Global efficiency of the ITER HNBs and possible injectors for a fusion reactor, based on reduced gas flow into the ion source, improved RF power supplies and a photon neutraliser.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"429",leadTitle:null,fullTitle:"Ferroelectrics - Applications",title:"Ferroelectrics",subtitle:"Applications",reviewType:"peer-reviewed",abstract:"Ferroelectric materials have been and still are widely used in many applications, that have moved from sonar towards breakthrough technologies such as memories or optical devices. This book is a part of a four volume collection (covering material aspects, physical effects, characterization and modeling, and applications) and focuses on the application of ferroelectric devices to innovative systems. In particular, the use of these materials as varying capacitors, gyroscope, acoustics sensors and actuators, microgenerators and memory devices will be exposed, providing an up-to-date review of recent scientific findings and recent advances in the field of ferroelectric devices.",isbn:null,printIsbn:"978-953-307-456-6",pdfIsbn:"978-953-51-4456-4",doi:"10.5772/947",price:119,priceEur:129,priceUsd:155,slug:"ferroelectrics-applications",numberOfPages:264,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:null,bookSignature:"Mickaël Lallart",publishedDate:"August 23rd 2011",coverURL:"https://cdn.intechopen.com/books/images_new/429.jpg",numberOfDownloads:29316,numberOfWosCitations:45,numberOfCrossrefCitations:14,numberOfCrossrefCitationsByBook:12,numberOfDimensionsCitations:42,numberOfDimensionsCitationsByBook:15,hasAltmetrics:0,numberOfTotalCitations:101,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 11th 2010",dateEndSecondStepPublish:"November 8th 2010",dateEndThirdStepPublish:"March 15th 2011",dateEndFourthStepPublish:"April 14th 2011",dateEndFifthStepPublish:"June 13th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"10041",title:"Dr.",name:"Mickaël",middleName:null,surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart",profilePictureURL:"https://mts.intechopen.com/storage/users/10041/images/1517_n.png",biography:"Mickaël Lallart graduated from Institut National des Sciences Appliquées de Lyon (INSA Lyon), Lyon, France, in electrical engineering in 2006, and received his Ph.D. in electronics, electrotechnics, and automatics from the same university in 2008, where he worked for the Laboratoire de Génie Electrique et Ferroélectricité (LGEF). After working as a post-doctoral fellow in the Center for Intelligent Material Systems and Structures (CIMSS) in Virginia Tech, Blacksburg, VA, USA in 2009, Dr. Lallart has been hired as an Associate Professor in the Laboratoire de Génie Electrique et Ferroélectricité. His current field of interest focuses on electroactive materials and their applications, vibration damping, energy harvesting and Structural Health Monitoring, as well as autonomous, self-powered wireless systems.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"Institut National des Sciences Appliquées de Lyon",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"940",title:"Electromagnetism",slug:"metals-and-nonmetals-electromagnetism"}],chapters:[{id:"16172",title:"Giant k31 Relaxor Single-Crystal Plate and Their Applications",doi:"10.5772/19117",slug:"giant-k31-relaxor-single-crystal-plate-and-their-applications",totalDownloads:1927,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Toshio Ogawa",downloadPdfUrl:"/chapter/pdf-download/16172",previewPdfUrl:"/chapter/pdf-preview/16172",authors:[{id:"33684",title:"Prof.",name:"Toshio",surname:"Ogawa",slug:"toshio-ogawa",fullName:"Toshio Ogawa"}],corrections:null},{id:"16173",title:"MEMS Based on Thin Ferroelectric Layers",doi:"10.5772/17539",slug:"mems-based-on-thin-ferroelectric-layers",totalDownloads:1751,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Igor L. Baginsky and Edward G. Kostsov",downloadPdfUrl:"/chapter/pdf-download/16173",previewPdfUrl:"/chapter/pdf-preview/16173",authors:[{id:"28620",title:"Dr.",name:"Igor",surname:"Baginsky",slug:"igor-baginsky",fullName:"Igor Baginsky"},{id:"29271",title:"Prof.",name:"Edward G.",surname:"Kostsov",slug:"edward-g.-kostsov",fullName:"Edward G. Kostsov"}],corrections:null},{id:"16174",title:"Periodically Poled Acoustic Wave-Guide and Transducers for Radio-Frequency Applications",doi:"10.5772/18584",slug:"periodically-poled-acoustic-wave-guide-and-transducers-for-radio-frequency-applications",totalDownloads:2861,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sylvain Ballandras, Emilie Courjon, Florent Bassignot, Gwenn Ulliac, Jérôme Hauden, Julien Garcia, Thierry Laroche and William Daniau",downloadPdfUrl:"/chapter/pdf-download/16174",previewPdfUrl:"/chapter/pdf-preview/16174",authors:[{id:"31933",title:"Dr.",name:"Sylvain",surname:"Ballandras",slug:"sylvain-ballandras",fullName:"Sylvain Ballandras"},{id:"31946",title:"Mr.",name:"Gwenn",surname:"Ulliac",slug:"gwenn-ulliac",fullName:"Gwenn Ulliac"},{id:"31949",title:"Dr.",name:"Emilie",surname:"Courjon",slug:"emilie-courjon",fullName:"Emilie Courjon"},{id:"31950",title:"Mr.",name:"Florent",surname:"Bassignot",slug:"florent-bassignot",fullName:"Florent Bassignot"},{id:"44763",title:"Mr",name:"Jérôme",surname:"Hauden",slug:"jerome-hauden",fullName:"Jérôme Hauden"},{id:"44764",title:"Mr.",name:"Julien",surname:"Garcia",slug:"julien-garcia",fullName:"Julien Garcia"},{id:"44765",title:"Dr.",name:"Thierry",surname:"Laroche",slug:"thierry-laroche",fullName:"Thierry Laroche"},{id:"44766",title:"Mr.",name:"William",surname:"Daniau",slug:"william-daniau",fullName:"William Daniau"}],corrections:null},{id:"16175",title:"Ferroelectric Polymer for Bio-Sonar Replica",doi:"10.5772/16467",slug:"ferroelectric-polymer-for-bio-sonar-replica",totalDownloads:2181,totalCrossrefCites:1,totalDimensionsCites:14,hasAltmetrics:0,abstract:null,signatures:"Antonino S. Fiorillo and Salvatore A. Pullano",downloadPdfUrl:"/chapter/pdf-download/16175",previewPdfUrl:"/chapter/pdf-preview/16175",authors:[{id:"25209",title:"Prof.",name:"Antonino S.",surname:"Fiorillo",slug:"antonino-s.-fiorillo",fullName:"Antonino S. Fiorillo"},{id:"37481",title:"Dr.",name:"Salvatore A.",surname:"Pullano",slug:"salvatore-a.-pullano",fullName:"Salvatore A. Pullano"}],corrections:null},{id:"16176",title:"Ferroelectric Materials for Small-Scale Energy Harvesting Devices and Green Energy Products",doi:"10.5772/23826",slug:"ferroelectric-materials-for-small-scale-energy-harvesting-devices-and-green-energy-products",totalDownloads:3191,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Mickaël Lallart and Daniel Guyomar",downloadPdfUrl:"/chapter/pdf-download/16176",previewPdfUrl:"/chapter/pdf-preview/16176",authors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"},{id:"10042",title:"Prof.",name:"Daniel",surname:"Guyomar",slug:"daniel-guyomar",fullName:"Daniel Guyomar"}],corrections:null},{id:"16177",title:"Future Memory Technology and Ferroelectric Memory as an Ultimate Memory Solution",doi:"10.5772/18550",slug:"future-memory-technology-and-ferroelectric-memory-as-an-ultimate-memory-solution",totalDownloads:3357,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Kinam Kim and Dong Jin Jung",downloadPdfUrl:"/chapter/pdf-download/16177",previewPdfUrl:"/chapter/pdf-preview/16177",authors:[{id:"31826",title:"Dr.",name:"Kinam",surname:"Kim",slug:"kinam-kim",fullName:"Kinam Kim"},{id:"35885",title:"Dr.",name:"Dong Jin",surname:"Jung",slug:"dong-jin-jung",fullName:"Dong Jin Jung"}],corrections:null},{id:"16178",title:"Ultrahigh Density Probe-based Storage Using Ferroelectric Thin Films",doi:"10.5772/17082",slug:"ultrahigh-density-probe-based-storage-using-ferroelectric-thin-films",totalDownloads:1825,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Noureddine Tayebi and Yuegang Zhang",downloadPdfUrl:"/chapter/pdf-download/16178",previewPdfUrl:"/chapter/pdf-preview/16178",authors:[{id:"27195",title:"Dr.",name:"Yuegang",surname:"Zhang",slug:"yuegang-zhang",fullName:"Yuegang Zhang"},{id:"49379",title:"Mr.",name:"Noureddine",surname:"Tayebi",slug:"noureddine-tayebi",fullName:"Noureddine Tayebi"}],corrections:null},{id:"16179",title:"Fabrication and Study on One-Transistor-Capacitor Structure of Nonvolatile Random Access Memory TFT Devices Using Ferroelectric Gated Oxide Film",doi:"10.5772/16405",slug:"fabrication-and-study-on-one-transistor-capacitor-structure-of-nonvolatile-random-access-memory-tft-",totalDownloads:2354,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Chien-Min Cheng, Kai-Huang Chen, Chun-Cheng Lin, Ying-Chung Chen, Chih-Sheng Chen and Ping-Kuan Chang",downloadPdfUrl:"/chapter/pdf-download/16179",previewPdfUrl:"/chapter/pdf-preview/16179",authors:[{id:"24971",title:"Prof.",name:"Kai-Huang",surname:"Chen",slug:"kai-huang-chen",fullName:"Kai-Huang Chen"},{id:"46115",title:"Prof.",name:"Chien-Min",surname:"Cheng",slug:"chien-min-cheng",fullName:"Chien-Min Cheng"},{id:"46116",title:"Mr",name:"Chih-sheng",surname:"Chen",slug:"chih-sheng-chen",fullName:"Chih-sheng Chen"},{id:"46117",title:"Mr",name:"Ping-Kuan",surname:"Chang",slug:"ping-kuan-chang",fullName:"Ping-Kuan Chang"},{id:"46118",title:"Prof.",name:"Ying-Chung",surname:"Chen",slug:"ying-chung-chen",fullName:"Ying-Chung Chen"}],corrections:null},{id:"16180",title:"Ferroelectric Copolymer-Based Plastic Memory Transistors",doi:"10.5772/17547",slug:"ferroelectric-copolymer-based-plastic-memory-transistors",totalDownloads:3601,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sung-Min Yoon, Shinhyuk Yang, Soon-Won Jung, Sang-Hee Ko Park, Chun-Won Byun, Min-Ki Ryu, Himchan Oh, Chi-Sun Hwang, Kyoung-Ik Cho and Byoung-Gon Yu",downloadPdfUrl:"/chapter/pdf-download/16180",previewPdfUrl:"/chapter/pdf-preview/16180",authors:[{id:"28648",title:"Dr.",name:"Sung-Min",surname:"Yoon",slug:"sung-min-yoon",fullName:"Sung-Min Yoon"},{id:"37549",title:"Mr.",name:"Shinhyuk",surname:"Yang",slug:"shinhyuk-yang",fullName:"Shinhyuk Yang"},{id:"37550",title:"Dr.",name:"Soon-Won",surname:"Jung",slug:"soon-won-jung",fullName:"Soon-Won Jung"},{id:"37551",title:"Dr.",name:"Sang-Hee",surname:"Ko Park",slug:"sang-hee-ko-park",fullName:"Sang-Hee Ko Park"},{id:"37552",title:"Mr.",name:"Chun-Won",surname:"Byun",slug:"chun-won-byun",fullName:"Chun-Won Byun"},{id:"37553",title:"Dr.",name:"Min-Ki",surname:"Ryu",slug:"min-ki-ryu",fullName:"Min-Ki Ryu"},{id:"37554",title:"Mr.",name:"Himchan",surname:"Oh",slug:"himchan-oh",fullName:"Himchan Oh"},{id:"37555",title:"Dr.",name:"Chi-Sun",surname:"Hwang",slug:"chi-sun-hwang",fullName:"Chi-Sun Hwang"},{id:"37556",title:"Dr.",name:"Kyoung-Ik",surname:"Cho",slug:"kyoung-ik-cho",fullName:"Kyoung-Ik Cho"},{id:"37557",title:"Dr.",name:"Byoung-Gon",surname:"Yu",slug:"byoung-gon-yu",fullName:"Byoung-Gon Yu"}],corrections:null},{id:"16181",title:"Use of FRAM Memories in Spacecrafts",doi:"10.5772/18529",slug:"use-of-fram-memories-in-spacecrafts",totalDownloads:3611,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Claudio Sansoè and Maurizio Tranchero",downloadPdfUrl:"/chapter/pdf-download/16181",previewPdfUrl:"/chapter/pdf-preview/16181",authors:[{id:"5017",title:"Dr.",name:"Maurizio",surname:"Tranchero",slug:"maurizio-tranchero",fullName:"Maurizio Tranchero"},{id:"31776",title:"Dr.",name:"Maurizio",surname:"Tranchero",slug:"maurizio-tranchero",fullName:"Maurizio Tranchero"},{id:"37705",title:"Dr.",name:"Claudio",surname:"Sansoe",slug:"claudio-sansoe",fullName:"Claudio Sansoe"}],corrections:null},{id:"16182",title:"Adaptive Boolean Logic Using Ferroelectrics Capacitors as Basic Units of Artificial Neurons",doi:"10.5772/17810",slug:"adaptive-boolean-logic-using-ferroelectrics-capacitors-as-basic-units-of-artificial-neurons",totalDownloads:2657,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Alan P. O. da Silva, Cicília R. M. Leite, Ana M. G. Guerreiro, Carlos A. Paz de Araujo and Larry McMillan",downloadPdfUrl:"/chapter/pdf-download/16182",previewPdfUrl:"/chapter/pdf-preview/16182",authors:[{id:"13073",title:"MSc",name:"Cicília",surname:"Maia Leite",slug:"cicilia-maia-leite",fullName:"Cicília Maia Leite"},{id:"29519",title:"Dr.",name:"Ana",surname:"Guerreiro",slug:"ana-guerreiro",fullName:"Ana Guerreiro"},{id:"38796",title:"MSc.",name:"Alan",surname:"Silva",slug:"alan-silva",fullName:"Alan Silva"},{id:"38797",title:"Dr.",name:"Larry",surname:"McMillan",slug:"larry-mcmillan",fullName:"Larry McMillan"},{id:"38798",title:"Dr.",name:"Carlos",surname:"Araujo",slug:"carlos-araujo",fullName:"Carlos Araujo"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"424",title:"Ferroelectrics",subtitle:"Physical Effects",isOpenForSubmission:!1,hash:"d9d8a531dfb92ccd58e2a8b9a426dcd4",slug:"ferroelectrics-physical-effects",bookSignature:"Mickaël Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/424.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"174",title:"Ferroelectrics",subtitle:"Material Aspects",isOpenForSubmission:!1,hash:"4489eb7544dc5c1014f4e1280e677371",slug:"ferroelectrics-material-aspects",bookSignature:"Mickaël Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/174.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"428",title:"Ferroelectrics",subtitle:"Characterization and Modeling",isOpenForSubmission:!1,hash:null,slug:"ferroelectrics-characterization-and-modeling",bookSignature:"Mickaël Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/428.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2706",title:"Small-Scale Energy Harvesting",subtitle:null,isOpenForSubmission:!1,hash:"63bc4c27bdf9ec1e00aa20ff6f1d804f",slug:"small-scale-energy-harvesting",bookSignature:"Mickael Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/2706.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3664",title:"Vibration Control",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"vibration-control",bookSignature:"Mickael Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/3664.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5514",title:"Magnetic Spinels",subtitle:"Synthesis, Properties and Applications",isOpenForSubmission:!1,hash:"c3c43611e3fb0a8ab988acc896eae935",slug:"magnetic-spinels-synthesis-properties-and-applications",bookSignature:"Mohindar Singh Seehra",coverURL:"https://cdn.intechopen.com/books/images_new/5514.jpg",editedByType:"Edited by",editors:[{id:"48086",title:"Prof.",name:"Mohindar",surname:"Seehra",slug:"mohindar-seehra",fullName:"Mohindar Seehra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1873",title:"Advanced Magnetic Materials",subtitle:null,isOpenForSubmission:!1,hash:"24a0c00844ead5d9264572db1b120866",slug:"advanced-magnetic-materials",bookSignature:"Leszek Malkinski",coverURL:"https://cdn.intechopen.com/books/images_new/1873.jpg",editedByType:"Edited by",editors:[{id:"115596",title:"Dr.",name:"Leszek",surname:"Malkinski",slug:"leszek-malkinski",fullName:"Leszek Malkinski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3210",title:"Advances in Ferroelectrics",subtitle:null,isOpenForSubmission:!1,hash:"4706ad2bc11c32090c362c0026f67d37",slug:"advances-in-ferroelectrics",bookSignature:"Aimé Peláiz Barranco",coverURL:"https://cdn.intechopen.com/books/images_new/3210.jpg",editedByType:"Edited by",editors:[{id:"14679",title:"Dr.",name:"Aimé",surname:"Peláiz-Barranco",slug:"aime-pelaiz-barranco",fullName:"Aimé Peláiz-Barranco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6198",title:"Magnetism and Magnetic Materials",subtitle:null,isOpenForSubmission:!1,hash:"ccf0a4d8e8e42ef4e29f805286ab43f9",slug:"magnetism-and-magnetic-materials",bookSignature:"Neeraj Panwar",coverURL:"https://cdn.intechopen.com/books/images_new/6198.jpg",editedByType:"Edited by",editors:[{id:"289829",title:"Dr.",name:"Neeraj",surname:"Panwar",slug:"neeraj-panwar",fullName:"Neeraj Panwar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8653",title:"Electromagnetic Materials and Devices",subtitle:null,isOpenForSubmission:!1,hash:"0cc0489a203ae888b1105719a4e70ecd",slug:"electromagnetic-materials-and-devices",bookSignature:"Man-Gui Han",coverURL:"https://cdn.intechopen.com/books/images_new/8653.jpg",editedByType:"Edited by",editors:[{id:"250649",title:"Prof.",name:"Man-Gui",surname:"Han",slug:"man-gui-han",fullName:"Man-Gui Han"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"erratum-covid-19-transmission-in-children-implications-for",title:"Erratum: COVID-19 Transmission in Children: Implications for Schools",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/78823.pdf",downloadPdfUrl:"/chapter/pdf-download/78823",previewPdfUrl:"/chapter/pdf-preview/78823",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/78823",risUrl:"/chapter/ris/78823",chapter:{id:"77986",slug:"covid-19-transmission-in-children-implications-for-schools",signatures:"Evelyn Mendoza-Torres, Franklin Torres, Wendy Rosales-Rada, Liliana Encinales, Lil Avendaño, María Fernanda Pérez, Ivana Terán, David Vergara, Estefanie Osorio-Llanes, Paige Fierbaugh, Wendy Villamizar, Aileen Y. Chang and Jairo Castellar-Lopez",dateSubmitted:"June 15th 2021",dateReviewed:"July 12th 2021",datePrePublished:"September 13th 2021",datePublished:"March 16th 2022",book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"342716",title:"Assistant Prof.",name:"Aileen",middleName:null,surname:"Y. Chang",fullName:"Aileen Y. Chang",slug:"aileen-y.-chang",email:"chang@email.gwu.edu",position:null,institution:null},{id:"342718",title:"Dr.",name:"Evelyn",middleName:null,surname:"Mendoza-Torres",fullName:"Evelyn Mendoza-Torres",slug:"evelyn-mendoza-torres",email:"evelyn.mendozat@unilibre.edu.co",position:null,institution:{name:"Free University of Colombia",institutionURL:null,country:{name:"Colombia"}}},{id:"427633",title:"Dr.",name:"Franklin",middleName:null,surname:"Torres",fullName:"Franklin Torres",slug:"franklin-torres",email:"dummy+427633@intechopen.com",position:null,institution:null},{id:"427634",title:"Dr.",name:"Wendy",middleName:null,surname:"Rosales-Rada",fullName:"Wendy Rosales-Rada",slug:"wendy-rosales-rada",email:"dummy+427634@intechopen.com",position:null,institution:null},{id:"427635",title:"Dr.",name:"Liliana",middleName:null,surname:"Encinales",fullName:"Liliana Encinales",slug:"liliana-encinales",email:"dummy+427635@intechopen.com",position:null,institution:null},{id:"427636",title:"Dr.",name:"Lil",middleName:null,surname:"Avendaño",fullName:"Lil Avendaño",slug:"lil-avendano",email:"dummy+427636@intechopen.com",position:null,institution:null},{id:"427637",title:"Dr.",name:"María Fernanda",middleName:null,surname:"Pérez",fullName:"María Fernanda Pérez",slug:"maria-fernanda-perez",email:"dummy+427637@intechopen.com",position:null,institution:null},{id:"427638",title:"Dr.",name:"Ivana",middleName:null,surname:"Terán",fullName:"Ivana Terán",slug:"ivana-teran",email:"dummy+427638@intechopen.com",position:null,institution:null},{id:"427639",title:"Dr.",name:"David",middleName:null,surname:"Vergara",fullName:"David Vergara",slug:"david-vergara",email:"dummy+427639@intechopen.com",position:null,institution:null},{id:"427640",title:"Dr.",name:"Estefanie",middleName:null,surname:"Osorio-Llanes",fullName:"Estefanie Osorio-Llanes",slug:"estefanie-osorio-llanes",email:"dummy+427640@intechopen.com",position:null,institution:null},{id:"427641",title:"Dr.",name:"Paige",middleName:null,surname:"Fierbaugh",fullName:"Paige Fierbaugh",slug:"paige-fierbaugh",email:"dummy+427641@intechopen.com",position:null,institution:null},{id:"427642",title:"Dr.",name:"Wendy",middleName:null,surname:"Villamizar",fullName:"Wendy Villamizar",slug:"wendy-villamizar",email:"dummy+427642@intechopen.com",position:null,institution:null},{id:"457495",title:"Dr.",name:"Jairo",middleName:null,surname:"Castellar-Lopez",fullName:"Jairo Castellar-Lopez",slug:"jairo-castellar-lopez",email:"dummy+427643@intechopen.com",position:null,institution:null}]}},chapter:{id:"77986",slug:"covid-19-transmission-in-children-implications-for-schools",signatures:"Evelyn Mendoza-Torres, Franklin Torres, Wendy Rosales-Rada, Liliana Encinales, Lil Avendaño, María Fernanda Pérez, Ivana Terán, David Vergara, Estefanie Osorio-Llanes, Paige Fierbaugh, Wendy Villamizar, Aileen Y. Chang and Jairo Castellar-Lopez",dateSubmitted:"June 15th 2021",dateReviewed:"July 12th 2021",datePrePublished:"September 13th 2021",datePublished:"March 16th 2022",book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"342716",title:"Assistant Prof.",name:"Aileen",middleName:null,surname:"Y. Chang",fullName:"Aileen Y. Chang",slug:"aileen-y.