\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 179 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 252 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\n'}],latestNews:[{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"}]},book:{item:{type:"book",id:"3116",leadTitle:null,fullTitle:"Advances in Industrial Design Engineering",title:"Advances in Industrial Design Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:'A fast paced changing world requires dynamic methods and robust theories to enable designers to deal with the new product development landscape successfully and make a difference in an increasingly interconnected world. Designers continue stretching the boundaries of their discipline, and trail new paths in interdisciplinary domains, constantly moving the frontiers of their practice farther. \nThis book, the successor to "Industrial Design - New Frontiers" (2011), develops the concepts present in the previous book further, as well as reaching new areas of theory and practice in industrial design. "Advances in Industrial Design Engineering" assists readers in leaping forward in their own practice and in preparing new design research that is relevant and aligned with the current challenges of this fascinating field.',isbn:null,printIsbn:"978-953-51-1016-3",pdfIsbn:"978-953-51-6319-0",doi:"10.5772/3415",price:119,priceEur:129,priceUsd:155,slug:"advances-in-industrial-design-engineering",numberOfPages:252,isOpenForSubmission:!1,isInWos:1,hash:"9cb2d954a2f9ea36c3d0f915a7fcd8ad",bookSignature:"Denis A. 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Whizar-Lugo and Dr. José Ramón Saucillo-Osuna",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10708.jpg",keywords:"Regional Anesthesia, Ultrasound-Guided Regional Anesthesia, Local Anesthetics, Preventive Analgesia, Peripheral Blocks, Pediatric Regional Anesthesia, Intravenous Regional Anesthesia, Techniques, Complications, Adjuvants in Regional Anesthesia, Opioids, Alfa2 Agonists",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 23rd 2021",dateEndSecondStepPublish:"March 23rd 2021",dateEndThirdStepPublish:"May 22nd 2021",dateEndFourthStepPublish:"August 10th 2021",dateEndFifthStepPublish:"October 9th 2021",remainingDaysToSecondStep:"18 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Whizar-Lugo has published more than 100 publications on Anesthesia, Pain, Critical Care, and Internal Medicine. He works as an anesthesiologist at Lotus Med Group and belongs to the Institutos Nacionales de Salud as an associated researcher.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"169249",title:"Prof.",name:"Víctor M.",middleName:null,surname:"Whizar-Lugo",slug:"victor-m.-whizar-lugo",fullName:"Víctor M. Whizar-Lugo",profilePictureURL:"https://mts.intechopen.com/storage/users/169249/images/system/169249.jpg",biography:"Víctor M. Whizar-Lugo graduated from Universidad Nacional Autónoma de México and completed residencies in Internal Medicine at Hospital General de México and Anaesthesiology and Critical Care Medicine at Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in México City. He also completed a fellowship at the Anesthesia Department, Pain Clinic at University of California, Los Angeles, USA. Currently, Dr. Whizar-Lugo works as anesthesiologist at Lotus Med Group, and belongs to the Institutos Nacionales de Salud as associated researcher. He has published many works on anesthesia, pain, internal medicine, and critical care, edited four books, and given countless conferences in congresses and meetings around the world. He has been a member of various editorial committees for anesthesiology journals, is past chief editor of the journal Anestesia en México, and is currently editor-in-chief of the Journal of Anesthesia and Critical Care. Dr. Whizar-Lugo is the founding director and current president of Anestesiología y Medicina del Dolor (www.anestesiologia-dolor.org), a free online medical education program.",institutionString:"Institutos Nacionales de Salud",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],coeditorOne:{id:"345887",title:"Dr.",name:"José Ramón",middleName:null,surname:"Saucillo-Osuna",slug:"jose-ramon-saucillo-osuna",fullName:"José Ramón Saucillo-Osuna",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000033rFXmQAM/Profile_Picture_1611740683590",biography:"Graduated from the Facultad de Medicina de la Universidad Autónoma de Guadalajara, he specialized in anesthesiology at the Centro Médico Nacional de Occidente in Guadalajara, México. He is one of the most important pioneers in Mexico in ultrasound-guided regional anesthesia. Dr. Saucillo-Osuna has lectured at multiple national and international congresses and is an adjunct professor at the Federación Mexicana de Colegios de Anestesiología, AC, former president of the Asociación Mexicana de Anestesia Regional, and active member of the Asociación Latinoamericana de Anestesia Regional.",institutionString:"Centro Médico Nacional de Occidente",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"347258",firstName:"Marica",lastName:"Novakovic",middleName:null,title:"Dr.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"marica@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"878",title:"Phytochemicals",subtitle:"A Global Perspective of Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"ec77671f63975ef2d16192897deb6835",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/878.