List of major diseases associated with vitamin D deficiency in Saudi Arabia.
\r\n\tThere are a variety of approaches to reversing biodiversity loss, ranging from economic, to ecological and ethical. The utilitarian approach to conservation, bolstered by the concept of ecosystem services, can be utilized to improve the conservation case by supplementing the burgeoning biodiversity rhetoric. To address this issue, a pluralistic approach to biodiversity is required for conservation and sustainability.
",isbn:"978-1-80356-339-8",printIsbn:"978-1-80356-338-1",pdfIsbn:"978-1-80356-340-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"ab014f8ed1669757335225786833e9a9",bookSignature:"Dr. Gopal Shukla, Dr. Jahangeer Bhat and Dr. Sumit Chakravarty",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11460.jpg",keywords:"Ecosystem Services, Intrinsic Value, Global Trends in Biodiversity Loss, Convention on Biological Diversity, Utilitarian Value, Biodiversity Conservation, Perception, In Situ and Ex Situ Conservation, Nature Conservation, Sustainable Development Goals, Drivers of Degradation, Prioritizing Biodiversity",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 17th 2022",dateEndSecondStepPublish:"April 22nd 2022",dateEndThirdStepPublish:"June 21st 2022",dateEndFourthStepPublish:"September 9th 2022",dateEndFifthStepPublish:"November 8th 2022",remainingDaysToSecondStep:"a month",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Gopal Shukla, prior to becoming an assistant professor, has worked under NAIP (National Agricultural Innovation Project), NICRA ( National Innovations on Climate Resilient Agriculture), and SERB (Science and Engineering Research Board) projects. 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Nevertheless, the influence of vitamin D is more than just mineral and skeletal homeostasis. The existence of vitamin D receptors (VDR) in several tissues and organs implies that vitamin D physiology encompasses beyond bone maintenance [1]. Furthermore, the enzyme responsible for the conversion of 25[OH]D to its biologically active form [Vitamin D (1, 25[OH]2D)] has been recognized in several other tissues aside from kidneys with evidence growing that extra renal synthesis of 1, 23[OH]2D may be just as important in regulating the cell growth of cellular differentiation via paracrine or autocrine regulatory mechanisms [2–4]. Figure 1 shows the schematic overview of vitamin D metabolism that starts in the liver, where vitamin D is hydroxylated to 25(OH)D, the main circulating vitamin D metabolite used for vitamin D deficiency diagnosis [5]. Further hydroxylation of 25(OH)D to 1, 25(OH)D is catalyzed by 1α-hydroxylase which is expressed in multiple tissues and binds to vitamin D receptors that in turn regulates various genes [5].
\nVitamin D metabolism overview (figure reprinted from Pilz et al. [
Vitamin D’s etymology was obtained in the early part of the twentieth century after the discovery of the antirachitic effect of cod liver oil [6]. Then, the unidentified vitamin in cod liver oil was labeled as “D,” similar to vitamins A, B, and C, which have been already identified. Synthesis of vitamin D from the skin provides most of the vitamin to the body (80–100%) and with adequate sunlight exposure, dietary vitamin may be unnecessary. However, time spent outdoors or the amount of incidental sun exposure on a regular basis, latitude, age, and skin color influence the cutaneous production of vitamin D and therefore affect vitamin D status. Foods rich in vitamin D include high-fat content fish (sardines, salmon, herring, and mackerel) that are meager and costly, since the study site is situated far from the coast, meat and egg, and fortified milk, juice and margarine. Even in some countries where certain foods are fortified with vitamin D, dietary intake of vitamin D is usually insufficient to maintain adequate levels of 25-hydroxyvitamin D [7]. Currently, there are three treatment modalities for vitamin D deficiency: sunlight, artificial ultraviolet B (UVB) radiation, and vitamin D supplementation [7]. Ideal 25-hydroxyvitamin D [25(OH)D] levels continue to be debated in scientific circles and the definition of vitamin D deficiency changes almost yearly and ranges become higher than previously thought. As of this writing, the most commonly accepted definition of vitamin D deficiency is the one endorsed by the US Endocrine Society, that is, circulating serum 25(OH)D levels <50 nmol/l (<20 ng/ml) [8].
\nGlobally, vitamin D deficiency is widespread and is considered as an epidemic [9]. In a systematic literature review done by Hilger et al. in 44 countries involving more than 168,000 participants, 37.3% of the studies reported mean values <50 nmol/l, with the highest values reported in. Furthermore, it was only in the Asia/Pacific and Middle East/African regions where they observed age-related differences [10]. The recent study of Haq et al. also measured vitamin D deficiency prevalence in a single laboratory in United Arab Emirates, and this time involved 60,979 patients coming from 136 countries and revealed severe vitamin deficiency (25(OH)D <25 nmol/l) in 23% of the subjects tested and another 37% falling under mild deficiency (25(OH)D <50 nmol). This study is unique among other large-scale epidemiologic studies since it involved several nationalities in one setting and using only one laboratory, minimizing the need to adjust for known vitamin D cofactors such as geographical location and variability between measurements [11]. The Middle East and North African (MENA) region in general has a very high prevalence of vitamin D deficiency and is most prominent in women of varying ages [12]. The Kingdom of Saudi Arabia (KSA), being part of the MENA region, is not spared from vitamin D deficiency, despite the sunlight-rich environment.
\nSedrani [12] was the first to document vitamin D deficiency in KSA, and this was observed among apparently healthy student males of King Saud University, Riyadh, KSA. Since then and in the same year [12], other studies using different healthy subpopulations have emerged, mostly women of child-bearing age [13–16]. In all studies, henceforth, vitamin D deficiency ranged from one out of five Saudis, to almost 100%. Consequently, at this time, rapid industrialization was taking place at KSA. Environmental risk factors in lifestyle such as daytime sleep and night time activities, work environments, which are sedentary and extreme weather conditions, may have been contributory [17]. Certain groups, such as the elderly, dark skinned, and/or veiled women and their children, are at particular risk of hypovitaminosis D [7, 18]. But more importantly, urbanization and tremendous socioeconomic growth has resulted in profound changes in the way of life during the last three decades, resulting in an increased and sustained incidence of obesity and type-2 diabetes mellitus [19], diseases known to elicit depressed circulating levels of vitamin D. As time passed, and with advancing technology and faster dissemination of information, epidemiologic studies on vitamin D deficiency across KSA has emerged. Through the initiatives of HRM, King Abdullah bin Abdulaziz Al-Saud, and the thrust for a knowledge-based economy, the research industry in KSA exponentially flourished and with it, several large scale studies paved way for exposing the worsening vitamin D deficiency in KSA [20, 21]. Furthermore, debilitating diseases associated with vitamin D deficiency have started to emerge and become more prominent, including osteoporosis [22], type-2 diabetes mellitus [23, 24], and systemic lupus erythematosus [25] to name a few.
