IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
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IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
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Designed to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
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After a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
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Our innovative Book Series format brings you:
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Topic Focused Publications - Each topic showcases high impact subject areas
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Renowned Editorial Expertise - Series Editors, Topic Editors, and a team of international Board Members that permanently support each Book Series
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Fast Publishing - quick turnaround which is unique for book publishing
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The benefit of ISSN and ISBN for increased citation and indexing possibilities
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IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\n
IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
We invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
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Note: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5171",leadTitle:null,fullTitle:"Recent Advances in Drug Addiction Research and Clinical Applications",title:"Recent Advances in Drug Addiction Research and Clinical Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"Although it is well-accepted that drug addiction is a major public health concern, how we address it as a society continues to evolve as recent advances in the lab and clinic clarify the nature of the problem and influence our views. This unique collection of eight chapters reviews key findings on the neurobiology and therapeutics of addiction while capturing the diversity of perspectives that shape these concepts, which range from evolutionary biology to psychiatry to the legal system. This book discusses in depth how technological advances have led to important discoveries and how these discoveries, in turn, are increasingly being translated into clinical practice. It also presents avenues for future study that hold promise for the many affected by addiction.",isbn:"978-953-51-2492-4",printIsbn:"978-953-51-2491-7",pdfIsbn:"978-953-51-7286-4",doi:"10.5772/61445",price:119,priceEur:129,priceUsd:155,slug:"recent-advances-in-drug-addiction-research-and-clinical-applications",numberOfPages:230,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"d4d43741fe591f3102735d26db3c51a0",bookSignature:"William M. Meil and Christina L. Ruby",publishedDate:"July 14th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5171.jpg",numberOfDownloads:13531,numberOfWosCitations:29,numberOfCrossrefCitations:16,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:37,numberOfDimensionsCitationsByBook:2,hasAltmetrics:0,numberOfTotalCitations:82,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 6th 2015",dateEndSecondStepPublish:"October 27th 2015",dateEndThirdStepPublish:"January 31st 2016",dateEndFourthStepPublish:"April 30th 2016",dateEndFifthStepPublish:"May 30th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"87876",title:"Dr.",name:"William M.",middleName:null,surname:"Meil",slug:"william-m.-meil",fullName:"William M. Meil",profilePictureURL:"https://mts.intechopen.com/storage/users/87876/images/system/87876.jpg",biography:"Dr. William M. Meil is a full professor in the Psychology Department, Indiana University of Pennsylvania. Previously, he was a postdoctoral fellow at The Northeastern Ohio Universities Colleges of Medicine and Pharmacy. He received an MA in Psychology from The University of Hartford, Connecticut, and a Ph.D. in Psychology from Washington State University, Pullman, Washington. His research has spanned human and laboratory animal studies investigating the neurobiological basis of substance abuse and addiction. The current focus of his research is the examination of executive function, emotion regulation, and impulsivity as predictors of addictive behavior and recovery from addiction. He is the author of many peer-reviewed journal articles and book chapters.",institutionString:"Indiana University of Pennsylvania",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Indiana University of Pennsylvania",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"49482",title:"Dr.",name:"Christina",middleName:null,surname:"Ruby",slug:"christina-ruby",fullName:"Christina Ruby",profilePictureURL:"https://mts.intechopen.com/storage/users/49482/images/4946_n.jpg",biography:"Dr. Christina L. Ruby is an assistant professor of Biology at Indiana University of Pennsylvania. Prior to her current appointment, she held a postdoctoral fellowship at Mayo Clinic College of Medicine in Rochester, Minnesota. She earned her PhD in Physiology from Kent State University in Kent, Ohio. Christina has over 10 years of research experience studying the neurobiology of alcohol addiction. She has authored numerous peer-reviewed original research articles, reviews, and book chapters, some of which has been highlighted in the popular press. She has also provided several manuscript reviews for journals.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1131",title:"Global Health",slug:"global-health"}],chapters:[{id:"50263",title:"Circuits Regulating Pleasure and Happiness: A Focus on Addiction, Beyond the Ventral Striatum",doi:"10.5772/62707",slug:"circuits-regulating-pleasure-and-happiness-a-focus-on-addiction-beyond-the-ventral-striatum",totalDownloads:2274,totalCrossrefCites:5,totalDimensionsCites:10,hasAltmetrics:0,abstract:"A recently developed anatomical model describes how the intensity of reward-seeking and misery-fleeing behaviours is regulated. The first type of behaviours is regulated within an extrapyramidal cortical–subcortical circuit containing as first relay stations, the caudate nucleus, putamen and core of the accumbens nucleus. The second type of behaviours is controlled by a limbic cortical–subcortical circuit with as first stations, the centromedial amygdala, extended amygdala, bed nucleus of the stria terminalis and shell of the accumbens nucleus. We hypothesize that sudden cessation of hyperactivity of the first circuit results in feelings of pleasure and of the second circuit in feelings of happiness. The insular cortex has probably an essential role in the perception of these and other emotions. Motivation to show these behaviours is regulated by monoaminergic neurons projecting to the accumbens from the midbrain: dopaminergic ventral tegmental nuclei, adrenergic locus coeruleus and serotonergic upper raphe nuclei. The activity of these monoaminergic nuclei is in turn regulated through a ventral pathway by the prefrontal cortex and through a dorsal pathway by the medial and lateral habenula. The habenula has this role since the first vertebrate human ancestors with a brain comparable to that of modern lampreys. The lateral habenula promotes or inhibits reward-seeking behaviours depending upon the gained reward being larger or smaller than expected. It is suggested that the ventral pathway is essential for maintaining addiction based on the observation of specific cues, while the dorsal pathway is essential for becoming addicted and relapsing during periods of abstinence.",signatures:"Anton J.M. Loonen, Arnt F.A. Schellekens and Svetlana A. Ivanova",downloadPdfUrl:"/chapter/pdf-download/50263",previewPdfUrl:"/chapter/pdf-preview/50263",authors:[{id:"180500",title:"Prof.",name:"Anton J.M.",surname:"Loonen",slug:"anton-j.m.-loonen",fullName:"Anton J.M. Loonen"},{id:"183835",title:"Prof.",name:"Svetlana",surname:"Ivanova",slug:"svetlana-ivanova",fullName:"Svetlana Ivanova"},{id:"184995",title:"Dr.",name:"Arnt F.A.",surname:"Schellekens",slug:"arnt-f.a.-schellekens",fullName:"Arnt F.A. Schellekens"}],corrections:null},{id:"51028",title:"Epigenetics and Drug Abuse",doi:"10.5772/63952",slug:"epigenetics-and-drug-abuse",totalDownloads:2118,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Gene expression and inheritance are not only a function of the DNA code, but also epigenetic mechanisms that regulate DNA accessibility, transcription, and translation of the genetic code into a functional protein. Epigenetic mechanisms are invoked by life experiences, including stress and exposure to drugs of abuse, and the resulting changes in gene expression can be inherited by future generations. This chapter highlights recent research demonstrating epigenetic changes in response to drug exposure with a focus on three different mechanisms: DNA methylation, histone modification, and noncoding RNAs. We briefly describe each of these mechanisms and then provide key examples of drug-induced changes involving these mechanisms, as well as epigenetic manipulations that alter effects of drugs. We then review cutting-edge technologies, including viral-mediated gene transfer and gene editing, that are being used to manipulate epigenetic processes with temporal and cell-type specificity. We also describe and provide examples of intergenerational epigenetic modifications, a topic that has interesting implications for how addiction-related traits may be passed down across generations. Finally, we discuss how this research provides a greater understanding of drug addiction and may lead to novel molecular targets for preventions and interventions for drug abuse.",signatures:"Ryan M. Bastle and Janet L. Neisewander",downloadPdfUrl:"/chapter/pdf-download/51028",previewPdfUrl:"/chapter/pdf-preview/51028",authors:[{id:"180184",title:"Dr.",name:"Janet",surname:"Neisewander",slug:"janet-neisewander",fullName:"Janet Neisewander"},{id:"186395",title:"MSc.",name:"Ryan",surname:"Bastle",slug:"ryan-bastle",fullName:"Ryan Bastle"}],corrections:null},{id:"50638",title:"Alcohol Cues, Craving, and Relapse: Insights from Animal Models",doi:"10.5772/63105",slug:"alcohol-cues-craving-and-relapse-insights-from-animal-models",totalDownloads:1583,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Alcoholism is a chronic relapsing and remitting disorder, where relapse to drinking is often triggered by an intense desire for alcohol (craving) and the consequent motivation to obtain alcohol (seeking). Environmental stimuli (cues) associated with past alcohol use are believed to strongly contribute to relapse, as exposure to these cues can trigger intense feelings of craving and drive alcohol seeking. Over the past several decades, much progress has been made in identifying the neurobiological correlates of alcohol seeking and relapse. Much of this progress is owed to the development of animal models and advanced techniques to manipulate neural activity. In this chapter, we describe some of the most commonly used rodent models of alcohol intake and seeking as well as the methods used to identify the neural structures and circuits involved in alcohol-mediated behavior. Several of the most routinely identified brain structures in alcohol seeking are also described.",signatures:"Melanie M. Pina and Amy R. Williams",downloadPdfUrl:"/chapter/pdf-download/50638",previewPdfUrl:"/chapter/pdf-preview/50638",authors:[{id:"181013",title:"Dr.",name:"Melanie",surname:"Pina",slug:"melanie-pina",fullName:"Melanie Pina"},{id:"184842",title:"Ms.",name:"Amy",surname:"Williams",slug:"amy-williams",fullName:"Amy Williams"}],corrections:null},{id:"50688",title:"Dopamine and Alcohol Dependence: From Bench to Clinic",doi:"10.5772/63144",slug:"dopamine-and-alcohol-dependence-from-bench-to-clinic",totalDownloads:1963,totalCrossrefCites:5,totalDimensionsCites:12,hasAltmetrics:0,abstract:"Alcohol dependence, a chronic relapsing psychiatric disorder, is a major cause of mortality and morbidity. The role of dopamine in alcohol‐induced reward as well in the development of alcohol dependence is reviewed herein. Both preclinical and clinical studies have suggested that alcohol activates the mesolimbic dopamine system (defined as a dopamine projection from the ventral tegmental area (VTA) to the nucleus accumbens (NAc, i.e. ventral striatum)) leading to a euphoric sensation. Alcohol dependence is characterized by a disruption in the reward‐related brain areas including fewer dopamine D2 receptors in ventral striatum. Investigations of the underlying dopaminergic mechanisms involved during the development and maintenance of alcohol dependence could identify novel targets. Human and rodent experimental studies show that dopamine receptor antagonists, agonists and partial agonists as well as dopamine stabilizers influencing dopamine transmission, alter alcohol‐mediated behaviours and thus may be potential treatment targets for alcohol dependence. Although there exists promising preclinical results, the majority of placebo‐controlled randomized clinical trials with traditional dopamine antagonists and agonists have so far have been discouraging. Furthermore, the severe side-effect profiles of many of these compounds may limit their clinical use. Newer dopamine agents, such as partial agonists and dopamine stabilizers, attenuate alcohol‐mediated behaviours in rodents as well as humans. Preclinical as well as clinical studies have shown that substances indirectly targeting the mesolimbic dopamine system may be potential targets for attenuation of alcohol reward. Collectively, the data reviewed herein may contribute to further understanding the complex mechanisms involved in development of alcohol dependence and we suggest that the newer dopamine agents as well as indirect modulators of dopamine signalling deserve to be further evaluated for treatment of alcohol dependence.",signatures:"Nitya Jayaram‐Lindström, Mia Ericson, Pia Steensland and Elisabet Jerlhag",downloadPdfUrl:"/chapter/pdf-download/50688",previewPdfUrl:"/chapter/pdf-preview/50688",authors:[{id:"180721",title:"Associate Prof.",name:"Elisabet",surname:"Jerlhag",slug:"elisabet-jerlhag",fullName:"Elisabet Jerlhag"}],corrections:null},{id:"50615",title:"Contribution of Noradrenaline, Serotonin, and the Basolateral Amygdala to Alcohol Addiction: Implications for Novel Pharmacotherapies for AUDs",doi:"10.5772/62843",slug:"contribution-of-noradrenaline-serotonin-and-the-basolateral-amygdala-to-alcohol-addiction-implicatio",totalDownloads:1818,totalCrossrefCites:1,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Alcohol use disorders (AUDs) constitute one of the 10 leading causes of preventable deaths worldwide. To date, there are only a few Food and Drug Administration (FDA)‐approved medications for AUDs, all of which are only moderately effective. The development of improved and effective strategies for the management of AUDs is greatly needed. This review focuses on understanding the neurobiological basis of alcohol addiction with a special emphasis on the role of serotonin (5‐hydroxytryptamine, 5‐HT) and noradrenaline (NE) in AUDs and sheds light on their complex interplay in the basolateral amygdala (BLA)––a brain region widely implicated in addiction. There is a significant evidence to support the role of the amygdala in stress‐induced negative emotional states resulting from withdrawal from alcohol; in fact, it has been hypothesized that this leads to craving and relapse. Dysregulation of 5‐HT and NE signaling in the BLA have been proposed to alter affective behavior, memory consolidation, and most importantly increase the propensity for addiction to alcohol and other common drugs of abuse. Improving deficits in 5‐HT and NE receptor signaling may provide ideal targets for the treatment of AUDs.",signatures:"Omkar L. Patkar, Arnauld Belmer and Selena E. Bartlett",downloadPdfUrl:"/chapter/pdf-download/50615",previewPdfUrl:"/chapter/pdf-preview/50615",authors:[{id:"180222",title:"Prof.",name:"Selena",surname:"Bartlett",slug:"selena-bartlett",fullName:"Selena Bartlett"},{id:"180390",title:"Mr.",name:"Omkar",surname:"Patkar",slug:"omkar-patkar",fullName:"Omkar Patkar"},{id:"180391",title:"Dr.",name:"Arnauld",surname:"Belmer",slug:"arnauld-belmer",fullName:"Arnauld Belmer"}],corrections:null},{id:"51529",title:"Substance Abuse Therapeutics",doi:"10.5772/64264",slug:"substance-abuse-therapeutics",totalDownloads:1337,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter provides a broad overview of therapies for substance abuse. These therapies are understood in the context of the history of drug use in the United States and factors that influenced the expansion and regulation of substance use. This is followed by a discussion of how the complexity of these factors was associated with difficulties in understanding substance misuse and created challenges to the creation of effective treatment systems. The chapter reviews the moral and disease models of addiction before discussing the diagnosis of substance-related disorders. The chapter describes major treatment approaches and their efficacy.",signatures:"John Andrew Mills",downloadPdfUrl:"/chapter/pdf-download/51529",previewPdfUrl:"/chapter/pdf-preview/51529",authors:[{id:"180728",title:"Dr.",name:"John A.",surname:"Mills",slug:"john-a.-mills",fullName:"John A. Mills"}],corrections:null},{id:"50569",title:"Dual Diagnosis Patients First Admitted to a Psychiatric Ward for Acute Psychiatric Patients: 2-Year Period 2003–2004 versus 2013–2014",doi:"10.5772/63102",slug:"dual-diagnosis-patients-first-admitted-to-a-psychiatric-ward-for-acute-psychiatric-patients-2-year-p",totalDownloads:1032,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Dual diagnosis (DD) is the coexistence of severe mental illness (SMI) and substance use disorder (SUD). The increase of DD observed in recent years has important implications for mental health services organization. The aim of this study is to assess the prevalence and features of DD over a decade, comparing the periods 2003–2004 and 2013–2014. We performed a retrospective study retrieving sociodemographic and clinical data from the medical records of patients at their first admission to the Psychiatric Ward of University Hospital “Maggiore della Carità” in Novara, Italy. Patients with SMI and comorbid SUD (SMI-SUD) and patients with SMI without comorbidity (SMI) were compared in the two periods, 2003–2004 versus 2013–2014. SMI-SUD patients in both 2-year periods were more likely to be male, younger, unemployed, living with parents (or alone, for the 2013–2014 period) rather than with a family of their own, and single (or divorced, in 2003–2004). The 2003–2004 patients were more frequently diagnosed with a personality disorder, whereas the 2013–2014 patients had mixed diagnoses. We have found differences in the possible predictors of substance abuse in the two periods as well: in both periods, male gender was associated with an increased risk of DD, whereas age >61 years was associated with decreased risk. Only in the first period (2003–2004) was having a university degree associated with a decreased risk of DD, whereas the diagnosis of a personality disorder was associated with an increased risk of DD; on the contrary, in the second period (2013–2014), living in a protective environment was associated with a decreased risk of DD. The identification of changes in the prevalence of first admission DD patients and their clinical and sociodemographic features may help to highlight an evolving pattern of substance use and to identify possible risk factors that may be the target of prevention and treatment approaches.",signatures:"Carla Gramaglia, Ada Lombardi, Annalisa Rossi, Alessandro Feggi,\nFabrizio Bert, Roberta Siliquini and Patrizia Zeppegno",downloadPdfUrl:"/chapter/pdf-download/50569",previewPdfUrl:"/chapter/pdf-preview/50569",authors:[{id:"179172",title:"Prof.",name:"Patrizia",surname:"Zeppegno",slug:"patrizia-zeppegno",fullName:"Patrizia Zeppegno"},{id:"180447",title:"Dr.",name:"Carla",surname:"Gramaglia",slug:"carla-gramaglia",fullName:"Carla Gramaglia"},{id:"180448",title:"Dr.",name:"Ada",surname:"Lombardi",slug:"ada-lombardi",fullName:"Ada Lombardi"},{id:"180449",title:"Dr.",name:"Annalisa",surname:"Rossi",slug:"annalisa-rossi",fullName:"Annalisa Rossi"},{id:"180451",title:"Dr.",name:"Alessandro",surname:"Feggi",slug:"alessandro-feggi",fullName:"Alessandro Feggi"}],corrections:null},{id:"51103",title:"Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function",doi:"10.5772/63389",slug:"review-of-current-neuroimaging-studies-of-the-effects-of-prenatal-drug-exposure-brain-structure-and-",totalDownloads:1408,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Neuroimaging tools have provided novel methods for understanding the impact of prenatal drug exposure on brain structure and function and its relation to development and behavior. Information gained from neuroimaging studies allows for the investigation of how prenatal drug exposure alters the typical developmental trajectory. The current prevalence and characteristics of prenatal drug exposure and its implications for vulnerable periods of brain development are reviewed. Structural and functional neuroimaging methods are introduced with examples of how study results from prenatal alcohol, cocaine, marijuana, and tobacco exposure further our understanding of the neurodevelopment impact of prenatal drug exposure. Prenatal drug neuroimaging studies have advanced our understanding of mechanisms and functional deficits associated with prenatal drug exposure. Studies have identified brain circuits associated with the default mode network, inhibitory control, and working memory that show differences in function as a result of prenatal drug exposure. The information gained from studies of prenatal drug exposure on brain structure and function can be used to make connections between animal models and human studies of prenatal drug exposure, identify biomarkers of documented effects of prenatal drug exposure on behavior, and inform prevention and intervention programs for young children.",signatures:"Jennifer Willford, Conner Smith, Tyler Kuhn, Brady Weber and Gale Richardson",downloadPdfUrl:"/chapter/pdf-download/51103",previewPdfUrl:"/chapter/pdf-preview/51103",authors:[{id:"181729",title:"Ph.D.",name:"Jennifer",surname:"Willford",slug:"jennifer-willford",fullName:"Jennifer Willford"},{id:"185029",title:"Mr.",name:"Conner",surname:"Smith",slug:"conner-smith",fullName:"Conner Smith"},{id:"185030",title:"Mr.",name:"Tyler",surname:"Kuhn",slug:"tyler-kuhn",fullName:"Tyler Kuhn"},{id:"186946",title:"Mr.",name:"Brady",surname:"Weber",slug:"brady-weber",fullName:"Brady Weber"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10348",title:"Addictions",subtitle:"Diagnosis and Treatment",isOpenForSubmission:!1,hash:"4b66187e9866019abbb18183e4364d2b",slug:"addictions-diagnosis-and-treatment",bookSignature:"William M. Meil and John A. Mills",coverURL:"https://cdn.intechopen.com/books/images_new/10348.jpg",editedByType:"Edited by",editors:[{id:"87876",title:"Dr.",name:"William M.",surname:"Meil",slug:"william-m.-meil",fullName:"William M. 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\r\n\tThe personality traits cover the broad range of psychological characteristics of healthy and ill persons. The pathological personality features may be regarded as risk factors for some psychopathological disorders and can lead to their appearance in the future. The main task of a psychiatrist's work concerns the exact and timely diagnosis of mental illness and its treatment. The diagnosis itself includes the understanding of the premorbid personality structure, and determination of the mental disorder prognosis based on the premorbid personality traits analysis. In this context, the role and significance of premorbid personality traits can't be exaggerated.
