Industrial applications of the main adhesives (adapted from ref. [1]).
\r\n\t(i) Quantum dots of very high-quality optical applications, Quantum dot light-emitting diodes (QD-LED) and ‘QD-White LED’, Quantum dot photodetectors (QDPs), Quantum dot solar cells (Photovoltaics).
\r\n\r\n\t(ii) Quantum Computing (quantum bits or ‘qubits’), (vii) The Future of Quantum Dots (broad range of real-time applications, magnetic quantum dots & graphene quantum dots), Superconducting Loop, Quantum Entanglement, Quantum Fingerprints.
\r\n\r\n\t(iii) Biomedical and Environmental Applications (to study intracellular processes, tumor targeting, in vivo observation of cell trafficking, diagnostics and cellular imaging at high resolutions), Bioconjugation, Cell Imaging, Photoelectrochemical Immunosensor, Membranes and Bacterial Cells, Resonance Energy-Transfer Processes, Evaluation of Drinking Water Quality, Water and Wastewater Treatment, Pollutant Control.
",isbn:"978-1-80356-594-1",printIsbn:"978-1-80356-593-4",pdfIsbn:"978-1-80356-595-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"0dd5611c62c91569bd2819e68852002a",bookSignature:"Prof. Jagannathan Thirumalai",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11756.jpg",keywords:"LED, Organic LEDs, Dyes & Pigments, Solar Cells, Laser Photonics, Electronic Switching Devices, Qubits, Josephson Junction, Bioconjugation, Cell Imaging, Photoelectrochemical Immunosensor, Membranes, and Bacterial Cells",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 16th 2022",dateEndSecondStepPublish:"May 27th 2022",dateEndThirdStepPublish:"July 26th 2022",dateEndFourthStepPublish:"October 14th 2022",dateEndFifthStepPublish:"December 13th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. J. Thirumalai received his Ph.D. from Alagappa University, Karaikudi, He was also awarded the Post-doctoral Fellowship from Pohang University of Science and Technology (POSTECH), the Republic of Korea. His research interests focus on luminescence, self-assembled nanomaterials, and thin-film optoelectronic devices. He has published more than 60 SCOPUS/ISI indexed papers and 11 book chapters, edited 4 books, and member of several national and international societies like RSC, OSA, etc. His h-index is 19.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"99242",title:"Prof.",name:"Jagannathan",middleName:null,surname:"Thirumalai",slug:"jagannathan-thirumalai",fullName:"Jagannathan Thirumalai",profilePictureURL:"https://mts.intechopen.com/storage/users/99242/images/system/99242.png",biography:"Dr. J. Thirumalai received his Ph.D. from Alagappa University, Karaikudi in 2010. He was also awarded the Post-doctoral Fellowship from Pohang University of Science and Technology (POSTECH), Republic of Korea, in 2013. He worked as Assistant Professor of Physics, B.S. Abdur Rahman University, Chennai, India (2011 to 2016). Currently, he is working as Senior Assistant Professor of Physics, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam (T.N.), India. His research interests focus on luminescence, self-assembled nanomaterials, and thin film opto-electronic devices. He has published more than 60 SCOPUS/ISI indexed papers and 11 book chapters, edited 4 books and member in several national and international societies like RSC, OSA, etc. Currently, he served as a principal investigator for a funded project towards the application of luminescence based thin film opto-electronic devices, funded by the Science and Engineering Research Board (SERB), India. As an expert in opto-electronics and nanotechnology area, he has been invited as external and internal examiners to MSc and PhD theses, invited to give talk in some forum, review papers for international and national journals.",institutionString:"SASTRA University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"10",totalChapterViews:"0",totalEditedBooks:"6",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"17",title:"Nanotechnology and Nanomaterials",slug:"nanotechnology-and-nanomaterials"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"347258",firstName:"Marica",lastName:"Novakovic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"marica@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"5348",title:"Luminescence",subtitle:"An 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The word ‘adhesive’ can be used either as a noun or as an adjective, defining substances which tend to adhere or stick to other substances. Adhesion refers to the interaction of the adhesive surface with the substrate surface, and it involves two dissimilar bodies being held in intimate contact such that mechanical force or work can be transferred across the interface. Several theories that explain the adhesion process have been postulated, the forces involved in the process being van der Waals forces, chemical bonding, or electrostatic attraction. On the other hand, the mechanical strength of the system depends not only on the interfacial forces but also on the mechanical properties of the interfacial area, as well as the two bulk phases [1, 2].
\nAdhesives were first mentioned in history 3300 years ago, when Egyptian carvings depicted the glueing of a piece of veneer to what appears to be plank of sycamore. In ancient and mediaeval times, bitumen, tree pitches and beeswax were used as sealants and adhesives [3]. In the nineteenth century, rubber cements were introduced, but decisive advances in adhesive technology awaited the twentieth century, when natural adhesives have been improved and many synthetics components have been developed. Adhesives are essential components of shoes, automobiles, cartons, furniture and non-woven fabrics and a host of other products. The aerospace field was the first sector that promoted the use of adhesives in the aircraft manufacturing process; hence, the growth of the aircraft and aerospace industries has influenced adhesive technology in a great extent. The requirement to get a high degree of structural strength and a high resistance to fatigue promoted the development and production of high-performance adhesive materials, which found various domestic and industrial applications [3, 4, 5].
\nThe raw materials used as adhesives are mainly polymeric materials, both natural and synthetic. Taking into consideration the costs, natural products (such as starch, dextrin, casein, naturally gums) are still important; however, synthetic ones have largely taken over the adhesive industry, both as modifiers of natural materials and, more importantly, as high-strength, moisture-resistant additives capable of being produced in many readily usable forms.
\nAmong the key factors influencing the evolution of adhesives are globalisation, the maturity of technological processes and governmental regulations worldwide, militating for the usage of non-volatile adhesives, including epoxies, cyanoacrylates and urethanes, to the detriment of solvent-based adhesives [6].
\nAdhesives are also used in the healthcare sector, thus having broad applications in dentistry, medical and pharmaceutical field. Various modern adhesives are used in medicine and dentistry, in direct physiological interactive modes or to assemble thousands of medical devices. In the pharmaceutical field, the use of adhesives aims to design modern pharmaceutical systems, in order to optimise drug release rate, as well as targeted drug delivery. This favours a more efficient use of the pharmacological potential of the active substance, leading to an increased treatment efficiency, with the reduction of overall dosages and hence of the adverse reactions [7, 8, 9].
\nNowadays, the focus is not only on the production of high-quality adhesives using modern technologies such as nanotechnology but also on the production of eco-friendly adhesives, named ‘green’ adhesives, for all domains of applicability [6, 10, 11, 12].
\nAdhesives are designed for specific applications. Besides their role in the adhesion process, they can be used for other purposes, such as sealing agents, in order to eliminate the effect of self-loosening caused by dynamic loads, sealing of areas to prevent oxidation and corrosion, waterproofing, etc. Sealants can be used as electrical or thermal insulators, fire barriers and products for smoothing, filleting or flying. The materials that are used as sealants have lower strength than those used as adhesives, because sealant formulations contain large amounts of inert filler material for cost reduction and gap filling purposes. Certain sealants, like adhesives, can be used to assemble parts, and many adhesives can be used to seal. The adhesives and sealants are mainly used to bond the following substrates: metals, plastics (thermosets and thermoplastics), composites, foams, elastomers, wood and wood products, glass and ceramics and sandwich and honeycomb structures [1, 2, 3, 5, 6].
\nThe main areas using industrial adhesives are the following:
Construction: floor tile and continuous flooring installation, ceramic tile installation, countertop lamination, manufacture of prefabricated beams and trusses, carpet adhesives, flooring underlayment adhesives, installation of prefinished panels, joint cements, drywall lamination adhesives and covering installations.
Consumer adhesives: model and hobby supplies, decorative films, school and stationery products.
Packaging: carton-side seam and closures, composite bonding of disposable products, bags, labels, cups, cigarette and filter manufacture, speciality packages (cosmetics, toiletries), composite containers and tubes.
Tapes: packaging, industrial, surgical, masking, and consumer tapes.
Transportation: auto, truck and bus assemblies, weatherstrip and gasket bonding, aircraft and aerospace structural assemblies.
Other rigid bondings: shake-proof fastening; furniture manufacture; manufacture of millwork, doors, kitchen cabinets and vanitories; appliance assembly and trim attachment; TV, radio and electronics assembly and machinery manufacture and assembly.