\nVitamin D deficiency has been consistently associated with hypertension, diabetes mellitus, cardiovascular disease, stroke, multiple sclerosis, inflammatory bowel disease, osteoporosis, periodontal disease, macular degeneration, mental illness, propensity to fall, and chronic pain and various cancers [26]. Most tissues have not only vitamin D receptors, but also hydroxylase enzyme that is required to convert 25(OH)D to the active form, 1α,25-dihydroxyvitamin D3 [27]. Therefore, vitamin D can affect tissues that are not involved in calcium homeostasis and bone metabolism. Almost all tissues in the body possess vitamin D receptors including brain, heart skeletal muscle, smooth muscle cells, pancreas, activated T and B lymphocytes, and monocytes [28].
\nThe major diseases associated with vitamin D deficiency in KSA are listed in Table 1. Among these, the most widely documented include vitamin D deficiency rickets among Saudi children and type-1 diabetes mellitus and osteoporosis in adults. It is expected that with the increasing elderly Saudi population, the prevalence of chronic noncommunicable diseases, including osteoporosis in KSA, will increase if not remain steady, and uncorrected vitamin D deficiency being a risk factor for these diseases will play a major role in the progression of these diseases. It is worth to note that among these diseases, the emergence of increasing incidence of fibromyalgia or chronic muscle pain is mostly experienced by Saudi women, which showed significant improvement after treatment of high-dose vitamin D [52, 53], and reversal of metabolic syndrome manifestations among Saudi adults by mere increased sun exposure [54]. Several intervention studies are further required for the rest of the nonskeletal diseases where vitamin D is involved to determine whether vitamin D status correction will provide major beneficial effect.
\n[29] | \n|
[30, 31] | \n|
[32, 33] | \n|
[21, 23, 24, 34, 35] | \n|
[20–22, 36–44] | \n|
[45, 46] | \n|
[25] | \n|
[47–49] | \n|
[39, 50, 51] | \n
List of major diseases associated with vitamin D deficiency in Saudi Arabia.
The two commonly available forms of vitamin D supplements are ergocalciferol (vitamin D2) and cholecaleiferol (vitamin D3). Some, but not all, studies suggest that vitamin D3 increase serum 25[OH]D more efficiently than does vitamin D2 [55–57]. The best indicator of vitamin D status is 25-hydroxyvitamin D because it is the major circulating form of vitamin D; it reflects cutaneous and dietary intake [58]. A nonfasting sample taken at any time of the day is suitable for the measurement of 25-hydroxyvitamin D status. Although calcitriol 1,25 dihydroxycholecalciferol is the active form of vitamin D, it is not an appropriate indicator of vitamin D status. It is usually normal or even elevated in patients with vitamin D deficiency. Although reliable and consistent evaluation of serum 25[OH]D level remains an issue, reliable laboratories currently exist, and efforts are in progress to improve and standardize assays to enhance accuracy and reproducibility at other laboratories.
\nAdults with 25 OHD 50–75 nmol/L require treatment with 800 to 1000 IU of vitamin D3 daily. This intake was hypothesized to increase the vitamin D status to 7 nmol/L over a three-month period, but still, many individuals might require higher doses. In malabsorptive states, oral dosing and treatment duration depend on the individual patient’s vitamin D absorptive capacity. Mega doses of vitamin D (10,000 to 50,000 IU daily) may be essential for postgastrectomy patients or patients with malabsorption. In cases where such patients remain deficient/insufficient despite such doses, they should be treated with hydroxylated vitamin D metabolites (since they are more readily absorbed) or with sun or sun camp exposure. All patients should maintain a daily calcium intake of at least 1000 mg (for ages 31 to 50 years) to 1200 mg (>51 years old) per day [59].
\nSince vitamin D is a fat-soluble vitamin, there are concerns about toxicity from excessive supplementation. Widespread fortification of food and drink from the 1930s to 1950s in the United States and Europe led to reported cases of toxicity. Increased levels of vitamin also raise calcium levels. Most of the symptoms of vitamin D toxicity are secondary to hypercalcemia. Early symptoms include, but are not limited to, gastrointestinal disorders like anorexia, diarrhea, constipation, nausea, and vomiting. Other reported symptoms include bone pain, drowsiness, continuous headaches, irregular heartbeat, loss of appetite, muscle, and joint pain are other symptoms that are likely to appear within a few days or weeks; frequent urination, especially at night, excessive thirst, weakness, nervousness and itching, and kidney stones [60].
\nThis chapter provides a glimpse on the essential knowledge about this micronutrient vitamin D, as it is one of the most clinically important nutritional deficiencies. It is by no means comprehensive but nevertheless equips the reader with vital information on vitamin D with special attention in the Middle East and Saudi Arabia.
\nThe author declares no conflict of interest.
\nBiological adaptation to the sun light has advanced over billions of years. Historically, 200 years ago was the discovery of electric both lighting and power for the first time. In spite of the fact that this invention has been of incredible advantage for humankind, it has completely changed work environments, social, and home.
Light at night gave us the in-dependency from the normal daylight for living and to work longer hours and with a more income. The utilize of electric has not only been limited to night time but has also moreover made it conceivable to live and work independently of daylight during the day.
The contrast between artificial lighting and the sunlight. Sunlight is strong at all twelve visible wave-lengths which cresting within the yellow region. However, artificial light has either extreme characteristic wave-length crests like fluorescent or shows a monotonic increment in irradiance as wave-length protracts like radiant.
Night light sources have the ability to light the evening sky brighter than the new moon. Many voices has started to complain about increase the night light and its health effects. In spite of the fact that the global increasing of breast cancer rates is observed in industrialized countries [1, 2].
Over the past decade the speculation that night light inhibit melatonin production may act as a risk of breast cancer. This may due to that exposure to night light disturbs endogenous melatonin secretion. There is presently evidence that these changes have had great effect on health globally. Exposing to light after sunset is overriding the natural light–dark exposure pattern [3, 4, 5].
Whereas broad light night is needed for cutting edge society and business. There are a few regulations to overcome this modern phenomena. Therefore, it is crucial to appraise the adverse health effects of night light on the human health so that effective intercession can be formed to reduce harmful effects of exposure to night light.
Night light is a human-made light which can delivered from lighting that radiates from electric lamps. The increase of night light in cities has extended human human activity into the dark hours. It has been assessed that more than 80% of the world population is beneath light-polluted atmosphere that have an excessive artificial light [1, 6, 7].
Shifting to the light emitting diode (LED) technology in cities world wide has consequence in increasing in artificial light at night and especially blue-light because the use of white LED as the brand-new light standard in urban and rural areas [8]. Its well known that shift work affect circadian disruption is likely a carcinogenic risk factor to humans [9]. Most studies focused on breast cancer. However, there are studies focused on prostate cancer and night and showed that light night likely to increase risks for prostate cancer [10, 11, 12].
