Desalination processes [16]
\r\n\tThe WHO classification in 2007; was based on the histogenesis and cell origin of the tumor. In the latest classification made in 2016; to better characterize the tumor and obtain better data on its prognosis; The combination of molecular and genetic biomarkers and histopathological features of the tumor was used. Despite all current treatment approaches, the median survival time is around 12 months in most GBM patients. Compared with the situation of some types of successfully treated cancers; the survival time of GBM patients is not at an acceptable level today. In the treatment of CNS tumors; surgery, chemotherapy, and radiation treatments (x-rays, gamma rays, electron and proton beams) are used. The therapeutic potential of chemotherapy; New strategies are needed to increase drug concentration at the diseased site, as this largely depends on the ability of the chemotherapeutic agent to achieve effective concentrations at tumor localization. Based on our better understanding of the genetic and molecular characteristics of CNS tumors; Targeted therapies, including vaccines, and treatment protocols such as immunotherapy are promising developments.
\r\n\r\n\tThis book supposes to be written by many authors who have an internationally honored place in their field to share their ideas about the treatment of CNS tumors. Surgery, Radiotherapy, Chemotherapy and Antiangiogenic Therapy Protocols, Immunotherapy, Molecular Therapy, Specific target-agents therapy with Nanoparticles and Gene Therapy for CNS tumors among the book chapters.
\r\n\tIn these sections; there are many practical pieces of information that can help the students who graduated from the Medicine Faculty and specialist doctors who are interested in Neurosurgery.
Freshwater and energy are two inseparable and essential commodities for sustaining human life on earth. Rapid population growth and industrialization, especially in developing countries in the recent past, have placed pressing demands for both freshwater and energy [1]. Both are to be conserved and preserved for the sustainable development of the world. On the other hand, there is an acute shortage of both energy and water, especially in the third world countries [2]. Only less than 1% of the water is available for the society for direct use, out of which the maximum fraction has been polluted due to non-manageable industrial developments [2].
Due to the fast increase in the world population, the need for the energy increases rapidly. Various studies have been made to meet this extra energy demand. Most of these studies were focused on alternative energy sources. Solar energy is one of the most popular ones of these sources due to relatively less installation cost and long operation time without any need for maintenance [3]. Basically, all forms of the energy in the world, as we know it, are solar in origin. Oil, coal and natural gas is originally produced by photosynthetic processes, followed by complex chemical reactions, in which decaying vegetation was subjected to temperature and pressure over a long period of time [4].
Solar energy is so powerful and abundant that 30 min of solar radiation falling on earth is equal to the world annual energy demand. It is also cheap, environment friendly and nearly inexhaustible. Most of the world receives powerful solar radiation and has a good chance and opportunity to benefit from solar energy [3].
All ecosystems and every field of human activity depend on clean water and it is one of the most precious resources in today’s world. Water is a primary need for life, health and sanitation, which brings it into the international agenda as a very important issue [2]. The lack of potable water poses a big problem in arid regions of the world where freshwater is becoming very scarce and expensive. Clean drinking water is one of the most important international health issues today [5]. Remote and arid to semi-arid regions depend on underground water for drinking. Unfortunately, underground water is not always considered to be fresh drinking water. In some instances, the salinity is too high for being drinkable, and it is called brackish water. In such cases, fresh water has to be either transported for long distances or connected with an expensive distribution water network at extremely high cost for, usually, a small population. Solar desalination can be a good solution for such a problem [6].
Desalination is one of mankind’s earliest forms of water treatment, and it is still a popular treatment solution throughout the world today [5]. Distillation is one of the oldest and most rustic desalination techniques. In fact, it reproduces the natural process of the industrial desalination. Solar distillation is a thermal process that represents a sustainable solution to water shortages in the world. The desalination technique by solar energy, based on the principle of greenhouse is not new. Solar energy coupled to desalination offers a promising prospect for covering the fundamental needs of power and water in remote regions, where connection to the public electric grid is either not cost effective or not feasible, and where the water scarcity is severe [5].
The earth has a global water amount of about 1
The water cycle is caused by solar energy which heats the water in oceans, seas, lakes, rivers and lands containing moisture. Water evaporates and becomes water vapour while ice, hail and snow can transit from solid to vapour phase directly which is called sublimation. An average of 16 million m3 of water is evaporated every second and then the vapour is transported in the atmosphere to where it comes across cooler temperatures which will eventually cause the vapour to condense and precipitate as rain, sleet, snow or hail. Nearly, four-fifth of the evaporated vapour falls back into the oceans and some other flows through the ground surface to the sea. Some water also goes deep into the ground layers and fills aquifers, which are the long-term water storages. Some groundwater comes out as springs through openings in the ground. Eventually, the water returns to the ocean and joins to the water cycle again. Figure 1 shows a schematic illustration of the water cycle (This Figure adapted from http://www.srh.noaa.gov/jetstream/atmos/hydro.htm).
The global water cycle (the units are in 103 km3. year−1) [
Due to wind regimes and atmospheric conditions, water vapour and rain are not evenly distributed throughout all the earth land. Therefore some parts of the earth take much more precipitation than the others. This situation causes a failure to provide enough usable water for everyone living in a certain region which can be caused by mainly two reasons. If the water in that region is physically less than the amount of water required in order to meet the demands of people in that region for drinking, home use and agriculture, this situation is called “physical water scarcity”. On the other hand, if the water resources are present but they are not effectively used due to lack of investment or absence of qualified personnel or just administrations to process the water to provide people with the water they need, it is called “economic water scarcity” [8].
Although all parts of the earth is exposed to solar radiation throughout a year, the equator zone between 35°N and 35°S latitudes receives much more solar energy compared to the other parts of the earth and is called “Sunbelt region” [10]. About four-fifth of the world population lives in this region. Having abundant solar energy on one side, the Sunbelt region countries experience a serious water scarcity problem. This scarcity is not only physical water scarcity, indeed it is an economic water scarcity especially in Africa, which means lack of investment in water infrastructure or the lack of personnel capacity to adequately meet the drinking and irrigation water demand of the population. Figure 2 shows a schematic illustration of the Sunbelt region and global water scarcity in the world.
Global physical and economic water scarcity and Sunbelt region [
One of the vital factors in combatting the economic water scarcity is a cheap, clean, affordable and environment friendly energy source which will be used to produce and distribute usable and drinkable water. Renewable energy sources such as; solar, wind, geothermal, biomass, etc. is suitable for this purpose.
Sunbelt region is very suitable to use solar energy, which is a very popular and abundant energy source, to produce fresh water from saline water through a number of desalination methods, which will be discussed in detail later. 6 kWh/(m2.d) of solar energy, which is easily reached in Sunbelt region, is equal to 0.6 l/m2.d and 220 l/m2.y of oil. Therefore it is practically possible to use solar energy instead of especially fossil fuels in this region [12].
Total fresh water consumption in the world can be classified into three categories; about 70% is used for irrigation, 20% is used for industrial purposes, and only 10% of the fresh water is consumed for domestic uses as drinking and cleaning water. In case of a shortage of fresh water, desalination is a way to produce usable and drinkable fresh water from any source of saline water to meet the demand.
Desalination is the process of separating salt from saline water, which is a mixture of pure water and salt, in order to obtain fresh water. Water salinity due to dissolved salts can be expressed in four classes as; fresh water (<0.05%salinity), brackish water (0.05–3% salinity), saline water (3–5% salinity) and brine (>5% salinity) [13]. The most important property of the desalinized water and thus the parameter observed through the process is salinity. Salinity can be expressed in particles per million (ppm) or salt mass fraction (
Although about two-third of the feed water for desalination process is the sea water, waste water (about 6%), river water (about 8%) and brackish water (about 19%) are also used as desalination water especially at places distant from the sea [14]. Actually, feed water with low salt concentration is preferable for the stills, where available, since it causes less contamination and scale formation in the system. The installed capacity of desalinated water system in year 2000 was about 22 million m3/day and has drastically increased to 71.7 million m3/day by the year 2010. It can be estimated that 71.7 million m3/day desalination requires about 650 million tons of oil/year as energy source [15].
This means that; using renewable energy sources in desalination processes instead of fossil fuels, a significant amount of pollution, greenhouse gas and global warming contribution can be avoided. Desalination process is mainly of two types: phase-changing processes and single-phase processes (Table 1). In addition to these two types of desalination, there are hybrid processes that employ both phase change and separation at the same time. Hybrid systems may be comprised of one unit in which both phase change and separation steps take place or they may have two units for two steps. Reverse osmosis combined with MSF or MED are two examples for hybrid process.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
1. Multi-stage flash (MSF) | \n\t\t\t1. Reverse osmosis (RO) – RO without energy recovery – RO with energy recovery (ER-RO) | \n\t\t
2. Multiple effect distillation (MED) | \n\t\t\t2. Electrodialysis (ED) | \n\t\t
3. Vapour compression (VC) | \n\t\t\t\n\t\t |
4. Freezing | \n\t\t\t\n\t\t |
5. Humidification/dehumidification | \n\t\t\t\n\t\t |
6. Solar stills – Conventional stills – Special stills – Cascaded type solar stills – Wick-type stills – Multiple-wick-type stills | \n\t\t\t\n\t\t |
Desalination processes [16]
Since changing the phase of saline water requires considerable amount of heat, solar energy is a very practical and readily available energy source along with geothermal and wind energy where available. Solar energy, wind energy and geothermal energy are used in renewable energy powered desalination plants with the percentages of 42%, 37% and 21% respectively. Solar power is used as both thermal energy and electricity through photo-voltaic panels.
Energy is the most vital need for living. Obtaining the usable forms of energy may cause both economic and environmental problems. Especially the fossil fuels have relatively high costs and environmental impacts which inevitably lead to seek for developing alternative methods. Using renewable energy sources is a good way to cope with energy and environmental problems. Renewable energy sources can easily replace fossil-fuels in the near future especially in stationary plants. Depleting reserves of fossil-fuels and environmental problems make it necessary to use the reserves more carefully. Solar energy has great potential in space heating for buildings owing to its low-grade energy characteristics and is the most important alternative to fossil fuels. Solar systems with feasible design and installation have very short payback periods and meet the energy demand very effectively.
Solar energy is widely used for drying, cooking, distillation, hot water and electricity production which are the very daily life needs of the people. Several methods using solar energy can be used easily to produce potable water from salt water to save people and agriculture from water scarcity. Main requirement of desalination process is thermal energy, and it can be provided through thermal and PV applications of solar energy systems. This energy can be integrated with various types of structure and capacity distillation systems to produce fresh water.
Salt gradient solar pond (SGSP) is a low cost method of capturing and storing solar energy at relatively low temperatures. A SGSP has mainly three layers of water filled in a pond in an order of salinity and relative mass from the bottom to the top.
The first and deepest layer of the pond is filled with a very salty water (about 20%), which is called Lower Convective Zone (LCZ). This layer is salty as much as possible to increase the relative mass of the water compared to the next upper layer which is called Non-Convective Layer (NCZ). This is accomplished by gravitational force that traps the water which takes the heat from the solar radiation and from the bottom of the pond, which absorbs the insolation passing through the transparent all UCZ, NCZ and LCZ layers, and tries to go upwards into the NCZ following normal convection process. Since NCZ layer has a relatively light water, convection process is suppressed and inhibited by the gravity of the LCZ water. Thus a transparent convective insulation is formed by the NCZ layer.
NCZ layer is structured as multilayer with a salinity gradient from bottom to top in order to slow down convective heat transfer to the upward direction. Slices of water layers with decreasing salinity provide insulation for the heat trapped in LCZ by eliminating convection between the NCZ layers.
UCZ is the top water layer of the pond with lowest salinity. UCZ layer is at near ambient temperature. It should be kept thin (about 30 cm) and should be protected from fluctuations caused by wind and wave which leads to mixing of NCZ and UCZ. Wind barriers or mash type covers can be used for big applications.
Solar ponds can provide thermal energy for domestic heating for space and water or power generation and desalination processes. The heat from a solar pond can be used in a Rankine cycle to produce mechanical energy and electricity. Figure 3 illustrates the structure and average heat losses to the ground and atmosphere.
Cross section of the salt gradient solar pond [
A heat pipe is essentially a passive heat transfer device with an extremely high effective thermal conductivity which allows a two-phase heat transfer mechanism resulting in enormous heat transfer capabilities nearly one thousand times that of an equivalent copper piece. The heat pipe in its simplest configuration is a closed, evacuated cylindrical vessel with the internal walls lined with a capillary structure called wick that is saturated with a working fluid.