\r\n
\r\n\tThe current book aims at addressing all mentioned issues and will include three main topics. In the first topic, the history of personality features description will be presented in the full variety. The second topic will present the data on the relationships between different personality traits, and comorbid psychopathological disorders following from certain personality constructs. The third topic will present the different therapeutic approaches to pathological personality types and comorbid psychopathological disorders. \r\n\t
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1. Introduction
The Fungal Kingdom encompasses a diverse and broad group of organisms that includes microscopic yeasts, as well as rusts, smuts, mildews, molds, and mushrooms. These organisms are neither plants nor animals and have been placed in a group of their own because of the distinct chemical composition of their plasma membrane and cell wall, their existence as unicellular and complex multicellular organisms, their heterotrophic lifestyle involving the intake of nutrients from other organisms for their metabolism, and their ability to reproduce both asexually and sexually [1]. Fungi are eukaryotic organisms believed to have descended from an ancestor they shared with animals that lived roughly a billion years ago [2]. The earliest fungal fossils are from the Ordovician, 460–455 million years ago [3], but some scientists believe that fungi may even be 3.5 billion years old [3]. Notably, the first vascular land plants only appeared approximately 425 million years ago, and fungi may have played an essential role in the colonization of land by these early plants [3].
Since their emergence, fungi have evolved into a major taxonomic kingdom. So far, about 150,000 species of fungal organisms have been described [4]. However, studies using molecular methods have estimated that the number of fungal species on Earth may amount to 3.5–5.1 million [5]. This number is probably comparable to that of all animal species on our planet and substantially more than that of all plant species in our biodiversity [5]. Fungi thrive in almost all habitats and are only surpassed by bacteria in their ability to withstand and adapt to extreme environmental conditions [6]. Tropical regions have the highest diversity of fungi [7], and finds of novel, unusual species in these regions are regularly reported. An example is the discovery of the ascomycete Pseudotulostoma volvata in the Guiana Shield described in 2001 [8]. In addition, exploration of deserts and arctic regions has yielded an unexpectedly large fungal diversity [9, 10].
Most fungi are free-living in nature, where they function—together with bacteria—as decomposers in the energy cycle, breaking down organic matter such as leaf litter, animal excrements, wood, and dead animals, and releasing carbon, oxygen, nitrogen, and phosphorus into the soil and the atmosphere to be used by other organisms [11]. This makes fungi vital for the health of ecosystems and the entire biodiversity. Furthermore, various fungal species were at the basis of commercially successful drugs. The common indoor fungus Penicillium chrysogenum produced penicillin, the first of a series of β-lactam antibiotics that revolutionized the medical world [12]. Tolypocladium inflatum parasitizes on insects and gave cyclosporine that is commonly used as an immunosuppressant after bone marrow and organ transplants [13]. And the specific HMG-CoA reductase-inhibiting statins were first discovered as secondary metabolites in the soil-borne fungus Aspergillus terreus and became important LDL-lowering compounds that reduce the risk of arterial blockage and developing a heart attack, stroke, and diabetes mellitus [14].
Other fungi such as the baker’s or brewer\'s yeast Saccharomyces cerevisiae, along with various mushrooms, have been found useful as food. Saccharomyces cerevisiae converts carbohydrates into carbon dioxide and alcohols through fermentation. The products of this reaction have been used in baking and the production of alcoholic beverages for thousands of years [15]. Saccharomyces cerevisiae has also served as a model organism for studying human genetics including DNA sequences involved in disease and aging [16]. Notably, this fungal species was the first eukaryotic organism to have its genome completely sequenced [17]. Another landmark model fungal species for scientific research was the pink mold Neurospora crassa. Studies with this organism revealed for the first time that genes control the expression of enzymes and that one gene regulates one enzyme [18].
On the other hand, many fungi—such as molds on food or pathogenic spores—are less desirable. Currently, over 8000 fungal species are known to be detrimental to plants, causing, among others, smut and rust, and routinely destroying crops and plants such as beans, barley, and pine trees [4]. And around 300 fungi cause disease in humans [4]. Some, like yeast species in the genus Malassezia cause relatively harmless superficial infections such as pityriasis versicolor [19]. Others, however—like several yeast species in the genus Candida—are the causative agents of potentially fatal infections in immunocompromised individuals [20]. And certain species in the genus Aspergillus produce aflatoxins on improperly stored staple commodities such as peanuts, maize, rice, and cassava, which have been associated with liver cancer [21].
This monograph first presents some important characteristics and the taxonomy of fungi, clarifies the significance of fungi to humans, then deals with the different types of mycoses and their treatment; subsequently focuses on Suriname and elaborately addresses nine plants used for treating fungal infections in Suriname; and concludes with a few remarks on the importance of these plants for medicine.
2. Characteristics of fungi, their taxonomy, and their significance to humans
As mentioned above, fungi are eukaryotic, non-vascular, non-motile and heterotrophic organisms that include yeasts, rusts, smuts, mildews, molds, and mushrooms [22]. These organisms are classified under the Kingdom Fungi, next to the Kingdoms of bacteria, protists, plants, and animals [22]. Fungi are among the most widely distributed organisms on Earth [22]. Many are free-living in soil or water, performing essential ecological functions, while others form parasitic or symbiotic relationships with plants or animals [22]. A considerable number of species is also of great economic and medical importance [22]. Hereunder, a few notable characteristics of fungi are addressed, as well as some aspects of their taxonomy and their significance to humans.
2.1 Characteristics
Although, the numerous fungal species on Earth have widely diverse habitats and characteristics, they have some key aspects in common which make them sufficiently distinct from other organisms to place them in their own biological kingdom [22]. The main differences with the other kingdoms are differences in cell structure, body organization, mode of acquiring nutrition, and means of reproduction. The most important characteristics of the fungal kingdom have elaborately been reviewed in reference [22].
Firstly, fungi are eukaryotes and have their cells surrounded by an inner plasma membrane and an outer cell wall, similarly to bacterial cells and plant cells [23, 24]. However, in fungal cells, both these cellular constituents have a unique composition and distinct properties when compared to the members of the other biological kingdoms. The fungal cell wall contains adhesins and receptors which mediate the interactions of the organisms with the external environment [24]. Furthermore, it helps the organisms to maintain their structure, to protect the cells from various types of stress (particularly osmotic changes), and to guard the integrity of the cellular content [24]. Importantly, the fungal cell wall is mainly made up of glucans, chitin, and glycoproteins instead of cellulose as is the case with plant cells [24]. These ingredients are not present in human cells, providing the opportunity of selective antifungal therapies [24].
The plasma membrane of fungi contains, among others, transport proteins and proteins involved in signal transduction, cell wall and cytoskeleton synthesis, as well as various glycerophospholipids, sphingolipids, and sterols [23]. The main component of the fungal plasma membrane is the unique sterol ergosterol instead of cholesterol which is the major sterol in animal cells [23]. This distinction has therapeutically been exploited by identifying antifungal drugs that target ergosterol synthesis, perturbing the integrity of the fungal cell membrane [23].
Secondly, fungi can consist of a single cell as in the case of yeasts, or multiple cells as in the case of, for instance, mushrooms [22]. Yeasts such as the baker’s or brewer\'s yeast Saccharomyces cerevisiae are estimated to constitute 1% of all described fungal species [25]. They have probably evolved from multicellular ancestors [26], and some species can develop multicellular characteristics by forming strings of connected budding cells known as pseudohyphae or false hyphae [27]. Yeast species typically measure 3–4 μm in diameter, but some can reach a size of 40 μm [28].
The majority of fungal species are multicellular and is generally known as molds. A few well-known species are those in the genera Aspergillus (commonly found on compost and other decaying vegetable matter as well as stored grain [29]), Penicillium (of major importance in food spoilage and food and drug production [30]), Rhizopus (found on decaying fruit and vegetables, animal feces, and old bread [31]), and Trichophyton (the causative agents of tineas such as athlete’s foot, ringworm, jock itch, and similar infections of the nail, beard, skin and scalp [32]).
The cells of multicellular fungal species are grouped to form tubular, elongated, and filamentous structures called hyphae of 2–10 μm in diameter and up to several centimeters in length, and may contain multiple nuclei [22]. They extend by branching at their tips, and several hyphae mesh together to form the fungal body or mycelium [22]. There are in general specialized hyphal structures for nutrient uptake from living hosts such as the haustoria in most fungal phyla and the arbuscules of several mycorrhizal fungi [33]. Of note, some fungal species can exist as unicellular and multicellular forms, depending on the temperature [34]. An example of such a dimorphic fungus is Talaromyces marneffei, an important cause of opportunistic infections in individuals with HIV/AIDS-related immunodeficiency that grows as a mold at room temperature and as a yeast at human body temperature [35].
Furthermore, fungi lack chlorophyll and cannot conduct photosynthesis, acquiring food by absorbing nutrients from organic substances around them which they break down outside their body by digestive enzymes secreted from the tips of their hyphae [22]. Depending on the species, this occurs through saprophytism, parasitism, or symbiotic relationships. Saprophytic fungi feed on dead organic substances. Examples are species in the genera Aspergillus [29], Penicillium [30], and Rhizopus [31]. Parasitic fungi obtain their nutrition by living on other living organisms (plants or animals) and absorbing nutrients from their host. Examples are Taphrina which causes deformities in flowering plants such as leaf curl disease [36] and witches’ brooms [37], as well as Puccinia that causes leaf rust in, among others, wheat [38]. And symbiotic fungi such as lichens and mycorrhiza have an interdependent relationship with other species in which both are mutually benefited. Lichens are the symbiotic association between algae and fungi [39]. A mycorrhiza is a symbiotic association between a green plant and a fungus. The plant makes organic molecules such as sugars by photosynthesis and supplies them to the fungus, and the fungus provides the plant with water and minerals from the soil such as phosphorus [40].
Lastly, fungi are capable of reproducing by both asexual and sexual means. Relatively simple, single-celled fungi like Saccharomyces cerevisiae reproduce vegetatively by budding [22, 41]. Other forms of vegetative reproduction in fungi are by fission or fragmentation [22, 41]. The majority of multicellular fungal species reproduce asexually through the formation of diploid spores formed by mitosis and called conidia or zoospores or sporangiospores [22, 41]. However, in most mushrooms, puffballs, and toadstools, sexual reproduction takes place by spores (ascospores, basidiospores, and oospores) formed through meiosis [22, 41]. The haploid spores germinate into primary mycelia which form secondary mycelia when they come into contact with each other, after which the nuclei fuse and give rise to cells with the original number of chromosomes [22, 41]. On the other hand, in some fungi, the fusion of two haploid hyphae does not result in the formation of a diploid cell but first in the formation of an intermediate stage called the dikaryophase, which is followed by the formation of diploid cells [22, 41].
Sexual reproduction is an important source of genetic variability, allowing fungi to adapt to new environments. Another strategy of some fungi to generate genetic diversity—often because of stress such as antifungal therapy—is the formation of polyploid/aneuploid nuclei. Dimorphic fungi can switch between a yeast phase and a hyphal phase in response to environmental conditions. An example is the above-mentioned species Talaromyces marneffei [35], probably one of the world’s most feared fungi that can cause potentially lethal talaromycosis [42]. This is a systemic opportunistic infection in immunocompromised individuals that is characterized by fever, skin lesions, anemia, generalized lymphadenopathy, and hepatomegaly [42].
2.2 Taxonomy
The taxonomy of fungi is regularly revised as novel molecular data and DNA comparisons allow for phylogenetic analyses that replace older classifications that mainly use morphological features and reproductive characteristics. Primarily based on the characteristics of sexual reproductive structures, the Fungal Kingdom is currently subdivided into seven phyla: the Microsporidia, the Chytridiomycota, the Blastocladiomycota, the Neocallimastigomycota, the Glomeromycota, the Ascomycota, and the Basidiomycota [43]. The Microsporidia are spore-forming unicellular endobiotic fungi of 1–40 μm that parasitize on animals and humans. Roughly 1500 of the known fungal species belong to this phylum. Several species such as members of the genera Enterocytozoon and Encephalitozoon can cause microsporidiosis in immunocompromised individuals, an opportunistic infection characterized by diarrhea and wasting [44].
The Chytridiomycota, commonly known as chytrids, encompasses approximately 900 identified species that can be encountered in a wide range of aquatic and terrestrial habitats throughout the world. They produce zoospores that are capable of active movement through aqueous phases with a single flagellum. Chytrids are saprobic, feeding on decayed organic matter. Some, like Batrachochytrium dendrobatidis, parasitize on animals. Batrachochytrium dendrobatidis is the causative agent of chytridiomycosis, an infectious disease that is responsible for dramatic declines and even extinctions in amphibian populations in many countries [45].
The Blastocladiomycota are also posteriorly uniflagellated zoosporic fungi that live as saprotrophs primarily in freshwater and soil, and they parasitize on all eukaryotic groups. At this moment, less than 200 species have been described. Whereas their close relatives, the chytrids, mostly exhibit zygotic meiosis (i.e., meiosis of the zygote immediately after karyogamy, resulting in the production of several haploid cells), the blastocladiomycetes undergo sporic meiosis (i.e., meiosis resulting in the production of haploid spores that can develop directly into new, haploid, individuals). A well-known species is Paraphysoderma sedebokerense, a highly destructive pathogen of algae grown in mass cultures for biofuels and pharmaceuticals [46].
The Neocallimastigomycota are anaerobic organisms that live in the digestive system of larger herbivorous mammals [47] as well as that of humans [48] where they play an essential role in the digestion of fibre. They are also closely related to chytrids and form zoospores that are posteriorly uniflagellate or polyflagellate. However, neocallimastigomycetes lack mitochondria but contain hydrogenosomes of mitochondrial origin. This phylum consists of about 20 species that are grouped in only one family, the Neocallimastigaceae. The type species is Neocallimastix frontalis that has been studied as a means of large-scale cellulase production [49].
The Glomeromycota include only one class, the Glomeromycetes, and contain approximately 230 described terrestrial species that are widely distributed in soils worldwide. All known Glomeromycota species reproduce asexually. Many form highly branched arbuscular mycorrhizas with the thalli of bryophytes and the roots of vascular land plants [50, 51]. These mutualistic relationships are beneficial for both participants, because the fungus acquires carbohydrates formed by the plant, and the plant acquires nitrogen, phosphorous, and other minerals produced by the fungus [50, 51]. One of the most distinctive features of glomeromycetes is the arbuscules, the points of exchange between fungus and plants [50, 51].
The Ascomycota, commonly known as sac fungi or ascomycetes, is the largest phylum in the fungal kingdom, harboring over 64,000 species. Members of this phylum reproduce sexually or meiotically via the production of non-motile ascospores inside a microscopic sac-like structure called an ascus, the defining feature of this group of fungi. Because the products of meiosis—the ascospores—are retained within the ascus, ascomycetes such as Neurospora crassa have been used—as mentioned before—for elucidating the principles of genetics and heredity [18]. Many species of Ascomycota also (or exclusively) produce spores called conidia through an asexual or mitotic process [52]. The Ascomycota include fungal species that are of particular importance as sources of antibiotics and for a variety of industrial applications, but also because of their pathogenicity towards humans, animals, and/or plants (see, for instance, references [53, 54]). A few examples are fission yeasts in the genus Schizosaccharomyces, the unicellular yeast genera Saccharomyces and Candida, as well as morels, some edible mushrooms, truffles, and various filamentous ascomycetes in the genera Aspergillus, Penicillium, Fusarium, and Claviceps [53, 54].
The Basidiomycota, also known as the club fungi or basidiomycetes, include mushrooms (such as the champignon mushroom Agaricus bisporus; Figure 1), puffballs, stinkhorns, bracket fungi, other polypores, jelly fungi, boletes, chanterelles, earth stars, smuts, bunts, rusts, mirror yeasts, and the human pathogenic yeast genus Cryptococcus. With over 31,500 species described species, this group is the second largest of the Fungal Kingdom and constitutes, together with the Ascomycota, the subkingdom Dikarya (often referred to as the ‘higher fungi’). Well-known basidiomycetes are species in the genus Puccinia that cause rust in many economically important crops [55], Ustilago maydis that causes smut on maize [56], Malassezia yeasts that are mainly associated with certain skin conditions in humans [57], as well as the opportunistic human yeast Cryptococcus neoformans that usually infects the lungs or the central nervous system but sometimes also other parts of the body [58]. All Basidiomycota are filamentous fungi composed of hyphae (except for basidiomycota-yeast), and reproduce sexually via the formation of specialized club-shaped end cells called basidia that produce meiospores called basidiospores [59]. Another distinctive anatomical feature of this fungal phylum is the presence of clamp connections, hook-like structures which ensure that each hyphal cell or segment of hypha receives a set of different nuclei obtained through the mating of hyphae of differing sexual types to create genetic variation [60].
Figure 1.
The champignon mushroom Agaricus bisporus (from: https://images.app.goo.gl/Ahbf55DQRixrBZfw6).
2.3 Significance of fungi to humans
Humans have been aware of the existence of fungi—albeit indirectly in some cases—since they learned to prepare wine from grapes and bake bread. Ancient peoples were also familiar with the devastating effects of fungi on their crops but attributed these ravages to the wrath of the gods. The Romans had even designated a particular deity, Robigus, as the god of blight and wheat rust, and sacrificed a dog during the Robigalia, a festival held in his honor on April 25 to appease him and protect their grain fields from the disease [61]. Later, many devastating plant pathogenic fungal species have been identified. Examples are Glomerella cingulata that causes anthracnose (plant canker) and fruit rotting diseases on, among others, cereals, grasses, legumes, fruits, vegetables, perennial crops, and trees [62] (Figure 2); Botrytis cinerea, a necrotrophic fungus that is responsible for botrytis bunch rot or grey mould on wine grapes [63]; Gibberella pulicaris, a fungal pathogen that infects, among others, potato, strawberry, hop, and alfalfa [64]; and Podosphaera fuliginea, that causes powdery mildew on cucurbits [65].
Figure 2.
Anthracnose on grapes caused by the plant pathogenic fungus Glomerella cingulata (from: https://images.app.goo.gl/rBcDiAFTKCBwLQXH8).
Several fungal species also cause disease in humans. These are dealt with in the next section. On the other hand, various fungi have a long medicinal use and have been at the basis of many important therapeutics. For instance, ‘Ötzi the ice man’, who had lived between 3400 and 3100 BC during the Copper Age and had been found frozen in the Ötztal Alps (Austria) in 1991, carried pieces of fungus among his personal effects which he presumably had used to treat the parasites in his gastrointestinal tract [66]. Later, fungi made breakthrough contributions to medicine. A few notable examples have been given above and include the β-lactam antibiotics from Penicillium chrysogenum [12], the immune-suppressant drug cyclosporine from Tolypocladium inflatum [13], and the blood cholesterol-lowering statins from Aspergillus terreus [14].
Other drugs of fungal origin are the oral antifungal agent griseofulvin from Penicillium griseofulvum that is efficacious against fungal infections of the skin, nails, and scalp [67]; micafungin, a synthetic analogue from a lead compound produced by Coleophoma empetri for treating invasive fungal infections including candidemia, abscesses, and esophageal candidiasis [68]; and sordarin and its analogues isolated from Sordaria araneosa that target protein synthesis and are active against yeasts and yeast-like fungi [69]. Penicillium griseofulvum occurs on cereals, nuts, and stored fruits [70], Coleophoma empetri causes cranberry fruit rot disease [71], and Sordaria species are commonly found in the feces of herbivores [72]. Furthermore, the polyketide zaragozic acid also known as squalestatin produced by common soil fungi in the genus Phoma—that includes species causing heart rot and blight of beets, and dry rot of sweet potato [73]—potently inhibited mammalian squalene synthase, the rate-limiting enzyme in sterol biosynthesis, thereby blocking cholesterol production to a comparable extent as statins [74].
As well, the sympathicomimetic ergot alkaloids produced by the ergot fungus Claviceps purpurea can constrict the blood vessels around the brain and are therefore very efficacious in relieving migraine headaches [75]. However, these compounds were responsible for dreadful epidemics of poisoning in the Middle Ages, when many individuals developed ergotism after the consumption of bread made from rye or wheat contaminated with this fungal species [76]. The syndrome was popularly known as ‘St. Anthony’s fire’ because it caused intensely painful burning sensations in the limbs and extremities, along with painful seizures and spasms, diarrhea, mental effects including mania or psychosis, headaches, nausea and vomiting, and eventually gangrene, neurological diseases, and death [76]. Due to its specific uterotonic activity, Claviceps purpurea was also used to speed up child deliveries but it claimed instead many additional fatalities [76].
Several ‘domesticated’ fungi have become essential in modern households and industrial processes. As mentioned above, Saccharomyces cerevisiae is instrumental in winemaking, baking, and brewing [15]. The trichocomaceous family members Penicillium roqueforti and Penicillium camemberti are indispensable for the proper ripening of the blue-veined sheep’s milk cheese Roquefort and the cow’s milk cheese Camembert, respectively [77]. The champignon mushroom Agaricus bisporus is one of the most widely consumed mushrooms in the world [78]. The morel mushroom Morchella esculenta and several species of truffles in the genus Tuber are highly appreciated items in haute cuisine [79]. And the mycoproteins derived from the mycelia of the filamentous soil fungus Fusarium venenatum serve as the starting materials for high-protein and high-fiber foods as alternatives to meat and substitutes for fat in dairy products and cereal in breakfast cereals and snacks [80].
Furthermore, to meet the increasing worldwide demands of citric acid, malic acid, and lactic acid, these compounds are currently produced by fermentation with Aspergillus niger and several species in the genera Candida [81], Aspergillus [82], and Rhizopus [83], respectively. Certain fungi are also industrially used to produce enzymes on a large scale. A few examples are lipases for the food, detergent, and pharmaceutical sectors [84]; cellulase for the production of cellulose as veterinary foods, wood and paper, fibers and clothes, cosmetics, and pharmaceutical excipients [85]; and amylases for the food, textile, paper, and detergent industries [86].