The possible explanation is that the night light inhibit the melatonin production which is a hormone usually produced at the dark, changes of sleep activities, and deregulation of circadian genes [13, 14]. Melatonin affects on estrogen-receptor positive human breast cancer cells [15, 16, 17].
In addition, several studies about day and night shift workers showed an interruption in both peak and lower melatonin levels in their urine compared to day workers. Furthermore, individuals reading using devices that produced blue light such as e-Book, surfing internet with their smart phones before going to bed compared with those who is reading a printed book will take longer to sleep [18].
Genetic background plays a role in changes in wake and sleep time [19]. For instance, a study showed that the lowest melatonin levels was reported among night-shift workers with the morning preference chronotype [i.e. The chronotype of a person is the individual’s ability to sleep over a 24-hour cycle at a given time]. Other factors that may contributed are sex, age, living indoors, type of personality, nighttime illumination may also be related to chronotype [20].
The main achievement of the past century can be called artificial light. Nevertheless, while artificial lighting is extremely advantageous for modern society. It also poses a major drawbacks to human health and the ecological system of the environment in the form of pollution. It is possible to clearly describe light pollution as unnecessary and misdirected artificial lighting [21]. Light pollution defined as a situation where improper use of night light may hinder with people’s comfort and health [22]. Other than the radical issue of sky glow caused by artificial lighting [23], a variety of known ecological problems are also caused by light pollution. Health problems in humans caused by exposure to night light are the most urgent among the known consequences. Via the eye, light is introduced to the human body. While the majority of the light mediates other biological processes in humans, such as light and dark cycles. The First Atlas of Artificial Night Sky Brightness, reported that about 99% of European and American populations, and about one-fifth of world is under polluted skies [24].
Increase evening exposure to indoor short-wavelength light from LED lights, television, tablete, and smart-phons all these consider to disruptive to circadian function. Electricity system has been improved in the last century due to that the electricity became very cheap [25]. Moreover, artificial light today increased by the wide use of solar panels. This make the night light available in the remote areas. Thus, population exposure to night light in both indoors and out-doors has increased substantially [26]. Unlike the regular light which had fixed and known emission spectra.
The outdoor light is considered the modern world work and lives in. However, most of the people live now in dim light all the day without exploration to the sun light and undimmed light at night. Outdoor artificial lights includes lighting of: streets, advertising, architectural, security, domestic, vehicles, highways, railways, residential and commercial buildings, industries, shopping centers and sport facilities [27].
Light at night emitted from the above sources, is captured by the satellites through the sensors, circling around the Earth and transferral the captured information into the Defence Meteorological Satellite Program’s database. This database incorporate yearly data after excluding moon and sun light, and other sources of light like fires and lightning. These images capture a small portion of the light arise from the earth’s surface light, they symbolize the levels of night light at the ground level.
Outdoor light at night is considered as a permeant environmental threat by stressing the environment and human health [3, 28, 29]. Theories speculate that extreme exposure of night light is contributing to several health problems by interrupt the circadian rhythm [30].
The dark-and-light cycle provides the basic basis for life on our earth. Human adjustment to the solar cycle has consequence in fundamental molecular and genetic endogenous processes that correspond with an 24-hour period. The circadian genetic clock mechanism is closely involved in many cellular and organs function. While near 24-hours rhythms are produced spontaneously by the circadian system, human master clock must be readjust daily by the light–dark cycle to ensure proper temporal synchronization with the environment.
This everyday entertainment is mainly accomplished in humans by novel photo-receptors that project straight to the site of the circadian clock. The cycle production of a light-sensitive endogenous rhythm probably developed to permit for precise 24-hour control of activities and rest, and also to adapt to seasonal changes in night-length changes, while retaining the benefits of the underlying physiology that anticipates day and night.
Light is the most important trigger for human circadian rhythms to be controlled and is the key environmental time signal for the circadian clock. Light also triggers addition neuro-endocrine and neuro-behavioral responses, including restraint of melatonin production, directly alerting the brain, and improving alertness. The most popular biomarkers studied of the human physiological consequence to dark–light is melatonin. Melatonin is correlate with darkness and is produced at night only, irrespective of whether human is day or night active.
The synthesis and timing of the output melatonin includes a suprachiasmatic nucleus (SCN) afferent signal. Operation of this pathway, which happen in patients with damage of upper cervical spinal, wholly get rid of melatonin production. Some other circadian rhythms not rely on this pathway such as cortisol, body temperature, and sleep–wake cycles.
Increased in tumor development is related to light at night exposure in human [7, 10, 31, 32]. Several studies showed an increased incidence of breast cancer among those living in a heavy artificially lighted areas, due to the effects to circadian and thus suppression of melatonin. Animal study showed a higher tumor and more malignant tumors in female mice exposed to artificial light at night [33].
Three decades ago, a research showed that there was a greater risk of developing breast cancer in women with a history of night shift work. These results contributed to the consideration of light at night is a characteristics of developed nations [34].
Epidemiological studies are a vital component part of the evidence base needed to determine night-time light exposure increase cancer risk. However, these studies are observational studies and cannot provide the mechanism.
Most animal experimental studies showed an accelerate onset of development of mammary tumors followed by continuous bright light at night compared to control animals maintained 12 hours of dark and 12 hours of light.
A dose-dependent suppression of melatonin levels is a consequence from exposure to bright, fluorescent night light. Exposure to the dimmest light intensity at night decreased the peak of circulating melatonin and thus enhancement of tumor growth rates and metabolic activity of linoleic acid.
A study showed that nocturnal melatonin inhibit the growth of both estrogen receptor negative and positive (ER- & ER+). The linoleic acid and poly-unsaturated fatty acid are essential for the alteration of (ER-) tumors. Therefore, and it can be used as a biomarker of cellular growth [35].
In rat hepatoma models, exposure to night light induce tumor growth has been replicated. The opposite is also true, the progressive restoration of circulating melatonin by decreasing exposure to night light is followed by a pronounce decrease in tumor growth.
Its worth mentioning that the growth of xenografts perfused with blood sample collected in the 12-hours dark time was markedly reduced. In addition, the addition of melatonin receptor antagonist blood obtained during darkness eliminated the blood’s ability to suppress perfused tumor growth and metabolic activity.
Moreover, the addition of a melatonin receptor antagonist to the blood obtained during dark time eliminated the ability to suppress perfused tumors growth and metabolic activity. There is also Some evidence that circadian disruption by chronic phase advancement may increase cancer growth in laboratory animals.
