Emerging and re-emerging virus figure out with the inauguration periods [32, 33].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10785",leadTitle:null,fullTitle:"Suicide",title:"Suicide",subtitle:null,reviewType:"peer-reviewed",abstract:"The occurrence of suicide often startles those who knew the involved individual. The public often cannot believe that the person who committed suicide could have engaged in such a seemingly irrational and extreme act. Similarly, health agencies often find themselves at a loss as to what strategies or policies might be employed to stem the seemingly constant flow of suicide. This book carefully addresses sociological, psychological, and physiological factors that contribute to suicide. It also presents strategies that might be employed to reduce suicide by way of public policies, psychotherapeutic strategies, and neurophysiological interventions.",isbn:"978-1-83969-726-5",printIsbn:"978-1-83969-725-8",pdfIsbn:"978-1-83969-727-2",doi:"10.5772/intechopen.94810",price:100,priceEur:109,priceUsd:129,slug:"suicide",numberOfPages:86,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"f8ad2d5c55e4551a2e1046369cae627f",bookSignature:"Robert W. Motta",publishedDate:"November 24th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10785.jpg",numberOfDownloads:921,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:2,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:3,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 23rd 2021",dateEndSecondStepPublish:"April 20th 2021",dateEndThirdStepPublish:"June 19th 2021",dateEndFourthStepPublish:"September 7th 2021",dateEndFifthStepPublish:"November 6th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"262071",title:"Prof.",name:"Robert W.",middleName:null,surname:"Motta",slug:"robert-w.-motta",fullName:"Robert W. Motta",profilePictureURL:"https://mts.intechopen.com/storage/users/262071/images/system/262071.jpeg",biography:"Robert W. Motta, Ph.D., ABPP, is Professor of Psychology and director of the Child and Family Trauma Institute at Hofstra University, New York. He formerly served as the chair of the Psychology Department at the same university and is the founder of Hofstra’s nationally accredited PsyD Doctoral Program. He has published more than 100 scientific papers and book chapters and has written two books: Alternative Therapies for PTSD: The Science of Mind-Body Treatments published by the American Psychological Association and Altered: A Trauma and PTSD Casebook. Dr. Motta is board certified in Cognitive-Behavioral Psychotherapy and Behavior Therapy. He is a former president of the School Division of the New York Psychological Association, is licensed as a clinical psychologist, and certified as a school psychologist.",institutionString:"Hofstra University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Hofstra University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"281",title:"Sociology",slug:"sociology"}],chapters:[{id:"77988",title:"Dalit Suicide an Emerging Social Problem in India",doi:"10.5772/intechopen.99320",slug:"dalit-suicide-an-emerging-social-problem-in-india",totalDownloads:194,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"There are various kinds of discrimination is prevailing in Indian Society. India is practising discrimination against the lower caste for many centuries. But in contemporary Indian Society, caste-based discrimination is becoming a matter of grave concern for committing suicide. Caste-based discrimination is surviving in Indian society. In many cases of caste discrimination, Dalits were persecuted by the upper caste of Indian society for demanding education, employment, and equal social status. Every year several Dalits were committing suicide due to atrocities and discrimination. The present study will understand the nature of suicide among Dalits due to social discrimination and explores the factors affecting Dalit suicide. The data on suicide have been collected from 2011 to 2021 through various newspapers, magazines, journals and articles.",signatures:"Avanish Bhai Patel and Sumant Kumar",downloadPdfUrl:"/chapter/pdf-download/77988",previewPdfUrl:"/chapter/pdf-preview/77988",authors:[{id:"308238",title:"Dr.",name:"Avanish Bhai",surname:"Patel",slug:"avanish-bhai-patel",fullName:"Avanish Bhai Patel"},{id:"357222",title:"Dr.",name:"Sumant",surname:"Kumar",slug:"sumant-kumar",fullName:"Sumant Kumar"}],corrections:null},{id:"77921",title:"Suicide: A Public Health Problem in Brazil",doi:"10.5772/intechopen.99071",slug:"suicide-a-public-health-problem-in-brazil",totalDownloads:206,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This text focuses on the situation of suicide in Brazil, defines and quantifies information, and presents a description of the main risk factors, as well as a reflection on the phenomenon and the possibilities for prevention. Fatal suicide is a serious public health problem. In 2012, 172 member states of the World Health Organization registered 804,000 self-inflicted deaths, representing an annual rate of 11.4/100,000, of which 15/100,000 men and 8.0/100,000 women. Consummate suicide rates are unevenly distributed globally, within countries, according to sex and according to age groups. The mortality rate is highest in Asia (17.7/100 thousand inhabitants), followed in Europe (12/100 thousand inhabitants). The Americas have a mortality rate of 7.3/100 thousand inhabitants (WHO, 2014). In Brazil, with an unevenly distributions between the regions, gender and ages, the total rate is 4.5/100,000. In the country and everywhere, risk factors are classified as medical, psychiatric and psychological, micro social, social and environmental. The history of the occurrence of suicides shows that it is possible to prevent them and to reduce the incidence rates. This requires investment in local diagnostics and multidisciplinary action. Given the delicacy of the problem and the taboos that surround it, the protection network for people at risk for suicide needs to be constantly in the process of training and taking action. As national and international surveys show, at least two-thirds of the individuals who tried or committed suicide had somehow communicated to friends, family, acquaintances or health professionals their intention to kill themselves.",signatures:"Maria Cecília de Souza Minayo and Camila Alves Bahia",downloadPdfUrl:"/chapter/pdf-download/77921",previewPdfUrl:"/chapter/pdf-preview/77921",authors:[{id:"198978",title:"Ph.D.",name:"Maria Cecília",surname:"De Souza Minayo",slug:"maria-cecilia-de-souza-minayo",fullName:"Maria Cecília De Souza Minayo"},{id:"417623",title:"Dr.",name:"Camila",surname:"Alves Bahia",slug:"camila-alves-bahia",fullName:"Camila Alves Bahia"}],corrections:null},{id:"78040",title:"Risk Suicide, Anxiety, and Coping Strategies",doi:"10.5772/intechopen.99618",slug:"risk-suicide-anxiety-and-coping-strategies",totalDownloads:109,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this paper, we sought to examine the levels of suicidal risk and anxiety, as well as the coping strategies used in a sample of 154 Spanish university students, most of them first-year students, during the situation of confinement and the pandemic. After approval by the Ethics Committee, instruments for the evaluation of these constructs were administered. An ex post facto design was used. A high level of suicide risk was not found in the sample. Statistically significant differences were found in the levels of suicidal risk and anxiety according to gender, with higher scores in both variables for women. Likewise, the coping strategies of self-criticism and social withdrawal show direct associations with the levels of suicidal risk. We conclude by pointing out the relevance of the data obtained for a more effective design of psychoeducational interventions to face these public health problems with the training of effective coping strategies.",signatures:"Francisco Manuel Morales Rodríguez",downloadPdfUrl:"/chapter/pdf-download/78040",previewPdfUrl:"/chapter/pdf-preview/78040",authors:[{id:"357520",title:"Prof.",name:"Francisco