\r\n\tFurthermore, during the preparation of high-quality dairy products, several physical, chemical, enzymatic, and microbial transformations take place. We will consciously focus on this interaction of different constituents of milk under different processing conditions for the development of the products.
",isbn:"978-1-83768-093-1",printIsbn:"978-1-83768-092-4",pdfIsbn:"978-1-83768-094-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"420e687768b56ca7b3238d77f63f1302",bookSignature:"Dr. Neelam Upadhyay",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12173.jpg",keywords:"Protein, Fat, Lactose, Carbohydrates, Milk Processing, Milk Products, Milk Constituents, Acid Coagulated, Enzyme Treated, Heat Treated, Dairy Products, Protocols of Manufacturing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 18th 2022",dateEndSecondStepPublish:"June 15th 2022",dateEndThirdStepPublish:"August 14th 2022",dateEndFourthStepPublish:"November 2nd 2022",dateEndFifthStepPublish:"January 1st 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"21 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Upadhyay has received many awards most notable being the Young Woman Scientist Award 2020 from the Agro-Environmental Development Society and the Best Poster Award 2021 from the National Conference on Moringa Food Conclave 2021. She is a dedicated researcher in food and dairy processing and has published many research articles and papers in both national and international journals and publications.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"269538",title:"Dr.",name:"Neelam",middleName:null,surname:"Upadhyay",slug:"neelam-upadhyay",fullName:"Neelam Upadhyay",profilePictureURL:"https://mts.intechopen.com/storage/users/269538/images/system/269538.jpg",biography:"BRIEF BIODATA\n1.\tName in full: Neelam Upadhyay \n2.\tDate & Place of Birth: 29th December, 1987 at Delhi\n3.\tField of specialization: Food Technology\n4.\tPresent Position/ Designation: Scientist- Senior Scale\n5.\tAddress:\t(a)\tOfficial:\tTel. No.:0184-2259258\n\t\t\t\tE-mail: \ticar.neelam@gmail.com; neelam.upadhyay@icar.gov.in \n\t\t\t\tAddress: \tLaboratory No. 146, Dairy Technology Division, ICAR- \n\t\t\t\t\t\tNational Dairy Research Institute, Karnal \n\t\t\t(b)\tResidential: Tel. No.: +91-9255772587\n\tAddress (Permanent): 41-D, MIG DDA Flats, Shivam Enclave, Delhi-110032\n6.\t(a) Academic career and (b) professional attainments\n(a) Examination\tClass/ Percentage\tYear of Passing\tSubjects Taken\tName of University / Board\nXth \t1st/83\n(415/500)\t2003\tMathematics, Social Science, Science, English, Hindi\tK.V., Mumbai (CBSE)\nXIIth\t1st/78.2 \n(391/500)\t2005\tPhysics, Mathematics, Chemistry, Biology, English\tK.V., Delhi (CBSE)\nB.A.Sc. (Hons.)\t1st/83.43 (2044/2450)\n(3rd position)\t2008\tFood Technology\tSRCASW, University of Delhi, Delhi\nM.Sc.\t1st/8.62\n(1st position)\t2010\tFood Science & Technology\tCCS Har. Agri. Uni., Hisar, Haryana\nTitle of Research:\tDevelopment of flavoured whey-soya milk beverage\nMajor Advisor:\tDr. R. S. Dabur (Professor and Head)\nPh.D.\t1st/8.0\n(1st position)\t2014\tDairy Chemistry\tNational Dairy Research Institute, Karnal, Haryana\nTitle of Research: \tDetection of vegetable oil and animal body fat adulteration in ghee using solvent fractionation technique\nMajor Advisor:\tDr. Darshan Lal (Principal Scientist and Ex-Head)\nDistinctions during Academics\nDegree\tDistinctions\nBachelor of Applied Science (Hons.)\ti.\tY.K. Kapoor Memorial Scholarship 2006 by All India Food Processor’s Association \nii.\t3rd position in university\niii.\tReceived highest attendance award\niv.\tReceived trophy for ‘Most Disciplined Student’ for the graduation period 2005-2008\nv.\tCertificate of Honor from Honb’le Mr. Justice K.G. Balakrishnan, Chief Justice of India\nMaster of Science\ti.\t1st position in discipline and 2nd position in college\nii.\tReceived recognition for academic excellence from Jawaharlal Nehru Memorial Fund; \niii.\tQualified GATE\niv.\t2nd in inter-college yoga competition\nv.\tParticipated in various events of All India Youth Festival organized at UAS, Bangalore.\nDoctor of Philosophy\ti.\tReceived Merit Certificate for Academic Excellence in PhD course work\nii.\tReceived Certificate of Appreciation for outstanding work in the field of Dairy Processing during PhD\niii.\tQualified ICAR’s National Eligibility Test in 2010; Qualified the ICAR’s All India Examination, ICAR-SRF (PGS_-2011-2012 for award of ICAR-SRF (PGS) with 2nd rank (both in first attempt) \niv.\tQualified Agricultural Research Service Examination-2013 conducted by Agricultural Scientist Recruitment Board against the single vacancy (for UR) in the discipline of Food Technology\nv.\tStage Management Secretary of student’s council 2010-11\nvi.\tLiterary secretary of Student’s Council 2011-12\nvii.\tCompleted certificate e-course on “Publishing a Journal Manuscript - the Groundwork” directed by Springer in 2013\nviii.\tHave successfully completed certificate e-course – “Peer Review Academy” directed by Springer in 2013\nix.\tReceived a certificate on accomplishment IRIS 4-2 Information Literacy Plagiarism Quiz (on-line) in 2013 developed by Distance Learning Council of Washington, USA \n (b) Position Held\tInstitution \tPeriod of Appointment\tNature of Appointment\nScientist (Food Technology)\tICAR- National Academy of Agricultural Research Management, Hyderabad\t3 months\n(1st January, 2015 till 31st March, 2015)\tPermanent\n(Received ‘A’ grade for FOCARS)\nScientist \n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t10th March, 2015 till 31st December, 2018\n(after availing 10 days of transfer period)\tPermanent\nScientist-Senior Scale\n(Food Technology)\tICAR- National Dairy Research Institute, Karnal\t1st January, 2019 till date\tPermanent\n\n7. Special attainments in Research\n(https://scholar.google.co.in/citations?hl=en&user=PRz0Tz4AAAAJ&view_op=list_works&sortby=pubdate)\nPublications\tNumbers\tRemarks \nResearch Articles\t35\n(24 Intl, 9 National, 2 others)\tTotal Impact: 72.302\n\nBook Chapters\t7\t5 APA/CRC Press; 1 InTech Open; \n1 National\nReview Articles\t2\tTotal Impact:8.327\nTechnical Articles\t7\tCompendium of trainings, seminars, etc\nInstitute publication\t1\t\nPopular Article\t12\t6 in English; 5 in hindi\nCitations \t1066\t(as per googlescholar)\nH-index/ i10-index\t15/ 17\t\n.\n.\nJournal\tNumber of publications\tImpact factor\nResearch Articles\t35\t72.302\nInternational\t24 (15 as either corresponding or first author)\t72.302\nNational\t9 (3 as first or corresponding author)\tNAAS score\nOthers\t2\t\nReview article (International)\t2\t8.327\nInternational\t2\t8.327\n.\n \n\n\n\nRESEARCH ARTICLES\nInternational Journals \n1.\tTiwari, S., Upadhyay, N.*, Singh, A. K. (2022). Stability assessment of emulsion of carotenoids extracted from carrot bio-waste in flaxseed oil and its application in food model system. Food Bioscience, 47, 101631. https://doi.org/10.1016/j.fbio.2022.101631.\n2.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Singh, A. K., & Borad, S. G. (2021). Buffalo milk protein concentrate 60: Effect of skim milk heat treatment on its reconstitutability and functionality. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 148, 111638. \n3.\tUttamrao, H. J., Meena, G. S., Khetra, Y., Upadhyay, N., Singh, A. K., Arora, S., & Borad, S. G. (2022). Homogenization and sodium hydrogen phosphate induced effect on physical and rheological properties of ultrafilterd concentrated milk. Journal of Food Science and Technology, 59(3), 956-967. \n4.\tTiwari, S., Upadhyay, N.*, Malhotra, R. (2021). Three way ANOVA for emulsion of carotenoids extracted in flaxseed oil from carrot bio-waste. Waste Management, 121, 67-76. \n5.\tRanvir, S., Sharma, R., Gandhi, K., Upadhyay, N., Mann, B. (2020). Assessment of proteolysis in ultra-high temperature milk using attenuated total reflectance–Fourier transform infrared spectroscopy. International Journal of Dairy Technology. 73(2): 366-375. doi: 10.1111/1471-0307.12683. \n6.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). High performance liquid chromatographic (HPLC) determination of available lysine in milk protein-maize composite extrudates and its stability during storage. Journal of the Indian Chemical Society, 97(11a), 2344-2350\n7.\tTiwari, S., Upadhyay, N.*, Singh, A. K., Meena, G. S., & Arora, S. (2019). Organic solvent-free extraction of carotenoids from carrot bio-waste and its physico-chemical properties. Journal of Food Science and Technology, 1-10. 10.1007/s13197-019-03920-5\n8.\tBaria, B., Upadhyay, N.