Clinical symptoms associated with MFS.
\r\n\tLiterature showed the presence of ACE2 receptors on the membrane of erythrocyte or red blood cell (RBC), indicating that erythrocyte (RBC) can be considered as a peripheral biomarker for SARS-C0V2 infection.
\r\n\r\n\tIncreased levels of glycolysis and fragmentation of RBC membrane proteins were observed in the SARS-C0V2 infected patients, demonstrating that not only RBC’s metabolism and proteome but its membrane lipidome could be influenced by SARS-C0V2 infection changing the homeostasis of the infected erythrocyte. This altered RBC may result in the clot and thrombus formation; the major signs of critically ill Covid-19 patients.
\r\n\r\n\tThis book is going to be a succinct source of knowledge not only for the specialists, researchers, academics and the students in this area but for the general public who are concern about the present situation and are interested in knowing about simple non-invasive measures for identifying viral and bacterial infections through their red blood cells.
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Both patients were managed with massage therapy and Strychnine injection and showed clinical recovery after few months [1].
\nGBS is rare but the commonest cause for acute ascending paralytic polynephropathy. GBS is considered to be an acute immune-mediated disorder that causes peripheral polyneuropathy. Most cases of GBS are preceded by either viral or bacterial infection, which triggers the immune system affecting the peripheral nervous system causing a rapid progressive demyelinating polyneuropathy [2, 3].
\nThe incidence of GBS has been increased since the outbreak of certain infections such as Zika virus epidemic in Latin America in 2015. GBS is the most leading cause of acute ascending muscle paralysis with an annual incidence of 1–2 per 100,000 persons per year worldwide. GBS is more common in males than females [2, 3].
\nGBS is a rapid demyelinating peripheral neuropathy that typically manifest as ascending muscle weakness that is symmetric in nature associated with reduced or absent deep tendon reflexes. GBS has been also associated with pain along with sensory impairment [4].
\nGBS is an acute immune-mediated demyelinating polyneuropathy and it is the commonest cause of acute muscle paralysis in pediatric age group patients [5, 6].
\nMFS is a rare neurological disorder which was initially recognized in 1932 by James Collier as a classical triad of ophthalmoplegia, ataxia and absent deep tendon reflexes. Later in 1956 Charles Miller Fisher a Canadian Neurologist described and reported details isolated clinical entity of three patients who presented with ophthalmoplegia, ataxia and areflexia [7].
\nMFS has an annual incidence of 0.9 per 1000,000 populations and affect males more than females at ratio of 2:1 and commonly affect Asian population especially at their fourth decade of life [7].
\nMFS most commonly preceded by Campylobacter jejuni infection and has strong association with positive anti-GQ1b antibodies [7].
\nZika virus infection has been associated with different neurological disorders such as microcephaly and since the initial outbreak of Zika virus infection the number of GBS cases has been increased in endemic countries [8].
\nThe neurological symptoms and signs of GBS usually take place 4 weeks after the initial respiratory or gastrointestinal infection which account for about two-third of GBS cases in adult population. The immune system will be stimulated secondary to infectious antigen with Campylobacter jejuni (C. jejuni) being the most common infectious pathogenic agent which account for 25–50% of adult GBS cases [9]. These infectious antigens cause stimulation of both cellular and hormonal systems leading to axonal damage and demyelination of the peripheral nerve and nerve roots (Figure 1) [11].
\nBasic structure of motor neuron [10].
Monocytes, T-cells, especially CD4+ T-helper cells and B-cells in order of frequency, have been commonly implicated in the immunopathology of GBS cases especially in the acute inflammatory demyelinating polyradiculoneuropathy (AIDP) [11].
\nMore than 80% of the patients with Miller Fisher syndrome have anti-GQ1b IgG antibodies which mainly activate the compliment system especially at the presynaptic nerve ending and perisynaptic Schwann cells which has been implicated in the pathogenesis of MFS [11, 12].
\nGBS is a rapid inflammatory ascending symmetric muscle weakness associated with reduced or complete absent of deep tendon reflexes. The most common symptom is inability to walk. The frequent findings on the clinical examination include hyperesthesia, autonomic dysfunction, sensory loss, ataxia, bilateral facial nerve palsy and third cranial nerve palsy [4, 13].
\nA number of clinical subtypes of Guillain-Barre Syndrome (GBS) are identified.
\nAcute inflammatory demyelinating polyradiculoneuropathy (AIDP) is considered to be the most common subtype and account for approximately of 90 percent of GBS patients in the Unites States. Patients with this subtype typically present with progressive ascending symmetric muscle weakness and areflexia associated with severe pain and autonomic dysfunction such as fluctuation in blood pressure, urinary incontinence or syncope. This clinical subtype typically shows a slow nerve conduction velocity with no clear anti-ganglioside antibodies association [14].