Manuel",surname:"Morales Rodríguez",slug:"francisco-manuel-morales-rodriguez",fullName:"Francisco Manuel Morales Rodríguez"}],corrections:null},{id:"77918",title:"The Fallacy of Happiness: A Psychological Investigation of Suicide among Successful People",doi:"10.5772/intechopen.99425",slug:"the-fallacy-of-happiness-a-psychological-investigation-of-suicide-among-successful-people",totalDownloads:264,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"There are three feelings that prompt a person to take their life: hopelessness, helplessness and worthlessness. Studies have found that the risk of suicide increases with decreasing happiness. In the recent past, people have been left clueless when celebrities and successful people ended their lives despite appearing overtly happy. What prompted them to do so? Modern society today highlights the importance of success over failure. Although we are motivated to be successful in life, it should not become our main gauge of happiness. In the same way we should not let success be our main goal in life and get discouraged by failure. Happiness has been viewed in two ways: as concerning the well-being of a person, and as the opposite of depression. Each one of us has different ways of measuring happiness. The quality of one’s happiness depends on one’s priorities in life. Happiness is not merely something that can be quantified with how much success and failure one has because such metric is very much subjective. How do we prevent a young life from extinguishing? How do we identify suicidal behavior among successful people and help those around? The present chapter covers the possible reasons why successful people commit suicide. Role of media in preventing suicide and measures for preventing suicide by successful people has been discussed.",signatures:"Nishi Misra and Shobhna Srivastava",downloadPdfUrl:"/chapter/pdf-download/77918",previewPdfUrl:"/chapter/pdf-preview/77918",authors:[{id:"308037",title:"Dr.",name:"Nishi",surname:"Misra",slug:"nishi-misra",fullName:"Nishi Misra"},{id:"425053",title:"Ms.",name:"Shobhna",surname:"Srivastava",slug:"shobhna-srivastava",fullName:"Shobhna Srivastava"}],corrections:null},{id:"77672",title:"Suicide Following Traumatic Brain Injury: Pathogenesis and Neurocognitive Mechanisms",doi:"10.5772/intechopen.99259",slug:"suicide-following-traumatic-brain-injury-pathogenesis-and-neurocognitive-mechanisms",totalDownloads:148,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Traumatic brain injury (TBI) is associated with varied neuropsychiatric sequelae, including elevated risk for later suicidal behaviors (SBs). This chapter provides a qualitative narrative review of hypothesized biological and neurocognitive mechanisms linking TBI to subsequent SBs. The following selective review specifically highlights: (1) Structural and functional alterations to neural circuitry secondary to common head injuries (e.g., concussions or mild TBI) as well as severe or repetitive TBI (e.g., chronic traumatic encephalopathy); (2) Overlap between post-TBI neuropsychological deficits and proposed bio-behavioral indicators of suicide risk; and (3) Potential neurocognitive mediators of the relationship between TBI and SBs, with a particular focus on executive functions involved in self-regulation (i.e., cognitive and affective inhibitory control) and their neural substrates, e.g., corticolimbic, frontostriatal, and frontoparietal circuitry. The chapter concludes with theoretical and practical implications of this shared pathophysiology, based on the reviewed empirical literature.",signatures:"Kenneth J.D. 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The disease not only can transmit from animal to animal but also transfer from animal to human through the parasite, virus, and bacteria [1]. The sudden invasion of infectious disease is a critical objective for the quietly alive of people in the ground [2]. However, it is not always an easy task to identify and anticipate the small pathogenic like small particles that are responsible for sudden chronic situations increasing incidence in geographic range [3]. Therefore, the situation demands to identify the unpredictable appearance of new infectious diseases as soon as possible that can utilize for further development of new therapeutic agents. Before identifying the causal infectious agents, the inevitable, but unpredictable, the appearance of newly emerging and re-emerging infectious diseases should be understood. The term emerging infectious diseases (EID) refers to infections that are newly arrived or evolved in a certain population, whose incidence can rapidly increase worldwide and threaten for future. On the other hand, infectious diseases that were previously appeared in the population and gradually decrease the incident but currently expanding into new geographical, host, or vector immensely that called re-emerging viral disease [4]. The virus disease has been recognized mostly from zoonotic by infecting a human. The primary source of zoonotic virus from farm and wild animal causes disease in human. Approximately 60 to 75% of known human pathogens ascend from animals [5]. Animal reservoirs have been involved in numerous virus families such as Filoviridae, Arenaviridae, Flaviviridae, and Bunyaviridae that were responsible to transmitted virus animals to humans
With the advancement of computational biology and immunoinformatics, rapid detection of pathogens and related proteins responsible for the disease has been developed. The technology helps to determine pathogen types within a short time and is utilized for therapeutic development. For example, immunoinformatic approaches can predict epitopes and their target protein is the recent advancement in vaccine design and development process that controlled the uses of antigen variation as well as hitting conserved epitopes [6]. It mainly designs immunogens by the protective responses of the target-specific receptor [7]. In the consequences of DNA virus infection and replication, it first attaches to the outer cell of the host through the protein receptor and replicates DNA by using host cell enzymes [8]. Finally, DNA goes to messenger RNA and translates it into a viral protein. Complete viral particles have converted by the replicate DNA and viral protein when new viruses were released from the host cell [9]. Additionally, RNA viruses are operated precisely as messenger RNA to make viral proteins. This mechanism of viral infections can be predicted through computational tools and immunoinformatics can identify desired epitopes for designing vaccines against the infections. On the other hand, computer-aided drug design (CADD) consists of a computer-assisted
Furthermore, consistent advancement of medical and pharmaceutical research has been playing an important role in the proper solution of several diseases but remained some problems with viral disease that may suffer or burden to public and animal health [11]. Therefore, computational techniques have opened a new avenue for minimizing the problems of drug discovery. The pharmaceutical industry has been starting to take up help from computational methods for drug design and development, drug repurposing, enlightening medicinal efficiency, and clinical trial [12]. The increasing data digitalization in a pharmaceutical company can be solved clinical problems that can also be done through computational methods. They have maintained a large volume of data for solving infectious diseases by their automation. The extremely widespread diseases remain virus diseases that cause infection by a type of microorganisms [13]. The most prominent type of virus diseases is common cold, while another one is an infection of virus that affected the upper respiratory tract such as nose and throat [14]. Furthermore, antibiotics have a magical role in preventing bacterial disease and infections but have no effects on viral disease. The most significant challenge to the researcher is finding out the epidemiology, vaccine design, and eradication in a worthwhile manner [15].