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4816",title:"Face Recognition",subtitle:null,isOpenForSubmission:!1,hash:"146063b5359146b7718ea86bad47c8eb",slug:"face_recognition",bookSignature:"Kresimir Delac and Mislav Grgic",coverURL:"https://cdn.intechopen.com/books/images_new/4816.jpg",editedByType:"Edited by",editors:[{id:"528",title:"Dr.",name:"Kresimir",surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"8884",title:"Syntheses of Silver Nanowires in Liquid Phase",doi:"10.5772/39491",slug:"syntheses-of-silver-nanowires-in-liquid-phase",body:'\n\t\tNanowires which were defined as having at least two dimensions between 1 and 100 nm, have received a great interest due to their unique optical, electrical, magnetic, and thermal properties with dimensionality and size confinement [1-10]. The intrinsic properties of nanowires are mainly determined by its size and composition. In order to study the size dependent properties, it is the crucial task to synthesize size-controlled nanowires. Among all these nanowires, the synthesis of silver (Ag) nanowires has been and continues to be an area of active research due to the high electrical and thermal conductivities of bulk silver, which is an important material in many fields. Moreover, silver nanowires have also been used as sacrificial templates to generate other nanostructures such as gold nanotubes, which are difficult to be fabricated [9,10]. The research progress in synthesis strategy is mandated by advancements in all areas of industry and technology. In the past ten years, owing to the efforts from many research groups, splendid strategies were developed for the synthesis of Ag nanowires with various levels of control over the growth parameters.
\n\t\t\tThese synthetics strategies have been conveniently categorized into vapor phase approaches and liquid phase growth approaches. Vapor phase approaches mainly utilize physical methods such as an electronic-beam. Limited by the space of the chapter, we lay a strong emphasis on the introduction of liquid phase synthesis of Ag nanowires. Liquid phase syntheses were most widely used because these approaches have the advantages of nature of homogeneous reaction, wide range of solvents, simple monitoring technology, and low cost. In this article, we review some current research activities that center on Ag nanowires. Representative techniques are discussed and supply a basic understanding of the methods and mechanisms for preparing Ag nanowires.
\n\t\tPolyol synthesis was originally introduced by Fievet et al. [11] as an excellent method for the synthesis of submicrometer-sized metallic nanoparticles. Xia and co-workers successfully developed this method to the preparation of single-crystal Ag nanoparticles with uniform size and shape using polyvinylpyrrolidone (PVP) as a protecting agent [12]. Now the polyol method has become widely used by many research groups for the synthesis of metal nanostructures. Xia et al. synthesized Ag nanowires with higher aspects ratios by injection of ethylene glycol (EG) solutions of AgNO3 and PVP, added drop-by-drop, at a constant solution temperature of 160 C [12]. In the polyol process, the introduction of an exotic reagent is considered to be the key factor that leads to the formation of wire-like structures. In their experiments, Ag nanowires are generated using a self-seeding process and EG acts as both solvent and reducing agent. For the formation of silver nanowires, low precursor concentrations and slow addition rates are necessary. By controlling the injection rate, multiple-twined particles (MTPs) formed at the initial stage of the reduction process could serve as seeds for the subsequent growth of silver nanowires, which is the so-called self-seeding process. At a lower precursor concentration, it is possible to reduce the chemical potential to a relatively low level so as to make MTPs thermodynamically stable because it is bound almost entirely by the lower energy {111} facets [13-15]. At the same time, due to the existence of twin defects at the borders of combined tetrahedron, silver atoms will preferentially deposit on those active sites. Once five-twinned particles have been formed, they will change easily from MTPs to silver nanowires. Figs. 1A-1D show the scanning electron microscopic (SEM) and transmission electron microscopic (TEM) images and XRD of the silver nanowires with a large ratio of length to width. It was found that the morphologies and aspect ratios of Ag nanowires strongly depend on the molar ratio between the repeating unit of PVP and AgNO3. When the molar ratio between PVP and AgNO3 was more than 15, the final product was essentially composed of silver nanoparticles. When the molar ratio decreased to 6, the resulted product contained many
\n\t\t\t\tA) SEM and C) TEM images of uniform silver nanowires which were synthesized via the self–seeding polyol process. B) XRD pattern of these nanowires, indicating the fcc structure of silver. D) The TEM image of an individual silver nanowire. The inset gives the microdiffraction pattern recorded by focusing the electron beam on this wire. Reprinted with permission from reference [12f]. Copyright 2002 ACS.