*, Singh, A. K., & Malhotra, R. K. (2019). Optimization of ‘green’extraction of carotenoids from mango pulp using split plot design and its characterization. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 104, 186-194. \n9.\tPatil, A. T., Meena, G. S., Upadhyay, N., Khetra, Y., Borad, S. G., & Singh, A. K. (2019). Effect of change in pH, heat treatment and diafiltration on properties of medium protein buffalo milk protein concentrate. Journal of Food Science and Technology, 56(3), 1462-1472. \n10.\tUttamrao, H. J., Meena, G. S., Borad, S. G., Punjaram, S. A., Khetra, Y., Upadhyay, N., & Singh, A. K. (2019). Effect of disodium phosphate and homogenization on physico-chemical and rheological properties of buffalo skim milk based ultrafiltered retentate. Journal of food science and technology, 56(5), 2426-2435. \n11.\tMeena, G.S., Dewan, A., Upadhyay, N., Barapatre, R., Kumar, N., Singh, A.K., & Rana, J.S. (2019). Fuzzy Analysis of Sensory Attributes of Gluten Free Pasta Prepared From Brown Rice, Amaranth, Flaxseed Flours and Whey Protein Concentrates. Journal of Food Science and Nutrition Research, 2(1), 022-037. DOI: 10.26502/jfsnr.2642-1100006\n12.\tPatil, A. T., Meena, G. S., Upadhyay, N.*, Khetra, Y., Borad, S., & Singh, A. K. (2018). Production and characterization of milk protein concentrates 60 (MPC60) from buffalo milk. Food Science & Technology – Lebensmittel -Wissenschaft & Tech, 91, 368-374. https://doi.org/10.1016/j.lwt.2018.01.028 \n13.\tUpadhyay, N.*, Jaiswal, P., & Jha, S. N. (2018). Application of attenuated total reflectance Fourier Transform Infrared spectroscopy (ATR–FTIR) in MIR range coupled with chemometrics for detection of pig body fat in pure ghee (heat clarified milk fat). Journal of Molecular Structure, 1153, 275-281. \n14.\tUpadhyay, N.*, Kumar A., Goyal A. and Lal, D. (2017). Complete liquification time test coupled with solvent fractionation technique to detect adulteration of foreign fats in ghee (heat-clarified milk fat). International Journal of Dairy Technology. 70(1): 110-118. doi: 10.1111/1471-0307.12323. \n15.\tUpadhyay, N.*, Goyal A., Kumar A. and Lal, D. (2017). Detection of adulteration of caprine body fat and mixture of caprine body fat and groundnut oil in bovine and buffalo ghee using Differential Scanning Calorimetry. International Journal of Dairy Technology. 70(2): 297-303. May 2017.doi:10.1111/1471-0307.12336. \n16.\tKumar, A., Upadhyay, N.*, Ghai, D.L., Kumar, A. Gandhi, K. and Sharma, V. (2016). Effect of preparation and storage of khoa on physico-chemical properties of milk fat. International Journal of Dairy Technology. 69(2): 294-300. doi: 10.1111/1471-0307.12266. \n17.\tUpadhyay, N.*, Jaiswal, P. & Jha, S.N. (2016). Detection of goat body fat adulteration in pure ghee using ATR-FTIR spectroscopy coupled with chemometric strategy. Journal of Food Science and Technology. 53 (10): 3752-3760. doi:10.1007/s13197-016-2353-2 ISSN 0022-1155\n18.\tRathi, M., Upadhyay, N.*, Dabur, R.S. and Goyal A. (2015). Formulation and physic-chemical analysis of whey –soymilk dahi. Journal of Food Science and Technology. 52(2): 968-975. doi 10.1007/s13197-013-1074-z. ISSN: 0022-1155. \n19.\tKanthale, P., Kumar, A. Upadhyay, N.*, Lal, D., Rathod G. and Sharma, V. (2015). Qualitative test for the detection of extraneous Thiocyanate in Milk. Journal of Food Science and Technology. 52(3): 1698-1704. DOI: 10.1007/s13197-013-1174-9. ISSN: 0022-1155.\n20.\tGoyal, A., Sharma, V., Upadhyay, N., Singh, A.K., Arora, S. and Ghai, D.L. (2015). Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids. Journal of Food Science and Technology. 52(7):4256-4265. \n21.\tUpadhyay, N.*, Kumar, A., Rathod, G., Goyal, A. and Lal, D. (2015). Development of a method employing reversed-phase thin-layer chromatography for establishing milk fat purity with respect to adulteration with vegetable oils. International Journal of Dairy Technology. 68(2): 207-217. doi. 10.1111/1471-0307.12178. \n22.\tGoyal, A., Siddiqui, S. Upadhyay, N., Soni, J. (2014). Effects of ultraviolet irradiation, pulsed electric field, hot water and ethanol vapours treatment on functional properties of mung bean sprouts. Journal of Food Science and Technology. 51(4): 708-714. doi 10.1007/s13197-011-0538-2. Publisher Springer. ISSN (electronic version): 0975-8402. \n23.\tKundu, H., Grewal, R.B., Goyal, A., Upadhyay, N.*, and Prakash S. (2014). Effect of incorporation of pumpkin (Cucurbita moshchata) powder and guar gum on the rheological properties of wheat flour. Journal of Food Science and Technology. 51(10):2600-2607. DOI: 10.1007/s13197-012-0777-x. ISSN: 0022-1155. \n24.\tUpadhyay, N.*, Kumar, A., Goyal, A. and Lal, D. (2014). A planar chromatographic method to detect adulteration of vegetable oils in ghee. JPC-Journal of Planar Chromatography-Modern TLC. 27 (6): 431-437. DOI: 10.1556/JPC.27.2014.6.5 \nNational Journals\n1.\tPonbhagavathi, T. R., Singh, A. K., Raju, P. N., Upadhyay, N. (2021). Textural and Sensory Characteristics of Milk Protein-Maize Flour-based Extrudates. Journal of Agricultural Engineering, 58(2), 124-136. 10.52151/jae2021581.1740\n2.\tPonbhagavathi, T.R., Singh, A.K., Raju, P.N., Upadhyay, N. (2020). Effect of Rennet Casein and Whey Protein Concentrate on Extrusion Behavior of Maize Flour. Current Journal of Applied Science and Technology. 39(33), 16-27, Article no.CJAST.57830.\n3.\tUpadhyay, N.*, Kumar, A., Lal, D., Kant, R., & Goyal, A. (2018). Detection of groundnut oil and goat body fat adulteration in ghee using principal component analysis on fatty acid profile. Indian Journal of Dairy Science. 71(5):464-472. \n4.\tUpadhyay, N.*, Kumar, A., Gandhi, K., Goyal, A. and Lal, D. (2014). Standardization of solvent fractionation technique for detection of adulteration in ghee by enriching animal body fat and vegetable oil in different fractions. Indian Journal of Dairy Science. 67 (4):323-327.\n5.\tGandhi. K., Upadhyay, N., Aghav, A.D., Sharma, V., and Lal, D. (2014). Detection of adulteration of ghee (clarified milk fat) with palmolein and sheep body fat using Reichert-Meissl (RM) value coupled with solvent fractionation technique. Indian Journal of Dairy Science. 67(5): 387-393. Received Second Best Paper Award during 44th Dairy Industry Conference organized by ICAR-NDRI, Karnal and Indian Dairy Association from 18-20, February 2016.\n6.\tAghav, A.D., Gandhi, K., Upadhyay, N., Kumar, A. and Lal, D. (2014). A study on the physico-chemical changes occurring in the milk fat during preparation of Paneer. Indian Journal of Dairy Science. 67 (5): 398-404.\n7.\tKumar, A., Upadhyay, N., Gandhi, K., Lal, D. and Sharma, V. (2013). Detection of soybean oil and buffalo depot fat in ghee using Normal-Phase Thin Layer Chromatography. Indian Journal of Dairy Science. 66(4): 294-99. ISSN: 0019-5146.\n8.\tKumar, A., Upadhyay, N., Gandhi, K., Kumar, A., Lal, D. and Sharma, V. (2013). Reverse-Phase Thin Layer Chromatography of Unsaponifiable Matter of ghee for detecting adulteration with soybean oil and buffalo depot fat. Indian Journal of Dairy Science. 66(6): 496-501. ISSN: 0019-5146.\n9.\tUpadhyay, N.*, Dabur R.S. and Rathi, M. (2011). Development and Shelf life Study of Flavoured Whey-soya milk beverage. Indian Journal of Dairy Science. 64(2): 92-101. ISSN: 0019-5146.\nOther Journals\n1.\tDewan, A., Meena, G.S., Upadhyay, N., Barapatre, R. Singh, A.K., Rana, J.S. (2017). Formulation of non-Gluten Pasta from the Optimized levels of Dairy and Non-Dairy ingredients. Madridge Journal of Food Technology. 2(2): 92–98. \n2.\tGalmessa, U., Prasad, S., Kumaresan, A., Oberoi, P. S., Baithalu, R. K., Upadhyay, N., and Dang, A. K. (2015). Modulation of Milk Fatty acid profile milk yield and composition through supplementation of omega-3 fatty acid in transition cow’s diet. Journal of Science and Sustainable Development. 3(1): 25-38. ISSN: 2070-1748\nREVIEW ARTICLES\n1.\tUpadhyay, N.*, Goyal, A. Kumar, A., Lal, D. and Singh, D. (2014). Preservation of milk and milk products for analytical purposes: A review. Food Reviews International. 30(3):203-224. DOI 10.1080/87559129.2014.913292. ISSN: 1525-6103\n2.\tGoyal, A., Sharma, V., Upadhyay, N., Gill, S. and Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology. 51(9): 1633-1653. DOI 10.1007/s13197-013-1247-9. ISSN: 0975-8402. \nBOOK CHAPTERS\n1.\tKumari, L., Sharma, M., & Upadhyay, N. (2021). Three-Dimensional Printing of Food Products: Printing Techniques, Novel Applications, and Printable Food Materials. Handbook of Research on Food Processing and Preservation Technologies: Volume 3: Computer-Aided Food Processing and Quality Evaluation Techniques, 55. Boca Raton, CRC Press\n2.\tUpadhyay, N.