Infectious disease is a kind of disorder that is caused by one or more organisms. Many organisms consist of our body where some are normally helpful or infectious with parasites and viruses as well as bacteria and fungi [16]. SARS, recently emerged SARS-CoV-2, tuberculosis (TB), HIV/AIDS, influenza, Chickenpox, the common cold, and Hepatitis A and B are some examples of infectious diseases that can easily transmit from human to human or animal to human under adverse conditions and help to cause diseases. However, the animals or insects are directly or indirectly responsible for transmission to these organisms. Contaminated food items have exposed some infectious to the new environment and move apart from diseases [17]. There are various signs and symptoms of infectious diseases such as fever, fatigue, coughing, muscle aches, and diarrhea, and so on. Infectious diseases can be remedied or controlled by vaccines, but it takes a long time for application. Most infectious diseases controlled by consciousness of diseases such as handwashing can help to protect from many infectious diseases [18].
Over the last few centuries, millions of people have lost their lives to infectious diseases throughout the world. The risk of public health has been reduced and controlled through the improvement of the sanitation system, the progress of antibiotics and vaccines, living condition, and food quality, which is linked to the socioeconomic modernization of these societies [16]. Despite the improvement of health care facilities and surveillance systems, there have been some uncertainties that still now lead to an increase the human mortality from infectious diseases. The current threat to global human health is zoonoses [19]. The mutually transmitted 200 diseases occurred between humans and animals. The zoonotic disease has been increasing due to the overpopulation, wars, and food scarcity that are associated with humans who contract face to face [20]. However, the global death increased in 2010 due to infectious disease from HIV/AIDS that constitutes 1.5 million, and hereby malaria raised to 1.17 million [21]. At the same time, about 152,000 people died by the neglected tropical disease, and 1.2 million people died of tuberculosis [22]. Long-term illness, disability, and social stigma are occurring from poverty and are renamed by infectious diseases of poverty (IDoP). Moreover, coronavirus disease 2019 (COVID-19) has the main worldwide burden in this era expressing itself as a pandemic and killed almost 4,825,433 people from the beginning and has been infecting till now [23]. The global health system has been affected by the pandemic due to the unintentional interruption of service delivery. Until now, a total of 369 infectious diseases have been identified based-on mortality and the estimation of life expectancy according to global burden diseases in 2020. There are several factors responsible for diseases that have compiled during the COVID-19 pandemic by analyzing 286 causes of death, about 369 injuries and infections, and 87 threat issues from the 204 nations [24].
Several infectious pathogens have been halting their activities from the initial discovery and reappearance after a long and short period in several places [25]. Among them are Emerging and Re-Emerging Infectious Diseases (EIDs). They are types of infections that have newly originated or previously existed in a population that is rapidly increasing in incidence or geographic range. The newly emerging and re-emerging viral disease has threatened public and animal health, which is increasing due to human activities [26]. There are many associated factors related to the spread of infectious viral disease from one place to another place such as population migration, urbanization, public gathering, poverty, malnutrition, increased domestic and global connectivity and environmental changes, and so on [4]. The alteration of genetic phenomena has also been responsible for to spread of disease to a greater extent. Most of the infectious diseases have been estimated in zoonotic that constituted 60 to 70% of total diseases [27]. Hence, the animal virus also mutated with a human virus that accelerates infectious viral disease and generates the chronic problem. As a result, thousands of people die without medicine or even without knowing about the threat [28]. Novel pathogens have occurred due to unplanned urbanization of habitat destruction that enhances the contact or susceptibility to infections between human and animal vectors of viral diseases herewith the lack of immunity of these communities [29]. However, many pathogens re-emerging again after many years such as Chikungunya and Zika virus.
Initially, there was an outbreak of chikungunya between 1963 and 1973 with serious arboviral illness and it re-emerged in 2006, which firstly was observed in the East African strain of chikungunya [30]. Similarly, the Zika virus was initially associated with a serious illness that has conducted by serological studies in 1960 and after a long time, it has identified and reported from Brazil in 2015 [31]. The discovery of novel pathogens in the world has not been clogged and they are associated with economic cost reflect the burden for many developed and underdeveloped countries (Table 1). The high cost of medical and intensive care has been banned for all kinds of work from the affected region.