-chang",email:"chang@email.gwu.edu",position:null,institution:null},{id:"342718",title:"Dr.",name:"Evelyn",middleName:null,surname:"Mendoza-Torres",fullName:"Evelyn Mendoza-Torres",slug:"evelyn-mendoza-torres",email:"evelyn.mendozat@unilibre.edu.co",position:null,institution:{name:"Free University of Colombia",institutionURL:null,country:{name:"Colombia"}}},{id:"427633",title:"Dr.",name:"Franklin",middleName:null,surname:"Torres",fullName:"Franklin Torres",slug:"franklin-torres",email:"dummy+427633@intechopen.com",position:null,institution:null},{id:"427634",title:"Dr.",name:"Wendy",middleName:null,surname:"Rosales-Rada",fullName:"Wendy Rosales-Rada",slug:"wendy-rosales-rada",email:"dummy+427634@intechopen.com",position:null,institution:null},{id:"427635",title:"Dr.",name:"Liliana",middleName:null,surname:"Encinales",fullName:"Liliana Encinales",slug:"liliana-encinales",email:"dummy+427635@intechopen.com",position:null,institution:null},{id:"427636",title:"Dr.",name:"Lil",middleName:null,surname:"Avendaño",fullName:"Lil Avendaño",slug:"lil-avendano",email:"dummy+427636@intechopen.com",position:null,institution:null},{id:"427637",title:"Dr.",name:"María Fernanda",middleName:null,surname:"Pérez",fullName:"María Fernanda Pérez",slug:"maria-fernanda-perez",email:"dummy+427637@intechopen.com",position:null,institution:null},{id:"427638",title:"Dr.",name:"Ivana",middleName:null,surname:"Terán",fullName:"Ivana Terán",slug:"ivana-teran",email:"dummy+427638@intechopen.com",position:null,institution:null},{id:"427639",title:"Dr.",name:"David",middleName:null,surname:"Vergara",fullName:"David Vergara",slug:"david-vergara",email:"dummy+427639@intechopen.com",position:null,institution:null},{id:"427640",title:"Dr.",name:"Estefanie",middleName:null,surname:"Osorio-Llanes",fullName:"Estefanie Osorio-Llanes",slug:"estefanie-osorio-llanes",email:"dummy+427640@intechopen.com",position:null,institution:null},{id:"427641",title:"Dr.",name:"Paige",middleName:null,surname:"Fierbaugh",fullName:"Paige Fierbaugh",slug:"paige-fierbaugh",email:"dummy+427641@intechopen.com",position:null,institution:null},{id:"427642",title:"Dr.",name:"Wendy",middleName:null,surname:"Villamizar",fullName:"Wendy Villamizar",slug:"wendy-villamizar",email:"dummy+427642@intechopen.com",position:null,institution:null},{id:"457495",title:"Dr.",name:"Jairo",middleName:null,surname:"Castellar-Lopez",fullName:"Jairo Castellar-Lopez",slug:"jairo-castellar-lopez",email:"dummy+427643@intechopen.com",position:null,institution:null}]},book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"10479",leadTitle:null,title:"21st Century Advanced Carbon Materials for Engineering Applications",subtitle:"A Comprehensive Handbook",reviewType:"peer-reviewed",abstract:"Advanced carbon materials such as graphene, fullerenes, hierarchical carbon, and carbon nanotubes (CNTs) have exceptional physical properties, making them useful for several applications in fields ranging from energy and industry to electronics and drug delivery. This book includes comprehensive information on fabrication, emerging physical properties, and technological applications of advanced carbon materials. Over three sections, chapters cover such topics as advanced carbon materials in engineering, conjugation of graphene with other 2D materials, fabrication of CNTs and their use in tissue engineering and orthopaedics, and advanced carbon materials for sustainable applications, among others.",isbn:"978-1-78985-924-9",printIsbn:"978-1-78985-912-6",pdfIsbn:"978-1-78985-991-1",doi:"10.5772/intechopen.92494",price:119,priceEur:129,priceUsd:155,slug:"21st-century-advanced-carbon-materials-for-engineering-applications-a-comprehensive-handbook",numberOfPages:130,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"712d04d43dbe1dca7dec9fcc08bc8852",bookSignature:"Mujtaba Ikram and Asghari Maqsood",publishedDate:"October 13th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10479.jpg",keywords:null,numberOfDownloads:1994,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfDimensionsCitations:11,numberOfTotalCitations:15,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 28th 2020",dateEndSecondStepPublish:"September 25th 2020",dateEndThirdStepPublish:"November 24th 2020",dateEndFourthStepPublish:"February 12th 2021",dateEndFifthStepPublish:"April 13th 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:"A visiting scholar at the Abdus Salam International Center for Theoretical Physics (ICTP)-Italy from time to time, Dr. Ikram was selected among two young scientists from South Asia for TWAS science diplomacy, which was held in Trieste Italy 2013 and in 2015, he was also awarded CAS-TWAS green technology award followed by CAS-TWAS green chemistry and technology (GCT) award for his guest lectures in 2017.",coeditorOneBiosketch:"A dean of the Faculty of Basics and Applied Sciences, Air University, Islamabad, Pakistan with over 40 years of experience in research of advanced materials. Prof. Maqsood has 212 research publications, including 180 journal publications and 4 book chapters. She is a receiver of many national and international awards and is recognized widely for her scientific work.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"286820",title:"Dr.",name:"Mujtaba",middleName:null,surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bReopQAC/Profile_Picture_1636383457578",biography:"Dr. Mujtaba Ikram has obtained his BS hons. (computational physics), MS (materials and surface engineering) and Ph.D. (material sciences and engineering), respectively. His research interests include nanotechnology, renewable energy, material science and engineering. His work has been cited by scientists from all over the world. He has authored/co- authored number of publications with 100+ cumulative impact factor in world prestigious journals as Advanced materials, RSC advances, Journal of Materials Chemistry C, RSC New Journal of chemistry, Chemcatchem, Journal of alloys and compounds, Applied nanoscience, International Journal of hydrogen energy, Journal of physics and chemistry of solids, Journals of solid state chemistry and many others. He has represented his research in the USA, Italy, Egypt, Germany, Slovenia, China, Hong Kong, Malaysia, UAE and many other countries. He has attended various research training/conferences/workshops on industrial physics, renewable energy, advanced carbon materials and nanotechnology in various parts of the world. He is a frequent visiting scholar at the Abdus Salam International center for theoretical physics (ICTP)-Italy. He has attended training on renewable and sustainable energy, which was organized by world prestigious national renewable energy lab (NREL)-USA and university of colorado at boulder-USA. He has attended AIP Industrial physics forum, ICTP- UNESCO-Italy conferences on energy co sponsored by American Institute of Physics (AIP), I-CAMP-colorado conference-USA, International conference on nanotechnology, biotechnology and spectroscopy (ICNBS)-Egypt, TWAS Energy science diplomacy Conference-Italy, International conference on advanced carbon Materials-Jinan-China and International ICTP nanosystems workshop-Italy. He was selected among two young scientists from south Asia for TWAS science diplomacy, which was held in Trieste Italy, 2013. He has been invited many times as Invited lecturer by CAS-TWAS Beijing. In 2015, he was awarded with CAS-TWAS green technology award. In 2017, he was awarded with CAS-TWAS green chemistry and technology (GCT) award for his guest lectures. He has been awarded with various world prestigious fellowships as CAS- TWAS presidential fellowship 2014, I-CAMP University of Colorado at boulder (USA) fellowship 2012, International center for theoretical physics (ICTP-Italy) participant fellowship (thrice), UNESCO fellowship for nano system workshop (Italy) 2013, Intercontinental advanced materials and photonics university of Cambridge (UK) participant fellowship 2013, Emerging nation science foundation (ENSF) travel fellowship 2012 and NUST foreign research presentation grant 2012.",institutionString:"University of the Punjab",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of the Punjab",institutionURL:null,country:{name:"Pakistan"}}}],coeditorOne:{id:"321219",title:"Dr.",name:"Asghari",middleName:null,surname:"Maqsood",slug:"asghari-maqsood",fullName:"Asghari Maqsood",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002w6QhQQAU/Profile_Picture_1636447379567",biography:"Professor Emeritus Dr Asghari Maqsood is currently working as an advisor to the vice-chancellor, Air University, Islamabad, Pakistan, where she also served as a founding dean in the Faculty of Basics and Applied Sciences. She has more than forty-eight years of experience in the research of advanced materials. She obtained her MSc from Oxford University, and Ph.D. in Materials Science from Goteborg University, Sweden, along with a diploma from Uppsala University, Sweden. She has more than 250 research publications to her credit including more than 230 journal publications and 4 books, 5 chapters and one edited book.\r\nShe has arranged many international and national conferences and has presented her work as an invited speaker internationally in Bangladesh, China, Iran, Malaysia, Singapore, Sri Lanka, United Kingdom etc. She has been awarded many national and international awards including a Gold Medal from the Pakistan Academy of Sciences (2000), President’s Award for Pride of Performance (2001), HEC Best University Teacher Award (2002), Prime Minister Gold Medal (2004), Izaz-i-Fazeelat for Academic Distinction (2005), and Civil Award Sitara- e- Imtiaz (2010). Professor Maqsood is a fellow of Pakistan Academy of Sciences and Pakistan Nuclear Society. She has supervised more than 130 post graduate theses. Recently, her name appeared among the world's top 2% of scientists on a list by Stanford University, California, USA.",institutionString:"Air University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Air University",institutionURL:null,country:{name:"Pakistan"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"208",title:"Material Science",slug:"nanotechnology-and-nanomaterials-material-science"}],chapters:[{id:"74964",title:"Introductory Chapter: Introduction to Advanced Carbon Materials and Innovative Engineering Applications",slug:"introductory-chapter-introduction-to-advanced-carbon-materials-and-innovative-engineering-applicatio",totalDownloads:200,totalCrossrefCites:0,authors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"},{id:"321219",title:"Dr.",name:"Asghari",surname:"Maqsood",slug:"asghari-maqsood",fullName:"Asghari Maqsood"},{id:"325636",title:"Prof.",name:"Abdullah Khan",surname:"Durrani",slug:"abdullah-khan-durrani",fullName:"Abdullah Khan Durrani"},{id:"329337",title:"Dr.",name:"Sana",surname:"Arbab",slug:"sana-arbab",fullName:"Sana Arbab"},{id:"343632",title:"Prof.",name:"Khurram",surname:"Shahzad",slug:"khurram-shahzad",fullName:"Khurram Shahzad"},{id:"345882",title:"Dr.",name:"Sadia",surname:"Sharif",slug:"sadia-sharif",fullName:"Sadia Sharif"},{id:"345883",title:"Ms.",name:"Amna",surname:"Saeed",slug:"amna-saeed",fullName:"Amna Saeed"},{id:"345884",title:"Mr.",name:"Muhammad Aamir",surname:"Iqbal",slug:"muhammad-aamir-iqbal",fullName:"Muhammad Aamir Iqbal"}]},{id:"74947",title:"Advanced Carbon Materials: Base of 21st Century Scientific Innovations in Chemical, Polymer, Sensing and Energy Engineering",slug:"advanced-carbon-materials-base-of-21st-century-scientific-innovations-in-chemical-polymer-sensing-an",totalDownloads:309,totalCrossrefCites:2,authors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"},{id:"321219",title:"Dr.",name:"Asghari",surname:"Maqsood",slug:"asghari-maqsood",fullName:"Asghari Maqsood"},{id:"325636",title:"Prof.",name:"Abdullah Khan",surname:"Durrani",slug:"abdullah-khan-durrani",fullName:"Abdullah Khan Durrani"},{id:"343632",title:"Prof.",name:"Khurram",surname:"Shahzad",slug:"khurram-shahzad",fullName:"Khurram Shahzad"},{id:"325637",title:"Dr.",name:"Muhammad",surname:"Ikram",slug:"muhammad-ikram",fullName:"Muhammad Ikram"},{id:"342880",title:"Dr.",name:"Ali",surname:"Haider",slug:"ali-haider",fullName:"Ali Haider"},{id:"342882",title:"Mr.",name:"Junaid",surname:"Haider",slug:"junaid-haider",fullName:"Junaid Haider"},{id:"343631",title:"Dr.",name:"Ali",surname:"Raza",slug:"ali-raza",fullName:"Ali Raza"},{id:"343633",title:"Dr.",name:"Asim Hassan",surname:"Rizvi",slug:"asim-hassan-rizvi",fullName:"Asim Hassan Rizvi"}]},{id:"76289",title:"Carbon Nanotubes Integrated Hydroxyapatite Nano-Composite for Orthopaedic and Tissue Engineering Applications",slug:"carbon-nanotubes-integrated-hydroxyapatite-nano-composite-for-orthopaedic-and-tissue-engineering-app",totalDownloads:280,totalCrossrefCites:0,authors:[{id:"281461",title:"Ph.D.",name:"Khalid",surname:"Parwez",slug:"khalid-parwez",fullName:"Khalid Parwez"}]},{id:"78704",title:"Advanced Carbon Materials for Sustainable and Emerging Applications",slug:"advanced-carbon-materials-for-sustainable-and-emerging-applications",totalDownloads:250,totalCrossrefCites:0,authors:[{id:"435073",title:"Dr.",name:"Aneeqa",surname:"Bashir",slug:"aneeqa-bashir",fullName:"Aneeqa Bashir"},{id:"435075",title:"Dr.",name:"Azka",surname:"Mehvish",slug:"azka-mehvish",fullName:"Azka Mehvish"},{id:"435076",title:"Dr.",name:"Maria",surname:"Khalil",slug:"maria-khalil",fullName:"Maria Khalil"}]},{id:"74312",title:"Electrochemical Exfoliation of 2D Advanced Carbon Derivatives",slug:"electrochemical-exfoliation-of-2d-advanced-carbon-derivatives",totalDownloads:550,totalCrossrefCites:2,authors:[{id:"325637",title:"Dr.",name:"Muhammad",surname:"Ikram",slug:"muhammad-ikram",fullName:"Muhammad Ikram"},{id:"337345",title:"MSc.",name:"Ali",surname:"Raza",slug:"ali-raza",fullName:"Ali Raza"},{id:"337401",title:"Mr.",name:"Sarfraz",surname:"Ali",slug:"sarfraz-ali",fullName:"Sarfraz Ali"},{id:"337402",title:"Prof.",name:"Salamat",surname:"Ali",slug:"salamat-ali",fullName:"Salamat Ali"}]},{id:"74549",title:"Carbon Nanotubes",slug:"carbon-nanotubes",totalDownloads:405,totalCrossrefCites:0,authors:[{id:"325637",title:"Dr.",name:"Muhammad",surname:"Ikram",slug:"muhammad-ikram",fullName:"Muhammad Ikram"},{id:"342880",title:"Dr.",name:"Ali",surname:"Haider",slug:"ali-haider",fullName:"Ali Haider"},{id:"342882",title:"Mr.",name:"Junaid",surname:"Haider",slug:"junaid-haider",fullName:"Junaid Haider"},{id:"337345",title:"MSc.",name:"Ali",surname:"Raza",slug:"ali-raza",fullName:"Ali Raza"},{id:"337401",title:"Mr.",name:"Sarfraz",surname:"Ali",slug:"sarfraz-ali",fullName:"Sarfraz Ali"},{id:"337402",title:"Prof.",name:"Salamat",surname:"Ali",slug:"salamat-ali",fullName:"Salamat Ali"},{id:"342877",title:"Dr.",name:"Atif",surname:"Shahbaz",slug:"atif-shahbaz",fullName:"Atif Shahbaz"},{id:"342878",title:"Ms.",name:"Haleema",surname:"Ijaz",slug:"haleema-ijaz",fullName:"Haleema Ijaz"},{id:"342881",title:"Mr.",name:"M Tayyab",surname:"Hussain",slug:"m-tayyab-hussain",fullName:"M Tayyab Hussain"},{id:"342883",title:"Mr.",name:"Arsalan",surname:"Ahmed Rafi",slug:"arsalan-ahmed-rafi",fullName:"Arsalan Ahmed Rafi"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"7640",title:"Perspective of Carbon Nanotubes",subtitle:null,isOpenForSubmission:!1,hash:"8b85a9957fad5206369eadf0c1ffa27d",slug:"perspective-of-carbon-nanotubes",bookSignature:"Hosam El-Din Saleh and Said Moawad Mohamed El-Sheikh",coverURL:"https://cdn.intechopen.com/books/images_new/7640.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6408",title:"Novel Nanomaterials",subtitle:"Synthesis and Applications",isOpenForSubmission:!1,hash:"f3585d338d78e4d31c200d9991b03692",slug:"novel-nanomaterials-synthesis-and-applications",bookSignature:"George Z. Kyzas and Athanasios C. Mitropoulos",coverURL:"https://cdn.intechopen.com/books/images_new/6408.jpg",editedByType:"Edited by",editors:[{id:"152296",title:"Prof.",name:"George",surname:"Kyzas",slug:"george-kyzas",fullName:"George Kyzas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6833",title:"Chemical Vapor Deposition for Nanotechnology",subtitle:null,isOpenForSubmission:!1,hash:"31d2b0b2a437691b6a657030687b0096",slug:"chemical-vapor-deposition-for-nanotechnology",bookSignature:"Pietro Mandracci",coverURL:"https://cdn.intechopen.com/books/images_new/6833.jpg",editedByType:"Edited by",editors:[{id:"80989",title:"Prof.",name:"Pietro",surname:"Mandracci",slug:"pietro-mandracci",fullName:"Pietro Mandracci"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6326",title:"Novel Aspects of Nanofibers",subtitle:null,isOpenForSubmission:!1,hash:"6585d128fb06c600192cc380a8eec4cb",slug:"novel-aspects-of-nanofibers",bookSignature:"Tong Lin",coverURL:"https://cdn.intechopen.com/books/images_new/6326.jpg",editedByType:"Edited by",editors:[{id:"49937",title:"Dr.",name:"Tong",surname:"Lin",slug:"tong-lin",fullName:"Tong Lin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6501",title:"Electrospinning Method Used to Create Functional Nanocomposites Films",subtitle:null,isOpenForSubmission:!1,hash:"c28620c5ccc64e4b32eb9758302a1679",slug:"electrospinning-method-used-to-create-functional-nanocomposites-films",bookSignature:"Tomasz Tański, Pawel Jarka and Wiktor Matysiak",coverURL:"https://cdn.intechopen.com/books/images_new/6501.jpg",editedByType:"Edited by",editors:[{id:"15700",title:"Prof.",name:"Tomasz Arkadiusz",surname:"Tański",slug:"tomasz-arkadiusz-tanski",fullName:"Tomasz Arkadiusz Tański"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7554",title:"Functional Materials",subtitle:null,isOpenForSubmission:!1,hash:"5519dce9bc7d81f85ac967824eb508b8",slug:"functional-materials",bookSignature:"Dipti Sahu",coverURL:"https://cdn.intechopen.com/books/images_new/7554.jpg",editedByType:"Edited by",editors:[{id:"251855",title:"Prof.",name:"Dipti Ranjan",surname:"Sahu",slug:"dipti-ranjan-sahu",fullName:"Dipti Ranjan Sahu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6218",title:"Carbon Nanotubes",subtitle:"Recent Progress",isOpenForSubmission:!1,hash:"9f38af20209e9d816b7d57ecbba386b9",slug:"carbon-nanotubes-recent-progress",bookSignature:"Mohammed Muzibur Rahman and Abdullah Mohamed Asiri",coverURL:"https://cdn.intechopen.com/books/images_new/6218.jpg",editedByType:"Edited by",editors:[{id:"24438",title:"Prof.",name:"Mohammed Muzibur",surname:"Rahman",slug:"mohammed-muzibur-rahman",fullName:"Mohammed Muzibur Rahman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10072",title:"Nanotechnology and the Environment",subtitle:null,isOpenForSubmission:!1,hash:"f68ba7ccb7700868a54c347421f572fb",slug:"nanotechnology-and-the-environment",bookSignature:"Mousumi Sen",coverURL:"https://cdn.intechopen.com/books/images_new/10072.jpg",editedByType:"Edited by",editors:[{id:"310218",title:"Dr.",name:"Mousumi",surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7649",title:"Nanorods and Nanocomposites",subtitle:null,isOpenForSubmission:!1,hash:"4ec1066a1d642f736d04932ded52ab44",slug:"nanorods-and-nanocomposites",bookSignature:"Morteza Sasani Ghamsari and Soumen Dhara",coverURL:"https://cdn.intechopen.com/books/images_new/7649.jpg",editedByType:"Edited by",editors:[{id:"64949",title:"Prof.",name:"Morteza",surname:"Sasani Ghamsari",slug:"morteza-sasani-ghamsari",fullName:"Morteza Sasani Ghamsari"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7684",title:"Multilayer Thin Films",subtitle:"Versatile Applications for Materials Engineering",isOpenForSubmission:!1,hash:"fd04577df0c895320c3f06d98308ea67",slug:"multilayer-thin-films-versatile-applications-for-materials-engineering",bookSignature:"Sukumar Basu",coverURL:"https://cdn.intechopen.com/books/images_new/7684.jpg",editedByType:"Edited by",editors:[{id:"50632",title:"Prof.",name:"Sukumar",surname:"Basu",slug:"sukumar-basu",fullName:"Sukumar Basu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"68732",title:"Research, Design, and Development Needed to Realise a Neutral Beam Injection System for a Fusion Reactor",doi:"10.5772/intechopen.88724",slug:"research-design-and-development-needed-to-realise-a-neutral-beam-injection-system-for-a-fusion-react",body:'
A neutral beam system on a fusion reactor will have to meet specifications that are significantly beyond those of any system so far designed. The injectors will be directly connected to the reactor vessel, and therefore they will both form a part of the nuclear confinement barrier and be subjected to high levels of neutron and gamma radiation. Consequently, the injector design must include a radiation barrier around the injectors; the choice of materials that can be used must be acceptable to the vacuum environment, be radiation tolerant, and, where possible, be low-activation materials. In addition, the design will have to satisfy the nuclear regulator, which, typically, limits the engineering design codes that can be used.