Melatonin exhibits anti-proliferative and antioxidant properties modulates both cellular and humoral responses and control epigenetic responses and play a role in the apoptosis of cancer cells and in inhibition of tumor angiogenesis [36, 37, 38, 39, 40].
Experimental evidence from animal studies have linked circadian rhythm disruption and circulating melatonin concentrations to disease progression. However, there is indirect human data and it focused on epidemiological research. These epidemiological research, however, have strengths and limitations, particularly in exposure evaluation and suitable comparison groups. Breast cancer has received the most research has been conducted on breast cancer. The idea was first articulated that the increase of night light may connected to high risk of breast cancer in the developed nations. Thus rising incidence and mortality rate in the developed nations.
Potential mechanisms involve suppression of melatonin and circadian gene activity. This hypothesis would predict that non-day shift work would increase the risk, blind women would be at lower risk, risk would be inversely correlated with recorded sleep length, and the amount of nighttime light in the population would co-distribute with the incidence of breast cancer.
Based on non-day shift occupations studies and breast cancer, it was concluded that shift work involving circadian disturbance is likely to be carcinogenic to humans. Several studies supporting this findings and the WHO has defined shift work as a potential carcinogen due to the chronobiological disturbance [9, 41].
Numerous research about the relationship between breast cancer and light night have been reported mixed findings [42, 43, 44, 45]. Two studies found no association between night work shift and breast cancer [44, 45]. A significant increased risk was found a case control study in Norwegian people with a history of regularly working five nights [42, 43, 46].
Another study showed that a lower risk of breast cancer was associated with increased urinary excretion of melatonin [47]. Non-shift staff with a regular sleep and wake cycle often experience exposure to light at night got disruption of circadian rhythms [48].
After bedtime lights out, it is not yet clear if the ambient background light could affect the circadian system from weak sources in the bedroom or outside light. A brief exposure at these levels does not have a noticeable effect in a laboratory setting, but long-term chronic exposure may.
Four studies have identified an association with a risk of breast cancer of any components of night light level in the bedroom [49, 50, 51]. The elevated risk estimate was statistically significant in two of them [50, 51].
In addition to the limitation of recall error, there is also the potentially important limitation of recall bias as a case–control design. There is a possibility that even a very low of light night exposure may have an effect over a long period of time is significant. Few people in the western world sleep in a complete darkness. The circadian cycle can be disrupted by repeated awakenings with low light exposure in the bedroom but any associated health effects are unknown [52].
The most common cancer among women is breast cancer [53]. Breast cancer incidence rates is increasing rapidly worldwide. The breast cancer incidence increasing rapidly in Western nations such as: Europe, North America, Canada, Australia and New Zeland.
Excessive exposure to night light may raise the risk of breast cancer and there are several mechanisms. The retrieval of non-image-forming photo-receptors in the retina is transferred to the pineal gland as neural information where it suppressing the melatonin secretion. Then changing in the affinity of the estrogen receptor and an increased susceptibility to hormone-dependent cancers like breast cancer [26, 54].
The other possible mechanism is that human can suffer from circadian rhythms disruption by engaging in night time activities which activated by night light contributing to increased susceptibility to breast cancer [26, 55].
According to the third possible mechanism, light at night can function as a general stressor and endocrine disruptor, this is another possible mechanism, particularly when changes in night light intensity are suddenly and unexpected [26, 56]. It was also proposed that melatonin is a mediator between the epigenome and environment [28, 57].
A study found that women exposed to extensive night light are vulnerable to a 12% rise in breast cancer risk. The areas also with the highest night light had a higher rate of occurrence of breast cancer compared to the areas with the darkest environments [31].
In a global study showed that Artificial light at night is significantly correlated for breast cancer. Immediate practical steps should be taken to ban artificial lighting at night in the major cities around the world and also in homes as well [10].
A Nurses’ Health Study reported a small increased breast cancer risk among pre-menopausal women associated with exposure to residential outdoor light at night [30].
A study concluded in Georgia showed that there is a positive associations between breast cancer risk and exposure to night light. This is consistency with the previous research which showed that there is a biological associations between night light exposure to and breast cancer risk. Studies have indicated that disruption of circadian cycle may result in breast tissue carcinogenic. About 30 to 50% higher risk of breast cancer in developed countries with the highest versus lowest light night levels [31, 58].
Blue light exposure before sleeping has been shown to inhibit the development of nocturnal melatonin, which may be associated with an increased risk of breast cancers [13, 59, 60].
All documented reported an environmental impacts of artificial night light, like melatonin production are due to the spectrum of the light [61]. These physiological changes may influence the circadian cycle, sleep timing, control of blood pressure, seasonal reproduction and the role of melatonin as an antioxidant with implications for the prevalence of some certain cancers [15, 62].
The results were not related to a specification lighting technology, but to artificial night light. Studies showed an association between patterns of night light and the incidence of breast cancer and obesity [10, 31, 58, 63].
Blask and colleagues famously showed that a key factor in the connection is melatonin, a hormone produced in nighttime darkness that promotes sleep [64]. They found that when the tumors were perfused with melatonin rich human blood collected during the night, the development of cancer slowed down.
Some studies have concentrated on the CLOCK gene. Stevens and his colleagues found that healthy women displayed lower CLOCK gene expression than women with breast cancer. Switching on or off of genes as a result of artificial light at night may play an important role [65].
Melatonin was first discovered in 1917, indicating that an extract of the bovine pineal gland given to frogs whitened their seed coat (McCord and Allen 1917). Melatonin is a pleiotropic neuro-hormone produced through the darkish section of the 24 hours cycle and secreted by the endocrine gland called pineal gland. Even when the period of light is short with low intensity, melatonin secretion remains to be inhibited by light [37, 64, 66].
About 40 years later chemical extracted from the pineal gland identify and called it melatonin [67]. Since its discovery, melatonin existence has been noted in all studied organisms, ranging from single-cellars to all plants and animals [68].
Various central and peripheral tissues, including the heart and arteries, breast, lung, small intestine, liver, kidney, adrenal gland, ovaries, gallbladder, prostate, and skin. Melatonin also serves as an anti-inflammatory and antioxidant that functions as a free radical scavenger during inflammations and injuries. The rhythmic release of melatonin from the pineal gland helps organize circadian rhythms and neuroendocrine processes by activating pairs of MT1 and MT2 G-protein receptors. Melatonin triggers fatigue, sleepiness and a diminution of sleep latency [69].
Furthermore, it has been demonstrated that inhibition of melatonin in humans by light depends on wavelength, with illumination of shorter wavelengths which is greener and more blue, being more effective at suppressing melatonin than yellow–redness of longer wavelengths [62]. Overall, exposure to artificial light by disrupting melatonin production, interferes with our temporal organization, possibly leading to cell dysfunction, and promoting the abnormal proliferation of altered cells.