A heat pipe has three regions namely; evaporator, condenser and adiabatic region. Heat is absorbed through the evaporator part of the heat pipe and transferred into the working fluid to vaporize some fluid. Vaporizing fluid pushes the vapour above towards the condenser part which is always above the evaporator region. The latent heat of evaporation contained in the vapour is transferred to the relatively cold surface of condenser causing the vapour to condensate on the surface of the condenser covered by a porous liner called wick, which serves as a passive pump to draw the fluid back to the evaporator by capillary effect. Then the heat is provided by the condenser to a fluid or gas through its surface. The middle section of heat pipe is called adiabatic region in which vapour travel from the evaporator to the condenser without any significant heat transfer to the pipe wall. Heat pipes can be designed to operate in evacuated tube collector, flat plate collector or directly at different working conditions and temperatures. Heat pipes needs to be installed at a minimum tilt angle of 25° to provide the backflow of the working fluid inside the heat pipe from condenser to evaporator.
Solar water heating (SWH) collectors are heat traps that absorb solar energy and transfer the heat into another medium. Changing the shape, design and materials, they have three major parts in common integrated to each other. The first and the most important part is collector which is exposed to solar radiation at an optimum inclination angle allowing to take maximum radiation throughout the solar season. The second part is a transfer medium that transfers the heat collected by the collector to the third part, storage tank. This medium should be fluid and generally made of water-glycol mixture. Storage tank, the third main part, is a simple heat exchanger (liquid-to-liquid) like collector (gas-to-liquid), which transfers the heat from the transfer fluid to the water to be heated and used. The transfer fluids have to be circulated in order to carry the heat continuously coming into the collector as solar radiation. This circulation is accomplished by mainly two ways:
There are many types of solar water heating (SWH) systems. Stationary type solar water heaters include flat plate collectors (FPC), evacuated tube collectors (ETC) and compound parabolic collectors (CPC). FPC and ETC are widely used for heating domestic use water. These collectors convert solar radiation directly and indirectly into thermal energy. ETCs have a higher efficiency than FPCs but they cost much more than FPCs.
Flat plate collectors are the most widely used solar systems today. They are made of three main parts. An insulated collector case holds the tubes, metal plate and glass cover. A sheet metal plate of aluminium, copper or steel can be painted or coated black. Metal tubes (usually aluminium or copper) that bonded onto the metal plate so as to provide good heat conduction, and are all connected to a common tube at both ends called header tubes. Bottom side of the collector case is well insulated to minimize thermal loses and the top side which is exposed to the sunlight is covered with a glass tightly to ensure a high level of greenhouse heating inside the collector. The pipes and copper are enclosed in an insulated metal frame, and topped with a sheet of glass (glazing) to protect the absorber plate and create an insulating air space.Figure 4. shows a cross section of a flat plate collector and solar water heaters with natural circulation and heat pipe.
(a) Cross section of the flat plate solar collector [
Sunlight falling onto the collector surface passes through the glass cover and hits to the black plate and tubes inside the collector casing. The heat absorbed by the tubes and the plate is transferred to the fluid circulating inside the tubes. The fluid which can either be a working fluid which circulates in a closed loop between the collector and storage tank where it transfers its energy to the water that will be used, or running water can be directly routed through the collector tubes. The circulation of the water inside the collectors can be driven by the difference between the specific gravity of heated water inside the collector and cooled water inside the storage tank, which is called natural circulation. This type of collector has some installation requirements such as installing the storage tank higher than the collector to provide cold water to flow downward replacing the hot water. Forced circulation on the other hand makes it possible to install the storage tank to almost any place lower than the collector which allows more aesthetic and convenient designs on the roof.
Evacuated-tube collector is a later generation of flat plate collectors which was first seen in 1970s. Main difference of evacuated tube from the flat plate collector is that it employs a vacuumed glass tube with an absorber inner surface. Vacuum layer serves as insulation much more superior than the air trapped between the glass cover and absorber plate in the flat plate collectors. Evacuated tube collectors are mainly two types as direct flow and heat piped system. Using a reflector improves the heat absorption performance of the collector.
Heat pipe evacuated-tube collectors use a copper heat pipe attached to an absorber plate and a vacuum tube. Tubes can be changed one by one without dismantling and emptying the whole system which makes it easy to perform installation, maintenance and repair tasks more easily. Some heat pipe collectors have overheat protection system that blocks the way fluid flows from the condenser to the evaporator region by a temperature triggered spring.
Concentrating solar systems are mainly used for power generation. They concentrate the solar energy to a point or a line at which heat energy is collected at medium or high temperatures depending on the type of the system and used for power generation in a conventional heat-driven power plant. Installed global capacity of concentrating solar thermal power plants according to years are 0.4 GW in 2004, 2.5 GW in 2012 and 3.4 GW in 2013, clearly showing an increasing trend [20]. Most popular types of concentrating solar power technologies include Linear Fresnel, dish, parabolic trough and solar towers Figure5.
Concentrating solar power technologies (a) Linear fresnel collector, (b) dish collector, (c) parabolic trough collector and (d) solar towers[
Among these concentrating solar technologies, parabolic trough is the most widely used technique in the world today. PTC and TSP technologies are able to store heat more than 10 hours through direct or indirect energy storage systems. There are 76 concentrating solar power projects in the world with 2.88 GWe of total capacity. Although PTC plants are very dominant among the currently operational solar power plants (95.7%), under construction projects will increase the ratio of LFC from 2.07% to 5.74%, TSP from 2.24% to 20.82% and SDC from 0% to 0.052%, decreasing the ration of PTC from 95.7% to 71.43% [22].
Photovoltaic (PV), as its name implies, is an extraordinary phenomenon that converts light to instantly ready direct current. Semiconductor materials inherently have this physical property and are easily used in production of PV cells. PV cells have two or more layers of semiconducting material, commonly silicon. When the photons in sunlight hits onto this semiconductor layers electrical charge is generated and this charge can be harvested by using metal contacts resulting in DC current. The smallest unit of this arrangement is called solar cell. Solar cells have a very small output capacity but they can easily be connected to each other to form a bunched structure called PV panel. PV panels can also be connected to each other in any size and number to produce a desired power output. PV panels have no emission, no noise and no moving parts. Also, their installation and maintenance tasks are very easy [23]. The main drawback of PV panels is their cost which is decreasing rapidly. Affordable prices boosted the use of PV panels in recent years. Global installed capacity of PV plants was 2.6 GW in 2004, increased to 100 GW in 2012 and become 139 GW by the year 2013 [20].
Desalination of sea water or other salty ground waters is a practical and proven method of producing fresh water where it is needed. The main issue for this desalination process is a low cost, environment friendly, readily available energy to drive the process. Solar energy is one of the best sources of this type and it is abundant throughout the year especially in solar belt region at which most of the water scarcity is suffered by about 5 billion people. Solar water desalination is a well-known and proven technique which has been used for a long time at remote areas and places suffering from shortage of potable quality water. There are many variations of solar driven desalination systems. Figure 6 shows a pull classification and integrated big picture view of desalination processes and the place of renewable energy among the other methods. These systems can be classified mainly into two groups as direct and indirect desalination systems which will be described below.
Most of the large solar desalination plants are driven by indirect solar energy. Indirect solar desalination systems can be classified into thermal, mechanical or electric driven technologies. Solar energy is collected through concentrating (PTC, LFC, TSC, SDC) or non-concentrating (FPCs, HPC, SP) collectors to run thermal desalination processes such as MSF, MED, thermal vapour compression (TVC) and membrane desalination (MD). Another indirect use of solar energy in desalination system is producing electricity from solar irradiation via PV panels and use to run ED which is the only desalination technology using electricity directly to produce fresh water. RO and freezing desalination techniques require mechanical energy which can be obtained from solar energy through heat engines (Rankine, sterling and brayton) or PV panels. Figure7 shows the shares of desalination technologies in indirect solar desalination plants installed worldwide.
Desalination techniques used for fresh water production [
Shares of desalination technologies in indirect solar desalination plants installed worldwide [
Pressurized feed water required for RO process can be provided by using either sterling or Rankine engine using solar heat, or using electric motor powered by PV panels. Since the usability of solar energy depends on season or weather conditions, sustainable and continuous production of fresh water requires taking some additional measures like energy storage such as thermal energy storage and battery, or hybridization with other energy sources like wind, geothermal and diesel, or with another desalination method combined with RO. Although the pre-treatment of water before the RO membrane reduces the energy efficiency, it is still more efficient than phase change thermal processes. Separated brine water with high pressure can be rejected after passing through a pressure exchanger to recover some of the wasted energy. Figure8illustrates a basic RO system powered by a solar-heated Rankine turbine. The waste heat of the cycle may be reused to preheat the feed water.
Basic diagram of a reverse osmosis system powered by a solar-heated Rankine cycle [
As shown in Figure 9, cold salt water travels through the stages from cold side to hot side absorbing heat inside the vessel to cause condensation of steam and formation of distilled water. The vessels here serve as an evaporator as the brine evaporates inside. Although higher number of stages increases efficiency, it also increases the installation costs. Therefore, there are about 19–28 stages in modern large MSF plants. Preheated salt water exits the hottest (or the first) stage and enters to the collector to absorb additional heat and enters to the first stage vessel. The first stage vessel is adjusted to a certain pressure that the entering hot brine is over the boiling temperature for that pressure. Therefore, a portion of the incoming brine water suddenly evaporates which is called the “flash”. Steam produced by this flash hits to the condenser above and becomes liquid condensate which drops on a fresh water collector and taken out as fresh water through a controlled valve. Demister is used to trap the water particles that may burst up during the flash and mix with the fresh water [27].
MSF plants can be integrated to any heat sources including solar concentrating (PTC, LFC, TSC, SDC) collectors, solar pond and flat plate, evacuated and heat piped collectors and any type of waste heat at moderate temperatures (from a steam or gas turbine power plant etc.).
Schematic view of (a) one stage flash distillation, (b) two stage flash distillation [
MED system is also able to operate by mechanical vapour compression (MED-MVC) when there is no usable heat. A mechanical compressor sucks the vapour from the last cell producing vacuum which promotes evaporation and compresses the vapour before sending to the heat exchanger of first cell with elevated temperature caused by the compression which also increases the evaporation rate in the first cell. MED-MVC system operates similar to MED-TVC cycle except for the mechanical compressor.
Typical arrangement of a multiple effect solar distillation with thermo-compression (MED-TVC) [
Direct solar desalination methods make use of the heat energy contained in the solar irradiation directly to produce fresh water without association with any other mechanical or electrical devices. Direct systems are low cost and suitable for small applications. Since their operation temperature and steam pressure is low, they have smaller production rates than indirect desalination systems. There are mainly two types of direct desalination technique such as humidification-dehumidification method and solar stills. Solar stills have also two variants as active and passive distillation methods.
A gigantic scale HD-DHD method is used in the nature for millions of years to produce fresh water from the seas and oceans using the sun as the heat source [29]. As shown in Figure 1, water evaporates and humidifies the above air. Air flows in the atmosphere carries the vapour to where it will condense and dehumidify to form fresh precipitation called rain, snow or hail. HD-DHD distillation method is the small scale replication of this process.
The productivity of HD-DHD system is about five times the productivity of an equivalent basin type solar still at the same climatic conditions. HD-DHD process is also named as the multiple-effect humidification-dehumidification process; multiple-effect humidification (MEH) or solar multistage condensation evaporation cycle (SMCEC).
In HD-DHD system atmospheric air is heated through a solar air heater. Because the water vapour holding capacity of air increases by the temperature (about 100 gr vapour/ kg dry air at 60°C and 500 gr vapour/kg dry air at 80°C) [30]. Warm dry air enters in to the humidification chamber and absorbs vapour from sprayed salt water. It passes through a pipe into dehumidification in which cold salt water passes through another pipeline which acts as a condenser for incoming warm humid air. Thus the salt water is preheated by the heat, recovered from condensing vapour, to utilize evaporation in the humidification chamber and the warm air is dehumidified leaving fresh water at the bottom of dehumidification chamber. Figure 11 shows the schematic illustration of HD-DHD system. Building and operating an HD-DHD system is simple safe and low-cost making it a very suitable desalination process among the small capacity plants [31].
Schematic diagram of humidification-dehumidification system [
Solar stills can be used to produce fresh water from salt water in a very cheap, simple and easy way [32]. They are preferred for small-scale fresh water needs of people in remote places instead of transporting fresh water. A very fortunate aspect of the solar water distillation technique is that when fresh water demand is at its peak, solar insolation is also high (especially hot seasons) [6].