Other non-rigid bondings: apparel laminates, shoe assembly, sports equipment, book binding, rug backing, flock cements, air and liquid filter manufacture, etc. [1].
The main adhesives for industrial applications are summarised in Table 1.
\nAdhesive type | \nApplications | \nRefs. | \n
---|---|---|
Animal source: albumin, animal glue, casein, shellac, beeswax | \nWood industry Food industry | \n[13] | \n
Vegetable source: Natural resins: gum arabic, tragacanth, colophony | \nPaper, paperboard, light wood, cork | \n[14] | \n
Oils and waxes: carnauba wax, different oils | \nSealants in wood and metal industry | \n[15] | \n
Proteins: soybean Carbohydrates: starch, dextrin | \nWood industry Paper industry | \n[10, 15] | \n
Mineral: Inorganic minerals: silicates, magnesia, phosphates, sulphur Mineral waxes: paraffin Mineral resins: amber | \nWood industry | \n[1] | \n
Bitumen: asphalt | \nBinder in roads, roofing and flooring, installation of asphalt tile, sealant | \n[16] | \n
Natural rubber and derivatives | \nBonding paper, plastic, leather, shoe industry | \n[1] | \n
Synthetic rubber: butyl, polyisobutylene, polybutadiene blends, polyisoprenes, polychloroprene, polyurethane, silicone, polysulfide, polyolefins | \nBonding rubber to itself and plastic materials or metals; forms good bonding with most plastic films, glass, wood Some of them are sealants | \n[17, 18] | \n
Reclaimed rubber | \nBonding paper, rubber, plastic and ceramic tile, adhesive for electrical installations | \n[1] | \n
Neoprene rubber | \nBonding weather stripping and fibrous soundproofing materials to metal Sealant | \n[1] | \n
Nitrile rubber | \nBonding plastic films to metals and fibrous materials and nylon to nylon and other materials Sealant | \n[19] | \n
Cellulose derivatives: acetate, acetate-butyrate, caprate, nitrate, methyl cellulose, hydroxyl ethyl cellulose, ethyl cellulose, carboxymethyl cellulose | \nBonding non-metallic material: wood, leather, plastic, paper Used in packaging | \n[10, 20] | \n
Polyacrylates: methacrylate and acrylate polymers, cyanoacrylates | \nGenerally, adhesives for metals, some of them for plastic; thread lockers, thread sealants, retaining compounds, gasket Electronics, toys, cosmetic packaging, automotive sealants Bonds only to non-porous materials Glass industry | \n[16, 21] | \n
Anaerobic: based on synthetic resins (acrylates) | \nSecure, seal and retain machined, threated or similarly close-fitting parts | \n[22, 23, 24] | \n
Polyesters (saturated): polystyrene, polyamides | \nSealants for potting, moulding and encapsulating | \n[1] | \n
Vinyl polymers and copolymers: polyvinyl acetate, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride | \nBond porous materials Paper, wood and general packaging applications | \n[1] | \n
Amino plastics: urea and melamine formaldehydes | \nWood industry | \n[15] | \n
Epoxies: epoxy polyamide, epoxy bitumen, epoxy polysulfide, epoxy nylon | \nAbility to bond many substrates Sealants in constructions, electricity | \n[25] | \n
Phenolic resins and derivatives: phenol and resorcinol, formaldehydes, phenolic nitrile, phenolic neoprene, phenolic epoxy | \nWood industry Metal industry | \n[26, 27] | \n
Industrial applications of the main adhesives (adapted from ref. [1]).
The use of adhesives in the medical field has been restricted for a certain while, to the production of self-adhesive strips or plasters. The first reported pressure-sensitive adhesive used in the composition of bandage materials was natural rubber, followed by synthetic rubber, and, lastly, polyacrylic acid ester-based adhesives gained significance nowadays. Various medical adhesive tapes/dressings/devices are used to cover and protect wounds, to seal the skin edges of a wound or to support an injured part of the body [28, 29]. Advanced adhesives have a wide range of biomedical and pharmaceutical applications and are currently used in various medical procedures, as medical devices: restorative dental filings, blood transfusions, anaesthetic administration, intravenous drug delivery, heart bypass surgery, urological surgery and plastic surgery (Table 2) [7, 30, 31, 32, 33].
\nAdhesive type | \nApplications | \nRefs. | \n
---|---|---|
Albumin | \nHaemostat in vascular and cardiac surgeries | \n[64, 76] | \n
Alginate | \nBinds the tissue, even after exposure to an aqueous environment Adhesive, pharmaceutical excipient: stabilising agent, tablet and capsule disintegrant, tablet binder | \n[76, 77] | \n
Chitosan-based adhesives | \nBioadhesives, antibacterial, haemostatics, wound-closing agents Pharmaceutical excipient: bioadhesives coating agents, disintegrants, film-forming agents, tablet binders | \n[64, 76, 78] | \n
Collagen-based adhesives | \nHaemostatics for general and vascular surgeries, retroperitoneal injuries, sealants (clot formation), wound dressing | \n[64] | \n
Chondroitin sulphate glue | \nBonds the native cartilage tissue, wound-closing agent Bonds implants, seals corneal incisions | \n[67, 79] | \n
Fibrin-based adhesives | \nHaemostatics, sealants (clot formation), wound-closing agents | \n[32, 80] | \n
Gelatine and gelatine-based products | \nHaemostatics in various surgical procedures and anatomical sites (clot formation), sealants, adhesives | \n[64, 65] | \n
Hyaluronate sodium | \nBioadhesive, sealant Plastical surgery Pharmaceutical excipient: humectant, lubricant, matrix for sustained release | \n[81, 82, 83] | \n
Cyanoacrylates | \nTissue adhesives in surgical procedures: vascular surgery, urology, cosmetic surgery, skin graft fixation Fistula repair, closure of hernia incisions Endoscopic, laparoscopic and interventional radiology procedures Sealants in dentistry Disposable plastic medical devices Transdermal patches | \n[33, 69, 71, 84] | \n
Dendrimers | \nStudied as sealant agents in corneal incisions | \n[28, 67] | \n
PEG-based adhesives | \nSealants in gynaecologic and colorectal procedures Sealing of fluid leaks, acute aortic dissection, haemostasis in anastomotic bleeding wound closure Bone fixation, sealant for vascular graft, haemostatic, wound-closing agent | \n[67, 75, 79] | \n
Carbomer | \nBioadhesive Pharmaceutical excipient: release-modifying agent, tablet binder, viscosity-increasing agent, suspending agent, tablet binder | \n[37, 58] | \n
Polycarbophil | \nBioadhesive Pharmaceutical excipient: absorbent, controlled-release tablet binder, emulsifying agent, thickening agent, suspending agent | \n[58, 85] | \n
Polyethylene oxides and derivatives | \nBioadhesive, surgical tissue adhesive Pharmaceutical excipient: tablet binder, thickening agent | \n[58, 86] | \n
Poly(methyl vinyl ether/maleic anhydride) | \nBioadhesive Pharmaceutical excipient: colour dispersant, complexing agent, film former, emulsion stabiliser, viscosity-increasing agent | \n[58] | \n
Povidone | \nBioadhesive Pharmaceutical excipient: disintegrant, tablet binder | \n[58] | \n
Urethane-based | \nSealant, tissue adhesive Fixation of vascular graft and bone Cosmetic surgery Preventing seroma formation in abdominoplasty | \n[67, 87] | \n
Polar lipids: glyceryl monooleate | \nBioadhesive, pharmaceutical excipient Nano-vehicle for many active substances | \n[60, 61, 62] | \n
Nanoparticles (based on different components) | \nBioadhesives Antibacterial properties Wound-closing agents | \n[64, 87, 88] | \n
Marine mussel extract adhesives | \nBioadhesives, repairing gestational fatal membrane ruptures Islet transplantation at extrahepatic sites Prosthetic mesh fixation Some derivatives: haemostatic and wound-closing agents | \n[31, 33, 89] | \n
Gecko-inspired adhesives | \nWound sealing, suture and staple replacement Suture/staple replacement/supplements Waterproof sealant for hollow organ anastomoses and for prevention of air leaks in lung resection Haemostatic, wound dressing, mesh grafts (ulcers, hernias, burns) | \n[33, 64] | \n
When an adhesive comes in contact with a biological tissue, it is named ‘bioadhesive’. Bioadhesion is the capacity of a compound to adhere to the biologic substrate for a long time. When the biologic substrate is represented by a mucosa, the phenomenon is called mucoadhesion. The mucoadhesive materials interact with the glycoproteins in the mucus covering the epithelia of the mucosae. The generally accepted idea is that the mucoadhesion process involves several stages: wetting and swelling of the hydrophilic polymer which allows its contact with the biologic tissue and the interpenetration of the polymer chain with the molecules in the mucin, which leads to an adequate interpenetration of the substrate and creates a semipermanent adhesive bonding. Other theories explain the forces that underpin bioadhesion: van der Waals forces, hydrogen bondings, disulphide bridges, hydration forces, hydrophobic interactions, steric forces, covalent bonds, etc. [34, 35].