3. Fungal infections, epidemiology, and treatment
As mentioned before, there are tens of thousands if not millions of different species of fungus [1, 5]. Many live in air, soil, water, and plants, but some live naturally in the human body [1, 5]. And indeed, only a relative minority—about 300—is pathogenic to humans, and this usually occurs when the invading fungus takes over an area of the body and cannot be effectively dealt with by the immune system [20, 21]. Examples of common types of fungal infections in humans are athlete’s foot, vaginal yeast infections, Candida toenail infections and diaper rash, jock itch, and ringworm [20, 21]. Familiar symptoms of many fungal infections include skin changes, redness, itching, and cracking or peeling skin [20, 21]. Fortunately, these infections are usually not very serious if treated promptly and properly [22, 23], often with over-the-counter or prescription creams [22, 23]. On the other hand, fungal infections are more severe in individuals with a weakened immune system [22, 23]. The same holds for fungal infections in people taking antibiotics [22, 23], undergoing treatment for cancer [22, 23], or suffering from diabetes mellitus [22, 23]. These infections may require additional methods of treatment [5, 6].
3.1 Types of fungal infections
Fungal infections or mycoses can be classified on the basis of the route of acquisition of the pathogen, the degree of virulence exhibited by the fungus, and the site of the infection [20, 21]. The route of acquisition of a fungal infection may either be exogenous or endogenous, i.e., resulting from airborne, cutaneous, or percutaneous fungi, or colonization by a member of the normal flora or reactivation of a previous infection [20, 21]. With regards to the classification based on virulence, primary pathogens can establish infections in normal hosts while opportunistic pathogens cause disease in individuals with compromised host defense mechanisms [20, 21]. More often, fungal infections are classified by the site of the infection, i.e., as superficial, cutaneous, subcutaneous, or systemic (deep) infections depending on the type and degree of tissue involvement and the host response to the pathogen [20, 21].
Superficial mycoses are fungal infections of the skin, hair, and nails that invade only the stratum corneum and the superficial layers of the skin and neither invade living tissue nor provoke an immune response by the host. A well-known superficial fungal infection is pityriasis versicolor, a condition characterized by light spots on the chest, back, upper arms, and legs that are usually caused by Malassezia globosa, a yeast species that normally lives in the pores of the skin [19].
Cutaneous mycoses (also referred to as dermatophytoses or dermatomycoses) are fungal infections of skin, hair, and nails that extend deeper into the epidermis and may evoke host immune responses that result in pathologic changes in the deeper layers of the skin. Common cutaneous mycoses are tinea corporis (ringworm of the body), tinea unguium or onychomycosis (fungal infection of the fingernails, toenails, and the nail bed; Figure 3), tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea capitis (fungal infection of the scalp and hair) [87]. These conditions are rather common and are mostly caused by parasitic dermatophytes in the genus Trichophyton, in addition to the genera Epidermophyton and Microsporum [87]. Other widespread cutaneous fungal infections are oropharyngeal candidiasis (oral thrush) and vulvovaginal candidiasis, common fungal infection of the mouth and vagina caused by the opportunistic pathogenic yeast Candida albicans [88, 89]. A less frequent but distinctive fungal skin infection that is prevalent in tropical regions is caused by the yeast-like fungus Lacazia loboi, which is transmitted by direct contact with contaminated water, soil, vegetation, or an infected dolphin, and usually presents with bumps in the skin, firm swellings, deep skin lesions, or even malignant tumors [90].
Figure 3.
Tinea unguium or onychomycosis mostly caused by dermatophytes in the genus Trichophyton (from: https://upload.wikimedia.org/wikipedia/commons/5/57/Onychomycosis.JPG).
Subcutaneous mycoses are chronic, localized fungal infections of the dermis, subcutaneous tissues, muscle, and fascia. These lesions are caused by a variety of soil saprophytes following trauma to the skin which allows the fungi to enter the body. Common subcutaneous mycoses are sporotrichosis (rose gardener’s disease) caused by Sporothrix schenkii in soil and decomposing plant material [91], and intertriginous candidiasis, an opportunistic infection of the skin characterized by dermatitis, localized rashes, and/or yellowing of the nails caused by yeasts in the genus Candida [92]. Subcutaneous fungal infections are in general difficult to treat and may require surgical interventions such as debridement [20].
Systemic infections can be caused by primary pathogens or opportunistic pathogens. As mentioned above, systemic mycoses due to primary pathogens can occur in people with a normal immune system [20, 21]. They generally originate in the lungs, tend to develop at a slow rate, and may spread to the brain, heart, lungs, liver, spleen, and/or kidneys [20, 21]. Fungi that cause systemic mycoses are often dimorphic, inherently virulent, and can cause serious health problems. Examples of primary fungal infections are paracoccidioidomycosis (characterized by asymptomatic lung infection preceding in 5% of cases acute or subacute forms in children and young adults, and the chronic form in adults), coccidioidomycosis, and histoplasmosis, caused by soil fungi in the genera Paracoccidioides [93], Coccidioides [94], and Histoplasma capsulatum [95], respectively. These conditions primarily affect the respiratory organs, may remain asymptomatic, but may cause acute, subacute, or chronic infections [20, 21].
Systemic mycoses due to opportunistic pathogens are infections of patients with immunocompromising conditions who would otherwise not be infected [20, 21, 96]. Patients with a high risk of developing such invasive fungal infections are those suffering from HIV/AIDS, those with an altered flora caused by antibiotics, those suffering from diabetes mellitus, those undergoing chemotherapy for metastatic cancer or organ transplantation, and those undergoing major surgical procedures [20, 21, 96]. Common opportunistic mycoses are candidiasis, cryptococcosis, and aspergillosis [20, 21, 96]. Candidiasis is caused by species in the genus Candida (particularly Candida albicans) which normally live on the skin as well as in the mouth, throat, gut, and vagina, without causing any problems in healthy individuals [88, 89]. Cryptococcosis is a pulmonary or disseminated infection acquired by inhalation of soil or dried bird’s feaces (particularly pigeon’s) contaminated with the encapsulated yeasts Cryptococcus neoformans or Cryptococcus gattii [97]. And aspergillosis is caused by species in the ubiquitous genus of Aspergillus and also affects the respiratory system [98]. These fungal infections are in general rather aggressive, often rapidly spread to other organs, and can be life-threatening, while early diagnosis and efficacious treatment are in general difficult [20, 21, 96].
3.2 Epidemiology
Despite the astonishing number of fungal species, only some 300 are known to cause illness in humans. Nevertheless, the number of individuals on Earth having a fungal infection is astonishing [99]. Fortunately, many cases are aymptomatic to mild mucocutaneous infections rather than potentially life-threatening systemic infections [99]. Even so, nearly a billion people on our planet have skin, nail and hair fungal infections; tens of millions suffer from mucosal candidiasis; and more than 150 million fall victim to debilitating and potentially serious fungal diseases [99, 100, 101, 102].
Among the latter conditions are roughly 3,000,000 cases of chronic pulmonary aspergillosis, about 223,100 cases of cryptococcal meningitis complicating HIV/AIDs, about 700,000 cases of invasive candidiasis, about 500,000 cases of pneumocystis pneumonia, about 250,000 cases of invasive aspergillosis, about 100,000 cases of disseminated histoplasmosis, over 10,000,000 cases of fungal asthma, and about 1,000,000 cases of fungal keratitis per year [99, 100, 101, 102]. Notably, over 1.6 million people die each year from their disease, which is comparable to the mortality due to tuberculosis and more than three-fold that caused by malaria [99]. These disturbingly high numbers are important causes of the emergence of the HIV/AIDS pandemic as well as the increasing incidence of chronic obstructive pulmonary disease and cancers, conditions that promote the virulence of opportunistic and potentially pathogenic fungi [103, 104, 105].
3.3 Treatment
The five main classes of drugs for treating fungal infections are polyenes, azoles, allylamines, echinocandins, and the antimetabolite flucytosine [22, 23]. Polyene antimycotics are macrolides derived from certain species of Streptomyces bacteria. These compounds bind to ergosterol in the fungal plasma membrane, perturbing membrane integrity and causing leakage of K+ and Na+ ions [106]. Well-known examples are nystatin from Streptomyces noursei, amphotericin B from Streptomyces nodosus, and natamycin from Streptomyces natalensis [106]. Nystatin is mainly used for the topical, oral, or intravaginal treatment of Candida infections including diaper rash, oral thrush, esophageal candidiasis, and vaginal yeast infections [106]. Amphotericin B is parenterally given against a broad range of invasive fungal infections such as aspergillosis, candidiasis, coccidioidomycosis, and cryptococcosis [106]. Natamycin is mainly used topically as cream and in eye drops for treating fungal infections of the eyelids, conjunctiva, and cornea [106].
Antifungal azoles are synthetic five-membered heterocyclic compounds that can be distinguished into imidazoles and triazoles. Imidazoles have two atoms of nitrogen in the azole ring, triazoles have three. The primary mechanism of action of these compounds is inhibition of lanosterol 14-α-demethylase, an enzyme required for the biosynthesis of ergosterol [107]. Imidazoles such as miconazole, ketoconazole, and clotrimazole are topically used for treating fungal infections of the skin and mucous membranes such as ringworm, pityriasis versicolor, vaginal yeast infections, oral thrush, dandruff, and diaper rash [107]. ‘First-generation’ triazoles such as fluconazole and itraconazole can be given both orally and intravenously against a range of superficial infections, but also against invasive fungal infections such as candidiasis, coccidiodomycosis, cryptococcosis, histoplasmosis, dermatophytosis, aspergillosus, and/or pityriasis versicolor [107]. ‘Second-generation’ triazoles such as voriconazole, posaconazole and ravuconazole have broad-spectrum activity against yeasts and molds including Aspergillus species, and are more potent and more active against resistant fungi when compared to their first-generation counterparts [107].
Allylamine antifungal compounds inhibit squalene epoxidase (one of the rate-limiting enzymes in sterol biosynthesis), resulting in the intracellular accumulation of toxic concentrations of squalene, depletion of ergosterol, and fungal cell death [108]. The two most important representatives of this class of antifungal compounds are naftifine and terbinafine. Naftifine is mainly used for the topical treatment of athlete’s foot, jock itch, and ringworm [108]. Terbinafine, either taken by mouth or applied to the skin as a cream or ointment, is used to treat pityriasis versicolor, ringworm including jock itch and athlete\'s foot, as well as fungal nail infections [108]. Of note, terbinafine is the treatment of choice for fungal infection of the nails but is only efficacious in this condition when taken as oral tablets, not when used as a topical cream or ointment [108].
A more recent class of antifungal drugs is that of the semisynthetic echinocandin derivatives caspofungin, micafungin, and anidulafungin [109]. These compounds act by inhibiting the synthesis of β-glucan in the fungal cell wall, preventing cross-linking of the cell wall components, perturbing the integrity of the cell wall [109]. Because of this mechanism of action, toxicity associated with echinocandins is infrequent (glucan is not found in mammalian cells) [109]. Furthermore, they are not metabolized by cytochrome P450 enzymes, which virtually excludes drug-drug interactions [109]. Echinocandins are administered intravenously, and are effective for treating (drug-resistant) mucosal and systemic Candida and Aspergillus infections [109].
The fluorinated cytosine analog 5-fluorocytosine or flucytosine is an antimetabolite that, following penetration through the fungal cell via cytosine permease, is intracellularly converted into 5-fluorouracil that perturbs DNA and RNA synthesis, resulting in the death of the fungus [110]. It was initially developed as an antineoplastic agent, but is now indicated in combination with amphotericin B for the treatment of septicemia, endocarditis and urinary system infections caused by Candida spp., as well as meningitis and pulmonary infections due to Cryptococcus spp. [110]. It can be used singly or with other antifungals for chromomycosis [109] and can be given orally or intravenously [110]. Chromomycosis (also known as chromoblastomycosis) is a chronic fungal infection that mainly occurs in subtropical and tropical areas and that is caused by traumatic inoculation of pigmented fungi (generally the ascomycetous soil saprotroph Fonsecaea pedrosoi) and is characterized by slow-growing, raised, crusted small nodular to papillary-like lesions of the skin and subcutaneous tissues [111].
4. Suriname: the country profile, health and health care, and fungal infections
Suriname is a presidential republic located on the northeast coast of South America, bordering the Atlantic Ocean to the north, French Guiana to the east, Brazil to the south, and Guyana to the west (Figure 4). Although, situated in South America, Suriname is considered a Caribbean country rather than a Latin American country [112]. The climate is tropical moderated by trade winds, with dry and rainy seasons [113]. The average daily temperature throughout the year varies between 21 and 32°C (70–90°F), the average annual percentage of humidity is 72.0%, and the yearly rain average is 2200 mm [113]. The capital city Paramaribo lies roughly 15 km from the Atlantic Ocean along the Suriname River. Paramaribo’s historical center has been designated a World Heritage status by the United Nations Educational, Scientific, and Cultural Organization (UNESCO) in 2002 [114].
Figure 4.
Map of Suriname (from: https://images.app.goo.gl/nEEqreFZcJy1XHJz8). Insert: location of Suriname in South America (from: https://images.app.goo.gl/75w3iEDBm44i3W259).
The country’s land area of about 165,000 km2 is divided into ten administrative districts [113, 115], and can be distinguished into northern urban-coastal and rural-coastal plains consisting of sandbanks and mudbanks as well as swampland, and a southern rural interior with mostly savanna grassland, rolling hills that rise to over 1000 m [113, 115], and dense, pristine, tropical rain forest with a great diversity of flora and fauna [116]. The relatively narrow urban-coastal area—that includes Paramaribo and its suburbs—harbors approximately 80% of the population of over 600,000 [113, 115]. The hinterland encompasses more than three-quarters of Suriname’s land surface and is home to the remaining 20% of Suriname’s inhabitants [113, 115]. The urban areas are characterized by a “western” lifestyle, modern health-care facilities, and an economy that is mainly based on commerce, services, and industry [113]. The rural societies have a more traditional way of living, lack comprehensive public health services, and have agriculture, forestry, crude oil drilling, bauxite and gold mining, as well as ecotourism as major economic activities [113].
The official language of government, business, media, and education is Dutch, reminiscent of the nearly 300 years Suriname was a colony under Dutch rule [117]. The common language is Surinamese or Sranantongo has evolved from an English- and Portuguese-based lingua franca in the seventeenth century to a language with its own official orthography [117]. Suriname’s economy is dominated by the mining industry, with oil and gold accounting for approximately 85% of exports and 27% of government revenues [118]. Other means of sustenance are agriculture, fisheries, forestry, and ecotourism [118]. These activities have led to a gross domestic product (GDP) in 2019 of USD 4221 billion and an average gross national income per capita in that year of USD 6340 [118, 119]. This positions Suriname on the World Bank’s list of upper-middle-income economies [119].
Suriname’s population is among the most varied in the world, comprising the Indigenous Amerindians, the original inhabitants; descendants from enslaved Africans imported between the seventeenth and the nineteenth century (called Maroons and Creoles); descendants from indentured workers from China, India (called Hindustanis), and the island of Java, Indonesia (called Javanese) who had been attracted between the second half of the nineteenth century and the first half of the twentieth century; descendants from settlers from several European and Middle Eastern countries; and more recently, immigrants from various Latin American and Caribbean countries including Brazil, Guyana, French Guiana, Haiti, and Cuba [115, 120, 121]. According to the 2012-census, the largest groups are represented by the Hindustanis, Maroons, Creoles, and Javanese, making up roughly 27, 22, 17, and 16%, respectively, of the total Surinamese population [115, 122].
4.1 Health and health care in Suriname
Like most other South American and Caribbean countries [123], Suriname can be characterized as a demographically transitioning country with declining mortality and infertility rates as well as a growing and aging population [124, 125]. These changes are for an important part attributable to considerable progress in health care, nutrition, sanitation, and drinking water quality; the eradication of various infectious diseases including malaria; as well as improvements in average living and working conditions, education, and income [124, 125]. The result was a decline of the death rate from 24 per 1000 in 1923 to 8 per 1000 in 2017 and the attainment of an average life expectancy of 72 years in 2019 [126]. The latter estimate is slightly below those for the rest of South America [126].
On the other hand, as also seen in many demographically transitioning countries [123], during the past decades, non-communicable diseases (NCDs) have largely replaced infectious diseases as the most important causes of morbidity and mortality in Suriname [127, 128]. According to estimates of the World Health Organization, cardiovascular ailments, cancer, and diabetes mellitus, along with their complications, were among the leading causes of morbidity and mortality in Suriname in 2014 [127]. Notably, 68% of the total number of deaths in the country in that year were attributable to these NCDs [127], and the probability of dying from these conditions between age 30 and 70 years was estimated at 14% [127]. These NCDs were also among the main causes of mortality in 2012–2013, accounting for almost 1000 cases or about one-third of the total number of 3260 deaths in that period [127, 128]. Nevertheless, Suriname is not entirely free from infectious diseases, important ones being bacterial and protozoal diarrhea, hepatitis A, and typhoid fever; vector-borne diseases such as dengue fever and chikungunya; and more recently, HIV/AIDS and covid-19 [129, 130]. The fungal infections in Suriname are addressed further in this section.
The responsibility of all aspects of health care in Suriname is in the hands of the Minister of Health and the Director of Health (the Chief Medical Officer) [131]. About 6% of the country’s GDP is available for this purpose [119]. This sum covers, among others, the health costs for the economically weakest individuals, insurance for government employees and employees of government-related companies, as well as import and distribution of essential pharmaceuticals [131]. Specialized institutions under the responsibility of the Ministry of Health are the Regional Health Services and the Medical Mission [131]. The Regional Health Services run about forty community health centers in Suriname’s coastal area and are, together with approximately 250 general practitioners, responsible for primary care in that part of Suriname [131]. The Medical Mission is a non-governmental organization that provides health services to people in the country’s hinterland through a network of almost fifty clinics spread over the interior [131].
These institutions are supported by the Dermatology Services, the Office of Public Health, and Stichting Lobi Health Center [19]. The Dermatology Services is a governmental institution that specifically deals with dermatological diseases, sexually transmitted diseases, and HIV/AIDS [131]. The Office of Public Health is also government-owned and is principally involved in programs to prevent and fight parasitic and microbial diseases [131]. Stichting Lobi Health Center is a non-governmental organization for Sexual and Reproductive Health Services [131]. Secondary care is provided by two private and two government-supported hospitals in Paramaribo and one public hospital in the western district of Nickerie [131]. All hospitals have modern clinical laboratory facilities at their disposal including a microbial culture laboratory at the Academic Hospital Paramaribo [131]. There are, in addition, four private clinical laboratories and three private radiology clinics in Suriname [131]. The Academic Hospital Paramaribo also functions as a training facility for both general practitioners and medical specialists, and provides tertiary care at, among others, a Thorax Center, a Neurology High-Care Unit, and a Neonatal Care Unit [131].
4.2 Fungal infections in Suriname
Until now, there is no registry of fungal and other infections in Suriname, and only a relative handful of scientific papers have addressed these topics. As a result, there are no accurate data available about either the prevalence and incidence of, and mortality due to mycoses in the country. Still, according to several general practitioners, dermatologists, gynecologists, infectologists, and epidemiologists, rather prevalent mycoses in Suriname are infections of the skin and mucous membranes caused by Malassezia spp., those due to Candida spp., as well as tineas caused by dermatophytic fungi in the genera Trichophyton, Epidermophyton, and Microsporum. These infections mainly include pityriasis versicolor (called ‘lota’ in Suriname); infections of the mouth, throat, gut, and vagina; ringworm; infections of fingernails, toenails, and nail bed; athlete’s foot; jock itch; as well as infections of scalp and hair [132, 133], and are treated according to the standard medical protocols addressed in the previous section of this monograph [134, 135].
In addition, a relatively recent overview of infectious diseases of Suriname [136] has mentioned the occurrence in the country of chromomycosis, cryptococcosis, dermatophytosis, histoplasmosis, lobomycosis, as well as invasive fungal infections. As mentioned before, chromomycosis or chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues that is caused by traumatic inoculation of pigmented fungi (often Fonsecaea pedrosoi) [111]; cryptococcosis is a pulmonary or disseminated infection acquired by inhalation of soil or dried pigeon feces contaminated with the encapsulated yeasts Cryptococcus neoformans or Cryptococcus gattii [97]; dermatophytoses are tineas that affect hair, skin, or nails and are most commonly caused by the dermatophytic mold Trichophyton genus [87]; histoplasmosis is caused by inhaling spores of the dimorphic fungus Histoplasma capsulatum that is often found in bird and bat droppings [95]; and lobomycosis is a skin infection that is caused by the yeast-like fungus Lacazia loboi and is transmitted by direct contact with contaminated water, soil, vegetation, or an infected dolphin [90].