Solar irradiation passes through a cover and falls onto the black bottom surface of the still causing the surface and contained salt or brackish water to warm up. Heated water evaporates and rises up until it touches to the inner side of the cover where it condenses and forms fresh water drops. Since the cover of the still is designed with a tilt angle, these drops are moved by gravitational forces towards the distilled water collecting channels. Figure 12 shows the schematic view of a double-slope symmetrical basin still (also known as, roof type or greenhouse type). The weak point of solar stills is the significant amount of heat loses because its large surfaces are in contact with the ground and air.
Distribution of the solar energy falling on a double slope symmetrical basin still [
Ground side can be insulated to some extent. However, the upper side which has to be exposed to solar irradiation cannot be insulated and there is serious amount of heat lose through radiation, convection and condensation of vapour on the cover surface. The performance of a solar still is closely related to the thermo physical properties of the material to be used in the still, tilt angle of cover, spacing between cover and water surface, insulation, vapour tightness and absorbance-transmittance properties of still, etc. as well as operating parameters such as water depth in the basin, initial water temperature, water salinity, etc.
Figure 12 shows the distribution of the solar energy falling on a basin still system. Ta, Tb, Tg and Tw in the figure are ambient temperature, basin temperature, glass temperature and water temperature, and
hwg, hga and hwb are the heat transfer coefficients from the water surface to glass, from the glass to the environment and from the water to basin liner respectively, given by Tiwari [35]. hew is the coefficient of heat loss by evaporation from water surface, Pg is the glass saturated partial pressure, and Pw is the water saturated partial pressure [35, 36].
Following Kumar et al. [37], the energy balance equations for different components of an active solar still are given as follows:
Sum of the radiation absorbed by the glass surface and the heat transferred from the water to glass surface is equal to the heat transferred from glass surface to the ambient.
Sum of the usable energy coming from the collector, the radiation absorbed by the water mass and the heat transferred from the basin liner (glass cover) to the water equals to the sum of heat stored in the water and the heat transferred from the water surface to the glass surface.
Solar radiation absorbed by the basin liner is equal to the sum of the heat transferred to the water by convection and the heat transferred from the surface to the ambient.
If the rate of useful energy coming from the collector (W) is zero (
Hourly output of still is [35, 38]
The efficiencies were calculated by the following equation [35, 39]:
Solar stills are mainly of two types according to their operation modes and modifications as active or passive solar stills. Active solar stills typically use a secondary external heat sources such as; collector/concentrator panel, solar pond, hybrid PV/T systems, waste thermal energy from any chemical/industrial plant, etc. If there is no supplementary external heat source, the system is called a passive solar still [40].
Passive distillation systems are divided into two groups such as high temperature (≥60°C) and normal temperature (≤60°C) distillation systems. High temperature passive distillation systems are horizontal basin still, inclined basin solar still, regenerative effect solar still, vertical solar still and spherical condensing solar still. Normal temperature passive distillation systems are inclined solar still, new designs of solar still and conventional solar still. Basin type is the most widely used solar stills today. Basin type solar stills have been modified into several types according to their cover designs such as; single slope, double slope, V type and hemispherical as shown in Figure 13. Average distillate production rate of a standard single-basin still is between 0.005 and 0.011 m3 m-2 day-1 depending on the insulation quality [32].
Different designs of basin type solar stills have been developed and tried to find an optimum solar still which; can be transported to the site and assembled easily, does not require rare materials that cannot be found easily, has an acceptable service life, can operate by itself without any need for external power support, has a rainfall collecting facility and does not pollute or contaminate the fresh water and of course with low cost.
Common design of solar stills: (a). single-slope basin still, (b). double-slope basin still, (c). V-type solar still, (d). Hemispherical type solar still [
Integrating a separate external condenser with the still as in Figure 14 decreases the convective heat loss through the still cover and provides an effective heat sink for the condensing vapour which increases the distillate yield by about 50–70%.Some of the evaporating water condenses on the cover surface and a fraction of the vapour passes to the condenser chamber by the effect of pressure difference causing the pressure in the still chamber to drop. Lowered pressure decreases the formation rate and number of vapour droplets on the inside surface of the still cover which allows more solar radiation to reach the water in the still basin and improves evaporation.
Using nano fluids along with external condenser is another contemporary method to further increase the productivity by about 115% [42]. External condenser accumulates the latent heat of condensing vapour which can be used to preheat salt water before entering the still or to prolong the distillation process during night hours. Using external condenser makes it possible to use a cover with very low inclination Figure 14a [43].
(a) Schematics of the solar still with minimum inclination, coupled to an outside condenser [
Conventional basin type solar stills have significant disadvantages; horizontal water surface inevitably causes cosine loses especially at higher latitudes and large thermal capacity of the water in still basin limits fresh water output. Many researchers and new designs have been done to minimize or overcome these drawbacks of solar stills [46].
Stills with inclined absorber surfaces are reported to have significantly higher productivity compared to basin-type stills. In an inclined still, water flows from the top to the bottom of the absorber surface. To maintain uniform thickness of water, a wick is used to draw water by capillary effect. The productivity of a solar still is affected by the temperature difference between the water and condensing surfaces. A higher temperature difference between these surfaces yields higher productivity. To maintain this temperature difference, various methods were proposed [47].
In inclined stills feed water coming from the tank comes to the collector in pipes, passes through the drilled holes and drops onto the black absorber plate to evaporate by taking heat from the plate which is heated by solar irradiation. Vapour goes up and touches to the glass cover which is cool enough to condense on. Fresh water distillate accumulates on the inner surface of the glass cover and flows downwards to the condensate outlet port by gravitational forces.
Water droplet falling onto the absorber plate does not distribute perfectly on the absorber plate surface. Using a wick on the absorber plate helps to distribute water more evenly over the absorber plate using capillary effect which improves evaporation rate. Another way of improving the performance is to cool glass cover to ease condensation. Shaded plate is a simple yet effective solution (Figure 15). One fourth of the glass surface is shaded from the top leaving a gap of several centimetres between the shading plate and the glass. This arrangement provides a chimney effect in this gap and improves convective heat transfer to the atmosphere which cools down this part of the glass and increases the condensate production rate [47].
A good way to solve the cosine loss problem of basin type solar still is to design an inclined structure with cascaded weirs (Figure 16) [48]. Salt water is fed from the top and condensate is collected from the bottom end. Feed water flows through the weirs and fills all the weirs evenly. There is a small distance between the cover and absorber plate which quickens the saturation and condensation processes making the cascade system more efficient more than other solar stills.
Weir-type cascade solar stills do not suffer from dry spot or channelization problems since the brine is forced to flow each step one by one without leaving any dry surface on the absorber plate. Water flow way is longer than a normal or wicked inclined type stills and accordingly the solar exposition time is longer which increases the efficiency. It has the advantages of both basin type and inclined type solar stills. Further development of these weir-type cascade stills include using wick on each cascaded steps and phase change material (typically paraffin wax) beneath the absorber surface to store energy when it is abundant and give it back to the salt water when it is needed in cloudy days or evening times [48].
Inclined solar water distillation system and schematic diagram of the system [
Schematic view of a weir type cascade solar still [
Another well-designed still is a combination of a glass cylinder and a tray or trough inside the cylinder (Figure 17a). Salt water is fed into the tray and the water travels through the tray. Incoming solar energy heats the tray and water to cause evaporation of salt water and consequently condensation of the vapour on the cylinder surface. Water droplets slip down and accumulate at the bottom of glass cylinder and collected through the fresh water outlet. Cylindrical tube type stills are compact, robust and have high yield per unit are compared to the conventional basin still design [50]. There is a similar design in which wick is used in the tray to absorb salt water and diffuse throughout the tray with capillary effect. Wick lies along an incline, with the upper edge dipped in a saline water reservoir and there are two outlets, one for the excess water and the other is for condensate. Capillary suction of the cloth fibers used as wick produces a thin water film which can easily evaporate by the incoming solar radiation. The condensing surface area of the cylindrical glass over the evaporation tray is much more than that of a flat surface and this results in a relatively colder glass cover faster condensation rate [46].
A similar approach uses a sphere instead of cylinder as the still housing. A black painted of covered metallic plate is located at the centre plane of the spherical glass (Figure 17b). Spherical solar stills works like cylindrical ones and they are about 30% more efficient than an equivalent conventional solar still. Spherical stills have even more condensation area per evaporation surface compared to cylindrical solar stills but it is not scalable as easy as cylindrical ones [46].
Schematic representation of (a) tubular solar still (front view) [
Many investigations have been conducted in attempt to improve the efficiency and productivity of solar stills. Some of these techniques are decreasing the depth of water in the basin, mixing black dye with the salt water, using better insulation to minimize the heat losses, improving the vapour tightness, proper orientation of the still as to receive more solar irradiation, etc.
Apart from the above-mentioned passive methods, there are a number of active methods of improving thermal efficiency such as integrating a still with a solar heater of concentrator. Active solar stills receive additional thermal energy from an outer source to the water in the basin which improves the rate of evaporation. A detailed classification of active and passive solar stills is given in Figure 6. Active solar stills are classified according to the integration type and operation principles of the solar stills. The main classification categories are: nocturnal distillation, pre-heated water distillation and high-temperature distillation solar stills.
Latent heat of condensation is one of the most significant heat losses of solar distillation systems. Finding a way for the re-utilization of this heat would greatly increase the thermal efficiency of the solar distillation system, which is defined as the daily production per square meter. One of those ideas is re-using the latent heat of condensation at the cover of a basin to heat the water in another basin [46]. Such a design is called multi-basin solar stills (Figure18). In multi-basin design, two or more basins are constructed like the floors in an apartment building. The bottom-most basin is covered by an absorber plate while the upper basins are transparent to allow solar radiation to reach the bottom plate. Condensing vapour at each basin cover heats up the cover by the latent heat of condensation. Heated cover of a basin forms basin of the upper still section and heats the water on it by that latent heat by re-utilizing the waste heat. Each section has its own condensate collection and salt water feeding channels.
Schematic view of a double basin solar still. (b) Double basin still coupled to a collector in the natural circulation mode. (c) Double basin coupled to a collector in the forced circulation mode [
As shown in Figures 19 and 20, flat plate collectors and evacuated collectors can be used in active solar distillation systems. Solar collectors have high efficiency and improve the amount of distillation. However, the collector should be used in closed cycle to avoid precipitation of salt and other contaminants in the tubes and demolish the performance of the collector. Instead, a heat exchanger should be used (Figure 20) to transfer the heat to the basin water of the still [34].
Vacuum tube collector assisted solar distillation system [
Flat plate solar collector assisted active distillation system and its schematic view
Solar stills can be successfully integrated with parabolic solar concentrators (Figure 21). Solar tracking parabolic concentrators concentrate the solar irradiation falling on a large area onto a small receiver area at high temperatures. High temperature and low heat loss area of the still basin which is located on the focal point of parabolic concentrator greatly improves the efficiency of the still. Salt water can be supplied to the still by natural or forced circulation [52].
Schematic of a concentrating collector still [
Since the most critical stages of distillation process are evaporation and condensation, any measures that helps these two stages increases the efficiency significantly. A clever idea for promoting the evaporation at a certain temperature is forced air bubbling which causes an instantaneous atomization of water towards the air and a rapid evaporation. If it is possible to pre-heat the air that will be used for bubbling evaporation would be much better since the air that will carry the vapour also has the extra heat that evaporation process requires instantly during the bubbling effect (Figure 22). Another effective way of improving the still efficiency is cooling the cover surface [46, 52].
Air-bubbled solar still [
In a recent design, evacuated solar collector is hybridized with wicks/solar still to improve the productivity of still (Figure 23). Using single layer or double layer wick on absorber plate and integrating a feed water tank to feed hot salt water which is heated by solar collector during the daytime made up of a great combination of wick, inclined solar heating and energy storage which boosted the thermal performance and operation time of the still [53].
Schematic diagram of hybrid desalination system using wicks/solar still and evacuated solar water heater [
Making a general consideration of the solar stills, some common results can be concluded:
Fresh water yield of a solar still depends on several parameters like solar insolation, ambient air temperature, wind speed, atmospheric humidity, sky conditions etc.
The inclination angle of cover should be equal to the latitude of the installation site to minimize the cosine loses.
Increasing water depth in the still basin decreases the distillate production rate.
Each type of solar still has its own advantages and disadvantages. None of them is perfect.