It is clear that the main factors that will influence the design of the injectors, and require R&D, are the pulse length, the global efficiency, operation and maintenance in a nuclear environment, and component lifetime. In the following sections of this chapter, each of the aforementioned aspects is discussed more in detail and some suggestions given as to how problems arising from each aspect may be resolved and the parameters of the future injectors achieved. However it is important to understand that although various basic conceptual designs of an injector to be used on a fusion reactor have been considered [1, 2, 3], no concept has been chosen, and no serious engineering design of any concept has been carried out. Experience with the design of the neutral beam systems has shown that many aspects of the conceptual design are changed significantly during the engineering design phase. For example:
The initial design of the neutral beam system on the JET tokamak had one single large ion source, whereas the final design has eight smaller beam sources [4] with the accompanying four residual ion deflection and collection systems and four beamline calorimeters.
The initial design of the ITER injectors used a vacuum vessel of cylindrical cross section, and all component removal and maintenance were to be carried out through the rear of that vessel [5]. The design being constructed uses a vessel that is rectangular in cross section with a removable lid that allows removal and maintenance of the beamline components from above the injector [6].
It is clear from the above examples that the resolution of problems arising from operation in the fusion reactor environment, for example, maintenance of the injector components, can depend strongly on details of the injector design and that the methods to achieve the required parameters of the injectors may also depend strongly on the details of the design. Therefore the following sections of this chapter do not consider any design in detail, but, against the background of the design of the injectors for ITER, they try to describe the problems that will arise and to suggest ways in which they might be resolved. Also it is important to understand that the components of a neutral beam injector are interdependent and that in the following sections the assumptions made about the design and/or performance of the injector are self-consistent.
The global efficiency of a heating system is simply the ratio of the electrical power required to operate the heating system divided by the power absorbed by the device being heated, the fusing plasma in the case of a fusion reactor, and it is of overriding importance for a fusion reactor. This can easily be understood with an example: suppose that the heating power required to heat the fusing plasma to the temperature required to ensure that the rate of fusion reactions in the plasma is that required to achieve the electrical output from the reactor is 100 MW. Then, if the global efficiency of the heating system were similar to that achieved by the systems operating today, of the order of 25%, about 400 MW of electrical power would be required simply to operate the heating system, that is, the output of a typical power station. There have been several studies aimed at defining an acceptable global efficiency for the heating systems of a fusion reactor, and the typical result is ≈60% or higher [7].
The specification of the neutral beam injectors designed for ITER is the closest of any design to that which would be suitable for use on a fusion reactor. Thus it is interesting to look at the expected efficiency of the ITER injectors to see where improvements must be made. Table 1 shows the expected performance of an ITER-like injector plus indications of possible performance changes that could lead to an injector operating on a fusion reactor. Each of the suggested changes is discussed in more detail below.
ITER-like injector (MW) | Reactor injector (MW) | ||
---|---|---|---|
1 | RF power to ion source | 0.8 | 0.4 |
2 | Electrical power for the ion source: the AC to RF conversion efficiency for the ITER-like ion source power supplies is ≈50%. The efficiency of the solid-state RF power supplies used for thereactor injectors is assumed to be 85% | 1.6 | 0.5 |
3 | Stripping loss: this is approximately proportional to the gas flow from the source, which is assumed to be reduced by a factor 3 for the reactor injectors | 8.0 | 1.5 |
4 | Back-streaming ion power: this is approximately proportional to the gas flow from the source (see above) | 1.0 | 0.2 |
5 | Electron power exiting the accelerator: this is approximately proportional to the gas flow from the source (see above). | 1.0 | 0.2 |
6 | Total accelerated power | 40.0 | 22.3 |
7 | Total power lost in the accelerator (including back-streaming ions): this is approximately proportional to the gas flow out of the source (see above). | 10.0 | 1.9 |
8 | DC power to accelerator: | 50.0 | 24.1 |
9 | Electrical power to the accelerator: the AC to DC conversion for the accelerator power supplies is assumed to be 87.5% for both injectors | 57.1 | 27.6 |
10 | Beamlet halo: for the beam source of the HNBs, this is assumed to carry 15% of the power of each beamlet, whereas that of the reactor beam source is assumed to be 5% | 6.0 | 1.1 |
11 | Neutral power exiting the neutraliser: neutralisation for the D2 target is ≈56%; with a photon neutraliser, it is assumed to be 90% | 19.0 | 19.0 |
12 | Neutral power to ITER without re-ionisation loss: the geometric transmission is taken to be the same for both injectors, 95%, for the core of the beamlets | 18.1 | 18.1 |
13 | Re-ionisation loss: in the reactor injector, the total gas influx is reduced by a factor of ≈15; consequently the re-ionisation losses are similarly reduced | 0.9 | 0.06 |
14 | Power injected into ITER: | 17.2 | 18.1 |
15 | Electrical power to the electrostatic residual ion dump: this is reduced because of the considerably higher neutralisation achieved with the photon neutraliser | 1.05 | 0.04 |
16 | Electrical power to the laser: 800 kW of laser power is assumed to be required to inject sufficient photons into the neutraliser, and the laser efficiency is assumed to be 40% | 0.0 | 2.0 |
17 | Electrical power to the active correction and compensation coils: assuming that the AC to DC conversion efficiency for the ACC coil power supply is 95% | 1.6 | 1.1 |
18 | Electrical power for the cryogen supply: 0.5 MW is estimated as the additional power at 4 K in the ITER cryoplant needed for the HNB cryopumps (≈5 MW electrical power). The required pumping speed is reduced in proportion to the gas flow per injector, and the power in the reactor cryoplant is similarly reduced. | 5.0 | 0.2 |
19 | Electrical power for the water cooling of the beam source and the beamline components: the power needed for the water pumpsfor the higher efficiency injector is reduced proportionately | 0.8 | 0.1 |
Total electrical power to the injector | 67.2 | 32 | |
Overall efficiency | 26% | 57% |
Global efficiency of the ITER HNBs and possible injectors for a fusion reactor, based on reduced gas flow into the ion source, improved RF power supplies and a photon neutraliser.
Before discussing the various items impacting the global efficiency, it is important to understand some of the more important constraints on the design of the injectors.
Firstly, the injectors will need to be commissioned after the first installation on the reactor and then maintained and recommissioned several times during their lifetime. Commissioning or recommissioning of all the injectors involves firing the neutral beam through the beamline components and into a beam dump, usually called a calorimeter. The overall process is that at the start of commissioning, the beam source is operated at low power and beam energy and for short pulse lengths, for example, 5–10 s. That ensures safe operation of the system even if the beam quality, such as the beamlet divergence, is not optimal. Once safe, good operation is achieved at the selected low power, the beam power, energy, and pulse length are gradually increased. This continues until full power and pulse length are achieved, always with the neutral beam being intercepted on the calorimeter. No system has yet been developed which allows commissioning of the high power beam system without a calorimeter. As it is almost certain that a calorimeter is required, it must be designed to withstand the power and power density it will be subjected to, and this has been demonstrated to be a restricting factor in the design of an injector for the ITER heating NB injectors. The calorimeter was one of the most difficult beamline components to be designed, and it can be reasonably considered that the power and power density handling of the ITER calorimeter design is close to the limit of what is technologically possible. Thus the beamline calorimeter sets a limit on the neutral beam power that can be produced by a neutral beam injector of ≈17 MW. In Table 1, the changes to be made for an injector to be used in a fusion reactor are such that this limitation is respected.
Table 1 gives a calculation of the global efficiency of an ITER-like heating neutral beam injector (HNB) and of a possible injector for a fusion reactor. Both deliver ≈17 MW of 1 MeV D0 to the plasma in the device. The calculations in Table 1 assume that for the injector on a fusion reactor:
The ion source and accelerator will be similar to those of the ITER-like injector.
The gas flow into the ion source will be 3 times lower than the flow into that of the ITER-like injector.
The ion source on the injector on a fusion reactor will be based on solid-state technology with an efficiency of 85%.
A photon neutraliser will be used that has a neutralisation efficiency of 90% and a laser power of 800 kW, with a laser efficiency of 40%. A lower laser efficiency would be acceptable if the required laser power is <800 kW.
This section discusses the items of Table 1 that are considered not to be self-explanatory.
The requirement to limit the neutral power to the calorimeter combined with efficiency increases elsewhere in the injector for a fusion reactor leads to a reduction in the accelerated negative ion current of about a factor 2 (see Section 2.1.1.5.), which leads to a similar reduction in the maximum power into the RF source. The reduction in the accelerated negative ion current leads to a more easily realised extracted negative ion current, lower power to the extraction and acceleration grids, lower back-streaming ion power, and lower electron power exiting the accelerator, all of which are very desirable.
The current design of the RF power supply for the ITER neutral beam injectors uses a high power tetrode oscillator, which results in an efficiency of RF power production of about 50%. More modern RF power supplies which use solid-state technology have a power efficiency of about 85%. The use of such solid-state RF power supplies with an ITER-relevant type of RF-driven ion source has recently been successfully demonstrated at the ELISE facility in IPP, Garching, Germany [8].
The negative ions extracted from the ion source can, and do, undergo diverse charge changing reactions with the background gas:
where the underlined species are high-energy particles. Because the above reactions occur inside the accelerator, the produced
In addition to the above reactions, the accelerated
The
The background gas in the extractor and accelerator of a negative ion-based injector comes overwhelmingly from the ion source, and the background gas density decreases with the distance from the plasma grid. That, combined with the fact that the cross sections of reactions (1)–(13) decrease with the energy of the precursor
In the case of the ITER heating neutral beam injectors, the stripping loss is calculated to be ≈8 MW, and the power in the back-streaming positive ions (mainly from reactions (11)–(13)) is calculated to be ≈1 MW. It is obvious that losing ≈9 MW in an injector that is designed to deliver ≈17 MW to the plasma has a major impact on the global efficiency of the injector, and it must be reduced if the target of 60% global efficiency is to be met. As noted above, most of the background gas in the accelerator comes from the ion source. Hence to achieve a global efficiency of 60%, that gas flow must be reduced. Fortunately, it has been demonstrated with a filamented ion source that extracted current densities higher than those needed in the injectors for a fusion reactor assumed in Table 1 can be achieved with a filling pressure (the pressure in the in source without source operation) of 0.1 Pa [9], a factor 3 lower than the target value for the ITER injectors. Thus that value is chosen in Table 1 for the injector of a fusion reactor. It must be noted that any filamented source, including the source type where operation at the low gas flow has been demonstrated, is not considered suitable for use on an injector to be used on a fusion reactor because of the limited lifetime of the filaments (<200 h). Operation at such a low gas flow has not yet been achieved in the type of source to be used on the ITER injectors, an RF-driven source, and significant R&D is needed to develop an RF-driven source that can operate at such low gas flows.
Back-streaming ions are positive ions that are created inside the accelerator, which are then accelerated back to the ion source by the electrical fields in the accelerator. There are three reasons the power in the back-streaming ions must be reduced in an injector on a reactor:
Reduction of the back-streaming ion power contributes to increasing the global efficiency of the injectors.
Lifetime of the ion source backplates: the back-streaming ions sputter material from the backplates, and eventually the back-streaming ions will drill through the backplate and, most likely, reach the cooling water channel in the backplate. This problem is avoided in the sources designed for ITER by having a 1-mm-thick molybdenum layer on surface of the backplates receiving the back-streaming ions. Most of the sputtering is due to H2+ (from reaction (11)), and the sputtering rate of Mo bombarded by H2+ is low compared to other possible materials (copper, nickel, etc.), and it is calculated that a 1-mm-thick layer of Mo will not be eroded away during the foreseen lifetime of ITER [10]. The calculations in [10] predict an erosion depth of ≈0.5 mm during the ITER lifetime, but they assume that D+ and D2+ are the only back-streaming ions. In fact Cs will be present in the extractor, and at a lower density in the accelerator, that Cs will be ionised by the accelerated D− and back-accelerated into the source. It is calculated that the erosion by Cs+ could be as important as that of the D2+ [11] and that back-streaming Cs+ will overlap with the back-streaming D2+ and add to the erosion by D2+. The erosion over the lifetime of the reactor would be about 20 times higher than in the ITER HNBs, which have a duty cycle of 25%. The Mo layer thickness cannot be increased 20-fold to counter that as that would lead to a design of the backplates that cannot withstand the power density from the back-streaming ions.
Reduction of the Cs “consumption”: the conversion of D atoms impacting the PG with a low work function surface is the main method of D− in the ion source. To create the low work function surface Cs is injected into the ion source and deposited on the PG. If Cs injection is stopped, the extracted ion current is found to decrease after some period of operation, which is due to the an increasing PG surface work function, which may be caused by impurities reacting with the Cs on the PG, or coating of the Cs by other material. This is termed “Cs consumption”. In order to maintain the D− production rate and the extracted D− current constant, it is found necessary to inject Cs into the ion source periodically or even continuously. To avoid the metal sputtered from the backplates that is deposited on the PG, increasing the work function is likely to increase the Cs consumption rate, which is highly undesirable (see Section 4).
It has been suggested that if the plasma grid were made from a low work function material, there would be no need to inject caesium into the source, with the accompanying problems discussed in Section 4. However, as mentioned above, if the PG is coated by several monolayers of metal sputtered from the backplates, the work function will increase leading to a reduction in the negative ion production and hence in the extracted current. The sputtering rate for the ITER beam source is by back-streaming D2+ which is calculated to be 5 × 1016 atoms/s, and the rate for the injector on a reactor may be a factor ≈6 lower if the extracted current density is lower (see Section 1.2) by a factor 2 and the gas density in the accelerator is reduced by a factor 3. As a monolayer corresponds to about 1017 m−2, so it is obvious that several monolayers of the sputtered material will be deposited on the PG in a time that is short compared to the reactor lifetime.
Potential solutions to the problems discussed above are:
Easily replaceable backplates plus a reduction in the back-streaming ion flux. Since the back-streaming D2+ is directly proportional to the of D2 in the extractor and accelerator and that of Cs+ ion intensity is directly proportional to the density of Cs in the extractor, reducing by a factor 3 the D2 flow out of the ion source and the Cs density in front of the PG would reduce the sputtering of the ion source backplates enough to avoid the erosion causing a water leak in <1 year of reactor operation, allowing the backplates to be replaced during an annual maintenance period.
It should be noted that a factor 3 reduction in the sputtering of the backplates is not sufficient to prevent a non-renewable PG surface deteriorating in a time that is short compared to the lifetime of a reactor.