Invasive fungal infections reported in Suriname are those involving major syndromes such as candidiasis, blastomycosis, and histoplasmosis [136]. These conditions are often life-threatening and are in general seen in critically ill, aged patients as well as immunosuppressed individuals such as those suffering from AIDS and recipients of transplanted abdominal organs [137]. Invasive candidiasis occurs when endogenous Candida organisms that are normally found in the digestive tract, enter the bloodstream, spread through the body, and damage the heart, brain, eyes, bones, and other parts of the body [138]. Blastomycosis is mainly caused by the thermally dimorphic fungi Blastomyces dermatitidis and Blastomyces gilchristii which cause pneumonia and disseminated disease following inhalation of mycelial fragments and spores [139]. Disseminated histoplasmosis occurs—as indicated in the preceding alinea—after inhaling the spores of Histoplasma capsulatum from droppings of birds and bats, and develops progressively, spreading from the lungs to other organs through the bloodstream, and affecting multiple organs [140]. This syndrome is not uncommon in Suriname, where it has particularly been associated with immunocompromised patients suffering from HIV/AIDS [141]. These infections are also treated as mentioned before in this monograph. Incidentally, an assessment of six families and fifteen genera by the Zoological Collection of Suriname suggested that the amphibian skin disease chytridiomycosis, caused by the pathogenetic fungus Batrachochytrium dendrobatidis, is not present in the country [142].
5. Traditional herbal treatments of fungal infections in Suriname
Despite the availability of affordable and accessible health care [131], traditional medicines are abundantly used in Suriname [143]. The various ethnic groups of Suriname have largely preserved their beliefs, values, behaviors, language, religion, ancestry, and other characteristics, including much of their specific ethnopharmacological traditions [120, 131]. This probably was a means of strengthening the ethnic identity during the secluded lifestyle the former colonial authorities had forced them into [120, 131]. As a result, the use of various forms of traditional medicine is deeply rooted in the entire Surinamese population [143]. Consequently, many diseases are often treated with traditional plant-based medicines instead of, or together with prescription drugs [143]. This also holds for several fungal infections, particularly the relatively mild superficial and cutaneous mycoses.
All ethnic groups in Suriname have made important contributions to the traditional treatment of mycoses. The Indigenous Trio Amerindians recognize various skin infections including those from the fungal origin, and have identified medicinal plants for treating these conditions [144]. Maroon and Creole females regularly use genital steam baths for their personal hygiene [145], but presumably also to prevent and treat vaginal candidiasis [145]. Chinese traditional healers have prescribed curcumin, the yellow-colored secondary metabolite in the turmeric Curcuma longa L. (Zingiberaceae), for centuries against fungal infections [146]. Practitioners of Indian Ayurveda, Unani, and Siddha are for over two millennia familiar with the antifungal properties of the neem tree Azadirachta indica A. Juss., 1830 (Meliaceae) [147]. And Javanese Jamu has recognized centuries ago the apparent efficacy of the rhizomes from the blue ginger Alpinia galanga (L.) Willd. (Zingiberaceae) against pityriasis versicolor [148].
The next sections address nine plants that have less thoroughly been evaluated in the scientific literature but are commonly used in Suriname for treating fungal infections. The plants have been selected from several comprehensive publications describing various aspects of medicinal plants in the country [148, 149, 150, 151, 152, 153, 154, 155]. Their relevant aspects have been summarized in Table 1. Hereunder, the plants have in detail been assessed for their phytochemical and pharmacological properties, to support their traditional use against fungal infections.
Plant family
Plant species (vernacular name in English; Surinamese)
Plants with antifungal activity addressed in this section, parts preferentially used, presumed antifungal constituents, and proven antifungal activity.
References are placed between [ ].
5.1 Araceae—Colocasia esculenta (L.) Schott
The taro Colocasia esculenta (L.) Schott. is believed to originate from south-eastern Asia (hence its Surinamese vernacular name ‘snesi taya’ meaning ‘Chinese taro’), but is now grown in many tropical regions including Suriname for its edible, starchy corm. The plant bears characteristic large green leaves which resemble elephant ears (Figure 5) and have long, erect petioles of 40–200 cm tall growing in clusters from a large, tuberous rootstock. C. esculenta is presumably one of the earliest plants human beings have started to cultivate and has become one the most extensively grown members of the plant family Araceae. Similarly to yam, C. esculenta corm is an important food staple in many African, Oceanic, and South Asian cultures. The corm can be roasted, baked, or boiled, and is also used for baby food. Furthermore, the nutritious young leaves and stems are eaten after the pungent flavor and the stinging and burning calcium oxalate- or calcium carbonate-containing raphides [234] have been removed by boiling twice or by steeping overnight in cold water.
Figure 5.
The taro Colocasia esculenta (L.) Schott. (Araceae) (from: https://images.app.goo.gl/HH8Zt3mnRgyfVqhSA).
C. esculenta corm, leaf, leaf sap, and stem are traditionally used for treating a variety of conditions such as parasitic infections; asthma; diabetes mellitus; hypertension; neurological disorders; arthritis and other inflammatory disorders; body ache; amenorrhea; stomach problems and liver ailments; internal haemorrhages; cysts, boils, and wounds; baldness; as well as bacterial infections including conjunctivitis [235, 236]. In Suriname, a raw peeled corm is eaten with salt against jaundice [153]; the grated whole plant is made into an ointment for treating skin conditions including acute dermatitis that may be caused by Malassezia yeasts [237]; the stem is rubbed between the toes to treat fungal infections such as tinea pedis after the raphides have been broken down by heating [148]; and the corm is used as an ingredient of genital steam baths to recuperate the uterus post-partum and treat vulvovaginal candidiasis [155].
The results from several pharmacological studies provided support for some of these traditional uses. Aqueous and ethanolic leaf extracts decreased blood glucose levels in alloxan-induced diabetic rats to a comparable degree as the oral hypoglycemic medication metformin [238]. Cooked corm decreased tissue cholesterol and triglycerides in cholesterol-fed rats [239]. Ethanolic leaf extracts exerted anti-inflammatory activity, inhibiting carrageenan-induced hind paw edema, carrageenan-induced pleurisy, and cotton pellet-induced granuloma in Wistar rats [240]. Ethanolic corm extracts elicited hepatoprotective effects in paracetamol- and carbon tetrachloride-treated laboratory rats [241] while ethanolic leaf extracts had similar effects in precision-cut liver slices from rats [242]. And aqueous and ethanolic leaf extracts showed anthelmintic activity against earthworms [243].
Several studies also reported antimicrobial activity of C. esculenta including antifungal activity. For instance, an aqueous extract of the leaves displayed remarkable in vitro activity against various bacterial strains as well as the common food contaminant Aspergillus niger and the opportunistic pathogenic gastrointestinal yeast Candida albicans when compared to the reference compounds chloramphenicol and rifampicine [156]. Incidentally, a chloroform extract of C. esculenta leaf also showed antibacterial activity in an evaluation of fifteen coastal medicinal plants for antibacterial activity against bacterial fish pathogens [244]. Furthermore, comparing 130 ethanol extracts of lyophilized vegetables for inhibitory activity on recombinant human lanosterol synthase activity in a cell-free assay, a C. esculenta corm preparation showed the highest activity [245]. This is of relevance when considering the key role of lanosterol synthase in the viability of fungi [246].
A wide range of chemical compounds including flavonoids, β-sitosterol, and steroids have been isolated from C. esculenta [235, 236]. Still, there are no clear indications about the biochemical identity of the antifungal compound in this plant. However, in a study with the phytopathogenic crust fungus Athelia rolfsii—the causative agent of southern blight in many crops including tomato, onion, snapbean, and pea—the antifungal activity could be related to a phytocystatin in the corm that potently inhibited cysteine protease [157]. The phytocystatin inhibited mycelium growth and lyzed sclerotia by acting against the endogenous cysteine proteinase in the mycelia [157]. Notably, the inhibition of exogenous proteinases by phytocystatins have been suggested to represent a defense mechanism of plants against, among others, pathogenic fungi [247].
5.2 Euphorbiaceae—Euphorbia hirta L
The milkweed Euphorbia hirta L. (Figure 6) is a pantropical weed that is presumably native to India but is now encountered in many tropical parts of the world in gardens, abandoned estates, open grasslands, and along roadsides. It can grow up to 60 cm tall and has a solid, hairy stem. The vernacular name ‘milkweed’ stems from the white latex the stem produces when damaged, a characteristic shared by most plants in the genus Euphorbia [248]. This distinctive feature is also reflected by the Surinamese vernacular name ‘sabana merkiwiwiri’ that means ‘the herb from the savanna that emits a milky substance’. The latex is believed to represent a deterrent to herbivores, is rather toxic, and is used as an ingredient of arrow poisons and antimicrobial substances [249].
Figure 6.
The milkweed Euphorbia hirta L. (Euphorbiaceae) (from: https://images.app.goo.gl/1HjVzdfUghX9AyiH7).
E. hirta has also been named ‘asthma-plant’ because of the traditional use of preparations from the leaf against asthma, bronchitis, and hay fever [250]. Preparations from various parts of the plant are, furthermore, traditionally used for treating, among others, gastrointestinal disorders; worm infestations; hypertension; genito-urinary conditions including kidney stones; diabetes mellitus; lactation insufficiency; conjunctivitis; several skin diseases as well as swellings and boils; and as a gargle for oral thrush [155, 251, 252]. In Suriname, E. hirta is used, in addition, as an essential ingredient of vaginal steam baths, in herbal baths to make child delivery proceed smoothly, and as an ingredient of cleansing baths to protect against evil forces [155].
Pharmacological studies with various laboratory models supported the traditional claims of E. hirta preparations against asthma [251], diarrhea [253], bowel cramps [254], hypertension [255], and diabetes mellitus [256], and as a diuretic [257]. There was also preclinical evidence for sedative and anxiolytic activity [258]; analgesic, antipyretic, and anti-inflammatory effects [259, 260]; as well as antiamoebic [254] and antimalarial actions [261, 262]. Several of these effects have been associated with the presence in the plant of polyphenolic compounds such as quercitin [253, 254, 263, 264]. In addition, preparations from several of its parts exhibited meaningful and broad antibacterial activity in laboratory assays (see, for instance, references [158, 164, 165] including some activity against Helicobacter pylori [265].
There is also ample evidence for antifungal activity of E. hirta. For instance, aqueous extracts from the leaf inhibited aflatoxin contamination of rice, wheat, maize, and mustard crops by the cosmopolitan saprotrophic and pathogenic fungus Aspergillus flavus [159] and the growth of Saccharomyces cerevisiae in culture [164]. Ethanolic leaf extracts displayed meaningful activity against the plant pathogenic molds Colletotrichum capsici, Fusarium pallidoroseum, Lasiodiplodia theobromae, and Phomopsis caricae-papayae [160] as well as Aspergillus fumigatus, Aspergillus niger, Aspergillus flavus, and Rhizopus oryzae [161]. Importantly, some combinations of a methanol extract of the leaf and nystatin exhibited synergistic activity against clinical isolates of Candida albicans [266].
A preparation from the whole plant also inhibited aflatoxin production by Aspergillus flavus [162], while methanolic and acetonic extracts from the whole plant and the latex from the stem showed meaningful activity against Aspergillus flavus; Fusarium incarnatum that affects crops such as sorghum, rice, and maize; as well as Trichophyton spp., the causative agents of athlete\'s foot, ringworm, jock itch, and similar infections of nail, beard, skin and scalp [158]. Furthermore, ethanolic extracts of the aerial parts of the plant were active against Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, and Rhizopus oryzae [163]; methanolic extracts of leaf, flower, stem, and root were active against Candida albicans [166]; and water extracts of the root and shoots were active against a clinical isolate of Candida albicans, although not against Penicillium spp., Aspergillus spp., and Microsporum spp. [165].
So far, only a few studies have assessed the ingredient(s) and/or the mechanism(s) involved in the antifungal activity of E. hirta preparations. For instance, the antimicrobial activity of the crude plant extract has been attributed to tannins, flavonoids, alkaloids, glycosides, proteins, sterols, and/or saponins [163]. Nevertheless, these observations support the use of E. hirta in traditional medicine against certain fungal infections, providing a possible explanation for the use of a decoction of fresh leaves as a treatment for oral thrush [251] and in genital steam baths for cleansing the vagina from, among others, fungal infections [155].
5.3 Lamiaceae—Ocimum tenuiflorum L
Ocimum tenuiflorum L. (Figure 7), commonly known as holy basil or tulsi in Surinamese-Hindi or Sarnami, is a perennial plant growing between 30 and 100 cm tall that is particularly valued for its strong-scented and sharp-tasting but edible leaves. It is native to India but has spread throughout the south-eastern parts of Asia as a cultivated plant, and is also grown in various other tropical parts of the world with an Indian diaspora such as Suriname. As indicated by the vernacular ‘holy basil’, it is a sacred plant in Hinduism and is widely grown around Hindu houses and temples for its perceived protective influence [267]. Leaf preparations are regarded as ‘elixirs of life’ and believed to promote longevity [267], and the flowers are used as a holy cleanser for food offerings during prayers.
Figure 7.
The holy basil Ocimum tenuiflorum L. (Lamiaceae) (from: https://images.app.goo.gl/F1HdJrRmdGUcjxZM6).
O. tenuiflorum leaf essential oil and seed extracts contain antimicrobial, insecticidal, and antifeedant compounds and have for centuries been added to stored grains to repel insects [268]. The seeds also yield an essential oil containing pleasantly scented monoterpes, sesquiterpenes, and phenols which are used in the cosmetic industry and food technology [269]. In addition, preparations from all parts of the plant have a myriad of traditional medical applications. A few indications are asthma and bronchitis; fevers, colds, influenza, sinusitis, and headaches; inflammatory conditions such as rheumatism and arthritis; pains, cramps, and spasms; diabetes mellitus; hypertension; convulsions; stress and a disturbed homeostasis; parasitic infections such as leishmaniasis; as well as antibacterial and antifungal infections such as ringworm [153, 155, 270]. Some of these activities have been attributed to eugenol, the major compound in the essential oil, as well as other terpenoids such as β-elemene, β-caryophyllene, and germacrene [271, 272].
Several pharmacological investigations supported some of the traditional claims for O. tenuiflorum. For instance, in line with its presumed usefulness against asthma and related conditions, a leaf extract displayed anti-anaphylactic, antihistaminic, and mast cell-stabilizing activities in laboratory rodents [273]. Indications for its anti-inflammatory, analgesic, and antipyretic activities came from the inhibitory effects in laboratory animals of the non-volatile oil from leaf and seed on formaldehyde-, carrageenan-, inflammatory mediators-, or turpentine oil-induced arthritis, paw edema, and joint edema [274, 275, 276]; acetic acid-induced tail flicking, tail clipping, tail immersion, and writhing [277]; and typhoid-paratyphoid A/B vaccine-provoked pyrexia [277].
Furthermore, oral administration of an ethanolic leaf extract led to marked lowering of blood sugar in animal and laboratory models of diabetes mellitus [278, 279], and the O. temuiflorum-containing polyherbal Ayurvedan supplement Diabecon® seemed efficacious and safe in helping control blood sugar levels in diabetics [280]. In addition, ethanol and chloroform leaf and stem extracts protected rats to a comparable extent as phenytoin from tonic convulsions induced by transcorneal electroshock [281]. And ethanolic leaf extracts led to normalization of stress hormone and neurotransmitter levels in animals which had been exposed to noise stress [282, 283].
As well, both the essential oil from O. tenuiflorum leaf and purified eugenol showed potent anthelmentic activity against Caenorhabditis elegans [284]. Aqueous extracts, several organic extracts, and the essential oil of the leaf and the root of the plant also exerted meaningful antibacterial activity in vitro against a broad range of bacterial strains (see, for instance, references [167, 285]. O. tenuiflorum preparations were also active against isolates of various bacterial strains from urine, stool, and sputum from infected individuals [286], and attacked both Gram-positive and Gram-negative pathogenic bacteria [287] as well as methicillin-resistant Staphylococcus aureus [288].
There are also several studies reporting antifungal activity of O. temuiflorum. Aqueous leaf extracts and the leaf essential oil were active against cultures of Candida albicans and Candida tropicalis [170] as well as those of Aspergillus flavus [168]. The fractions obtained after successive extraction of the crushed and dried leaf with hexane, benzene, chloroform, ethyl acetate, methanol, and water were active against five different clinical isolates of dermatophytic fungi, namely Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Microsporum gypseum, and Epidermophyton floccosum [171]. Hexane, acetone, and ethanol extracts of leaf and root were active against the plant pathogenic fungal strains Alternaria alternata, Fusarium oxysorum, Cochliobolus lunatus, and Rhizoctonia solani, as well as Aspergillus flavus and Candida albicans [169]. And a methanol leaf extract was active against cultures of the fungal species Alternaria porri; Aspergillus flavus, Aspergillus niger, and Aspergillus oryzae; as well as Penicillium chrysogenum [167]. Some investigators attributed the antifungal activity of the essential oil to eugenol [168], but others to linalool [170]. Markedly, both the leaf essential oil and eugenol not only inhibited the growth of Aspergillus flavus but also completely inhibited aflatoxin B1 production by the fungus [168].
5.4 Lauraceae—Persea americana Mill
The avocado Persea americana Mill. is a large, spreading, evergreen tree that can reach a height of approximately 30 m and bears large fruits (Figure 8) that are surrounded by a leathery peel and contain a single large seed. The plant presumably originates from south-central Mexico but is now cultivated in various tropical and subtropical areas for the commercially valuable and very nutritious fruit [289]. The dried or fresh leaves are prepared as a tea but also used as a spice in stews, giving a flavor that resembles that of anise.
Figure 8.
The avocado Persea americana Mill. (Lauraceae) (from: https://images.app.goo.gl/LoRCDzk7Z8bW61A28).
The fresh fruit pulp is massaged into the hair and scalp as a vitamin-rich hair tonic and restorer, and the cosmetic industry uses the fruit oil as an ingredient of soaps and skin moisturizer products [290]. Avocado oil has a favorable lipid composition and is very suitable for cooking due to its high smoke point [290, 291], but is relatively expensive when compared to common salad and cooking oils. Leaf and seed contain cyanide and the fatty acid fungicidal compound persin in amounts that can cause intoxications in small animals but at too low concentrations to be hazardous to humans [292]. However, more recent studies showed that methanolic extracts of fruit and leaf caused chromosomal aberrations in cultured human peripheral lymphocytes [293].
Almost all parts of P. americana are medicinally used in many traditional systems including those in Suriname. Conditions treated with preparations from this plant are, among others, dysentery, gut parasites, gastritis, gastroduodenal ulcers, and diarrhea; liver and bilious disorders; anemia; hypertension and hypercholesterolemia; coughing; menstrual problems; cystitis; exhaustion; nervousness; to evoke abortion; against scabies, purulent wounds, lesions of the scalp, dandruff, and hair loss; as well as various microbial infections [149, 152, 153, 155, 289]. Some of these applications may be related to the presence in the plant of certain aliphatic acetogenins such as persin, avocadenols, 1,2,4-trihydroxyheptadec-16-ene, and 1,2,4-trihydroxynonadecane; terpenoid glycosides such as glycosylated abscisic acid derivatives; furan ring-containing derivatives called ‘avocadofurans’; flavonoids such as quercetin, catechin, and epicatechin; as well as the plant coumarin scopoletin [294].
The results from pharmacological studies support some of the ethnomedical uses of P. americana. Aqueous leaf and seed extracts displayed vasorelaxant and blood pressure-lowering activities in laboratory rats and isolated rat aortic rings precontracted with KCl or norepinephrine [295, 296, 297]. Aqueous and/or methanolic leaf and/or seed extracts reduced plasma glucose levels in alloxan-treated rats [298, 299] and influenced lipid metabolism in normal or hypercholesterolemic rats [297, 298, 300]. The fruit extract exerted hepatoprotective effects in rats which might be attributed to certain constituents in the oil such as the fatty acid acids [301]. A methanol leaf extract also exerted hepatoprotective activity in rats [302], while aqueous leaf extracts showed analgesic and anti-inflammatory [303] as well as anticonvulsant effects in laboratory mice [304].
Furthermore, chloroformic and ethanolic extracts of the seed were active against Giardia lamblia and Entamoeba histolytica, the causative agents of giardiasis and amoebic dysentery, respectively [305]. Seed preparations also showed in vitro activity against the trophozoites of Trichomonas vaginalis (that is responsible for trichomoniasis) [305], the epimastigotes of Trypanosoma cruzi (the etiological agent of Chagas’ disease) [306], and the larvae of Aedes aegypti (that spreads, among others, yellow fever, dengue fever, chikungunya, and Zika fever viruses) [172]. The antitrypanosomal activity was tentatively localized to 1,2,4-trihydroxyheptadecane and 1,2,4-trihydroxynonadecane derivatives [306].
Evidence for antibacterial activity of P. americana came, among others, from the in vitro activity of organic seed extracts against both Gram-positive and Gram-negative bacteria (except Escherichia coli) [307], and drug-sensitive as well as mono-resistant and multidrug resistant strains of Mycobacterium tuberculosis [305]; and that of a petroleum ether root extract against several bacterial strains including methicillin-resistant Staphylococcus aureus [175]. Some of the antibacterial effects might be due to the high phenolic content of the plant parts tested [173] and/or to avocadenols, 1,2,4-trihydroxyheptadec-16-ene, and 1,2,4-trihydroxynonadecane in the (unripe) fruit pulp [308].