*, Harshitha, C. G., Pathak, N. K., & Sharma, R. (2021). Fourier Transform Infrared (FTIR) Spectroscopy with Chemometrics: Evaluation of Food Quality and Safety. Handbook of Research on Food Processing and Preservation Technologies: Volume 5: Emerging Techniques for Food Processing, Quality, and Safety Assurance, 271.\n3.\tNagarajappa, V., Upadhyay, N., Chawla, R., Mishra, S.K., & Nath, S. (2019). Functional Properties of Milk Proteins. In: Engineering Practices for milk products- Dairyceuticals, Novel Technologies, and Quality (pp 3-26). Apple Academic Press.\n4.\tUpadhyay, N., Kumar, M. C. T., Sharma, H., Borad, S., & Singh, A. K. (2019). Pulse Electric Field Processing of Milk and Milk Products. In: Non-thermal Processing of Foods (pp.129-144). Boca Raton, CRC Press\n5.\tUpadhyay, N., Nagaraj, V., & Singh, A. K. (2019). Advances in Fractionation of Milk Lipids: Analysis and Applications of fractions In: Recent Technologies in Dairy Science (pp. 325-344). Today and Tomorrow’s Printers and Publishers.\n6.\tNagaraj, V., Upadhyay, N.*, Nath, B. S., & Singh, A. K. (2018). Advances in Fractionation and Analysis of Milk Carbohydrates. In Technological Approaches for Novel Applications in Dairy Processing (pp. 127-147). IntechOpen. http://dx.doi.org/10.5772/intechopen.76312\n7.\tUpadhyay, N.*, Veena, N., Borad, S., & Singh, A. K. (2017). Application of Natural Antioxidants in Dairy Foods. In Natural Antioxidants (pp. 281-318). London: Apple Academic Press.\nINSTITUTE PUBLICATION\n1.\tDr. T. K. Datta, Dr. Meena Malik and Dr. Neelam Upadhyay (2017). Foundation Programme for Freshers at ICAR-NDRI 2017.\nPOPULAR AND LEAD ARTICLES\n1.\tPatil, A. T., Meena, G. S., Upadhyay, N., & Singh, A.K. (2017). Milk protein concentrates- Their Applications. Indian Dairyman, 69(9), 44-48.\n2.\tUpadhyay, N.* and R.K. Malik (2015). Nutritive Value of Milk. In: In Touch, Heinz Nutrition Foundation of India. Volume 17, Number 2&3, 2-11. (Lead Article). \n3.\tGoyal, A., Sharma, V., Upadhyay, N., Sihag, M. and Kaushik, R. (2013). High Pressure Processing and its impact on milk proteins: A Review. Research and Reviews: Journal of Dairy Science and Technology. 2 (1): 1-9. ISSN: 2319-3409.\n4.\tKumar, A., Upadhyay, N., and Naagar, S. (2012). Allergenicity of Milk Proteins, and its Management. Indian Food Industry. 31 (5&6): 45-50. ISSN: 0972-2610.\n5.\tGoyal, A. and Upadhyay, N. (2012). Nuclear Magnetic Resonance Spectroscopy in Dairy Science. Indian Food Industry. 31(1): 39-45. ISSN: 0972-2610.\n6.\tUpadhyay, N.*, Goyal, A. and Rathod, G. (2011). Microwave Spectroscopy and its applications in online processing. Indian Food Industry. 30(5&6): 63-73. ISSN: 0972-2610.\n7.\tउपाध्याय, नी*. (२०१८) भारत में कुपोषण: स्थिति और इससे निपटने के लिए रणनीतियाँ. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. २४-२९. \n8.\tउपाध्याय, नी.*, सिंह, आ.कु., गांगुली, स., सबिखी, ल. (२०१८) खाध्य और डेयरी क्षेत्र मे महिला उद्यमिता: कारण, समस्याए एवम उपलब्ध मंच. दुग्ध—गंगा (आठवाँ अंक). अप्रैल-सितम्बर. ६४-६९.\n9.\tउपाध्याय, नी*. (२०१९) ek¡ dk nw/k % f'k'kqvksa ds ekufld] 'kkjhfjd ,oa lkekftd mRFkku gsrq ve`r. दुग्ध—गंगा (नवाँ अंक). अकटूबर –मार्च १०२-१०४.\n10.\tउपाध्याय, नी*, fç;k ;koys (२०१९) [kk| inkFkksaZ esa —f=e ds cnys çk—frd jax o.kZd ds mi;ksx dh vko';drk दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १०२-१०५.\n11.\tuhye mikè;k;, fuys'k dqekj ikBd (२०१९) d`f\"k] [kk| ,oa Ms;jh m|ksx ds Hkfo\"; eas lkSj ÅtkZ dk egRo दुग्ध—गंगा (दसवाँ अंक). अकटूबर –मार्च १२६-१३०. \n12.\tवैज्ञानिक और तकनीकी विषय के मूल हिंदी लेख जोकि गेहूँ एवम् जौ स्वर्णिमा में प्रकाशित हुए: उपाध्याय, नी*, राकेश कुमार (2020) महिला उद्यमिता के माध्यम से महिला सशक्तिकरण. गेहूँ एवम् जौ स्वर्णिमा (बारहवााँ अंक), पृष्ठ सं. 55-58; भाकृअनुप- भारतीय गेहूँ एवम् जौ अनुसंधान संस्थान, करनाल- १३२००१ द्वारा प्रकाशित\n\n8. Concepts/Processes/Products/Technologies/Patents/Others\n(i)\tConcepts \nCurrently, I am working on the integrated approach of application of green technology for the development of functional foods by utilizing under-utilized/ indigenous fruits and vegetables and/ or bio-waste. In the research projects, I am also keenly working on food chemistry and instrumental food analysis and applications of technologies/ products in dairy and non-dairy products. \nBesides this, I am working on development of functional food for addressing menopausal symptoms in osteopenic mice model. \n(ii)\tProducts/ Technologies ready for commercialization- 5\n1. Production of Milk Protein Concentrate 60 (MPC60), a high protein low lactose powder from buffalo milk (Co-Inventor)\n2. Technology for omega-3 rich mixed fat table spread (Inventor)\n3. Lipid and water soluble yellow natural colouring ingredient from bio-waste (Inventor)\n4. Technology for preparation of encapsulated flaxseed oil for its applications in foods (Inventor)\n5. Production of buffalo milk based Milk Protein Concentrate 60 (MPC60) powder with improved solubility (Co-Inventor)\n(iii) Expertise on\n1.Gas Liquid Chromatography\t5.Thin Layer Chromatography\n2.Fourier Transform Infra-red Spectroscopy\t6. Spectrophotometry\n3.Differential Scanning Calorimetry\t7.Chemical analysis including titration, distillation, etc.\n4.High Pressure Liquid Chromatography\t\n\n\n9. List of completed, on-going and submitted projects\nTitle of Project\tDuration\tRole\tFunding\tStatus\tRemarks\nEffect of storage on Baudouin test, sesamin test and RP-TLC test to detect adulteration of vanaspati and vegetable oils in ghee\t2015-2017\tCo-PI\tICAR-NDRI\n\tCompleted\tTwo research articles on RP-TLC\nPreparation and Characterization of Micro/nano delivery systems for “green” carotenoids\t2016-2019\tPI\t-Do-\t\t3 research articles+ 3 products/ technologies\nTechnology Development for the Production of Milk Protein Concentrate (MPC60) From Buffalo Milk\t2016-2019\tCo-PI\t-Do-\t\t4 research articles+ 2 products/ technologies\nTechnology of Goat Milk based Functional Beverage\t2017-2020\tCo-PI\t-Do-\t\tOne oral presentation\nTechnology for Moringa oleifera enriched cheese spread\t2020-2023\tPI\t-Do-\tOn-going\tCharacterization and incorporation of M. oleifera- pods in cheese spread is complete; shelf life study and animal trial is in progress\nDevelopment of flaxseed-rich probiotic dairy foods to address menopause symptoms\t2020-2023\tCo-PI\tDST\t\tDeveloped method -estimation of phytoestrogen; validation -in progress\nNutritional and therapeutic validation of chhachh and ghee prepared from indigenous cows by traditional method\tThree years (proposed)\tPI\tSEED Division, DST\tSubmitted \n \t\nCharacterization of Moringa oleifera leaves for functional bioactives and its application in table spread as model food system\tThree years (proposed)\tPI\tSYST, DST\t\t\nOther research work: \nDetection of adulteration of goat body fat and pig body fat in ghee using ATR-FTIR coupled with chemometrics; carried out during Professional Attachment Training at ICAR-CIPHET, Ludhiana\n\n\n\n10. Awards & honours \nName of Award\tYear\tAwarding Agency\nBest Paper Award\t2022\tGSAT (Gender Advancement for Transforming Institutions Self-Assessment Team), NDRI\nBest Poster Award\t2021\tNational Conference on Moringa Food Conclave-2021\nYoung Woman Scientist Award\t2020\tAgro Environmental Development Society during International Web-conference \nSecond Best Poster Award\t2020\tIndian Dairy Association\nCommendation certificate for Institute’s Magazine in which I am co-Editor\t2020\tTown Official Language Implementation Committee, Karnal\nLetter of Appreciation to editorial board of Institute’s magazine for receiving ICAR’s Second Prize and Trophy under Ganesh Shankar Vidyarthi Hindi Patrika Puraskar (2018-19)\t2020\tICAR- National Dairy Research Institute, Karnal\nAssociate Fellowship\t2019\tNational Academy of Dairy Science India\nFirst Prize in E-poster \t2018\tIndian Dairy Association\nOne Best oral Presentation\t2018\tHome Science Association of India\nBest Oral Presentation to my Master’s student\t2018\tICMR- National Institute of Nutrition\nBest Poster Award\t2016\tIndian Dairy Association\nSecond Best Paper Award\t2016\tIndian Dairy Association\nICAR-SRF (PGS) with 2nd rank\t2011-12\tICAR\nGATE (Engg Sciences: Food Tech; Thermodynamics)\t2010\tMHRD, GoI\nInstitution level awards\nThird prize in poster presentation \t2021\tICAR- National Dairy Research Institute, Karnal\nInstitute’s Rajbhasha Gaurav Certificate\t2020\t\nFirst prize in Scientific and Technical writing\t2019\t\nConsolation prize in Scientific and Technical writing \t2020, 2019 \t\nFirst prize in Poster Presentation- 2020, 2018, 2017\t\t\nThird prize in poster presentation\t2019\t\nFirst Prize in hindi extempore\t2017\t\nThird, first and second prize in hindi essay writing in consecutive years – 2020, 2019, 2018\t\t\n\n\n11. Teaching Assignments \n(a) Teaching: Actively involved either as course in-charge or associate \nClass\tB.Tech (DT)\tMSc/ MTech\n(FT) (till 2021)\tM.Tech (DT)\tPhD (DT/ DC/ FSQA)\nNo. of courses\t1-2\t2-3\t0-1\t2-3\nDT- Dairy Technology, DC- Dairy Chemistry, FT- Food Technology, FSQA- Food Safety Quality Assurance\n(b) Student’s guided\nDegree\tMajor Advisor \tCo-Advisory\tStatus/ Remarks\nM. Tech (DT)\t8\t2\tCompleted\n\t1\t0\tOn going\nM. Tech/ M Sc (FT/ FSN)\t2\t1\tCompleted\nM. Tech (DC)\t0\t3\tCompleted\nM. Tech (DM)\t0\t1\tCompleted\nPhD (DT)\t2 \t0\tOngoing \n\t0\t2\tCompleted\nPhD (DC)\t0\t1 \tCompleted\n\t\t1\tOn going\ni.