Increasing salinity of the salt water decreases the distillate production rate especially at low concentration range.
Due to inclination angle single slope passive solar stills are better than double slope passive solar stills.
FPC with forced circulation mode increase the performance solar still more than thermo syphon mode.
Wind can slightly increase the total production.
Although from morning to noon the highest distillate output are obtained at the highest water temperature times, more outputs can be observed at less water temperatures which can be attributed to the cooling glass cover before the system itself.
Double slope passive solar still has a higher thermal efficiency than double slope active solar still.
In active double effect solar stills lower basin gives the maximum yield because of the high noon temperature.
The amount of fresh water produce in the still is closely related with thermal conductivity of condensing cover material.
Drinkable fresh water, being a fundamental need of human being, has become a serious concern for people especially living in crowded cities and countries with limited amount of water resources. Supplying fresh water is an energy intensive task especially when there is need for heating cold water to evaporate for distillation. Most of the big desalination plants around the world use fossil-based fuels as energy source to heat and vaporize the sea water or brackish water in order to produce fresh water. However, environmental concerns along with decreasing oil reserves and increasing fuel costs call for reconsideration on the fuel types used in many areas as well as in desalination or distillation processes. There are a number of well-known alternative and renewable energy sources in the world like wind, geothermal, solar, biomass etc. but achievability, availability when needed and energy storage are also very critical issues to operate the distillation plant effectively.
A very fortunate aspect of the issue is the coincidence of fresh water need and abundant solar energy. Most of the places with severe water scarcity are about the equator region where people needs more water due to highest degrees of air temperature in the world. Therefore, especially for these countries located in solar belt region, solar energy is a readily available, cost-free and abundant energy source which does not require transportation or very sophisticated technology to benefit from. Since most of the desalination processes run on heat, solar energy can be used directly as heat source which decreases the installation and operation costs significantly. Apart from simple solar powered stills, of course there are more complicated, yet much more efficient solar powered stills. Complex desalination systems which are all designed to improve the thermal efficiency and freshwater yield/productivity use many approaches such as: multiple stage operation, pre-heating the feed water with the condensation energy, using additional heat sources (waste water from another process), concentrating solar energy to improve the operation temperature of the process etc.
Solar desalination systems can be a good solution to the water scarcity of especially the Sunbelt region. However, dominant use of clean and renewable energy sources for desalination process and replacement of the fossil fuel-based operations require more R&D studies to find more efficient and/or less costly power plants with continuous operation by the means of energy storage solutions.
Ac\n\t\t\t | \n\t\t\tArea of collector (m2) | \n\t\t
Α | \n\t\t\tAbsorptivity | \n\t\t
CPC | \n\t\t\tCompound parabolic collectors | \n\t\t
cw\n\t\t\t | \n\t\t\tSpecific heat of water in solar still (J/kg K) | \n\t\t
ED | \n\t\t\tElectro dialysis | \n\t\t
ETC | \n\t\t\tEvacuated tube collector | \n\t\t
FPC | \n\t\t\tFlat plate collector | \n\t\t
FR\n\t\t\t | \n\t\t\tHeat removal factor | \n\t\t
hb\n\t\t\t | \n\t\t\tOverall heat transfer coefficient from basin liner to ambient air through bottom and side insulation (W/m2 °C) | \n\t\t
HD-DHD | \n\t\t\tHumidification-dehumidification | \n\t\t
hew\n\t\t\t | \n\t\t\tHeat loss coefficient by evaporation from water surface (W/m2K) | \n\t\t
hwg\n\t\t\t | \n\t\t\tHeat transfer coefficient from the water surface to the glass (W/m2K) | \n\t\t
hga\n\t\t\t | \n\t\t\tHeat transfer coefficient from the glass to the ambient (W/m2K) | \n\t\t
hwb\n\t\t\t | \n\t\t\tHeat transfer coefficient from the water to the basin liner (W/m2K) | \n\t\t
HP | \n\t\t\tHeat pipe | \n\t\t
Ic\n\t\t\t | \n\t\t\tSolar intensity on the glass cover of the solar collector panel (W/m2) | \n\t\t
| \n\tEffective solar radiation intensity (W/m2) | \n
L | \n\tLatent heat of vaporization (J/kg) | \n
LCZ | \n\tLower Convective Zone | \n
LFC | \n\tLinear Fresnel collector technology | \n
MED | \n\tMultiple effect distillation | \n
MED-MVC | \n\tMechanic vapour compression MED | \n
MED-TVC | \n\tThermal vapour compression MED | \n
MEH | \n\tMultiple-effect humidification | \n
Mw\n\t | \n\tMass of water in basin (kg) | \n
| \nHourly output of still (kg/m2h) | \n
\n\t\t | \n\tSalt mass fraction | \n
MSF | \n\tMulti-stage flash | \n
NCZ | \n\tNon convective zone | \n
Pg\n\t | \n\tGlass saturated partial pressure (N/m2) | \n
Pw\n\t | \n\tWater saturated partial pressure (N/m2) | \n
PTC | \n\tParabolic trough collector | \n
| \nEvaporative heat transfer (W) | \n
| \nRate of useful energy from collector (W) | \n
RO | \n\tReverse osmosis | \n
SDC | \n\tSolar dish collector technology | \n
SGSP | \n\tSalt gradient solar pond | \n
SMCEC | \n\tSolar multi-stage condensation evaporation cycle | \n
SWH | \n\tSolar water heating | \n
Τ | \n\tTransmittance | \n
Ta\n\t | \n\tAmbient air temperature (K) | \n
Tb\n\t | \n\tBasin temperature (K) | \n
Tg\n\t | \n\tStill glass cover temperature (K) | \n
Tw\n\t | \n\tStill water temperature (K) | \n
TSP | \n\tTower solar power technology | \n
UCZ | \n\tUpper convective zone | \n
UL\n\t | \n\tOverall heat transfer coefficient (W/m2 °C) | \n
V | \n\tWind speed (m/s) | \n
VC | \n\tVapour compression | \n
| \nSolar flux absorbed by the basin liner | \n
| \nSolar flux absorbed by glass cover | \n
| \nSolar flux absorbed by water mass | \n
\n\t\t | \n\t\n |
c | \n\tCollector | \n
Angiosperms have two reproduction routes: gametophytic (sexual) and apomictic (asexual). The first form of reproduction leads to seeds with an embryo from the union of the egg cell nucleus with one of the generative nuclei from the male gamete producing a plant with genetic characteristics different from the female parent. This process promotes genetic diversity through hybridization and the adaptation of plants that allows the conservation of species [1]. We will start this chapter by describing the apomictic process and the evolutionary mechanism of alternate pathways that have allowed cloning plants using seeds [2], including most citrus species.
Various mechanisms intervene to generate asexual embryos, eluding the fundamental aspects of sexual reproduction: meiosis and fertilization [3]. According to the mechanism of embryogenesis, apomixis comprises gametophytic apomixis (apospory and diplospory) and adventitious embryony. In these, apomictic embryos have maternal inheritance, but each mechanism is associated with a different probability of producing sexual offspring, varied selection pressure to maintain male fertility, and expected levels of genetic diversity within populations [4]. In apospory, the initial cells form unreduced embryo sacs from direct mitosis and can coincide with sexual embryogenesis: if endosperm forms, the process is pseudogamic, or autonomous if it does not [5]. This second route, which occurs in less than 1% of angiosperms, comprises the development of embryos from somatic cells.
Similarly, in diplospory, the megaspore does not undergo meiosis and through mitosis forms an unreduced embryo sac with cells arranged as in the Polygonum type (sexual reproduction); but the sexual process is wholly compromised [5]. Whereas in adventitial apomixis, the development of the sexual embryo sac seems to develop normally, and after fertilization and development of the sexual embryo, somatic embryos develop from nucellar or integumental cells [6, 7]. In citrus, adventitious embryonic development does not occur without zygote formation (apomixis is facultative), depends on endosperm formation, and is simultaneous with the development of sexual embryos [6, 8, 9]. Therefore, when the embryo sac expands, the embryogenic cells of the nucellus enter the endosperm, competing for space and nutrients with the zygotic embryos that may or may not complete their development [10].
Adventitial embryony or sporophytic apomixis frequently occurs in Rutaceae, Celastraceae, and Orchidaceae; furthermore, it is common in tropical and subtropical trees and shrubs [4]. Polyembryony in citrus is a type of sporophytic apomixis that occurs in most of its species and hybrids (Table 1). For example, in 12 genotypes (Sikkim, Thorny, Kinnow and Cleopatra mandarin, Calamondin, Nova×Orlando hybrid, Minneola tangelo, Thornton, Parramatta, Parson Brown, Smooth Flat Seville, and rough lemon rootstock) rates of polyembryonic seeds ranged from 69.8% to 91.4%, with up to 14 embryos per seed [8]. The following genotypes do not show polyembryony, thus classified as non-apomictic:
Citrus genotypes | Polyembryony (%) | Range of embryos/seed | Author |
---|---|---|---|
Amblicarpa mandarin | 82.1 | 2-15 | [11] |
Amblicarpa mandarin | 91.5 | 4.9 | [12] |
C-35 citrange | 86.5 | 3.95 | [12] |
Cipó sweet orange | 98 | 28.8 | [13] |
Cleopatra mandarin | 84.7 | 1-26 | [11] |
Cleopatra mandarin | 97.1 | 8.01 | [14] |
Cravo Santa Cruz Rangpur lime | 58.5 | 1.97 ± 1.08 | [15] |
Flying dragon trifoliate orange | 40 | 1.70 ± 1.11 | [15] |
Indio citradarin | 100 | 13.52 ± 4.40 | [15] |
Minneola tangelo | 77.5 | 3.45 | [12] |
Morton citrange | 86.8 | 5.87 | [14] |
Rangpur lime | 43.3 | 1.87 | [14] |
Riverside citradarin | 100 | 12.97 ± 3.86 | [15] |
Rough lemon | 96.2 | 4.89 | [14] |
Rusk citrange | 92.3 | 5.05 | [14] |
San Diego citradarin | 97.5 | 6.29 ± 3.19 | [15] |
Smooth Flat Seville sour orange | 29 | 22.7 | [13] |
Sunki mandarin | 66.2 | 1.8 | [14] |
Sunki Tropical mandarin | 100 | 8.97 ± 2.76 | [15] |
Swingle citrumelo | 64 | 2.48 ± 1.47 | [15] |
Swingle citrumelo | 65 | 2.96 | [14] |
Troyer citrange | 95.1 | 6.95 | [14] |
Valencia orange | 95.5 | 4.5 | [12] |
Volkamerian lemon | 37.8 | 2.50 | [11] |
Volkamerian lemon | 85.5 | 3.15 | [12] |
Volkamerian lemon | 52.2 | 2.57 | [14] |
Yuma citrange | 21 | 1.36 | [14] |
Yuma citrange | 31 | 4 | [13] |
Percentage of polyembryony and embryos per seed in apomictic genotypes of citrus.
The study of polyembryony is receiving increased attention from both industrial and scientific sectors as it provides a form of cloning through seed that avoids the typical complications of sexual reproduction (for example, incompatibility barriers) and vegetative propagation (replication of viruses and other diseases) [20]. Another possible benefit of asexual reproduction by seed implies fixing the hybrid vigor and allowing the propagation of hybrids through many generations of seeds [21]. However, even in 2021, in [22] indicated that fixed hybrid vigor has not been possible because hybrid seeds cannot produce offspring with the same qualities.
Over the years, attempts to link the morphological characteristics of fruits, seeds, and embryos with polyembryony or with the characteristics of nucellar or zygotic embryos to predict the sexual or asexual origin of seedlings have taken place. Some researchers have studied the relationship between fruit weight and polyembryony in Swingle citrumelo, Volkamerian lemon, Cleopatra mandarin, and Amblicarpa [11, 23]. Other studies have tried to select characteristics of polyembryonic seeds as a possible method to anticipate the origin, zygotic or nucellar, of seedlings. For example, the size and shape classification of seeds has been associated with the production of zygotic seedlings on rootstocks [24, 25]. Also, logistic regression models that predict sexual seedlings have been developed [13].
