Mechanical properties for the weakened AGARD 445.6 wing.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5304",leadTitle:null,fullTitle:"Herpesviridae",title:"Herpesviridae",subtitle:null,reviewType:"peer-reviewed",abstract:"Herpesviruses are unique among viruses as they encode for a complex self-regulatory system, aggressively invade and persist in the host, evade immune defense, alter all regulatory mechanisms of the macroorganism and modify the replication of heterologous viruses. Environmental factors influence these unconventional relationships. Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors. This book is intended to give an overview on selected clinical hot topics: herpes simplex virus encephalitis, persistent infection in the gingiva, thymidine kinase gene expression causing male infertility, and pharmaceutical reactivation of Epstein-Barr virus for oncolysis. Immune evasion mechanisms and new ways to formulate vaccines are exhaustively reviewed. Finally, a surprise: bovine herpesviruses could serve as models to study the pathomechanism of herpesviruses.",isbn:"978-953-51-2611-9",printIsbn:"978-953-51-2610-2",pdfIsbn:"978-953-51-4185-3",doi:"10.5772/61923",price:119,priceEur:129,priceUsd:155,slug:"herpesviridae",numberOfPages:272,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"8fbc7434e4f188915ad840a39bc80626",bookSignature:"Jozsef Ongradi",publishedDate:"September 7th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5304.jpg",numberOfDownloads:14295,numberOfWosCitations:20,numberOfCrossrefCitations:15,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:25,numberOfDimensionsCitationsByBook:4,hasAltmetrics:0,numberOfTotalCitations:60,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 19th 2015",dateEndSecondStepPublish:"December 10th 2015",dateEndThirdStepPublish:"March 29th 2016",dateEndFourthStepPublish:"June 27th 2016",dateEndFifthStepPublish:"July 27th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"36151",title:"Dr.",name:"Joseph",middleName:null,surname:"Ongrádi",slug:"joseph-ongradi",fullName:"Joseph Ongrádi",profilePictureURL:"https://mts.intechopen.com/storage/users/36151/images/3376_n.jpg",biography:"Joseph Ongrádi graduated as MD at the Semmelweis University of Medicine, Budapest, Hungary, in 1976. At this university, he obtained his PhD at the Institute of Microbiology. He is a board-certified medical microbiologist and clinical biologist and has habilitation in medical microbiology. Between 1998 and 2005, he was the Head of Microbiology Laboratory, Department of Dermato-Venereology; between 2005 and 2010, he was the head of the Immunovirology Laboratory, Department of Public Health, and he returned to the Department of Medical Microbiology in 2011. His interests include latency, reactivation, interaction of herpesviruses, adenoviruses, and retroviruses. He described the role of Roseoloviruses in skin diseases, multiple sclerosis and AIDS, and two bacterium species as sexually transmitted infections and isolated the first Adenovirus from Felidae in the feline AIDS model.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Semmelweis University",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1046",title:"Infectious Diseases",slug:"infectious-diseases"}],chapters:[{id:"51751",title:"Introductory Chapter: Unconventional Philosophy of Herpesvirus Infections",doi:"10.5772/64818",slug:"introductory-chapter-unconventional-philosophy-of-herpesvirus-infections",totalDownloads:1211,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Joseph Ongrádi",downloadPdfUrl:"/chapter/pdf-download/51751",previewPdfUrl:"/chapter/pdf-preview/51751",authors:[{id:"36151",title:"Dr.",name:"Joseph",surname:"Ongrádi",slug:"joseph-ongradi",fullName:"Joseph Ongrádi"}],corrections:null},{id:"51604",title:"Herpes Simplex Virus Type 1 at the Central Nervous System",doi:"10.5772/64130",slug:"herpes-simplex-virus-type-1-at-the-central-nervous-system",totalDownloads:2160,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Herpes simplex virus type 1 (HSV‐1) is a ubiquitous and neurotropic pathogen and is the most common cause of acute sporadic encephalitis in humans. This virus is characterized by establishing a persistent latent infection in neurons of its hosts for life. The pathogenic mechanisms of HSV‐1 at the central nervous system (CNS) are not completely elucidated. Besides, evidences suggest that HSV‐1 establish latency in the CNS in humans and that this condition would not be harmless, especially in people whose immune system is declined. This trait has been strongly suggested as a risk factor for the development of neurodegenerative pathologies such as Alzheimer's disease. Currently, it is unclear whether a neuron, which undergoes viral reactivation and produces infectious particles, survives and resumes latency, loses functionality, or is killed. These data highlight the need for more studies at cellular and molecular levels to understand the strategies used by the virus and the host cells during both productive and latent infection. The present chapter discusses the current investigations about HSV‐1 infection at the CNS and the potential risk of neuronal dysfunction and chronic neurological diseases.",signatures:"Carola Otth, Francisca Acuña‐Hinrichsen, Luis Leyton, Carolina\nMartin and Margarita I. Concha",downloadPdfUrl:"/chapter/pdf-download/51604",previewPdfUrl:"/chapter/pdf-preview/51604",authors:[{id:"184195",title:"Ph.D.",name:"Carola",surname:"Otth",slug:"carola-otth",fullName:"Carola Otth"},{id:"184196",title:"MSc.",name:"Francisca",surname:"Acuña-Hinrichsen",slug:"francisca-acuna-hinrichsen",fullName:"Francisca Acuña-Hinrichsen"},{id:"184197",title:"BSc.",name:"Luis",surname:"Leyton",slug:"luis-leyton",fullName:"Luis Leyton"},{id:"184198",title:"Dr.",name:"Margarita",surname:"Concha",slug:"margarita-concha",fullName:"Margarita Concha"},{id:"187592",title:"Dr.",name:"Carolina",surname:"Martin",slug:"carolina-martin",fullName:"Carolina Martin"}],corrections:null},{id:"51338",title:"Herpesviruses in Periapical Pathoses: An Updated Systematic Review",doi:"10.5772/64004",slug:"herpesviruses-in-periapical-pathoses-an-updated-systematic-review",totalDownloads:1481,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evaluation, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",signatures:"Aleksandar Jakovljević, Miroslav Andrić, Aleksandra Knežević,\nKatarina Beljić-Ivanović, Maja Miletić, Tanja Jovanović, Ljiljana Kesić\nand Jelena Milašin",downloadPdfUrl:"/chapter/pdf-download/51338",previewPdfUrl:"/chapter/pdf-preview/51338",authors:[{id:"49081",title:"Dr.",name:"Miroslav",surname:"Andric",slug:"miroslav-andric",fullName:"Miroslav