nanorods. Nanowires were synthesized with the molar ratio of 1.5. If the molar ratio was further decreased to 0.6, nanowires become significantly thicker and some of them were non-uniform along the longitudinal axis. It was generally accepted that for a given coordination reagent such as PVP, it can kinetically control the growth rates of various faces of metal through selective adsorption and desorption on these surfaces. An advantage of this method is that large-scaled synthesis of Ag nanowires is possible. It was believed that the synthetic approach described by Xia et al. [12] can be extended to many other metals by selecting appropriate coordination reagents.
\n\t\t\tBased on the PVP-assisted polyol method, Xia and co-workers also developed a salt-mediated polyol process to prepare silver nanowires [12,16]. The addition of a trace amount of salt, such as NaCl, Fe(NO)3, CuCl2 and CuCl, has been shown to influence the morphology of the final metal products. Usually salt-mediated synthesis strategy is a simple and effective method which is useful for the mass synthesis of silver nanowires [16]. For example, they synthesized silver nanowires in high yields by reducing AgNO3 with EG heated to 148 C in the presence of PVP and a trace amount of NaCl. It was found that oxygen must be removed from the reaction solution in the presence of Cl- anions in order to obtain silver nanowires. Fig. 2 shows the proposed mechanism of oxidative etching and growth of MTPs. Five-twinned decahedral particles were proposed to be seeds of Ag nanowires. The defects among single-crystal tetrahedron subunits of decahedral particles provide high-energy sites for atomic addition, leading to one dimensional Ag products via anisotropic growth along the <110> direction. The addition of chloride causes enhanced oxidation and preferential etching of twinned particles, leaving only single-crystal particles (or seeds) to grow. Under the similar conditions, Xia’s experiment has been carried out under argon which supplied an anoxic condition and the twinned particles that formed in the early stage of the reaction could grow into uniform nanowires [17].
\n\t\t\t\tIllustration of the proposed mechanism by which twinned decahedron was etched with the existence of O2/Cl- and silver nanowire was obtained under argon protection.
In another typical synthesis of silver nanowires by Xia et al. [16a], reduction reaction was carried out through a CuCl or CuCl2 mediated polyol process but without introducing any inert gases. Both the cation and anion are necessary for the successful production of silver nanowires. It was found that oxidative etching effect was not observed even at a comparably high Cl- concentration. This result was attributed to a decrease in the amount of dissolved O2 present during the reduction reaction. Fig. 3 shows the role of Cu-containing salts in the polyol synthesis of Ag nanowires. O2 can adsorb and dissociate on silver surfaces and block the {111} reactive sites from adding Ag atoms efficiently [18,19]. Cu(I) [Cu(II) can be reduced into Cu(I) by EG] effectively scavenge any adsorbed atomic oxygen from the surface of silver seeds and benefit the growth of silver nanowires. These results suggest that silver nanowires can be achieved more rapidly when oxygen is most effectively removed. A trace amount of Cl- also acts an important role in the polyol synthesis of silver nanowires. Firstly, it provides electrostatic stabilization for the initially formed silver seeds. Secondly, Cl- can reduce the concentration of free Ag+ ions in the solution through the formation of AgCl nanocrystallites and supply a slow release process of Ag+ which facilitates the high-yield formation of the thermodynamically more stable MTPs required for wire growth.
\n\t\t\t\tA schematic illustration depicting the role of Cu-containing salts in the polyol synthesis of Ag nanowires. Molecular oxygen present during initial seed formation can adsorb and dissociate on the Ag seeds. Cu(I) rapidly scavenges this adsorbed atomic oxygen (Oa).