Family | Pandemic Year | Viruses | Probable/mode of transmission | Outbreak potential |
---|---|---|---|---|
Bunyaviridae | 1917 | Ganjam virus or Nairobi sheep disease virus (NSDV) | Tick-borne | Yes* |
1954 | Bhanja virus | Tick-borne | Yes* | |
2009 | SFTS virus | Tick-borne | Yes | |
1719 | Chobar Gorge virus | Tick-borne | No | |
2008 | EEV | Arthropod-borne | No | |
2004 | Cat Que. virus | Arthropod-borne | Yes* | |
1957 | Kaisodi virus | Tick-borne | Yes* | |
1955 | Umbre virus | Arthropod-borne | Yes* | |
1965 | Ingwavuma virus | Arthropod-borne | No | |
1957 | Chittoor virus | Tick-borne | Yes* | |
1964 | Thottapalayam virus | Rodent-borne | No | |
Nairoviridae | 1944 | CCHFs virus | Tick-borne, human to human | Yes |
Flaviviridae | 1955 | Yellow fever | Arthropod-borne | Yes |
1947 | Zika virus | Arthropod-borne, mother to child, sexual route | Yes | |
1957 | KFD | Tick-borne | Yes | |
1952 | JE | Arthropod-borne | Yes | |
1992 | Dengue | Arthropod-borne | Yes | |
1966 | Bagaza virus | Arthropod-borne | Yes* | |
Paramyxoviridae | 1968 | Influenza - (H3N2) v alias | Air-borne | Yes |
2004 | Avian Influenza | Air-borne | Yes | |
2006 | Influenza -Avian (H5N1) | Air-borne | ||
1956 | RSV | Air-borne | Yes | |
1953 | Quaranfil virus | Tick-borne | Yes* | |
late 1950s | Parainfluenza 1–4 | Air-borne | Yes* | |
2009 | Influenza H1N1 | Air-borne | ||
1962 | Enterovirus-D68 | Air-borne | Yes | |
Paramyxoviridae | 2001 | Nipah virus | Human to human | Yes |
Direct contact/consumption of infected bat/fruit infected with bat | ||||
Picornaviridae | 1953 | Human rhinovirus A, B and C | Air-borne | Yes |
1957 | Hand, foot and mouth disease | Direct contact, feco-oral route | Yes | |
1948–49 | Coxsackie-A21 virus | Feco-oral route | Yes | |
1948–1949 | Coxsackie-A10 virus | Feco-oral route | Yes | |
1977 | Sapoviruses | Feco-oral route | Yes | |
1973 | Rota | Feco-oral route | Yes | |
1997 | Polio and non-polio flaccid paralysis | Feco-oral route | Yes | |
Caliciviridae | 1936 | Noroviruses | Feco-oral route | Yes |
Hepadnaviridae | 2007 | Hepatitis KIs virus new and vaccine escape mutants of HBV | Blood-borne | Yes |
Togaviridae | 1740 | Rubella virus | Air-borne | Yes |
2005 | Chikungunya virus | Arthropod-borne | Yes | |
Poxviridae | 1934 | Buffalopox virus (orthopoxvirus) | Direct contact | Yes |
1958 | Human monkey pox | Air-borne | ||
Parvoviridae | 1975 | Human parvovirus 4 | Parenteral transmission? | Yes |
Arenaviridae | 1934 | LCMV | Rodent-borne | Yes* |
Herpesviridae | 1934 | CMV | Direct contact | Yes |
1974 | Chickenpox (varicella) VZV | Air-borne, direct contact | Yes | |
Rhabdoviridae | 1965 | Chandipura virus | Arthropod-borne | Yes |
Reoviridae | 1963 | Kammavanpettai virus (orbiviruses) | Tick-borne | No |
Coronaviridae | 2003 | SARS Coronavirus | Air-borne | Yes |
2019 | Coronavirus disease-2019 (COVID-19) | Air-borne | Yes | |
Polyomaviridae | 1953 | Polyoma-like virus | Human to human | Yes |
Phenuiviridae | 1931 | Rift valley fever | Blood-borne | Yes |
Viral diseases have chorionic effects on public health worldwide. The annual death has been attributed to about 20 million by infectious diseases [34]. Most of the death not only occurred by acute respiratory tract infection and gastrointestinal infections but also come out through tuberculosis and malaria that remained unchanged till now [35]. Many factors have been leading to emerging and re-emerging infectious diseases such as demographic factors, population distribution, sexual behavior, childcare, food-borne and water-borne diseases, ecological alteration and land use, chronic manifestations, enhanced pathogen detection, microbial evolution, and failure of community health scheme and bioterrorism shown in Figure 1 [36]. The variations of the global population have been contributing to the growth and density in per capita, resettlement to the city area, international tourism, migration, and retaining density that directly or indirectly leads to the infectious virus disease [37]. However, there are some intentional reasons too responsible for the emerging and re-emerging virus such as the deliverance of sexual practice, enhanced childcare beyond the family, alcohol and drug abuse, food supply, transportation, and immunization practices [32]. Moreover, the environmental and land use causes of global warming, deforestation, and natural disasters such as floods, drought, and
Representing different factors that influence the activities of emerging and re-emerging viral bond diseases.
Due to the degradation of the environment, many contagious infections spread out the world for a long time. However, some diseases have been treated through the antibiotic and controlled with the vaccine but most of the disease’s remedies remained unchanged still now [41]. Scientists and researchers have been searching for a new link in an infectious chain through their internal activities. The consumption of raw food is one of the triggers of infectious diseases. Raw food usually has lots of harmful microorganisms that can hamper your normal life within a short time [41]. Several factors have been contributing to the vast range of emerging and non-emerging diseases such as changes in human behaviors, enhancement of technology, change in the land pattern and economic progress, tourism, microbial change, and collapse of public health measures [41]. However, the prevention and control have been taken by the Pan American Health Organization (PAHO) that regulates some measures of emerging and re-emerging diseases [42]. First, there is need to increase and strengthen regional surveillance networks that control infectious diseases from one place to another place. Later, the rapid responses of infectious diseases thereby enhance the laboratory equipment and training. Moreover, the development of applied research fields can prevent the disease through the rapid diagnosis of epidemiology as well as prevention [43]. Finally, the enhancement of regional capacity and strength can control and prevent emerging and re-emerging diseases through effective implementation [44].
Emerging viral diseases have occurred previously and resultant pandemics where plant derived was the first choice for treatment. Around 1500 BC, Egyptians were started herbal drug preparation by the medicinal plant where later Greek and Roman have improved it [45]. Emerging infectious diseases have been treated traditionally by the medicinal plant before inventing a drug or vaccine [46, 47]. In China, it was widely used to deal with infectious diseases. They believe that it boosts the immune system and protects the virus to enter the respiratory tract [48]. Many medicinal herbs have a unique antiviral effect and are used as a substitute for an antimicrobial drug against infectious diseases. They have used the whole body of herb or part of the plant such as leaves, roots, bark, fruit, seeds, flowers, and so on, for preventing and healing respiratory tract infections [49]. In the modern time, it has been perceived that the traditional drug safer and healthier than synthetic drug those comes from plant-based traditional medicine. Plant-derived drug discovery has been renowned for the last decade [50]. It is considered that plant products will be an indispensable source of a new drug in the future.