\nBioadhesive drug delivery systems are promising systems for delivery of numerous and various active substances, from common ones to prebiotics [36], herbal products [37] and proteins [38]. They present themselves as solids, semisolids and liquids (gels, films, tablets, etc.) in conventional formulations or as nanoparticulated systems, designed for various routes like oral route [39, 40], skin route [41, 42] or mucosal route (buccal [43], ocular [44], vaginal [45], nasal [46], oesophageal [47]). The use of nanoparticulate bioadhesive systems can substantially improve the absorption of the active substances while offering protection against certain factors. Moreover, nanoparticulate bioadhesive systems represent potential targeted protein delivery systems [48].
\nTesting of the mucoadhesion represents a very important objective during the development of bioadhesive systems for drug release, as it can reveal the compatibility with the other components of the system, their stability and the strength of the adhesion capacity. Most methods used for the control of the mucoadhesive capacity of drug systems cited in the literature are based on the measurement of the force required to the disruption of the adhesive bond between the model membrane and the adhesive material [49].
\nThe main excipients of a bioadhesive system are represented by bioadhesive polymers and their structural and functional characteristics having a decisive influence on the bioadhesion. These polymers are hydrophilic matrices consisting of a reticular network that swell in contact with water without being dissolved. The polymeric materials are available in a wide variety of molecular weights and compositions which adsorb the water, swell and generate a gel structure (hydrogel). These swollen gels act as a reservoir and ensure a prolonged release of the active substances dispersed in the meshes of the polymeric network. After swelling, a relaxation of the network chains takes place, and the incorporated drug substances are released through the spaces inside the network. The property to control the release rate of the biologically active substance, the bioadhesive performance and the nontoxic profile of the polymer are primordial criteria for the selection of a bioadhesive agent used in the designing of controlled drug release systems. The hydrogel-forming polymers used for the preparation of mucoadhesive systems are represented mainly by polyacrylates (Carbopol and polycarbophil), polyethylene oxide, polyvinyl alcohol, poly(
Different hydrogels can be combined together or with other components, obtaining derivatised polymers, with the purpose of improving their jellifying and adhesion properties [42, 53, 54, 55]. An innovative approach in the synthesis of hydrogels aims at the improvement of their mechanic properties. This can be achieved by grafting various functional groupings that allow self-assembling in aggregates or triblocks polymers (Poloxamers) that can change their consistency in the presence of certain stimuli (pH, temperature, etc.). Heat-sensitive polymers are of particular interest as drug vehicles, as they allow the preparation of formulations with a lower consistency and are easy to apply and develop a good contact in the presence of physiological medium, by forming in situ gels [47, 56, 57].
\nBesides their role as adhesives, bioadhesive polymers can also fulfil other functions in a pharmaceutical system: diluent, disintegrant, viscosity enhancer, etc. Their nature, quantity and association with other excipients highly influence the final drug product quality [58].
\nBioadhesive polymers are used in many medical devices and drug delivery systems, including transdermal patches. Transdermal patch technology is another application of biomedical adhesives, ensuring drug delivery to the bloodstream through the skin; this is a highly effective method of drug administration, as the drug is incorporated into a membrane (made of adhesive) that sticks the patch to the skin and controls the rate at which the drug is absorbed. These systems ensure that the drug is continuously administered throughout the day, avoiding the fluctuations of the plasmatic concentration, usually associated with orally administered drugs. The applications of patches include hormone replacement therapy, pain cessation, smoke cessation and treatment of various cardiovascular pathologies [30, 59].
\nAn alternative for polymeric materials with bioadhesive properties is polar lipids (e.g. glyceryl monooleate). Polar lipids are water-insoluble amphiphilic molecules that swell when in contact with water, associate and form various types of aggregates (spheric, hexagonal micelle, lamellar phase, cubic phase). The cubic crystalline phase has the aspect of a transparent, rigid, viscous gel with good mucoadhesive characteristics and can incorporate hydrophilic, amphiphilic as well as lipophilic drug substances. These bioadhesive properties make it an in situ forming biodegradable matrix, thus a potential nanostructured vehicle for prolonged drug release. Cubosomes represent a dispersion of the cubic crystalline phase (similar to liposomes which represent the dispersed lamellar crystalline phase). They are submicronic particles and present unique properties as they can incorporate drug substances with various polarities and molecular masses (rifampicin, carbamazepine, griseofulvin, coenzyme Q10, lycopene, phytosterols, sodium diclofenac, etc.). Some studies revealed that cubic-phase dispersions can maintain high plasma oligopeptide levels for several hours and favour insulin absorption through the nasal mucosa in rats. Moreover, cubosomes lower the rate of enzymatic degradation of the oligopeptides (insulin, somatostatin) and enzymes. Multiple possibilities of using cubosomes as drug vehicles for various routes of administration (oral, parenteral, cutaneous or mucosae: nasal, ophthalmic, vaginal, buccal, periodontal pocket) have been reported so far in literature [60, 61, 62, 63].
\nWound closure is a key step in the success of surgical procedures. Surgical adhesives represent a convenient method for wound closing, having several advantages: less pain, no suture removal, excellent cosmetic result, and localized drug release [64]. A tissue adhesive can be defined as any substance with characteristics that allow in situ polymerisation to cause adherence of tissue to tissue or tissue to non-tissue surfaces. Their applications include prostheses, bleeding control (haemostats) and serving as a barrier to gas and liquids (sealants) [65]. Many tissue adhesives and haemostats have been developed over the past 30 years, based on various materials. The existing models are not sufficient for an in-depth study of the attachment of adhesives to living tissues; therefore, the strength of the adhesive joint is determined experimentally, according to standard tests and under conditions that are close to a real surgical situation. A bioadhesive must exhibit distinct characteristics, depending on the targeted tissue [66]. The successful usage of a tissue adhesive depends on its specific indications/limitations, which need to be thoroughly analysed by surgeons in order to choose the best product [67].
\nThere are different commercially available tissue adhesives: natural or biological, synthetic, semisynthetic and biomimetic. The biomimetic action of adhesives is based on algae’s abilities to wet a surface and the gecko’s ability to ‘adhere’ on to surfaces. Surgical adhesives and sealants based on natural polymers offer a more biocompatible alternative to synthetic glues. The composition of a new bioadhesive material from fish parasite
Dental adhesives are intended to provide retention to composite fillings or composite cements. They can be defined as solutions of resin monomers (with both hydrophilic and hydrophobic groups) that make the resin-dental substrate interaction possible. Some of them are also used for their protective effect against enamel erosion. The failure of restorations occurs more often due to the inadequate sealing, with subsequent discoloration of the cavity margins, rather than loss of retention. Recent development of dental adhesives has greatly simplified the application procedure, as opposed to classical bonding agents (multistep systems), with the purpose of reducing technique sensitivity and manipulation time [69, 70, 71, 72, 73, 74].
\nWhile older generation of mucoadhesive polymers lacks specificity and targeting capability, newer polymers—falling into the second generation of mucoadhesives—can form covalent bonds with the mucus and the underlying cell layers, thus exhibiting improved chemical interactions and offering new possibilities for more specific drug-receptor interactions. Examples of such new-generation adhesives are thiolated and lectin-mediated mucoadhesive polymers [75].