Bending of the D− after the extraction grid and offsetting the subsequent acceleration grids such that the back-streaming ions, which cause most of the sputtering of the backplates, could be directed onto dumps that are separated from the beam source. The reduction in the sputtering thus achieved should be sufficient to allow the backplates to survive for more than 1 year, but replacement of the backplates must be foreseen.
Unfortunately the reduction in the sputtering would not be sufficient to allow a non-renewable low work function PG to maintain its low work function for the lifetime of a reactor. Therefore, the use of a non-renewable low work function PG is not viable.
In situ cleaning of the sputtered material off the PG might allow a low work function PG to be used. Of course that would not solve the backplate problem. As a and b above do not solve the problem of the sputtered material “polluting” the PG, it can be concluded that there is little point in carrying out R&D on the creation of a low work function PG unless a technique is developed to remove the sputtered material from the PG in situ.
Some electrons are co-extracted from the ion source, and, as noted in Section 2.1.1.3, electrons are created in the accelerator via reactions (1)–(13). Electrons in the extractor and accelerator will be co-accelerated along with the negative ions until they are deflected onto the extraction grid or one of the accelerator grids, or they exit the accelerator. The power loss in the extractor is given in Table 1, line 2, and line 5 gives the power in the electrons exiting the accelerator. That power is deposited on downstream beamline components and the beamline vessel. The reduction in the gas density in the extractor and accelerator, as discussed above, results in a reduction in the exiting electron power by a factor similar to the reduction factor for the back-streaming ions.
Line 6 of Table 1 gives the total accelerated D− power for the injector to be used on a fusion reactor as 22.3 MW compared to 40 MW for a heating neutral beam injector for ITER. The main reason for the reduced accelerated D− power is to keep the power density on the calorimeter similar to that of the ITER injector.
Early measurements of negative ion beamlet profiles suggested that the optics of the beamlets are not well described by a simple Gaussian divergence, that is,
where P(ω) is the power density at a radial position that subtends an angle with respect to the beamlet axis of ω and ω0 is the beamlet divergence. The measured profiles were found to be better fitted by a bi-Gaussian profile. For the ITER design, the latter was chosen, that is,
where f is the fraction of the beamlet power carried by the “halo”, which has a divergence of ω0h. For the ITER design, f was assumed to be 15%. It is assumed that R&D from the ITER neutral beam test bed and other negative ion-based systems will allow an improved optics with a halo carrying only 5% of the beamlet power.
All neutral beam injection systems that have been designed or built have been conceived for a pulsed mode operation, whereas fusion reactors, and any NBI system to be used on the reactor, are expected to operate continuously for 1 year or more. Continuous operation will require fundamental changes in the design of the injectors, such as:
All NBI systems so far designed and/or built require very high pumping speed at the exit of the accelerator and downstream of the residual ion dump in order to minimise beam loss. The former is needed in order to reduce the gas density, and hence the stripping losses, in the accelerator and the latter to reduce the pressure in, and downstream of, the residual ion dump and hence the re-ionisation of the neutral fraction of the beam in that region and in the duct leading to the reactor vessel. That is important as re-ionised particles will be deflected into the walls of the duct by the stray magnetic field from the reactor, reducing the injected power as well as heating the duct walls. The latter is important as removing heat deposited in the duct leads to water-cooled components in the duct, and those may occasionally require maintenance. As those components will become highly active during operation of the reactor, such maintenance will only be possible by remote means, which is inherently complicated and difficult. Reducing the power load means that the components can be designed with a high safety factor, leading to less, perhaps no, maintenance in the lifetime of a reactor.
Cryopumps that “wallpaper” each side of the injector beamline vessel can provide a sufficient pumping speed for D2, which in the ITER heating injectors is ≈3 × 106 l/s [12]. Gas is not removed from an injector by cryopumps, it is simply frozen on the cryogenically cooled panels of the pumps, and the quantity of D2 that can be stored on the pumps is limited because of the possible explosion; if the D2 is released from the pumps, there is sufficient oxygen inside the injector, and a source of ignition is present. Although the risk is low, it is not acceptable, especially in the case of a reactor where the injector is part of the confinement barrier. Consequently, when the gas storage limit is reached, it is necessary to regenerate the pumps, i.e. to release the stored D2, and pump it away with an external pumping system. As several injectors are likely to be installed on a reactor in order to provide the required total heating and current drive power, continuous provision of the required power can be assured by installing one “excess” injector. Then if the n injectors are installed, n − 1 injectors provide the required power, and only n − 1 are usually operating. That allows the non-operating injector to be isolated vacuum wise from the reactor and to be regenerated, with each injector being regenerated in turn. That only works if the regeneration time1 is ≤τ/(n − 1) hours, where τ is the time for which each injector can operate before regeneration is needed. As an example, assume that the injectors can be regenerated in 1.5 h and that each injector can operate for >3 h before needing to be regenerated. Then with three injectors installed on the reactor, one is regenerated each hour, so that the cryopump of each injector is regenerated after 3 h of operation; all three injectors are regenerated after 4.5 h, and the cycle is then repeated, as shown in Figure 1. Having an “extra” injector is expensive, both because of the cost of the injector and the additional cost of operating the extra injector and because it reduces the efficiency of the reactor as the wall space needed for the extra injector cannot be used for generating power.2
Schematic of the regeneration cycle for a neutral beam system with three injectors installed, with each injector capable of operating for >3 h before regeneration of the cryopumps being necessary. The yellow areas indicate that the injector is operational and the green ones that it is being regenerated. Two injectors are always operational.
In the example given above, the injectors would have to operate >3 times longer than permitted for the ITER injectors, so that, all other things being unchanged, the total gas flow into the injectors on the reactor would have to be reduced by a factor 3 compared to the gas flow into the ITER injectors, and that must be achieved without degrading the injector performance or the global injection efficiency.
An alternative to having an extra injector is to instal a higher pumping speed than is required for the efficient operation of the injector and to be able to regenerate the “unnecessary” part of the cryopumps in situ. For example, if the installed pumping speed were twice that required for the efficient operation of the injector, then half the pump could be shut off from the injector, whilst the other half continues to operate; once the first half has been regenerated, that can be opened up to the injector and the second half closed off for regeneration and so on. Unfortunately no system for closing off part of a cryopump sufficiently to allow it to be regenerated whilst the rest of the pump continues operation has yet been developed.
In the above discussion, it is assumed that cryopumps will be used in the NB injectors. It has been suggested that non-evaporable getters (NEGs) could be used instead of cryopumps. NEGs have an advantage that no sudden release of the gas captured by the getters is possible; thus there is no safety hazard associated with the storage of large quantities of D2 in the getters. If NEGs are to be considered, a viable assembly of NEGs needs to be designed, using NEGs that will not be poisoned by any impurities in the NB injector and, obviously, that the assembly needs to provide the required pumping speed. However the problem of regeneration of the pumps remains as NEGs do not actually pump the D2 out if the injector, but they trap it within the getter material, and regeneration is needed once the NEGs become saturated with D2. The possible ways to overcome the lack of pumping during regeneration are, in essence, the same as suggested for cryopumps above. However the regeneration time for NEGs is expected to be several hours, so that with three injectors installed on the reactor, as in the above example with cryopumps, the NEGS would have to operate for 10 h if the regeneration time is 5 h. No design of such a system has yet been done.
Because of the quasi-continuous operation of the injectors, all the gas used for the injectors will be gas recovered from the gas recycled through the reactor “tritium plant”. That must include the gas released from the injector cryopumps as that will be contaminated with T2 that has flowed to the injectors from the reactor. However, the gas flowing into the ion sources must contain only a small fraction of T2 to make sure that the neutral beams will have a negligible fraction of T0 as the lower velocity of T0 would lead to deposition in the plasma of the reactor nearer the outside of the plasma which is undesirable.3 The requirement to have fairly pure D2 for the ion source operation impacts directly on the design of the tritium plant, which could lead to substantial cost increase for the tritium plant, and therefore any reduction in that gas flow is highly desirable.
It is to be noted that some of the He produced in the fusion reactions will flow into the neutral beam duct and the injector, adding to the gas density in the duct. That will increase the fraction of the neutral beam that is re-ionised by collisions with the gas in the duct and thus the power to the duct walls. The density of He in the duct and the injector must be kept at a level that the He in the ion source does not compromise its performance and that the He density in the beamline and the neutral beam duct does not significantly enhance re-ionisation losses. An estimate of the density in the ion source and the increase in re-ionisation loss due to the presence of He in the injector and duct is given below:
Assume that a 1 MeV D beam is being injected into the reactor.
If the pumping speed for He in the injectors is zero, the He density in the duct between the injector and the reactor will rise until the flow out of the duct into the reactor is equal to the flow from the reactor into the duct. Assuming that the He temperature in the duct is 100°C (due to collisions with a 100°C duct wall), that the gas flow out of the reactor into the injector duct is ≈1020 atoms/s (a value calculated for the plasma in ITER), and that 10% of the outflow is He (the rest being D and T), the density of He in the duct will be ≈2.5 × 1016 m−3.
Now the He flow out of the injector into the duct must be equal to the flow into the injector from the duct. Assuming that the He temperature in the injector is 20°C (due to collisions with water-cooled components in the injector), then the gas density in the injector will be ≈2.8 × 1016 m−3.
Re-ionisation loss occurs between the entrance to the residual ion dump and the entrance into the reactor. The cross section for re-ionisation of D on He is ≈3 × 10−21 m2. Assume that the length of the duct between the injector and the reactor is 10 m and that the length of the residual ion dump plus that of the beamline calorimeter is 3.5 m. Then the extra re-ionisation loss due to the presence of He in the system is calculated to be ≈0.1%.
If the He temperature in the ion source is 1200 K (the gas temperature in a negative ion source of the type to be used in the ITER injectors has been measured to be 1200 K), then as the He flow into the ion source from the beamline must equal the He flow out of the source, the He density in the ion source will be ≈1.6 × 1016 m−3. To put that in perspective, the D2 density in the ion source should be of the order of 6 × 1018 m−3, that is, the He will represent <0.25% of the gas particles in the ion source.
In conclusion, the small increase in the re-ionisation loss due to the presence of He in the injector and the duct of ≈0.1% is almost certainly acceptable. The presence of an He density of significantly above ≈1.6 × 1016 m−3 has been shown experimentally not to have any significant effect on the source performance [13].
It is currently estimated that Cs will need to be injected into each ion source at a rate of ≈20 mg/h in order to reach the required extracted negative ion current. With quasi-continuous operation and that Cs injection rate, >1 kg will have been injected into each source every 6 years. It has been found that most of the injected Cs remains in the ion source and significantly less than 1 kg of Cs is almost certain to cause operational problems. There are three possible ways to overcome this problem:
Develop a technique for cleaning Cs from an ion source by remote means, so that cleaning of the source can be done during a reactor maintenance period;
Reduce the required Cs injection rate by about a factor 20 so that Cs accumulation in the source does not become a problem during the reactor lifetime;
Develop an alternative to Cs (see is section 2.1.1.3 above).
The injectors will be operating in a very hostile nuclear environment, and that will have an impact on many aspects of the NBI system, for example, the activation and transmutation of materials, the requirement to maintain confinement barriers under operational response and accidental scenarios, etc., and the necessity to meet all nuclear safety requirements. A particularly important aspect of operating in a nuclear environment is that all the components in the actual injectors and the injector vessel and the nuclear shielding around the injectors will become activated during operation; that no human intervention for maintenance operations will be possible, so all maintenance must be carried out remotely; and that requirement must be considered at all stages of the design of the injection system.
The lifetime of fusion reactors must be very long, and similar to that of a fission reactor, for example, >40 years, and, like fission reactors, they will operate continuously between outages for maintenance, which will occur not more frequently than yearly, and the outage time has to be as short as possible, for example, <1 month, see, for example [14]. The time that the NBI system on a reactor must operate, both in total and between maintenance periods, is orders of magnitude beyond any NBI system designed so far, and that means that many new considerations enter into play, such as the lifetime of components which are subjected to sputtering by the beams and thermal fatigue. It is also evident that as the reactor and the injectors will operate for 1 year or more between maintenance periods, any component that is designed to be replaced routinely must be able to operate for more than 1 year before the replacement becomes necessary.
The injector components should be designed to have a fatigue life that is greater than the life of the fusion reactor, that is, about 40 years with essentially continuous operation. When there is a breakdown in the accelerator, the beam will be re-established in ≈180 ms, which is short compared to the thermal response time of the components, and the components “see” only a small part of a thermal cycle. Therefore fatigue failure will arise from the on-off cycles of the beam, when the components will experience the complete thermal cycle. The number of on-off cycles will probably be dominated by the regeneration cycle of the cryopumps. With a photon neutraliser and a gas flow into the ion source that is reduced by a factor 3, the cryopumps should be regenerated after ≈3 h of operation (see Figure 2). As, with continuous operation of the reactor, ≈3000 regenerations will be needed per year, there will be ≈1.2 × 105 cycles in the reactor lifetime, 40 years. The injector will almost certainly require conditioning pulses after a regeneration in order to regain full performance. The low power operation used at the start of the reconditioning does not contribute significantly to fatigue, and about five full power pulses should suffice to complete the conditioning. Thus the injector components will “see” ≈6 × 105 full thermal cycles in the reactor lifetime.
Computer-generated cut-away view of an ITER HNB beamline. The scale below the beamline shows the distance along the beamline axis in metres from the last grid of the accelerator.
The relatively low extracted current assumed above, together with the reduction in the stripping losses by a factor 3 (due to the reduced source gas outflow), means that the power load to the grids should be easily handled and fatigue should not be a problem. Similarly, the power to the residual ion dump will be quite low because of the high neutralisation expected with a photon neutraliser and designing the residual ion dump to have the required fatigue life not be a problem. The reduced gas flow into the injector will significantly reduce the re-ionisation loss, hence the loads to the panels in the duct leading to the reactor, and fatigue should not be a problem. However, even in the reduced current density design considered in Section 1.2, the beamline calorimeter, which is essential for the commissioning and recommissioning of the beam source, will receive a similar power density to that received by the calorimeter of the heating neutral beams of ITER, and the fatigue life of the optimised design of that component is calculated to be ≈7.5 × 104 cycles, so either a non-negligible improvement of the design is needed or the calorimeter will have to be replaced after about 20 years, i.e. once in the lifetime of the reactor.
It is worth emphasising that, as assumed above, it is reasonable to conclude that the power “seen” by the beamline calorimeter of an injector on a reactor cannot be higher than that “seen” by the calorimeter of the heating injectors of ITER, which precludes increasing the accelerated D− current density to >100 A/m2 when a high efficiency neutraliser is used. Another consequence is that any increase in the beam energy would necessitate a decrease in the accelerated current density in order to keep the power to the calorimeter at the acceptable level.
High-power, high-energy neutral beam injectors are large; for example, the ITER 1 MeV heating injectors are ≈15 m long and ≈4 × 4 m in cross section, and the high voltage bushing through which connects the power, gas, and water cooling to the beam is over 6 m tall and 2.5 m in diameter (see Figure 2).
Obviously the injectors will require a large “neutral beam cell” somewhere around the reactor, which must also provide space around the injectors for nuclear and magnetic shielding, and, because the injectors on a reactor will become radioactive, space for the remote handling equipment needed for all maintenance on the injectors. Space around the reactor will also be required for many other types of equipment, and the space for the injectors will inevitably be limited, which will directly influence the design and layout of the injectors and any attachments to the injectors. Some appreciation of the likely space constraints can be gained from the ITER system. The layout of the three heating and one diagnostic neutral beam injectors is shown in Figure 3.
Computer view of the ITER NB cell with three heating neutral beam injectors and a diagnostic neutral beam injector installed. The three heating neutral beam injectors should be capable of injecting 50 MW into the ITER plasma.
The three ITER heating neutral injectors will be capable of injecting “only” 50 MW of D0 into ITER, and significantly higher power may be required on a reactor. If that is realised by adding more injectors, an even larger neutral beam cell will be required. However that might be avoided by increasing the power from each injector, which might be achieved by having a more uniform power density on the calorimeter. In principle, that might be possible as the geometric limitations associated with the gas neutraliser used in the ITER injector would not apply to a photon neutraliser-based system. However that requires detailed considerations of the injector design, and those are not possible with the present state of development of the photon neutraliser.
The injectors at ITER are expected to perform in a harsh nuclear environment which will not be better on a reactor. In the present scheme of things, the injectors are an extension of the vacuum vessel and therefore a part of the nuclear confinement barrier. It is therefore essential that their integrity is assured for all situations including normal and accidental events which can be initiated when the machine operates.
The design and operation of injectors in a nuclear environment need to be considered from various aspects such as the engineering design codes used, the injector materials, their layout, their operational response to normal and accidental scenarios under various load conditions, and maintenance, including remote handling, tooling, and the deployment of remote handling tools. All those have been addressed for the ITER injectors, and the impact on the design has been very significant. Some of the various aspects are discussed below in order to give an idea of the complexity involved in adapting the systems to nuclear environments.
Operation in a radiation environment impacts the choice of materials used for components, such as to ensure that the essential material characteristics are not modified by irradiation and to reduce the degree of activation and the quantity of activated waste. This impacts on all parts of the injector, including, for example, the choice of vacuum seals, where, essentially, only all metal seals are accepted, the joining techniques for similar and dissimilar materials, etc. The definitions for reactors will be stringent because of the harsh environment and strict safety standards that will be applied. Radiation can damage electronics, components, and sensors, corrupt signals, and make optical fibres and windows become opaque. These effects can appear instantaneously or over a period of time due to an accumulation of, for example, atomic displacements. It is clear that the design of an injector designed to operate on a reactor will have to ensure that all electronics are situated in low radiation areas, as has been done for the ITER design, both to ensure their lifetime is adequate and to allow their maintenance.
Designing a system for the environment of a reactor requires a serious consideration of the layout of the injectors, ensuring good access for the remote handling tooling and adequate shielding in case of the need for man access. Meeting these requirements requires sufficient space, but there is a conflicting requirement, which is to keep the “nuclear island” as small as possible. The latter means that the location of the inventory, the first confinement boundary, is confined to as small an area as possible. The vacuum boundary of the machine, in normal operation, defines the first confinement barrier, and any penetration through the barrier becomes part of the first confinement barrier. To ensure reliability and safety, it is likely that two metal valves will need to be installed, in series, upstream of any penetration of the barrier, as is the case on ITER. In that case, the vacuum boundary of the machine and the second valve, which is the last layer of the primary confinement barrier, defines the nuclear island. To minimise the size of the nuclear island, the valves and windows must be located as close as possible to the machine. This can lead to a complex design which must tolerate high radiation loads, heat loads, neutron fluxes, and electromagnetic loads whilst simultaneously fulfilling the safety function of primary confinement. An example of the impact on the injector design is that this means that any guide tubes for the laser light used for the photon neutraliser will need to incorporate a window in series with a valve close to the injector vessel. That window will have to meet all the requirement of the first confinement barrier and vacuum boundary as well as be able to transmit the laser light quasi-continuously. As some laser power will be absorbed by the window, it is probable that the window will need to be cooled by some type of cooling system. Also the window must be capable of withstanding any over pressure or heat load that might occur during the failure inside the reactor.
To ensure safe operation of injectors on a reactor, all possible accidental events will have to be analysed under all possible load conditions including those arising from abnormal plasma events such as a “vertical displacement event” (VDE),4 and under all conditions, i.e. when the system is operating, in stand-by or being maintained. In addition, nuclear analyses will have to be performed to confirm that radiation damage to the materials will be below the level at which the mechanical properties are compromised.