Pharmacophore is one of the most promising
Pharmacophore model-based virtual screening process for identification of small molecular candidates against a specific disease.
In modern drug design and discovery, molecular docking is one of the foremost strategies to find the best molecules for a specific target. It assists to predict the interaction of protein and a ligand at the bond stage. Molecular docking is used to calculate the scoring function by sampling algorithms shown in Figure 3 [54]. Furthermore, it is reasonable, time demanding, and effective more than any conventional technology. The computer-based drug designing method predicts the function of any individual protein of interest that conducts a very comprehensive approach [55]. It has various applications among them protein-ligand docking is one of them. It is primarily designed to predict the binding of small drug molecules from medicinal herbs or plants, invertebrates, and so on to target proteins [56]. The number of diseases is caused by the harmful receptors; hence, docking is designed to inhibit or induce the target protein. However, the discovery of drugs in the traditional way is very expensive because of the need to search a large volume of compounds to select against a particular protein for the proper binding interaction and targeting diseases [57]. Therefore, computerized docking can screen virtually thousands of compounds in a short time by experimental high-throughput screening and confirmed the ligand and receptor for stable binding. It also provides the knowledge-based scoring functions that interact with atom pairs between protein and ligand complexes along with three-dimensional structure. There are several purposes of molecular drug design [58]. Among them, three are main purposes such as predicting the active ligand, binding affinities, and identifying new ligand. Based on molecular docking, it has numerous applications such as documenting the lowest free energy structure for the receptor-ligand complex, estimating the differential binding of a ligand of two separate macromolecular receptors, the geometry of the specific ligand-receptor complex, lead generation and optimization for future drug candidate, and so on [59].
Molecular docking-based screening approaches of small molecules against a specific target.
Molecular dynamics (MD) simulation is a computer-based simulation technique that mainly analyzed the physical motion of atoms and molecules across a specific conformational space [60]. MD simulation is the unique way to drug discovery in the present era that led to work in a wet lab after computer simulation. The MD simulation ensures the detail of the dynamic properties of selected protein and plays a key role in the modeling and characterization of a protein [61]. The MD simulation also helps to determine the stability of a ligand to the active site of the targeted macromolecules. Moreover, MD simulation not only provides the information of the ligand optimization process at the qualitative level but also estimates accurately in ligand binding affinities. The tiny, microscopic event (protein-ligand interaction and molecular motion) occurs with a micro- or nano-second time scale that is not possible to determine without the technique [62]. Finally, dynamic simulation is a faster, reasonable, widely accessible, and perfect method for drug design
Quantum mechanics has been leading a valuable method for drug discovery through characterizing the structure, dynamics, and energies of protein-ligand interaction [66]. In the medicinal industry and academic research, it is an inevitable part of drug design that fixes the problem by calculating chemical reactivity and helps to optimize structure [67]. The new drug candidate has been chosen by molecular mechanics (MM) but the quantum mechanics (QM)-based approach provides accurate accuracy and efficiency in the complexity of protein-ligand interactions [68]. Furthermore, it does not provide only the estimation of being affinities, determining ligand energies and bioactive conformations, refinement of molecular geometries but also added scoring docked ligand poses, describing molecular similarity, structure-activity, relationship analysis, and ADMET prediction in the activities of drug design [69]. QM is getting popular day by day in drug discovery because of the improving power or speed of the computer that led to advanced QM algorithm progress as well as a new application to address the shortcoming [70]. The popular method of fragment molecular orbital (FMO) offers a wide range of solutions where there are combined accuracy, speed, and the ability to characterize important interaction such as strength in kcal/mol as well as hydrophobic, electrostatic, and so on. In summary, FMO analyzed the length such as polarization, desolation, and interaction with the illustrated for a water dimer and protein-ligand complex [71].
Pharmacokinetics is the unique part of the drug design where the time course study is done through the mathematical characterization for absorption of drug, distribution, metabolism as well as excretion (ADME) [72]. Therefore, before the clinical trial, it is the advanced procedure to select a drug for the development and decision-maker by AMDE test [73]. As a result, it is safe and effective for a specific patient by decreasing toxicity and increasing efficacy in drug therapy. However, the central compartment of the human body was interconnected by a series of compartments reversibly on the base of pharmacokinetic [74]. Therefore, drugs enter each compartment and are distributed homogenously to display consistent kinetics. Hence, it is separated by a mathematical model where AMDE can differ in each compartment and help to predict drug metabolisms or actions [75]. Moreover, the central compartment received drug and entry on the body called absorption. The drug is distributed to the peripheral compartment after absorbing into the body and beginning the metabolic processes. Finally, the excretion of the drug from the body is in three ways such as hydrophilic molecules by the renal system, hydrophobic molecules by the biliary system, and volatile substances by the pulmonary system [76].
In the drug discovery, peptides are not new, but it makes a choice drug candidate in the challenging situation with the collaboration of immunoinformatics. Immunoinformatics can be developed as natural endogenous scaffolds with familiar biological activities for solving challenging medical problems by it distinguishing characteristics such as the ability to act firstly, more specific, the minimum range of toxicity, and so on [77]. Approximately 55 therapeutic peptides have been approved for clinical trial through the regulatory agency [78]. Currently, many researchers have been working to solve various diseases through antimicrobial peptide design. The target of antimicrobial peptides has accelerated through the deep generative models and molecular dynamics. By utilizing the immunoinformatic approach, the researcher has developed 20 novel peptides that were validated through deep learning and high-throughput molecular simulation [79]. The peptides are not only used in broad-spectrum potency but also lead to multi-drug resistant strain and low toxicity. Immunoinformatic approaches help to observe peptide activity, selectivity, toxicity, ease of synthesis stability, etc. During the present situation of COVID-19, immunoinformatics help to identify peptide candidates from diverse viral sequences as shown in Figure 4, which can be utilized for vaccine design [80]. It is identified and designed from the motifs and subsequently a peptide library. As a result, strong binding affinities of peptides had happened with the main protease of SARS-CoC-2 as well as maintained stability and physiological condition observed by molecular dynamic simulation [81].