\tThree students under my guidance as major advisor and one student as co-advisory member nominated for Best thesis award; \nii.\tOne represented NDRI at zonal-level student research convention ANVESHAN-2018\n\n12. Lectures/ member/convener of committees: \ni.\tLectures: \na.\tEntrepreneurship Development Programme (EDP) (conducted by SINED-TBI/BPD unit, ICAR-NDRI) and Online Training of Master Trainers on Fat and Oilseed processing conducted by SINED-TBI/BPD unit (ICAR-CIPHET); \nb.\tStudent’s Counselling session at SRCASW, University of Delhi, \nc.\tWorkshop conducted at DAV college, Karnal, etc\nd.\tDelivered talks at various villages on the importance of mother’s milk, nutrition in first 1000 days of an infant’s life, nutri-thali, etc\nii.\tTraining Organized: \na.\tTwenty one days Training at Centre for Advanced Faculty Training (DT Division) on ‘R & D strategies and interventions for effective agribusiness and entrepreneurship development in dairy and food sector’; \nb.\tone/two months or shorter duration trainings for students and others under BPD unit and KVK, NDRI, Karnal\nc.\tFive days training on the aspects of dairy processing to the farmers of Karnal district. \niii.\tGeneral Secretary, Staff Club, NDRI, Karnal\niv.\tMember: Student Empowerment Unit, Conferences organized from 2015 till 2018, convocation, credit seminar evaluation committees; Mera Gaon Mera Gaurav program, Farmer’s First Door programme, Swatchh Bharat Abhiyan, coordinator and mentor of different groups for organizing Foundation Program-2017, 2018, Nodal officer of Poshan Maah-2020 etc\nv.\tConvener/ Rapporteur of sessions: Conference, Dr. K. K. Iya Memorial oration; International conference of Proteomics Society of India\nvi.\tOther responsibilities: Management Representative of QMS-IS/ISO 9001:2008 and HACCP- IS 15000:2013 of Experimental Dairy (essential part of institute) until Jan 2019; one of the editors of Institute hindi magazine Dudgh Ganga which also received coveted award from ICAR (until 2019).\nvii.\tResource Generation on account of consultancy provided in field of dairy processing and by conducting sponsored trainings \nMore than ₹ 2 50 000/- (Two lakhs fifty thousand only)\nviii.\tBesides research, teaching and extension activities, I am also involved in promotion of Hindi language and have won several prizes during competitions (like extempore, essay, e-mail writing) organized by Official Language Units.\nix.\tLifetime Member of three scientific bodies: Indian Dairy Association- RE/NZ/LM/10852/HR; Association of Food Scientists & Technologists (INDIA)- AFST/LM/9-2018/KRN/2444; Lifetime member of Home Science Association of India; Membership number: HSAI-2017-HR-127-LF\nx.\tReviewed research papers of Journal of Ayurveda and Integrative Medicine (Elsevier), LWT, International Journal of Food Properties, Indian Journal of Dairy Science, Indian Journal of Natural Products and Resources, United Scientific Group, etc. \n\n\n\n\n\n\n\n\nDated: 12-04-2022\t \nNeelam Upadhyay",institutionString:"National Dairy Research Institute",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Dairy Research Institute",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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1. Introduction
The metal-oxide-semiconductor field effect transistors (MOSFETs) are core switch devices of current large-scale complementary-metal-oxide-semiconductor integrated circuits (CMOS ICs). The performance of the transistor has a critical effect on the performance of IC. As the continuous scaling of the transistor CD for a higher IC performance and integration density, the fabrication process technologies and methods of the transistor are fast changing and becoming relatively complicated. To suppress the short-channel effect as well as the performance degradation of devices, three main new technologies, including strain engineering, high-k/metal gate (HKMG), and FinFET of MOSFETs, are implemented into state-of-art IC manufacture technology. The three technologies are quite important and firstly applied in the CMOS IC manufacturing process by Intel Corporation in the years 2003, 2007, and 2011 at 90-, 45-, and 22-nm node, respectively, which is developed into the industrial standards and widely adopted by other IC manufacturing corporations including TSMC, and Samsung. While the process node of CMOS IC scaling from 22- into 14-nm node, advanced technologies such as film growth, structure design, process optimization, and integration flow of them become more complicated, which often need elaborated process development with diversified knowledge and techniques from different fields.
2. Strain engineering
The effective carrier mobility in the channel of the transistor is crucial to the device’s performance. With the gate length aggressively shrinking down, the electric field magnitude in the channel is strengthened with channel-doping concentration rising, resulting in obvious degradation in effective carrier mobility due to ionized impurity scattering. Mobility both for electron and for hole can be enhanced by changing the silicon atom arrangement of crystal lattice in the channel through the external stress. It is investigated that the tensile and compressive strain for silicon can improve the electron and hole mobility, respectively.
Mobility is closely dependent on the mean free time and the effective mass of the carrier. As we consider the simplified band structure of silicon, there are six equivalent minima at k = (x, 0, 0), (−x, 0, 0), (0, x, 0), (0, −x, 0), (0, 0, x), (0, 0, −x) with x = 5 nm−1 for the conduction band in Ref. [1]. There is one maximum containing two sub-bands at k = 0 for the valence band. These two sub-bands are referred to as the light and heavy hole bands with a light hole effective mass and a heavy hole effective mass. Therefore, the effective mass of these anisotropic minima is characterized by a longitudinal mass along the corresponding equivalent (1, 0, 0) direction and two transverse masses in the plane perpendicular to the longitudinal direction. For the electron in conduction band, the external stress can cause tensile or compressive strain in the silicon lattice. The longitudinal band valley will change. Thus, the corresponding longitudinal mass is changed leading to the mean free time increasing or decreasing for the carriers. For hole in the valence band, the strain effect on the light hole band and heavy hole band is familiar with electron.
For the device, several of strain types for the mobility enhancement are listed in Table 1. Different axial tensile and compressive strain can introduce different mobility enhancement or degradation for electron and hole. Therefore, strain technique is very practical and important for device’s performance promotion. In the point of IC process, this technique is called as strain engineering, which is divided into global strain stress and local strain stress. Global strain stress is less employed in the manufacturing process due to the application regime. Local strain stress can be targeted to enhance carrier’s mobility in the specified region and widely used in the modern IC process flow. Local strain stress can be induced and achieved by IC processes, such as selective epitaxy growth (SEG) of silicon-germanium (SiGe) source/drain, dielectric etch-stop layer (ESL), metal gate, and contact. For PMOS, the most important strain engineering technology is to use selective source/drain epitaxy of SiGe with large lattice constant in order to provide channel with axial compressive stress for hole mobility enhancement as shown in Figure 1.
Direction
NMOS
PMOS
Channel length
Tensile
Compressive
Channel width
Tensile
Tensile
Perpendicular to channel plane
Compressive
Tensile
Table 1.
Strain type for carrier mobility enhancement.
Figure 1.
(a) Homoepitaxy and (b) heteroepitaxy: SiGe with high stress growth on the Si substrate.