\nAdhesives have been used in industry for decades; however, the environmental influence of adhesives has not been investigated up until recently. Therefore, one must emphasise on the necessity to develop steps that will allow obtaining environmentally safe and high-quality adhesives that best fit their applicability domains. Due to the limited raw materials (reserve of oil) and the negative impact of synthetic compounds on both human health and environment, natural and renewable resources represent an attractive alternative for the production of adhesives. One innovative alternative for synthetic reactive glues like cyanoacrylates is represented by gecko-inspired and marine-inspired bioadhesives (mussel proteins) or their combination; however, further research needs to be conducted in this direction. Taking into consideration the rapid development of bioadhesive market, more work needs to be done in both environmental and economic aspect.
\nAgriculture plays a vital role in the Myanmar economy and contributes around (20.9%) of the total GDP and is a source of employment for rural population of the country. The performance of agricultural sector has had large impact on the tendencies of Myanmar’s GDP. About 70% of the rural population employs in agricultural sector. Myanmar is a leading and second biggest producer of rice and pulses. Myanmar agriculture not only contributes food grains but also contributes mainly towards the exports. Myanmar has the largest area of agri-ecological land in Southeast Asia and is the largest exporter for beans and pulses in Asia and ranks second after Canada in the world [1]. The improvement in agriculture sector becomes thus important for the betterment of growth of the economy.
The fluctuation of Agricultural production mainly depends on climate change. The climate change is closely associated with food security and poverty of majority of population in the country which mainly depend on agricultural sector [2]. The climate change largely affects Myanmar agriculture and become a challenge for future agriculture production in Myanmar [3] due to the reason that Myanmar is one of the top ten nations prone to climate change and extreme events like drought [4] in central dry zone of Myanmar, consisting of three regions namely the lower Sagaing, Mandalay and Magyay Regions, occupying 13 percent of total land areas and 19 percent of total population of Myanmar [5]. The Central Dry Zone is a strategic area for the agriculture of the country as well as second leading rice producing region in which 22 percent of annual rice production provides for the requirement of the country. In the Central Dry Zone, Shwe Bo and Kyaut Se are the major rice producing areas where rice-based farming system is mainly adopted.
The Dry Zone is particularly at risk from floods and drought [6, 7] and has a serious water scarcity. As a result, Dry Zone becomes more vulnerable to the impact of climate change [8]. Coastal regions are also vulnerable to the impacts of rise in sea level and cyclones [6, 7]. Frequent extreme weather events have caused a decrease in productivity of agriculture and thereby leading to decrease in GDP and household income as well as a decrease in food security [9]. Agriculture and climate change are thus directly associated and have mutual effects. The climate change affects the agricultural production at both micro and macro scales [10].
This study attempts to examine the effect of climate change on agricultural production in Myanmar at macro scale. This study is divided into four parts: overview of Myanmar economy as part I, overview of climate change situation as part II, most common crops and production in Myanmar as part III, data source and empirical model as part IV and the effect of climate change on agricultural production in Myanmar as part V.
Myanmar’s economic sector can be grouped into agricultural sector, industrial sector and service sector. Agriculture, livestock and fisheries, forestry sectors are considered as Agriculture sector; mining, processing and manufacturing, energy, electrical power and construction sectors are regarded as Industrial sector and finally transportation, communication, fiancé, social and administration, rents and services and trade sectors are grouped as Services sector.
Many efforts were being made by the government in attaining economic growth throughout the country. The government has been formulating and implementing national and regional level economic plans as well as sectoral development plans, aiming to accelerate growth, and to achieve equitable and balanced development all over the country through Framework for Economic and Social Reform (FESR) and Myanmar sustainable Development Plan (MSDP). Moreover, more investment on manufacturing sector were made by the government through providing technical assistance and loans to Small and Medium Enterprises (SMEs), and facilitating vocational training programs to labor force.
The economic growth was significant in 2010, reflecting the growth rate of GDP had been rapidly increasing till 2014–2015. The average growth rate of GDP had decreased to 9.5 percent due to the impact of Cyclone Komen in 2015. The economic growth had fluctuated and just above 5 percent since 2012, due to the reasons that the fluctuation in agricultural production associated with climate change and climate-related natural disasters and lack of capacity to adopt climate change adaptation strategies in response to climate change [11, 12, 13]. Over the same period, the share of the industry and service sector had increasing trend while the share of agricultural GDP had decreasing trend over the period between 2000 and 2019.
GDP of the country during the period between 2009 and 2010 and 2018–2019 can be seen in Table 1. During the period between 2009 and 2010 and 2014–2015, the economic growth rate was seen as upward trend, indicating an increase in growth rate due to government encouragement of manufacturing sector through providing technical assistance and loans to Small and Medium Enterprises (SMEs), and facilitating vocational training programs to labor force. Starting from 2015 to 2016, the value of GDP had decreasing trend with 6.8 percent in 2018–2019 due to government encouragement on private sector in the service sectors as well as reduction in government budget on infrastructure for public sector projects. Though Myanmar economy still depends on agriculture sector, the share of agriculture in GDP is gradually decreasing with increasing share of industry and service in Gross Domestic Product.
Year | Agriculture | Industry | Service | GDP (Kyats Million) | Growth rate of GDP | |||
---|---|---|---|---|---|---|---|---|
Value (Kyat Million) | Percent | Value (Kyat Million) | Percent | Value (Kyat Million) | Percent | Value (Kyat Million) | Percent | |
2009–2010 | 15214305.5 | 30.2 | 19884328.3 | 39.5 | 15230298.2 | 30.3 | 50328932 | 5.7 |
2010–2011 | 15632203.6 | 30.3 | 20120658 | 39.0 | 15838569.3 | 30.7 | 51591431 | 5.9 |
2011–2012 | 16015275.5 | 29.1 | 22234265.6 | 40.2 | 16785769.9 | 30.5 | 55035311 | 6.7 |
2012–2013 | 16685355.3 | 27.9 | 24400089.5 | 40.8 | 18718696.1 | 31.3 | 59804141 | 8.7 |
2013–2014 | 17065701.6 | 26.1 | 26808190.3 | 41.0 | 21511938.1 | 32.9 | 65385830 | 9.3 |
2014–2015 | 18654719.7 | 25.3 | 30452170.9 | 41.3 | 24627179.4 | 33.4 | 73734070 | 12.8 |
2015–2016 | 19460590.9 | 24.1 | 33753224.1 | 41.8 | 27535524.9 | 34.1 | 80749340 | 9.5 |
2016–2017 | 20551566.4 | 23.2 | 37294006.3 | 42.1 | 30738765.3 | 34.7 | 88584338 | 9.7 |
2017–2018 | 20897983.7 | 22.1 | 40188430.1 | 42.5 | 33474598.2 | 35.4 | 94561012 | 6.7 |
2018–2019 | 21107523.6 | 20.9 | 43325969.4 | 42.9 | 36559442.8 | 36.2 | 100992936 | 6.8 |
Growth rate of gross domestic product and Sectoral contributions.
Source: Ministry of Planning and Finance (2020).
Myanmar has a tropical climate with three seasons: summer, rainy and winter. Summer season starts from March and April, rainy season starts from May to October, and winter season starts from November to February. Seasonal temperatures vary largely in most of the regions/state in the country. The Central Dry Zone is highest in temperature and lowest in mean annual precipitation (500–1,000 mm/year). The maximum temperature has 40–43°C in the hot/dry season to minimum temperature has 10–15°C in the cool/relatively dry season and decrease from 0°C to −1°C in the hilly. The Coastal region, south of the country does not vary in seasonal temperature [14].
The climate trend over last six decades are found as a rise in mean temperature by around 0.08°C each decade; overall rise in rainfall throughout the country; rise in sea level and more extreme weather events such as drought and flood; and the monsoon period become shorter with more intense rainfall [15]. Over last three decade (1981–2010), temperature increased 0.14°C and 0.35°C per decade in coastal and inland regions. During the period between 1981 and 2010, total annual precipitation increased by 157 mm per decade in coastal areas and by 37 mm per decade inland [3].
Between year 2000 to 2010, the climate trend over last decades can be seen as large variation in highest temperature with 1.158°C and lowest temperature with 0.162°C. After year 2010, temperature had been an increasing trend from lowest temperature with 0.467°C to highest temperature with 1.552 [16].
Extreme weather events like droughts and flood are the main cause of natural disaster in Myanmar. The average annual rainfall of Myanmar is about 1630 mm, with half of the country lying within the 1500–2000 mm. Flooding and land slide occurred due to high intensity rainfall in dry zone areas [17].