Operation in a nuclear environment limits direct access and hands on maintenance as the injector will become radioactive, and there are then hazards related to exposure to radiation and from inhalation of airborne contamination. The expected level of radioactivity in the ITER NB cell and the defined radiation zoning of the facility lead to the need for remote handling to be in place. Human access is only allowed when the dose rates are kept beneath the allowed limits of <100 μSv/h. Achieving the compliance with the radiation zoning is carried out by the use of effective shielding in the design of the components and reducing materials which are more activated, i.e. using low cobalt content stainless steel, but achieving a similar situation on a reactor will be difficult.
A global efficiency of ≈60% or better is required for a neutral beam system on a reactor, which is much higher than any neutral beam system has achieved so far. Meeting that requirement represents a major challenge for neutral beam development. To do so requires both a significant increase in the neutralisation efficiency and a decrease in the losses in the system.
Increasing the neutralisation efficiency appears most feasible, if difficult, with a photon neutraliser. The only identified alternative is a plasma neutraliser plus energy recovery. However, work so far carried out on this topic has failed, by a wide margin, to produce an adequate D+ and D2+ + electron plasma target5 nor to demonstrate how to produce a plasma confinement system that allows the transmission of the beam through the neutraliser that does not degrade the beam emittance. Additionally recovering the energy from the D+ fraction of the beam leaving the neutraliser has severe difficulties and has not been demonstrated [15, 16, 17].
The stripping losses in the extractor and accelerator of the beam sources of the ITER heating injectors are very high (≈30%) and must be reduced. That can only be achieved by reducing the gas flow out of the source into the extractor and accelerator, which would also reduce the back-streaming in power into the ion source and the sputtering from the ion source backplates.
Solid-state RF power supplies have an efficiency of ≈85% and must be used for injectors on a reactor that use RF-driven ion sources.
Sputtering from the ion source backplates by the back-streaming ions means that the PG surface will be coated in the sputtered material in a time that is very short compared to the operational time between the reactor maintenance periods. That will result in an increase of the work function and a significant reduction in the extracted ion current. Thus either the PG needs to be replaced or the surface renewed. Replacing the PG is not reasonably possible with the current type of accelerator design. Therefore R&D into low work function PG surfaces should not be prioritised. However the continued use of Cs injection means that:
The Cs flow into the source must be significantly reduced to avoid excessive Cs accumulation in the source, and ways of in situ cleaning the source of Cs needs to be developed (see Section 1.1.2).
Preliminary estimates indicate that back-streaming Cs+ may cause significant sputtering of the ion source backplates, adding to the erosion by back-streaming D2+. Therefore the Cs density in the extractor must be reduced via a reduction in the Cs in the in source plasma, and R&D on easily exchangeable ion source backplates may be essential.
Meeting the pumping requirements of the injectors during very long pulse operation is very difficult, even with a substantial reduction of the gas flow into the ion source and no gas into the neutraliser. The only systems that can provide the required pumping speed are cryopumps, and possibly non-evaporable getters (NEGs), and neither of those actually pumps gas out of the injector. Consequently, such pumps require regular regeneration to avoid possible explosions and/or to avoid saturation of the pumps. As no way has yet been developed to allow an injector to continue operation whilst the pumps are regenerated, the only option is to take the injector off-line during the regeneration. That problem could be overcome by having one “excess” injector, so that of the n injectors installed, only n − 1 injectors are ever operating, and each injector is regenerated in turn.
Because the beamline component will become activated during the operation of the reactor, any maintenance or exchange of the components will have to be done remotely, and all such operations will be very difficult. That consideration leads to the requirement that all the components must be designed to have an expected life that is longer than that of the reactor, for example, with a fatigue life of >40 years. The calorimeter of the injectors of a reactor will “see” a similar thermal load to that of the calorimeter of the ITER injectors, even though the accelerated current density is reduced by 50% of that expected with the ITER system. The ITER calorimeter design was extremely challenging, and it is unlikely that the design of the calorimeter of the injectors on a reactor will be significantly better. The calorimeter of the ITER injectors has a calculated fatigue life of 7.5 × 104 thermal cycles, and R&D is needed to meet the full fatigue lifetime requirement which could be ≈5 × 105, i.e. 8 times higher.
The injectors on a reactor will have to fit into the available space, and they will have to minimise their impact on the size of the nuclear island. The resulting space constraints will impact on the design and the layout options of the injectors and any attachments to the injectors, and the requirement that all maintenance must be carried out by remote means, with the consequent need for space around the injectors for the remote handling equipment, must be taken into account during the design of the injectors. An obvious conclusion is that in order to be considered for R&D funding, any proposal for R&D should consider the possible implications of the nuclear environment and propose conceptual solutions to those implications.
The views and opinions expressed herein do not necessarily reflect those of the ITER organisation.
Stress-induced cardiomyopathy is caused by intense emotional or physical stress leading to rapid and severe reversible cardiac dysfunction. This condition can occur following a variety of emotional stressors such as grief, fear, extreme anger, and surprise. On the other hand, many physical stressors (i.e., stroke, seizure or acute asthma) can also trigger the condition. Suspicion of stress cardiomyopathy is based on clinical symptoms, abnormal electrocardiogram (ECG), mildly elevated serum cardiac troponin, significantly elevated serum natriuretic peptide levels (BNP or NT-proBNP), and noninvasive cardiovascular imaging. Stress-induced cardiomyopathy symptoms following severe stress are often indistinguishable from a heart attack and may include: (1) chest pain, dyspnea, or both during stress period (often sudden and intense) [1]; (2) shortness of breath, (3) rapid or irregular heartbeat, (4) sweating and (5) dizziness [2]. The exact pathophysiology of stress-induced cardiomyopathy remains elusive, and several mechanisms may be involved (Figure 1).
Schematic diagram of the pathological mechanism of stresses-induced cardiac dysfunction. β-AR, estrogen receptor beta; ROS/RNS, reactive oxygen/nitrogen species; MAPK, mitogen-activated protein kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; SERCA2, sarcoplasmic reticulum calcium ATPase 2; RyR, ryanodine receptor; Nrf2, nuclear factor erythroid-derived 2-like 2; ATP, adenosine triphosphate; PDE5A, phosphodiesterase 5A; SIRT1, Sirtuin 1; PGC1-alpha, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; OKG, cGMP-dependent protein kinase or protein kinase G.
Considering the causes of stress-induced cardiomyopathy, the exact cause of stress-induced cardiomyopathy is unclear. In patients without coronary heart disease, emotional stress can lead to severe, reversible left ventricular dysfunction. Although the mechanism of stress-induced cardiomyopathy is unclear, excessive sympathetic stimulation may be central to its etiology, perhaps involving excess catecholamines (Figure 1), but the link between the two is unclear. One possibility is ischemia due to epicardial coronary spasm; additionally increased sympathetic tone can lead to vasoconstriction in patients without coronary artery disease [3]. Other studies have demonstrated that these patients have reduced coronary flow reserve and regional deficits in cardiac imaging [4]. Another possible mechanism for catecholamine-mediated myocardial stunning is direct muscle cell damage, as the density of adrenergic receptors in the apex is higher than in other areas of the myocardium [1]. Elevated levels of catecholamines lead to a concentration-dependent decrease in muscle cell viability, which can be explained by the marked release of creatine kinase in cells and the decreased viability due to calcium overload mediated by circulating AMPs [5]. Animal models suggest that catecholamines are a potential source of free radicals, which in turn may contribute to cardiomyopathy by promoting lipid peroxidation, increasing membrane permeability and muscle cell damage (Figure 1) [6]. Myocyte dysfunction may be caused by increased trans-sarcolemmal calcium influx and cellular calcium overload as free radicals interfere with the transport capacity of sodium and calcium transporters (Figure 1) [7]. Abnormal coronary blood flow has recently been reported in patients with stress-related myocardial dysfunction in the absence of obstructive disease [8]. Evidence that stress cardiomyopathy may be caused by neurogenic myocardial stunning also revealed a unique pattern of ventricular synergy with meta-iodobenzyl guanidine myocardial scintigraphy, suggesting the presence of cardiac sympathetic hyperactivity and maintaining coronary blood flow [9]. The distribution of primary cardiac injury did not correspond to the perfusion area of a single coronary artery. Plasma levels of catecholamines and stress-related neuropeptides are usually higher than the patient’s physiological levels. Unlike polymorphonuclear inflammation in stress cardiomyopathy infarcts, contractile band necrosis is a distinct form of stress-induced cardiomyocyte injury characterized by hypercontraction of sarcomeres, eosinophilic transverse bands, and interstitial mononucleitis, and endomyocardial biopsy shows contractile band necrosis in patients with this syndrome [1]. Research shows that contractile band necrosis is a type of cell death detected as early as 2 min after cell injury, resulting in the release of cardiac enzymes [10]. Excessive circulating catecholamines and focal myocarditis contractile bands were found in the circulatory system of pheochromocytoma, suggesting a circulating catecholamine dependence of focal myocarditis [11], subarachnoid hemorrhage [12, 13], eclampsia [13], and in persons who died from fatal asthma necrosis [14]. All together, these suggest that catecholamines may be the link between emotional stress and heart damage (Figure 1).
A surge of stress hormones may temporarily damage the heart, many studies have found. Triggers of stress cardiomyopathy due to stress hormones include: (1) financial stress; (2) surgical stress; (3) bereavement stress; (4) asthma attack stress; (5) chronic disease or diagnostic stress; (6) other. Risk factors for stress cardiomyopathy are also quite different from any physical discomfort, mainly including: (1) age: most cases occur in people over 50; (2) intense physical or emotional events: such as a loved one accidental death, medical diagnosis, sudden economic decline or unemployment, divorce, physical abuse, car accident, major surgery, natural disaster, or intense fear; (3) side effects of certain medications: some are used to treat severe allergic reactions, diabetic neurological problems, depression symptoms or hypothyroidism drugs, etc. may cause a surge in stress hormones, leading to stress cardiomyopathy; (4) gender: this condition affects women much more than men; (5) neurological disorders; (6) previous or current mental illness.
Stress-induced cardiomyopathy is diagnosed by looking for certain markers to distinguish it from other heart conditions. Possible tests should include: (1) blood tests: to check the levels of certain fats, cholesterol, sugars, and proteins in the blood; (2) chest X-ray: common imaging tests of the lungs, heart, and aorta; (3) coronary angiography: this the procedure is usually done in conjunction with cardiac catheterization; (4) echocardiography: this test uses sound waves to take dynamic pictures of the heart’s chambers and valves; (5) electrocardiogram (ECG): this test measures the electrical activity of the heart and can help determine whether a part of the heart is enlarged, overworked, or damaged; (6) Magnetic Resonance Imaging (MRI): uses large magnets, radio waves, and a computer to produce images of the heart and blood vessels.
Over the past decade, research on psychosocial risk factors for heart disease has made great strides [15]. According to epidemiological studies [16], behavioral risk factors for heart disease can be divided into five categories [17]: (1) physical health behaviors; (2) negative emotional and mental states; (3) chronic stress; (4) social isolation and lack of social support; and (5) lack of a sense of purpose.
New research suggests that poor sleep quality and inappropriate rest and relaxation are also behavior-related risk factors for heart disease [18]. As far as sleep is concerned, recent meta-analyses have shown that both insomnia and long or short sleep duration are risk factors for heart disease [19]. Excessive sleep duration can be a potential marker of depression or medical comorbidities, while too short sleep duration can be caused by multiple factors, including sleep deprivation or sleep deprivation due to worrying and other causes of insomnia. As the workload becomes heavier and the pace of life becomes faster, the boundaries between work and leisure are disappearing, and the value of relaxation has become more important. Theoretically, relaxation may benefit physiological and cognitive functions, but so far, epidemiological studies in this area are relatively lacking.
Studies have consistently shown that depression is an important risk factor for heart disease [20], and a series of meta-analyses have demonstrated a significant effect of depression on prognosis, including a meta-analysis of 54 studies showing that depression nearly doubled the risk of heart disease in a community cohort population [21].
In recent years, studies have identified anxiety as one of the risk factors for heart disease [22]. Many meta-analyses of community cohorts and patient cohorts have shown that anxiety symptoms increase the risk of heart disease [23]. Other studies have shown that patients with generalized anxiety disorder, panic attacks, and post-traumatic stress syndrome have an increased risk of heart disease events [24].
Mental outlook is also one of the determinants of health, with optimists being more positive, having enhanced social functioning and better recovery from myocardial infarction or heart surgery [25]. Recent epidemiological data suggest that pessimism increases the risk of cardiac events, stroke, and/or all-cause mortality [26].
So far, most studies on chronic stress have focused on situational stress [29], and work stress [30] is the most widely studied one. A recent meta-analysis showed that occupational stress was associated with increase in heart disease events [31]. Separation and divorce are two other common stressors that increase the risk of death [32], and independent epidemiological studies have also shown an association between marital stress and cardiovascular events [33].
It is worth mentioning that personal stress perception may also be one of the important factors affecting health [34]. A study that assessed levels of stress perception and perceptions of whether stress was harmful to health in 28,753 participants showed that stress increased mortality only in those who self-assessed risk harmful to health [35]. A complementary study showed that guiding individuals to understand stress as a positive effect improved cognitive and cardiovascular responses to stress. Combining the above two studies, we should further study the individual’s perception of stress and the impact of its regulation on health.
Epidemiological studies consistently show that small social networks, lack of social support, loneliness, and/or feelings of lack of emotional support increase the risk of cardiac events [36]. Like other psychosocial risk factors, the likelihood of adverse cardiac events increases with the degree of lack of social support, and a positive social overall can nearly triple survival [37].
Observational studies have shown that a strong sense of purpose in life is central to leading an active life, and that a lack of purpose in life can lead to boredom, increase risk of depression, and diminish resilience. Although only a few studies have assessed the pathophysiological outcomes of lack of purpose, a large number of recent studies have shown that lack of purpose increases the risk of death [38].
Negative psychosocial factors contribute to the development of disease by forming negative behaviors and direct pathophysiological effects. These effects vary by type of psychosocial stress, but as a whole include autonomic dysfunction, cardiovascular hyperresponsiveness, insulin resistance, central obesity, increased risk of hypertension, endothelial and platelet dysfunction, and brain adverse changes in adaptive and cognitive function, etc. [39].
Conversely, positive psychosocial factors favor healthy behaviors and promote beneficial physiological effects, including enhanced immune and endothelial and autonomic function. In addition, positive psychosocial functioning contributes to increased vitality, which in turn increases presence, purpose, and resistance [40].
With the transition from the biomedical model to the biopsychosocial medical model, the psychosomatic relationship of cardiovascular disease has attracted more attention. Most cardiovascular diseases have both biomedical and psychosocial factors in the pathogenesis; in terms of clinical symptoms, there are both somatic and psychological symptoms. Growing research is finding a strong link between mood and morbidity and mortality of CVD, as one of the common public health problems worldwide [41], arousing social concern [42]. With the transition from the traditional biomedical model to the modern biopsychosocial medical model, the psychosomatic relationship of CVD has attracted more attention. The effect of emotion on cardiovascular health can be explained by certain association mechanisms, but the specific and clear association mechanism has not yet formed a consensus.
Emotion is a short-lived, strong attitude and experience that an individual is stimulated by the living environment, accompanied by obvious physiological changes and external manifestations of a psychological state [43]. Psychologists divide emotions into two dimensions: negative emotions and positive emotions. Negative emotion is a negative emotion triggered by anticipation of future events and memory of past time, which can manifest in different forms (such as panic, anxiety, depression, hostility, etc.) [44].
Previous studies have found that patients with acute myocardial infarction are often in varying degrees of negative emotional states after experiencing a sense of near-death [44, 45]. Some studies have also shown that patients with heart failure have poor quality of life, and the incidence of anxiety and depression are 62% and 65%, respectively [46]. On the one hand, negative emotions are one of the independent predictors of poor prognosis in hospitalized patients with CVD [47]. Conversely, positive emotions are associated with a reduced risk of CVD [45, 47]. However, the internal mechanism of the two is still unclear.
The study found that the biological mechanism of the influence of emotion on cardiomyopathy is mainly reflected in the two aspects of vascular endothelial injury and inflammatory response, as well as the activity of the autonomic nervous system (Figure 1) [48].
The early manifestation of cardiomyopathy is the damage of the vascular endothelium [49]. Studies have found that there is a correlation between emotional state and the state of the cardiovascular endothelium [50]. Massachusetts area in the United States found that positive mood (joy) was inversely correlated with inducible nitric oxide synthase promoter methylation [51], which play an important role in maintaining the homeostasis of vascular function.
The autonomic nervous system has an important regulatory mechanism for the cardiovascular system, including the sympathetic nervous system and the parasympathetic nervous system (Figure 1) [52]. Heart rate variability (HRV) is a commonly used index for evaluating autonomic nerve function and the risk of sudden cardiac death. HRV analysis can effectively evaluate the state of cardiac autonomic nerve function. It is a relatively independent index for predicting the short- and long-term prognosis of various CVDs and sudden cardiac death [53]. Liu [54] found that when healthy individuals were exposed to negative emotional stress, the production of cardiac autonomic nerve function was significantly different. Similar changes in the pathological state of coronary heart disease suggest that long-term negative emotions may be one of the reasons for individual parasympathetic nerve damage.
There is increasing evidence that, in addition to traditional factors, mental stress plays an important role in the occurrence and development of cardiovascular disease [55]. The psychological stress generated in daily life and work can lead to the occurrence of myocardial ischemia, which is clinically referred to as mental stress-induced cardiomyopathy (MSIC) [56]. In addition to affecting the quality of life of patients, mental stress-induced myocardial ischemia (MSIMI) can also lead to a worsening clinical prognosis and an increased risk of death. Its pathogenesis and pathogenesis are different from those of exercise stress or drug-related myocardial ischemia. The incidence of MSIMI is 20–70%, and it will double the adverse cardiac events [57]. Therefore, in-depth understanding of the pathogenesis of MSIMI and timely diagnosis and treatment, is of great clinical significance.
Understanding the clinical features of MSIC will help clinicians identify MSIC patients early and treat them in a timely manner.
Depression and anxiety are risk factors for cardiomyopathy, aggravate the process of heart disease, and affect the prognosis of heart disease. Patients with heart disease complicated by depression or anxiety have a higher incidence of MSIC after mental stress [58].
During mental stress, changes in brain function are related to the occurrence of MSIC. Studies have shown that compared with patients with heart disease without depression, patients with heart disease and severe depression have increased activity in the parietal cortex after mental stress stimulation [59]. Another study showed that mental stress-induced vasoconstriction is associated with modulation of brain function, with stress increasing activation in the insula and parietal cortex but decreasing activation in the medial prefrontal cortex [60].
Changes in cardiac markers may be associated with MSIC. Highly sensitivity cardiac troponin I (hs-cTnI) is an indicator of myocardial infarction or myocardial injury and is associated with myocardial ischemia caused by mental stress. Studies have shown that compared with heart disease patients without MSIC, patients with heart disease combined with MSIMI have higher serum hs-cTnI levels, and increased N-terminal pro-B-type natriuretic peptide and mean systolic blood pressure after mental stress [55]. Numerous studies have shown that myocardial hypoxia can lead to the elevation of B-type natriuretic peptide (BNP). Elevated BNP levels may be a marker of myocardial ischemia in a meta-analysis of 2784 patients eligible for standard noninvasive stress testing [61].
After psychological stress, coronary heart disease patients with severe left ventricular dysfunction have a higher risk of MSIC than patients with normal left ventricular function [62]. The product of heart rate and systolic blood pressure and peripheral arterial tension were measured in resting state and 30 min after mental stress, respectively. It was found that higher hemodynamics and vasoconstriction response were high risk factors for MSIC [63].
When people cope with mental stress, the paraventricular nucleus of the hypothalamus will secrete corticotropin-releasing hormone, which will cause the anterior pituitary to secrete corticotropin, which will stimulate the adrenal cortex to produce cortisol. Decreased baroreceptor reflex sensitivity can lead to myocardial ischemia and even severe arrhythmia and sudden death. Broadley et al. [64] found that the application of metyrapone, a drug that blocks cortisol release, prevented mental stress-related endothelial dysfunction and reduced baroreflex sensitivity. In addition, Seldenrijk et al. [65] showed that, in healthy elderly populations, an enhanced cortisol response to stressful stress was associated with an increased risk of coronary artery calcification.