All previous reports of the synthesis of silver nanowires from an AgNO3/Cl-/PVP/EG solution described that it is necessary to remove the oxygen dissolved in the reaction solution in order to achieve the growth of silver nanowires. Recently, our group [20-23] and Gou et al. [24] found that the mechanism described above is not applicable to the synthesis of Ag nanowires under rapid microwave(MW)-polyol method in the presence of Cl- anions because one dimensional (1D) structures were produced preferentially from unstable decahedrons even in the presence of O2. It was predicted that not only Cl- from NaCl, but also O2 dissolved in EG probably takes part in the shape-selective evolution of Ag 1D products.
\n\t\t\t\tWe extended the MW-polyol method to an air-assisted method which is carried out in an oil-bath tank. In general, mixtures of nanowires and other spherical and cubic particles are prepared in the polyol synthesis. Therefore, centrifugal separation between nanowires and other products was necessary to obtain nanowires. We have recently prepared Ag nanostructures under bubbling air or N2 gas [25]. Then, we succeeded in the synthesis of monodispersed silver nanowires in high yield (>90% without isolation) under bubbling air through a reagent solution under oil-bath heating from ca. 20 C to the boiling point of EG (198 C) for 20 min. Fig. 4 depicts typical TEM images of Ag nanowires obtained under bubbling air and N2. Long nanowires of uniform diameters of ca. 40 nm and lengths of 5–30 μm could be obtained under bubbling air without centrifugal separation of other particles (Figs. 4a and 4B). On the other hand, mixtures of cubes, bipyramids, and wires were prepared under bubbling N2 (Figs. 4C and 4D). The yield of 1D particles is only 20% because of high yields of cubes and bipyramids under bubbling N2. Similar Ag nanostructures were obtained when we prepared Ag nanostructures without gas bubbling. The yield of nanowires (75%) was an intermediate value between that obtained undr bubbling air (90%) and that under bubbling N2 (20%). This result can be attributed to that a small amount of residual O2 gas is dissolved in EG without gas bubbling. It takes part in the production of each Ag nanostructure.
\n\t\t\t\tTypical TEM images of Ag nanostructures prepared from AgNO3 (46.5 mM)/NaCl (0.3 mM)/PVP (264 mM)/EG mixtures at 198 C by bubbling of air (A and B) and N2 (C and D). Also shown are crystal structures of 1D products, cubes, and triangular bipyramids.
The growth process of silver nanostructures was also studied by observing ultraviolet–visible (UV–Vis) spectra and TEM images at various temperatures. It is well documented that Ag nanostructures display different SPR bands with different frequencies depending on shapes and sizes, as reviewed by Mock et al. [26] and Wiley et al. [27]. The main SPR peaks for Ag nanorods and nanowires appear at ca. 350 and ca. 380 nm as shown in Fig. 5A at 198 C. These peaks were attributed to the transversal modes of the 1D products with pentagonal cross sections, corresponding respectively to the out-of-plane quadrupole resonance and out-of plane dipole resonance modes. The SPR bands of cubic (ca. 80 nm edge length) and triangular bipyramidal (75 nm edge length) Ag crystals were observed respectively at 320–800 nm with a peak at ca. 470 and 320–900 nm with a peak at ca. 520 nm [12,26,27]. The peaks described above mutually overlap when mixtures of Ag nanostructures of various shapes and sizes were prepared.
\n\t\t\t\tUV-Vis spectra of Ag nanostructures prepared from AgNO3/NaCl/PVP/EG mixtures under bubbling of (A)air and (C) N2. Also shown are typical TEM images of Ag nanostructures obtained by bubbling of (B) air and (D) N2 at 180 C.
To examine the shape evolution of Ag nanostructures through bubbling air and N2, the UV–Vis absorption spectra of the reagent solutions were measured at various solution temperatures (Figs. 5A and 5C). UV spectra obtained under bubbling air and N2 are similar at low temperature. A symmetrical SPR band with a peak at ca. 410 nm appears at ca. 100 C and becomes strong and broad up to ca. 175 C. This suggests that the formation of spherical nanoseeds and the sizes become large with the increase in temperature. With increasing temperature from 175 to 180 C, the SPR peaks become broad and three peaks appear at 355, 410, and 440 nm. The two former peaks are ascribable to SPR bands of 1D Ag nanoparticles; the last one can be assigned to SPR bands of quasi-cubic and quasi-bipyramidal structures. To confirm morphologies of Ag nanostructures at 180 C, TEM images of products were measured for bubbling of N2 and air (Figs. 5B and 5D). An outstanding finding is that there is no marked difference in yields of respective products obtained under bubbling air and N2 at 180 C. On the other hand, it was found that the growth rate of 1D product is much higher than those of cubes, bipyramids, and spheres in the 180–198 C range for both bubbled gases; growth is especially rapid under bubbling air. Furthermore, the last peak of the cubes and bipyramids disappears at 198 C, which indicates the yields of cubes, bipyramids, wires, and spheres are much lower under bubbling air in the 180–198 C range.