Another variable that has been considered in the possible prediction of predominant sexual or asexual reproduction is the relationship between the percentage of polyembryony in citrus genotypes and the production of nucellar seedlings. Different studies have shown that species with a higher percentage of polyembryony are less likely to develop zygotic seedlings [21, 26, 27] because only one zygotic embryo possesses competitive disadvantage against all nucellar embryos: zygotic embryos tend to be small and do not survive in field conditions. In contrast, more numerous apomictic embryos tend to be large and produce more vigorous seedlings. One case is
Other features of the embryos, such as size and location, have been studied to define the position and origin of nucellar and zygotic embryos. Zygotes often appear as more diminutive in seed size, with slower growth than adventitious embryos and growth prevailing at the micropylar end [31, 32]. However, during nucellar embryogenesis associated with the fertilized embryo sacs, there seems to be an inhibitory effect in the chalaza region [10, 33]. Consequently, both embryos preferentially grow towards the micropyle. These arguments are helpful to generate reproduction models in polyembryonic citrus; however, it should be noted that these studies focused on the initial stages of embryo and seed formation. Therefore, it is essential to develop innovative methods of identifying nucellar and zygotic embryos in mature seeds and differentiating the seedlings that originate in the early stages of development. We will cite the work of Andrade-Rodríguez et al. [28], who, using RAPD (Random Amplification of Polymorphic DNA) markers, in vitro culture, and embryo morphology, concluded that not all small embryos located in the micropyle produce zygotic seedlings in Volkamerian lemon seeds. This contribution generated various questions about the reproduction models proposed for citrus and motivated us to pursue our current research focus.
Our laboratory has studied polyembryony in citrus from 2000 to date (as well as in other fruit trees not mentioned in this chapter). We have used molecular markers, in vitro culture of embryos separated by size, and grafting of the plants obtained in the greenhouse. These techniques have produced plants from embryos one, two, three, four, five, six, and seven (Example: E1, E2, E3, E4, E5, E6 and E7 in Figure 1) and propose new approaches to study the relationship between size and sexual, asexual, or different origin of the plants obtained from each of the embryos. Among the works published in citrus are references [7, 11, 12, 28, 34].
Embryos classified by size in a seed of Amblicarpa mandarin (
Successfully harnessing apomixis for citrus propagation requires understanding its facultative nature; the formation of nucellar and zygotic embryos varies among environments and times of the year. Additionally, each species genetic makeup acts as an activation “switch” that relies on environmental changes. All these variables lead to variations in the degree of polyembryony, number of embryos per seed, and even the type of reproduction that will prevail, asexual or sexual [3, 30, 35]. Understanding the apomictic phenomenon in citrus is central to various studies to benefit from its dual characteristics: clonal propagation from seed and hybrids production. We seek to generate models that relate the characteristics of polyembryony, size, and location of the embryos in the seed, with their sexual or asexual origin. However, the selection of the hybrids that result from the cross with polyembryonic parents is complex if they do not express a reproducible dominant trait under several environmental conditions. In addition, the percentage of zygotic progenies in various citrus hybrids has been found to vary based on the seed parent used [36], the pollen origin [37], and environmental factors [38]. For this reason, researchers used various morphological, biochemical, and molecular markers to identify seedlings in the early stages of development.
Plant morphology is the first visible marker for hybrid selection in plant breeding. The first morphological trait used to differentiate nucellar plants from zygotic ones relied on linking vigor with asexual origin. For example, in 1949 in Ref. [39] published that nucellar plants are those that develop juvenile characteristics, such as vigorous growth, presence of thorns, or slow fruiting. Another morphological marker, which is also a dominant phenotypic trait, is leaf morphology [26]. In Figure 2, Amblicarpa nucellar plant (Figure 2a) and the hybrid that exhibits more than one leaflet (Figure 2b) are compared; both plants have thorns, which according to Cameron and Johnston [39] are juvenile characteristics. It has been used in nurseries since the first decades of the 20th century to identify hybrids by crossing trifoliate genotypes. The method is still valid and is used to obtain trifoliate rootstocks such as citrandarins (Cleopatra mandarin× P. trifoliata). However, both the presence of juvenile traits and multifoliate leaves are markers that vary depending on environmental conditions and plant development, so they are unreliable [40].
Mandarin Amblicarpa seedling (Citrus amblycarpa (Hassk) Ochse), obtained from embryos in vitro cultured, grafted on Volkamerian lemon (50 days after grafting). 2a nucellar plant and 2b sexual plant, both plants show “vigor” in height, leaf development, and thorn size; however, the sexual plant develops leaflets.
Not all morphological markers can reliably distinguish between zygotic and nucellar seedlings [40]. The expression of “trifoliate leaf” is a dominant trait over the recessive unifoliate leaf trait makes it easy to identify the first-generation hybrid seedlings in crosses between unifoliate citrus and trifoliate orange male parents [41]. Thus, hybrid seedlings with multifoliate leaves would be expected to appear when crosses of trifoliate male parents (
Biochemical tests have also been used as genetic markers in discriminating zygotic seedlings. Such is the case of colorimetry [44], chromatography [45], polyphenol darkening [46], spectroscopy [47], and isozyme analysis techniques [48]; however, these techniques fail to identify all clones and ignore some hybrids. For example, although they are codominant markers with simple methods, isoenzymes express few polymorphic loci to differentiate F1 seedlings from the female parent. Additionally, their expression level is qualitatively and quantitatively affected by environmental factors, plant development stage, or physiological conditions [29, 30].
Molecular biology expanded the tools available for identifying seedling sexual or asexual origin through molecular markers based on PCR (polymerase chain reaction). Among the most used markers are RAPD (Random Amplification of Polymorphic DNA), ISSR (Inter Simple Sequence Repeat), SSR (Simple Sequence Repeat), and SNP (single-nucleotide polymorphism) [30, 34, 42, 43]. Various studies compare the efficiency of genetic markers in selecting hybrids, in Ref. [29] evaluated RAPD and EST-SSR (Expressed Sequence Tag-SSR), in [43] worked with morphological markers and SSR, and in [45] compared morphological markers and SNPs. RAPDs (dominant marker) and EST-SSRs (codominant marker) efficiently and accurately identified nucellar plants of mandarin (
Not only can genetic markers complement each other, but in vitro germination can also be used in embryo identification to increase the development of small embryos (which do not germinate under in vivo conditions). Similarly, faster acclimatization and growth of plants resulting from these embryos result from grafting on a rootstock. Three studies show the advantages of combining in vitro culture and identifying hybrids with SSR markers. It is worth mentioning that SSRs have been widely used to discriminate embryos according to their origin because they favor the selection of plants obtained by self-pollination and cross-pollination. Embryos from F1 seeds from a cross between ‘Shiranuhi’ mandarin and ‘Shiranuhi’ orange were cultivated
Dendrograms showing the Genetic Similarity Indices (GSI) between nucellar seedlings and the female parent, obtained from the largest embryo per seed in six polyembryonic citrus cultivars (A, Citrange C-35; B, Amblicarpa Mandarin; C, Volkamerian lemon; D, Parson Brown orange; E, Tangelo Minneola; F, Valencia orange). The GSI was calculated with 30 SSR markers.
Various works that use molecular markers to classify seedlings according to their sexual or asexual origin state that those with total similarity to the female parent are nucellar. In [29] consider seedlings of Swingle citrumelo (
One of the objectives of breeding programs is to select plants based on agronomic and economic traits, such as the expression of polyembryony. However, it is relevant to consider the advantage of using molecular markers. These have the possibility of generating QTL (Quantitative Trait Loci) by associating the polymorphism to a phenotypic trait. The QTL Apo1, Apo2, Apo3, Apo4, and Apo6 associated molecular markers (RAPD, SSR, and CAP -Cleaved Amplified Polymorphic Sequence) with apomixis in the progeny of
Despite the effectiveness of molecular markers to discriminate between hybrids and nucellar plants, ongoing efforts try to relate the expression of morphological features of the embryo and its location in the seed with sexual origin. The purpose is to separate hybrid plants from clonal plants from seed or in the early stages of development without a laboratory. Various studies have related polyembryonic traits and origin; however, we will only analyze the
Therefore, molecular markers and complementary techniques (in vitro culture and grafting) are adequate to identify sexual and asexual seedlings with greater certainty than the exclusive use of morphological markers. Nevertheless, the characteristics of these techniques need to be assessed based on the objective and possibilities of the investigation. For example, although RAPDs and ESS-SSRs show a similar capacity to differentiate zygotic and nucellar seedlings [29], RAPDs are simpler and cheaper than EST-SSRs. However, the latter shows greater reproducibility among laboratories and detects all alleles of a locus (codominance). In the case of SNPs, their limitation is the cost and availability of the necessary equipment in the laboratory. Instead, in vitro culture is an excellent technique to be applied in research where germination of embryos is required for subsequent identification, but it is expensive in commercial citrus propagation schemes.
Polyembryony in citrus is complex and affected by genetic, physiological, and environmental factors. Therefore, a better understanding of the development of the embryos in the seed requires further studies. We propose combining complementary techniques to molecular markers to identify the sexual or asexual origin, the individual follow-up of each embryo in the seed, and the subsequent evaluation of morphological and production characteristics of the plant. This process in citrus requires approximately 3 and 4 years to start fruiting. However, it is necessary to answer a few questions: If a seedling identified with molecular markers as “different or possibly zygotic” (with similarity indices less than 0.95) expresses these polymorphisms phenotypically? Do the embryos, based on their size and position in mature seeds, tend to be nucellar or possibly zygotic? Is it convenient to continue considering the percentage of polyembryony in citrus as a form of clonal propagation in nurseries? Are the plants obtained from the larger embryo asexual? These and so many more questions need further research.
The authors thank Postgraduate College for the facillities made available during these studies. We also thank Vivero Cazones for providing the plant material and plant care help. This work was supported by the Mexican Council of Science and Technology (CONACyT).
The authorship criteria are listed in our Authorship Policy: https://www.intechopen.com/page/authorship-policy.
This section of your manuscript may also include funding information.
The authors declare no conflict of interest.
IntechOpen books and journals are available online by accessing all published content on a chapter/article level.
",metaTitle:"Access policy",metaDescription:"IntechOpen books are available online by accessing all published content on a chapter level",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"All IntechOpen published chapters and articles are available OPEN ACCESS and can be read without the requirement for registration of any kind, immediately upon publication, without any barrier.
\\n\\nThe HTML version, as well as the PDF version of publications dated before 2012 that are accessible through a reader, are available to readers with no restriction.
\\n\\nThe full content of chapters and articles can be read, copied and printed from the link location of the chapter/article and these actions are not limited or restricted in any way.
\\n\\nRegistration is requested only to download the PDF of the chapter/article. There are no subscription fees and there is no charge to user groups.
\\n\\nIntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
\\n\\nAuthors may post published works to any repository or website with no delay, and Authors and Editors of IntechOpen books have direct access to the PDF of the full book.
\\n\\nAll published content can be crawled for indexing. Full text and metadata may be accessed with instructions publicly posted.
\\n\\nAll IntechOpen books and Journal articles are indexed in CLOCKSS and preservation of access to published content is clearly indicated.
\\n\\nPolicy last updated: 2022-04-14
\\n"}]'},components:[{type:"htmlEditorComponent",content:"All IntechOpen published chapters and articles are available OPEN ACCESS and can be read without the requirement for registration of any kind, immediately upon publication, without any barrier.
\n\nThe HTML version, as well as the PDF version of publications dated before 2012 that are accessible through a reader, are available to readers with no restriction.
\n\nThe full content of chapters and articles can be read, copied and printed from the link location of the chapter/article and these actions are not limited or restricted in any way.
\n\nRegistration is requested only to download the PDF of the chapter/article. There are no subscription fees and there is no charge to user groups.
\n\nIntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
\n\nAuthors may post published works to any repository or website with no delay, and Authors and Editors of IntechOpen books have direct access to the PDF of the full book.
\n\nAll published content can be crawled for indexing. Full text and metadata may be accessed with instructions publicly posted.
\n\nAll IntechOpen books and Journal articles are indexed in CLOCKSS and preservation of access to published content is clearly indicated.