There is also abundant evidence supporting that P. americana has antifungal activity. Hexane, chloroform, and methanol seed extracts displayed in vitro activity against yeast species including Cryptococcus neoformans [175, 176], Malassezia pachydermatis in dogs [177], and strains of Candida [172]. Ethanolic extracts from the epicarp and seed of several P. americana cultivars were active against the yeast Zygosaccharomyces bailii that is responsible for the spoilage of many normally shelf-stable acidic and/or high-sugar products such as fruit concentrates, wine, soft drinks, syrups, ketchup, mayonnaise, pickles, and salad dressings [178], but not against Penicillium spp. and Aspergillus flavus [307]. Seed extracts also showed in vitro activity against the black bread mold Rhizopus stolonifer as well as the plant pathogenic fungi Aspergillus flavus, Botryodiploidia theobromae, Fusarium oxysporum, and Geothricum candidum [179]. In addition, a hydroethanol leaf extract and ethyl acetate and butanol fractions derived therefrom, and an acetonic leaf extract showed substantial activity against both drug-sensitive and drug-resistant strains of Candida glabrata [173] and Candida albicans [174] as well as Aspergillus fumigatus, Aspergillus niger, and Aspergillus flavus [180].
The compounds responsible for the antifungal activities have not conclusively been identified. However, persin isolated from P. americana idioblast cells inhibited spore germination of Colletotrichum gloeosporioides that causes anthracnose and fruit rotting diseases in many economically important plants [181]. And 1-acetoxy-2,4-dihydroxy-n-heptadeca-16-ene and 1-acetoxy-2-hydroxy-4-oxo-heneicosa-12,15-diene in peel and flesh of unripe avocado fruits may act synergistically to prevent Colletotrichum gloeosporioides of infecting and causing bitter rot in P. americafruit and various other economically valuable crops [182, 183].
5.5 Lythraceae—Punica granatum L
The pomegranate Punica granatum L. is a slow-growing, deeply rooting, drought-tolerant, fruit-bearing deciduous shrub or small tree that grows to an average height of 5 meters, and is originally from the region extending from modern-day Iran to northern India. It is presumably one of the first fruit trees to be domesticated in the eastern Mediterranean region (around the fifth millennium BC), and is now cultivated in warm temperate to subtropical and tropical zones as an economically highly valued fruit crop (Figure 9). The inner, spongy mesocarp of the fruit houses around six hundred seeds, each surrounded by a juicy, deep red- or purple-colored sour-tasting pulp, the edible part of the fruit. The red color is attributable to anthocyanins such as delphinidin, cyanidin, and pelargonidin glycosides, the sour notes are from the acidic ellagitannins [229].
Figure 9.
The pomegranate Punica granatum L. (Lythraceae) (from: https://images.app.goo.gl/4bBBQ5FahGprBx4FA).
P. granatum has a history of traditional medical use that dates back more than 3000 years, and is still abundantly used today in various traditional medical systems. Indications are, among others, worm infestations, diarrhea and jaundice; throat infections, colds, fevers, cough, and a runny nose; nose bleeds; mouth sores and bleeding gums; tuberculosis and shortness of breath; hypertension; diabetes mellitus; syphilis; menstrual problems and vaginal discharge including leucorrhoea; and various other microbial and viral infections [149, 150, 152, 230, 231].
The results from phytochemical and pharmacological studies supported some of the traditional uses. For instance, leaf, stem bark, and peel extracts exerted both in vitro and in vivo activity against the gastrointestinal parasites Schistosoma mansoni [232], Ascaris suum [233], and Giardia lamblia [309]. These effects might be due to pelletierine alkaloids, unusual alkaloids which, among others, paralyze tapeworms so that they are easily expelled from the body by using a laxative [310]. Other compounds isolated from the fruit such as the phenolics gallagic acid and punicalagins exhibited in vitro activity against the malaria parasite Plasmodium falciparum [184].
As well, orally administered P. granatum juice or seed or flower extracts led to a significant reduction of blood glucose levels as well as those of blood lipids and lipoproteins in streptozotocin- or alloxan-induced diabetic rats [311, 312] and type II diabetic patients with hyperlipidemia [313]. These effects have been attributed to oleanolic, ursolic, and gallic acids [314], and might be associated with inhibition of the reabsorption of glucose in the proximal tubuli of the kidneys [315], an increased utilization of glucose by the peripheral tissues [311], and/or improved sensitivity of the insulin receptor [314]. Furthermore, P. granatum fresh, fermented or concentrated fruit juice as well as cold-pressed seed oil elicited meaningful anti-inflammatory activities in vitro and in experimental mouse and rat models of colitis and osteoarthritis [316, 317].
There are many pharmacological indications for the antimicrobial activity of P. granatum. Extracts from leaves, roots, bark, rhizomes, seeds, fruit peels, fruit juice, whole fruit, as well as flowers prepared with solvents of different polarities, showed broad and strong activity against various bacterial strains (see, for instance, references [184, 187, 189, 318, 319]), including multidrug-resistant pathogenic bacteria [184, 318]. The antibacterial activity was more pronounced against Gram-positive than against Gram-negative bacteria [319], was often highest in the methanol extracts or fractions [246], and has also been attributed to several phenolic compounds [184, 189, 318, 319].
There is ample evidence for antifungal activity of P. granatum. For instance, extracts of various parts of the plant were active against dermatophytic fungi [188]. An extract of the fruit formulated as a gel elicited antifungal activity in individuals with candidosis associated with denture stomatitis [186]. Extracts from the fruit peel, seed, juice, and whole fruit were active against industrially important fungi such as Mucor indicus, Penicillium citrinum, Rhizopus oryzae, and Trichoderma reesei [187]. Furthermore, several fractions of the fruit juice obtained by column chromatography, as well as purified ellagic acid, gallagic acid, punicalins, and punicalagins exerted in vitro activity against the common pathogens Candida albicans and Candida neoformans as well as Aspergillus fumigatus [184]. Punicalagin isolated from the fruit peel also showed strong in vitro activity against Candida albicans and Candida parapsilosis, and acted synergistically with fluconazole [185].
In addition, extracts from various parts of the plant were active against the plant pathogenic fungi Pyricularia oryzae, Colletotrichum falcatum, Dreschlera rostrata, and Curvularia lunata, completely inhibiting spore germination of the latter two species [188]. Particularly the fruit peel seemed to possess potent activity against plant pathogenic fungi. Preparations from this part of the plant were active against the plant pathogenic fungi Penicillium digitatum [190], Botrytis cinerea [185, 186, 188, 189, 190, 191, 192], and Fusarium sambucinum [193], both in vitro and in vivo. These fungal species are responsible for green rot in citrus fruit, bunch rot in grapes, and dry rot on potato tubers, respectively. Again, methanolic extracts seemed to be more effective than water extracts [191], and the main antifungal constituents of P. granatum seemed to be phenolic compounds such as ellagic acid derivatives like punicalagin, castagalagin, and granatin; gallotannins and procyanidins; cyanidin 3-glucoside and pelargonidin 3-glucoside; as well as catechins, kaempferol, and quercetin [187, 190, 192, 318].
5.6 Myristicaceae—Virola surinamensis (Rol. ex Rottb.) Warb
Virola surinamensis (Rol. ex Rottb.) Warb, commonly known as baboonwood or (white) ucuba is probably native to the tropical and subtropical parts of northern Brazil, Venezuela, Guyana, French Guiana, Suriname, Panama, Costa Rica, and the West Indies, where it can be found in moist lowland forests, swamps, and heavily degraded former forests. It is an evergreen tree that grows 25–35 m tall and has a straight, widening cylindrical trunk that is free of branches for 15–18 m (Figure 10). V. surinamensis is called ‘babun udu’ in Suriname, because the reddish-brown-color of the hardwood (‘udu’ in Surinamse) resembles the fur color of the red howler monkey called ‘babun’ in the country [145]. The tree is much in demand for its light-weight wood and is listed as globally ‘endangered’ on the IUCN Red List of Threatened Species [320].
Figure 10.
The baboonwood Virola surinamensis (Rol. ex Rottb.) Warb. (Myristicaceae) (from: https://images.app.goo.gl/kjANY1chTGChw2DF6).
V. surinamensis produces grey seeds of about 2 cm long and 1.5 cm wide which are surrounded by a brilliant red nutritious aril that attracts several species of birds and monkeys which function as its primary seed dispersers. The seeds contain 60–70% fat (consisting of, among others, 69% myristic acid, 13% lauric acid, and 7% palmitic acid), as well as vitamins A and C and traces of oleic acid and linoleic acid [321]. The fat is called ucuúba seed butter (‘ucuúba’ is the indigenous name of the tree, ‘ucu’ meaning ‘grease’ and ‘yba’ meaning ‘tree’) and is edible, but is also used in a wide assortment of skin-conditioning products [322].
Leaf, fruit, stembark, and root of V. surinamensis are extensively used for preparing traditional medicines, particularly by the Indigenous peoples of the Amazon including those from Suriname. Some of the many indications are rheumatism, arthritis, and inflammation; coughing and other symptoms of respiratory disease; aphthae, mouth sores, and abscessed teeth; conjunctivitis; skin problems including rash caused by scabies, infected wounds and bacterial infections such as erysipelas; gastrointestinal troubles such as dyspepsia, ulcers, gastritis, intestinal worms, and bloody diarrhea; hemorrhoids and piles; malaria; bladder problems; infertility; and fungal infections [145, 151, 323, 324]. Interestingly, several Amazonian tribes process the red sap from the inner bark into a hallucinogenic snuff or an intoxicating paste [325]. This substance contains psychoactive substances including hallucinogenic tryptamines such as N, N-dimethyltryptamine and 5-methoxy-N, N-dimethylpritmamine, and psychedelic β-carbolines such as harmine, harmaline, and tetrahydroharmine [325]. The sap would also be efficacious against ringworm, oral thrush, and jock itch [323].
Pharmacological studies have shown substantial activity of V. surinamensis preparations against the cercaria of the parasitic flatworm Schistosoma mansoni that causes bilharzia [326]; the tripomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease [327, 328]; cultured promastigotes and/or amastigotes of several species of Leishmania that are responsible for the severe forms of leishmaniasis including kala-azar [329, 330]; the larvae of Aedes aegypti, a known factor of dengue fever, chikungunya, Zika fever, and yellow fever viruses [331]; those of the oriental latrine fly Chrysomya megacephala that can cause accidental myiasis [332]; and the trophozoite stages of Plasmodium falciparum that causes malaria [324]. These activities might be attributable to various lignans and neolignans such as grandisin in the leaf and twig of the plant and/or constituents in the leaf essential oil such as the sesquiterpenoid nerolidol [327, 328, 329, 330, 331, 332]. Grandisin also elicited anti-inflammatory and antinociceptive effects in laboratory mice [333]. And an ethanolic extract of the resin stem bark (that contains the antioxidant flavonoid epicatechin) prevented the development of ethanol-, indomethacin-, stress-, or pylorus ligature-induced ulcers in laboratory mice [334].
Pharmacological support for the folkloristic claims of antifungal effects of V. surinamensis is scant. A dichloromethane extract from the root and the fractions obtained from this extract, were active against cultures of Cladosporium cladosporioides that can cause fruit rot disease in red wine grapevine but also allergies and asthma in humans [194]. Furthermore, an ethanol extracts from the stembark was active against several species of Candida [239]. The antifungal activity has been attributed to the flavonoids 7-hydroxyflavanone and 7-hydroxy-4′-methoxyisoflavone and was ten times greater than that found for nystatin [194], but also to (neo)lignans in leaf and seed of the plant [335]. In the latter case, the antifungal activity has been associated with the inhibition of the polymerization or assembly of the fungal cell wall [336]. Interestingly, the saturated fatty acid capric acid (or decanoic acid) in V. surinamensis seed, leaf, and bark elicited meaningful activity against the parasitic dermatophyte Microsporum gypseum [197] and forty isolates of Candida [196]. Capric acid also displayed synergism with fluconazole and nystatin against drug-resistant Candida isolates from oral thrush in neonates [196]. However, the amounts of this compound in at least V. surinamensis seed (around 1%) [321] seem too low to be responsible for the antifungal activity.
5.7 Myrtaceae—Psidium guajava L
The common guava Psidium guajava L. is an evergreen tree that grows to a height of 3–10 m and is native to South America, Central America, and the Caribbean. It is widely cultivated for its edible fruit in many tropical and subtropical regions. Depending on the cultivar, the fruit can be ovoid or pear-shaped; have a green, yellow, or red skin and white-, pink-, or red-colored fleshy pulp; and range in size from as small as an apricot to as large as a grapefruit (Figure 11). Edible oil is obtained from the seeds [337], and extracts from the fruit are included in various cosmetic products such as shampoos to confer a pleasantly fresh scent [338].
Figure 11.
The guava Psidium guajava L. (Myrtaceae) (from: https://images.app.goo.gl/Cdw93GHRJaJ2jHYg7).
Preparations from the young and ripe fruit as well as leaf, stem, stembark, and rootbark from P. guajava are used in many traditional medical systems in Africa, Asia, Central America, and the Caribbean. A few indications are diarrhea, constipation, spasms, and ulcers; colds, sore throat, coughs, laryngitis, and bronchitis; menstrual disorders; gonorrhea; inflammatory disorders such as rheumatism; diabetes mellitus; hypertension; sprains and pains; vertigo, epilepsy, and convulsions; a wide variety of skin complaints; as well as parasitic and microbial infections including those causing vaginal discharge and ringworm [339, 340]. In Suriname, P. guajava preparations are, in addition, used in genital steam baths for cleansing the vagina and preventing microbial infections [155].
Some of the traditional uses of P. guajava have been validated by phytochemical and pharmacological studies (see, for instance, references [341, 342]). Aqueous and ethanolic leaf extracts elicited antidiarrheal activity in mice and rats treated with Castor oil [343] that was comparable to that caused by loperamide and might occur through inhibition of gut motility [343]. The leaf essential oil was efficacious in diarrhea associated with infantile rotaviral enteritis [344]. And the polyphenolic fraction of an aqueous leaf extract displayed spasmolytic activity in an isolated guinea-pig ileum preparation precontracted with acetylcholine and/or KCl [345]. Notably, a double-blind clinical study with a phytodrug called QG5 developed from P. guajava leaf, produced a decrease in the duration of abdominal pain, presumably due to the antispasmodic activity of quercetin in the preparation [346].
The presumed efficacy of P. guajava against respiratory disorders was supported by the antitussive activity of leaf extracts in rats and guinea pigs exposed to a capsaicin aerosol [347]. Evidence for anti-inflammatory and antinociceptive activity of the plant was provided by the inhibitory effects of an aqueous leaf extract on fresh egg albumin-induced paw edema in rats and thermally and chemically induced nociceptive pain in mice [348]. And indications for central modulatory effects of P. guajava came from the suppression of central nervous system activity and the prolongation of pentobarbital-induced sleeping time in mice that had been given methanol leaf extracts or non-polar fractions therefrom [349, 350]. These observations have been attributed to terpenes and possibly also flavonoids in the extracts [349, 351].
Studies with both laboratory animals and human subjects also supported the antihypotensive and antidiabetic activities of P. guajava. Leaf preparations produced vasorelaxation in spontaneously-contracting portal veins as well as rat aortic ring preparations of normotensive rats [352]. Importantly, randomized clinical studies found that the consumption of the fruit led to small but statistically significant positive effects on blood pressure, total blood cholesterol and triglyceride levels, as well as HDL cholesterol in hypertensive patients [353, 354]. And intraperitoneal administration of an aqueous extract of the unripe fruit or from the fruit peel led to clear hypoglycemic and antidiabetic activities in streptozotocin-treated diabetic rats [355]. The ripe fruit without peel was more efficacious in diabetic patients when compared to the fruit with peel [356].
Evidence for antiparasitic activity of P. guajava was provided by the in vitro inhibitory effect of a polyphenolic fraction of an aqueous leaf extract on the growth of Entamoeba histolytica (that causes amoebic dysentery) [345]; the potent activity of an aqueous stembark extract against the malaria parasite Plasmodium falciparum in a lactate dehydrogenase assay [357]; and the meaningful anticestodal efficacy of an aqueous leaf extract against experimental Hymenolepis diminuta (tapeworm) infection in rats [358].
Support for antibacterial effects of P. guajava came from the activity of aqueous and organic extracts from the leaf and the stembark against the main causative agent of acne lesions, Propionibacterium acnes, and other organisms isolated from these lesions [359]; two clinical isolates of the gastrointestinal tract, Escherichia coli and Staphylococcus aureus [360]; a wide variety of clinically important bacterial strains (see, for instance, references [198, 361]); as well as multidrug-resistant clinical isolates of Staphylococcus aureus [362] and a multidrug-resistant strain of Vibrio cholera [363]. The antibacterial activity might be associated with inhibition of adherence by certain lectins in the fruit [364] or phenolic compounds including flavonoids in the leaves [198, 361].
Most studies on the antifungal activity of P. guajava have been carried out with preparations of the leaf from the plant. Thus, extracts from this part of the plant obtained with various organic solvents or hot water elicited broad and meaningful activity against species in the genera Candida, Saccharomyces, Cryptococcus, Trichosporon, Aspergillus, Sporothrix, and Microsporum [198, 199, 200, 201, 202, 203]. The antifungal activities in the leaf preparations potentiated that of fluconazole [203, 204] and have been attributed to phenolic compounds including tannins, coumarins, and flavonoids such as quercetin, and/or terpenoids [198, 201, 203, 361]. The former supposition is supported by the activity of tannic and flavonoid fractions from the leaf against several species of Candida [204] and the inhibitory effects of plant phenolic compounds on the biosynthesis of ergosterol for assembling the fungal plasma membrane [365].
As well, a methanolic extract from the ripe fruit was active against strains of Arthrinium sacchari that can cause damping-off disease of wheat (collapse and overgrowth of emerging seedlings), as well as the melanin-containing ‘black yeast’ Chaetomium funicola that can cause pheohyphomycosis, a dark-brown-colored infection of skin and subcutis, paranasal sinuses, or central nervous system [206]. Furthermore, a tincture of P. guajava bark effectively killed various dermatophytes in the genera Trichophyton and Microsporum [205], while organic extracts from the twigs inactivated Candida albicans and Aspergillus niger [204].
5.8 Rananculaceae—Nigella sativa L
The black caraway (or black cumin) Nigella sativa L. is an annual flowering plant that is native to a large region that includes eastern Mediterranean, northern Africa, the Indian Subcontinent, and western Asia. It grows 20–30 cm tall, and bears relatively large fruits made up of an inflated capsule composed of three to seven united follicles, each containing numerous black seeds. The plant is mainly cultivated for the edible seeds (called ‘black cumin seeds’; Figure 12) which have a pungent, bitter taste and smell, and are used as a spice, flavoring, and food preservative [366].
Figure 12.
The black caraway Nigella sativa L. (Rananculaceae) (from: https://images.app.goo.gl/s29DmisCFu3opVT78).
In addition, the seeds and the seed oil (called ‘black seed oil’) are widely used for treating, among others, inflammatory conditions such as rheumatism, as well as respiratory conditions, gastrointestinal problems, diabetes mellitus; elevated blood cholesterol levels, a weakened immune system, parasitic infections, and microbial infections such as athlete’s foot, nail infections, ringworm, and thrush [367, 368, 369]. Relatively recently, Ayurvedic supplements of N. sativa seed oil in capsule or softgel form have been promoted in various countries including Suriname as a remedy for several of these conditions including skin, hair, and nail problems.
Some of the therapeutic properties of N. sativa have been attributed to the monoterpene thymoquinone, a major bioactive component of the seed essential oil [207] that is virtually non-toxic to humans [208]. For instance, exposure of cultured pancreatic cancer cells to thymoquinone led to a reduction in markers of inflammation [209]. This was consistent with the inhibitory effects of a ground seed extract on inflammation in the cerebellum and medulla of a rat model of multiple sclerosis [210] and with the improvement of inflammation markers in the serum of patients with rheumatoid arthritis who had received the seed oil [211]. Furthermore, N. sativa seed oil protected rats from developing stomach ulcers following exposure to acetylsalicylic acid [370] and from liver damage caused by aflatoxin B1 [212], and caused a decrease in levels of blood sugar [213], serum triglycerides and LDL [214]. N. sativa seed preparations and seed oil also elicited meaningful antimicrobial activity. Antibacterial effects were seen with a topical formulation against a staphylococcal skin infection in children [215] and against many cultured bacterial strains including methicillin-resistant Staphylococcus aureus isolates from the wounds of diabetic patients [216, 371].
Support for antifungal activity of N. sativa was provided by the inhibitory effects of diethyl ether, methanol, and aqueous seed extracts on the growth of Candida albicans in vitro [372] and on the infestation of liver, spleen, and kidneys of mice inoculated with the fungus [373]. The extracts also inactivated various dermatophytic fungi [217, 218], albeit to a lesser extent when compared to griseofulvin [217]. However, another study only found an inhibitory effect of organic seed extracts on the formation of Candida albicans colonies in the organs of experimental animals, not of aqueous extracts [374]. Thymoquinone also inhibited the growth of dermatophytes [217] as well as that of intravaginally administered Candida albicans in mice immunosuppressed by subcutaneously injected methyl prednisolone [375]. The antifungal activities of thymoquinone (that is rather lipophilic) presumably occurred as a result of the perturbation of fungal plasma membrane proteins [375].