\n\t\t\t\tBased on the above findings, we proposed the mechanism of the Ag nanostructure formation under bubbling N2 and air (Fig. 6). The reaction process was separated into two stages. The first stage is from room temperature to ca. 180 C and it need about 16 min to finish this process under oil-bath heating at 500 W; seed nucleation and formation take place at this low temperature range. The solubility constant of AgCl in EG is very small at a room temperature (ca. 20 C). Therefore, there is little free Cl- anion existed in the solution and almost all Cl- from NaCl is present as small AgCl nanoparticles. These indiscerptible AgCl particles can serve as seeds of Ag anisotropic nanoparticles. With increasing the temperature from room temperature to 180 C, AgCl is dissolved gradually in EG and much Ag+ and Cl- are released to the reaction solution, which supply reducing materials to neutral Ag. In a separate experiment we have confirmed that Ag nanoparticles are actually produced directly from AgCl by heating an AgCl solution from room temperature to 180 C. This result indicates that AgCl is dissolved and reduced to Ag. It finally provides small Ag nanoparticles in EG in this temperature region.
\n\t\t\t\tProposed mechanism of Ag nanostructures synthesized from AgNO3/NaCl/PVP/EG mixtures using bubbling of N2 and air.
In the first stage in Fig. 6, the Cl- concentration is low so that oxidative etching rates are slow. Under such conditions, the etching rate is insufficiently high to etch small Ag particles. Therefore, effects of gas are unimportant, and mixtures of cubes, bipyramids, and rods are produced in both bubbling of N2 and air at temperatures less than ca. 180 C. The second stage is the high-temperatures from 180 to 198 C. In this range, the etching rate increases with the increasing in the concentration of Cl-. Thereby, oxidative etching rates become so high that small Ag particles can be etched in the presence of O2. In this range, the growth rates of Ag seeds also increase considerably: rapid crystal growth and oxidative etching occur competitively. The relative rate of crystal growth and oxidative etching strongly depends on shapes of Ag particles. In this condition, the growth rate from decahedra to 1D products is fast, whereas the etching rates of other products are fast. Therefore, Ag nanowires are produced in a high yield.
\n\t\t\t\tIn general, shapes of the final products depend not only on the stability of crystal structures against etching by Cl-/O2 but also the density of Ag0 atoms around the growing nuclei. A high related ion concentration around the nuclei can create an environment with high twinning probability for the formation of MTPs from which pentagonal 1D rods and wires are grown. Thus, five-twinned 1D products are favorable at higher concentration of Ag+ ions, whereas single crystal cubes are preferentially formed at lower concentration of Ag+ ions.
\n\t\t\t\tIn order to further confirm the effect of NaCl in the synthesis of silver nanowires, a series of experiments were carried out without gas bubbling [28]. First Ag nanostructures were prepared at various NaCl concentrations from 0 to 0.45 mM. We found that the concentration of NaCl strongly affects the final shapes of products. A low concentration of NaCl (0.12 mM) is in favor of the formation of cubes and bipyramids, whereas a higher concentration of 0.3 mM is the best condition for the formation of NaCl nanowires.
\n\t\t\t\tWe classified mechanisms for the formation of Ag nanostructures into three cases as shown in Fig. 7, depending on the molar ratios of [NaCl]/[AgNO3]. Case (a) is [NaCl]/[AgNO3] = 0. When the NaCl is absent, Ag+ ions are reduced to Ag0, nucleation occurs, and then the Ag seeds are formed and their growth leads to spherical particles formed randomly. Case (b) is [NaCl]/[AgNO3] = 1. When equal molar concentrations of AgNO3 and NaCl are mixed at room temperature, AgCl is formed due to the small solubility constant of AgCl. In this case, AgCl is dissolved as Ag+ and Cl- with increasing temperature. After then Ag+ ions are reduced to Ag0 and nucleation, seed formation, and crystal growth take place. Since the concentration of Ag+ ions is low, twinning probability is low. Therefore, single crystal cubes and single-twin bipyramids are produced preferentially. Case (c) is an intermediate between the above two cases: [NaCl]/[AgNO3] = 0.0065. In this case, although AgCl is formed, a large excess amount of AgNO3 is present in the solution. The standard electrode potential of AgCl + e- → Ag + Cl- (+0.2233 V vs. SHE) is lower than that of Ag+ + e- → Ag (+0.799 V vs. SHE). Under such a condition, most of the Ag0 atoms do not arise from AgCl but from free Ag+. In this case, major products are five-twinned 1D particles because the concentration of Ag+ ions is sufficiently enough to provide a high probability for twinning.