Andric"},{id:"64273",title:"Dr.",name:"Jelena",surname:"Milašin",slug:"jelena-milasin",fullName:"Jelena Milašin"},{id:"183895",title:"Dr.",name:"Aleksandar",surname:"Jakovljevic",slug:"aleksandar-jakovljevic",fullName:"Aleksandar Jakovljevic"},{id:"184099",title:"Prof.",name:"Aleksandra",surname:"Knezevic",slug:"aleksandra-knezevic",fullName:"Aleksandra Knezevic"},{id:"184100",title:"Dr.",name:"Katarina",surname:"Beljic-Ivanovic",slug:"katarina-beljic-ivanovic",fullName:"Katarina Beljic-Ivanovic"},{id:"184101",title:"Dr.",name:"Maja",surname:"Miletic",slug:"maja-miletic",fullName:"Maja Miletic"},{id:"184104",title:"Prof.",name:"Tanja",surname:"Jovanovic",slug:"tanja-jovanovic",fullName:"Tanja Jovanovic"},{id:"184105",title:"Prof.",name:"Ljiljana",surname:"Kesic",slug:"ljiljana-kesic",fullName:"Ljiljana Kesic"}],corrections:null},{id:"51491",title:"Ectopic Expression of Human Herpesvirus 1 Thymidine Kinase Induces Male Infertility",doi:"10.5772/64390",slug:"ectopic-expression-of-human-herpesvirus-1-thymidine-kinase-induces-male-infertility",totalDownloads:1056,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The herpesvirus family comprises several widespread infectious pathogens. They infect a variety of animal hosts, including humans and cause complex clinical outcomes. Recently, the possible correlation between genital infection by human herpesviruses (HHVs) and male infertility has attracted considerable attention. In this chaper, we investigated the mechanism of HHV‐1‐induced infertility in transgenic (Tg) rats and its possible correlation with infertility in human males. Ectopic expression of HHV‐1 thymidine kinase (TK) in the testis of Tg rats increased male infertility. In addition, truncated TK proteins were found in postmeiotic spermatids of Tg rat testis, leading to progressive degeneration of germ cells and vacuolization of the seminiferous epithelium. These findings suggest the possibility that a similar process occurs within HHV‐infected human germ cells.",signatures:"Mo Chen, Li‐yi Cai, Takako Kato and Yukio Kato",downloadPdfUrl:"/chapter/pdf-download/51491",previewPdfUrl:"/chapter/pdf-preview/51491",authors:[{id:"99373",title:"Prof.",name:"Yukio",surname:"Kato",slug:"yukio-kato",fullName:"Yukio Kato"},{id:"99403",title:"Dr.",name:"Takako",surname:"Kato",slug:"takako-kato",fullName:"Takako Kato"},{id:"188605",title:"Dr.",name:"Mo",surname:"Chen",slug:"mo-chen",fullName:"Mo Chen"},{id:"188606",title:"Dr.",name:"Li-Yi",surname:"Cai",slug:"li-yi-cai",fullName:"Li-Yi Cai"}],corrections:null},{id:"51597",title:"Immune Evasion by Herpes Simplex Viruses",doi:"10.5772/64128",slug:"immune-evasion-by-herpes-simplex-viruses",totalDownloads:1615,totalCrossrefCites:5,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Infection with herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) is extremely frequent in the human population, as well as recurrent reactivations due to lifelong infection. Infection and persistence of HSVs within healthy individuals likely results as a consequence of numerous molecular determinants evolved by these pathogens to escape both immediate and long-term host antiviral mechanisms. Indeed, HSVs harbor an arsenal of proteins that confer them stealth by negatively modulating immune function. Consequently, these viruses perpetuate within the host, altogether silently shedding onto other individuals. In this chapter, we discuss HSV determinants that interfere with cellular antiviral factors, as well as viral determinants that hamper innate and adaptive immune components intended to control such microbes. The identification of HSV evasion molecules that modulate the immune system, as well as the understanding of their mechanisms of action, should facilitate the design of novel prophylactic and therapeutic strategies to overcome infection and disease elicited by these viruses. This chapter is intended to provide an overview of the evasion mechanisms evolved by herpes simplex viruses to escape numerous host antiviral mediators.",signatures:"Angello R. Retamal-Díaz, Eduardo Tognarelli, Alexis M. Kalergis,\nSusan M. Bueno and Pablo A. González",downloadPdfUrl:"/chapter/pdf-download/51597",previewPdfUrl:"/chapter/pdf-preview/51597",authors:[{id:"182617",title:"Dr.",name:"Pablo",surname:"Gonzalez",slug:"pablo-gonzalez",fullName:"Pablo Gonzalez"},{id:"183529",title:"BSc.",name:"Eduardo",surname:"Tognarelli",slug:"eduardo-tognarelli",fullName:"Eduardo Tognarelli"},{id:"183530",title:"MSc.",name:"Angello",surname:"Retamal-Díaz",slug:"angello-retamal-diaz",fullName:"Angello Retamal-Díaz"},{id:"187559",title:"Dr.",name:"Susan",surname:"Bueno",slug:"susan-bueno",fullName:"Susan Bueno"},{id:"187560",title:"Dr.",name:"Alexis",surname:"Kalergis",slug:"alexis-kalergis",fullName:"Alexis Kalergis"}],corrections:null},{id:"51911",title:"Review: Biological and Pharmacological Basis of Cytolytic Viral Activation in EBV-Associated Nasopharyngeal Carcinoma",doi:"10.5772/64738",slug:"review-biological-and-pharmacological-basis-of-cytolytic-viral-activation-in-ebv-associated-nasophar",totalDownloads:1957,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Epstein-Barr virus (EBV) infection contributes to the development of different types of human malignancies, especially nasopharyngeal carcinoma. As a herpesvirus, EBV can establish two major modes of virus-cell interactions: a latent or a lytic infection. Latent infection is prevalent in the vast majority of malignant cells in EBV-related malignancies. Inducing a switch from latent to lytic infection in a substantial fraction of malignant cells has long been considered as a potentially interesting therapeutic approach. Therapeutic benefits are expected from (1) the cytotoxic or cytostatic effects of viral products expressed in the context of the lytic cycle; (2) expression of viral enzymes capable of metabolizing pro-drugs selectively inside these cells and (3) broadening the expression spectrum of antigenic viral proteins. In this chapter, addressing non EBV-specialized readers, we first summarize the main aspects of EBV biology with emphasis on the cellular mechanisms known to control latent and lytic infections. Then, we outline the basic principles and requirements of cytolytic EBV activation performed with a therapeutic intent. Finally, we review the main categories of pharmacological agents reported to be active in the switch from latent to lytic infection, including drugs used for conventional anti-tumour chemotherapy, histone-deacetylase inhibitors and various miscellaneous compounds.",signatures:"Natalie Oker, Nikiforos-Ioannis Kapetanakis and Pierre