Several research showed that melatonin plays a significant role in numerous functions of living human and can be an antioxidant and anti-oncogenic agent [70, 71].
The production and secretion of pineal melatonin increases after dusk and, in humans, it resumes between 2 am and 4 am, while after this period, its production slows down and stops about 3 h after sunrise [72]. As we additionally know today, light disturb melatonin creation and secretion.
The immune system exhibits rhythms and disturbance daily. Association between serum melatonin and phagocyte activity was documented. The presence of lymphocytes melatonin receptors is another significant point for connection between melatonin, and changes in the immune system [73].
Among its different capacities, melatonin moves the dark sign to all body cells and tissues keeping up the first essential capacity of a photoreceptor creation, recognizing photophase and scotophase, while the relations between them is likewise moved by melatonin subsequently flagging irregularity to the cells and tissues.
In young people melatonin is known to stifle the development and activation of the reproductive system, thus delaying sexual maturity. Melatonin is also known as a direct anti-oncogenic agent In regards to breast cancer, several mechanisms are suggested for its role, including. Melatonin is also known as anti-oncogeneic agent for breast cancer and prostate cancer. Concerning breast cancer, modification of estrogen receptors is the key that melatonin play its role.
Clinical studies showed a relationship between melatonin levels and metastatic of breast cancer, where a decrease in melatonin were noted in breast cancer patients, when compared with healthy ladies, bigger tumors also related with lower melatonin levels.
Melatonin synthesis and release happens in response to darkness and inhibited by light. Melatonin peak levels normally occur during sleep after midnight. These levels decrease and become minimal when we are exposed to day light.
A call for additional investigation of the connection between night light and shift workers and cancer that might be melatonin depended. This call is as yet applicable for shift workers, urban and rural populations exposed to light at night, electronic gadgets with LED lights become a well known source of light pollution [36].
It has been showed that high melatonin levels at day time result in seasonal affective disorder which is very common in northern America and in northern Europe. This disorder is managed primarily mental doctors, and additionally by chrono-scholars, as a typical solution for Seasonal Affective Disorder is presenting the subjects to short frequency light which stifles melatonin. This demonstrating the significance of timing, the decrease of melatonin secretion at day time is also important for human well-being, while disturbance that may rise out of a deficient amount of light at day time will likewise have negative well-being impacts.
The importance of exposure to natural day light is of great importance for the resetting of melatonin production. The short light wavelength suppresses melatonin production and skin produces vitamin D. Because of the modern life, many individuals around the world are not exposed to natural light as they venture out form home for work before sunshine and come back after sunset. This way of life result in the way that melatonin production isn’t totally smothered, suppressed, while vitamin D production is stifled. As a result of night light exposure, environmental temporal cues are not transferred correctly to the cells for adjusting our temporal organization.
Driven brightening in electronic gadgets encompasses us and goes with us even while sleeping. Therefore, children exposed to such brightening for a long time during the dark period during the time melatonin is to be created under dim conditions. As melatonin levels are not tested consistently, a large portion of people are unconscious of the risks involves.
Several studies suggested the existence of the “immune-pineal” axis. The pineal gland serves as an inflammation mediator to synthesis melatonin, where pro-inflammatory mediators inhibit the production of melatonin while anti-inflammatory mediate potentiate melatonin production [74, 75, 76].
Mechanisms of many diseases can be explaned by understanding the relationship between the pineal gland and immune response. In addition to being a photoperiodic information transducer, the pineal gland is also a constitutive participant in the intrinsic immune response [76].
As a likely mechanism, sleep would possibly affects circulating hormones such as melatonin, cortisol, growth hormone, prolactin and insulin levels, which can be key factors in many disease processes, including breast cancer [77]. Thus, many studies have examined the association between sleep period and breast cancer incidence [78, 79, 80, 81].
Circadian and sleep disruption might also additionally act on molecular, immunologic, cellular, neuroendocrine, and metabolic levels in methods that make contributes to development of breast cancer.
Mammary carcinogenesis stars with mutation of a healthy cell through alterations in immune and cellular processes, including:
Oxidative nuclear DNA damage.
Changes in cellular apoptosis.
Changes in innate immune function.
Mutated cells are capable to survive despite the innate tumor suppressor mechanisms through inactivation of the p53 gene which could reduced apoptosis of aberrant cells [82]. Steroid hormones play an important role in the growth of breast cells, and estrogen considered an oncogenic agent is well known. The availability and timing of melatonin is adversely affected by sleep disturbance and circadian disruption.
Continual inflammation can stimulate genetic instability that can result in cell mutations. Disruptions in sleep and circadian cycle have affect on predispose the organism and metabolic processes to increased adiposity, which increase the risk of breast cancer.
Repeated sleep and circadian cycle have an impact on innate and acquired immune function. Several studies have shown that decreased circulating NK cell numbers and NK cytotoxicity are associated with a single night of sleep deprivation [83, 84].
Sleep disruption may also causes a shift in cytokine creation from Th-1 cytokines to Th-2 cytokines, including IL-10, that may permit tumor cells to escape from immune surveillance and this may increased breast cancer risk [85]. Healthy sleep is associated with pre-myeloid dendritic cells production, which produce IL-12 a cytokine related to the delay of tumor onset [86].
Chronic inflammation is implicated in the oncogenic pathway, and both circadian disruption and sleep disruption were confirmed to have pro-inflammatory effects [87]. Certain lymphocytes are able to produce melatonin and in turn, melatonin has been proven to moderate the function of many immune functions [83].
Repeated disruptions in melatonin synthesis as a consequences of nightly circadian and sleep disruption might also additionally have negative effects on healthy immune functioning [88].
Sleep disruption is associated with increased glucocorticoid production and several studies indicated that short sleep duration and sleep deprivation are both associated with altered cortisol profiles and raised evening cortisol levels [89]. Glucocorticoid input from the adrenal gland has suppressive impacts on the amplitude of circadian cycle within the pituitary gland and hypothalamus [90].
Oxidative stress is known to cause DNA damage and is related with increased risk of breast cancer. On the other hand, antioxidants decrease DNA damage. Oxidative stress-induced DNA damage may be an essential pathway by which sleep disturbance may have effects on breast than circadian disruption [91].
Sleep have antioxidant impacts, giving an opportunity for the body to expel oxidants produced during alertness [92].
Many studies showed that sleep disturbance may increases reactive oxygen species (ROS) [93, 94]. ROS can lead to DNA damage by binding to neighboring molecules with unpaired electrons, causing strand breaks and its formation link between circadian cycle and sleep hardship [95].
Sleep disturbance contribute to oncogenesis through damage cellular, and disrupting the circadian cycle. Oxidative stress play an important role as a mediator of cellular apoptosis [96]; sleep deprivation-induced oxidative stress can permit the mutated cells to elude apoptosis. Circadian cycle also involved in this pathway.