During mental stress, the excitability of the cardiac sympathetic nervous system increases, and the activated sympathetic nervous system promotes the release of catecholamines (including epinephrine, norepinephrine, and dopamine), resulting in increased blood pressure, increased heart rate, increased myocardial contractility, and cardiac output (Figure 1) [63]. The study of Wittstein et al. [1] showed that under strong mental stress in patients with stress cardiomyopathy, the level of catecholamines increased rapidly, and the excitability of the sympathetic nervous system was significantly enhanced, which led to the disturbance of neurohumoral regulation, resulting in increased myocardial vitality, myocardial damage, myocardial reversibility and left ventricular dysfunction (Figure 1).
Inflammation is closely related to mental stress and cardiovascular disease. When the body responds to mental stress, blood vessels constrict and blood flow increases, prompting white blood cells and platelets to release inflammatory mediators [56]. When the stress is weak, the body can play a defensive role through the inflammatory response. When the stress is strong, excessive inflammatory mediators lead to vascular endothelial damage, which further promotes inflammatory response and inflammatory mediators, as well as promotes inflammatory cells to infiltrate myocardial tissue, leading to myocardial ischemia necrosis and cardiovascular disease [56]. Hammadah et al. [56] showed that the levels of inflammatory factors such as interleukin-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9, increased in patients with heart disease after mental stress. The level of matrix metalloproteinase-9 was negatively correlated with cortisol after stress. In conclusion, the relationship between inflammation-related factors and MSIC remains to be further explored (Figure 1).
Genetic factors are one of the important reasons for the onset of cardiovascular diseases. Mental and psychological diseases are also closely related to an individual’s response to stressful stimuli. For example, the serotonin transporter gene (SLC6A4) polymorphism is associated with emotion regulation in humans, and S allele carriers cause more severe fear and anxiety under mental stress [50]. Studies on the Val66Met single nucleotide polymorphism of brain-derived neurotrophic factor (BDNF) have shown that BDNFMet/Val carriers have a higher incidence of cognitive and mental disorders and coronary heart disease [51, 66].
Chagas disease is named after Carlos Ribeiro Justiniano Chagas, a Brazilian doctor and researcher who discovered the disease in 1909. In May 2019, according to the decision of the Seventy-second World Health Assembly, World Day against Chagas Disease was set on April 14 (the day in 1909, when Carlos Chagas diagnosed the first human case of the disease in a two-year-old girl named Berenice). Chagas disease, also known as American trypanosomiasis, is a life-threatening disease caused by the protozoan parasite
Chagas disease was once completely confined to rural areas of the American continent—mostly Latin America (excluding the Caribbean islands). Most of the infected people live in urban environments (urbanization), mainly due to increased population mobility over the past few decades, with an increasing number of infections found in the United States, Canada, many European countries, and some African, Eastern Mediterranean, and Western Pacific countries [72].
In Latin America,
Chagas disease is divided into four phases: incubation phase, acute phase, interminate phase and chronic phase.
The incubation period for
The initial acute phase lasts about 2 months after infection. During the acute phase, a large number of parasites circulate in the blood. However, most cases are asymptomatic or mild and nonspecific. In less than 50% of people bitten by triatomine bugs, the typical first sign seen can be a skin lesion or bruising and swelling on one eyelid. In addition, fever, headache, swollen lymph nodes, pallor, muscle pain, difficulty breathing, swelling, and abdominal or chest pain may also present. In the acute phase, fever (missing or intermittent), rash, hepatosplenomegaly, lymphadenopathy, and non-inflammatory edema may be present and may be limited to the face or systemic. Trypanosoma’s enter tissues during or after parasemia, causing myocarditis and endocarditis, sinus tachycardia, mitral systolic murmur, cardiac hypertrophy, and meningoencephalitis. Symptoms disappear after more than 4 to 12 weeks. Severe cases are more common in neonates, young children, the elderly and immunosuppressed. Heart failure or ventricular fibrillation and meningoencephalitis caused by early myocarditis during this period can often lead to death. When more advanced electrocardiographic findings are present, including right bundle-branch block (RBBB), atrial fibrillation, or ventricular arrhythmias, they signal a worse prognosis [74].
The interminate phase is almost asymptomatic, but progresses to a chronic, symptomatic phase, including the gradual development of irreversible life-threatening and disabling comorbidities, especially to those who are immunosuppressed. Physical examination is normal, and resting electrocardiogram is normal. Only special inspection method can find abnormalities. This is the beginning of the chronic phase. This type can persist for 20 to 30 years, or even life.
During the chronic phase, the parasite hides mainly in the muscles of the heart and digestive tract. Ten to thirty years later, up to 30% of patients develop cardiac disorders and up to 10% develop gastrointestinal (typically enlarged esophagus or colon), neurological, or mixed lesions. In later years, infections in these patients can lead to myocardial and neurological damage, followed by arrhythmias or progressive heart failure and sudden death. The disease usually begins years or decades after the onset of parasitemia. (1) Cardiomyopathy in endemic areas: trypanosomiasis cardiomyopathy is the main cause of heart disease and sudden death. Patients often develop congestive heart failure with an enlarged heart. Two-thirds of patients have cardiac conduction disorders, often right bundle branch block, polygenic premature contractions, and myocardial necrosis. The disease course can be short and sudden death, or death from long-term heart failure. In addition, emboli from the apex or atrium can cause sudden death due to cerebral or pulmonary embolism. (2) Dilation of multiple organs: in Brazil, Chile, and some parts of Argentina, there are multiple organ expansions, mainly the esophagus and colon. Difficulty swallowing is often caused by esophageal expansion, constipation caused by colon expansion, and volvulus may also occur, such as acute abdomen. As for the giant stomach, giant duodenum, giant bronchus, giant ureter, etc. have been reported but rare.
Pathological changes in the acute phase showed mononuclear cell infiltration [81], interstitial edema [82], accumulation of amastigotes in muscle cells of subcutaneous tissue [83], and formation of pseudocysts at the invasion site of Trypanosoma [83]. Myocarditis with cardiac enlargement is usually seen in acute-phase deaths. In patients with sudden death in the chronic phase (mostly due to ventricular arrhythmia or conduction block), the heart size is usually normal or only slightly enlarged. In other patients with chronic Chagas heart disease, cardiac hypertrophy, dilation, and thickening can be seen, especially in the apex of the heart, resulting in apical aneurysm. Mural thrombosis and lung and peripheral organ embolism may be seen in some patients. Microscopic examination showed mononuclear cell infiltration, myocardial fiber hypertrophy, degeneration, necrosis and edema. Microscopic changes in megaesophagus or megacolon are similar to those of the heart.
We firstly have shown that cardiac mitochondria-response plays a very important roles in
The tobacco-induced cardiomyopathy accounts for 9.4 million, or 16.6%, of the 56 million deaths worldwide each year [99]. Smoking causes 1.62 million (18%) deaths from heart disease worldwide [100], and cause severe ill health, with an estimated 40.6 million daily lost to heart disease [100].
Tobacco use (smoked and smokeless) and exposure to secondhand tobacco causes heart disease through a variety of mechanisms, including inflammation, blood vessels shrinkage, clot formation, and reduced oxygen supply (Figure 1) [101, 102, 103]. Smoking-mediated thrombosis appears to be a major factor in the pathogenesis of acute cardiovascular disease [101]. Nicotine stimulates the heart, which increases the demand for oxygen to the heart muscle, triggering angina. Smokers are more likely to develop acute cardiovascular disease at a young age and early in their illness [101]. The associated effects of exposure to secondhand smoke on the heart are almost as severe as the effects of smoking itself, and likely through the same biological mechanisms [104]. Exposure to secondhand smoke in as little as 1 h can increase the risk of heart attack [105].
Risk of damage to the cardiovascular system increases with duration of smoking and the amount and type of smoking tobacco products consumed. However, the close relationship between dose and response is not linear [101]. Even with low exposure levels, the risk increases substantially—people who smoke only one cigarette a day have half the risk of coronary heart disease as those who smoke at least 20 cigarettes a day [106]. In addition to being a major independent risk factor for coronary heart disease, smoking may act synergistically with other major risk factors for coronary heart disease, such as high cholesterol, untreated hypertension, and diabetes [107, 108]. In 2017, an estimated 382 000 deaths from coronary heart disease were attributable to exposure to secondhand smoke [106], accounting for 4.3% of total deaths from coronary heart disease and 31% of total deaths from exposure to secondhand smoke [106]. In the same year, exposure to secondhand smoke was also estimated to be responsible for an estimated 8.8 million disability-adjusted life-years (DALYs) lost to coronary heart disease [106]. Various systematic reviews and meta-analyses have shown that adults exposed to secondhand smoke have a 23–30% increased risk of coronary heart disease in countries with high to low-income levels [101, 109, 110, 111, 112]. Cohort studies conducted in multiple countries in the 1970s and 1980s showed that children’s exposure to secondhand smoke has adverse effects on cardiovascular disease, including premature atherosclerosis [113, 114]. A major challenge in these studies is accurately assessing lifetime exposure to secondhand smoke. The cumulative total lifetime exposure to secondhand smoke may be much higher than reflected during the study period [104], which may lead to an underestimation of the true risk of exposure to secondhand smoke and the impact on heart disease [104]. A recent study led by the tobacco industry claims that electronic nicotine delivery systems (ENDS) are less harmful than cigarettes [115, 116]. However, ENDS may be more toxic than inhaled ones at low in conventional cigarettes and tobacco products, but they are not harmless, and there are risks associated with use and secondhand exposure [41, 117]. ENDS linked to increased risk of cardiovascular disease Association [118, 119]. The toxic substances contained in these products can lead to causes impaired endothelial function, arterial stenosis, increased heart rate and increased blood pressure [120, 121, 122]. Concomitant use with smoking (this is most ENDS common practice of users), effects of a combination of two or more products [123]. Tobacco control measures have been shown to benefit heart health place. For example, raising tobacco taxes is directly related to reducing tobacco consumption. Associated with improved heart health [124].
Due to the many pathogenic and negative effects on the heart from smoking on the heart, the market for smoking and nicotine replacement has grown rapidly in recent years. Since 2006, e-cigarettes have become more popular due to their perceived safety profile compared to traditional cigarette smoking. An electronic cigarette (or e-cigarette) is a battery-operated device for heating solutions (or e-liquids) containing nicotine, propanediol alcohol and vegetable glycerin [120, 125, 126]. E-cigarettes not only attract smokers who are trying to quit smoking, but are also becoming more popular among non-smokers, who have even become the main force in the e-cigarette market. Since the advent of electronic cigarettes, its design has constantly changed, but there has been little regulatory control. Common forms of e-cigarettes are the first generation of disposable “Cigalikes”, the second generation of rechargeable devices, and the third generation of water tanks, pens and personalized large cigarettes, boxes, and pod-based devices.
The team of Nicholas D Buchanan of The Ohio State University School of Medicine published a paper in the journal Cardiovascular Research, reviewing clinical studies related to the cardiovascular risk of e-cigarettes. This review discusses recent relevant studies from the existing literature, focusing on components and potential cardiovascular risks associated with e-cigarette vapor exposure and on evaluating and broadly discussing data from preclinical and epidemiological studies on the cardiovascular effects of acute (short-term) and chronic (long-term) exposure to e-cigarettes [127]. e-cigarettes increased hyperlipidemia [128], sympathetic dominance [129], endothelial dysfunction [130], DNA damage [131], macrophage activation [132, 133]. Multiple studies suggest e-cigarettes may increase CVD risk.
Severe burns can lead to severe hemodynamic and cardiodynamic disturbances, which can lead to sepsis, multiple organ failure, and death. Cardiac stress is a hallmark of acute-phase response to burns, and poorer burn recovery outcomes are associated with severe cardiac insufficiency [134, 135, 136]. Severe burn injury has a profound and widespread effect on an individual’s cardiovascular system. Early features include myocardial contractile dysfunction and increased vascular permeability.
Plasma levels of catecholamines, vasopressin, angiotensin-II [137] and neuropeptide-Y [138] are significantly elevated after severe burns, which may be responsible for the deleterious effects on cardiovascular function. Nearly 7% of children with 70% burn area develop dilated cardiomyopathy (DCM) [139, 140]. Burn-induced cardiomyopathy usually develops several weeks to several months after injury [139, 141]. The initial cardiac response to severe burns is characterized by reduced cardiac output and metabolic rate (Figure 1). Other hemodynamic features of burn shock include stroke volume, venous return, coronary blood flow, peak systolic blood pressure, mean arterial pressure, estimated myocardial work, stroke work, myocardial oxygen consumption, myocardial oxygenation, myocardial contractility, decreased force and myocardial compliance [142]. This initial response will result in left-right heart failure and decreased cardiac contractility and is thought to be mediated by circulating vasoconstrictors (Figure 1).
Physiologically, burn-induced myocardial dysfunction is characterized by decreased isovolumic relaxation, impaired contractility, and decreased left ventricular diastolic compliance [143, 144] resulting in decreased cardiac output and metabolic rate [138, 145], leading to myocardial oxygen demand, leading ultimately to right and left heart deficits (Figure 1) [143, 146]. Following burn injury, the volume of circulating plasma is markedly reduced due to increased capillary permeability [147] and a concomitant decrease in cardiac output. Depending on the extent of the burn injury, this defect may directly lead to a severe hypermetabolic response [148] and is positively correlated with the size of the original injury [148]. Poor functional recovery from severe burns is associated with high mortality, high infection rates, and cardiac insufficiency [136, 149, 150].
Cardiac stress-induced increases in plasma catecholamines mediate postburn hypermetabolic responses [136, 151, 152]. Upregulation of catecholamines and other catabolic agents such as glucagon and cortisol may induce hyperdynamic cardiovascular responses [134]. Elevated catecholamines and other catabolic agents are further exacerbated by the substantial loss of plasma volume following burns. Hypovolemic shock, typified by severe burns and major tissue trauma, results in marked tachycardia, increased myocardial oxygen demand, and decreased contractility (Figure 1) [134]. This eventually leads to increased mortality during acute hospitalization [153]. Severe burns suffer from a profound hypermetabolic response mediated by a surge in plasma catecholamines. Sustained release of large circulating catecholamines may be detrimental to the myocardium, increasing myocardial oxygen delivery and leading to focal degeneration and hypertrophy of the myocardium [134]. Elevated plasma catecholamine levels persist for months to years resulting in cardiac stress and cardiac physiologic disturbance for at least 2 years [154]. This in turn leads to cardiac insufficiency, regional myocardial hypoxia, and cardiac death [155]. Therefore, clinical concern about catecholamine levels is related to burn-induced cardiomyopathy, myocarditis, pathological myocardial injury and necrosis [156, 157].
We applied mature animal burn models including rat and mouse, established by UTMB Health’s Blocker Burn Center, to identify the heart tissue-specific up−/down-regulated genes/proteins/metabolisms via transcriptomics/proteomics/metabolomics, and have many hypothesizes based on the differences. Briefly, the SIRT1-PGC1α-NFE2L2-ARE pathway [158], and PDE5A-cGMP-PKG pathway [159] were involved in the burn-induced cardiomyopathy. To confirm our above observations, we treated burn injury animals with PDE5A inhibitor [159, 160] (Sildenafil), and APMK inhibitor (Domorsorphin)/APMK activator (A769662)/PGC1α activator (ZLN005) [158] to partially/completely recoveries of burn-induced cardiomyopathy. Another important contribution for burn-induced cardiomyopathy was that burn injury disrupts the heart mitochondria (mt) with evidence of cardiomyocyte mtDNA damage [159, 161], mt electron transport chain (ETC) dysfunction, mt membrane potential damage, disrupted mt integrity and significant increase of mt ROS production [159, 161]. Treatment with mitochondrial-target drug (Mito-TEMPO) can be beneficial for burn injury–induced cardiomyopathy (Figure 1) [161].
We would like to acknowledge David J. Chavarria, who assisted in the correction of the manuscript.
The authors declare no conflict of interest.
B-type natriuretic peptide cardiovascular disease brain-derived neurotrophic factor electrocardiogram electronic nicotine delivery systems heart rate variability high-density lipoprotein highly sensitive cardiac troponin I low-density lipoprotein mental stress-induced cardiomyopathy mental stress-induced myocardial ischemia mitochondria
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links.
",metaTitle:"List of Institutions by Country",metaDescription:"If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. However, if your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).",metaKeywords:null,canonicalURL:"open-access-funding-institutions-list",contentRaw:'[{"type":"htmlEditorComponent","content":"Book Chapters and Monographs
\\n\\nBook Chapters
\\n\\nMonographs Only
\\n\\n\\n\\nBook Chapters and Monographs
\\n\\nMonographs Only
\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nBook Chapters and Monographs
\\n\\n\\n\\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\\n\\nCSIC affiliated authors can also take advantage of a central Open Access fund (amounting to 10,000 EUR) to cover up to 50% of the rest of the OAPF until it expires. Effective for chapters accepted from January 1, 2020.
\\n\\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\\n\\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\\n\\n\\n\\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\\n\\nBook Chapters and Monographs
\\n\\nBook Chapters and Monographs
\\n\\nBook Chapters and Monographs
\\n\\nBook Chapters and Monographs
\\n\\nThe Claremont Colleges are pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\\n\\nCorresponding authors will receive a 15% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\\n\\nThe University of Massachusetts, Amherst is pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\\n\\nCorresponding authors will receive a 10% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\\n\\nThe University of Surrey is pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\\n\\nCorresponding authors will receive a 10% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\\n\\nMonographs Only
\\n\\n\\n\\nImportant: You must be a member or grantee of the above listed institutions in order to apply for their Open Access publication funds.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Book Chapters and Monographs
\n\n\n\nBook Chapters
\n\nMonographs Only
\n\n\n\nBook Chapters and Monographs
\n\nMonographs Only
\n\nBook Chapters and Monographs
\n\n\n\nBook Chapters and Monographs
\n\n\n\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\n\nCSIC affiliated authors can also take advantage of a central Open Access fund (amounting to 10,000 EUR) to cover up to 50% of the rest of the OAPF until it expires. Effective for chapters accepted from January 1, 2020.
\n\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\n\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\n\n\n\nCorresponding authors will receive a 25% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters. A 20% discount for publishing a long-form monographs, 25% for compacts and 23% for short-form monographs.