The embedded SiGe in source/drain (S/D) region has been widely used to induce uniaxial strain in the channel, especially for the sigma SD epitaxy in Ref. [2]. The strain engineering in 22-nm planar transistor is becoming more complicated. The film growth technique often requires relatively low temperature and the decreasing of pattern dependency. In 22-nm node, the SiGe layers need to be grown at 650°C in a reduced-pressure chemical vapor deposition (RPCVD) reactor and with a series of complicated steps. First, in situ cleaning is performed by annealing in the range of 740–825°C for 3–7 min. Then, dichlorosilane (SiH2Cl2), 10% germane (GeH4) in H2, and 1% diborane (B2H6) in H2 are used as Si, Ge, and B precursors, respectively. Moreover, HCl is utilized as Si etchant to obtain selectivity during the epitaxy. The SiGe growth rate can be denoted by an empirical model (Eq. (1)) in Refs. [3, 4], which considers the contribution of a variety of molecule fluxes coming from different directions toward Si planes during epitaxy in Ref. [5]:
where RV and RLG for Si, Ge, and HCl are the contribution of gas molecules in vertical and lateral directions; RSO and RCO are the mobile reactant molecules on the oxide surface surrounding or within a chip; RIP is the contribution from atoms which diffuse from the edges toward the Si plane. After considering the reaction species and atom activation energy, gas partial pressure, and growth temperature, the final expression for the total growth rate is given by (Eq. (2))
where θCl and θH parameters stand for the occupied dangling bonds by hydrogen and chlorine atoms on Si; N0 is the number of atoms per unit volume for Si; E and P are activation energy and partial pressure for different reactant molecules, respectively. The variable c is the exposed Si coverage of Si chip where B is a unit-less constant which is dependent on the architecture of the mask. The equation constants, β, χ, and γ, are tooling factors which depend on the temperature distribution and gas kinetic over the susceptor in the CVD reactor. Therefore, a series of process parameters are affecting the growth of SEG SiGe in 22-nm PMOS transistor, resulting in different growth rates, Ge content, film quality as well as the compressive stress to the channel. The stress distribution has also a strong relationship to the growth area, pattern intensity, and locations around the wafer.
For integrating SEG SiGe into 22-nm PMOSFET, a sacrificial epitaxy-block Si3N4 layer is deposited on whole wafer after the formation of dummy polysilicon gate and spacers. In the next step, the block layer is selectively opened and low-temperature epitaxy SiGe with high stress is performed at the source/drain region of PMOS.
The amount of strain induced by SiGe is dependent on the initial recess shape, interfacial quality of SiGe/Si, and defect density in the epilayers. Sigma-shaped recesses with (100) and {111} planes are very suitable shape for embedded SiGe in source/drain regions with the highest stress. Moreover, in such transistors, shorter distance between sigma-shaped recesses and channel region can generate a higher stress to the channel region. By applying dry etch together with wet etch in Si substrate, the sigma-shaped recesses turn more large and induce a stronger stress of embedded SiGe with a closer distance to the channel in Ref. [5].
For NMOS, PMD (pre-metal dielectric) layer is deposited as ESL, which can offer axial tensile stress to the channel for electron mobility enhancement [6]. In the modern IC manufacturing integrated process, more and more strain process is employed for the devices, which is of great significance to suppress the device’s performance degradation. However, the film thickness of ESL is limited due to the scaling of gate pitch between transistors. New techniques, such as metal gate and contact electrode stress of NMOS, are necessary. The TiN metal gate and the W plug often bring effective tensile stress into the channel of NMOSFET, resulting in the enhancement of motilities for electrons.
3. High-k/metal gate
High-k/metal gate (HKMG) is a very important technique for modern CMOS IC manufacturing process. While the transistor CD scaling down, conventional oxide dielectric/polysilicon gate was formally replaced by high-k dielectric/metal gate, in order to suppress the unbearable leakage in the ultra-thin oxide dielectric film in Ref. [7]. HKMG technique has found a new effective path for equivalent oxide thickness (EOT) scaling tendency, which is of deep significance to continuous scaling of MOS transistors. However, HKMG brings about a series of challenges, including new high-k dielectric and metal gate materials, threshold voltage modulation, and process integration scheme. To some extent, the scaling of MOS transistor relies on the scaling of EOT of gate dielectric. When the conventional oxide film thickness shrinks to about 11–12 A, the transistor shrinking cannot be continued due to the extremely large leakage current from the gate to the substrate by the electron direct tunneling through the ultra-thin oxide film. EOT is defined as (Eq. (3)).
EOT=THK∙εOXεHKE3
where THK is the physical thickness of high-k dielectric, εOX is the SiO2 dielectric constant, and εHK is the high-K dielectric constant. When it comes to high-k dielectric materials, the physical thickness of the gate dielectric is increased because of the high value of dielectric constant parameter. Hence, the gate leakage current induced by direct tunneling is reduced dramatically to continue the scaling of EOT.
Many high-k materials have been investigated for CMOS devices including metal oxide (HfO2, ZrO2, Al2O3, etc.) as shown in Table 2. Among these metal-oxide materials, HfO2 has the advantages of the moderate relative permittivity value, the basically symmetrical energy band offset to silicon conduction band and valence band, and the uniformly amorphous structure. Therefore, HfO2 material is applied in the IC manufacturing production.
Material
Dielectric constant
Material
Dielectric constant
Al2O3
8–11.5
NdAlO3
22.5
(Ba, Sr)TiO3
200–300
PrAlO3
25
BeAl2O4
8.3–9.43
Si3N4
7
CeO2
16.6–26
SmAlO3
19
HfO2
26–30
SrTiO3
150–250
Hf silicate
11
Ta2O5
25–45
La2O3
20.8
TiO2
86–95
LaAlO3
23.8–27
Y2O3
8–11.6
LaScO3
30
ZrO2
22.2–28
Table 2.
High-k dielectric constant.
In the early 1990, it is reported that the integration of polysilicon gate with HfO2 dielectric results in serious Fermi Level Pinning (FLP) phenomenon, where the Fermi level of polysilicon gate is fixed at the poly/HfO2 interfacial energy level. Although some theories including oxygen vacancy model, and dipole formation, are put forward to explain the pinning effect, the process cannot successfully release the effect of FLP, which causes huge difficulties on the device’s threshold voltage modulation. Therefore, different metal gates with the high-k material are corresponded to different threshold voltage modulation regimes for PMOS and NMOS.
3.1. HKMG film stack
The introduction of high-k/metal gate provides great potential of transistor’s scaling down under 45-nm node. Metal gate can reduce oxide thickness by eliminating polysilicon gate depletion effect. Metal gate has a low gate resistance and can suppress boron penetration to the substrate in Refs. [8, 9, 10].
In 22-nm node, the main challenge and research hotpot for HKMG stack lie in the effective work function (EWF) modulation of metal gate. The EWF can be defined as the value between Fermi level of metal gate and vacuum level in the metal-oxide-semiconductor system. As shown in Figure 2, EWF is defined as (Eq. (4))
EWF=E0−EFM,E4
where E0 is the vacuum energy level, and EFM is the Fermi level of metal gate. When EFM is close to the conduction band edge EC or valence band edge EV of Si substrate, EWF will get the minima or the maximum value for the MOS device. Generally, the mid-gap EWF is around 4.6 eV, and the band edge EWF is less than 4.4 for conduct band in NMOS or is high than 4.8 eV for valence band in PMOS.
Figure 2.
Illustration of band edge EWF of metal gate for PMOS.
Fermi level of metal gate can be shifted both upwards and downwards. The Fermi level (EF) of metal gate is set to be in the position of mid-gap in the substrate. When Fermi level shifts to the conduction band of Si substrate, the effective work function of metal gate decreases. On the other hand, when Fermi level shifts to the valence band of Si substrate, the effective work function of metal gate increases. The EWF movement behaviors can directly drive the threshold voltage (Vt) modulation for the MOS devices.
The most effective method to manipulate EWF is the selection of metal gate. For PMOS, a large EWF is preferred to achieve high Vt for low-power (LP) IC performance. Hence, Fermi level of PMOS metal gate is ideally near to the valence band maximum of silicon substrate, where the position in the valence band minima of silicon is the best choice for Fermi level of metal gate. For NMOS, a small EWF is preferred to achieve high Vt for LP IC performance, where the Fermi level of NMOS metal gate is ideally near to or at the conduction band minima of silicon substrate. Therefore, the demand of the large EWF for PMOS and small EWF for NMOS is selecting TiN with a high work function and TiAl with a low work function metals.
For the multi-Vt modulation of PMOS and NMOS, the most general method is to tune the gate-stack thickness control in Refs. [11, 12], in order to realize the regular, low, and high Vt levels. As shown in Figure 3, the metal gate stack can be divided into three layers: the first is the bottom-capping layer for the high-k dielectric, the second is exactly the work function layer, and the last is the top-capping layer for the contacted metal. Moreover, the etch-stop layer should be considered for the dual work function metal integration of PMOS and NMOS. Although the gate stack contains three parts, the effective work function of the entire gate electrode is dominated by the work function layer metal, where EWF sensitivity is strictly limited by the bottom-capping layer thickness, and the top-capping layer acts as the barrier layer for the contacted metal (tungsten). Therefore, the thickness control of metal gate-stack design is exactly of precision and significance.
Figure 3.
HKMG gate stack.
3.2. Gate-first and gate-last integration scheme
The novel gate-stack structure of HKMG has been implemented for MOSFETs to promise conventional scaling of the high-performance CMOS process down to the 45/32-nm node. Two completely different integration schemes were proposed [13]. With the HKMG in the IC process flow, a big question arises that the module of HKMG structure formation is ahead of or after the module of source/drain process. Gate-first process integration scheme is familiar with poly-Si/SiO2 process flow. HKMG module is firstly deposited after the active-region formation module, and then source/drain module formation module is following until the end. However, with the source/drain formation later than HKMG formation module, the high annealing temperature for the S/D doping profile has a serious impact on HKMG characteristics and its reliability.