\n\nPolicy last updated: 2022-04-14
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11658},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33642}],offset:12,limit:12,total:135272},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"1",sort:"dateEndThirdStepPublish",topicId:"5,6"},books:[{type:"book",id:"11616",title:"Foraging",subtitle:null,isOpenForSubmission:!0,hash:"955b60bb658c8d1a09dd4efc9bf6674b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11616.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11809",title:"Lagomorpha",subtitle:null,isOpenForSubmission:!0,hash:"1e8fd5779205c16e5797b05455dc5be0",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11809.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11794",title:"Coconut Cultivation",subtitle:null,isOpenForSubmission:!0,hash:"48e1cb42a4162f64cae3a2e777472f21",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11794.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12142",title:"Prunus",subtitle:null,isOpenForSubmission:!0,hash:"30b850eaa9714914bf001664c9b324be",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12142.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12146",title:"Cellulose",subtitle:null,isOpenForSubmission:!0,hash:"b1196cf20a9e42db795c2d647681aa9d",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12146.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12147",title:"Abiotic Stress in Plants",subtitle:null,isOpenForSubmission:!0,hash:"f3d8c31029650b7ce536da7ab9d7a5a0",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12147.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12148",title:"Cucurbitaceae",subtitle:null,isOpenForSubmission:!0,hash:"0029e5c84528142bf2eff0cbd5b14fa2",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12148.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12149",title:"Solanum tuberosum",subtitle:null,isOpenForSubmission:!0,hash:"39bdc8ce8b54bc666a3ab765a29c6edd",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12149.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12154",title:"Organic Fertilizers",subtitle:null,isOpenForSubmission:!0,hash:"8634d6ecdb6fc207336d8b95a169e400",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12154.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12156",title:"Legumes",subtitle:null,isOpenForSubmission:!0,hash:"a97becd6aa14a480ce28c05a3116f639",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12156.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12158",title:"Insecticides",subtitle:null,isOpenForSubmission:!0,hash:"247c6afbbb411e49d33864c1911b3242",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12158.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12179",title:"Melittology",subtitle:null,isOpenForSubmission:!0,hash:"f5873fd08f791e5405d4adb02508c0bf",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12179.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:30},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:3},{group:"topic",caption:"Business, Management and Economics",value:7,count:3},{group:"topic",caption:"Chemistry",value:8,count:12},{group:"topic",caption:"Computer and Information Science",value:9,count:7},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:11},{group:"topic",caption:"Engineering",value:11,count:19},{group:"topic",caption:"Environmental Sciences",value:12,count:4},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:7},{group:"topic",caption:"Mathematics",value:15,count:5},{group:"topic",caption:"Medicine",value:16,count:80},{group:"topic",caption:"Neuroscience",value:18,count:6},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:1},{group:"topic",caption:"Psychology",value:21,count:6},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:22}],offset:12,limit:12,total:33},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11263",title:"Supply Chain",subtitle:"Recent Advances and New Perspectives in the Industry 4.0 Era",isOpenForSubmission:!1,hash:"aab634c9c1f9a692c1e9881d18e9c9b7",slug:"supply-chain-recent-advances-and-new-perspectives-in-the-industry-4-0-era",bookSignature:"Tamás Bányai, Ágota Bányai and Ireneusz Kaczmar",coverURL:"https://cdn.intechopen.com/books/images_new/11263.jpg",editors:[{id:"201248",title:"Dr.",name:"Tamás",middleName:null,surname:"Bányai",slug:"tamas-banyai",fullName:"Tamás Bányai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4798},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7107,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1955,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1452,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2289,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11263",title:"Supply Chain",subtitle:"Recent Advances and New Perspectives in the Industry 4.0 Era",isOpenForSubmission:!1,hash:"aab634c9c1f9a692c1e9881d18e9c9b7",slug:"supply-chain-recent-advances-and-new-perspectives-in-the-industry-4-0-era",bookSignature:"Tamás Bányai, Ágota Bányai and Ireneusz Kaczmar",coverURL:"https://cdn.intechopen.com/books/images_new/11263.jpg",publishedDate:"July 27th 2022",numberOfDownloads:888,editors:[{id:"201248",title:"Dr.",name:"Tamás",middleName:null,surname:"Bányai",slug:"tamas-banyai",fullName:"Tamás Bányai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1566,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2054,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",publishedDate:"July 27th 2022",numberOfDownloads:780,editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318480,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271760,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"19",title:"Pharmacology, Toxicology and Pharmaceutical Science",slug:"pharmacology-toxicology-and-pharmaceutical-science",parent:{id:"3",title:"Health Sciences",slug:"health-sciences"},numberOfBooks:97,numberOfSeries:0,numberOfAuthorsAndEditors:2389,numberOfWosCitations:3048,numberOfCrossrefCitations:2061,numberOfDimensionsCitations:4951,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"19",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10882",title:"Smart Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"70c3ce4256324b3c58db970d446ddac4",slug:"smart-drug-delivery",bookSignature:"Usama Ahmad, Md. Faheem Haider and Juber Akhtar",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg",editedByType:"Edited by",editors:[{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10885",title:"Snake Venom and Ecology",subtitle:null,isOpenForSubmission:!1,hash:"cc4503ed9e56a7bcd9f2ca82b0c880a8",slug:"snake-venom-and-ecology",bookSignature:"Mohammad Manjur Shah, Umar Sharif, Tijjani Rufai Buhari and Tijjani Sabiu Imam",coverURL:"https://cdn.intechopen.com/books/images_new/10885.jpg",editedByType:"Edited by",editors:[{id:"94128",title:"Dr.",name:"Mohammad Manjur",middleName:null,surname:"Shah",slug:"mohammad-manjur-shah",fullName:"Mohammad Manjur Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editedByType:"Edited by",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9829",title:"Biosimilars",subtitle:null,isOpenForSubmission:!1,hash:"c72171c1d1cf6df5aad989cb07cc8e4e",slug:"biosimilars",bookSignature:"Valderilio Feijó Azevedo and Robert Moots",coverURL:"https://cdn.intechopen.com/books/images_new/9829.jpg",editedByType:"Edited by",editors:[{id:"69875",title:"Dr.",name:"Valderilio",middleName:"Feijó",surname:"Feijó Azevedo",slug:"valderilio-feijo-azevedo",fullName:"Valderilio Feijó Azevedo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10881",title:"Drug Repurposing",subtitle:"Molecular Aspects and Therapeutic Applications",isOpenForSubmission:!1,hash:"eca3f2d5ca97b457d38a2442b36d3ac7",slug:"drug-repurposing-molecular-aspects-and-therapeutic-applications",bookSignature:"Shailendra K. Saxena",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg",editedByType:"Edited by",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10234",title:"High-Throughput Screening for Drug Discovery",subtitle:null,isOpenForSubmission:!1,hash:"37e6f5b6dd0567efb63dca4b2c73495f",slug:"high-throughput-screening-for-drug-discovery",bookSignature:"Shailendra K. Saxena",coverURL:"https://cdn.intechopen.com/books/images_new/10234.jpg",editedByType:"Edited by",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11038",title:"Vaccine Development",subtitle:null,isOpenForSubmission:!1,hash:"2604d260662a3a3cc91971ea07beca61",slug:"vaccine-development",bookSignature:"Yulia Desheva",coverURL:"https://cdn.intechopen.com/books/images_new/11038.jpg",editedByType:"Edited by",editors:[{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10736",title:"Neurotoxicity",subtitle:"New Advances",isOpenForSubmission:!1,hash:"50dfa1a8daaa4a6171a0f6fde2e8d651",slug:"neurotoxicity-new-advances",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/10736.jpg",editedByType:"Edited by",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10502",title:"Aflatoxins",subtitle:"Occurrence, Detoxification, Determination and Health Risks",isOpenForSubmission:!1,hash:"34fe61c309f2405130ede7a267cf8bd5",slug:"aflatoxins-occurrence-detoxification-determination-and-health-risks",bookSignature:"Lukman Bola Abdulra’uf",coverURL:"https://cdn.intechopen.com/books/images_new/10502.jpg",editedByType:"Edited by",editors:[{id:"149347",title:"Dr.",name:"Lukman",middleName:"Bola",surname:"Bola Abdulra'Uf",slug:"lukman-bola-abdulra'uf",fullName:"Lukman Bola Abdulra'Uf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10357",title:"Drug Metabolism",subtitle:null,isOpenForSubmission:!1,hash:"3bd3ae5041cab45020555b49152b1ddc",slug:"drug-metabolism",bookSignature:"Katherine Dunnington",coverURL:"https://cdn.intechopen.com/books/images_new/10357.jpg",editedByType:"Edited by",editors:[{id:"232694",title:"Dr.",name:"Katherine",middleName:null,surname:"Dunnington",slug:"katherine-dunnington",fullName:"Katherine Dunnington"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10735",title:"Metformin",subtitle:"Pharmacology and Drug Interactions",isOpenForSubmission:!1,hash:"fee7e27a0fa000d000c459ff6e4b749e",slug:"metformin-pharmacology-and-drug-interactions",bookSignature:"Juber Akhtar, Usama Ahmad, Badruddeen and Mohammad Irfan Khan",coverURL:"https://cdn.intechopen.com/books/images_new/10735.jpg",editedByType:"Edited by",editors:[{id:"345595",title:"Prof.",name:"Juber",middleName:null,surname:"Akhtar",slug:"juber-akhtar",fullName:"Juber Akhtar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",isOpenForSubmission:!1,hash:"6d200cc031706a565b554fdb1c478901",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",bookSignature:"Rajesh Kumar Singh",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",editedByType:"Edited by",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:97,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"64762",doi:"10.5772/intechopen.82511",title:"Mechanism and Health Effects of Heavy Metal Toxicity in Humans",slug:"mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans",totalDownloads:10448,totalCrossrefCites:106,totalDimensionsCites:242,abstract:"Several heavy metals are found naturally in the earth crust and are exploited for various industrial and economic purposes. Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"57717",doi:"10.5772/intechopen.71923",title:"In Vitro Cytotoxicity and Cell Viability Assays: Principles, Advantages, and Disadvantages",slug:"in-vitro-cytotoxicity-and-cell-viability-assays-principles-advantages-and-disadvantages",totalDownloads:14810,totalCrossrefCites:77,totalDimensionsCites:156,abstract:"Cytotoxicity is one of the most important indicators for biological evaluation in vitro studies. In vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such as destruction of cell membranes, prevention of protein synthesis, irreversible binding to receptors etc. In order to determine the cell death caused by these damages, there is a need for cheap, reliable and reproducible short-term cytotoxicity and cell viability assays. Cytotoxicity and cell viability assays are based on various cell functions. A broad spectrum of cytotoxicity assays is currently used in the fields of toxicology and pharmacology. There are different classifications for these assays: (i) dye exclusion assays; (ii) colorimetric assays; (iii) fluorometric assays; and (iv) luminometric assays. Choosing the appropriate method among these assays is important for obtaining accurate and reliable results. When selecting the cytotoxicity and cell viability assays to be used in the study, different parameters have to be considered such as the availability in the laboratory where the study is to be performed, test compounds, detection mechanism, specificity, and sensitivity. In this chapter, information will be given about in vitro cytotoxicity and viability assays, these assays will be classified and their advantages and disadvantages will be emphasized. The aim of this chapter is to guide the researcher interested in this subject to select the appropriate assay for their study.",book:{id:"6310",slug:"genotoxicity-a-predictable-risk-to-our-actual-world",title:"Genotoxicity",fullTitle:"Genotoxicity - A Predictable Risk to Our Actual World"},signatures:"Özlem Sultan Aslantürk",authors:[{id:"211212",title:"Dr.",name:"Özlem Sultan",middleName:null,surname:"Aslantürk",slug:"ozlem-sultan-aslanturk",fullName:"Özlem Sultan Aslantürk"}]},{id:"66259",doi:"10.5772/intechopen.85270",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7576,totalCrossrefCites:58,totalDimensionsCites:152,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"40253",doi:"10.5772/50486",title:"Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development",slug:"lipid-nanoparticulate-drug-delivery-systems-a-revolution-in-dosage-form-design-and-development",totalDownloads:11291,totalCrossrefCites:22,totalDimensionsCites:105,abstract:null,book:{id:"2509",slug:"recent-advances-in-novel-drug-carrier-systems",title:"Recent Advances in Novel Drug Carrier Systems",fullTitle:"Recent Advances in Novel Drug Carrier Systems"},signatures:"Anthony A. Attama, Mumuni A. Momoh and Philip F. Builders",authors:[{id:"142947",title:"Prof.",name:"Anthony",middleName:null,surname:"Attama",slug:"anthony-attama",fullName:"Anthony Attama"}]},{id:"42016",doi:"10.5772/55187",title:"Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?",slug:"why-are-early-life-stages-of-aquatic-organisms-more-sensitive-to-toxicants-than-adults-",totalDownloads:3490,totalCrossrefCites:38,totalDimensionsCites:103,abstract:null,book:{id:"3408",slug:"new-insights-into-toxicity-and-drug-testing",title:"New Insights into Toxicity and Drug Testing",fullTitle:"New Insights into Toxicity and Drug Testing"},signatures:"Azad Mohammed",authors:[{id:"147061",title:"Dr.",name:"Azad",middleName:null,surname:"Mohammed",slug:"azad-mohammed",fullName:"Azad Mohammed"}]}],mostDownloadedChaptersLast30Days:[{id:"64762",title:"Mechanism and Health Effects of Heavy Metal Toxicity in Humans",slug:"mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans",totalDownloads:10456,totalCrossrefCites:107,totalDimensionsCites:242,abstract:"Several heavy metals are found naturally in the earth crust and are exploited for various industrial and economic purposes. Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"49459",title:"Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration",slug:"pharmacokinetics-of-drugs-following-iv-bolus-iv-infusion-and-oral-administration",totalDownloads:15480,totalCrossrefCites:16,totalDimensionsCites:24,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"Tarek A. Ahmed",authors:[{id:"175649",title:"Dr.",name:"Tarek A",middleName:null,surname:"Ahmed",slug:"tarek-a-ahmed",fullName:"Tarek A Ahmed"}]},{id:"29240",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:27175,totalCrossrefCites:28,totalDimensionsCites:58,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"66259",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7587,totalCrossrefCites:58,totalDimensionsCites:152,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:4130,totalCrossrefCites:16,totalDimensionsCites:32,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]}],onlineFirstChaptersFilter:{topicId:"19",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82962",title:"Pluralism Medical Treatment, Prevention, and Control of COVID-19 Infection and Its Long-Sufferings among the Older Adults in the Northeast of Thailand from 2019 to 2022",slug:"pluralism-medical-treatment-prevention-and-control-of-covid-19-infection-and-its-long-sufferings-amo",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.106339",abstract:"COVID-19 in 2019 has brought both changes and challenges to the world. This global pandemic has an impact on people of all age levels, especially older adults. In Thailand, older persons are at high risk of COVID-19 infection. They are included in the so-called 608 groups. The objective of this review article was to synthesize and present medical pluralism, the development of drugs from herbs, and projects conducted to treat, prevent, and control the infection and long sufferings of COVID-19. The review covers 10 studies, three projects produced at Mahasarakham University, Chaiyaphum Rajabhat University, and Khon Kaen University that were reviewed, synthesized, and analyzed. The results of the synthesis indicate that modern and Thai traditional medicine can help reduce the severity of the infection and long sufferings of COVID-19. The medical pluralism between modern and Thai traditional medicine is needed to remedy COVID-19 cases among the older adults in the Northeast of Thailand.",book:{id:"11690",title:"COVID-19 Drug Development - Recent Advances, New Perspectives, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11690.jpg"},signatures:"Pissamai Homchampa, Khemika Napattaradechanon, Parichat Yatniyom, Thawalrat Ratanasiri, Piyaporn Sansila, Thanawan Sirisuk, Thawalwong Ratanasiri and Amornrat Ratanasiri"},{id:"82353",title:"Pharmacovigilance of Biological Drugs",slug:"pharmacovigilance-of-biological-drugs",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.105520",abstract:"The use of biological drugs has significantly increased over the past decades and has allowed for the treatment of many life-threatening and chronic diseases. The patent expiration of biological innovative medicines enables copies of these drugs called biosimilars. The availability of biosimilars enhances competition, with the potential to improve patient access to biological medications and contribute to the financial sustainability of the healthcare systems. Unlike equivalent drugs, biosimilars are not identical but similar to their innovator products because of the differences in the manufacturing process, which is a biological process. However, they are considered comparable to their originators in safety, quality characteristics, biological activity, and efficacy. The regulatory procedures used for generic drugs cannot be applied for biosimilars, so they are subjected to rigorous characterization as well as comparative clinical studies. Since they are highly complex molecules produced from living cells, even small change in the production process can have major implications on their safety and effectiveness profile, causing a potential risk of immune-based adverse reactions. For all these reasons, for biological drugs, a robust long-term pharmacovigilance system is necessary. It is desirable that in the future, there are further guidance and resolution of the ongoing discussions on biosimilar labeling, naming, pharmacovigilance and interchangeability/substitution, to ensure the appropriate use of these drugs in clinical practice.",book:{id:"11679",title:"Pharmacovigilance and Regulations",coverURL:"https://cdn.intechopen.com/books/images_new/11679.jpg"},signatures:"Simona Guerzoni, Flavia Lo Castro, Carlo Baraldi, Giuliana Colella and Luca Pani"},{id:"82868",title:"Recent Strategies for Ocular Drug Delivery: Promises and Challenges",slug:"recent-strategies-for-ocular-drug-delivery-promises-and-challenges",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.106335",abstract:"Ocular diseases include various anterior and posterior segment diseases. Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers. The emerging nanoscience is playing an important role in the development of novel strategies for ocular disease management. Various active molecules have been designed to associate with nanocarriers to overcome ocular barriers and interact with certain ocular tissues. In this chapter, highlights will be made on barrier to intraocular delivery, general pathways for ocular absorption, and factors affecting intraocular bioavailability. The recent attempts of nanotechnology for treating anterior and posterior ocular diseases will be explored. This will include nanomicelles, nanoparticles, nanosuspensions, vesicular systems, in situ gel, dendrimers, contact lenses, implants, microneedles, and cell-based delivery systems. In addition, gene-based ocular delivery systems will be discussed. In this chapter, we will also provide a comprehensive overview of drug-device combinations used for ocular diseases such as glaucoma, dry eye disease, infections, and inflammations. Furthermore, drug delivery devices for ocular surgeries are discussed. Finally, challenges and future prospective of ocular delivery systems will be explored.",book:{id:"11688",title:"Advances in Drug Delivery Methods",coverURL:"https://cdn.intechopen.com/books/images_new/11688.jpg"},signatures:"Amal H. El-Kamel and Asmaa A. Ashour"},{id:"82727",title:"Mesoporous Silica Based Cancer Theranostic: A Modern Approach in Upcoming Medicine",slug:"mesoporous-silica-based-cancer-theranostic-a-modern-approach-in-upcoming-medicine",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.105447",abstract:"In case cancers are located deep inside the body and are very tough to diagnose, diagnostic tools like MRI/CT scans can be employed to detect these cancers. The major challenge in such cases is the delivery of MRI active agents or visualizing agents to the target site. In this context we will discuss different mesoporous nanoparticles that can be employed to target the tissue at a specific location, its functionalization to reach the target site (Folic acid), different simple dyes as well as specific dyes which offer theranostic functionality. The nanoparticles like mesoporous silica nanoparticles offer the possibility to load therapeutic and diagnostic agents. Its surface allow multiple functionalization and conjugations which offer target specific delivery of these agents. Moreover we will also overview different modern drug delivery inventions for offering theranostic application.",book:{id:"11688",title:"Advances in Drug Delivery Methods",coverURL:"https://cdn.intechopen.com/books/images_new/11688.jpg"},signatures:"Ajinkya Pote, Vikas Ahirrao and Vishal Pande"},{id:"82680",title:"Recent Pharmaceutical Developments in the Treatment of Cancer Using Nanosponges",slug:"recent-pharmaceutical-developments-in-the-treatment-of-cancer-using-nanosponges",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.105817",abstract:"Nanosponges are a class of nanoparticles characterized by their sponge-like surface that ensures high loading capacity. Cancer causes high mortality and requires precise treatment without harming the body. Hence, nanoparticles are required to target medications to tumor. Nanosponges may be synthesized from various polymers and metals, giving them distinct properties. The majority of polymer synthesis entails crosslinking, while metal synthesis entails the isolation of metal nanoparticles accompanied by their assembly into sponges. Nanosponges must be functionalized to precisely attack tumors. There are several patents on nanosponges synthesis and their use. Future trends in the usage of nanosponges include simultaneous distribution of several molecules and expanding the spectrum of use from medicinal delivery to substance encapsulation for a multitude of applications. As their usage in the pharmaceutical industry grows, more emphasis should be put on toxicity-related aspects induced by the near association of cell membrane and nanosponge resulting in intracellular dissolution or reactive oxygen species (ROS) generation, which in turn damages various cellular components. Many techniques have been created to reduce toxicity, including functionalization with various materials such as antioxidants, polymers and altering nanosponges composition. As the application of nanosponges increases in many industries, the phenomenon related to toxicity must be further explored through research.",book:{id:"11688",title:"Advances in Drug Delivery Methods",coverURL:"https://cdn.intechopen.com/books/images_new/11688.jpg"},signatures:"Kapil Gore, Sankha Bhattacharya and Bhupendra G. Prajapati"},{id:"82523",title:"Trypan Blue Exclusion Assay, Neutral Red, Acridine Orange and Propidium Lodide",slug:"trypan-blue-exclusion-assay-neutral-red-acridine-orange-and-propidium-lodide",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.105699",abstract:"Cytotoxicity and cell viability assessments are very important parameters that are widely used in fundamental research and drug development to determine the safety profile of toxic compounds. These assays measure the degree to which a substance can cause toxic damage to cells or cell death. There are different assays that have been employed to determine the cytotoxicity of substances. These assays either determine enzymatic function, cell viability, mitochondrial activity, lipid metabolism, cell proliferation and/or cell death. These assays entail use of different kinds of dyes such as trypan blue exclusion dye, neutral red, acridine orange and propidium iodide to stain the cells. Trypan blue dye permeates compromised cell membrane to stain necrotic cells. However, this can lead to false positive and false negative results as it does not provide information on sub-lethal injury. As a result, neutral red and acridine orange can be used as counterstains for trypan blue to stain the lysosome of live cells. Acridine orange can also be used to stain nucleic acids in living cells and is usually co-stained with propidium iodide or ethidium bromide. This is because propidium iodide permeates only compromised plasma membrane thus co-staining cells with these dyes can provide vital information that can be used to differentiate between live and dead cells.",book:{id:"11678",title:"Cytotoxicity",coverURL:"https://cdn.intechopen.com/books/images_new/11678.jpg"},signatures:"Arinzechukwu Ude, Kaiyven Afi-Leslie, Kelechi Okeke and Emmanuel Ogbodo"}],onlineFirstChaptersTotal:55},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"July 20th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:14,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",institutionString:"Kafkas University",institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"319576",title:"Prof.",name:"Nikolay",middleName:null,surname:"Boyadjiev",slug:"nikolay-boyadjiev",fullName:"Nikolay Boyadjiev",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v4b3cQAA/Profile_Picture_2022-06-07T08:30:58.jpeg",institutionString:null,institution:{name:"Medical University Plovdiv",institutionURL:null,country:{name:"Bulgaria"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:"Spanish National Research Council",institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. El-Esawi",profilePictureURL:"https://mts.intechopen.com/storage/users/191770/images/system/191770.jpeg",institutionString:null,institution:{name:"Tanta University",institutionURL:null,country:{name:"Egypt"}}},{id:"247858",title:"Dr.",name:"Saddam",middleName:null,surname:"Hussain",slug:"saddam-hussain",fullName:"Saddam Hussain",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSF2aQAG/Profile_Picture_1625658281836",institutionString:null,institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}]}]},overviewPageOFChapters:{paginationCount:10,paginationItems:[{id:"82858",title:"Corporate Social Responsibility a Case of the Provision of Recreational Facilities",doi:"10.5772/intechopen.105608",signatures:"Peter Musa Wash, Shida Irwana Omar, Badaruddin Mohamed and Mohd Ismail Isa",slug:"corporate-social-responsibility-a-case-of-the-provision-of-recreational-facilities",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82786",title:"Discussion of Purchasing Virtual Digital Nature and Tourism",doi:"10.5772/intechopen.105869",signatures:"Hiroko Oe and Yasuyuki Yamaoka",slug:"discussion-of-purchasing-virtual-digital-nature-and-tourism",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82289",title:"Consumer Culture and Abundance of Choices: Having More, Feeling Blue",doi:"10.5772/intechopen.105607",signatures:"Ondřej Roubal",slug:"consumer-culture-and-abundance-of-choices-having-more-feeling-blue",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}}]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"12141",title:"Leadership - Advancing Great Leadership Practices and Good Leaders",coverURL:"https://cdn.intechopen.com/books/images_new/12141.jpg",hash:"85f77453916f1d80d80d88ee4fd2f2d1",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 