Busson",downloadPdfUrl:"/chapter/pdf-download/51911",previewPdfUrl:"/chapter/pdf-preview/51911",authors:[{id:"183209",title:"D.Sc.",name:"Pierre",surname:"Busson",slug:"pierre-busson",fullName:"Pierre Busson"}],corrections:null},{id:"51617",title:"Herpes Simplex Virus 1 and 2 Vaccine Design: What can we Learn from the Past?",doi:"10.5772/64447",slug:"herpes-simplex-virus-1-and-2-vaccine-design-what-can-we-learn-from-the-past-",totalDownloads:1621,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"This chapter is devoted to the topics of not yet marketed HSV vaccine, which is still in the focus of interest, especially from the point of immunotherapeutic use. To understand the principles of vaccination strategies (prophylactic and/or immunotherapeutic), the pathogenesis of herpes simplex virus 1 (HSV-1) and/or HSV-2 infections in animal models is briefly outlined. Even when both herpesviruses may spread via bloodstream, which is especially true in the immunocompromised host, the main route of their transmission is along peripheral nerves. Both viruses establish latency in ganglion cells, and after reactivation, they spread along axons back to the site of primary infection. Since neither the establishment of latency nor its reactivation can be fully controlled by virus-neutralizing antibodies, the outcome of immune response greatly depends on the activity of cytotoxic CD8+ T lymphocytes. The majority of important antigenic epitopes is located in envelope glycoproteins (such as gB, gD, gE, gC and gG) that are related to virus adsorption and penetration into susceptible cells. The HSV-1 and/or HSV-2 experimental vaccines designed so far were either purified virion products derived from infected cells (subunit vaccines), purified recombinant immunogenic herpes simplex virus HSV-coded proteins (especially gD), and/or attenuated live viruses lacking some of virulence tools (such as gH and/or gE). We bring a comprehensive overview of the efficacy of experimental HSV-1/HSV-2 vaccines and discuss our own data. In conclusion, we believe in the continued demand of HSV-1 and HSV-2 vaccines, at least for their immunotherapeutic use, suggesting unified evaluation criteria for clinical trials to reach consent at their interpretation.",signatures:"Vladimíra Ďurmanová, Marian Adamkov and Július Rajčáni",downloadPdfUrl:"/chapter/pdf-download/51617",previewPdfUrl:"/chapter/pdf-preview/51617",authors:[{id:"181773",title:"Emeritus Prof.",name:"Julius",surname:"Rajčáni",slug:"julius-rajcani",fullName:"Julius Rajčáni"},{id:"185924",title:"Prof.",name:"Marian",surname:"Adamkov",slug:"marian-adamkov",fullName:"Marian Adamkov"},{id:"186238",title:"Associate Prof.",name:"Vladimira",surname:"Ďurmanová",slug:"vladimira-durmanova",fullName:"Vladimira Ďurmanová"}],corrections:null},{id:"50493",title:"Herpesvirus in Bovines: Importance of Bovine Herpesvirus Type 1",doi:"10.5772/63157",slug:"herpesvirus-in-bovines-importance-of-bovine-herpesvirus-type-1",totalDownloads:1865,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The chapter aims at providing readers with the overview of the herpesvirus infection in bovines. It includes the detailed etiology of the infection, discussing the virus characteristics, virus structure, genome, viral proteins, types and subtypes of the virus. Then, the chapter discusses the transmission and pathogenesis of the virus, which are very important as they help to control the virus spread, viral latency and clinical signs observed in the affected animals. Later, the chapter discusses the diagnosis of herpesvirus infection in bovines to help the readers to gain knowledge about the techniques used earlier and nowadays for the diagnosis of the infection. Then, the chapter provides information on the procedures to be adopted for the prevention and control of the infection in bovines. Thus, the chapter provides complete information about the herpesvirus infection in bovines.",signatures:"Gurpreet Kaur and Mudit Chandra",downloadPdfUrl:"/chapter/pdf-download/50493",previewPdfUrl:"/chapter/pdf-preview/50493",authors:[{id:"183506",title:"Dr.",name:"Gurpreet",surname:"Kaur",slug:"gurpreet-kaur",fullName:"Gurpreet Kaur"},{id:"185854",title:"Dr.",name:"Mudit",surname:"Chandra",slug:"mudit-chandra",fullName:"Mudit Chandra"}],corrections:null},{id:"51229",title:"Latency of Bovine Herpesvirus 1 (BoHV-1) in Sensory Neurons",doi:"10.5772/63750",slug:"latency-of-bovine-herpesvirus-1-bohv-1-in-sensory-neurons",totalDownloads:1334,totalCrossrefCites:3,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Bovine herpesvirus 1 (BoHV-1) is an important pathogen of cattle and cofactor for bovine respiratory disease, a polymicrobial disease. Acute infection of cattle leads to abundant expression of lytic cycle viral genes, high levels of virus shedding, and clinical symptoms. Following acute infection, lifelong latency is established in sensory neurons. Only the latency-related (LR) gene locus, which encodes at least two micro-RNAs and several proteins, is abundantly expressed in latently infected neurons. Increased corticosteroids, due to external stressors, disrupt the maintenance of latency and increase the incidence of reactivation from latency, which is crucial for virus transmission. For example, calves latently infected with BoHV-1 consistently reactivate from latency following a single intravenous (IV) injection of the synthetic corticosteroid dexamethasone. In contrast to wild-type BoHV-1, an LR-mutant virus that has three in-frame stop codons at the amino terminus of the first open reading frame in the LR gene (ORF2) does not reactivate from latency following dexamethasone treatment. The ability of dexamethasone to initiate BoHV-1 reactivation from latency in calves makes it an attractive model to identify early events that occur during reactivation from latency. Viral and cellular factors that regulate the BoHV-1 latency-reactivation cycle are discussed in this review.",signatures:"Clinton Jones",downloadPdfUrl:"/chapter/pdf-download/51229",previewPdfUrl:"/chapter/pdf-preview/51229",authors:[{id:"183920",title:"Ph.D.",name:"Clinton",surname:"Jones",slug:"clinton-jones",fullName:"Clinton Jones"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"825",title:"Current Topics in Tropical Medicine",subtitle:null,isOpenForSubmission:!1,hash:"ef65e8eb7a2ada65f2bc939aa73009e3",slug:"current-topics-in-tropical-medicine",bookSignature:"Alfonso J. 