Furthermore, the seed essential oil of N. sativa exerted excellent and broad activity against various species of Aspergillus, Curvularia, Microsporum, Penicillium, Trichoderma, Candida, Chaetomium, Fusarium, Trichophyton, and Chrysosporium [376, 377, 378, 379, 380]. However, in another study, the oil did not affect the growth of Aspergillus flavus and Aspergillus parasiticus in vitro, but inhibited the production of aflatoxin B1 by at least one-third [381]. The antifungal activity of N. sativa seeds has been hypothesized to be attributable to (an) ingredient(s) that kill(s) fungi by stimulating the production of nitric oxide by host granulocytes and monocytes [382]. A subsequent study reported two peptides called defensins and designated Ns-D1 and Ns-D2 that displayed strong activity against phytopathogenic fungi, presumably by interacting with specific sphingolipids in the fungal plasma membrane [383].
5.9 Rutaceae—Aegle marmelos (L.) Corrêa
The bael tree or Aegle marmelos (L.) Corrêa is a slow-growing deciduous tree that can reach a height of 10–15 m and is native to the northern parts of India. It is mainly cultivated for its edible aromatic, sweet-tasting, yellow-colored fruit (Figure 13) in that country as well as in other south-eastern Asian countries such as Sri Lanka, Thailand, and Malaysia. Young leaves and shoots of A. marmelos are eaten as salad greens and contain the alkaloid aegeline (N-[2-hydroxy-2 (4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide) that would reduce appetite, produce weight loss, improve athletic performance, and increase energy [384]. For these reasons, aegeline has been incorporated in dietary supplements that have been marketed for weight loss and muscle building [385], even though there is no sound scientific evidence to support these uses. More importantly, aegeline has been associated with potentially fatal liver damage [386], and the more than fifty cases of acute hepatitis including several instances of fatal, acute liver failure have led to the withdrawal from the market of an aegeline-based slimming product called OxyElite Pro® [386].
Figure 13.
The Indian bael tree Aegle marmelos (L.) Corrêa (Rutaceae) (from: https://images.app.goo.gl/BkkX6CZgxx1q5Whv7).
Nevertheless, A. marmelos is extensively used in the traditional medical systems of the Indian subcontinent [387] and those of the Indian diaspora in Suriname [155]. Preparations from leaf, stembark, root, fruit, and seed are used against, among others, stomach pain, peptic ulcers, diarrhea, amoebic dysentery, constipation, and jaundice; rheumatoid arthritis, gout, and swollen joints; diabetes mellitus; high blood pressure; asthma; anemia; bone fractures; agitation and insomnia; wounds; skin problems such as leucoderma; as well as microbial infections [387, 388].
Pharmacological studies have validated many of the ethnomedicinal uses of A. marmelos (see, for instance, references [388, 389]). Thus, a chloroform root extract was effective against castor oil-induced diarrhea in laboratory rodents and inhibited the in vitro growth of various cultured diarrhea-causing species of bacteria—particularly Vibrio cholerae, Escherichia coli, and Shigella spp.—at a comparable degree as the fluoroquinolone antibiotic ciprofloxacin [390]. A methanolic leaf extract elicited considerable anti-inflammatory, antinociceptive, and antipyretic activities in rats and mice [391]. And leaf, callus, and fruit extracts displayed notable hypoglycemic and antihyperlipidemic effects in alloxan- and streptozotocin-treated mice, rats, and rabbits [392, 393, 394]. This was presumably due to the stimulation of glucose uptake by the peripheral tissues [392] and/or insulin secretion from the pancreatic β-cells [392, 393].
A methanolic leaf extract formulated as an ointment or an injectable preparation for intraperitoneal administration, stimulated the healing of excision and incision wounds in rats to a comparable degree as the topical nitrofuran antimicrobial compound nitrofurazone [395]. Preparations from A. marmelos leaf, fruit, seed, and root also displayed antibacterial and antifungal activity. The antibacterial activity was directed against a broad range of Gram-positive as well as and Gram-negative bacteria (see, for instance, references [219, 220, 396]) including multidrug resistant strains [396]. Some of the pharmacological activities of A. marmelos have been attributed to the presence of coumarins, monoterpenoids (such as cuminaldehyde), phenolic compounds (such as flavonoids and eugenol), alkaloids, tannins, and essential oils in the plant [221, 222].
Evidence for antifungal properties of A. marmelos was provided by the meaningful activity of the leaf essential oil against a variety of yeast-like and filamentous fungal species including clinical isolates of dermatophytic fungi such as those causing ringworm [219, 220, 221, 222, 223, 224, 225, 226, 227]. Furthermore, the essential oil of the plant completely inhibited spore germination of dermatophytic and plant pathogenic Fusarium fungal species in vitro, including that of a highly resistant species, Fusarium udum, the causative agent of wilt disease in the pigeon pea (characterized by the disruption of the flow of water in the xylem transport tissue of the plant) [227]. In addition, water, methanol, and ethanol leaf extracts as well as fractions from them, exerted potent antifungal activity against clinical isolates of dermatophytic fungi in the genera Trichophyton, Microsporum, and Epidermophyton [397].
As well, fractions from chloroform leaf and fruit extracts showed substantial activity in pot cultures against the plant pathogenic fungi Fusarium oxysporum f.sp. ciceris [228] and Pythium debaryanum [398], the causative agents of wilt of chickpea, and damping-off in peanut, beet, and tobacco, respectively. Notably, the addition of the leaf methanol extract to the bio-agents Trichoderma viride and/or Pseudomonas fluorescens suppressed chickpea wilt disease more when compared to either substance alone [228]. Preparations from A. marmelos seed also exhibited considerable in vitro activity against various species of Trichophyton and Aspergillus, as well as Epidermophyton floccosum (that causes skin and nail infections in humans) and Candida albicans [399, 400, 401, 402]. And an ethanolic extract of the root showed activity against Aspergillus fumigatus and Trichophyton mentagrophytes [403]. The antifungal activity of the leaf essential oil has been attributed to certain terpenoids that inhibited spore germination by interfering with Ca2+-dipicolonic acid metabolism [220, 227], a metabolic pathway involved in the regulation of the resilience of macromolecules including DNA to stressors such as heat [404].
6. Concluding remarks
Since their emergence on Earth, humans have explored the biodiversity to improve their well-being [405]. For this purpose, various plants, animals, and micro-organisms have been used as food, spices, shelter, poisons on arrow- and spearheads for hunting and warfare, cosmetics, stimulants, as well as medicines. Insight into the latter uses has provided unlimited opportunities for new drug leads because of nature’s enormous chemical diversity and the production of a myriad of drugs that became an essential part of health care systems throughout the world. For instance, the antineoplastic agents vincristine and paclitaxel have first been identified in the periwinkle plant Catharanthus roseus [406] and the Pacific yew Taxus brevifolia [407], respectively. The angiotensin-converting enzyme inhibitor captopril and its derivatives for treating hypertension and some types of congestive heart failure, have been developed from the venom of the Brazilian viper Bothrops jararaca [408]. And exenatide for treating type 2 diabetes mellitus was originally isolated from the venom of the Gila monster Heloderma suspectum [409].
The bacterial species Saccharopolyspora erythraea and Streptomyces nodosus gave the antibacterial agent erythromycin [410], and the antifungal and antileishmanial agent amphotericin B [411], respectively. And as mentioned throughout this monograph, the fungal species Penicillium chrysogenum, Tolypocladium inflatum, and Aspergillus terreus were at the basis of identifying β-lactam antibiotics such as the penicillins [12], the immunosuppressive agent tacrolimus [13], and the specific LDL-lowering HMG-CoA reductase-inhibiting statins that reduce the risk of arterial blockage, a heart attack, a stroke, and diabetes mellitus [14].
This monograph has presented data about the antifungal activities of nine plants that are traditionally used for treating mycoses in Suriname. The plants were the taro Colocasia esculenta (Araceae), the milkweed Euphorbia hirta (Euphorbiaceae), the holy basil Ocimum tenuiflorum (Lamiaceae), the avocado Persea americana (Lauraceae), the pomegranate Punica granatum (Lythraceae), the baboonwood Virola surinamensis (Myristicaceae), the guava Psidium guajava (Myrtaceae), the black caraway Nigella sativa (Rananculaceae), and the golden apple Aegle marmelos (Rutaceae). Preparations from these plants showed good and broad antifungal properties in vitro. In addition, most of the samples also displayed various other pharmacological activities including antiparasitic, antibacterial, and antiviral activity. An extract of P. granatum fruit formulated as a gel even elicited antifungal activity in individuals with candidosis associated with denture stomatitis [186]. And there are in most cases also valuable indications about the pharmacologically active compound(s) and the mechanism(s) of action.
These data are encouraging, providing preliminary indications of the usefulness and potential toxicity of the plant samples, but do not reflect their clinical efficacy and usefulness. It is therefore imperative to properly evaluate the plant preparations for their chemical stability, spectrum of antifungal activity in the clinical setting, susceptibility to efflux pumps, bioavailability and degree of protein binding and inactivation by serum and hepatic enzyme systems, and many other pharmacokinetic and pharmacodynamics aspects. This is all the more important because of two reasons. First, the development of resistance to available antifungal drugs including the spread of multidrug-resistant fungal strains, is becoming a growing problem in many parts of the world [412]. Second, despite the availability of modern allopathic antifungal drugs, about 80% of the world population residing in the developing world rely on herbal medicinal products as a primary source of healthcare [413]. It is just and fair to provide sound scientific evidence on the clinical efficacy of these products for treating fungal infections.
\n',keywords:"fungal infections, Suriname, medicinal plants, traditional uses, phytochemistry, pharmacology, antifungal activity",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/80536.pdf",chapterXML:"https://mts.intechopen.com/source/xml/80536.xml",downloadPdfUrl:"/chapter/pdf-download/80536",previewPdfUrl:"/chapter/pdf-preview/80536",totalDownloads:15,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:0,impactScoreQuartile:0,hasAltmetrics:0,dateSubmitted:null,dateReviewed:"January 17th 2022",datePrePublished:"February 23rd 2022",datePublished:"April 20th 2022",dateFinished:"February 20th 2022",readingETA:"0",abstract:"Fungi are unicellular or multicellular thick-walled eukaryotic organisms that are not capable of photosynthesis and are placed in a biological kingdom of their own. They are ubiquitous in our environment, and include tens of thousands, perhaps even millions of species of yeasts, rusts, smuts, mildews, molds, and mushrooms. Together with bacteria, fungi are the principal decomposers of plant materials such as cellulose and lignin, fulfilling vital ecological functions in all terrestrial habitats. Some species of fungi are also of major importance in households (for instance, as foods such as edible mushrooms), medicine (for instance, as producers of antibiotics such as penicillin), and industry (for instance, for making bread, wine, and cheese). About 300 fungal species cause infections in humans, varying from relatively harmless skin complaints such as pityriasis versicolor to potentially life-threatening systemic syndromes such as candidiasis. Fortunately, a broad armamentarium of efficacious antifungal drugs has been developed, ranging from topical nystatin to parenteral amphotericin B. In addition, most, if not all traditional medical systems throughout the world have identified a large assortment of plant-based remedies for treating these infections. This also holds true for the multi-ethnic and multicultural Republic of Suriname (South America), where plant-based traditional medicines are abundantly used, either alone or in conjunction with allopathic medications. This monograph extensively addresses nine plants that are traditionally used for treating fungal infections in Suriname, and explains the phytochemical and pharmacological rationales for these applications. These sections are preceded by some general observations about the Fungal Kingdom; a few words about the characteristics of fungi, their taxonomy, and their significance to humans; information about fungal infections as well as the available forms of treatment; and some details about Suriname including health aspects, the health care structure, and the main fungal infections in the country. The monograph is concluded with an evaluation of the status of the Surinamese herbal antifungal substances and the previsions of developing them into mainstream antifungal formulations.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/80536",risUrl:"/chapter/ris/80536",book:{id:"10926",slug:"traditional-plant-based-forms-of-treatment-of-fungal-infections-in-suriname-phytochemical-and-pharmacological-rationale"},signatures:"Dennis R.A. Mans",authors:[{id:"193905",title:"Dr.",name:"Dennis",middleName:"R. A.",surname:"R.A. Mans",fullName:"Dennis R.A. Mans",slug:"dennis-r.a.-mans",email:"dennismans16@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/193905/images/system/193905.png",institution:{name:"Anton de Kom University of Suriname",institutionURL:null,country:{name:"Suriname"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Characteristics of fungi, their taxonomy, and their significance to humans",level:"1"},{id:"sec_2_2",title:"2.1 Characteristics",level:"2"},{id:"sec_3_2",title:"2.2 Taxonomy",level:"2"},{id:"sec_4_2",title:"2.3 Significance of fungi to humans",level:"2"},{id:"sec_6",title:"3. Fungal infections, epidemiology, and treatment",level:"1"},{id:"sec_6_2",title:"3.1 Types of fungal infections",level:"2"},{id:"sec_7_2",title:"3.2 Epidemiology",level:"2"},{id:"sec_8_2",title:"3.3 Treatment",level:"2"},{id:"sec_10",title:"4. Suriname: the country profile, health and health care, and fungal infections",level:"1"},{id:"sec_10_2",title:"4.1 Health and health care in Suriname",level:"2"},{id:"sec_11_2",title:"4.2 Fungal infections in Suriname",level:"2"},{id:"sec_13",title:"5. Traditional herbal treatments of fungal infections in Suriname",level:"1"},{id:"sec_13_2",title:"5.1 Araceae—Colocasia esculenta (L.) Schott",level:"2"},{id:"sec_14_2",title:"5.2 Euphorbiaceae—Euphorbia hirta L",level:"2"},{id:"sec_15_2",title:"5.3 Lamiaceae—Ocimum tenuiflorum L",level:"2"},{id:"sec_16_2",title:"5.4 Lauraceae—Persea americana Mill",level:"2"},{id:"sec_17_2",title:"5.5 Lythraceae—Punica granatum L",level:"2"},{id:"sec_18_2",title:"5.6 Myristicaceae—Virola surinamensis (Rol. ex Rottb.) Warb",level:"2"},{id:"sec_19_2",title:"5.7 Myrtaceae—Psidium guajava L",level:"2"},{id:"sec_20_2",title:"5.8 Rananculaceae—Nigella sativa L",level:"2"},{id:"sec_21_2",title:"5.9 Rutaceae—Aegle marmelos (L.) Corrêa",level:"2"},{id:"sec_23",title:"6. Concluding remarks",level:"1"}],chapterReferences:[{id:"B1",body:'Heitman J, Howlett B, Crous PW, Stukenbrock E, James T, Gow NAR, editors. The Fungal Kingdom. Washington, DC: American Society for Microbiology; 2017. DOI: 10.1128/9781555819583'},{id:"B2",body:'Berbee ML, Taylor JW. Dating the molecular clock in fungi—How close are we? Fungal Biology Reviews. 2010;24:1-16. 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Hypoglycemic and hypolipidemic effect of Aegle marmelos (L.) leaf extract on streptozotocin-induced diabetic mice. International Journal of Pharmacology. 2007;3:444-452'},{id:"B393",body:'Sevugan A, Subramanian K, Balamuthu K, Abdul BAA, Mohammed AA, Mandali VR. Antidiabetic activity of leaf and callus extracts of Aegle marmelos in rabbit. Science Asia. 2008;2008(34):317-321'},{id:"B394",body:'Patel AR, Garach D, Chakraborty M, Kamath JV. Aegle marmelos (Linn.): A therapeutic boon for human health. Indian Journal of Research in Ayurveda and Pharmacy. 2012;3:159-163'},{id:"B395",body:'Jaswanth A, Loganathan V, Manimaran S. Wound healing activity of Aegle marmelos. Indian Journal of Pharmaceutical Sciences. 2001;63:41-44'},{id:"B396",body:'Rani P, Khullar N. Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi. Phytotherapy Research. 2004;18:670-673. DOI: 10.1002/ptr.1522'},{id:"B397",body:'Balakumar S, Rajan S, Thirunalasundari T, Jeeva S. Antifungal activity of Aegle marmelos (L.) Correa (Rutaceae) leaf extract on dermatophytes. Asian Pacific Journal of Tropical Biomedicine. 2011;1:309-312. DOI: 10.1016/S2221-1691(11)60049-X'},{id:"B398",body:'Yogeshwar M, Gade RM, Shitole AV. Evaluation of antifungal activities of extracts of Aegle marmelos, Syzygium cumini and Pongamia pinnata against Pythium debaryanum. Indian Journal of Pharmaceutical Sciences. 2017;79:377-384. DOI: 10.4172/pharmaceutical-sciences.1000240'},{id:"B399",body:'Singh KV, Bhatt SK, Sthapak JK. Antimicrobial and anthelmintic properties of the seeds of Aegle marmelos. Fitoterapia. 1983;54:261-264'},{id:"B400",body:'Banerjee AK, Kaul VK, Nigam SS. Chemical, microbial and anthelmintic examination of the seeds of Aegle marmelos Corr. Indian Drugs. 1984;21:217-218'},{id:"B401",body:'Mishra BB, Kishore N, Tiwari VK, Singh DD, Tripathi V. A novel antifungal anthraquinone from seeds of Aegle marmelos Correa (family Rutaceae). Fitoterapia. 2010;81:104-107. DOI: 10.1016/j.fitote.2009.08.009'},{id:"B402",body:'Mishra BB, Singh DD, Kishore N, Tiwari VK, Tripathi V. Antifungal constituents isolated from the seeds of Aegle marmelos. Phytochemistry. 2010;71:230-234. DOI: 10.1016/j.phytochem.2009.10.013'},{id:"B403",body:'Pitre S, Srivastava SK. Pharmacological, microbiological and phytochemical studies on the roots of Aegle marmelos. Fitoterapia. 1987;58:194-197'},{id:"B404",body:'Sliemandagger TA, Nicholson WL. Role of dipicolinic acid in survival of Bacillus subtilis spores exposed to artificial and solar UV radiation. Applied and Environmental Microbiology. 2001;2001(67):1274-1279. DOI: 10.1128/aem.67.3.1274-1279.2001'},{id:"B405",body:'Mans DRA. From forest to pharmacy: Plant-based traditional medicines as sources for novel therapeutics. Academia Journal of Medicinal Plants. 2013;1:101-110'},{id:"B406",body:'Van Der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R. The Catharanthus alkaloids: Pharmacognosy and biotechnology. Current Medical Chemistry. 2004;11:607-628. DOI: 10.2174/0929867043455846'},{id:"B407",body:'Kingston DG, Newman DJ. Taxoids: Cancer-fighting compounds from nature. Current Opinion in Drug Discovery and Development. 2007;10:130-144'},{id:"B408",body:'Vane JR. The history of inhibitors of angiotensin-converting enzyme. Journal of Physiology and Pharmacology. 1999;50:489-498'},{id:"B409",body:'Furman B. The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent. Toxicon. 2012;59:464-471. DOI: 10.1016/j.toxicon.2010.12.016'},{id:"B410",body:'Shafia S, Chandluri P, Ganpisetti R, Lakshmi BVS, Swami PA. Erythromycin use as broad spectrum antibiotic. World Journal of Pharmaceutical and Medical Research. 2016;2:23-26'},{id:"B411",body:'Cuddihy G, Wasan EK, Di Y, Wasan KM. The development of oral amphotericin B to treat systemic fungal and parasitic infections: Has the myth been finally realized? Pharmaceutics. 2019;11:99. DOI: 10.3390/pharmaceutics11030099'},{id:"B412",body:'Perlin DS, Shor E, Zhao Y. Update on antifungal drug resistance. Current Clinical Microbiology Reports. 2015;2:84-95. DOI: 10.1007/s40588-015-0015-1'},{id:"B413",body:'Bodeker C, Bodeker G, Ong CK, Grundy CK, Burford G, Shein K. WHO Global Atlas of Traditional, Complementary and Alternative Medicine. Geneva, Switzerland: World Health Organization; 2005'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Dennis R.A. Mans",address:"dennismans16@gmail.com;, dennis_mans@yahoo.com",affiliation:'
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1. Introduction
1.1 Data Mining
Data mining may be thought of as a natural progression of information technology. It can be simply defined as a procedure for searching, gathering, filtering, and analyzing data. It’s the method of extracting useful knowledge from vast volumes of data kept in databases, data centers, or other data repositories. Database technology, statistics, artificial intelligence, machine learning, high-performance computing, pattern recognition, neural networks, data visualization, information retrieval, image and signal processing, and spatial data analysis are all techniques used in data mining. Data mining allows for the extraction of interesting knowledge, regularities, or high-level information from databases, which can then be viewed or browsed from various perspectives.
It deals with the secondary study of massive databases in order to uncover previously unknown relationships that are of interest or benefit to database owners. It can be thought of as computer-assisted exploratory data analysis of massive, complex data sets from a statistical standpoint. Data mining is having a big effect in business, industry, and science right now. It also opens up a lot of possibilities for new methodological advances in science. New issues occur, partly as a result of the sheer scale of the data sets in question, and partly as a result of pattern matching issues.
Decision making, process control, information management, and query processing are only a few of the applications for the newly discovered experience. As a result, data mining is recognized as one of the most exciting modern database technologies in the information industry, as well as one of the most important frontiers in database systems [1, 2]. This chapter will go into the basics of data mining as well as the data extraction techniques. Mastering this technology and its techniques will have significant advantages as well as a competitive edge.