Immunoinformatics aided identification of peptide candidates and procedure for designing multi-epitope vaccine by utilizing the peptide.
Vaccine design is a very powerful tool for saving human life in the world broadly. The advancement of technology has been trigger to develop new strategies by the target and the structures of antibodies, hitting conserved epitopes and controlling the usage of antigenic variation [82]. It designed immunogens for provoking foreign responses because of no single or best solution of immune drugs design till now [83]. However, artificial intelligence and system biology together make an opportunity for avoiding inefficiencies and failures that help to classical vaccine development pipeline [84].
However, in the vaccine design process, DeepVacPerd is an efficient tool that predicts the best vaccine subunit candidates with 30 subunit candidates from the various protein sequences within a second by replacing the predicted and selected with deep neural network architecture [87]. Therefore, it has become a promising of higher efficiencies for the vaccine design and test process. Furthermore, systems biology developed various tools by analyzing large data set through the complex modeling interaction between the individual interaction [88]. The omics disciplines such as genomics, proteomics, metabolisms, and so on produced a simulation of the immune response, identified response-specific signature, and assessed their predictive value through the basilar idea with the integration of high-throughput data [89]. Therefore, several programs and consortiums have performed by developing novel analytic tools that may integrate the information from omics.
Personalized vaccine candidates are developed against a specific “targeted” to maintain an optimized outcome. Failure of the vaccine candidates can increase immunogenicity subsequently reactogenicity and adverse effects [90]. Therefore, the individual level, the gender level, the racial/ethnic level, and the subpopulation level should be considered during the personalized vaccine development process. Haplotype and polymorphism are mainly focused on the individual level selection as they can retard the formation of a protective immune response, where the gender level can determine the antibody tiger against a particular vaccine to males and females [91]. On the other hand, different human races or ethnic groups can show higher or lower immune responses to a specific vaccine candidate. Additionally, different interactions between host environmental, genetic, and some other factors may be influencing the vaccine immune responses; therefore, the subpopulation level should be also considered during vaccine design that can trigger an optimum immune response against a specific disease [92].
The study describes numerous computational tools that are widely used for drug and vaccine design against infectious viral diseases. However, improving ideas and methodologies can solve problems and provide system-level interconnected data. A promising idea accelerates the rational design of drug candidates that are used in the specific subfield. Here, we focused on computational methods that will help and provide a clear idea of modern drug and vaccine design approaches adequately.
The authors are in debt to King Abdulaziz University for their encouragements and unlimited support.
The authors declare no conflict of interest.
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Jansen",authors:[{id:"25232",title:"Prof.",name:"Sukumaran",middleName:null,surname:"Anil",slug:"sukumaran-anil",fullName:"Sukumaran Anil"},{id:"28373",title:"Prof.",name:"John",middleName:null,surname:"Jansen",slug:"john-jansen",fullName:"John Jansen"},{id:"77058",title:"Dr.",name:"Seham",middleName:null,surname:"Alyafei",slug:"seham-alyafei",fullName:"Seham Alyafei"},{id:"82073",title:"Dr.",name:"Subhash",middleName:null,surname:"Narayanan",slug:"subhash-narayanan",fullName:"Subhash Narayanan"}]},{id:"18415",doi:"10.5772/16936",title:"Osseointegration and Bioscience of Implant Surfaces - Current Concepts at Bone-Implant Interface",slug:"osseointegration-and-bioscience-of-implant-surfaces-current-concepts-at-bone-implant-interface",totalDownloads:12502,totalCrossrefCites:16,totalDimensionsCites:42,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Mustafa Ramazanoglu and Yoshiki Oshida",authors:[{id:"26726",title:"Prof.",name:"Yoshiki",middleName:null,surname:"Oshida",slug:"yoshiki-oshida",fullName:"Yoshiki Oshida"},{id:"29841",title:"Prof.",name:"Mustafa",middleName:null,surname:"Ramazanoglu",slug:"mustafa-ramazanoglu",fullName:"Mustafa Ramazanoglu"}]},{id:"18426",doi:"10.5772/18746",title:"Factors Affecting the Success of Dental Implants",slug:"factors-affecting-the-success-of-dental-implants",totalDownloads:17474,totalCrossrefCites:9,totalDimensionsCites:35,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Carlos Nelson Elias",authors:[{id:"32438",title:"Prof.",name:"Carlos",middleName:null,surname:"Elias",slug:"carlos-elias",fullName:"Carlos Elias"}]},{id:"18414",doi:"10.5772/17512",title:"Dental Implant Surfaces – Physicochemical Properties, Biological Performance, and Trends",slug:"dental-implant-surfaces-physicochemical-properties-biological-performance-and-trends",totalDownloads:13080,totalCrossrefCites:5,totalDimensionsCites:30,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Ahmed M. Ballo, Omar Omar, Wei Xia and Anders Palmquist",authors:[{id:"19042",title:"Dr.",name:"Wei",middleName:null,surname:"Xia",slug:"wei-xia",fullName:"Wei Xia"},{id:"28549",title:"Dr.",name:"Ahmed",middleName:"M.",surname:"Ballo",slug:"ahmed-ballo",fullName:"Ahmed Ballo"},{id:"81291",title:"Dr.",name:"Omar",middleName:null,surname:"Omar",slug:"omar-omar",fullName:"Omar Omar"},{id:"81292",title:"Dr.",name:"Anders",middleName:null,surname:"Palmquist",slug:"anders-palmquist",fullName:"Anders Palmquist"}]},{id:"18417",doi:"10.5772/18309",title:"Implant Stability - Measuring Devices and Randomized Clinical Trial for ISQ Value Change Pattern Measured from Two Different Directions by Magnetic RFA",slug:"implant-stability-measuring-devices-and-randomized-clinical-trial-for-isq-value-change-pattern-measu",totalDownloads:13176,totalCrossrefCites:8,totalDimensionsCites:19,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Jong-Chul Park, Jung-Woo Lee, Soung-Min Kim and Jong-Ho Lee",authors:[{id:"31057",title:"Prof.",name:"Jong-Ho",middleName:null,surname:"Lee",slug:"jong-ho-lee",fullName:"Jong-Ho Lee"},{id:"48351",title:"Prof.",name:"Jong-Chul",middleName:null,surname:"Park",slug:"jong-chul-park",fullName:"Jong-Chul Park"},{id:"83313",title:"Dr.",name:"JungWoo",middleName:null,surname:"Lee",slug:"jungwoo-lee",fullName:"JungWoo Lee"}]}],mostDownloadedChaptersLast30Days:[{id:"18432",title:"Clinical Complications of