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Abd El-Baky",authors:[{id:"103658",title:"Dr.",name:"Rehab Mahmoud",middleName:null,surname:"Abd El-Baky",fullName:"Rehab Mahmoud Abd El-Baky",slug:"rehab-mahmoud-abd-el-baky"}]},{id:"30956",title:"Interrelated Analysis of Performance and Fouling Behaviors in Forward Osmosis by Ex-Situ Membrane Characterizations",slug:"interrelated-analysis-of-performance-and-fouling-behaviors-in-forward-osmosis-by-ex-situ-membrane-ch",signatures:"Coskun Aydiner, Semra Topcu, Caner Tortop, Ferihan Kuvvet, Didem Ekinci, Nadir Dizge and Bulent Keskinler",authors:[{id:"109299",title:"Associate Prof.",name:"Coskun",middleName:null,surname:"Aydiner",fullName:"Coskun Aydiner",slug:"coskun-aydiner"}]},{id:"30957",title:"Biodegradation of Pre-Aged Modified Polyethylene Films",slug:"biodegradation-of-pre-aged-modified-polyethylene-films",signatures:"Bożena Nowak, Jolanta Pająk and Jagna Karcz",authors:[{id:"103087",title:"Dr.",name:"Bożena",middleName:"Danuta",surname:"Nowak",fullName:"Bożena Nowak",slug:"bozena-nowak"},{id:"108409",title:"Dr.",name:"Jolanta",middleName:null,surname:"Pająk",fullName:"Jolanta Pająk",slug:"jolanta-pajak"},{id:"108412",title:"Dr.",name:"Jagna",middleName:null,surname:"Karcz",fullName:"Jagna Karcz",slug:"jagna-karcz"}]},{id:"30958",title:"Surface Analysis Studies on Polymer Electrolyte Membranes Using Scanning Electron Microscope and Atomic Force Microscope",slug:"surface-analysis-studies-on-polymer-electrolyte-membranes-using-scanning-electron-microscope-and-ato",signatures:"M. Ulaganathan, R. Nithya and S. Rajendran",authors:[{id:"102326",title:"Dr.",name:"M",middleName:null,surname:"Ulaganathan",fullName:"M Ulaganathan",slug:"m-ulaganathan"},{id:"102329",title:"Prof.",name:"S",middleName:null,surname:"Rajendran",fullName:"S Rajendran",slug:"s-rajendran"}]},{id:"30959",title:"Characterization of Ceramic Materials Synthesized by Mechanosynthesis for Energy Applications",slug:"characterization-of-ceramic-materials-synthesized-by-mechanosynthesis-for-energy-applications",signatures:"Claudia A. Cortés-Escobedo, Félix Sánchez-De Jesús, Gabriel Torres-Villaseñor, Juan Muñoz-Saldaña and Ana M. Bolarín-Miró",authors:[{id:"39070",title:"Dr.",name:"Ana Maria",middleName:null,surname:"Bolarin-Miro",fullName:"Ana Maria Bolarin-Miro",slug:"ana-maria-bolarin-miro"},{id:"106669",title:"Dr.",name:"Claudia Alicia",middleName:null,surname:"Cortés-Escobedo",fullName:"Claudia Alicia Cortés-Escobedo",slug:"claudia-alicia-cortes-escobedo"},{id:"107412",title:"Dr.",name:"Juan",middleName:null,surname:"Munoz-Saldana",fullName:"Juan Munoz-Saldana",slug:"juan-munoz-saldana"},{id:"107419",title:"Dr.",name:"Felix",middleName:null,surname:"Sanchez-De Jesus",fullName:"Felix Sanchez-De Jesus",slug:"felix-sanchez-de-jesus"},{id:"124602",title:"Prof.",name:"Gabriel",middleName:null,surname:"Torres-Villasenor",fullName:"Gabriel Torres-Villasenor",slug:"gabriel-torres-villasenor"}]},{id:"30960",title:"Scanning Electron Microscopy (SEM) and Environmental SEM: Suitable Tools for Study of Adhesion Stage and Biofilm Formation",slug:"scanning-electron-microscopy-sem-and-environnmental-sem-suitable-tools-for-study-of-adhesion-stage-a",signatures:"Soumya El Abed, Saad Koraichi Ibnsouda, Hassan Latrache and Fatima Hamadi",authors:[{id:"102518",title:"Dr.",name:"Soumya",middleName:null,surname:"El Abed",fullName:"Soumya El Abed",slug:"soumya-el-abed"},{id:"135701",title:"Prof.",name:"Saad",middleName:null,surname:"Koraichi Ibnsouda",fullName:"Saad Koraichi Ibnsouda",slug:"saad-koraichi-ibnsouda"},{id:"135703",title:"Prof.",name:"Latrache",middleName:null,surname:"Hassan",fullName:"Latrache Hassan",slug:"latrache-hassan"},{id:"135704",title:"Prof.",name:"Hamadi",middleName:null,surname:"Fatima",fullName:"Hamadi Fatima",slug:"hamadi-fatima"}]},{id:"30961",title:"Scanning Electron Microscopy Study of Fiber Reinforced Polymeric Nanocomposites",slug:"scanning-electron-microscopy-study-of-fiber-reinforced-polymeric-nanocomposites",signatures:"Mohammad Kamal Hossain",authors:[{id:"104713",title:"Dr.",name:"Mohammad",middleName:null,surname:"Hossain",fullName:"Mohammad Hossain",slug:"mohammad-hossain"}]},{id:"30962",title:"Preparation and Characterization of Dielectric Thin Films by RF Magnetron-Sputtering with (Ba0.3Sr0.7)(Zn1/3Nb2/3)O3 Ceramic Target",slug:"preparation-and-characterization-of-dielectric-thin-films-by-rf-magnetron-sputtering-with-ba0-3sr0-7",signatures:"Feng Shi",authors:[{id:"24821",title:"Dr.",name:"Feng",middleName:null,surname:"Shi",fullName:"Feng Shi",slug:"feng-shi"}]},{id:"30963",title:"Microstructural and Mineralogical Characterization of Clay Stabilized Using Calcium-Based Stabilizers",slug:"microstructural-and-mineralogical-characterization-of-clay-stabilized-using-calcium-based-stabilizer",signatures:"Pranshoo Solanki and Musharraf Zaman",authors:[{id:"20942",title:"Prof.",name:"Pranshoo",middleName:null,surname:"Solanki",fullName:"Pranshoo Solanki",slug:"pranshoo-solanki"},{id:"20945",title:"Prof.",name:"Musharraf",middleName:null,surname:"Zaman",fullName:"Musharraf Zaman",slug:"musharraf-zaman"}]},{id:"30964",title:"The Use of ESEM in Geobiology",slug:"the-use-of-esem-in-geobiology",signatures:"Magnus Ivarsson and Sara Holmström",authors:[{id:"109413",title:"Dr.",name:"Magnus",middleName:null,surname:"Ivarsson",fullName:"Magnus Ivarsson",slug:"magnus-ivarsson"},{id:"135734",title:"Dr.",name:"Sara",middleName:null,surname:"Holmström",fullName:"Sara Holmström",slug:"sara-holmstrom"}]},{id:"30965",title:"How Log Interpreter Uses SEM Data for Clay Volume Calculation",slug:"how-log-interpreter-uses-sem-data-to-estimate-a-reservoir-clay-volume-",signatures:"Mohammadhossein Mohammadlou and Mai Britt Mørk",authors:[{id:"103154",title:"PhD.",name:"Mohammadhossein",middleName:null,surname:"Mohammadlou",fullName:"Mohammadhossein Mohammadlou",slug:"mohammadhossein-mohammadlou"}]}]}],publishedBooks:[{type:"book",id:"356",title:"Laser Pulse Phenomena and Applications",subtitle:null,isOpenForSubmission:!1,hash:"0326c656c0dd5480c2dd15d22a772d18",slug:"laser-pulse-phenomena-and-applications",bookSignature:"F. 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Flutter is one of the most dangerous aeroelasticity phenomena as it could lead to a destroyed structure. The reason is the unsteady aerodynamic forces generated from elastic deformations of the structure that are usually involved with complicated phenomena such as the shock wave/boundary layer interaction, flow separation, nonlinear limited cycle oscillation, and more. Flutter is determined as a critical issue determining the reliability of the airplane wings or aircraft engine turbo-machine blades. Therefore, in the early phase of the structural design of the air vehicle, aircraft engine turbo-machinery, flutter problems should be calculate and predicted. However, accurate prediction of the flutter is very challenging due to the perplexing physical phenomena and the required large amount of computation [1, 2, 3, 4].