The new climate change projections for Myanmar reveals a 0.8–2.7°C increase in minimum temperature and a 0.8–2.6°C increase in maximum temperature by the end of 2100 under representative concentration pathway (RCP) 4.5. Under RCP 8.5, minimum and maximum temperatures will increase by 0.9–4.6°C and 0.8–4.4°C respectively. Precipitation is projected to rise by 36 percent under RCP 4.5 and 40 percent under RCP 8.5.
Other key features of probable change at country level consists of increasing temperature with more extreme hot days and more extreme rainfall, resulting in more droughts and floods; increasing risk of flooding as a result of higher average rainfall intensity in monsoon events; more variable rainfall in the rainy season across the country (but particularly in the north) from March to November and a decrease between December and February [18]; more frequent and more intense extreme weather events, including cyclones/strong winds, flood/storm surge, intense rains, extreme high temperatures, drought and sea level rise [19].
Myanmar mainly produce the most common crops such as rice, pulses and beans, and maize and other crops in four different zones: Delta zone, Coastal zone, Central dry zone, and hilly and mountainous zone. Rice is the main staple food crop, cultivating nearly 50% of Myanmar’s agricultural land [15]. The Ayeyarwady Delta Region contributes the largest share of production of rice while central dry zone contributes the highest share of pulses and beans. Among the most common crops, rice is normally grown during the monsoon season and pulses and beans are largely grown during the dry season. The Delta zone including Yangon, Bago, Ayeyarwaddy, and Mon state largely grow major crops such as rice, and pulses; Coastal zone including Tanintharyi Region, Mon State, Kayin State mainly grow rice, rubber, oil palm and fruit tree; Central dry zone including Magway, Mandalay largely grow rice for subsistence, oil cops, pulses, sesame, groundnuts, vegetables and tea; hilly and mountainous zone including Shan, Chin typically grow rice, wheat, maize, sorghum, vegetables, sugarcane, and coffee.
The total arable land increased from 9909 hectare in 2000 to 11080.3 hectare in 2018. Major export crops are rice and pulses. The country has a huge potential for agricultural development due to abundant in natural resources but has been facing some constraints such as providing irrigation and provision of infrastructures, insecure land titles, limited financial resources, provision of farm inputs and extension services, limited use of farm machinery and low investment in the development of its agricultural sector. The annual variation of crop production and yields is caused by seasonal nature of farming, climatic variations and extreme events [17]. The precipitation, temperature and humidity influence the types, production and yield of crops depending on different spatial location, indicating that different climate in different location affect production of crop [20].
The crop yield has found significant annual variation over the past decade due to different factors such as holding with insufficient land appropriate for diversification covering with an average lot size of 2.27 ha [15] largely relying on rainwater for irrigation, frequent flooding and drought stress. The paddy production and yield had increasing trend over the past decade but decreasing trend after year 2010 due to the reason that paddy plantations were damaged in 2015 by flood, accounting for 79 percent of total damage areas and 89 percent of the destroyed crops [21]. More than a million acres of cultivated land were adversely affected by heavy monsoon-related flood in 2018 as well as about 250,000 acres were destroyed especially paddy, maize, sesame, various beans and pulses (Myanmar Time 2018). The production and yield had been increasing in 2017–2018 due to favorable weather and more provision of irrigated water to farmers [1, 16]. The 26.3 million tonnes of rice (paddy), 1.6 million tonnes of groundnut and 0.7 million tonnes of sesame seeds were produced under the crop land area of 110830.3 ha [16].
This study is based on country level data of Myanmar cereal crops for the time span of 2009 to 2019 obtained from various sources such as FAO STAT and Department of Agriculture and Department of Meteorology. The data are classified into two parts: cereal crop production and meteorological variables (temperature and precipitation). The data on cereal crop production are obtained from FAO STAT and meteorological variables are obtained from Statistical Yearbook with various issues. The data on agricultural inputs such as use of pesticides, application of fertilizers was obtained from FAO STAT. Climate variables such as annual precipitation and maximum and minimum temperature have been taken into in the model. State and district-wise Annual rainfall data for the respective years (2009–2019) has been obtained from Central Statistical Yearbook from the Ministry of Planning, Finance and Industry in Myanmar [22].
The relationship between climate change and agricultural production for the years 2009–2019 is analyzed with an econometrics model using Panel Regression. The data were collected for the country as a whole. Cereal crop production in kg per hectare is taken into consideration as Dependent variable while climate variable (average annual maximum and minimum temperatures, and average annual precipitation), agricultural inputs (application of fertilizer consumption, and phosphate and potash) are regarded as Explanatory variables.
This study is mainly used by multiple regression model. This regression analysis has been conducted using “R” to find out the best fit in the model. The “R” was used to analyze the data collected, and results is presented in table. Linear regression inferential statistic was used to analyze the contributions of the independent variables to the dependent. The statistical modeling applies observed country data on production of cereal crops and historical weather records to fit Linear regression functions in order to predict the response of cereal crop production [23, 24]. As a statistical model, Linear regression equation is used to link variations in historical year-to-year cereal crop production to variation in particular climate variables.
The functional form of the equation may be written as [25].
Where, TProd stands for total production for cereal crops. TEMP, RAIN, FC, Phosphate, Potash denotes annual temperature, rainfall, total fertilizer consumption, phosphate and potash respectively. Climate factors, fertilizers, phosphate and potash are assumed to be input factors for growth of production of cereal crops in multiple regression model.
The above equation can be written in the multiple regression form as:
Where, 𝛽0 is constant coefficient; 𝛽1, 𝛽2, 𝛽3, 𝛽4, and 𝛽5, are the coefficients for the respective variables and μs is the intercept term.
Change in crop production are very sensitive to climate change particularly in changes in temperature and changes in rainfall [26, 27]. Climate change significantly affects the crop production due to the fact that crop production largely depends on temperature and water [28, 29, 30]. Climate change may lessen the period of crop maturation and increase in variation of crop yield, decrease suitable areas for crop production [31, 32, 33] decrease in crop yield, [34, 35, 36] and thereby leading to reduce crop production [37, 38, 39].
The result can be seen in Table 2. According to the result, the coefficient for temperature is found a negative and 1% significant in production of cereal crops in Myanmar. Temperature negatively affects the crop production due to the fact that temperatures in Dry Zone could reach 40–43°C during the hot dry season. This indicates that an increase in temperature reflects a decrease in cereal crop production in Myanmar. This means that a 1°C increase in temperature in the growing period may decrease with production of cereal by 3849347 tons. It is found that an increase in temperature strongly influences on crop production and the temperature-related extreme weather events have an association with the production of cereal crops. The result is the same with the finding of Lesk et al. 2016 that drought and extreme temperature adversely affected on production of agriculture across the world and also greater impact on production of cereal crops [40]; and finding of You L et al. 2009 who found that in term of cereal crops, the higher temperature can negatively effect on cereal production, reflecting a 1°C increase in temperature in the growing period may decrease production of wheat by about 3–10% [41]. The result is also consistent with the finding of [42, 43] in which higher temperatures may have negative impact on aggregate output. An increase in temperature-related extreme weather events have an association with reduction in production of crops in Myanmar. Due to the reason, irrigation is largely demanded in order to cope with reduction in cereal crops production. To cope with this condition, water storage need to be reinforced in order to capture rain to reduce water needs in growing season.
Estimates | Std. Error | T value | P(>t) | |
---|---|---|---|---|
Intercept | 144749537 | 37469082 | 3.863 | 0.00479* |
Temperature | −3849347 | 1294063 | −2.975 | 0.01775** |
Rainfall | −5762 | 3095 | −1.862 | 0.09966 |
fertilizer | −148386 | 122053 | −1.216 | 0.25873 |
phosphate | −111175 | 449545 | −0.247 | 0.81090 |
potash | 63836 | 649849 | 0.098 | 0.92417 |
Multiple R-squared: | 0.7575 | |||
Adjusted R-squared: | 0.606 | |||
F-statistic: | 4.999 |
Regression result of climate change on cereal production.
1% significant.
5% significant.
The result found that the coefficient for rainfall are also negative but not significant with production of cereal crop production. This indicates that an increase in rainfall reflects a decrease in cereal crop production due to the fact that heavy intense of rain may cause frequent floods in Central Dry Zone that greatly affect the production of crop. Mean annual rainfall is generally the lowest in the Central Dry Zone (500–1000 mm per year) that is prone to extreme heat events and drought. In term of cereal crops, the intense rain can negatively affect on production of cereal crops, reflecting a 1 mm increase in rainfall in the growing period may decrease production of cereal by 5762 tons. Changes in rainfall affects delaying planting date which keeps crops at risk under the condition of high temperature in the growing season [44].