To overcome shortcoming caused by gate-first integration scheme, gate-last integration scheme is put forward. In the gate-last process, conventional poly-Si/SiO2 is still formed on the wafer substrate firstly. After poly-Si/SiO2 formation module, it is followed by the S/D impurity doping and its activation with annealing process at high temperature ambient. Then, PMD layer is deposited on the poly-Si dummy gate, where PMD is also called an inter-layer-dielectric zero layer (ILD0). With poly-Si-open planarization (POP) chemical mechanical polishing (CMP), poly-Si gate is exposed for the following removal of poly-Si/SiO2 process. Finally, HKMG is deposited in the position where poly-Si dummy gate previously existed, which is called gate-last process due to HKMG module later than the middle end of line (MEOL) process. The implement of gate-last integration scheme avoids the damage to devices by the high annealing temperature of S/D process. Therefore, gate-last integration scheme has obvious performance advantages for HKMG devices and becomes popular technique applied beyond 28 nodes.
In gate-last technique, it is divided into two integration schemes: high-k first/metal-gate last and high-k last/metal-gate last. In the first approach, the high-k layer is deposited together with the formation of dummy gate and before the annealing of source/drain, where only metal gate stack is formed with gate-last scheme. In the second approach, both high-k and metal gate are formed after the annealing of source/drain, which is also called all gate-last integration scheme. It has better film quality and process adjustment window than the former and is widely adopted for CMOS IC fabrication process in 22 nm and beyond node. In this integration scheme, multilayer HKMG stacks are IL/HfO2/TiN/TaN/TiN/W and IL/HfO2/TiN/TiAlC/TiN/W for PMOS and NMOS, respectively. IL layer is an interfacial layer between HK and substrate and is normally SiO2 forming by chemical oxidation method. All HKMG depositions are finished by atomic layer deposition (ALD) approach with a high conformality and a precise thickness control ability.
4. FinFET technology
While process node scaling from 22 to 14 nm, the basic architecture of the transistor is changing from 2D planar device to 3D volume inversion device for a better control of SCE in channel with less leakage. The device design as well as the process techniques turns more complicated and needs a more elaborated technologies.
4.1. FinFET transistors
With feature size of CMOS IC shrinking to 20-nm node and beyond, the structure of the conventional planar MOSFET consisting of single-gate electrode to control channel potential distribution and the flow of current in the channel region is faced with the undesirable parasitic effects called short-channel effect (SCE) and drain-induced barrier lowering (DIBL) effect. Via voltage-doping transformation (VDT) model [14], the device’s structure and material parameters can be translated into electrical parameters with electrostatic integrity (EI) (Eq. (5)). SCE and DIBL can be derived as (Eqs. (6) and (7))
EI=1+xj2Lch2toxLchtdepLchE5
SCE=0.64εSiεoxEIVbi,E6
DIBL=0.8εSiεoxEIVdsE7
where Lch is the effective channel length, Vbi is the source or drain built-in potential, tox is the gate oxide thickness, xj is the source/drain junction depth, and tdep is the penetration depth of the gate electric field in the channel region. The parameter EI is denoted as electrostatic integrity factor.
The threshold voltage of MOSFET can be denoted as (Eq. (8))
VT=VT_long−SCE−DIBLE8
According to the above expression, SCE can be minimized by reducing the junction depth, gate oxide thickness, and depletion depth via increasing the doping concentration in the channel region. However, the limits on the reducing junction depth and gate oxide thickness have become very toughly serious in the practical device. Hence, SCE and DIBL values of the planar MOSFET are not controlled well in the ultra-short-channel length.
The most efficient and direct way to suppress SCE is to strengthen the gate electric field control capability by double-gate (DG) or multi-gate (MG) structure. DG or MG structures on thin Si channel improve the electrostatic integrity of MOSFET (Eq. (9)) with the transistor working in a volume inversion mode due to a reduced device structure parameter, which decreases the SCE and DIBL effects on the device electric parameters, such as threshold voltage, sub-threshold slope (SS), and DIBL voltage. In the equation, since the thickness of Si is much smaller than that of depletion region in planar transistor, EI is obviously improved. The whole new structures of MOSFET extend the shrinking boundary of the ultra-short gate length
EI=121+tSi2/4Lch2toxLchtSi/2LchE9
FinFET is a typical double-gate or multi-gate device with a three-dimensional channel structure, as shown in Figure 4. The FinFET is made of a tall and narrow silicon island. The 3D channel is standing above the silicon substrate, where the ultra-thin silicon body is familiar with the fin of the fish. The fin channel under the gate can be fully depleted by electrostatic potential, providing a strong ability of controlling the carriers’ behaviors in the channel. FinFET can really expand the limit of the shrinking size and is widely adopted for the 16/14-nm technology node and beyond. FinFET can effectively suppress the leakage of the sub-surface channel, which can obviously reduce the off-state current for the device’s current-voltage transfer characteristic. In the meantime, the fully depleted channel can obtain benefit of carriers’ mobility with less scattering. For the 3D fin structure, the transistor’s width can be doubled compared to the planar one in the projected plane, which can improve the driving current at on-state in the saturation regime. With the same drive current, the supply voltage of FinFET can be significantly reduced regardless of the planar transistor’s power limit, where the suppression of power consumption in modern integrated circuits emphasizes energy efficiency ratio.
Figure 4.
FinFET from fin to whole device.
4.2. FinFET integration process
Since 22-nm technology node, FinFET has been utilized for several process nodes [15, 16, 17]. It is firstly introduced by Intel in 22-nm node and widely adopted by different companies in 16- or 14-nm process node. The process integration scheme of FinFET is compatible with that of the planar transistor. In a general way, the critical fabrication steps of FinFET transistor include silicon fin formation on the substrate by the spacer-transfer lithography (STL), shallow trench isolation (STI) formation and recess, 3D dummy gate formation and planarization, 3D spacer formation, source/drain with 3D selective SEG, 3D HKMG formation, and back-end-of-line (BEOL) metallization and contact techniques. It added a little extra process steps than those of planar transistor fabrication. It is very meaningful to understand the integration process of FinFET. In future, the next-generation devices, such as gate-all-around nanowire transistor or nanosheet FET, are still dependent on current FinFET integration flow [18, 19].
4.2.1. Spacer-transfer lithography for bulk fin formation
Oxide by plasma-enhanced CVD (PECVD), poly-Si by low-pressure CVD (LPCVD), and SiNx by PECVD are sequentially deposited in the substrate for the formation of etch-hard-mask (EHM). After etching EHM with pattern, another SiNx is deposited as the spacer of the core layer of oxide/poly-Si/SiNx structure. After spacer and Si dry etch, the 3D Si fin is formed and the Si fin width depends on the SiN spacer thickness, as shown in Figure 5. The fin width may be beyond the lithography resolution limit and often smaller than 10 nm.
Figure 5.
STL for bulk fin formation (a) Hard mask deposition; (b) Hard mark etch; (c) SiN spacer deposition and etch; (d) Fin structure etch.
4.2.2. STI formation and recess
For adjacent fins isolation, high-aspect-ratio-process (HARP) oxide deposition is widely used with a good step coverage on 3D fins. The oxide for HARP STI is deposited by sub-atmospheric CVD (SACVD) with the reaction by tetraethoxysilane (TEOS) precursor and O3. After the isolation oxide annealing, chemical mechanical polishing is utilized for the planarization of deposited dielectric on 3D fins. In following steps, the oxide is precisely etched back and making the fin final formation with shallow trench isolation structures as shown in Figure 6.
Figure 6.
STI formation and recess on 3D fins (a) Fin and STI structure after recessng; (b) SEM images for Fin and STI after recessing.
4.2.3. 3D dummy gate formation
On 3D fins with STI, thin oxide is firstly formed on the surface. Then, amorphous-Si (α-Si) is deposited as dummy gate on the fin. However, the dummy gate etch is the most challenging, for which the top dummy gate needs to be protected during the etching and sidewall and the foot of the dummy gate needs strong etching capability to prevent the residue of Si and no process damage on the exposed fin tip (Figure 7).
Figure 7.
3D dummy gate formation (a) PolySi deposition, planarization and dummy gate etch; (b) SEM image after dummy gate formation.
4.2.4. Source/drain 3D SEG
On 3D fin, it often needs SEG on source/drain regions for less contact resistance. Source/drain selective epitaxy growth normally employs SiH2Cl2, GeH4, and HCl gases. Especially, for PMOS source/drain, B2H6 is mixed into the carrier gas of the reaction. The selectivity of SiGe epitaxy is mainly due to the function of HCl gas, where the etch rate of polycrystalline SiGe is higher than that of single crystalline of SiGe by HCl. In the whole process, the dilution protective gas contains N2 or H2 all the time. Due to the slowest growth rate on Si (111) lattice plane, as shown in Figure 8, the final formed SiGe shape on 3D fin is more like a diamond. The film stress not only depends on the process conditions but also is strongly affected by the surface quality of fins.
Figure 8.
SEG SiGe on 3D fin.
5. Conclusions
Advanced transistor technologies were extensively implemented into the CMOS IC manufacture with the process node scaling from 22 to 14 nm. They require new materials and novel structures as well as complicated process techniques and different device integration flow. This chapter presented a summary on the three important techniques, strain engineering, high-k/metal gate, and FinFET. Both the process theory related to the suppress on SCE for device’s shrinking and the detailed illustration on material choice, film growth method, architecture design, critical process definition, and integration are presented in a comprehensive and systematic manner. The process condition optimizations for suppressing stress release are key technologies of strain engineering. The high-k/metal gate needs multilayer structure for modulating Vt in a different manner for PMOS and NMOS, respectively. The integration scheme is also changed from gate-first to all-last integration. FinFET requires a sophisticated device integration structure and a flow design with less extra process cost. It also has some new fabrication techniques, such as ultra-thin fin formation with STL and improved process methods, including HKMG and SiGe SEG in 3D approach.