Coupled aeroelastic solution procedures use strongly coupled algorithms which contained sufficient interaction between computational fluid dynamics (CFD) and computational structural dynamics (CSD). As computer technology progresses, higher-order methods of CFD based on the Euler and the Navier-Stokes equations become more attractive due to the ability of the model and its more accurately transonic, nonlinear, and viscous effects. CFD has also advanced from two-dimensional problems to fully three-dimensional problems with or without coupled solution of the structural equations (CSD). The flow solvers used in aeroelastic analysis include 3D Euler and Navier-Stokes solvers which assumed inviscid flow.
The dynamic response of flutter characteristics of the first AGARD 445.6 wing standard aeroelastic configuration was studied using an unsteady Navier-Stokes algorithm in order to investigate a previously noted discrepancy between Euler flutter characteristics and the experimental data [5]. The 3D implicit upwind Euler/Navier-Stokes code (CFL3D Version 2.1) was previously modified for the time-marching aeroelastic analysis of wings using the unsteady Euler equations. A linear stability analysis and a time-marching aeroelastic analysis were used to determine the flutter characteristics of the isolated 45° swept-back wing. The flutter characteristics of the wing were determined using traditional V-g analysis. This stability analysis was determined at free-stream Mach numbers of 0.96 and 1.141 using the generalized aerodynamic forces calculated by solving the Euler equations and the Navier-Stokes equations.
Computational flutter required a fluid-structure interface as a common boundary to exchange the aerodynamic loads and structural displacements at the wing surface. But, the aerodynamic and structural grids were not coincident due to different systems used (fluent solver for aerodynamic grids and mechanical ADPL solver for structural grids). Therefore, the system coupling tool in ANSYS Workbench was used to transfer the aerodynamic pressure loads from the CFD grid points to the CSD grid points and vice versa, which ensured a conservative transfer of energy between the two systems [6].
Time-accurate aeroelastic simulations were carried out using the modal coupled aeroelastic implementation for a standard experimental test case: the AGARD 445.6 aeroelastic wind tunnel model in the subsonic and transonic regions [7]. A numerical methodology coupling Navier-Stokes equations and structural modal equations for predicting 3D transonic wing flutter was described in [8]. A modal approach is used for the structural response. The results indicate that the first five modes are sufficient to accurately model the wing structure response. In Ref. [9], an unsteady Reynolds-averaged Navier-Stokes (RANS) model was coupled with normal modes of structure to predict the flutter boundary for the AGARD 445.6 wing. A new integrated CFD-CSD simulation for flutter calculations based on a parallel, multiblock, multigrid flow solver for the Euler/Navier-Stokes equations using the ANSYS software was found in [10]. Computations were performed for a three-dimensional test case of AGARD 445.6 wing to validate and establish the usefulness of the simulation. Immersed boundary method solved Navier-Stokes equations for flow in couple with the Newton equation for structure movement under the effect of friction force exerted on the structure surface to carry out fluid–structure interaction (FSI). However, computational grids needed to be re-meshed in each time step due to changes of the structure position in time. To overcome this obstacle, immersed boundary method and finite volume methods were both invoked in solving the interaction between fluid flow and moving structure [11]. This research estimated the numerical and experimental results on the wing structure at a low speed with four different wing models such as two rectangular and two trapezoid 3D-shape wings, each 3D-shape wing had symmetric and asymmetric airfoil, respectively.
The subsonic aeroelastic stability of a two-dimensional panel resting on a continuous elastic foundation was investigated in Ref. [12]. Tests were conducted experimentally on a 104 × 24 × 0.018 in. rectangular aluminum panel in a low-speed wind tunnel. Comparison of experiment and theory showed a good agreement in flutter speed and wavelength but poor agreement in wave speed and frequency at flutter. This discrepancy was attributed to the limitations in the test setup as well as to the general difficulty of predicting the wave speed and frequency as accurately as the flutter speed. Reference [13] tested the first AGARD standard aeroelastic configuration for dynamic response, 445.6 wing, in the 16 foot transonic dynamics tunnel at the National Aeronautics and Space Administration (NASA) Langley Research Center. Several models of the wing were tested in the transonic dynamic tunnel including full-span and semispan models over a range of Mach number from 0.338 to 1.141. The NASA conducted experiments in wind tunnel to estimate the aeroelastic characteristics of new and advanced flight vehicles, including fixed-wing, rotary-wing, and space-launch configurations. Reviews and assessments were made regarding available facilities, measurement techniques, and other means and devices useful in testing. The needs and requirements for advances and improvements in testing capabilities for future experimental research and development programs are described [14].
In [15], aeroelastic concepts for increased aircraft performance were mentioned. Active aeroelastic concepts as well as robust analysis concepts aiming at efficient analysis were carried out using numerical models with uncertain or varying model parameters. A high aspect ratio wing in wind tunnel testing conditions was considered for exploitation of fluid-structure interaction of active aeroelastic structures. The structural flexibility was exploited by using multiple control surfaces such that the deformed wing shape gives minimum drag for different flight conditions. Two different drag minimization methods were carried out: one was to reduce induced drag based on numerical optimization techniques, and another was to reduce measured total drag using real-time optimization in the wind tunnel experiment.
An approach for the prediction of dynamic modal transient response and flutter characteristics of structures with unknown system parameters, such as stiffness and mass, using experimental modal parameters was remarked in [16]. A finite element model was created by using the actual material properties of the structure to study the correlation of the results. The computed transient responses and flutter velocities by the proposed method using experimental modal parameters observed that material properties were not a prerequisite.
In Ref. [17], transonic flutter characteristics of AGARD 445.6 wing between the numerical method [5] and the experimental data of NASA’s experiment were compared [13]. The comparison provided the basis for developing the numerical setup and the experimental setup to check out subsonic flutter characteristics of some simple wing structures (e.g., a thin plate). Aeroelasticity on airplane wing, which had supercritical airfoil, was carried out in [18]. The model wings were made from different materials and dimensions. Hence, varied wing structures were created to accomplish a comprehensive analysis, and the flutter velocity was also restricted to appropriate values within the working range of experiment devices. At the same time, infinite element method with the help of the ANSYS software was also conducted to simulate the phenomena on the same model wings as a verification for the precision of the experimental models.