The result also found that the coefficient for fertilizer and phosphate are negative but not significant with production of cereal crops, indicating that an increase in utilization of fertilizer and phosphate reflects a decrease in production of cereal crops. This means that improper use of fertilizer negatively affects the production of cereal crop production. One-kilogram increase in consumption of fertilizer per hectare decreases with 148386 tons of cereal crop production and One-kilogram increase in consumption of phosphate per hectare decreases with 111175 tons of cereal production respectively. In order to improve production of cereal crop production, the social capital become urgently needed to incorporate and coordinate with respective stakeholders in order to adopt climate change adaptation measures such as stress tolerance crop varieties selection, enhancing drought resilience, drip irrigation technique for enhancing water use efficiency, sharing on climate resilient farming method among farmers, soil and water conservation, conservation and cultivation with local adaptable crop varieties in response to climate change. The same experience is found that the adoption of new technologies, such as drought-tolerant seeds, and changing farm practices, as sowing dates, are moderating the impacts of climate variability and change on crop yields [45, 46, 47].
The research found that an increase in temperature and rainfall negatively affects the production of cereal crops in Myanmar due to an increase in temperature that causes water stress in growing season due to reduction in moisture of soil and consequently reduction in cereal crop production [48, 49] and an increase in rainfall negatively affects the cereal crop production due to intense rainfall.
As a micro level, the farmers can adapt the effect of reduction in crop production by crop diversification as a farm-level response and/or non-farm income sources. So that farmers can have benefits with optimal utilization of their marginal land, and reduction in extreme climate risks and events and improving resilience in smallholder farming systems [50, 51, 52, 53]. In order to stabilize and increase farm income of the smallholder farmers, essential requirement is to encourage crop diversification by the government that generates raising farm incomes of smallholder farmers [54, 55, 56]. The relevant stakeholders need to provide knowledge and awareness for systematic utilization of farm inputs such as fertilizer and pesticide.
At the macro level, it is imperative for Myanmar to diversity its economy. Government needs to paid attention on integrated farming system that can generate employment opportunities and increase total income for farmers in order to response to climate change risk. Government need to pursue economic diversification strategies including expanding in climate sensitive sectors such as agriculture, fishery, forestry and energy and tourism that increase resilient in response to climate change. These sectors can provide employment opportunities and generate total incomes for long-term adaptation strategies. Government need to build capacity building program for all stakeholders including extension agents and farmers in order to be expertise in their farming operation thereby leading to manage reduction in crops caused by climate change.
Thus, policies aiming to enhance production of cereal crops should focus on adoption of climate change adaptation measures in Myanmar. Social networking between farmers and extension agents should be enhanced for natural resource management and adoption of climate change adaptation measures. On the other hand, policies targeting to increase cereal crop production should also proceed by scaling up programs. Government need to promote climate change adaptation measures such as drought resistant high yield varieties seeds; provide fertilizer and pesticide and skilled extension agents and services. Irrigation need to be sufficiently provided in order to improve the production of cereal crops. This indicates that water resource management become urgent need in Myanmar in order to capture rain and to reduce water scarcity in summer. Seasonal water shortage should be coped with water resource management and thereby leading to more efficient utilization of water resource [57] and improvement in crop production can be achieved. In sum, diversification become play a vital role for increasing resilience within the sector for sustainable development and thereby providing country to employment opportunities and income which in turn leads to reduction in poverty in the long run.
Firstly, I would like to my deepest gratitude to Intech Open for giving me an opportunity to write and submit my paper. I would like to my great gratitude to all academic editors for chapter review for my paper. I also owe a great thanks to my parents.
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This chapter dwells on the sources and reactivity of phenolic compounds in water, their toxic effects on humans, and methods of their removal from water. Specific emphasis is placed on the techniques of their removal from water with attention on both conventional and advanced methods. Among these methods are ozonation, adsorption, extraction, photocatalytic degradation, biological, electro‐Fenton, adsorption and ion exchange and membrane‐based separation.",book:{id:"6029",slug:"phenolic-compounds-natural-sources-importance-and-applications",title:"Phenolic Compounds",fullTitle:"Phenolic Compounds - Natural Sources, Importance and Applications"},signatures:"William W. Anku, Messai A. Mamo and Penny P. Govender",authors:[{id:"195237",title:"Dr.",name:"Messai",middleName:"A.",surname:"Mamo",slug:"messai-mamo",fullName:"Messai Mamo"},{id:"196465",title:"Dr.",name:"William Wilson",middleName:null,surname:"Anku",slug:"william-wilson-anku",fullName:"William Wilson Anku"},{id:"196466",title:"Dr.",name:"Penny",middleName:null,surname:"Govender",slug:"penny-govender",fullName:"Penny Govender"}]},{id:"36184",doi:"10.5772/36186",title:"Infrared Spectroscopy in the Analysis of Building and Construction Materials",slug:"infrared-spectroscopy-of-cementitious-materials",totalDownloads:7789,totalCrossrefCites:75,totalDimensionsCites:150,abstract:null,book:{id:"1591",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",title:"Infrared Spectroscopy",fullTitle:"Infrared Spectroscopy - Materials Science, Engineering and Technology"},signatures:"Lucia Fernández-Carrasco, D. Torrens-Martín, L.M. Morales and Sagrario Martínez-Ramírez",authors:[{id:"107401",title:"Dr.",name:"Lucia J",middleName:null,surname:"Fernández",slug:"lucia-j-fernandez",fullName:"Lucia J Fernández"}]},{id:"53128",doi:"10.5772/66368",title:"Phenolic Compounds: Functional Properties, Impact of Processing and Bioavailability",slug:"phenolic-compounds-functional-properties-impact-of-processing-and-bioavailability",totalDownloads:9304,totalCrossrefCites:75,totalDimensionsCites:141,abstract:"In this chapter, we discuss the influence of the processing methods on the content of phenolic compounds in fruits and vegetables. The intake of fruits and vegetables based‐foods are associated with delayed aging and a decreased risk of chronic disease development. Fruits and vegetables can be consumed in natura, but the highest amounts are ingested after some processing methods, such as cooking procedures or sanitizing methods. These methods are directly methods are directly related to alteration on the phenolic content. In addition, the postharvest conditions may modify several phytochemical substances. Phenolic compounds are referred to as phytochemicals found in a large number of foods and beverages. The relative high diversity of these molecules produced by plants must be taken into account when methods of preparation are employed to obtain industrial or homemade products. Phenolic compounds comprise one (phenolic acids) or more (polyphenols) aromatic rings with attached hydroxyl groups in their structures. Their antioxidant capacities are related to these hydroxyl groups and phenolic rings. Despite the antioxidant activity, they have many other beneficial effects on human health. However, before attributing health benefits to these compounds, absorption, distribution, and metabolism of each phenolic compound in the body are important points that should be considered.",book:{id:"5609",slug:"phenolic-compounds-biological-activity",title:"Phenolic Compounds",fullTitle:"Phenolic Compounds - Biological Activity"},signatures:"Igor Otavio Minatel, Cristine Vanz Borges, Maria Izabela Ferreira,\nHector Alonzo Gomez Gomez, Chung-Yen Oliver Chen and\nGiuseppina Pace Pereira Lima",authors:[{id:"146379",title:"Dr.",name:"Giuseppina",middleName:null,surname:"Lima",slug:"giuseppina-lima",fullName:"Giuseppina Lima"},{id:"194002",title:"MSc.",name:"Cristine",middleName:null,surname:"Vanz Borges",slug:"cristine-vanz-borges",fullName:"Cristine Vanz Borges"},{id:"194003",title:"Prof.",name:"Igor Otavio",middleName:null,surname:"Minatel",slug:"igor-otavio-minatel",fullName:"Igor Otavio Minatel"},{id:"194004",title:"Dr.",name:"Maria Izabela",middleName:null,surname:"Ferreira",slug:"maria-izabela-ferreira",fullName:"Maria Izabela Ferreira"},{id:"194005",title:"Prof.",name:"Hector",middleName:null,surname:"Gomez-Gomez",slug:"hector-gomez-gomez",fullName:"Hector Gomez-Gomez"},{id:"194006",title:"Prof.",name:"Chung-Yen