Jeane Visentainer

By Daniela Maira Cardozo, Amanda Vansan Marangon, Ana Maria Sell, Jeane Eliete Laguila Visentainer and Carmino Antonio de Souza

Part of the book: HLA and Associated Important Diseases

By Ana Maria Sell, Josiane Bazzo de Alencar, Jeane Eliete Laguila Visentainer and Cleverson de Oliveira e Silva

Periodontitis is a chronic inflammatory condition characterized by destruction of non-mineralized and mineralized connective tissues. The pathogenesis of periodontitis involves a complex interplay between periodontopathogens and the host immunity, greatly influenced by genetic and environmental factors. Failure in the inflammation resolving mechanism leads to establishment of a chronic inflammatory process, resulting in the progressive destruction of bone and soft tissue. The aim of this chapter is to summarize the role of innate and specific immune response involved in pathogenesis of periodontitis. Cells and inflammatory mediators, those participating in inflammatory process of the ligamentous supporting structure and in resorption of alveolar bone, will be presented.

Part of the book: Periodontitis

By Hugo Vicentin Alves, Bruna Tiaki Tiyo, Ana Maria Sell and Jeane Eliete Laguila Visentainer

Several genetic polymorphisms in immune response genes have been associated to leprosy. This fact converges on the main hypothesis that genetic factors are involved in the disease susceptibility in two distinct steps: leprosy per se and their clinical forms. These genes play an important role in the recognition process, in the activation of the main metabolic pathway of the immune response and in the evolution of the disease. The scope of this project was to highlight the role of the immune response genes in the context of leprosy, emphasizing the participation of some of them in the signaling and targeting processes in response to bacillus infection and on disease evolution, such as HLA, KIR and MIC genes. Some environmental and genetic factors are important when the exposure to the bacillus occurs, leading to cure or not. Factors that favor a cellular or humoral immune response may influence the clinical manifestations after the infection inducting to one of extreme poles. Furthermore, some genetic factors were associated to the type of reaction that some individuals present during the disease development. Thus, it is very important to highlight the participation of some genetic factors in the immunopathogenesis of leprosy.

Part of the book: Hansen's Disease

By Jesui Vergilio Visentainer, Oscar Oliveira Santos, Liane Maldaner, Caroline Zappielo, Vanessa Neia, Lorena Visentainer, Luciana Pelissari, Jessica Pizzo, Adriela Rydlewski, Roberta Silveira, Marilia Galuch and Jeane Laguila Visentainer

Human milk is related to the physiological and nutritional welfare of newborns, providing the necessary dietary energy, physiologically active compounds and essential nutrients for breastfed babies. Human milk fat has an important position as energy source, structural and regulatory functions, being one of the most important components of breast milk. It provides approximately 50–60% of the energy of the human milk, and its composition in fatty acids defines its nutritional and physico-chemical properties. Furthermore, human milk contains the long-chain polyunsaturated essential fatty acids (LCPUFA) eicosapentaenoic acid (EPA), arachidonic acid (AA) and docosahexaenoic acid (DHA), which is important for appropriate development of baby’s organs, tissues and nervous system. This chapter will address the benefits associated with the consumption of human milk (health, nutritional, immunological and developmental benefits) as well as the analysis applied to determine the lipid quality of this powerful food.

Part of the book: Biochemistry and Health Benefits of Fatty Acids