It has been proposed that the circadian cycle formed as a result of counteracting oxidative damage caused by radiation. Melatonin may be a powerful free radical forager that impacts quinine reductases to decrease oxidative damage [97].
Studies showed that animals whose melatonin generation was disrupted by pineal or SCN ablation were prone to increased rates of mammary carcinogenesis. In another study, showed that melatonin suppression is related with increased hyperplastic processes and tumorigenesis in the mammary gland [98, 99, 100].
Several hormones, such as estrogens, progesterone and prolactin influence the etiology of breast cancer. Melatonin has an inhibitory effect on the receptors of estrogen and can counteract the estrogen’s tumor-promoting impact. In addition, melatonin can increase the cell cycle length and avoid progression. These actions oppose the estradiol pathways, which promote cell proliferation and progression of cells [101, 102].
Sleep also impacts hormone levels.
Partial sleep deprivation among healthy women results in increases in Luteinizing Hormone (LH) and estradiol and elevated levels of prolactin levels [103]. Besides, there’s conversely association between sleep hardship with levels of pestradiol. These indicated that regular sleep disturbance and short sleep at night may be related with chitinous elevation of estrogen levels which considered a risk factor of breast cancer. Ladies sleeping more than nine hours decreased the breast cancer risk compared to ladies sleeping seven hours [104].
The natural 24-hour cycle of light and darkness make a difference to preserve exact arrangement of circadian biological cycle, the main activation of the central nervous system and several cellular and biological processes, and pineal gland release of melatonin. All future outdoor lighting must be of energy efficient designs to reduce light pollution. The disturbance of the sleep–wake cycle and melatonin suppression may be due to to more direct health effects of night light. Even low intensity nighttime light has the capability of hinder melatonin release. Melatonin suppresses tumor growth and serves as a circulating anticancer signal. Many epidemiological studies back the theory that night light increases breast cancer risk. The quality and length of sleep and darkness affect several biological processes that are currently under investigation. Further information is required to assess the role of sleep versus the period of darkness on cancer. Due to the nearly present exposure to night light at improper times relative to endogenous circadian cycle, there is an urgent need for multidisciplinary research to address the assocation between night light and cancer.
There is no conflict of interest.
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Nanoparticles are sized between 1 and 100 nm in diameter. Nanoparticles can act against the microbes in multiple ways, and the microbes are less likely to develop resistance against nanoparticles because it requires multiple gene mutations. The large surface-to-volume ratio of nanoparticles, their ability to easily interact with other particles, and several other features make them attractive tools in various fields. Nanoparticles are widely used various fields such as electronics, cosmetics, biomedical, and biotechnology. Nanoparticles can be synthesized by physical methods such as attrition, pyrolysis, and using some wet chemical methods. The physical and chemical methods have various drawbacks such as high cost of production, require high energy input and generation of toxic by-products. To overcome this, several biological methods are employed in the synthesis of nanoparticles. The biological methods are generally cost effective, nontoxic, and ecofriendly. This chapter focuses on the methods involved in algal-synthesized nanoparticles and its applications.",book:{id:"5128",slug:"algae-organisms-for-imminent-biotechnology",title:"Algae",fullTitle:"Algae - Organisms for Imminent Biotechnology"},signatures:"Felix LewisOscar, Sasikumar Vismaya, Manivel Arunkumar,\nNooruddin Thajuddin, Dharumadurai Dhanasekaran and Chari\nNithya",authors:[{id:"183668",title:"Dr.",name:"Nithya",middleName:null,surname:"Chari",slug:"nithya-chari",fullName:"Nithya Chari"}]},{id:"51074",doi:"10.5772/62916",title:"Algae as an Indicator of Water Quality",slug:"algae-as-an-indicator-of-water-quality",totalDownloads:5034,totalCrossrefCites:11,totalDimensionsCites:23,abstract:"The formation of plankton/algae under natural conditions is related to tolerance class (ecological optimum) due to abiotic limiting factors of ecosystem, as well as the biotic interactions among algae. In the ecological niche, the appearance of organisms is affected by anthropogenic and non-anthropogenic environmental factors. Algae composition and temporal variation in abundances are important in determining the trophic level of lakes. Algal communities are sensitive to changes in their habitat, and thus, total biomass of algae and many algae species are used as indicators of water quality. Algae communities give more knowledge on variations in water quality than nutrient or chlorophyll-a values. Water quality is a canonical group of physical, chemical, and biological properties of the given water. Consequently, eutrophication of freshwater is regarded as a water quality which results in the degeneration of the aquatic ecosystem and affects water utilisation. Cyanobacteria has been accepted as a major indicator of eutrophication in freshwater as their blooms are common in waters affected by nutrient concentration. The purpose of this chapter is to assess physical and chemical variables and the role of algal abundance to determine the water quality in the freshwater ecosystems.",book:{id:"5128",slug:"algae-organisms-for-imminent-biotechnology",title:"Algae",fullTitle:"Algae - Organisms for Imminent Biotechnology"},signatures:"Didem Gökçe",authors:[{id:"178260",title:"Associate Prof.",name:"Didem",middleName:null,surname:"Gokce",slug:"didem-gokce",fullName:"Didem Gokce"}]},{id:"50534",doi:"10.5772/63069",title:"Considerations for Photobioreactor Design and Operation for Mass Cultivation of Microalgae",slug:"considerations-for-photobioreactor-design-and-operation-for-mass-cultivation-of-microalgae",totalDownloads:5994,totalCrossrefCites:8,totalDimensionsCites:17,abstract:"Microalgae have great biotechnological potential for production of substances through photosynthesis. Light capture process and electron transportation imply energy losses due to reflection, fluorescence emission, and energy dissipation as heat, giving a maximum theoretical value of 8‐9% for microalgae energy capture efficiency and conversion to biomass. For development of full potential of microalgae the knowledge of the light capture process is required. High yields can only be obtained linking photobioreactor design with biological process taking place inside. In massive microalgae cultures, light gradients are generated and this depends on the biomass concentration, cellular types, cells sizes, and pigment content, and also on geometry, hydrodynamic, and light conditions inside the photobioreactor. In the present chapter we explain the relationship between light energy capture process and photobioreactor