Oliver",middleName:null,surname:"Chen",slug:"chung-yen-oliver-chen",fullName:"Chung-Yen Oliver Chen"}]}],mostDownloadedChaptersLast30Days:[{id:"55500",title:"Interpretation of Mass Spectra",slug:"interpretation-of-mass-spectra",totalDownloads:12367,totalCrossrefCites:10,totalDimensionsCites:23,abstract:"The chapter includes an introduction to the main ionisation techniques in mass spectrometry and the way the resulting fragments can be analysed. First, the fundamental notions of mass spectrometry are explained, so that the reader can easily cover this chapter (graphs, main pick, molecular ion, illogical pick, nitrogen rule, etc.). Isotopic percentage and nominal mass calculation are also explained along with fragmentation mechanism. A paragraph emphasises the ionisation energy issues, the basics of ionisation voltage, the developing potential and the energy balance. A frame time of the main theoretical milestones in both theory and experimental mass spectrometry is highlighted here. In the second part of the chapter, the molecular fragmentation for alkanes, iso-alkanes, cycloalkanes, halogen, alcohols, phenols, ethers, carbonyl compounds, carboxylic acids and functional derivatives, nitrogen compounds (amines, nitro compounds), sulphur compounds, heterocycles and biomolecules (amino acids, steroids, triglycerides) is explained. Fragmentation schemes are followed by the simplified spectra, which help the understanding of such complex phenomena. At the end of the chapter, acquisition of mass spectrum is discussed. The chapter presented here is an introduction to mass spectrometry, which, we think, helps the understanding of the mechanism of fragmentation corroborating spectral data and molecular structures.",book:{id:"5735",slug:"mass-spectrometry",title:"Mass Spectrometry",fullTitle:"Mass Spectrometry"},signatures:"Teodor Octavian Nicolescu",authors:[{id:"196775",title:"Dr.",name:"Teodor Octavian",middleName:"Octavian",surname:"Nicolescu",slug:"teodor-octavian-nicolescu",fullName:"Teodor Octavian Nicolescu"}]},{id:"57909",title:"Validation of Analytical Methods",slug:"validation-of-analytical-methods",totalDownloads:6859,totalCrossrefCites:13,totalDimensionsCites:20,abstract:"Method validation is a key element in the establishment of reference methods and within the assessment of a laboratory’s competence in generating dependable analytical records. Validation has been placed within the context of the procedure, generating chemical data. Analytical method validation, thinking about the maximum relevant processes for checking the best parameters of analytical methods, using numerous relevant overall performance indicators inclusive of selectivity, specificity, accuracy, precision, linearity, range, limit of detection (LOD), limit of quantification (LOQ), ruggedness, and robustness are severely discussed in an effort to prevent their misguided utilization and ensure scientific correctness and consistency among publications.",book:{id:"6379",slug:"calibration-and-validation-of-analytical-methods-a-sampling-of-current-approaches",title:"Calibration and Validation of Analytical Methods",fullTitle:"Calibration and Validation of Analytical Methods - A Sampling of Current Approaches"},signatures:"Tentu Nageswara Rao",authors:[{id:"220824",title:"Dr.",name:"Tentu",middleName:null,surname:"Nageswara Rao",slug:"tentu-nageswara-rao",fullName:"Tentu Nageswara Rao"}]},{id:"55440",title:"Solubility Products and Solubility Concepts",slug:"solubility-products-and-solubility-concepts",totalDownloads:3005,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"The chapter refers to a general concept of solubility product Ksp of sparingly soluble hydroxides and different salts and calculation of solubility of some hydroxides, oxides, and different salts in aqueous media. A (criticized) conventional approach, based on stoichiometry of a reaction notation and the solubility product of a precipitate, is compared with the unconventional/correct approach based on charge and concentration balances and a detailed physicochemical knowledge on the system considered, and calculations realized according to generalized approach to electrolytic systems (GATES) principles. An indisputable advantage of the latter approach is proved in simulation of static or dynamic, two-phase nonredox or redox systems.",book:{id:"5891",slug:"descriptive-inorganic-chemistry-researches-of-metal-compounds",title:"Descriptive Inorganic Chemistry Researches of Metal Compounds",fullTitle:"Descriptive Inorganic Chemistry Researches of Metal Compounds"},signatures:"Anna Maria Michałowska-Kaczmarczyk, Aneta Spórna-Kucab and\nTadeusz Michałowski",authors:[{id:"35273",title:"Prof.",name:"Tadeusz",middleName:null,surname:"Michalowski",slug:"tadeusz-michalowski",fullName:"Tadeusz Michalowski"},{id:"203867",title:"Dr.",name:"Anna Maria",middleName:null,surname:"Michałowska-Kaczmarczyk",slug:"anna-maria-michalowska-kaczmarczyk",fullName:"Anna Maria Michałowska-Kaczmarczyk"},{id:"203868",title:"Dr.",name:"Aneta",middleName:null,surname:"Spórna-Kucab",slug:"aneta-sporna-kucab",fullName:"Aneta Spórna-Kucab"}]},{id:"62736",title:"Radioisotope: Applications, Effects, and Occupational Protection",slug:"radioisotope-applications-effects-and-occupational-protection",totalDownloads:4481,totalCrossrefCites:7,totalDimensionsCites:14,abstract:"This chapter presents a brief introduction to radioisotopes, sources and types of radiation, applications, effects, and occupational protection. The natural and artificial sources of radiations are discussed with special reference to natural radioactive decay series and artificial radioisotopes. Applications have played significant role in improving the quality of human life. The application of radioisotopes in tracing, radiography, food preservation and sterilization, eradication of insects and pests, medical diagnosis and therapy, and new variety of crops in agricultural field is briefly described. Radiation interacts with matter to produce excitation and ionization of an atom or molecule; as a result physical and biological effects are produced. These effects and mechanisms are discussed. The dosimetric quantities used in radiological protection are described. Radiological protections and the control of occupational and medical exposures are briefly described.",book:{id:"5903",slug:"principles-and-applications-in-nuclear-engineering-radiation-effects-thermal-hydraulics-radionuclide-migration-in-the-environment",title:"Principles and Applications in Nuclear Engineering",fullTitle:"Principles and Applications in Nuclear Engineering - Radiation Effects, Thermal Hydraulics, Radionuclide Migration in the Environment"},signatures:"Sannappa Jadiyappa",authors:[{id:"239626",title:"Dr.",name:null,middleName:null,surname:"Sannappa J.",slug:"sannappa-j.",fullName:"Sannappa J."}]},{id:"58596",title:"Linearity of Calibration Curves for Analytical Methods: A Review of Criteria for Assessment of Method Reliability",slug:"linearity-of-calibration-curves-for-analytical-methods-a-review-of-criteria-for-assessment-of-method",totalDownloads:7965,totalCrossrefCites:19,totalDimensionsCites:42,abstract:"Calibration curve is a regression model used to predict the unknown concentrations of analytes of interest based on the response of the instrument to the known standards. Some statistical analyses are required to choose the best model fitting to the experimental data and also evaluate the linearity and homoscedasticity of the calibration curve. Using an internal standard corrects for the loss of analyte during sample preparation and analysis provided that it is selected appropriately. After the best regression model is selected, the analytical method needs to be validated using quality control (QC) samples prepared and stored in the same temperature as intended for the study samples. Most of the international guidelines require that the parameters, including linearity, specificity, selectivity, accuracy, precision, lower limit of quantification (LLOQ), matrix effect and stability, be assessed during validation. Despite the highly regulated area, some challenges still exist regarding the validation of some analytical methods including methods when no analyte-free matrix is available.",book:{id:"6379",slug:"calibration-and-validation-of-analytical-methods-a-sampling-of-current-approaches",title:"Calibration and Validation of Analytical Methods",fullTitle:"Calibration and Validation of Analytical Methods - A Sampling of Current Approaches"},signatures:"Seyed Mojtaba Moosavi and Sussan Ghassabian",authors:[{id:"216099",title:"Dr.",name:"Sussan",middleName:null,surname:"Ghassabian",slug:"sussan-ghassabian",fullName:"Sussan Ghassabian"},{id:"216101",title:"Mr.",name:"Seyed Mojtaba",middleName:null,surname:"Moosavi",slug:"seyed-mojtaba-moosavi",fullName:"Seyed Mojtaba Moosavi"}]}],onlineFirstChaptersFilter:{topicId:"8",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82358",title:"Water Defluoridation Methods Applied in Rural Areas over the World",slug:"water-defluoridation-methods-applied-in-rural-areas-over-the-world",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105102",abstract:"Overexposure to fluoride (F) through drinking water is the most widespread water problem in the world, but it has now exacerbated due to rapid population growth rates, adverse climatic changes, and increasing levels of water