The generalized equations of aeroelasticity motion:
where:
w: structural displacement at any time instant and position.
q: generalized displacement vector.
[M]: generalized mass matrice.
[C]: damping matrice.
[K]: stiffness matrices.
ϕ: normal modes of the structure.
N: total number of modes of the structure.
F: generalized force vector, which is responsible for linking the unsteady aerodynamics and inertial loads with the structural dynamics.
Eq. (1) shows that there are distinct terms representing the structure, aerodynamic, and dynamic disciplines. This equation was solved numerically by integrated CFD-CSD tool on the ANSYS software. This method was also called the two-way fluid-solid interaction (FSI). Aerodynamic loads were first calculated by CFD solver. Then, these loads were used to calculate the structural response of the wing structure through the fluid-solid interface. By using CSD solver, the structural deflection was estimated, and the mesh in each time step was deformed. The simulation of the two-way FSI is presented in Figure 1 [10].
Two-way FSI algorithm.
Following [8], the first four modes of vibration were sufficient to accurately model the wing structure response. So, in order to determine the time step of the unsteady problem, a modal method was applied to estimate first the natural frequency of the first four modes and then calculate the time step using the following formula:
where:
Δt: time step
f: natural frequency
The flutter velocity was estimated from the vibration of the wing tip position, the most dangerous position of the wing [5, 8, 9, 13]. From the variation of this position, the damping coefficient except the influence of structural damping was measured. It means that there was an effect of aerodynamic damping coefficient on the vibration of the wing structure. The aerodynamic damping coefficient was calculated as follows:
where:
Xi: ith peak of vibration.
n: number of periods.
ζ: aerodynamic damping coefficient.
The damping coefficient increased/decreased when the air velocity decreased/increased. The type of vibration was distinguished from the value of damping coefficient:
ζ > 0: The vibration was convergent. The wing structure was stable.
ζ < 0: The vibration was divergent. The wing structure was unstable.
ζ = 0: The vibration was harmonic oscillation. The wing was in critical state. The air velocity was in the flutter velocity.
AGARD 445.6 wing with aspect ratio of 1.65, taper ratio of 0.66, and 45o sweep angle at quarter chord line was studied as seen in Figure 2. The cross section of the wing was NACA65A004 airfoil in the stream-wise direction. This NACA65A004 airfoil was a symmetric airfoil with a maximum thickness of 4% of the local chord. The dimensions of the wing were root chord of 0.558 m, tip chord of 0.368 m, and semispan of 0.762 m. The wing model used in aeroelastic experiments [13] was constructed by laminated mahogany which was modeled as an orthotropic material with different material properties in different directions. The properties of the laminated mahogany are given in Table 1. The modal analysis was performed using mechanical APDLs solver to evaluate the accuracy of the constructed model.
Semispan AGARD 445.6 wing model.
Material property | E11 | E22 | E33 | G | υ | ρ |
---|---|---|---|---|---|---|
Value | 3.151 | 0.416 | 0.416 | 0.439 | 0.310 | 397.5 |
Unit | GPa | GPa | GPa | GPa | N/m2 | kg/m3 |
Mechanical properties for the weakened AGARD 445.6 wing.
The AGARD 445.6 wing was modeled at a zero attack angle and at altitudes of 9.65 and 14 km, the same conditions of experimental study in [13]. The wing was meshed in 9257 nodes and 1350 elements (Figure 3a). The fluid domain in CFD problem was meshed in 67,949 nodes and 279,535 elements (Figure 3b).
Computational grids. (a) AGARD 445.6 wing grids. (b) Fluid computational grids.
The free-stream air velocity was from 0.29 to 0.59 M at an altitude of 9.65 km and from 0.47 M to 0.73 M at an altitude of 14 km.
The mode shapes are obtained from the finite element analysis of the modeled wing. The deflection contours between the modal analysis and experiment [13] were compared as shown in Figure 4. The natural frequencies between the developed solution, experiment [13], and other researches were also compared as shown in Table 2. It could be concluded that the obtained results were in good agreement with the experimental results in [4, 6, 13] within an error relative of 8%. The frequency of the first mode was around 9.96 Hz. Following Eq. (3), the time step of the unsteady problem was estimated about 0.005 s.
Comparison of the mode shapes. (a) Mode 1. (b) Mode 2. (c) Mode 3. (d) Mode 4.
At altitude 9.65 km, the Mach number of air velocity was varied from 0.29 to 0.59 (M = 0.29; 0.35; 0.41; 0.47; 0.53; 0.59). From Eq. (4), the aerodynamic damping coefficient was calculated and presented in Figure 5a. The zero damping coefficients were interpolated at Mach number 0.46. While the experimental zero damping was 0.499 in [13], the difference between simulation results and results of [13] was about 8%.
Aerodynamic damping coefficients. (a) At altitude 9.65 km. (b) At altitude 14 km.
At altitude 14 km, the Mach numbers of air velocity were varied from 0.47 to 0.73 (M = 0.47; 0.53; 0.59; 0.65; 0.67; 0.73). From Eq. (4), the aerodynamic damping coefficient was calculated and presented in Figure 5b. The zero damping coefficients were interpolated at Mach number 0.58. While the experimental zero damping was 0.678 in [13], the difference within simulation results was about 14%.
In both the two considered altitudes (9.65 and 14 km), the numerical results agreed well with the experimental results of [13] with a relative error about 14%. This difference would be from the computation such as the quality of mesh and order of model in CFD and CSD.
For more details of the stability of the wing structure, the vibrated value of the wing tip position at three Mach numbers were plotted as shown in Figure 5.
At a Mach number smaller than the flutter value, the damping coefficient was positive, and the wing was stable (Figure 6a).
Vibration of wing at altitude H = 9.65 km. (a) M = 0.29 – ζ = 0.0071. (b) M = 0.47 – ζ = −0.000125. (c) M = 0.53 – ζ = −0.006.
At a Mach number near the flutter value, the damping coefficient was zero, and the vibration was harmonic oscillation (Figure 6b).
At a Mach number greater than the flutter value, the damping coefficient was negative, and the vibration was divergent (Figure 6c). This divergent vibration would create the damage of the wing such as loss of control for the flap, aileron, fracture of wing, etc.
Dynamic aeroelastic analysis was a problem related to fluid-structure interaction over a period of time. Therefore, the quality of aerodynamic grid and the time step strongly influenced the results of aeroelastic analysis. These parameters were also two of the most important problems in the dynamic aeroelastic analysis.
In order to evaluate the quality of aerodynamic grid, the coefficient of pressure of AGARD 445.6 wing was first estimated at 26% semispan and at 75.5% semispan and then was compared with Ref. [6] as shown in Figure 7. The presented results were in good agreement with the results in Ref. [6]. It could be concluded that these simulation settings were appropriate for solving the transonic flow.