1st 2022",isOpenForSubmission:!0,editors:[{id:"420133",title:"Dr.",name:"Joseph",surname:"Crawford",slug:"joseph-crawford",fullName:"Joseph Crawford"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12139",title:"Global Market and Trade",coverURL:"https://cdn.intechopen.com/books/images_new/12139.jpg",hash:"fa34af07c3a9657fa670404202f8cba5",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 21st 2022",isOpenForSubmission:!0,editors:[{id:"243649",title:"Dr.Ing.",name:"Ireneusz",surname:"Miciuła",slug:"ireneusz-miciula",fullName:"Ireneusz Miciuła"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:10,paginationItems:[{id:"82858",title:"Corporate Social Responsibility a Case of the Provision of Recreational Facilities",doi:"10.5772/intechopen.105608",signatures:"Peter Musa Wash, Shida Irwana Omar, Badaruddin Mohamed and Mohd Ismail Isa",slug:"corporate-social-responsibility-a-case-of-the-provision-of-recreational-facilities",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82786",title:"Discussion of Purchasing Virtual Digital Nature and Tourism",doi:"10.5772/intechopen.105869",signatures:"Hiroko Oe and Yasuyuki Yamaoka",slug:"discussion-of-purchasing-virtual-digital-nature-and-tourism",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82289",title:"Consumer Culture and Abundance of Choices: Having More, Feeling Blue",doi:"10.5772/intechopen.105607",signatures:"Ondřej Roubal",slug:"consumer-culture-and-abundance-of-choices-having-more-feeling-blue",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82395",title:"Toward a Better Understanding of Green Human Resource Management’s Impact on Green Competitive Advantage: A Conceptual Model",doi:"10.5772/intechopen.105528",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"toward-a-better-understanding-of-green-human-resource-management-s-impact-on-green-competitive-advan",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82269",title:"CSR Reporting and Blockchain Technology",doi:"10.5772/intechopen.105512",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Piyachart Phiromswad",slug:"csr-reporting-and-blockchain-technology",totalDownloads:31,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82270",title:"From Corporate Social Opportunity to Corporate Social Responsibility",doi:"10.5772/intechopen.105445",signatures:"Brian Bolton",slug:"from-corporate-social-opportunity-to-corporate-social-responsibility",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82339",title:"Green Human Resource Management: An Exploratory Study from Moroccan ISO 14001 Certified Companies",doi:"10.5772/intechopen.105565",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"green-human-resource-management-an-exploratory-study-from-moroccan-iso-14001-certified-companies",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82194",title:"CSR and Female Directors: A Review and Future Research Agenda",doi:"10.5772/intechopen.105112",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Sirimon Treepongkaruna",slug:"csr-and-female-directors-a-review-and-future-research-agenda",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},subseriesFiltersForOFChapters:[{caption:"Marketing",value:88,count:2,group:"subseries"},{caption:"Business and Management",value:86,count:8,group:"subseries"}],publishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"10840",title:"Benzimidazole",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10840.jpg",slug:"benzimidazole",publishedDate:"July 13th 2022",editedByType:"Edited by",bookSignature:"Pravin Kendrekar and Vinayak Adimule",hash:"e28c770013e7a8dd0fc37aea6aa9def8",volumeInSeries:34,fullTitle:"Benzimidazole",editors:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",slug:"starch-evolution-and-recent-advances",publishedDate:"June 28th 2022",editedByType:"Edited by",bookSignature:"Martins Ochubiojo Emeje",hash:"f197f6062c1574a9a90e50a369271bcf",volumeInSeries:33,fullTitle:"Starch - Evolution and Recent Advances",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",institutionURL:null,country:{name:"Nigeria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",slug:"essential-oils-advances-in-extractions-and-biological-applications",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",hash:"742e6cae3a35686f975edc8d7f9afa94",volumeInSeries:32,fullTitle:"Essential Oils - Advances in Extractions and Biological Applications",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira",profilePictureURL:"https://mts.intechopen.com/storage/users/195290/images/system/195290.png",institutionString:"Museu Paraense Emílio Goeldi",institution:{name:"Museu Paraense Emílio Goeldi",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",slug:"protein-detection",publishedDate:"June 23rd 2022",editedByType:"Edited by",bookSignature:"Yusuf Tutar and Lütfi Tutar",hash:"2f1c0e4e0207fc45c936e7d22a5369c4",volumeInSeries:31,fullTitle:"Protein Detection",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",institutionString:"University of Health Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"2c628f4757f9639a4450728d839a7842",volumeInSeries:30,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",slug:"hydrolases",publishedDate:"June 15th 2022",editedByType:"Edited by",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",hash:"4e868cde273d65a7ff54b1817d640629",volumeInSeries:29,fullTitle:"Hydrolases",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider",profilePictureURL:"https://mts.intechopen.com/storage/users/110708/images/system/110708.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:14}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:9},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:30,paginationItems:[{id:"425474",title:"Mr.",name:"Jasper",middleName:"Okoro Godwin",surname:"Okoro Godwin Elechi",slug:"jasper-okoro-godwin-elechi",fullName:"Jasper Okoro Godwin Elechi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/425474/images/19990_n.jpg",biography:"Mr. Elechi is an innovative and passionate food professional and educator who can collaborate across boundaries with an integrated aspiration of innovation to provide good, sustainable, and healthy food solutions that promote human health and conserve planetary health. He has a special interest in innovative food product development, nutrition, indigenous food products, biotechnology, bioeconmy, sustainable global food systems transformation, food safety Nanotechnology, and Nanomaterials. He has carried out independent research and publications in these areas. He possesses comprehensive knowledge and technical know-how on nutritional formulation and production of healthy and sustainable foods from locally available underutilized Cereal-Legume crops for combating food security and malnutrition in developing communities.",institutionString:null,institution:null},{id:"307387",title:"Dr.",name:"Cecilia",middleName:null,surname:"Camporeale",slug:"cecilia-camporeale",fullName:"Cecilia Camporeale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Agency For New Technologies, Energy and Sustainable Economic Development",country:{name:"Italy"}}},{id:"296882",title:"Dr.",name:"Mario",middleName:null,surname:"Jorizzo",slug:"mario-jorizzo",fullName:"Mario Jorizzo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Agency For New Technologies, Energy and Sustainable Economic Development",country:{name:"Italy"}}},{id:"307388",title:"Dr.",name:"ROBERTO",middleName:null,surname:"DEL CIELLO",slug:"roberto-del-ciello",fullName:"ROBERTO DEL CIELLO",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Agency For New Technologies, Energy and Sustainable Economic Development",country:{name:"Italy"}}},{id:"437647",title:"M.Sc.",name:"Fernando",middleName:null,surname:"Teixeira",slug:"fernando-teixeira",fullName:"Fernando Teixeira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"423338",title:"Dr.",name:"Harjeet",middleName:null,surname:"Singh",slug:"harjeet-singh",fullName:"Harjeet Singh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Chitkara University",country:{name:"India"}}},{id:"443635",title:"Dr.",name:"Suruchi",middleName:null,surname:"Jindal",slug:"suruchi-jindal",fullName:"Suruchi Jindal",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Punjab Agricultural University",country:{name:"India"}}},{id:"426265",title:"Mrs.",name:"Inonge",middleName:null,surname:"Chibua",slug:"inonge-chibua",fullName:"Inonge Chibua",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Botswana",country:{name:"Botswana"}}},{id:"426266",title:"Ms.",name:"Mesha",middleName:null,surname:"Mbisana",slug:"mesha-mbisana",fullName:"Mesha Mbisana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Botswana",country:{name:"Botswana"}}},{id:"426264",title:"Mr.",name:"Samuel",middleName:null,surname:"Raditloko",slug:"samuel-raditloko",fullName:"Samuel Raditloko",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Botswana",country:{name:"Botswana"}}},{id:"426394",title:"Dr.",name:"Mags",middleName:null,surname:"Adams",slug:"mags-adams",fullName:"Mags Adams",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Central Lancashire",country:{name:"United Kingdom"}}},{id:"441182",title:"Dr.",name:"Neil",middleName:null,surname:"Wilson",slug:"neil-wilson",fullName:"Neil Wilson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Central Lancashire",country:{name:"United Kingdom"}}},{id:"425171",title:"Ph.D. Student",name:"Tanya",middleName:null,surname:"Zerbian",slug:"tanya-zerbian",fullName:"Tanya Zerbian",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Central Lancashire",country:{name:"Cyprus"}}},{id:"424714",title:"Prof.",name:"Elke",middleName:null,surname:"Stedefeldt",slug:"elke-stedefeldt",fullName:"Elke Stedefeldt",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",country:{name:"Brazil"}}},{id:"425244",title:"Dr.",name:"Rayane",middleName:"Stephanie Gomes",surname:"Stephanie Gomes De Freitas",slug:"rayane-stephanie-gomes-de-freitas",fullName:"Rayane Stephanie Gomes De Freitas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",country:{name:"Brazil"}}},{id:"424688",title:"Dr.",name:"Bart",middleName:null,surname:"de Steenhuijsen Piters",slug:"bart-de-steenhuijsen-piters",fullName:"Bart de Steenhuijsen Piters",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"429404",title:"Dr.",name:"Emma",middleName:null,surname:"Termeer",slug:"emma-termeer",fullName:"Emma Termeer",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"429407",title:"Dr.",name:"Herman",middleName:null,surname:"Brouwer",slug:"herman-brouwer",fullName:"Herman Brouwer",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"429406",title:"Dr.",name:"Hubert",middleName:null,surname:"Fonteijn",slug:"hubert-fonteijn",fullName:"Hubert Fonteijn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Wageningen University & Research",country:{name:"Netherlands"}}},{id:"427504",title:"Dr.",name:"Kriengsak",middleName:null,surname:"Chareonwongsak",slug:"kriengsak-chareonwongsak",fullName:"Kriengsak Chareonwongsak",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"423333",title:"Ph.D. Student",name:"Shivani",middleName:null,surname:"Sood",slug:"shivani-sood",fullName:"Shivani Sood",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"452297",title:"Mr.",name:"Cornelius",middleName:null,surname:"Smah Adamu",slug:"cornelius-smah-adamu",fullName:"Cornelius Smah Adamu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"452296",title:"Mr.",name:"Ikechukwu",middleName:null,surname:"U. Nwiyi",slug:"ikechukwu-u.-nwiyi",fullName:"Ikechukwu U. Nwiyi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"423395",title:"Assistant Prof.",name:"Adane",middleName:null,surname:"Atara Debessa",slug:"adane-atara-debessa",fullName:"Adane Atara Debessa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"426267",title:"Mr.",name:"Banyaladzi",middleName:null,surname:"Paphane",slug:"banyaladzi-paphane",fullName:"Banyaladzi Paphane",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"483388",title:"Dr.",name:"Berhanu",middleName:null,surname:"Denu",slug:"berhanu-denu",fullName:"Berhanu Denu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"483387",title:"Dr.",name:"Degefa",middleName:null,surname:"Tolossa",slug:"degefa-tolossa",fullName:"Degefa Tolossa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"426059",title:"Dr.",name:"Dikabo",middleName:null,surname:"Mogopodi",slug:"dikabo-mogopodi",fullName:"Dikabo Mogopodi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"422909",title:"Dr.",name:"Dorcas Stella",middleName:null,surname:"Shumba",slug:"dorcas-stella-shumba",fullName:"Dorcas Stella Shumba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"429405",title:"Dr.",name:"Deborah",middleName:null,surname:"Bakker",slug:"deborah-bakker",fullName:"Deborah Bakker",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"23",type:"subseries",title:"Computational Neuroscience",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11419,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",slug:"asim-bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",slug:"joao-luis-garcia-rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:0,paginationItems:[]},publishedBooks:{paginationCount:2,paginationItems:[{type:"book",id:"9525",title:"Insights Into Drug Resistance in Staphylococcus aureus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9525.jpg",slug:"insights-into-drug-resistance-in-staphylococcus-aureus",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Amjad Aqib",hash:"98bb6c1ddb067da67185c272f81c0a27",volumeInSeries:10,fullTitle:"Insights Into Drug Resistance in Staphylococcus aureus",editors:[{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9614",title:"Advances in Candida albicans",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",editedByType:"Edited by",bookSignature:"Xinhui Wang",hash:"31d6882518ca749b12715266eed0a018",volumeInSeries:9,fullTitle:"Advances in Candida albicans",editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/296531/images/system/296531.jpg",institutionString:"Qinghai Normal University",institution:{name:"University of Luxembourg",institutionURL:null,country:{name:"Luxembourg"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"7",title:"Bioinformatics and Medical Informatics",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine"},{id:"8",title:"Bioinspired Technology and Biomechanics",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation"},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/169494",hash:"",query:{},params:{id:"169494"},fullPath:"/profiles/169494",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()