scarcity. Thus, despite the large amounts of data, which has accrued on mitigation methods of high F is still the primary impediment to drinking water programs among many developing nations. The current review chapter on F mitigation techniques applied world-over is aimed at providing a succinct overview of water defluoridation techniques and strategies being used to combat the impact of human F overexposure. It represents a starting point to understand the prospects of reducing the global F impact. It is anticipated that this work will lay a strong foundation for this and also inform strategies for safeguarding public health and the environment from F pollution.",book:{id:"11209",title:"Fluoride",coverURL:"https://cdn.intechopen.com/books/images_new/11209.jpg"},signatures:"Enos Wamalwa Wambu, Franco Frau, Revocatus Machunda, Lilliane Pasape, Stephen S. Barasa and Giorgio Ghiglieri"},{id:"82221",title:"Solvent Catalysis in the Sensitizer-Mediator Redox Kinetics",slug:"solvent-catalysis-in-the-sensitizer-mediator-redox-kinetics",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105393",abstract:"The sensitizer-mediator redox reaction is a vital component of the dye-sensitized solar cells (DSSCs). The efficiency and stability of dye-sensitized solar cells are aided by the kinetics of this redox process. Several reaction parameters influence the kinetics of a reaction, and if those parameters are controlled, the rate of the process and its results can be controlled. One of the most important aspects of the sensitizer-mediator interaction is the reaction medium. Aqueous DSSCs are unquestionably a good replacement when it comes to taking a green approach to avoiding toxic, flammable, and volatile organic solvents and their mixtures, which are commonly used in DSSCs and are known to harm the environment while also reducing the lifetime and stability of the DSSCs. The catalytic role of a small volume fraction of organic solvent in the aqueous electron transfer kinetics of a few putative sensitizer-mediator reactions is discussed in this chapter. In binary solvent media including dilute tertiary butyl alcohol (TBA)-water and dilute 1,4-dioxane-water, the reduction of dicyanobis(2,2′-dipyridyl)iron(III) and dicyanobis(1,10-phenanthroline)iron(III) was investigated. The reactions were carried out in a 10% TBA or dioxane to water media with a volume-volume fraction of both solvents using iodide as a reducing agent. The effect of several parameters on the rate constant was also calculated and analyzed.",book:{id:"11217",title:"Recent Advances in Chemical Kinetics",coverURL:"https://cdn.intechopen.com/books/images_new/11217.jpg"},signatures:"Rozina Khattak"},{id:"82282",title:"Pyridine Nucleus as a Directing Group for Metal-Based C–H Bond Activation",slug:"pyridine-nucleus-as-a-directing-group-for-metal-based-c-h-bond-activation",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.105544",abstract:"Carbon-hydrogen (C–H) bond activation involves a methodology for the construction of carbon-X (C–X) bonds where X can be carbon (C), oxygen (O), or the nitrogen (N), allowing the formation of C–C, C–O, or C–N bonds. Among them, the construction of the C–C bond within the aromatic moiety has remained a bottleneck because the abundance of C–H bonds in aromatic molecules possesses almost similar bond dissociation energies comparable to the C–C bond allowing leading to the poor reactivity and selectivity. Secondly, C–H bonds possess low polarity and thus confer them inertness. Considering this, directing group strategy came into existence, where the coordination ability of the heteroatoms such as O and N atoms within the ring was utilized for the direction of the reaction. The use of the heteroatom for the regioselective C–H bond activation is quite advantageous that could be explored immensely for their functionalization. In this chapter, we have congregated the information and put forth the evidence of C–H activation leading to the C–C bond formation in pyridine and pyridine-containing entities.",book:{id:"11562",title:"Chemistry with Pyridine Derivatives",coverURL:"https://cdn.intechopen.com/books/images_new/11562.jpg"},signatures:"Purohit Priyank, Joshi Gaurav and Aggarwal Meenu"},{id:"82236",title:"Alternatives to Soluble Phosphorus Fertilizers in Indian Context",slug:"alternatives-to-soluble-phosphorus-fertilizers-in-indian-context",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105561",abstract:"Phosphorus is one of the primary nutrients required in crop production. Rock phosphate is the raw material required for the manufacturing of soluble phosphorus fertilizers, which is nonrenewable in nature and expected to last for 50–400 years. The restriction of resources to few geographical locations makes its supply more vulnerable. In India, 90% of the rock phosphate for fertilizer manufacturing is imported. However, the low quality of rock phosphate deposits available in India can be utilized with certain modifications in the form of addition of phosphate-solubilizing bacteria, addition of gypsum, and in the form of phospho-enriched compost. Agriculture, livestock, urban and industrial waste can also prove to be a source of phosphorus through crystallization of struvite. There are encouraging results of struvite compared with soluble phosphorus fertilizers. This will reduce the import dependency in India as well as encourage the Atmanirbhar initiative in phosphorus fertilizer.",book:{id:"11906",title:"Phosphate Minerals",coverURL:"https://cdn.intechopen.com/books/images_new/11906.jpg"},signatures:"Alok Singh Jayara, Rajeew Kumar, Priyanka Pandey, Manoj Kumar Bhatt, Sharad Pandey and Roshan Lal Meena"},{id:"82251",title:"Potassium Persulfate as an Eco-Friendly Oxidant for Oxidative Transformations",slug:"potassium-persulfate-as-an-eco-friendly-oxidant-for-oxidative-transformations",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.104715",abstract:"The formation of carbon-carbon/carbon-heteroatom bonds by oxidative transformations is a hotly debated topic in chemistry. K2S2O8 has emerged as a cost-effective inorganic oxidant for a wide range of oxidative reactions in this setting. This book chapter covers oxidative reactions facilitated by K2S2O8 in the absence of a metal catalyst in detail. Organic chemists may find this book chapter valuable in formulating the mechanistic pathways involving the sulphate radical anion, as well as in the quick and environmentally friendly synthesis of novel chemical species.",book:{id:"11211",title:"Green Chemistry - New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11211.jpg"},signatures:"Bilal Ahmad Mir and Suresh Rajamanickam"},{id:"82242",title:"Monitoring Brain Activities Using fNIRS to Avoid Stroke",slug:"monitoring-brain-activities-using-fnirs-to-avoid-stroke",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105461",abstract:"Functional near-infrared spectroscopy (fNIRS) is an emerging wearable neuroimaging technique based on monitoring the hemodynamics of brain activity. First, the operation principle of fNIRS is described. This includes introducing the absorption spectra of the targeted molecule: the oxygenated and deoxygenated hemoglobin. Then, the optical path formed by emitters and detectors and the concentration of the molecules is determined using Beer-Lambert law. In the second part, the advantages of applying fNIRS are compared with other neuroimaging techniques, such as computed tomography and magnetic resonance imaging. The compared parameters include time and spatial resolution, immobility, etc. Next, the evolution of the fNIRS devices is shown. It includes the commercially available systems and the others under construction in academia. In the last section, the applications of fNIRS to avoid stroke are presented. The challenges of achieving good signal quality and high user comfort monitoring on stroke patients are discussed. Due to the wearable, user-friendly, and accessibility characteristics of fNIRS, it has the potential to be a complementary technique for real-time bedside monitoring of stroke patients. A stroke risk prediction system can be implemented to avoid stroke by combining the recorded fNIRS signals, routinely monitored physiological parameters, electronic health records, and machine learning models.",book:{id:"11564",title:"Infrared Spectroscopy - Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11564.jpg"},signatures:"Yun-Hsuan Chen and Mohamad Sawan"}],onlineFirstChaptersTotal:76},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:16,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:4,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"3",title:"Dentistry",doi:"10.5772/intechopen.71199",issn:"2631-6218",scope:"\r\n\tThis book series will offer a comprehensive overview of recent research trends as well as clinical applications within different specialties of dentistry. 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",coverUrl:"https://cdn.intechopen.com/series/covers/3.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:8,editor:{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"1",title:"Oral Health",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",isOpenForSubmission:!0,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). 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Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. 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