\nOther subtype of GBS is the acute motor axonal neuropathy (AMAN) that accounts for 5% of Guillain-Barre syndrome (GBS) patients in United States. This subtype purely presents with motor weakness without sensory symptoms. Nerve conduction study shows axonal polyneuropathy with normal sensory nerve action potential. Patients with acute motor axonal motor neuropathy have strong association with Campylobacter jejuni (C. jejuni) infection with positive antibodies against gangliosides GM1, GD1a, GaINac-GD1a and GD1b [14].
\nThe acute motor-sensory axonal neuropathy (AMSAN) is a rare and severe variant of GBS [15], which has similar clinical features to acute motor axonal neuropathy but with predominantly sensory loss and positive antibodies against GM1 and GD1a. Nerve conduction study showed axonal polyneuropathy with reduced or absent sensory nerve action potential [14].
\nThe pharyngeal-cervical brachial syndrome (PCB) is another rare subtype of GBS [16]. Patient with PCB syndrome typically present with rapid and progressive oropharyngeal and shoulder muscle weakness associated with absent deep tendon reflexes in the upper limbs. The nerve conduction study in patients with PCB syndrome is generally normal but sometimes showed axonal neuropathy in the arms. PCB syndrome associated with positive IgG anti-GT1a antibodies [17].
\nMiller Fisher syndrome is one of the GBS variant. It is an uncommon neurological disorder which account of about 5% of GBS cases. Patients with Miller Fisher syndrome typically present with clinical trial of ophthalmoplegia which is bilateral symmetric in most patients, ataxia and absent deep tendon reflexes. The commonest initial presenting symptoms in patients with Miller Fisher syndrome is diplopia (double vision) which is due to acute onset-ophthalmoplegia. Other less frequent signs and symptoms of MFS include headache, difficulty swallowing and photophobia (Table 1). MFS is an immune-mediated neurological disorder and more than 80% of patients with MFS showed positive IgG anti-GQ1b antibodies. Electrophysiological findings in patients with MFS commonly showed reduced sensory nerve action potentials and absent H reflexes (Figure 2 and Table 2) [7, 12, 18].
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Clinical symptoms associated with MFS.
Percentage of different subtypes of GBS [14, 18].
Type | \nClinical symptoms | \nElectrophysiological findings | \nSerological tests | \n
---|---|---|---|
Acute inflammatory demyelinating polyradiculoneuropathy | \nMuscle weakness with sensory and autonomic dysfunction | \nSlow nerve conduction velocity | \nNo clear anti-ganglioside antibodies association | \n
Acute motor axonal neuropathy | \nMuscle weakness with no sensory impairment | \nAxonal polyneuropathy with normal sensory nerve action potential | \nPositive anti-ganglioside antibodies GM1, GD1a, GaINac-GD1a, and GD1b | \n
Acute motor-sensory axonal neuropathy | \nMuscle weakness with sensory involvement | \nAxonal polyneuropathy with absent or reduced sensory nerve action potential | \nPositive antibodies against GM1 and GD1a | \n
Pharyngeal-cervical brachial variant | \nOropharyngeal and shoulder muscle weakness | \nGenerally normal, occasional axonal neuropathy in the arms | \nPositive IgG anti-GT1a antibodies | \n
Miller Fisher syndrome | \nOphthalmoplegia, ataxia and areflexia | \nReduced sensory nerve action potential and absent H-reflexes | \nPositive IgG anti-GQ1b antibodies | \n
Summary of the clinical subtypes of Guillain-Barre syndrome.
Bickerstaff brainstem encephalitis currently considered to be another variant of Fisher syndrome associated with central nervous system involvement. Patients with Bickerstaff brainstem encephalitis typically present with ophthalmoplegia, ataxia, hyperreflexia and altered sensorium [19].
\nBickerstaff brainstem encephalitis is an immune-mediated neurological disorder usually preceded by infection and associated with positive anti-GQ1b antibodies [19].
\nZika virus belongs to the virus family Flaviviridae. This virus was first isolated in 1947 from a monkey in the Zika forest of Uganda. Zika virus spread mainly by Aedes mosquitos as well as by intrauterine transmission, blood and sexual intercourse [20]. Most cases of Zika virus infection are associated with mild symptoms such as fever, headache, maculopapular skin rash, red eyes (conjunctivitis) and joint or muscle pain [21, 22, 23].
\nThe outbreak of Zika virus infection in Brazil in 2015 has been associated with a more serious neurological complication such as Guillain-Barre syndrome [24]. This outbreak has been also resulted in increase in the incidence of babies with microcephaly [25, 26].
\nDuring Zika outbreak in Brazil, patients who developed Guillain-Barre syndrome secondary to Zika virus infection were found to have a higher level of anti-ganglioside antibodies of both IgM and IgG isotypes as compared to other patients with Zika infection in the absence of GBS [27].
\nSince Zika virus associated with serious devastating neurological complications such as Guillain-Barre syndrome and congenital anomalies in the newborn babies, several methods have been developed in order to detect the virus in early course of infection. Nonstructural protein 1 (NS1) is considered to be an essential biomarker for early detection and diagnosis of Zika virus. The development of double-antibody sandwich ELISA (DAS-ELISA) has been also used for early and rapid detection of ZIKA-NS1 protein in patients who newly infected with Zika virus [28].