Acknowledgments
The reported work was supported by “16/14nm Basic Technology Research” of national 02 IC R&D projects in China (No. 2013ZX02303). The authors would like to thank all the colleagues in Integrated Circuit Advanced Process Center, IMECAS, for their kind and great support.
Conflict of interest
The authors declare that they have no competing interests.
\n',keywords:"CMOS, high-k/metal gate, strain, FinFET, process",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/62046.pdf",chapterXML:"https://mts.intechopen.com/source/xml/62046.xml",downloadPdfUrl:"/chapter/pdf-download/62046",previewPdfUrl:"/chapter/pdf-preview/62046",totalDownloads:1714,totalViews:476,totalCrossrefCites:2,totalDimensionsCites:2,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:69,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"February 20th 2018",dateReviewed:"May 14th 2018",datePrePublished:"November 5th 2018",datePublished:"August 1st 2018",dateFinished:"June 11th 2018",readingETA:"0",abstract:"Transistor performance meets great technical challenges as the critical dimension (CD) shrinking beyond 32/28-nm nodes. A series of innovated process technologies such as high-k/metal gate, strain engineering, and 3D FinFET to overcome these challenges are reviewed in this chapter. The principle, developing route, and main prosperities of these technologies are systematically described with theoretical analysis and experimental results. Especially, the material choice, film stack design, and process flow integration approach with high-k/metal gate for sub-22-nm node is introduced; the film growth technique, process optimization, and flow integration method with advanced strain engineering are investigated; the architecture design, critical process definition, and integration scheme matching with traditional planar 2D transistor for 14-nm 3D FinFET are summarized.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/62046",risUrl:"/chapter/ris/62046",book:{id:"6511",slug:"complementary-metal-oxide-semiconductor"},signatures:"Huaxiang Yin and Jiaxin Yao",authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Strain engineering",level:"1"},{id:"sec_3",title:"3. High-k/metal gate",level:"1"},{id:"sec_3_2",title:"3.1. HKMG film stack",level:"2"},{id:"sec_4_2",title:"3.2. Gate-first and gate-last integration scheme",level:"2"},{id:"sec_6",title:"4. FinFET technology",level:"1"},{id:"sec_6_2",title:"4.1. FinFET transistors",level:"2"},{id:"sec_7_2",title:"4.2. FinFET integration process",level:"2"},{id:"sec_7_3",title:"4.2.1. Spacer-transfer lithography for bulk fin formation",level:"3"},{id:"sec_8_3",title:"4.2.2. STI formation and recess",level:"3"},{id:"sec_9_3",title:"4.2.3. 3D dummy gate formation",level:"3"},{id:"sec_10_3",title:"4.2.4. Source/drain 3D SEG",level:"3"},{id:"sec_13",title:"5. Conclusions",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"},{id:"sec_17",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Vasileska D, Goodnick SM. Computational electronics. Synthesis Lectures on Computational Electromagnetics. 1st ed. San Rafael, CA, USA: Morgan & Claypool Publishers; 2006. 20 p. 1-216. 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Key Laboratory of Microelectronics Devices and Integrated Technology, Institute of Microelectronics of Chinese Academy of Science, Beijing, China
Key Laboratory of Microelectronics Devices and Integrated Technology, Institute of Microelectronics of Chinese Academy of Science, Beijing, China
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1. Introduction
Fractional derivatives (FD) initiative concept is quite old and its history spans three centuries. The variety of papers dedicated to FD is multiplied swiftly in the mid-twentieth century and later decades. One of the motives for the full-size interest within the discipline of FD is that it’s far feasible to describe the variety of physical [1], synthetic [2], and organic [3] occurrence with fractional differential equations (FDEs). As a new branch of applied mathematics, the field of FD can be seen in many applications. Nevertheless, more and more compelling implementations have been found in various engineering and science fields over the past few decades (see [4]). It is noted that the existing theory of FDEs is committed to a larger part of the research works (see [5, 6, 7, 8]). While modeling functional structures, ambient noise and time delays need to be taken into account, which might be very beneficial in building extra sensible fashions of sciences, and so on [9]. It is referred to as the pattern direction houses of the stochastic fractional partial differential gadget powered by way of area time white noise [10].
The problems in a stochastic environment replicate the modeling of single-sever m-mode random queues in computer networks [11], the spatial distribution of mobile users in the telecommunications network coverage area [12], and other anomalies that occurred naturally in many disciplines [13]. Authors in [14] investigated the existence, uniqueness, and large deviation principle solutions to stochastic evolution equations of jump type. Among the many meaningful properties of stochastic stability results describe the maximum vital feature of fractional order stochastic systems and have been investigated in Refs. [15, 16, 17, 18]. The notion of finite-time stability for fractional stochastic delay systems occurs a matter of course in stochastic control systems. Without any doubt that this type of fractional stochastic stability is most important in both theory and applications.
However, only few introductions and discussions exist on the definition of finite-time stability in stochastic finite space using fixed point theorem approach. Burton [19] started to analyze the stability characters of dynamical systems broadly using fixed point theorems. Subsequently, few authors applied fixed point approach to establish sufficient conditions for stability of the differential systems (see [20, 21, 22, 23, 24]). Based on the above discussions, this chapter provides finite-time stability of the Caputo sense FDEs via fixed point theorems.
The primary contribution of this chapter is defined as follows:
A fractional higher-order stochastic delay system (FSDS) is considered in finite-dimensional stochastic settings.
Weaker hypothesis on nonlinear terms and appropriate fixed-point analysis are utilized to obtain the existence and uniqueness of solution.
A new set of generalized sufficient conditions for finite-time stability of a certain FSDS is established by using Generalized Gronwall-Bellman inequality.
Novelties and challenges of this chapter are described through the subsequent statements:
Finite-time stability analysis for FSDS is new in literature of finite-dimensional fractional stochastic settings.
It is a challenge to tackle the proposed system with a norm estimation on nonlinear stochastic terms as described in this chapter.
It is more complex to verify the weaker assumptions of the system and the derived result is new, has not been analyzed with the existing literature.
Obtained result is proved in stochastic nature with square norm settings.
Organization of this chapter is as follows: system description and preliminaries are provided in Section 2. Existence and uniqueness of solution are provided in Section 3. Finite-time stability result is proved in Section 4 and Section 5 consists of a numerical example.
Notations:CD−κ+q represent respectively the Caputo derivative with q∈01;Rn and Rn×n represent the n−dimensional Euclidean space and n×n real matrix; E⋅ denotes the mathematical expectation with some probability measure; Ω=LF020bRn∥⋅∥; for any y∈Rn, we define the norm
where yη∈Rn is a state vector. Here, M∈Rn×n is taken as a nonsingular matrix. F is mapping from 0b×Rn to Rn and Δ is a mapping from 0b×Rn to Rn×d are nonlinear continuous function and ψ∈C1−κ0Rn is an initial value function. w denotes d−dimensional Wiener process.
Definition 2.1. ([5]) The Caputo derivative forf:−κ∞→R,is
Definition 2.5.System(1)satisfyingyη≡ψηandy′η≡ψ′ηfor−κ≤η≤0is finite-time stable in mean square with respect to00bδεκ,if and only ifδ1<δδ>0impliesE∥yη∥2<εε>0,∀η∈0bwhereδ1=max∥ψ∥2∥ψ′∥2denotes the initial time of observation of the system.
Lemma 2.1.[26](Generalized Gronwall-Bellman inequality) Letvη,bηbe nonnegative and locally integrable on0≤η<band lethηbe a nonnegative, nondecreasing continuous function defined on0≤η<b,hη≤M,and letMbe a real constant,q>0with
vη≤bη+hη∫0ηη−ζq−1vζdζ
and then
vη≤bη+∫0η∑k=1∞hηΓqkΓkqη−ζkq−1vζdζ.
Moreover, ifbηis a nondecreasing function on0b.Then
vη≤bηEq,1hηΓqηq,η∈0b,
where Eq,1⋅ is the one parameter Mittag-Leffler function.
Assumption 1: Let x,y∈Rn, then we take
supη∈−κbe−2Nηxη−yη2=E∥xη−yη∥2.
Lemma 2.2.For a nonsingular matrixM,the solution of the inhomogeneous system is
Hence, from statement of the Theorem 3.1, the nonlinear operator (P) is a contraction. Hence the nonlinear operator (P) has a unique solution y⋅∈Rn, which is nothing but solution of Eq. (1). Hence the proof. □
4. Finite-time stability
Theorem 4.1.If Assumption 1 hold and provided that
5K1+M−12K3+K2−2K3K2+κ2K2Eq,15b2−q2−qK2Γqηq≤εδ.
Then the system(1)is finite-time stable in mean square.
Proof. By multiplying e−2Nη on both sides of the solution of system (1), we derive
Hence the system (1) is finite-time stable in mean square. Hence the proof. □
Remark 4.1.By using fixed-point rule, existence and uniqueness of solution, and controllability results have been investigated in [27]. Some well-known results on relative controllability of semilinear delay differential system with linear parts defined by permutable matrices are studied in [28]. In this chapter, we proved some new results of finite-time stability criteria in finite-dimensional space by employing Generalized Gronwall-Bellman inequality and suitable assumption on nonlinear terms.
