Analysis of volatile organic compounds (VOCs) in exhaled breath is non-invasive method and appears as a promising tool for metabolic monitoring. Diabetes is a complex syndrome, metabolic diseases that is characterized by hyperglycemia associated with major changes in lipids and proteins. The pathophysiology of the link between diabetes, hypertension, inflammatory syndrome and oxidative stress is complex. We conducted a study and applied quantitative analysis of exhaled ethylene and ammonia in patients with type 2 diabetes mellitus (T2DM) and a healthy control group. For breath gas analysis, a very sensitive CO2 laser photoacoustic spectroscopy (CO2LPAS) was applied. The concentration of exhaled VOCs differed between T2DM patients and healthy group, in particular, T2DM patients exhaled significantly higher amounts of ethylene and ammonia compared to healthy control group. The data obtained by the CO2LPAS system revealing that the increased breath VOCs has a close relationship with high glucose levels and with healthy complications.
Part of the book: Type 2 Diabetes