Dental Implants",slug:"clinical-complications-of-dental-implants",totalDownloads:56478,totalCrossrefCites:2,totalDimensionsCites:5,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Su-Gwan Kim",authors:[{id:"27797",title:"Prof.",name:"Su-Gwan",middleName:null,surname:"Kim",slug:"su-gwan-kim",fullName:"Su-Gwan Kim"}]},{id:"47927",title:"Miniscrew Applications in Orthodontics",slug:"miniscrew-applications-in-orthodontics",totalDownloads:4697,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"4548",slug:"current-concepts-in-dental-implantology",title:"Current Concepts in Dental Implantology",fullTitle:"Current Concepts in Dental Implantology"},signatures:"Fatma Deniz Uzuner and Belma Işık Aslan",authors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan"},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner"}]},{id:"50308",title:"Antibiotics in Implant Dentistry",slug:"antibiotics-in-implant-dentistry",totalDownloads:2369,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Antibiotics have been recommended either as an extended treatment for several days or as a single antibiotic prophylaxis dose since the development of dental implant osseointegration technique in the 1970s. It is also performed as part of surgical protocol during the peri-operative phase in the treatment of peri-implantitis. To date, there is a lack of scientific evidence regarding the additive effect of antibiotics in the treatment of dental implant. This has thus left the clinician with inconclusive recommendations, leading to increase antibiotic prescription. With this increase, the development of antibiotic resistance is becoming a threat to modern healthcare that requires revisiting of current indications and implementation of rational treatment strategies. Therefore, more studies are needed to assess the benefit of antibiotic prescription and whether it is safe to refrain from its use.",book:{id:"5185",slug:"dental-implantology-and-biomaterial",title:"Dental Implantology and Biomaterial",fullTitle:"Dental Implantology and Biomaterial"},signatures:"Dalia Khalil, Bodil Lund and Margareta Hultin",authors:[{id:"179031",title:"Dr.",name:"Dalia",middleName:null,surname:"Khalil",slug:"dalia-khalil",fullName:"Dalia Khalil"},{id:"185113",title:"Dr.",name:"Bodil",middleName:null,surname:"Lund",slug:"bodil-lund",fullName:"Bodil Lund"},{id:"185114",title:"Dr.",name:"Margareta",middleName:null,surname:"Hultin",slug:"margareta-hultin",fullName:"Margareta Hultin"}]},{id:"47915",title:"Rationale for Dental Implants",slug:"rationale-for-dental-implants",totalDownloads:3076,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"4548",slug:"current-concepts-in-dental-implantology",title:"Current Concepts in Dental Implantology",fullTitle:"Current Concepts in Dental Implantology"},signatures:"Ilser Turkyilmaz and Gokce Soganci",authors:[{id:"171984",title:"Associate Prof.",name:"Ilser",middleName:null,surname:"Turkyilmaz",slug:"ilser-turkyilmaz",fullName:"Ilser Turkyilmaz"}]},{id:"18430",title:"An Important Dilemma in Treatment Planning: Implant or Endodontic Therapy?",slug:"an-important-dilemma-in-treatment-planning-implant-or-endodontic-therapy-",totalDownloads:6264,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Funda Kont Cobankara and Sema Belli",authors:[{id:"28846",title:"Dr.",name:"Funda",middleName:null,surname:"Kont Çobankara",slug:"funda-kont-cobankara",fullName:"Funda Kont Çobankara"},{id:"75862",title:"Prof.",name:"Sema",middleName:null,surname:"Belli",slug:"sema-belli",fullName:"Sema Belli"}]}],onlineFirstChaptersFilter:{topicId:"998",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81595",title:"Prosthetic Concepts in Dental Implantology",slug:"prosthetic-concepts-in-dental-implantology",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.104725",abstract:"This chapter will address evidence-based prosthetic concepts in dental implantology as well as clinical evidence with focus on appropriate logic and technical skills. Those prosthetic factors are as just important as surgical factors, and long-term success can only be achieved if both of those factors are considered, respected, and strictly followed from planning to prosthetic phase of treatment. This chapter will deal with materials selection for prosthetic part, shape, size, and design of supracrestal parts of abutments and their influence on soft tissue and bone stability around dental implants. Furthermore, one of most important decisions is about choosing the proper way of retention: screw- vs. cement-retained restorations, and it will be discussed in detail. Additionally, emergence profile and its function in soft tissues adaptation and adhesion to different prosthetic materials also have important role in long-term success of dental implant restorations.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Ivica Pelivan"},{id:"80500",title:"Novel Dental Implants with Herbal Composites: A Review",slug:"novel-dental-implants-with-herbal-composites-a-review",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.101489",abstract:"Missing a permanent tooth is a miserable condition faced by a common man. A tooth decay, periodontitis, mechanical trauma, or any systemic complications lead to such a complication. These bone defects when left untreated lead to severe resorption of the alveolar bone. A proper dental filling with an appropriate bone substitute material could prevent such resorption and paves a way for subsequent implant placement. Dental implants are considered as the prime option by dentists to replace a single tooth or prevent bone resorption. A variety of bone substitutes are available differ in origin, consistency, particle size, porosity, and resorption characteristics. Herbal composites in dentistry fabricated using biphospho-calcium phosphate, casein, chitosan, and certain herbal extracts of Cassia occidentalis, Terminalia arjuna bark, Myristica fragans also were reported to possess a higher ossification property, osteogenic property and were able to repair bone defects. C. occidentalis was reported to stimulate mineralization of the bone and osteoblastic differentiation through the activation of the PI3K-Akt/MAPKs pathway in MC3T3-E1 cells of mice. This implant proved better osteoconductivity and bioactivity compared to pure HAP and other BCP ratios. Terminalia Arjuna was also worked in the incorporation in the graft to enhance the osteogenic property of the implant and gave good results. Another implant bone graft was synthesized containing BCP, biocompatible casein, and the extracts of Myristica fragans and subjected to in vitro investigations and the results revealed the deposition of apatite on the graft after immersing in SBF and also the ALP activity was high when treated with MG-63 cells, NIH-3 T3, and Saos 2 cell lines. This study indicates that the inclusion of plant extract enhances the osteogenic property of the graft. Thus, these novel dental implants incorporated with herbal composites evaluated by researchers revealed an enhanced bone healing, accelerates osseointegration, inhibits osteopenia, and inhibits inflammation. This application of herbal composite inclusion in dentistry and its applications has a greater potential to improve the success rate of dental implants and allows the implications of biotechnology in implant dentistry.