design and operation conditions, like turbulence, gas exchange, and nutrient requirements. Finally, the productivity and costs are discussed, and the parameters that determine the economic viability of any microalgae culture.",book:{id:"5128",slug:"algae-organisms-for-imminent-biotechnology",title:"Algae",fullTitle:"Algae - Organisms for Imminent Biotechnology"},signatures:"Juan Cristóbal García Cañedo and Gema Lorena López Lizárraga",authors:[{id:"185868",title:"Dr.",name:"Gema Lorena",middleName:null,surname:"López-Lizárraga",slug:"gema-lorena-lopez-lizarraga",fullName:"Gema Lorena López-Lizárraga"},{id:"293413",title:"Dr.",name:"Juan Cristóbal",middleName:null,surname:"García Cañedo",slug:"juan-cristobal-garcia-canedo",fullName:"Juan Cristóbal García Cañedo"}]},{id:"69201",doi:"10.5772/intechopen.89324",title:"Drying and Quality of Microalgal Powders for Human Alimentation",slug:"drying-and-quality-of-microalgal-powders-for-human-alimentation",totalDownloads:1263,totalCrossrefCites:5,totalDimensionsCites:15,abstract:"The demand for natural foods with high protein content and functional properties is constantly growing in the last years. In this context, microalgae as Spirulina (Arthrospira spp.), Chlorella spp., Haematococcus pluvialis, Dunaliella salina, and others, assume a key role to diversify the offer of nutritious and functional ingredients and supplements. Microalgae are commercialized, mostly, as dried powders to facilitate their use as food ingredients and to allow easy transportation and long-term stability. Microalgal powder quality and storage stability depend mainly on drying method, packaging, and storage conditions. Most of the studies that approach the subject of microalgal drying evaluate the efficiency of the process and suitability for this raw material. However, studies that assess the effect of traditional and innovative drying methods on quality of microalgal powder for human consumption are rare in literature. In this chapter, the state of the art of drying processing technology for microalgae was reviewed, discussing the effect of dehydration on quality and stability of microalgal powders with potential use in human alimentation.",book:{id:"9354",slug:"microalgae-from-physiology-to-application",title:"Microalgae",fullTitle:"Microalgae - From Physiology to Application"},signatures:"Fábio de Farias Neves, Mariana Demarco and Giustino Tribuzi",authors:null},{id:"50671",doi:"10.5772/63272",title:"Challenges and Opportunities in the Present Era of Marine Algal Applications",slug:"challenges-and-opportunities-in-the-present-era-of-marine-algal-applications",totalDownloads:2747,totalCrossrefCites:3,totalDimensionsCites:12,abstract:"Marine algae are of high importance in their natural habitats and even more now in the world of green technology. The sprouting interest of the scientific community and industries in these organisms is driven by the fast-growing world of modern biotechnology. Genomics, transcriptomics, proteomics, metabolomics and their integration collectively termed here as ‘marine algal-omics’ have broadened the research horizon in view of enhancing human’s life by addressing environmental problems and encouraging novelty in the field of pharmaceuticals among so many more. Their use in the human society dates back to 500 B. C. in China and later across the globe; they are still being used for similar purposes and more today. There is a hiking interest in marine algae and their derivatives—from phycoremediation, food supplements, pharmaceuticals to dyes. Marine algae are currently considered as an emerging panacea for the society. They are being studied in a multitude of arenas. The multi-use of marine algae is enticing and promises to be a boon for industrial applications. Yet, most marine algae face challenges that might variably constrain their commercialisation. This chapter gives an overview of marine algae including all the ‘omics’ technologies involved in studying marine algae and it explores their multitude applications. It also draws the various successful industries budded around them and presents some of the challenges and opportunities along with future directions.",book:{id:"5128",slug:"algae-organisms-for-imminent-biotechnology",title:"Algae",fullTitle:"Algae - Organisms for Imminent Biotechnology"},signatures:"Keshini Beetul, Arvind Gopeechund, Deepeeka Kaullysing, Sushma\nMattan-Moorgawa, Daneshwar Puchooa and Ranjeet Bhagooli",authors:[{id:"178209",title:"Ms.",name:"Keshini",middleName:null,surname:"Beetul",slug:"keshini-beetul",fullName:"Keshini Beetul"},{id:"184390",title:"Mr.",name:"Arvind",middleName:null,surname:"Gopeechund",slug:"arvind-gopeechund",fullName:"Arvind Gopeechund"},{id:"184391",title:"Ms.",name:"Deepeeka",middleName:null,surname:"Kaullysing",slug:"deepeeka-kaullysing",fullName:"Deepeeka Kaullysing"},{id:"184392",title:"Mrs.",name:"Sushma",middleName:null,surname:"Mattan-Moorgawa",slug:"sushma-mattan-moorgawa",fullName:"Sushma Mattan-Moorgawa"},{id:"184393",title:"Prof.",name:"Daneshwar",middleName:null,surname:"Puchooa",slug:"daneshwar-puchooa",fullName:"Daneshwar Puchooa"},{id:"184394",title:"Dr.",name:"Ranjeet",middleName:null,surname:"Bhagooli",slug:"ranjeet-bhagooli",fullName:"Ranjeet Bhagooli"}]}],mostDownloadedChaptersLast30Days:[{id:"64156",title:"Cyanobacteria Growth Kinetics",slug:"cyanobacteria-growth-kinetics",totalDownloads:1799,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Harmful cyanobacterial blooms are a global problem for freshwater ecosystems used for drinking water supply and recreational purposes. Cyanobacteria also produce a wide variety of toxic secondary metabolites, called cyanotoxins. High water temperatures have been known to lead to cyanobacterial bloom development in temperate and semiarid regions. Increased temperatures as a result of climate change could therefore favor the growth of cyanobacteria, thus augmenting the risks associated with the blooms. Though temperature is the main factor affecting the growth kinetics of bacteria, the availability of nutrients such as nitrogen and phosphorus also plays a significant role. This chapter studies the growth kinetics of toxin-producing Microcystis aeruginosa and evaluates potential risks to the population in scenarios of climate change and the presence of nutrients. The most suitable control methods for mitigation are also evaluated.",book:{id:"6889",slug:"algae",title:"Algae",fullTitle:"Algae"},signatures:"Leda Giannuzzi",authors:[{id:"252117",title:"Dr.",name:"Leda",middleName:null,surname:"Giannuzzi",slug:"leda-giannuzzi",fullName:"Leda Giannuzzi"}]},{id:"65952",title:"CO2 Capture for Industries by Algae",slug:"co-sub-2-sub-capture-for-industries-by-algae",totalDownloads:2102,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"The increased usage of fossil fuels has led to increase in the concentration of CO2, which is a greenhouse gas responsible for global warming. Algae-based CO2 conversion is a cost-effective option for reducing carbon footprint. In addition, algae-based CO2 mitigation strategy has the potential to obtain valuable products at the end of the process. In the present study, freshwater algal species were isolated and identified for CO2 capture, such as Hydrodictyon, Spirogyra, Oscillatoria, Oedogonium, and