Comparison of Cp distribution at M = 1.141, α = 0°. (a) 26 % semispan. (b) 75.5 % semispan.
To evaluate the time step size, three different time sizes were examined such as 0.001, 0.002, and 0.005 s. As it could be seen in Figure 8, the displacement of the wing tip was reduced with the reduction of time step size up to 0.002 s until the aeroelastic simulation did not change [6]. Therefore, the value 0.002 s of time step size in the numerical solution was chosen for both aerodynamic and structural analysis.
Wing-tip oscillation depends on the selected time step.
The limit of flutter was identified by using damping estimations for a large test point at each Mach number. At M = 0.499, the oscillation of the displacement of the wing tip was harmonic (Figure 9), and it was considered as a flutter point. At this limit of flutter, the air speed was calculated as 174.26 m/s, and the density of air was calculated as 0.432 kg/m3. These values were very close to the experimental values: 172.46 m/s for flutter speed and 0.428 kg/m3 for density of air (Table 3). This remark illustrated that the developed solution could be used to specify the transonic flutter characteristics with errors less than 10%.
Wing-tip oscillation of flutter point at M = 0.499.
The test model was set in AF6116 (M = 0.1) subsonic wind tunnel located at the Hanoi University of Science and Technology, which was of a blowdown type with a closed test section (0.4 × 0.5 × 1.0 m3). The wind speed could be arbitrarily varied up to 30 m/s, where the Reynolds number based on wing root chord was 106, which was driven by an 8 kW electric motor.
Flutter characteristics were determined with the help of the frequency meter and load cell, which allowed to specify the flutter frequency and root wing force, respectively. The oscillated frequency was measured by the DT-2234C+ frequency meter. The signal of measured frequency was averaged by five measurements. The force applied to the wing was measured by load cell system. In the experimental aeroelastic analysis, the flutter frequency and the flutter amplitude were measured at different velocities ranging from 10 to 30 m/s using an oscillator generator system.
Two wing models with the parameter and dimension are shown in Figure 10 and Table 4. The non-structure wing had only balsa wood, while the structure wing had balsa wood for skin and carbon rod and hard wood for the inner parts.
Experimental models. (a) Wing model. (b) Wing with support. (c). Broken wing.
Wing 1 (non-structure) | Wing 2 (with structure) | |
---|---|---|
Chord length | 300 mm | 300 mm |
Root chord length | 500 mm | 500 mm |
Tip chord length | 100 mm | 100 mm |
Profile | NACA65A004 | NACA65A004 |
Taper ratio | 0.5 | 0.5 |
Material | Balsa wood | Balsa wood, carbon rod, hard wood |
Mass | 5.1 g | 11.6 g |
Wing models.
Experimental results showed that a flutter phenomenon appeared with the non-structure wing (broken wing in Figure 10c), but this phenomenon did not happen with the structure wing model. It could be explained by the more durability of structure wing than that of the non-structure wing with the testing range of velocity. Experiments also demonstrated that the combination of multiple materials to more durability of structure of wing could be highly effective in preventing flutter phenomenon [18].
The measurement results of the non-structure wing were shown in Table 5. When the attack angle increased, the velocity of first oscillation, flutter velocity, and frequency decreased.
Attack angle (0) | Velocity of first oscillation (m/s) | Flutter velocity (m/s) | Frequency (Hz) |
---|---|---|---|
0 | 20 | 22 | 37.38 |
5 | 17.8 | 20.5 | 32.22 |
10 | 15.2 | 19.5 | 30.31 |
Flutter characteristics at different attack angles—Non-structure wing.
Figure 11 resumed the measurement of the force at the wing root in varying velocities from zero to flutter velocity and more by using the load cell system. After increasing the air velocity from zero to the limit of non-structure wing, the limit velocity of non-structure wing was found at 19.5 m/s. The load at the wing root of this wing at flutter velocity is shown in Figure 12. The maximum force was 5.44 N, and the minimum force was 4.32 N.
Force at the wing root of the non-structure wing—Attack angle 10°.
Force at the wing root of the non-structure wing—Attack angle 10° and velocity 19.5 m/s.
With structure wing, different modes of vibration appeared depending on the characteristics of the structure as remarked in [8]. With the help of the oscillator generator system, the specific oscillation frequencies of the first four modes were estimated as shown in Table 6.
Mode | Frequency (Hz) | |
---|---|---|
Non-structure wing | Structure wing | |
1 | 24.3 | 23.5 |
2 | 67.0 | 63.0 |
3 | 103.6 | 115.3 |
4 | 132.0 | 139.0 |
Specific oscillation frequency of the non-structure and structure wings.
The frequencies of the first and second modes of the non-structure wing were higher than those of the structure wing, while the frequencies of third and fourth mode of structure wing were higher than those of non-structure wing (Table 6). Considering both wings in the first mode of oscillation, when the force was applied to the wing, the amplitude of the non-structure wing was higher than that of the structure wing (Figure 13). In conclusion, the non-structure wing was easier to resonate than the structure wing.
Amplitude of oscillation of the structure wing—Mode 1.
Fluid flow and deformation of structure were governed by the following equations with assumption of linear elastic structure [11]:
where:
u: fluid velocity vector
p: fluid pressure
f: force that affected on wing
Re: Reynolds number
Uc: displacement velocity
ωp: angular velocity
xc: center of gravity
θp: rotation of wing r
mp: mass of wing
Ip: inertial moment of wing
F: force created by fluid passing through the wing
T: moment created by fluid passing through the wing
To solve out these equations using IBM method, the most important was that the velocity of fluid at fluid-solid interface was equal to the velocity of the wing. It means that the interaction force (f) between the wing and fluid was calculated such that the boundary condition of fluid was satisfied on the surface of the wing.
IBM method used the Cartesian grid and immersed boundary that were illustrated in Figure 14, in which the moving surface of wing was described by Lagrangian points (rounded points) and fixed points in fluid were called Eulerian points. Parameters of Lagrangian points were noted as capitalization.
Cartesian grid and immersed boundary.
Discrete partial derivative of velocity over time in Eq. (5) with denote intermediate velocity at zero force of Lagrangian point, Ûk, force F of Lagrangian points were estimated as follows:
where:
k: time step.
Uk+1: identified from the moving surface of wing, so this velocity was known as U(b).
Force was created from displacement and affected on the fluid element. Force was calculated using the following interpolation formula:
where:
x: coordinate of Eulerian point.