\n\nBook Chapters and Monographs
\n\nBook Chapters and Monographs
\n\nBook Chapters and Monographs
\n\n\n\nBook Chapters and Monographs
\n\nThe Claremont Colleges are pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\n\nCorresponding authors will receive a 15% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\n\nThe University of Massachusetts, Amherst is pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\n\nCorresponding authors will receive a 10% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\n\nThe University of Surrey is pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\n\nCorresponding authors will receive a 10% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\n\nMonographs Only
\n\n\n\nImportant: You must be a member or grantee of the above listed institutions in order to apply for their Open Access publication funds.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13404},{group:"region",caption:"Middle and South America",value:2,count:11681},{group:"region",caption:"Africa",value:3,count:4213},{group:"region",caption:"Asia",value:4,count:22423},{group:"region",caption:"Australia and Oceania",value:5,count:2020},{group:"region",caption:"Europe",value:6,count:33699}],offset:12,limit:12,total:135704},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"7"},books:[{type:"book",id:"11774",title:"International Law - A Practical Manual",subtitle:null,isOpenForSubmission:!0,hash:"c607e873911da868c0764770dc224313",slug:null,bookSignature:"Dr. Michael Underdown",coverURL:"https://cdn.intechopen.com/books/images_new/11774.jpg",editedByType:null,editors:[{id:"478218",title:"Dr.",name:"Michael",surname:"Underdown",slug:"michael-underdown",fullName:"Michael Underdown"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11775",title:"Global Peace and Security",subtitle:null,isOpenForSubmission:!0,hash:"131303f07b492463a5c4a7607fe46ba9",slug:null,bookSignature:"Dr. Norman Chivasa",coverURL:"https://cdn.intechopen.com/books/images_new/11775.jpg",editedByType:null,editors:[{id:"331566",title:"Dr.",name:"Norman",surname:"Chivasa",slug:"norman-chivasa",fullName:"Norman Chivasa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11776",title:"Fashion Industry",subtitle:null,isOpenForSubmission:!0,hash:"e8d53d1029a7bccf825aa55d43fecc68",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11776.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12134",title:"Sustainable Tourism",subtitle:null,isOpenForSubmission:!0,hash:"bb510c876f827a1df7960a523a4b5db3",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12134.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12138",title:"Online Advertising",subtitle:null,isOpenForSubmission:!0,hash:"d1a7aaa841aba83e7199b564c4991cf1",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12138.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12139",title:"Global Market and Trade",subtitle:null,isOpenForSubmission:!0,hash:"fa34af07c3a9657fa670404202f8cba5",slug:null,bookSignature:"Dr.Ing. Ireneusz Miciuła",coverURL:"https://cdn.intechopen.com/books/images_new/12139.jpg",editedByType:null,editors:[{id:"243649",title:"Dr.Ing.",name:"Ireneusz",surname:"Miciuła",slug:"ireneusz-miciula",fullName:"Ireneusz Miciuła"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12141",title:"Leadership - Advancing Great Leadership Practices and Good Leaders",subtitle:null,isOpenForSubmission:!0,hash:"85f77453916f1d80d80d88ee4fd2f2d1",slug:null,bookSignature:"Dr. Joseph Crawford",coverURL:"https://cdn.intechopen.com/books/images_new/12141.jpg",editedByType:null,editors:[{id:"420133",title:"Dr.",name:"Joseph",surname:"Crawford",slug:"joseph-crawford",fullName:"Joseph Crawford"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:22},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:6},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:15},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:37},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:15},{group:"topic",caption:"Mathematics",value:15,count:8},{group:"topic",caption:"Medicine",value:16,count:61},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:2},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:5},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:7},popularBooks:{featuredBooks:[{type:"book",id:"10827",title:"Oral Health Care",subtitle:"An Important Issue of the Modern Society",isOpenForSubmission:!1,hash:"9a0ceb9ced4598aea3f3723f6dc4ea04",slug:"oral-health-care-an-important-issue-of-the-modern-society",bookSignature:"Lavinia Cosmina Ardelean and Laura Cristina Rusu",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",editors:[{id:"180569",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10780",title:"Current Trends in Orthodontics",subtitle:null,isOpenForSubmission:!1,hash:"badce0e23eb5176fd653b049d5295c0a",slug:"current-trends-in-orthodontics",bookSignature:"Farid Bourzgui",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",editors:[{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8452",title:"Organizational Conflict",subtitle:"New Insights",isOpenForSubmission:!1,hash:"96bdaaba38a7850a7e7379aa5a505748",slug:"organizational-conflict-new-insights",bookSignature:"Josiane Fahed-Sreih",coverURL:"https://cdn.intechopen.com/books/images_new/8452.jpg",editors:[{id:"103784",title:"Dr.",name:"Josiane",middleName:null,surname:"Fahed-Sreih",slug:"josiane-fahed-sreih",fullName:"Josiane Fahed-Sreih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10206",title:"Terahertz Technology",subtitle:null,isOpenForSubmission:!1,hash:"2cdb79bf6297623f1d6202ef11f099c4",slug:"terahertz-technology",bookSignature:"Borwen You and Ja-Yu Lu",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg",editors:[{id:"191131",title:"Dr.",name:"Borwen",middleName:null,surname:"You",slug:"borwen-you",fullName:"Borwen You"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11331",title:"Secondary Metabolites",subtitle:"Trends and Reviews",isOpenForSubmission:!1,hash:"7d6274f42d5441e537c5fa744bc84523",slug:"secondary-metabolites-trends-and-reviews",bookSignature:"Ramasamy Vijayakumar and Suresh Selvapuram Sudalaimuthu Raja",coverURL:"https://cdn.intechopen.com/books/images_new/11331.jpg",editors:[{id:"176044",title:"Dr.",name:"Ramasamy",middleName:null,surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10793",title:"Molecular Mechanisms in Cancer",subtitle:null,isOpenForSubmission:!1,hash:"3ed2817275edb3de6f5683602314706e",slug:"molecular-mechanisms-in-cancer",bookSignature:"Metin Budak and Rajamanickam Rajkumar",coverURL:"https://cdn.intechopen.com/books/images_new/10793.jpg",editors:[{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10957",title:"Liquid Crystals",subtitle:null,isOpenForSubmission:!1,hash:"7a2d81fa4893fcf74e7b3823a3e4f385",slug:"liquid-crystals",bookSignature:"Pankaj Kumar Choudhury and Abdel-Baset M.A. Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/10957.jpg",editors:[{id:"205744",title:"Dr.",name:"Pankaj",middleName:null,surname:"Kumar Choudhury",slug:"pankaj-kumar-choudhury",fullName:"Pankaj Kumar Choudhury"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10652",title:"Information Extraction and Object Tracking in Digital Video",subtitle:null,isOpenForSubmission:!1,hash:"d13718b2d986d058d55cf91e69bf21c0",slug:"information-extraction-and-object-tracking-in-digital-video",bookSignature:"Antonio José Ribeiro Neves and Francisco Javier Gallegos-Funes",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",editors:[{id:"1177",title:"Prof.",name:"António",middleName:"J. R.",surname:"José Ribeiro Neves",slug:"antonio-jose-ribeiro-neves",fullName:"António José Ribeiro Neves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10820",title:"Data Clustering",subtitle:null,isOpenForSubmission:!1,hash:"086d299ffd05aacd2311c3ca4ebf0d3a",slug:"data-clustering",bookSignature:"Niansheng Tang",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",editors:[{id:"221831",title:"Prof.",name:"Niansheng",middleName:null,surname:"Tang",slug:"niansheng-tang",fullName:"Niansheng Tang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10728",title:"Blood Groups",subtitle:"More than Inheritance of Antigenic Substances",isOpenForSubmission:!1,hash:"b5e79b54a382651f3130c9ee5ab862b4",slug:"blood-groups-more-than-inheritance-of-antigenic-substances",bookSignature:"Kaneez Fatima Shad",coverURL:"https://cdn.intechopen.com/books/images_new/10728.jpg",editors:[{id:"31988",title:"Prof.",name:"Kaneez",middleName:null,surname:"Fatima Shad",slug:"kaneez-fatima-shad",fullName:"Kaneez Fatima Shad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4802},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10827",title:"Oral Health Care",subtitle:"An Important Issue of the Modern Society",isOpenForSubmission:!1,hash:"9a0ceb9ced4598aea3f3723f6dc4ea04",slug:"oral-health-care-an-important-issue-of-the-modern-society",bookSignature:"Lavinia Cosmina Ardelean and Laura Cristina Rusu",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",publishedDate:"August 17th 2022",numberOfDownloads:2310,editors:[{id:"180569",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"August 17th 2022",numberOfDownloads:2095,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10780",title:"Current Trends in Orthodontics",subtitle:null,isOpenForSubmission:!1,hash:"badce0e23eb5176fd653b049d5295c0a",slug:"current-trends-in-orthodontics",bookSignature:"Farid Bourzgui",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",publishedDate:"August 17th 2022",numberOfDownloads:2079,editors:[{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8452",title:"Organizational Conflict",subtitle:"New Insights",isOpenForSubmission:!1,hash:"96bdaaba38a7850a7e7379aa5a505748",slug:"organizational-conflict-new-insights",bookSignature:"Josiane Fahed-Sreih",coverURL:"https://cdn.intechopen.com/books/images_new/8452.jpg",publishedDate:"August 17th 2022",numberOfDownloads:1987,editors:[{id:"103784",title:"Dr.",name:"Josiane",middleName:null,surname:"Fahed-Sreih",slug:"josiane-fahed-sreih",fullName:"Josiane Fahed-Sreih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10206",title:"Terahertz Technology",subtitle:null,isOpenForSubmission:!1,hash:"2cdb79bf6297623f1d6202ef11f099c4",slug:"terahertz-technology",bookSignature:"Borwen You and Ja-Yu Lu",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg",publishedDate:"August 17th 2022",numberOfDownloads:1528,editors:[{id:"191131",title:"Dr.",name:"Borwen",middleName:null,surname:"You",slug:"borwen-you",fullName:"Borwen You"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11331",title:"Secondary Metabolites",subtitle:"Trends and Reviews",isOpenForSubmission:!1,hash:"7d6274f42d5441e537c5fa744bc84523",slug:"secondary-metabolites-trends-and-reviews",bookSignature:"Ramasamy Vijayakumar and Suresh Selvapuram Sudalaimuthu Raja",coverURL:"https://cdn.intechopen.com/books/images_new/11331.jpg",publishedDate:"August 17th 2022",numberOfDownloads:932,editors:[{id:"176044",title:"Dr.",name:"Ramasamy",middleName:null,surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10793",title:"Molecular Mechanisms in Cancer",subtitle:null,isOpenForSubmission:!1,hash:"3ed2817275edb3de6f5683602314706e",slug:"molecular-mechanisms-in-cancer",bookSignature:"Metin Budak and Rajamanickam Rajkumar",coverURL:"https://cdn.intechopen.com/books/images_new/10793.jpg",publishedDate:"August 17th 2022",numberOfDownloads:700,editors:[{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10957",title:"Liquid Crystals",subtitle:null,isOpenForSubmission:!1,hash:"7a2d81fa4893fcf74e7b3823a3e4f385",slug:"liquid-crystals",bookSignature:"Pankaj Kumar Choudhury and Abdel-Baset M.A. Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/10957.jpg",publishedDate:"August 17th 2022",numberOfDownloads:676,editors:[{id:"205744",title:"Dr.",name:"Pankaj",middleName:null,surname:"Kumar Choudhury",slug:"pankaj-kumar-choudhury",fullName:"Pankaj Kumar Choudhury"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7215,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10652",title:"Information Extraction and Object Tracking in Digital Video",subtitle:null,isOpenForSubmission:!1,hash:"d13718b2d986d058d55cf91e69bf21c0",slug:"information-extraction-and-object-tracking-in-digital-video",bookSignature:"Antonio José Ribeiro Neves and Francisco Javier Gallegos-Funes",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",publishedDate:"August 17th 2022",numberOfDownloads:602,editors:[{id:"1177",title:"Prof.",name:"António",middleName:"J. R.",surname:"José Ribeiro Neves",slug:"antonio-jose-ribeiro-neves",fullName:"António José Ribeiro Neves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"8452",title:"Organizational Conflict",subtitle:"New Insights",isOpenForSubmission:!1,hash:"96bdaaba38a7850a7e7379aa5a505748",slug:"organizational-conflict-new-insights",bookSignature:"Josiane Fahed-Sreih",coverURL:"https://cdn.intechopen.com/books/images_new/8452.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"103784",title:"Dr.",name:"Josiane",middleName:null,surname:"Fahed-Sreih",slug:"josiane-fahed-sreih",fullName:"Josiane Fahed-Sreih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10778",title:"Model-Based Control Engineering",subtitle:"Recent Design and Implementations for Varied Applications",isOpenForSubmission:!1,hash:"e39a567d9b6d2a45d0a1d927362c9005",slug:"model-based-control-engineering-recent-design-and-implementations-for-varied-applications",bookSignature:"Umar Zakir Abdul Hamid and Ahmad `Athif Mohd Faudzi",coverURL:"https://cdn.intechopen.com/books/images_new/10778.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"268173",title:"Dr.",name:"Umar Zakir Abdul",middleName:null,surname:"Hamid",slug:"umar-zakir-abdul-hamid",fullName:"Umar Zakir Abdul Hamid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10780",title:"Current Trends in Orthodontics",subtitle:null,isOpenForSubmission:!1,hash:"badce0e23eb5176fd653b049d5295c0a",slug:"current-trends-in-orthodontics",bookSignature:"Farid Bourzgui",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10793",title:"Molecular Mechanisms in Cancer",subtitle:null,isOpenForSubmission:!1,hash:"3ed2817275edb3de6f5683602314706e",slug:"molecular-mechanisms-in-cancer",bookSignature:"Metin Budak and Rajamanickam Rajkumar",coverURL:"https://cdn.intechopen.com/books/images_new/10793.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11308",title:"Selected Topics on Infant Feeding",subtitle:null,isOpenForSubmission:!1,hash:"213c3e403327a2919eca1dc5e82a0ec3",slug:"selected-topics-on-infant-feeding",bookSignature:"Isam Jaber AL-Zwaini and Haider Hadi AL-Musawi",coverURL:"https://cdn.intechopen.com/books/images_new/11308.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"30993",title:"Prof.",name:"Isam Jaber",middleName:null,surname:"Al-Zwaini",slug:"isam-jaber-al-zwaini",fullName:"Isam Jaber Al-Zwaini"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11331",title:"Secondary Metabolites",subtitle:"Trends and Reviews",isOpenForSubmission:!1,hash:"7d6274f42d5441e537c5fa744bc84523",slug:"secondary-metabolites-trends-and-reviews",bookSignature:"Ramasamy Vijayakumar and Suresh Selvapuram Sudalaimuthu Raja",coverURL:"https://cdn.intechopen.com/books/images_new/11331.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"176044",title:"Dr.",name:"Ramasamy",middleName:null,surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10820",title:"Data Clustering",subtitle:null,isOpenForSubmission:!1,hash:"086d299ffd05aacd2311c3ca4ebf0d3a",slug:"data-clustering",bookSignature:"Niansheng Tang",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"221831",title:"Prof.",name:"Niansheng",middleName:null,surname:"Tang",slug:"niansheng-tang",fullName:"Niansheng Tang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10827",title:"Oral Health Care",subtitle:"An Important Issue of the Modern Society",isOpenForSubmission:!1,hash:"9a0ceb9ced4598aea3f3723f6dc4ea04",slug:"oral-health-care-an-important-issue-of-the-modern-society",bookSignature:"Lavinia Cosmina Ardelean and Laura Cristina Rusu",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"180569",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ardelean",slug:"lavinia-ardelean",fullName:"Lavinia Ardelean"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11139",title:"Geochemistry and Mineral Resources",subtitle:null,isOpenForSubmission:!1,hash:"928cebbdce21d9b3f081267b24f12dfb",slug:"geochemistry-and-mineral-resources",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11139.jpg",editedByType:"Edited by",publishedDate:"August 17th 2022",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"633",title:"Physical Cosmology",slug:"cosmology-physical-cosmology",parent:{id:"101",title:"Cosmology",slug:"cosmology"},numberOfBooks:8,numberOfSeries:0,numberOfAuthorsAndEditors:94,numberOfWosCitations:82,numberOfCrossrefCitations:67,numberOfDimensionsCitations:118,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"633",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10954",title:"Dark Matter",subtitle:"Recent Observations and Theoretical Advances",isOpenForSubmission:!1,hash:"b0fbd6ee0096e4c16e9513bf01273ab3",slug:"dark-matter-recent-observations-and-theoretical-advances",bookSignature:"Michael L. Smith",coverURL:"https://cdn.intechopen.com/books/images_new/10954.jpg",editedByType:"Edited by",editors:[{id:"59479",title:"Dr.",name:"Michael",middleName:"L.",surname:"Smith",slug:"michael-smith",fullName:"Michael Smith"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9982",title:"Cosmology 2020",subtitle:"The Current State",isOpenForSubmission:!1,hash:"35188e364272b0f50d145f33b01931fa",slug:"cosmology-2020-the-current-state",bookSignature:"Michael L. Smith",coverURL:"https://cdn.intechopen.com/books/images_new/9982.jpg",editedByType:"Edited by",editors:[{id:"59479",title:"Dr.",name:"Michael",middleName:"L.",surname:"Smith",slug:"michael-smith",fullName:"Michael Smith"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7389",title:"Redefining Standard Model Cosmology",subtitle:null,isOpenForSubmission:!1,hash:"25572d83043224835eabdf8632fc64ed",slug:"redefining-standard-model-cosmology",bookSignature:"Brian Albert Robson",coverURL:"https://cdn.intechopen.com/books/images_new/7389.jpg",editedByType:"Edited by",editors:[{id:"102886",title:"Prof.",name:"Brian Albert",middleName:null,surname:"Robson",slug:"brian-albert-robson",fullName:"Brian Albert Robson"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6693",title:"Essentials on Dark Matter",subtitle:null,isOpenForSubmission:!1,hash:"7b9819be21ab94f8d165da9b5531b6bc",slug:"essentials-on-dark-matter",bookSignature:"Abraão Jessé Capistrano de Souza",coverURL:"https://cdn.intechopen.com/books/images_new/6693.jpg",editedByType:"Edited by",editors:[{id:"52362",title:"Dr.",name:"Abraao",middleName:"Jesse",surname:"Capistrano",slug:"abraao-capistrano",fullName:"Abraao Capistrano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3211",title:"Open Questions in Cosmology",subtitle:null,isOpenForSubmission:!1,hash:"6e4e21582afb611a1552d8493d66f82c",slug:"open-questions-in-cosmology",bookSignature:"Gonzalo J. Olmo",coverURL:"https://cdn.intechopen.com/books/images_new/3211.jpg",editedByType:"Edited by",editors:[{id:"61779",title:"Dr.",name:"Gonzalo J.",middleName:null,surname:"Olmo",slug:"gonzalo-j.-olmo",fullName:"Gonzalo J. Olmo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1680",title:"Space Science",subtitle:null,isOpenForSubmission:!1,hash:"2429d8599f5c44daca7b0d12f3d70bb8",slug:"space-science",bookSignature:"Herman J. Mosquera Cuesta",coverURL:"https://cdn.intechopen.com/books/images_new/1680.jpg",editedByType:"Edited by",editors:[{id:"15074",title:"Dr.",name:"Herman J.",middleName:null,surname:"Mosquera Cuesta",slug:"herman-j.