Chlorella. The algal strains were screened based on different parameters like fast growth rate, high rate of photosynthesis, strong tolerance to the trace constituents of other gases (gaseous hydrocarbons, NOx, SOx, etc.), high temperature tolerance, and possibility to produce high value products, etc. The study involves integrated methods for utilizing 90–99% CO2 from a natural gas processing industry (GAIL India, Ltd.) as well as 13–15% of CO2 from flue gas of thermal power plants (Chandrapura and Santaldih Thermal Power Station) as carbon nutrient source along with the additional nutritional supplements. A 400-ml and 25-l flat panel photo-bioreactor (PSI Photo-bioreactors) was used for CO2 capture. After CO2 capture, the algal biomass was used to extract value-added products such as amino acid rich feed, algal oil, algal pellets, etc.",book:{id:"6889",slug:"algae",title:"Algae",fullTitle:"Algae"},signatures:"Vetrivel Anguselvi, Reginald Ebhin Masto, Ashis Mukherjee and Pradeep Kumar Singh",authors:[{id:"255851",title:"Dr.",name:"Vetrivel",middleName:null,surname:"Anguselvi",slug:"vetrivel-anguselvi",fullName:"Vetrivel Anguselvi"},{id:"269996",title:"Dr.",name:"R E",middleName:null,surname:"Masto",slug:"r-e-masto",fullName:"R E Masto"},{id:"269997",title:"Dr.",name:"Ashis",middleName:null,surname:"Mukherjee",slug:"ashis-mukherjee",fullName:"Ashis Mukherjee"},{id:"270059",title:"Dr.",name:"P K",middleName:null,surname:"Singh",slug:"p-k-singh",fullName:"P K Singh"}]},{id:"51074",title:"Algae as an Indicator of Water Quality",slug:"algae-as-an-indicator-of-water-quality",totalDownloads:5034,totalCrossrefCites:11,totalDimensionsCites:23,abstract:"The formation of plankton/algae under natural conditions is related to tolerance class (ecological optimum) due to abiotic limiting factors of ecosystem, as well as the biotic interactions among algae. In the ecological niche, the appearance of organisms is affected by anthropogenic and non-anthropogenic environmental factors. Algae composition and temporal variation in abundances are important in determining the trophic level of lakes. Algal communities are sensitive to changes in their habitat, and thus, total biomass of algae and many algae species are used as indicators of water quality. Algae communities give more knowledge on variations in water quality than nutrient or chlorophyll-a values. Water quality is a canonical group of physical, chemical, and biological properties of the given water. Consequently, eutrophication of freshwater is regarded as a water quality which results in the degeneration of the aquatic ecosystem and affects water utilisation. Cyanobacteria has been accepted as a major indicator of eutrophication in freshwater as their blooms are common in waters affected by nutrient concentration. The purpose of this chapter is to assess physical and chemical variables and the role of algal abundance to determine the water quality in the freshwater ecosystems.",book:{id:"5128",slug:"algae-organisms-for-imminent-biotechnology",title:"Algae",fullTitle:"Algae - Organisms for Imminent Biotechnology"},signatures:"Didem Gökçe",authors:[{id:"178260",title:"Associate Prof.",name:"Didem",middleName:null,surname:"Gokce",slug:"didem-gokce",fullName:"Didem Gokce"}]},{id:"64455",title:"Cyanobacteria for PHB Bioplastics Production: A Review",slug:"cyanobacteria-for-phb-bioplastics-production-a-review",totalDownloads:2186,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"Cyanobacteria, or blue-green algae, can be used as host to produce polyhydroxyalkanoates (PHA), which are promising bioplastic raw materials. The most important material thereof is polyhydroxybutyrate (PHB), which can replace the commodity polymer polypropylene (PP) in many applications, yielding a bio-based, biodegradable alternative solution. The advantage from using cyanobacteria to make PHB over the standard fermentation processes, with sugar or other organic (waste) materials as feedstock, is that the sustainability is better (compare first-generation biofuels with the feed vs. fuel debate), with CO2 being the only carbon source and sunlight being the sole energy source. In this review article, the state of the art of cyanobacterial PHB production and its outlook is discussed. Thirty-seven percent of dry cell weight of PHB could be obtained in 2018, which is getting close to up to 78% of PHB dry cell weight in heterotrophic microorganisms in fermentation reactors. A good potential for cyanobacterial PHB is seen throughout the literature.",book:{id:"6889",slug:"algae",title:"Algae",fullTitle:"Algae"},signatures:"Erich Markl, Hannes Grünbichler and Maximilian Lackner",authors:[{id:"251081",title:"Dr.",name:"Maximilian",middleName:null,surname:"Lackner",slug:"maximilian-lackner",fullName:"Maximilian Lackner"},{id:"255232",title:"Prof.",name:"Erich",middleName:null,surname:"Markl",slug:"erich-markl",fullName:"Erich Markl"},{id:"277237",title:"Dr.",name:"Hannes",middleName:null,surname:"Grünbichler",slug:"hannes-grunbichler",fullName:"Hannes Grünbichler"}]},{id:"50544",title:"Algal Nanoparticles: Synthesis and Biotechnological Potentials",slug:"algal-nanoparticles-synthesis-and-biotechnological-potentials",totalDownloads:5784,totalCrossrefCites:17,totalDimensionsCites:67,abstract:"A nanoparticle can be defined as a small object that behaves as a whole unit in terms of its transport and properties. Nanoparticles are sized between 1 and 100 nm in diameter. Nanoparticles can act against the microbes in multiple ways, and the microbes are less likely to develop resistance against nanoparticles because it requires multiple gene mutations. The large surface-to-volume ratio of nanoparticles, their ability to easily interact with other particles, and several other features make them attractive tools in various fields. Nanoparticles are widely used various fields such as electronics, cosmetics, biomedical, and biotechnology. Nanoparticles can be synthesized by physical methods such as attrition, pyrolysis, and using some wet chemical methods. The physical and chemical methods have various drawbacks such as high cost of production, require high energy input and generation of toxic by-products. To overcome this, several biological methods are employed in the synthesis of nanoparticles. The biological methods are generally cost effective, nontoxic, and ecofriendly. This chapter focuses on the methods involved in algal-synthesized nanoparticles and its applications.",book:{id:"5128",slug:"algae-organisms-for-imminent-biotechnology",title:"Algae",fullTitle:"Algae - Organisms for Imminent Biotechnology"},signatures:"Felix LewisOscar, Sasikumar Vismaya, Manivel Arunkumar,\nNooruddin Thajuddin, Dharumadurai Dhanasekaran and Chari\nNithya",authors:[{id:"183668",title:"Dr.",name:"Nithya",middleName:null,surname:"Chari",slug:"nithya-chari",fullName:"Nithya Chari"}]}],onlineFirstChaptersFilter:{topicId:"424",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",isOpenForSubmission:!0,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",isOpenForSubmission:!0,annualVolume:11407,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,annualVolume:11409,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. 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