N: set of Lagrangian points round Eulerian point
x
∆U
δh: 3D delta function identified as follows:
Three-step Runge–Kutta method was applied to solve Navier-Stokes equations and Newton equations as follows:
Step 1: Calculate the instantaneous velocity at Eulerian points with no immersed boundary surface, i.e., f = 0:
where:
k: step calculation of Runge-Kutta method (k = 1, 2, 3)
αk: coefficient of kth step calculation
γk: coefficient of kth step calculation
ζk: coefficient of kth step calculation
υ: kinematic viscosity
Apply this instantaneous velocity to calculate Lagrangian velocity on the surface of the wing:
This Lagrangian velocity was combined with wing velocity, U(b)x
Step 2: Solve out Navier-Stokes Eqs. (5) using calculated forces of Eulerian points to estimate the effect of flutter of the wing into the velocity field around the wing:
To satisfy the continuity equation, a temporary pressure was described:
Step 3: Solve Eq. (17), and calculate velocity and pressure at kth step of the Runge-Kutta method:
From the estimated forces at Lagrangian points, translational and angular movements of the wing were carried out by solving Eqs. (7) and (9):
After calculating the velocity of center of gravity (Uck) and angular velocity of wing (ωpk), coordinates of Lagrangian points were estimated by the same expressions.
Four different wing models were carried out in order to analyze the effect of the wing structure. There were two rectangular and two trapezoid 3D-shape wings, and each 3D-shape wing had symmetric (NACA65A004) and asymmetric (supercritical) airfoil, respectively. The wings had the same area of 450 cm2 and the same semispan-wise length of 30 cm. Therefore, the rectangular wing had a chord length of 7.5 cm, while the trapezoidal wing has no sweep angle, and the leading edge line had a tip chord length of 5 cm and root chord length of 10 cm. The wings were made of aluminum (Figure 15).
Wing models. (a) Rectangular wing. (b) Trapezoidal wing.
Experiments were performed using a low-speed blowdown wind tunnel, which belongs to the Department of Aerospace Engineering at the Hanoi University of Science and Technology, Vietnam. This wind tunnel had a maximum free-stream velocity in empty test section of 30 m/s that corresponded to Reynolds number 106. The wind tunnel was operated continuously by an 8 kW electric motor. The turbulence level in test section was slightly less than 1%. Free-stream velocity was kept constant in test section within ±2%. Total pressure of free-stream and dynamic pressures were measured by pitot tube within ±2%. Ambient temperature was measured within ±1%. Both experimental and numerical researches were performed at air velocity of 20 m/s and attack angle of 5°.
For the experimental study, 160 pressure taps were applied on the wing model (Figure 15). These pressure taps were connected to an external digital manometer via stainless and silicon tubes. Each pressure tap was measured one time with waiting time of 5 s (average of about 1000 instant values) using the Keyence pressure measurement. The standard deviation of the Keyence pressure measurement errors was within ±0.001 Pa. Moreover, flutter of wing was captured with help of high performance camera.
The results of IBM method were analyzed at three different instants (Figure 16):
Time T0: initial time when distortion did not occurred
Time T1: time between maximum deformation and non-deformation
Time T2: time of maximum distortion
Instant displacement of wings. (a) NACA65A004 – Rectangular wing. (b) NACA65A004 – Trapezoidal wing. (c) Supercritical – Rectangular wing. (d) Supercritical – Trapezoidal wing.
The wing deformation was maximum at the tip of the wing and decreased gradually into the root of the wing over time. However, the normal stress was found to have an opposite tendency in comparison with deformation. The maximum normal stress was observed at the root of the wing, while the minimum normal stress was found at the tip of the wing (Figures 17 and 18). It could be explained by the fixed support with fuselage at the root of the wing and free support at the tip of the wing [13]. These remarks were in well agreement with the experimental results within a relative error less than 10% (Table 7).
Instant normal stress—Rectangular wing.
Instant normal stress—Trapezoidal wing.
Wing | IBM method (mm) | Experiment method (mm) | Relative error (%) |
---|---|---|---|
NACA65A004-rectangular | 0.119 | 0.131 | 9.7 |
NACA65A004-trapezoidal | 0.030 | 0.033 | 8.6 |
Supercritical-rectangular | 0.035 | 0.039 | 9.9 |
Supercritical-trapezoidal | 0.034 | 0.037 | 9.2 |
Maximum deformation of the wing tip.
At T0 instant, the normal stress had important value near the wing tip. During flutter behaviors of wing, this important normal stress propagated from the tip of the wing to the root of the wing. The maximum value of the normal stress was found out at the root of the wing and at T2 instant.
With the same airfoil, the rectangular wing was found to be more distorted and have higher maximum deformation and higher maximum normal stress than the trapezoid wing. Thus, 3D-shape wing contributed significantly to the deformation of wing when aeroelasticity phenomenon occurred (Table 7).
With the same 3D-shape wing, the maximum deformation and maximum normal stress of NACA65A004 rectangular wing were higher than those of the rectangle supercritical wing. Meanwhile, the maximum deformation and maximum normal stress of NACA65A004 trapezoidal wing were less than those of the supercritical trapezoidal wing. It could be concluded that the 3D shape of wing played an important role in the durability of the structure (Table 7).
The flutter phenomenon of AGARD 445.6 wing was determined by (a) a modal approach for a structural response; (b) an aerodynamic damping coefficient to predict the appearance of flutter phenomenon; (c) a strongly coupled FSI method to predict the aeroelastic response for subsonic and transonic flutter characteristics; (d) an experiment method to predict the aeroelastic response for subsonic flutter characteristics with wing structure; (e) and an IBM method to improve the interface between the fluid and solid of aircraft wing.
In brief, the major results could be summarized as follows:
Experimental results were in good agreement with numerical results within a relative error less than 10%.
During aeroelasticity phenomenon, deformation of the wing tip was maximum while it was minimum at the wing root. The tendency of normal stress was in contrast with deformation. The minimum normal stress was observed at the wing tip, while the maximum normal stress was observed at the wing root;
Geometry of wing (3D shape, airfoil) had a significantly contribution to the deformation of wing when aeroelasticity phenomenon occurred.
For further research of aeroelasticity in the future, both experimental and numerical researches at low and high speed should be performed.
A part of this work was supported by the Ministry of Science and Technology in Vietnam through the bilateral and multilateral research project HNQT/SPĐP/12.19.
structural displacement at any time instant and position
generalized displacement vector
generalized mass matrice
damping matrice
stiffness matrices
normal modes of the structure
total number of modes of the structure
generalized force vector
ith peak of vibration
number of period
aerodynamic damping coefficient
Mach number
fluid velocity vector
fluid pressure
force that affected on wing
Reynolds number
displacement velocity
angular velocity
center of gravity
rotation of wing
mass of wing
inertial moment of wing
force that created by fluid go pass through the wing
moment that created by fluid go pass through the wing
coordinate of Eulerian point
set of Lagrangian points round Eulerian point
coordinate of Lagrangian point
volume of effect corresponded to Lagrangian point
3D delta function
coefficient of step Runge-Kutta calculation
kinematic viscosity
normal stress following x-coordinates
normal stress following y-coordinates
normal stress following z-coordinates
shear stress
density
coefficient of pressure
attack angle
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