From Eq.(5) and using basic calculation, one can get E2q∥M∥2b+κ2q2=0.9712,e−Nb−1Nb2=0.2683 and 4be−2Nb−12Nb=−1.9004. Using the above-obtained values, one can easily verify that
2E2q∥M∥2b+κ2q2e−Nb−1Nb2+4be−2Nb−12Nb<1.
Hence we verified Theorem 3.1. Further, it is easy to verify that for any xη,yη∈R2.
e−2NηF(ηxη)−F(ηyη)2≤−3−ηE∥xη−yη∥2
e−2NηΔ(ηxη)−Δ(ηyη)2≤−0.5ηE∥xη−yη∥2
Hence, F and Δ satisfies Assumption 1. In Figures 1 and 2, we showed the stable response of the system (4) with fractional order q=0.5 and q=0.7, respectively. From the above verification, one can conclude that the system (4) is finite-time stable in mean square.
Figure 1.
The system 4 is stable at q=0.5.
Figure 2.
The system 4 is stable at q=0.7.
6. Conclusion
In this chapter, we have derived some meaningful and general results for finite-time stability of nonlinear fractional stochastic delay systems. Existence, uniqueness of solution and stability analysis of FSDS have been proved in finite-dimensional stochastic fractional higher-order differential system. Finally, a numerical simulation test is carried out to validate the obtained theoretical results. Derived result generalizes many existing results with integer and fractional-order systems.
AMS subject classifications (2010)
34A08; 43A15; 37C25; 37A50
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Fractional Calculus for Scientists and Engineers. New York: Springer Science & Business; 2011'},{id:"B5",body:'Kilbas AA, Srivastava HM, Trujillo JJ. Theory and Applications of Fractional Differential Equations. Amsterdam: North-Holland Mathematics Studies, Elsevier; 2006'},{id:"B6",body:'Nieto JJ. Solvability of an implicit fractional integral equation via a measure of noncompactness argument. Acta Mathematics Scientia. 2017;37:195-204'},{id:"B7",body:'Singh J, Kumar D, Nieto JJ. Analysis of an el nino-southern oscillation model with a new fractional derivative. Chaos, Solitons and Fractals. 2017;99:109-115'},{id:"B8",body:'Tian Y, Nieto JJ. The applications of critical-point theory discontinuous fractional-order differential equations. Proceedings of the Edinburgh Mathematical Society. 2017;60:1021-1051'},{id:"B9",body:'Mao X. Stochastic Differential Equations and Applications. Chichester: Horwood Publishing, Cambridge; 1997'},{id:"B10",body:'Wu D. On the solution process for a stochastic fractional partial differential equation driven by space-time white noise. Statistics and Probability Letters. 2011;81:1161-1172'},{id:"B11",body:'Seo D, Lee H. Stationary waiting times in m-node tandem queues with production blocking. IEEE Transactions on Automatic Control. 2011;56:958-961'},{id:"B12",body:'Taheri M, Navaie K, Bastani M. On the outage probability of SIR-based power-controlled DS-CDMA networks with spatial Poisson traffic. IEEE Transactions on Vehicular Technology. 2010;59:499-506'},{id:"B13",body:'Applebaum D. Levy Processes and Stochastic Calculus. Cambridge: Cambridge University Press; 2009'},{id:"B14",body:'Rockner M, Zhang T. Stochastic evolution equations of jump type: Existence, uniqueness and large deviation principle. Potential Analysis. 2007;26:255-279'},{id:"B15",body:'Ahmed E, El-Sayed AMA, El-Saka HAA. Equilibrium points, stability and numerical solutions of fractional-order predatorprey and rabies models. Journal of Mathematics Analysis and Applications. 2007;325:542-553'},{id:"B16",body:'Gao X, Yu J. Chaos in the fractional order periodically forced complex duffing oscillators. Chaos, Solitons and Fractals. 2005;24:1097-1104'},{id:"B17",body:'Odibat ZM. Analytic study on linear systems of fractional differential equations. Computers and Mathematics with Applications. 2010;59:1171-1183'},{id:"B18",body:'Wang J, Zhou Y, Fečkan M. Nonlinear impulsive problems for fractional differential equations and Ulam stability. Computers and Mathematics with Applications. 2012;64:3389-3405'},{id:"B19",body:'Burton TA, Zhang B. Fractional equations and generalizations of Schaefers and Krasnoselskii’s fixed point theorems. Nonllinear Analysis: Theory, Methods and Applications. 2012;75:6485-6495'},{id:"B20",body:'Balasubramaniam P, Sathiyaraj T, Priya K. Exponential stability of nonlinear fractional stochastic system with Poisson jumps. Stochastics. 2021;93:945-957'},{id:"B21",body:'Fečkan M, Sathiyaraj T, Wang JR. Synchronization of Butterfly fractional order chaotic system. Mathematics. 2020;8:446'},{id:"B22",body:'Ren Y, Jia X, Sakthivel R. The p-th moment stability of solutions to impulsive stochastic differential equations driven by G-Brownian motion. Applicable Analysis. 2017;96:988-1003'},{id:"B23",body:'Shen G, Sakthivel R, Ren Y, Mengyu L. Controllability and stability of fractional stochastic functional systems driven by Rosenblatt process. Collectanea Mathematica. 2020;71:63-82'},{id:"B24",body:'Sathiyaraj T, Wang JR, Balasubramaniam P. Ulam’s stability of Hilfer fractional stochastic differential systems. The European Physical Journal Plus. 2019;134:605'},{id:"B25",body:'Liang C, Wang J, O’Regan D. Representation of a solution for a fractional linear system with pure delay. Applied Mathematics Letters. 2018;77:72-78'},{id:"B26",body:'Ye H, Gao J, Ding Y. A generalized Gronwall inequality and its application to a fractional differential equation. Journal of Mathematical Analysis and Applications. 2007;328:1075-1081'},{id:"B27",body:'Sathiyaraj T, Balasubramaniam P. Fractional order stochastic dynamical systems with distributed delayed control and Poisson jumps. The European Physical Journal Special Topics. 2016;225:83-96'},{id:"B28",body:'Wang J, Luo Z, Fečkan M. Relative controllability of semilinear delay differential systems with linear parts defined by permutable matrices. European Journal of Control. 2017;30:39-46'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Sathiyaraj Thambiayya",address:null,affiliation:'
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I have seven published books and many papers.",institutionString:null,institution:null},{id:"182978",title:"Dr.",name:"Baotong",surname:"Li",slug:"baotong-li",fullName:"Baotong Li",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"184279",title:"Prof.",name:"Hong",surname:"Zhao",slug:"hong-zhao",fullName:"Hong Zhao",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"185675",title:"Prof.",name:"Peter",surname:"Wall",slug:"peter-wall",fullName:"Peter Wall",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"188490",title:"Prof.",name:"Hans-Herwig",surname:"Priebsch",slug:"hans-herwig-priebsch",fullName:"Hans-Herwig Priebsch",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"190735",title:"M.Sc.",name:"Majid",surname:"Abdulmajeed",slug:"majid-abdulmajeed",fullName:"Majid Abdulmajeed",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"our-story",title:"Our story",intro:"
The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
\\n\\n
2005
\\n\\n
\\n\\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\\n
\\n\\n
2006
\\n\\n
\\n\\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\\n
\\n\\n
2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\\n
\\n\\n
2013
\\n\\n
\\n\\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\\n
\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
\\n\\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\\n
\\n\\n
2015
\\n\\n
\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\\n\\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\\n\\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
\\n\\n
\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\\n
\\n\\n
2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
\n\n
\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
\n\n
2016
\n\n
\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
\n\n
2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\n\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain. She is a Full Professor at the Department of Medicine and Animal Surgery at the same University. She developed her research activity in the field of Endocrinology, Hematology, Biochemistry and Immunology of horses. She is a scientific reviewer of several international journals : American Journal of Obstetrics and Gynecology, Comparative Clinical Pathology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology. Since 2014, she has been the Head of the Clinical Analysis Laboratory of the Hospital Clínico Veterinario from the Faculty of Veterinary, CEU-Cardenal Herrera University.",institutionString:"CEU-Cardenal Herrera University",institution:{name:"CEU Cardinal Herrera University",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"345713",title:"Dr.",name:"Csaba",middleName:null,surname:"Szabó",slug:"csaba-szabo",fullName:"Csaba Szabó",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"345719",title:"Mrs.",name:"Márta",middleName:null,surname:"Horváth",slug:"marta-horvath",fullName:"Márta Horváth",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"420151",title:"Prof.",name:"Novirman",middleName:null,surname:"Jamarun",slug:"novirman-jamarun",fullName:"Novirman Jamarun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}},{id:"420149",title:"Dr.",name:"Rusmana",middleName:"Wijaya Setia",surname:"Wijaya Setia Ningrat",slug:"rusmana-wijaya-setia-ningrat",fullName:"Rusmana Wijaya Setia Ningrat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}},{id:"339759",title:"Mr.",name:"Abu",middleName:null,surname:"Macavoray",slug:"abu-macavoray",fullName:"Abu Macavoray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Njala University",country:{name:"Sierra Leone"}}},{id:"339758",title:"Prof.",name:"Benjamin",middleName:null,surname:"Emikpe",slug:"benjamin-emikpe",fullName:"Benjamin Emikpe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ibadan",country:{name:"Nigeria"}}},{id:"339760",title:"Mr.",name:"Moinina Nelphson",middleName:null,surname:"Kallon",slug:"moinina-nelphson-kallon",fullName:"Moinina Nelphson Kallon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Njala University",country:{name:"Sierra Leone"}}}]}},subseries:{item:{id:"17",type:"subseries",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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