\nAt the present time, there is no antiviral treatment or specific vaccines approved for patients infected with Zika virus. Supportive care remains the main modality of managing these patients, yet the challenge remains to prevent congenital Zika syndrome in pregnant women [29].
\nThe diagnosis of GBS and Miller Fisher variant is often made clinically based on the symptoms and clinical signs of the patients [30]. A more detail and supporting investigational studies such cerebrospinal fluid (CSF) analysis, electrophysiological tests such as nerve conduction studies, ultrasonographic and MRI imaging along with serologic testing can be carried out to confirm the diagnosis of GBS and other variants such as MFS [31].
\nElectrophysiological findings in patients with GBS suggestive of demyelination process in the form of reduce motor conduction velocity (MCV), prolonged motor distal latency and increase F wave latency. The findings of conduction block with absent H-reflex are considered to be the commonest and early sign in GBS [32].
\nPatients with Fisher-Bickerstaff syndrome (FBS) typically showed sensory axonal neuropathy in the form of reduced sensory nerve action potential (SNAP) amplitude in the absence of demyelination parameters [33].
\nThe use of imaging studies such as peripheral nerve ultrasound and MRI are helpful diagnostic tools to diagnose inflammatory peripheral nerve roots [34].
\nThe findings of MRI findings in patients with Miller-Fisher syndrome can range from cranial nerve involvement especially the optic nerve to severe cerebral white matter lesions [35, 36].
\nAnother important biomarker which help confirming the diagnosis of GBS is the cerebrospinal fluid (CSF) analysis which typically show albuminocytologic dissociation (elevated protein level with normal cell count in cerebrospinal fluid) which has been also seen in patients with MFS and Bickerstaff brainstem encephalitis [37].
\nAlthough the diagnosis of MFS is based mainly on the classical trial of ophthalmoplegia, areflexia and ataxia which developed approximately within 1 week to 10 days after the initial infection, serologic tests can be used to confirm the diagnosis. The presence of anti-GQ1b antibodies, which was first described in 1992, provides a strong diagnostic marker for MFS [38].
\nThe yield of this serological marker is high if the test done within 4 weeks after initial clinical onset [39].
\nSince GBS is a demyelinating polyneuropathy that cause rapid ascending muscle paralysis it is vitally important to admit patients with GBS to the intensive care unit for close monitoring and observation as over 30% of GBS patients can develop respiratory failure [40].
\nCurrently plasmapheresis and intravenous immunoglobulin (IVIG) are the only effective therapies for GBS [41].
\nThe timing of plasmapheresis has a significant impact on the clinical outcome if it is done within 2 weeks from the initial clinical onset as it reduces the time needed for ventilator support and improves motor function and walking without any help. The use of IVIG also shown to yield a good response in patients with GBS, however the use of plasmapheresis and IVIG were equally effective in GBS patients and combined therapy showed no significant difference in the final patients’ clinical outcomes as compared to a single therapy. There is no role of corticosteroids therapy in the management of GBS even if it is used in high dose in the initial phase of GBS [40].
\nIn patients with MFS IVIG have shown to speed the recovery of ophthalmoplegia and ataxia. However, IVIG and plasmapheresis have no significant impact on the overall outcome in patients with Miller Fisher syndrome [42].
\nThe overall prognosis of GBS is positive. Not all patients with GBS show complete recovery; however, most of these patients have a good outcome on one year follow up [43].
\nHowever, factors that indicate poor prognosis in GBS patients include old age and severe neurological deficit with cranial nerve injury at clinical onset, the need for mechanical ventilation and axonal damage in the nerve conduction study (Table 3) [44].
\n\n
| \n
Poor prognostic factors in GBS [44].
MFS has an overall a good prognosis [45], and despite the fact it has self-limiting course in most cases, Miller Fisher rarely progressive to respiratory failure [46].
\nThe early diagnosis of MFS and early treatment with plasma exchange or intravenous immunoglobulins can reduce the severity of the disease and hasten the recovery in patients with MFS [46].
\nThe ataxia and ophthalmoplegia usually recover within 1 to 3 months after initial clinical onset with almost complete resolution within 6 months. The loss of deep tendon reflexes may persist however does not interfere with daily functional activities [47].
\nGuillain-Barre syndrome is a serious neurological disorder associated with a rapid progressive ascending muscle paralysis. It is essential to provide maximum supportive medical care and start early therapy to prevent further deterioration and improve the future outcome of the patients.
\nMiller Fisher is a variant of Guillain-Barre syndrome is rare in pediatric population with an overall good prognosis. Early recognition and management of such uncommon neurological disorder will help in preventing further complications and long-term morbidity.
\nThe author declares no conflict of interest.
GBS | Guillain-Barre syndrome |
MFS | Miller Fisher syndrome |
PCB | pharyngeal-cervical brachial |
MRI | magnetic resonance imaging |
IVIG | intravenous immunoglobulin |
ELISA | enzyme-linked immunosorbent assay |
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