Epithelial-mesenchymal transition (EMT) plays a key role in cancer metastasis. This process is a complex, multi-functional, and tightly regulated developmental program. EMT has been extensively investigated, but the molecular regulation of its signaling pathway is highly complex. In this study, the different elements of EMT cascades that could be targeted were determined. Difficulties in translating the preclinical findings in routine clinic were also distinguished. Future research will provide insights into the activation and regulation of various EMT programs in different tumor types and at distinct stages of tumor development. These results will likely facilitate the development of early detection strategies and improve the therapeutic targeting of malignant solid tumors.
Part of the book: Tumor Metastasis
Lung cancer treatment remains difficult because of multidrug resistance and adverse effects, and natural product molecules show powerful activity in lung cancer with few side effects. The molecular targets and efficacy of natural product molecules remain unclear. We described the molecular regulation of natural product molecules with antitumor activities, the antilung cancer activities and the clinical trials for lung cancer treatment of natural product molecules. The results support the updated systemic information on the use of natural product molecules to prevent cancer progression and their constituents for lung cancer treatment.
Part of the book: Prevention, Diagnosis, and Treatment of Lung Cancer