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Gopathy Sridevi and Seshadri Srividya"},{id:"78320",title:"Implant-Retained Maxillary and Mandibular Overdentures - A Solution for Completely Edentulous Patients",slug:"implant-retained-maxillary-and-mandibular-overdentures-a-solution-for-completely-edentulous-patients",totalDownloads:66,totalDimensionsCites:0,doi:"10.5772/intechopen.99575",abstract:"The main goal of modern removable prosthodontics is to restore the normal appearance, function, esthetics and speech in each completely edentulous patient. However, if all teeth are missing in a patient, it becomes very complicated to achieve it using traditional protocols. Therefore, implants were introduced into removable prosthodontics to ensure better retention and stability of the conventional dentures. In case of a large amount of bone missing in the jaw it is necessary to ensure the functioning of the dentures constructing various additional stabilizing and retentive prosthodontic solutions on the osseointegrated implants. Numerous types of attachment systems have been used recently for relating implant-retained overdentures to underlying implants: basically splinting (various bar shape designs) and non-splinting attachments (various ball type attachment, magnet attachment, telescopic coping systems). Indications for their use depend on the surgical and prosthodontic factors such as the number and position of the implants, the amount of free intermaxillary space and the type and size of the overdentures. Different indications, types of the overdentures and the attachment systems will be discussed in this chapter.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Dubravka Knezović Zlatarić, Robert Ćelić and Hrvoje Pezo"},{id:"79724",title:"Implant Stability Quotient (ISQ): A Reliable Guide for Implant Treatment",slug:"implant-stability-quotient-isq-a-reliable-guide-for-implant-treatment",totalDownloads:60,totalDimensionsCites:0,doi:"10.5772/intechopen.101359",abstract:"Implant stability is a prerequisite for successful dental implants and osseointegration. To determine the status of implant stability, continuous monitoring in an objective and qualitative manner is important. To measure implant stability two different stages are there: Primary and secondary. Primary implant stability at placement is a mechanical phenomenon that is related to the local bone quality and quantity, the type of implant and placement technique used. Primary stability is checked from mechanical engagement with cortical bone. Secondary stability is developed from regeneration and remodeling of the bone and tissue around the implant after insertion and affected by the primary stability, bone formation and remodeling. Implant stability is essential for the time of functional loading. Classical benchmark methods to measure implant stability were radiographs or microscopic analysis, removal torque, push-through and pull-through but due to lack of feasibility, time consumption and ethical reasons other methods have been propounded over period of time like measurement of implant torque, model analysis and most important ISQ which has the ability to monitor osseointegration and the life expectancy of an implant. ISQ is a valuable diagnostic and clinical tool that has far-reaching consequences on implant dentistry and this article throws light on advanced and reliable methods of assessing ISQ.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Gaurav Gupta"},{id:"79817",title:"Peri-Implant Soft Tissue Augmentation",slug:"peri-implant-soft-tissue-augmentation",totalDownloads:128,totalDimensionsCites:0,doi:"10.5772/intechopen.101336",abstract:"The peri-implant soft tissue (PIS) augmentation procedure has become an integral part of implant-prosthetic rehabilitation. Minimal width of keratinized mucosa (KM) of 2 mm is deemed necessary to facilitate oral hygiene maintenance around the implant and provide hard and soft peri-implant tissue stability. PIS thickness of at least 2 mm is recommended to achieve the esthetic appearance and prevent recessions around implant prosthetic rehabilitation. The autogenous soft tissue grafts can be divided into two groups based on their histological composition—free gingival graft (FGG) and connective tissue graft (CTG). FGG graft is used mainly to increase the width of keratinized mucosa while CTG augment the thickness of PIS. Both grafts are harvested from the same anatomical region—the palate. Alternatively, they can be harvested from the maxillary tuberosity. Soft tissue grafts can be also harvested as pedicle grafts, in case when the soft tissue graft remains attached to the donor site by one side preserving the blood supply from the donor region. Clinically this will result in less shrinkage of the graft postoperatively, improving the outcome of the augmentation procedure. To bypass the drawback connected with FGG or CTG harvesting, substitutional soft tissue grafts have been developed.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Marko Blašković and Dorotea Blašković"},{id:"79611",title:"Growth Factors and Dental Implantology",slug:"growth-factors-and-dental-implantology",totalDownloads:103,totalDimensionsCites:0,doi:"10.5772/intechopen.101082",abstract:"Normal healing procedure of bone involves various sequential events to develop bone and bridge the bone -to- bone gap. When this healing occurs with a metal (titanium) fixture on one side, it is called as osseointegration. After extensive studies on this topic, it is found that this procedure occurs in presence of various biologic constituents that are spontaneously released at the site. Thus, to accelerate normal healing after implant placement and make results more predictable, it has been proposed to use these autologous factors in the osteotomy site. Since it is the beginning of a new revolution in dental implantology, right now it is essential to analyze all possible combinations of host conditions, bone quality and quantity and bio factors being used. This can definitely be a boon for the patients with compromised systemic or local conditions.",book:{id:"10808",title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg"},signatures:"Deeksha Gupta"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. 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