1.2 The importance of data mining
Data mining has gotten a lot of attention in the information industry in recent years because of the widespread availability of massive quantities of data and the pressing need to transform the data into valuable information and knowledge. Business management, quality control, and market research, as well as engineering design and science discovery, will all benefit from the information and expertise acquired. Governments, private corporations, large organizations, and all industries are interested in collecting a large amount of data for business and research purposes [3, 4]. The following are some of the reasons why data mining is so important:
Data mining is the process of collecting vast amounts of data in order to extract information and dreams from it. The data industry is currently experiencing rapid growth, which has resulted in increased demand for data analysts and scientists.
We interpret the data and then translate it into useful information using this technique. This enables an organization to make more accurate and better decisions. Data mining aids in the creation of wise business decisions, the execution of accurate campaigns, the prediction of outcomes, and many other tasks.
We can evaluate consumer habits and insights with the aid of data mining. This results in a lot of growth and a data-driven business.
It’s important to remember that which data mining approach to utilize is mostly determined by the amount of data accessible, the type of data, and the dimensions. Although there are evident differences in the types of challenges that each data mining technique is best suited for, the nature of data from the real world, as well as the complicated ways in which markets, customers, and the data that represents them, means that the data is always altering. As a result, there is no obvious law that favors one technique over another. Decisions are sometimes made depending on the availability of experienced data mining analysts in one or more techniques. The preference of one technique over the others depends more on getting good resources and good analysts (Figure 1) [5].
Figure 1.
An overview of data mining process.
2. Related works
2.1 An overview of efficient data mining techniques
Data mining, according to Sandeep Dhawan, is the act of uncovering relationships within large data sets, as well as data trends, anomalies, changes, and significant statistical structures. Forming a hypothesis and then testing it against the dataset are two common data analysis strategies. Data mining techniques, on the other hand, find significant patterns in data automatically, and these patterns can be utilized to construct algorithms. The result or pattern detected should be genuine, intelligible, and valuable, which is a crucial issue when mining large data sets. It goes without saying that the efficiency of robust and intelligent data mining algorithms is essential for data warehousing and sustaining massive datasets. Data mining techniques are being used in practically every sector of the business world. There is rarely any sphere of life that does not have an input and integration of these data mining tools, from the music industry to film maintenance and medicine to sports. The study gave an overview of some of the most widely used data mining techniques, as well as their applications [3].
2.2 An overview of data mining techniques
The study offered an overview of some of the most widely used data mining algorithms. They were divided into two portions, each with its own theme:
Statistics, Neighborhoods, and Clustering are examples of traditional techniques.
Trees, Networks, and Rules: Next-Generation Techniques.
The authors discussed a variety of data mining methods so that the reader may see how each algorithm fits into the larger picture of data mining approaches. There were six different types of data mining algorithms presented in all. The Authors noted that, although there are a number of other algorithms and many variations of the techniques that were described, one of the algorithms is almost always used in real-world deployments of data mining systems [4].
3. Methods
Data mining is a multi-stage process that is accomplished in stages. Data mining is now widely employed in a variety of fields. Data mining has applications and uses in almost every aspect of life, and there are a variety of commercial data mining solutions available today [6, 7, 8].
3.1 Data mining process
Data mining is a collaborative effort that includes the following steps:
Collecting requirements
The collection and understanding of requirements is the first step in any data mining project. With the vendor’s business viewpoint, data mining analysts or users determine the requirement scope.
Data investigation
This move entails identifying and converting data patterns using data mining statistics. It necessitates collecting, assessing, and investigating the requirement or project. Experts comprehend the issues and challenges and translate them into metadata.
Data collection and planning
For the modeling phase, data mining experts translate the data into meaningful information. They use the ETL (Extract, Transform, and Load) method. They’re also in charge of inventing new data attributes. Various methods are employed here to view data in a structural format while preserving the value of data sets.
Modeling
Data experts use their best tools for this phase because it is so important in the overall data processing. To filter the data in an acceptable way, all modeling methods are used. Modeling and assessment are intertwined steps that must be completed at the same time to ensure that the criteria are correct. After the final modeling is completed, the accuracy of the final result can be checked.
Assessment or Evaluation
After efficient modeling, this is the filtering method. If the result is not acceptable, it is then passed back to the model. After a satisfactory result, the requirement is double-checked with the provider to ensure that no details are overlooked. At the end of the process, data mining experts evaluate the entire outcome.
Deployment
This is the final stage in the entire process. Data is presented to vendors in the form of spreadsheets or graphs by experts.
The following functions can be performed with data mining services [9, 10]:
Knowledge extraction: This is the procedure for finding useful trends in data that can be used in decision-making [11]. This is because decisions must be made on the basis of correct/accurate data and evidence.
Data collection: By scraping through linked websites and databases, it is possible to collect information about investors, portfolios, and funds using the web scraping process.
Web data: Web data is notoriously difficult to mine. This is due to the essence of the situation. Web data, for example, can be considered dynamic, meaning it changes over time. As a result, the data mining process should be replicated at regular intervals.
Data pre-processing: Typically, the data gathered is stored in a data center. This information must be pre-processed. Data mining experts should manually delete any data that is considered unimportant during pre-processing.
Market research, surveys, and analysis: Data mining can be used for product research, surveys, and market research. It is possible to collect data that would be useful in the creation of new marketing strategies and promotions.
Scanning of data: Data obtained and processed would be useless until it is scanned. Scanning is essential for detecting trends and similarities in the data.
Customer feedback: A company’s operations are heavily influenced by customer feedback and suggestions. Customers can easily find the details on forums, journals, and other sites where they can openly express their opinions.
News: With nearly all major newspapers and news outlets sharing their news online these days, it is easy to collect information on developments and other important topics. It is possible to be in a better place to compete in the market this way.
Up-to-date data: Keeping data up to date is important. The information gathered would be useless unless it is modified. This is to ensure that the data is valid before making decisions based on it.
Internet research: The internet is well-known for its vast amount of knowledge. It is obvious that it is the most important source of data. It is possible to collect a great deal of knowledge about various businesses, consumers, and company clients. Frauds can be detected using online resources.
Study of competitors: It’s important to know how your competitors are doing in the business world. It is important to understand both their strengths and weaknesses. Their methods of marketing and distribution can be mined, including their methods of reducing overall costs.
3.2 Advantages of data mining
Data mining and its features have many advantages. It raises the need for a data-driven market as it is combined with analytics and big data. Some of the benefits are as follows:
Manufacturing industries benefit from data mining by detecting defective devices and goods using engineering data. This aids in the removal of defective goods from the stock list.
It assists government agencies in analyzing financial data and transactions in order to model them into usable data.
Data mining is useful not only for making forecasts, but also for developing new services and goods.
Predictive models are used in the retail sector for products and services. Better quality and consumer insights are possible in retail stores. Historical data is used to calculate discounts and redemption.
Data mining aids financial gains and alerts for banks. They create a model based on consumer data that aids in the loan application process, among other things.
Customers gain confidence in companies, which leads to an increase in the number of clients.
Marketing firms use data mining to create data models and forecasts based on historical data. They manage promotions, marketing strategies, and so on. This leads to fast growth and prosperity.
Data mining results in the creation of new revenue sources, resulting in the expansion of the company.
Data mining aids in the improvement of strategy and decision-making processes in organizations.
When competitive advantages are found, data mining can help reduce production costs.
3.3 Data mining techniques and tasks
Understanding the types of tasks, or problems, that data mining can solve is the best way to learn about it. The majority of data mining tasks can be classified as either prediction or summary at a high level. Predictive tasks allow you to forecast the value of a variable based on previously collected data. Predicting when a customer will leave a business, predicting whether a transaction is fraudulent, and recognizing the best customers to receive direct marketing offers are all examples of predictive tasks. Descriptive tasks, on the other hand, attempt to summarize the information. Automatically segmenting customers based on their similarities and differences, as well as identifying correlations between products in market-basket data, are examples of such tasks [12].
Organizations now have more data at their disposal than they have ever had before. However, due to the sheer volume of data, making sense of the massive amounts of organized and unstructured data to enact organization-wide changes can be exceedingly difficult. This problem, if not properly handled, has the potential to reduce the value of all the data.
Data mining is the method by which businesses look for trends in data to gain insights that are important to their needs. Both business intelligence and data science need it. Organizations may use a variety of data mining strategies to transform raw data into actionable insights [13]. These range from cutting-edge artificial intelligence to the fundamentals of data planning, all of which are critical for getting the most out of data investments.
Cleansing and preparing data
Pattern Recognition
Classification
Association
Detection of Outliers
Clustering
Regression
Prediction
Sequential trends
Decision Trees
Statistical techniques
Visualization
Neural Networks
Data warehousing
Machine Learning and Artificial intelligence
Cleansing and preparing data
Cleaning and preparing data is a vital part of the data mining process. Raw data must be cleansed and formatted in order to be useful in various analytic approaches. Different elements of data modeling, transformation, data migration, ETL, ELT, data integration, and aggregation are used in data cleaning and planning. It’s a necessary step in determining the best use of data by understanding its basic features and attributes. Cleaning and preparing data has obvious business value. Data is either useless to an entity or inaccurate due to its accuracy if this first phase is not completed. Companies must be able to trust their data, analytics results, and the actions taken as a result of those findings. These measures are also needed for good data quality and data governance.
Pattern Recognition
A basic data mining technique is pattern recognition. It entails spotting and tracking trends or patterns in data in order to draw informed conclusions about business outcomes. When a company notices a pattern in sales data, for example, it has a reason to act. If it’s determined that a certain product sells better than others for a specific demographic, a company may use this information to develop similar goods or services, or simply better stock the original product for this demographic [14].
Classification
The various attributes associated with different types of data are analyzed using classification data mining techniques. Organizations may categorize or classify similar data after identifying the key characteristics of these data types. This is essential for recognizing personally identifiable information that organizations may wish to shield or redact from records, for example.
Association
The statistical technique of association is a data mining technique. It denotes that some data (or data-driven events) are linked to other data. It’s similar to the machine learning concept of co-occurrence, where the existence of one data-driven event indicates the probability of another. Correlation and association are two statistical concepts that are very similar. This means that data analysis reveals a connection between two data occurrences, such as the fact that hamburger purchases are often followed by French fries purchases.
Detecting of Outliers
Outlier detection is used to identify the deviations in datasets. When companies discover anomalies in their records, it becomes easier to understand why they occur and plan for potential events in order to achieve business goals. For example, if there is an increase in the use of transactional systems for credit cards at a certain time of day, businesses can use this information to maximize their income for the day by finding out the cause of it.
Clustering
Clustering is an analytics methodology that employs visual approaches to data interpretation. Graphics are used by clustering mechanisms to demonstrate where data distribution is in relation to various metrics. Different colors are used in clustering techniques to represent data distribution. When it comes to cluster analytics, graph-based methods are perfect. Users can visually see how data is distributed and recognize patterns related to their business goals using graphs and clustering in particular.
Regression
The essence of the relationship between variables in a dataset can be determined using regression techniques. In some cases, such connections may be causal, and in others, they may only be correlations. Regression is a simple white box technique for revealing the relationships between variables. In areas of forecasting and data modeling, regression methods are used (Figure 2).
Prediction
Figure 2.
Illustration example of linear regression on a set of data [15].
One of the four branches of analytics is prediction, which is a very important feature of data mining. Patterns observed in current or historical data are extended into the future using predictive analytics. As a result, it allows businesses to predict what data patterns will emerge next. Using predictive analytics can take a variety of forms. Machine learning and artificial intelligence are used in some of the more advanced examples. Predictive analytics, on the other hand, does not have to rely on these methods; simpler algorithms can also be used.
Sequential Trends
This data mining technique focuses on identifying a sequence of events. It’s particularly useful for transactional data mining. For example, when a customer buys a pair of shoes, this technique will show which pieces of clothing they are more likely to buy. Understanding sequential trends may assist businesses in recommending additional products to consumers in order to increase sales.
Decision trees
Decision trees are a form of predictive model that enables businesses to mine data more effectively. A decision tree is technically a machine learning technique, but because of its simplicity, it is more often referred to as a white box machine learning technique. Users can see how the data inputs influence the outputs using a decision tree. A random forest is a predictive analytics model that is created by combining different decision tree models. Complicated random forest models are referred to as “black box” machine learning techniques because their outputs are not always easy to comprehend based on their inputs. However, in most cases, this simple form of ensemble modeling is more effective than relying solely on decision trees (Figure 3).
Statistical techniques
Figure 3.
Example of a decision tree [15].
Statistical approaches are at the heart of the majority of data mining analytics. The various analytics models are focused on mathematical principles that produce numerical values that can be used to achieve clear business goals. In image recognition systems, neural networks, for example, use complex statistics based on various weights and measures to decide if a picture is a dog or a cat. Statistical models are one of artificial intelligence’s two primary branches. Some mathematical methods have static models, while others that use machine learning improve over time.
Visualization
Another essential aspect of data mining is data visualization which uses sensory impressions that can be seen to provide users with access to data. Today’s data visualizations are interactive, useful for streaming data in real-time, and distinguished by a variety of colors that show various data trends and patterns. Dashboards are a valuable tool for uncovering data mining insights using data visualizations. Instead of relying solely on the numerical results of mathematical models, organizations may create dashboards based on a variety of metrics and use visualizations to visually illustrate trends in data.
Neural Networks
A neural network is a type of machine learning model that is frequently used in AI and deep learning applications. Among the most accurate machine learning models used today is neural network. They are named for the fact that they have multiple layers that resemble how neurons function in the human brain. While a neural network can be a powerful tool in data mining, companies should exercise caution when using it because some of these neural network models are extremely complex, making it difficult to understand how a neural network calculated an output (Figure 4).
Data warehousing
Figure 4.
Example of a neural network [15].
Data warehousing used to imply storing organized data in relational database management systems so that it could be analyzed for business intelligence, reporting, and simple dashboarding. Cloud data centers and data warehouses in semi-structured and unstructured data stores, such as Hadoop, are available today. Although data warehouses have historically been used to store and analyze historical data, many new approaches can now provide in-depth, real-time data analysis.
Machine Learning and Artificial Intelligence
Some of the most advanced advances in data mining are machine learning and artificial intelligence (AI). When operating with large amounts of data, advanced machine learning techniques such as deep learning provide extremely accurate predictions. As a result, they can be used to process data in AI applications such as computer vision, speech recognition, and advanced text analytics using Natural Language Processing. These data mining techniques work well with semi-structured and unstructured data to determine meaning.
3.4 Data mining software for optimization
With so many methods to use during data mining, it’s important to have the right resources to get the most out of your analytics. For proper implementation, these methods usually necessitate the use of many different tools or a tool with a broad set of capabilities.
While organizations can use data science tools like R, Python, or Knime for machine learning analytics, it’s critical to use a data governance tool to ensure compliance and proper data lineage. Additionally, in order to conduct analytics, companies would need to collaborate with repositories such as cloud data stores, as well as dashboards and data visualizations to provide business users with the knowledge they need to comprehend analytics. All of these features are available in tools, but it’s critical to find one or more that meet your company’s requirements [16].
4. Discussions
4.1 The cloud and data mining’s future
The development of data mining has been accelerated by cloud computing technology. Cloud systems are ideally adapted for today’s high-speed, massive amounts of semi-structured and unstructured data that most businesses must contend with. The elastic capabilities of the cloud will easily scale to meet these big data demands. As a result, since the cloud can carry more data in a variety of formats, more data mining techniques are needed to transform the data into insight. Advanced data mining techniques such as AI and deep learning are now available as cloud services.
Future advancements in cloud computing would undoubtedly increase the need for more powerful data mining software. AI and machine learning will become even more commonplace in the next five years than they are now. The cloud is the most suitable way to both store and process data for business value, given the exponentially growing pace of data growth on a daily basis. As a result, data mining methods can depend much more on the cloud than they do now.
Currently, data scientists use a variety of data mining techniques, which differ in precision, efficiency, and the type and/or volume of data available for analysis. Classical and modern data mining techniques are two types of data mining techniques. Statistical approaches, Nearest Neighbors, Clustering, and Regression Analysis are examples of Classical techniques, while Modern techniques include Neural Networks, Rule Induction Systems, and Decision Trees.
4.2 Data mining techniques – advantages and disadvantages
Statistical Techniques
Advantages
Because secondary data is normally inexpensive and requires less time to compile because it has already been done.
Because the patterns and correlations are obvious and reliable.
Broad samples were used to ensure high generalizability.
It can be used several times to test various variables.
It is possible to assess changes that enhance reliability and representativeness.
Disadvantages
The researcher is only able to draw patterns and correlations from the data and cannot assess the validity or consider a causal theory process.
Statistical data is often secondary data, making misinterpretation simple.
Statistical evidence can be manipulated, and it can be skewed and phrased to support the researcher’s point (effects objectivity).
It’s difficult to view and validate this data because it’s always secondary.
Nearest Neighbors
Advantages
It’s easy and intuitive to use
It does not make any assumptions
No Education Transfer
It is constantly growing.
It is a simple multi-class issue to enforce.
Regression and classification are also possible applications.
Selecting the first hyper parameter can take some time, but once done, the rest of the parameters are compatible with it.
Provides a variety of distance parameters to choose from (Euclidean distance, Hamming distance, Manhattan distance, and Minkowski distance).
Disadvantages
Irrelevant characteristics can influence the distance between neighbors.
While the implementation can be simple, the efficiency (or speed of the algorithm) decreases rapidly as the dataset grows.
Can handle a small number of input variables, but as the number of variables increases, the algorithm has trouble predicting the performance of new data points.
Characteristics must be consistent.
When classifying new data, the problem of determining the optimal number of neighbors to consider is frequently encountered.
Issues with using data that is unbalanced.
It is vulnerable to outliers since neighbors are clearly selected based on distance parameters.
Clustering
Advantages
Hierarchical methods enable the end user to choose from a large number of clusters or a small number of clusters.
Appropriate for data sets of any form and attributes of any kind.
There are a variety of well-developed models that provide a way to accurately represent the data, and each model has its own unique characteristics that can provide significant advantages in some specific areas.
Disadvantages
Cluster numbers must be preset.
The assumption is not completely right, and the clustering result is dependent on the parameters of the chosen models.
Regression Analysis (MARS- Multivariate Analysis for Regression Splines, OLS - Ordinary Least Square regression, SVR-Support Vector Regression, Radial Basis Function Networks)
Advantages
Linear regression can solve some very simple problems much faster and more easily, since prediction is simply a multiple of the predictors.
Linear regression: the modeling process is simple, requires few calculations, and runs quickly even when the data is large.
Linear regression: the factor can provide insight into and interpretation of each variable.
In linearly separable datasets, linear regression works well.
Linear regression is easier to implement, evaluate, and apply than other methods.
In linear regression, dimensionality reduction, regularization (L1 and L2), and cross-validation methods can all be used to prevent over-fitting.
Multiple regression will assess the relative importance of one or more predictor variables in determining the criterion’s significance.
Outliers, or deviations, can be found using multiple regression.
Disadvantages
Linear regression: There is a minimum linear association.
Linear regression: Outliers are affected easily.
The regression solution would most likely be thick (because there is no regularization)
Linear regression is vulnerable to noise and overfitting.
Regression solutions obtained through a variety of approaches (e.g., optimization, less-square, QR decomposition, etc.) are not necessarily unique.
Vulnerable to multicollinearity: Multicollinearity should be eliminated (using dimensionality reduction techniques) before using linear regression since it means that the independent variables have no relationship.
Any disadvantage of using a multiple regression model is usually due to the data used, either because there is insufficient data or because the cause is incorrectly assumed to be a correlation.
Neural Networks
Advantages
Artificial Neural Networks (ANN) will model and analyze nonlinear, complex relationships.
Has highly accurate statistical models that can be used to solve a wide range of problems.
Information is stored on the network as a whole, not in a database, and the network will run even though a few pieces of information are missing from one location.
The ability to work with limited knowledge
Has fault tolerance, which means that contamination of one or more ANN cells will not stop development.
Is endowed with a memory.
Gradual corruption: As a network ages, it slows down and becomes more vulnerable. The network issue does not seem to be corroding right away.
Machine-training capability: Artificial neural networks learn events by observing and reflecting on similar events.
Parallel processing capability: Artificial neural networks have the computing capacity to perform several tasks at the same time.
Disadvantages
Extraction of features-the issue of determining which predictors are the most suitable and significant in building models that are predictably accurate.
Hardware reliance: Artificial neural networks, by their very nature, require parallel processing processors. This is the foundation on which the equipment realization is built.
Assurance of proper network structure: When it comes to artificial neural network design, there are no hard and fast rules. The correct network design is achieved by practice and trial and error.
Network behavior that is not explained: Even though ANN provides a sampling solution, it does not explain why or how it works.
Difficulty in demonstrating the problem to the network: ANNs should deal with numerical data. Before integrating into ANN, problems must be translated into numerical values.
The network’s length is unknown: reducing the network to a certain sample error value indicates that the training is complete. This may not result in optimal results.
Rule Induction
Advantages
When dealing with a small number of rules, IF-THEN rules are easy to understand and are meant to be the most interpretable model.
The decision rules are just as descriptive as decision trees, but they are a lot smaller.
Since only certain conditional statements must be checked to determine the rules apply, IF-THEN rules are simple to predict.
Since conditions only shift at the threshold, decision rules will withstand monotonous input function transformations.
IF-THEN rules produce models with few features. Only the features that are important to the model are chosen.
Simple rules like OneR can be used to test more complex algorithms.
Disadvantages
IF-THEN laws are mostly concerned with grouping and almost completely neglect regression.
Categorical functions are also needed. This means that numerical features must be classified if they are to be included.