-mosquera-cuesta",fullName:"Herman J. Mosquera Cuesta"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1374",title:"Aspects of Today's Cosmology",subtitle:null,isOpenForSubmission:!1,hash:"6f152698fbe6139a2fe31a70ec8668d0",slug:"aspects-of-today-s-cosmology",bookSignature:"Antonio Alfonso-Faus",coverURL:"https://cdn.intechopen.com/books/images_new/1374.jpg",editedByType:"Edited by",editors:[{id:"62140",title:"Prof.",name:"Antonio",middleName:null,surname:"Alfonso-Faus",slug:"antonio-alfonso-faus",fullName:"Antonio Alfonso-Faus"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"400",title:"Advances in Modern Cosmology",subtitle:null,isOpenForSubmission:!1,hash:"042beba0021ef61f561bf65a1fb2b115",slug:"advances-in-modern-cosmology",bookSignature:"Adnan Ghribi",coverURL:"https://cdn.intechopen.com/books/images_new/400.jpg",editedByType:"Edited by",editors:[{id:"58295",title:"Dr.",name:"Adnan",middleName:null,surname:"Ghribi",slug:"adnan-ghribi",fullName:"Adnan Ghribi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:8,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"41690",doi:"10.5772/52455",title:"Where Is the PdV in the First Law of Black Hole Thermodynamics?",slug:"where-is-the-pdv-term-in-the-first-law-of-black-hole-thermodynamics-",totalDownloads:3450,totalCrossrefCites:16,totalDimensionsCites:30,abstract:null,book:{id:"3211",slug:"open-questions-in-cosmology",title:"Open Questions in Cosmology",fullTitle:"Open Questions in Cosmology"},signatures:"Brian P. Dolan",authors:[{id:"155570",title:"Dr.",name:"Brian",middleName:"P.",surname:"Dolan",slug:"brian-dolan",fullName:"Brian Dolan"}]},{id:"33700",doi:"10.5772/29840",title:"Geomagnetically Induced Currents as Ground Effects of Space Weather",slug:"geomagnetically-induced-currents-as-ground-effects-of-space-weather",totalDownloads:2814,totalCrossrefCites:8,totalDimensionsCites:12,abstract:null,book:{id:"1680",slug:"space-science",title:"Space Science",fullTitle:"Space Science"},signatures:"Risto Pirjola",authors:[{id:"79589",title:"Dr.",name:"Risto",middleName:"Juhani",surname:"Pirjola",slug:"risto-pirjola",fullName:"Risto Pirjola"}]},{id:"41610",doi:"10.5772/52041",title:"Extended Theories of Gravitation and the Curvature of the Universe – Do We Really Need Dark Matter?",slug:"extended-theories-of-gravitation-and-the-curvature-of-the-universe-do-we-really-need-dark-matter-",totalDownloads:1719,totalCrossrefCites:11,totalDimensionsCites:11,abstract:null,book:{id:"3211",slug:"open-questions-in-cosmology",title:"Open Questions in Cosmology",fullTitle:"Open Questions in Cosmology"},signatures:"L. Fatibene and M. Francaviglia",authors:[{id:"154114",title:"Prof.",name:"Mauro",middleName:null,surname:"Francaviglia",slug:"mauro-francaviglia",fullName:"Mauro Francaviglia"},{id:"154550",title:"Dr.",name:"Lorenzo",middleName:null,surname:"Fatibene",slug:"lorenzo-fatibene",fullName:"Lorenzo Fatibene"}]},{id:"41682",doi:"10.5772/51807",title:"Introduction to Palatini Theories of Gravity and Nonsingular Cosmologies",slug:"-introduction-to-palatini-theories-of-gravity-and-nonsingular-cosmologies-",totalDownloads:2797,totalCrossrefCites:2,totalDimensionsCites:9,abstract:null,book:{id:"3211",slug:"open-questions-in-cosmology",title:"Open Questions in Cosmology",fullTitle:"Open Questions in Cosmology"},signatures:"Gonzalo J. Olmo",authors:[{id:"61779",title:"Dr.",name:"Gonzalo J.",middleName:null,surname:"Olmo",slug:"gonzalo-j.-olmo",fullName:"Gonzalo J. Olmo"}]},{id:"18674",doi:"10.5772/23035",title:"Warm Inflationary Universe Models",slug:"warm-inflationary-universe-models",totalDownloads:2515,totalCrossrefCites:0,totalDimensionsCites:7,abstract:null,book:{id:"1374",slug:"aspects-of-today-s-cosmology",title:"Aspects of Today's Cosmology",fullTitle:"Aspects of Today's Cosmology"},signatures:"Sergio del Campo",authors:[{id:"50288",title:"Prof.",name:"Sergio",middleName:null,surname:"Del Campo",slug:"sergio-del-campo",fullName:"Sergio Del Campo"}]}],mostDownloadedChaptersLast30Days:[{id:"66783",title:"Introductory Chapter: Standard Model of Cosmology",slug:"introductory-chapter-standard-model-of-cosmology",totalDownloads:1480,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"7389",slug:"redefining-standard-model-cosmology",title:"Redefining Standard Model Cosmology",fullTitle:"Redefining Standard Model Cosmology"},signatures:"Brian Albert Robson",authors:[{id:"102886",title:"Prof.",name:"Brian Albert",middleName:null,surname:"Robson",slug:"brian-albert-robson",fullName:"Brian Albert Robson"}]},{id:"41230",title:"Cosmological Constant and Dark Energy: Historical Insights",slug:"cosmological-constant-and-dark-energy-historial-insights",totalDownloads:3135,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"3211",slug:"open-questions-in-cosmology",title:"Open Questions in Cosmology",fullTitle:"Open Questions in Cosmology"},signatures:"Emilio Elizalde",authors:[{id:"154905",title:"Prof.",name:"Emilio",middleName:null,surname:"Elizalde",slug:"emilio-elizalde",fullName:"Emilio Elizalde"}]},{id:"18676",title:"Introduction to Modified Gravity: From the Cosmic Speedup Problem to Quantum Gravity Phenomenology",slug:"introduction-to-modified-gravity-from-the-cosmic-speedup-problem-to-quantum-gravity-phenomenology",totalDownloads:2182,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1374",slug:"aspects-of-today-s-cosmology",title:"Aspects of Today's Cosmology",fullTitle:"Aspects of Today's Cosmology"},signatures:"Gonzalo J. Olmo",authors:[{id:"61779",title:"Dr.",name:"Gonzalo J.",middleName:null,surname:"Olmo",slug:"gonzalo-j.-olmo",fullName:"Gonzalo J. Olmo"}]},{id:"41688",title:"Leptogenesis and Neutrino Masses in an Inflationary SUSY Pati-Salam Model",slug:"leptogenesis-and-neutrino-masses-in-an-inflationary-susy-pati-salam-model",totalDownloads:2052,totalCrossrefCites:2,totalDimensionsCites:5,abstract:null,book:{id:"3211",slug:"open-questions-in-cosmology",title:"Open Questions in Cosmology",fullTitle:"Open Questions in Cosmology"},signatures:"C. Pallis and N. Toumbas",authors:[{id:"154011",title:"Dr.",name:"Constantinos",middleName:null,surname:"Pallis",slug:"constantinos-pallis",fullName:"Constantinos Pallis"},{id:"164280",title:"Dr.",name:"Nikolaos",middleName:null,surname:"Toumbas",slug:"nikolaos-toumbas",fullName:"Nikolaos Toumbas"}]},{id:"41282",title:"Plasma Vortices in Planetary Wakes",slug:"plasma-vortices-in-planetary-wakes",totalDownloads:1731,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"3211",slug:"open-questions-in-cosmology",title:"Open Questions in Cosmology",fullTitle:"Open Questions in Cosmology"},signatures:"H. Pérez-de-Tejada, Rickard Lundin and D. S. Intriligator",authors:[{id:"79235",title:"Dr.",name:"Hector",middleName:null,surname:"Perez-De-Tejada",slug:"hector-perez-de-tejada",fullName:"Hector Perez-De-Tejada"}]}],onlineFirstChaptersFilter:{topicId:"633",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:126,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:13,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Rosa María Martínez-Espinosa is a Full Professor of Biochemistry and Molecular Biology at the University of Alicante, Spain, and has been the vice president of International Relations and Development Cooperation at this university since 2010. She created the research group in applied biochemistry in 2017 (https://web.ua.es/en/appbiochem/), and from 1999 to the present has made more than 200 contributions to Spanish and international conferences. Furthermore, she has around seventy-five scientific publications in indexed journals, eighty book chapters, and one patent to her credit. Her research work focuses on microbial metabolism (particularly on extremophile microorganisms), purification and characterization of enzymes with potential industrial and biotechnological applications, protocol optimization for genetically manipulating microorganisms, gene regulation characterization, carotenoid (pigment) production, and design and development of contaminated water and soil bioremediation processes by means of microorganisms. This research has received competitive public grants from the European Commission, the Spanish Ministry of Economy and Competitiveness, the Valencia Region Government, and the University of Alicante.",institutionString:"University of Alicante",institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"83122",title:"New Perspectives on the Application of Chito-Oligosaccharides Derived from Chitin and Chitosan: A Review",doi:"10.5772/intechopen.106501",signatures:"Paul Edgardo Regalado-Infante, Norma Gabriela Rojas-Avelizapa, Rosalía Núñez-Pastrana, Daniel Tapia-Maruri, Andrea Margarita Rivas-Castillo, Régulo Carlos Llarena-Hernández and Luz Irene Rojas-Avelizapa",slug:"new-perspectives-on-the-application-of-chito-oligosaccharides-derived-from-chitin-and-chitosan-a-rev",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chitin-Chitosan - Isolation, Properties, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11670.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"83015",title:"Acute Changes in Lipoprotein-Associated Oxidative Stress",doi:"10.5772/intechopen.106489",signatures:"Ngoc-Anh Le",slug:"acute-changes-in-lipoprotein-associated-oxidative-stress",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Anh",surname:"Le"}],book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"83041",title:"Responses of Endoplasmic Reticulum to Plant Stress",doi:"10.5772/intechopen.106590",signatures:"Vishwa Jyoti Baruah, Bhaswati Sarmah, Manny Saluja and Elizabeth H. Mahood",slug:"responses-of-endoplasmic-reticulum-to-plant-stress",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11673",title:"Stem Cell Research",coverURL:"https://cdn.intechopen.com/books/images_new/11673.jpg",hash:"13092df328080c762dd9157be18ca38c",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"203598",title:"Ph.D.",name:"Diana",surname:"Kitala",slug:"diana-kitala",fullName:"Diana Kitala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12215",title:"Cell Death and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/12215.jpg",hash:"dfd456a29478fccf4ebd3294137eb1e3",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 29th 2022",isOpenForSubmission:!0,editors:[{id:"59529",title:"Dr.",name:"Ke",surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:21,paginationItems:[{id:"83115",title:"Fungi and Oomycetes–Allies in Eliminating Environmental Pathogens",doi:"10.5772/intechopen.106498",signatures:"Iasmina Luca",slug:"fungi-and-oomycetes-allies-in-eliminating-environmental-pathogens",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. Aldrich",slug:"a-review-of-application-strategies-and-efficacy-of-probiotics-in-pet-food",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82773",title:"Canine Transmissible Venereal Tumor: An Infectious Neoplasia in Dogs",doi:"10.5772/intechopen.106150",signatures:"Chanokchon Setthawongsin, Somporn Techangamsuwan and Anudep Rungsipipat",slug:"canine-transmissible-venereal-tumor-an-infectious-neoplasia-in-dogs",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82797",title:"Anatomical Guide to the Paranasal Sinuses of Domestic Animals",doi:"10.5772/intechopen.106157",signatures:"Mohamed A.M. Alsafy, Samir A.A. El-Gendy and Catrin Sian Rutland",slug:"anatomical-guide-to-the-paranasal-sinuses-of-domestic-animals",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82457",title:"Canine Hearing Management",doi:"10.5772/intechopen.105515",signatures:"Peter M. Skip Scheifele, Devan Marshall, Stephen Lee, Paul Reid, Thomas McCreery and David Byrne",slug:"canine-hearing-management",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82285",title:"Parvovirus Vectors: The Future of Gene Therapy",doi:"10.5772/intechopen.105085",signatures:"Megha Gupta",slug:"parvovirus-vectors-the-future-of-gene-therapy",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82170",title:"Equine Stress: Neuroendocrine Physiology and Pathophysiology",doi:"10.5772/intechopen.105045",signatures:"Milomir Kovac, Tatiana Vladimirovna Ippolitova, Sergey Pozyabin, Ruslan Aliev, Viktoria Lobanova, Nevena Drakul and Catrin S. Rutland",slug:"equine-stress-neuroendocrine-physiology-and-pathophysiology",totalDownloads:34,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:34,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}}]},subseriesFiltersForOFChapters:[{caption:"Animal Nutrition",value:20,count:3,group:"subseries"},{caption:"Animal Science",value:19,count:18,group:"subseries"}],publishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"10664",title:"Animal Reproduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",slug:"animal-reproduction",publishedDate:"May 25th 2022",editedByType:"Edited by",bookSignature:"Yusuf Bozkurt and Mustafa Numan Bucak",hash:"2d66af42fb17d0a6556bb9ef28e273c7",volumeInSeries:11,fullTitle:"Animal Reproduction",editors:[{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",slug:"animal-feed-science-and-nutrition-production-health-and-environment",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Amlan Kumar Patra",hash:"79944fc8fbbaa329aed6fde388154832",volumeInSeries:10,fullTitle:"Animal Feed Science and Nutrition - Production, Health and Environment",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10496",title:"Advanced Studies in the 21st Century Animal Nutrition",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10496.jpg",slug:"advanced-studies-in-the-21st-century-animal-nutrition",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"László Babinszky, Juliana Oliveira and Edson Mauro Santos",hash:"8ffe43a82ac48b309abc3632bbf3efd0",volumeInSeries:8,fullTitle:"Advanced Studies in the 21st Century Animal Nutrition",editors:[{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Animal Nutrition",value:20,count:2},{group:"subseries",caption:"Animal Reproductive Biology and Technology",value:28,count:4},{group:"subseries",caption:"Animal Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:755,paginationItems:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",biography:"Dr. Pravin Kendrekar, MSc, MBA, Ph.D., is currently a visiting scientist at the Lipid Nanostructure Laboratory, University of Central Lancashire, England. He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"19",type:"subseries",title:"Animal Science",keywords:"Animal Science, Animal Biology, Wildlife Species, Domesticated Animals",scope:"The Animal Science topic welcomes research on captive and wildlife species, including domesticated animals. The research resented can consist of primary studies on various animal biology fields such as genetics, nutrition, behavior, welfare, and animal production, to name a few. Reviews on specialized areas of animal science are also welcome.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11415,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null,series:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517"},editorialBoard:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",institutionString:null,institution:{name:"Universidade Paulista",institutionURL:null,country:{name:"Brazil"}}},{id:"191123",title:"Dr.",name:"Juan José",middleName:null,surname:"Valdez-Alarcón",slug:"juan-jose-valdez-alarcon",fullName:"Juan José Valdez-Alarcón",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBfcQAG/Profile_Picture_1631354558068",institutionString:"Universidad Michoacana de San Nicolás de Hidalgo",institution:{name:"Universidad Michoacana de San Nicolás de Hidalgo",institutionURL:null,country:{name:"Mexico"}}},{id:"161556",title:"Dr.",name:"Maria Dos Anjos",middleName:null,surname:"Pires",slug:"maria-dos-anjos-pires",fullName:"Maria Dos Anjos Pires",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS8q2QAC/Profile_Picture_1633432838418",institutionString:null,institution:{name:"University of Trás-os-Montes and Alto Douro",institutionURL:null,country:{name:"Portugal"}}},{id:"209839",title:"Dr.",name:"Marina",middleName:null,surname:"Spinu",slug:"marina-spinu",fullName:"Marina Spinu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLXpQAO/Profile_Picture_1630044895475",institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",institutionURL:null,country:{name:"Romania"}}},{id:"92185",title:"Dr.",name:"Sara",middleName:null,surname:"Savic",slug:"sara-savic",fullName:"Sara Savic",profilePictureURL:"https://mts.intechopen.com/storage/users/92185/images/system/92185.jfif",institutionString:'Scientific Veterinary Institute "Novi Sad"',institution:{name:'Scientific Veterinary Institute "Novi Sad"',institutionURL:null,country:{name:"Serbia"}}}]},onlineFirstChapters:{paginationCount:8,paginationItems:[{id:"83117",title:"Endothelial Secretome",doi:"10.5772/intechopen.106550",signatures:"Luiza Rusu",slug:"endothelial-secretome",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Luiza",surname:"Rusu"}],book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"83087",title:"Role of Cellular Responses in Periodontal Tissue Destruction",doi:"10.5772/intechopen.106645",signatures:"Nam Cong-Nhat Huynh",slug:"role-of-cellular-responses-in-periodontal-tissue-destruction",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82654",title:"Atraumatic Restorative Treatment: More than a Minimally Invasive Approach?",doi:"10.5772/intechopen.105623",signatures:"Manal A. Ablal",slug:"atraumatic-restorative-treatment-more-than-a-minimally-invasive-approach",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82735",title:"The Influence of Salivary pH on the Prevalence of Dental Caries",doi:"10.5772/intechopen.106154",signatures:"Laura-Cristina Rusu, Alexandra Roi, Ciprian-Ioan Roi, Codruta Victoria Tigmeanu and Lavinia Cosmina Ardelean",slug:"the-influence-of-salivary-ph-on-the-prevalence-of-dental-caries",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82357",title:"Caries Management Aided by Fluorescence-Based Devices",doi:"10.5772/intechopen.105567",signatures:"Atena Galuscan, Daniela Jumanca and Aurora Doris Fratila",slug:"caries-management-aided-by-fluorescence-based-devices",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"81894",title:"Diet and Nutrition and Their Relationship with Early Childhood Dental Caries",doi:"10.5772/intechopen.105123",signatures:"Luanna Gonçalves Ferreira, Giuliana de Campos Chaves Lamarque and Francisco Wanderley Garcia Paula-Silva",slug:"diet-and-nutrition-and-their-relationship-with-early-childhood-dental-caries",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"78064",title:"The Salivary Secretome",doi:"10.5772/intechopen.98278",signatures:"Luís Perpétuo, Rita Ferreira, Sofia Guedes, Francisco Amado and Rui Vitorino",slug:"the-salivary-secretome",totalDownloads:108,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"65334",title:"Introductory Chapter: Some Important Aspects of Root Canal Treatment",doi:"10.5772/intechopen.83653",signatures:"Ana Luiza de Carvalho Felippini",slug:"introductory-chapter-some-important-aspects-of-root-canal-treatment",totalDownloads:852,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Ana Luiza",surname:"De Carvalho Felippini"}],book:{title:"Root Canal",coverURL:"https://cdn.intechopen.com/books/images_new/7133.jpg",subseries:{id:"1",title:"Oral Health"}}}]},publishedBooks:{paginationCount:4,paginationItems:[{type:"book",id:"10794",title:"Potassium in Human Health",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",slug:"potassium-in-human-health",publishedDate:"July 20th 2022",editedByType:"Edited by",bookSignature:"Jie Tang",hash:"0fbab5c7b5baa903a6426e7bbd9f99ab",volumeInSeries:12,fullTitle:"Potassium in Human Health",editors:[{id:"181267",title:"Dr.",name:"Jie",middleName:null,surname:"Tang",slug:"jie-tang",fullName:"Jie Tang",profilePictureURL:"https://mts.intechopen.com/storage/users/181267/images/system/181267.png",institutionString:"Brown University",institution:{name:"Brown University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10835",title:"Autonomic Nervous System",subtitle:"Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",slug:"autonomic-nervous-system-special-interest-topics",publishedDate:"July 20th 2022",editedByType:"Edited by",bookSignature:"Theodoros Aslanidis and Christos Nouris",hash:"48ac242dc6c5073b2590a509c44628e2",volumeInSeries:14,fullTitle:"Autonomic Nervous System - Special Interest Topics",editors:[{id:"200252",title:"Dr.",name:"Theodoros",middleName:null,surname:"Aslanidis",slug:"theodoros-aslanidis",fullName:"Theodoros Aslanidis",profilePictureURL:"https://mts.intechopen.com/storage/users/200252/images/system/200252.png",institutionString:"Saint Paul General Hospital of Thessaloniki",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8430",title:"Neurodevelopment and Neurodevelopmental Disorder",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8430.jpg",slug:"neurodevelopment-and-neurodevelopmental-disorder",publishedDate:"November 27th 2019",editedByType:"Edited by",bookSignature:"Michael Fitzgerald",hash:"696c96d038de473216e48b199613c111",volumeInSeries:6,fullTitle:"Neurodevelopment and Neurodevelopmental Disorder",editors:[{id:"205005",title:"Dr.",name:"Michael",middleName:null,surname:"Fitzgerald",slug:"michael-fitzgerald",fullName:"Michael Fitzgerald",profilePictureURL:"https://mts.intechopen.com/storage/users/205005/images/system/205005.jpg",institutionString:"Independant Researcher",institution:{name:"Trinity College Dublin",institutionURL:null,country:{name:"Ireland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8797",title:"Adipose Tissue",subtitle:"An Update",coverURL:"https://cdn.intechopen.com/books/images_new/8797.jpg",slug:"adipose-tissue-an-update",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Leszek Szablewski",hash:"34880b7b450ef96fa5063c867c028b02",volumeInSeries:4,fullTitle:"Adipose Tissue - An Update",editors:[{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:126,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:13,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"3",title:"Bacterial Infectious Diseases",scope:"