition, changes in color that are indicators of aging. Radiographs of the dentition can be used to determine the stage of dental development of the teeth from initial mineralization of a tooth, crown formation to root apex maturation. Histological methods require the preparation of the tissues for detailed microscopic examination. The chemical analysis of dental hard tissues determines alterations in ion levels with age, whereas the histological and chemical methods are invasive methods requiring extraction/sectioning of the tooth. In this chapter, the different techniques and considered studies were overviewed in conjunction with their advantages and disadvantages. It needs to be taken into consideration that rather than restricting on one age estimation technique, using the other available techniques additionally and performing repetitive measurements may be beneficial for accurate age estimation.",book:{id:"6262",slug:"post-mortem-examination-and-autopsy-current-issues-from-death-to-laboratory-analysis",title:"Post Mortem Examination and Autopsy",fullTitle:"Post Mortem Examination and Autopsy - Current Issues From Death to Laboratory Analysis"},signatures:"Fatma Deniz Uzuner, Emine Kaygısız and Nilüfer Darendeliler",authors:[{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner"},{id:"200985",title:"Dr.",name:"Emine",middleName:null,surname:"Kaygisiz",slug:"emine-kaygisiz",fullName:"Emine Kaygisiz"},{id:"222232",title:"Prof.",name:"Nilufer",middleName:null,surname:"Darendeliler",slug:"nilufer-darendeliler",fullName:"Nilufer Darendeliler"}]},{id:"77222",title:"Forensic Analysis and Interpretation of Tool Marks",slug:"forensic-analysis-and-interpretation-of-tool-marks",totalDownloads:537,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The forensic analysis and interpretation of tool marks raise for consideration key methods and advances in the field of tool marks in forensic science. This chapter shows how tool mark analysis can be utilized in the course of criminal investigations. The focus of the chapter is on bringing together as much scientific knowledge in the area as possible in an accessible manner. It covers all aspects of tool mark evidence from the crime scene to the courtroom. This chapter provides information about tool marks in an effort to assist tool mark examiners as well as people practicing forensic science, crime scene examiners, crime investigating officers and members of the legal profession. It includes information about the analysis of tool marks at the crime scene and in the laboratory, the interpretation and assessment of challenges for examination and interpretation and also the way in which tool mark evidence can be presented in a courtroom.",book:{id:"10579",slug:"forensic-analysis-scientific-and-medical-techniques-and-evidence-under-the-microscope",title:"Forensic Analysis",fullTitle:"Forensic Analysis - Scientific and Medical Techniques and Evidence under the Microscope"},signatures:"Sachil Kumar, Geetika Saxena and Archana Gautam",authors:[{id:"335909",title:"Assistant Prof.",name:"Sachil",middleName:null,surname:"Kumar",slug:"sachil-kumar",fullName:"Sachil Kumar"},{id:"345319",title:"MSc.",name:"Geetika",middleName:null,surname:"Saxena",slug:"geetika-saxena",fullName:"Geetika Saxena"},{id:"345320",title:"MSc.",name:"Archana",middleName:null,surname:"Gautam",slug:"archana-gautam",fullName:"Archana Gautam"}]},{id:"19161",title:"Diagnostic of Drowning in Forensic Medicine",slug:"diagnostic-of-drowning-in-forensic-medicine",totalDownloads:8217,totalCrossrefCites:9,totalDimensionsCites:18,abstract:null,book:{id:"243",slug:"forensic-medicine-from-old-problems-to-new-challenges",title:"Forensic Medicine",fullTitle:"Forensic Medicine - From Old Problems to New Challenges"},signatures:"Audrey Farrugia and Bertrand Ludes",authors:[{id:"34146",title:"Dr.",name:"Audrey",middleName:null,surname:"Farrugia",slug:"audrey-farrugia",fullName:"Audrey Farrugia"},{id:"49284",title:"Dr.",name:"Bertrand",middleName:null,surname:"Ludes",slug:"bertrand-ludes",fullName:"Bertrand Ludes"}]}],onlineFirstChaptersFilter:{topicId:"1019",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. 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Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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