The majority of older rule-learning algorithms are prone to overfitting.
In the study of linear feature-output relations, decision rules are ineffective.
Decision Trees (CART – Classification and Regression Trees)
Advantages
Data is organized into distinct categories, which are therefore simpler to grasp than points on a multidimensional hyperplane, as in linear regression. With its nodes and edges, the tree structure has a natural visualization.
In real-world problems, the models to be built and the interactions to be detected are usually much more complex.
CART validates the Tree immediately, implying that the algorithm has the model validation and discovery of the optimally general model (the algorithm) built deep inside it.
When it comes to missing data, the CART algorithm is fairly reliable.
There are so many powerful data mining features that decision trees mark so strongly.
Disadvantages
Can struggle with some very simple problems where prediction is simply a multiple of predictors.
Trees are incapable of handling linear relationships. Splits must be used to approximate any linear input–output relationship, resulting in a phase function. This is not going to work.
It had a silky feel to it. Small changes in the input function may have a big effect on the forecast outcome, which is not always a good thing.
The trees are still very shaky. A few tweaks to the training dataset will result in a completely different tree. Since every split is based on splitting the parent, this is the case.
These methods are best applied to particular tasks in order to achieve the best performance. The Table 1 below lists the data mining tasks and the techniques that can be used to complete them.
Data mining tasks and the methods used to accomplish them.
A business analyst’s dream is data warehousing. All of the data concerning the organization’s actions is centralized and accessible through a single set of analytical tools. A data warehouse system’s goal is to give decision-makers the accurate, timely data they need to make the best decisions possible. A relational database management system server serves as the central repository for informational data in the data warehouse architecture. The processing of operational data is kept distinct from the processing of data warehouse data.
The central information repository is surrounded by a number of critical components that work together to make the overall ecosystem functional, manageable, and available to both operational systems and end-user query and analysis tools. The warehouse’s raw data is often derived from operational applications. Data is cleansed and turned into an integrated structure and format when it enters the warehouse. Conversion, summarization, filtering, and condensing of data may all be part of the transformation process. Since the data contains a historical component, the warehouse must be capable of holding and managing large volumes of data as well as different data structures for the same database over time.
The following Table 2 lists data mining techniques and their areas of applications.
Data mining techniques
Areas of use
Association Analysis
Designing store shelves, marketing, cross-selling of products.
Classification (K-nearest neighbor, etc.)
Banks, marketing campaign designs by organizations.
Decision Trees
Medicine, engineering, manufacturing, and astronomy, to name a few fields. They were used to solve problems ranging from credit card depletion estimation to time series exchange rate estimation for a variety of international currencies.
Clustering Analysis
Image recognition, web search, and security.
Outlier Detection
Detection of credit card fraud risks, novelty detection, etc.
Regression Analysis (K-nearest neighbor, …)
Marketing and Product Development Efforts comparison.
Artificial Neural networks
Data compression, feature extraction, clustering, prototype formation, function approximation or regression analysis (including prediction time series, fitness approximation, and modeling), classification (including pattern and sequence recognition, novelty detection, and sequential decision making), data processing (including filtering, clustering, blind source separation, and compression), and robotic compression.
Support vector machines regression
Oil and gas industry, classification of images and text and hypertext categorization.
Multivariate Regression algorithm
Retail sector
Linear Regression
Financial portfolio prediction, salary forecasting, real estate predictions and in traffic estimated time of arrivals (ETAs).
Table 2.
Data mining techniques and their areas use.
5. Conclusion
It’s worthy of note to state that time is spent on extracting useful information from data. As a result, in order for companies to develop quickly, it is necessary to make accurate and timely decisions that enable them to take advantage of available opportunities. In today’s world of technology trends, data mining is a rapidly growing industry. In order to obtain valuable and reliable information, everyone today needs data to be used in the right way and with the right approach. Data mining can be initiated by gaining access to the appropriate resources. Since data mining begins immediately after data ingestion, finding data preparation tools that support the various data structures required for data mining analytics is important. Organizations may also want to identify data in order to use the aforementioned methods to explore it. Modern data warehousing, as well as various predictive and machine learning/AI techniques, are helpful in this regard.
Choosing which approach to employ, and when, is clearly one of the most difficult aspects of implementing a data mining process. Some of the parameters that are critical in deciding the technique to be used are determined by trial and error. There are clear differences in the types of problems that each data mining technique is best suited for. As a result, there is no simple rule that favors one technique over another. Decisions are often taken based on the availability of qualified data mining analysts in one or more techniques. The choice of a technique over the other is more dependent on the availability of good resources and analysts.
Acknowledgments
This work was supported by the Faculty of Applied Informatics, Tomas Bata University in Zlín, Czech Republic, under Projects IGA/CebiaTech/2021/001.
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This paper provides an overview of the data mining process, as well as its benefits and drawbacks, as well as data mining methodologies and tasks. This study also discusses data mining techniques in terms of their features, benefits, drawbacks, and application areas.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/78106",risUrl:"/chapter/ris/78106",signatures:"Julius Olufemi Ogunleye",book:{id:"10859",type:"book",title:"Data Mining",subtitle:"Concepts and Applications",fullTitle:"Data Mining - Concepts and Applications",slug:"data-mining-concepts-and-applications",publishedDate:"March 30th 2022",bookSignature:"Ciza Thomas",coverURL:"https://cdn.intechopen.com/books/images_new/10859.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-267-3",printIsbn:"978-1-83969-266-6",pdfIsbn:"978-1-83969-268-0",isAvailableForWebshopOrdering:!0,editors:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"354954",title:"Ph.D. Student",name:"Julius",middleName:null,surname:"Olufemi Ogunleye",fullName:"Julius Olufemi Ogunleye",slug:"julius-olufemi-ogunleye",email:"juliusolufemi@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Data Mining",level:"2"},{id:"sec_2_2",title:"1.2 The importance of data mining",level:"2"},{id:"sec_4",title:"2. Related works",level:"1"},{id:"sec_4_2",title:"2.1 An overview of efficient data mining techniques",level:"2"},{id:"sec_5_2",title:"2.2 An overview of data mining techniques",level:"2"},{id:"sec_7",title:"3. Methods",level:"1"},{id:"sec_7_2",title:"3.1 Data mining process",level:"2"},{id:"sec_8_2",title:"3.2 Advantages of data mining",level:"2"},{id:"sec_9_2",title:"3.3 Data mining techniques and tasks",level:"2"},{id:"sec_10_2",title:"3.4 Data mining software for optimization",level:"2"},{id:"sec_12",title:"4. Discussions",level:"1"},{id:"sec_12_2",title:"4.1 The cloud and data mining’s future",level:"2"},{id:"sec_13_2",title:"4.2 Data mining techniques – advantages and disadvantages",level:"2"},{id:"sec_15",title:"5. Conclusion",level:"1"},{id:"sec_16",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Software Testing Help (April 16, 2020): Data Mining Techniques: Algorithm, Methods & Top Data Mining Tools'},{id:"B2",body:'Silhavy, P., Silhavy, R., & Prokopova, Z. (2019): Categorical variable segmentation model for software development effort estimation. IEEE Access, 7, 9618-9626'},{id:"B3",body:'Sandeep Dhawan (2014): An Overview of Efficient Data Mining Techniques'},{id:"B4",body:'Alex Berson et al. (2005): An Overview of Data Mining Techniques'},{id:"B5",body:'Jiawei H. and Micheline K. (2000): Data Mining: Concepts and Techniques'},{id:"B6",body:'ACM SIGKDD (2006-04-30), Retrieved (2014-01-27): Data Mining Curriculum'},{id:"B7",body:'Kamber H. Et al. (2011): Data Mining: Concepts and Techniques (3rd ed.). Morgan Kaufmann. ISBN 978-0-12-381479-1'},{id:"B8",body:'Clifton C. (2010): Encyclopædia Britannica: Definition of Data Mining”. Retrieved 2010-12-09'},{id:"B9",body:'Weiss G. M. and Davison B. D. (2010): Data Mining (Handbook of Technology Management, H. Bidgoli (Ed.), John Wiley and Sons, 2010)'},{id:"B10",body:'Mehmed K. (2011): Data Mining Concepts, Models, Methods, and Algorithms (Second Edition)'},{id:"B11",body:'Berson A. et.al (2005): An Overview of Data Mining Techniques (Excerpts from the book by Alex Berson, Stephen Smith, and Kurt Thearling)'},{id:"B12",body:'Karna H. et al. (2018): Application of data mining methods for effort estimation of software projects'},{id:"B13",body:'Sehra S.K. et al. (2014): Analysis of Data Mining techniques for software effort estimation'},{id:"B14",body:'Trevor H. Et al.(2009): The Elements of Statistical Learning: Data Mining, Inference, and Prediction. Archived from the original on 2009-11-10. Retrieved 2012-08-07'},{id:"B15",body:'Ogunleye J.O. (2020): Review of Data Mining Techniques in Software Effort Estimation'},{id:"B16",body:'Dejaeger K., et al.(2012): Data Mining Techniques for Software Effort Estimation: A Comparative Study'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Julius Olufemi Ogunleye",address:"juliusolufemi@yahoo.com",affiliation:'
Tomas Bata University in Zlin, Zlín, Czech Republic
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One major complication of this procedure is adjacent segment degeneration. Cervical disc arthroplasty (CDA) has been proposed as an alternative to ACDF and as a means to reduce ASD. This chapter briefly recounts the advent of CDA. Additionally, it describes the most common implants and biomechanical properties associated with those designs. Critical to CDA is meticulous operative technique including implant positioning and hemostasis. Data in the form of FDA IDE studies and more recent meta-analyses of existing studies have demonstrated non-inferiority of CDA when compared to ACDF. This chapter also reviews the most common complications associated with CDA including heterotopic ossification and ankylosis of the involved segment. While more technically demanding than ACDF, CDA does represent a viable alternative in the proper patient.",signatures:"Christopher Paul O’Boynick and Bruce V. Darden II",authors:[{id:"74274",title:"Dr.",name:"Bruce V.",surname:"Darden",fullName:"Bruce V. 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Sonar, MS in Orthopaedics, practises sports medicine and shoulder surgery in Nagpur, India. He is an associate professor in the Department of Orthopaedics at the Dr. PDM Medical College, Amravati, Maharashtra, India. Dr. Sonar is an executive committee member of the Shoulder and Elbow Society of India and serves as a team physician for various local, collegiate and professional sports teams. Dr. Satish B. Sonar is the secretary of Nagpur Arthroscopy Society, and every year he organizes ‘Nagpur Arthroscopy Meet’, a 2-day conference covering recent advances in arthroscopy and sports medicine with lectures, debates, discussions, video demonstrations and live surgeries. He is the founder and director of ‘Sports Med Joint Care Centre’ in Nagpur, exclusively managing sports injuries, shoulder surgeries and arthroscopy. Dr. Sonar has participated in many national conferences and courses over the years. He has many presentations and publications to his name.",institutionString:"Mumbai University",institution:{name:"University of Mumbai",institutionURL:null,country:{name:"India"}}},{id:"174019",title:"Dr.",name:"Ülle",surname:"Voog-Oras",slug:"ulle-voog-oras",fullName:"Ülle Voog-Oras",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"176440",title:"Dr.",name:"Mohamad",surname:"Qoreishy",slug:"mohamad-qoreishy",fullName:"Mohamad Qoreishy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"customer-complaints",title:"Customer Complaints",intro:'
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Receipt of complaints will be acknowledged in writing and Intech Limited will respond fully to concerns within 15 business days.
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Customers have the right to terminate the contract without giving any reason (written notice of termination). The deadline for said termination is fourteen (14) days from the date of receipt of goods. Returns are at the expense of the Customer and must be made within the fourteen (14) days from the date of the written notice of termination. Intech Limited will process refunds to the Customer without undue delay.
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In the event that the Publisher ships damaged or misbound copies of products, or duplicate or incorrect copies of the products are received by the Customer, the Publisher will accept returns at the Publisher's expense, provided notice of such damaged or incorrect shipment is given to the Publisher within fourteen (14) working days from the date of receipt.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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From Old Problems to New Challenges"},signatures:"Andreas Schmeling, Pedro Manuel Garamendi, Jose Luis Prieto and María Irene Landa",authors:[{id:"34264",title:"Prof.",name:"Pedro Manuel",middleName:null,surname:"Garamendi Gonzalez",slug:"pedro-manuel-garamendi-gonzalez",fullName:"Pedro Manuel Garamendi Gonzalez"}]},{id:"19161",doi:"10.5772/19234",title:"Diagnostic of Drowning in Forensic Medicine",slug:"diagnostic-of-drowning-in-forensic-medicine",totalDownloads:8196,totalCrossrefCites:9,totalDimensionsCites:18,abstract:null,book:{id:"243",slug:"forensic-medicine-from-old-problems-to-new-challenges",title:"Forensic Medicine",fullTitle:"Forensic Medicine - From Old Problems to New Challenges"},signatures:"Audrey Farrugia and Bertrand Ludes",authors:[{id:"34146",title:"Dr.",name:"Audrey",middleName:null,surname:"Farrugia",slug:"audrey-farrugia",fullName:"Audrey Farrugia"},{id:"49284",title:"Dr.",name:"Bertrand",middleName:null,surname:"Ludes",slug:"bertrand-ludes",fullName:"Bertrand Ludes"}]},{id:"19172",doi:"10.5772/22792",title:"Advanced Medical Imaging and Reverse Engineering Technologies in Craniometric Study",slug:"advanced-medical-imaging-and-reverse-engineering-technologies-in-craniometric-study",totalDownloads:4535,totalCrossrefCites:2,totalDimensionsCites:6,abstract:null,book:{id:"243",slug:"forensic-medicine-from-old-problems-to-new-challenges",title:"Forensic Medicine",fullTitle:"Forensic Medicine - 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These include situation of death, anatomical and histological analysis, toxicology and microbiological study. A low part of autopsies remain without a conclusive cause of death, but all these cases are usually seen in young population, apparently healthy who died suddenly and unexpectedly. In these situations a cardiac arrhythmia is suspected as cause of death and genetic testing is recommended despite not regularly performed. Sudden death is a natural and unexpected decease that occurs in apparently healthy people, or whose disease was not severe enough to expect a fatal outcome. It can be due to several pathologies, usually of cardiac cause and called sudden cardiac death. In infants and young people, both long QT syndrome and catecholaminergic polymorphic ventricular tachycardia are main causes in negative autopsies. These genetic diseases lead to ventricular fibrillation, syncope and sudden cardiac death in a normal heart. Unfortunately, sudden cardiac death could be the first manifestation of the diseases, being early identification and prevention a crucial point in current medical practice. This chapter focuses on sudden death and negative autopsy in young population, mainly due to cardiac arrhythmias.",book:{id:"6262",slug:"post-mortem-examination-and-autopsy-current-issues-from-death-to-laboratory-analysis",title:"Post Mortem Examination and Autopsy",fullTitle:"Post Mortem Examination and Autopsy - Current Issues From Death to Laboratory Analysis"},signatures:"Georgia Sarquella-Brugada, Sergi Cesar, Anna Fernandez-Falgueras,\nMaria Dolores Zambrano, Anna Iglesias, Josep Brugada, Ramon\nBrugada and Oscar Campuzano",authors:[{id:"54165",title:"Prof.",name:"Ramon",middleName:null,surname:"Brugada",slug:"ramon-brugada",fullName:"Ramon Brugada"},{id:"54168",title:"Dr.",name:"Oscar",middleName:null,surname:"Campuzano",slug:"oscar-campuzano",fullName:"Oscar Campuzano"},{id:"218478",title:"Dr.",name:"Georgia",middleName:null,surname:"Sarquella-Brugada",slug:"georgia-sarquella-brugada",fullName:"Georgia Sarquella-Brugada"},{id:"218479",title:"Dr.",name:"Sergi",middleName:null,surname:"Cesar",slug:"sergi-cesar",fullName:"Sergi Cesar"},{id:"218480",title:"MSc.",name:"Anna",middleName:null,surname:"Fernandez-Falgueras",slug:"anna-fernandez-falgueras",fullName:"Anna Fernandez-Falgueras"},{id:"218482",title:"Dr.",name:"Maria Dolores",middleName:null,surname:"Zambrano",slug:"maria-dolores-zambrano",fullName:"Maria Dolores Zambrano"},{id:"218483",title:"MSc.",name:"Anna",middleName:null,surname:"Iglesias",slug:"anna-iglesias",fullName:"Anna Iglesias"},{id:"218484",title:"Prof.",name:"Josep",middleName:null,surname:"Brugada",slug:"josep-brugada",fullName:"Josep Brugada"}]},{id:"57778",title:"Defining Dental Age for Chronological Age Determination",slug:"defining-dental-age-for-chronological-age-determination",totalDownloads:2574,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Dental age assessment is one of the most reliable methods of chronological age estimation used for criminal, forensic and anthropologic purposes. Visual, radiographic, chemical and histological techniques can be used for dental age estimation. Visual method is based on the sequence of eruption of the teeth and morphological changes that are caused due to function such as attrition, changes in color that are indicators of aging. Radiographs of the dentition can be used to determine the stage of dental development of the teeth from initial mineralization of a tooth, crown formation to root apex maturation. Histological methods require the preparation of the tissues for detailed microscopic examination. The chemical analysis of dental hard tissues determines alterations in ion levels with age, whereas the histological and chemical methods are invasive methods requiring extraction/sectioning of the tooth. In this chapter, the different techniques and considered studies were overviewed in conjunction with their advantages and disadvantages. It needs to be taken into consideration that rather than restricting on one age estimation technique, using the other available techniques additionally and performing repetitive measurements may be beneficial for accurate age estimation.",book:{id:"6262",slug:"post-mortem-examination-and-autopsy-current-issues-from-death-to-laboratory-analysis",title:"Post Mortem Examination and Autopsy",fullTitle:"Post Mortem Examination and Autopsy - Current Issues From Death to Laboratory Analysis"},signatures:"Fatma Deniz Uzuner, Emine Kaygısız and Nilüfer Darendeliler",authors:[{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner"},{id:"200985",title:"Dr.",name:"Emine",middleName:null,surname:"Kaygisiz",slug:"emine-kaygisiz",fullName:"Emine Kaygisiz"},{id:"222232",title:"Prof.",name:"Nilufer",middleName:null,surname:"Darendeliler",slug:"nilufer-darendeliler",fullName:"Nilufer Darendeliler"}]},{id:"77222",title:"Forensic Analysis and Interpretation of Tool Marks",slug:"forensic-analysis-and-interpretation-of-tool-marks",totalDownloads:492,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The forensic analysis and interpretation of tool marks raise for consideration key methods and advances in the field of tool marks in forensic science. This chapter shows how tool mark analysis can be utilized in the course of criminal investigations. The focus of the chapter is on bringing together as much scientific knowledge in the area as possible in an accessible manner. It covers all aspects of tool mark evidence from the crime scene to the courtroom. This chapter provides information about tool marks in an effort to assist tool mark examiners as well as people practicing forensic science, crime scene examiners, crime investigating officers and members of the legal profession. 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\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
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\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
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His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. Prof. Navarro-Pedreño is also a director of the Ph.D. Program Environment and Sustainability (2012-present) and a member of several societies among which are the Spanish Society of Soil Science, International Union of Soil Sciences, European Society for Soil Conservation, DessertNet and the Spanish Royal Society of Chemistry.",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",slug:"elke-jurandy-bran-nogueira-cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",slug:"sandra-ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:14,paginationItems:[{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80954",title:"Ion Channels and Neurodegenerative Disease Aging Related",doi:"10.5772/intechopen.103074",signatures:"Marika Cordaro, Salvatore Cuzzocrea and Rosanna Di Paola",slug:"ion-channels-and-neurodegenerative-disease-aging-related",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. 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\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation"},{id:"39",title:"Environmental Resilience and Management",scope:"
\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
\r\n\tWater is not only a crucial substance needed for biological life on Earth, but it is also a basic requirement for the existence and development of the human society. Owing to the importance of water to life on Earth, early researchers conducted numerous studies and analyses on the liquid form of water from the perspectives of chemistry, physics, earth science, and biology, and concluded that Earth is a "water polo". Water covers approximately 71% of Earth's surface. However, 97.2% of this water is seawater, 21.5% is icebergs and glaciers, and only 0.65% is freshwater that can be used directly by humans. As a result, the amount of water reserves available for human consumption is limited. The development, utilization, and protection of freshwater resources has become the focus of water science research for the continued improvement of human livelihoods and society.
\r\n
\r\n\tWater exists as solid, liquid, and gas within Earth’s atmosphere, lithosphere, and biosphere. Liquid water is used for a variety of purposes besides drinking, including power generation, ecology, landscaping, and shipping. Because water is involved in various environmental hydrological processes as well as numerous aspects of the economy and human society, the study of various phenomena in the hydrosphere, the laws governing their occurrence and development, the relationship between the hydrosphere and other spheres of Earth, and the relationship between water and social development, are all part of water science. Knowledge systems for water science are improving continuously. Water science has become a specialized field concerned with the identification of its physical, chemical, and biological properties. In addition, it reveals the laws of water distribution, movement, and circulation, and proposes methods and tools for water development, utilization, planning, management, and protection. Currently, the field of water science covers research related to topics such as hydrology, water resources and water environment. It also includes research on water related issues such as safety, engineering, economy, law, culture, information, and education.
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Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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