\n\t\t\t\tPossible nucleation and growth mechanisms of Ag nanostructures at different molar ratios of [NaCl]/[AgNO3].
In the case of the liquid phase method, previous studies on anisotropic growth of Ag nanomaterials have demonstrated that Pt seeds as exotic nuclei play a key role with PVP served as a capping reagent. Xia et al. have described a soft template assisted solution-phase approach for the production of 1D nanostructures by reducing AgNO3 in the presence of PVP and PtCl2 in EG at a high temperature using oil bath [29]. They have suggested that the formation of the 1D Ag nanostructures proceeds via two steps. The first step involve the formation of Pt nanoparticles with an average diameter of 5 nm by reducing PtCl2 with EG.
\n\t\t\t\tAt second step, AgNO3 and PVP are added into the reaction system drop-by-drop, leading to the nucleation and growth of Ag nanowires. They thought that the pre-synthesized Pt nanoparticles serve as seeds for the heterogeneous nucleation and growth of silver owing to the close match in crystal structure and lattice constants. Then Ag nanoparticles with diameters of 20-30 nm were created following the nucleation process. Many Ag atoms also nucleated through a homogeneous process and formed critical particles with diameter of 1-5 nm. At high temperature, critical particles progressively disappeared to benefit the growth of large particles via the famous Ostwald ripening [30]. With the assistance of PVP, some of the large particles grow into nanowires with diameters in the range of 30-40 nm. Usually the growth process would continue until all these critical silver particles with diameters less than 5 nm were completely consumed, and only nanowires and larger nanoparticles can survive stably.
\n\t\t\t\tOur group have conducted a further detailed study on the real role of Pt seeds as a nucleation regent for the preparation of 1D Ag nanostructures by using the MW-polyol method [23]. To examine effects of Pt seeds and Cl- anions, a various kind of experiments were carried out. When Pt catalysts were prepared from two different agents, H2PtCl66H2O and Pt(acac)2, the 1D Ag nanostructures could be easily prepared only by using H2PtCl66H2O, although Pt seeds could be produced when using either of them. This result might indicate that Pt catalysts probably do not act as seeds for evolution of the 1D Ag nanostructures. In contrast, it is possible for Cl- ions resulting from H2PtCl66H2O to play an important role in assisting the formation of the 1D Ag nanostructures. So we used NaCl or KCl as a source of Cl- ions to elucidate the role of Cl- ions. We found that nanowires could be prepared when using either of them. In addition, besides the 1D Ag products, the formation of some well-crystallized cubic and bi-pyramid Ag nanocrystals with sharp edges has been found to be related to existence of Cl- ions. We confirmed that the so-called Pt seeds-mediated process is in fact a salt-mediated polyol process.
\n\t\t\tMurphy et al. firstly reported the large-scaled preparation of silver nanowires with uniform diameter by seed-mediated growth approach in a rod-like micellar media [31]. In principle, two steps were necessary in order to achieve the formation of nanowires. Firstly, Ag nanoseeds with an average diameter of 4 nm were prepared by chemical reduction of AgNO3 by NaBH4 in the presence of trisodium citrate. Then AgNO3 was reduced by ascorbic acid in the presence of Ag seed obtained in the first step, the micellar template cetyltrimethylammoniun bromide (CTAB), and NaOH in order to synthesize nanorods and nanowires with various aspect seed. This seed-mediated growth approach is prone to form silver nanorods and nanowires of controllable aspect ratio.
\n\t\t\t\tIt is well documented that Ag nanowires were one of the earliest twinned Ag nanostructures reported and now have become an active area of research in Ag nanoparticles. But it was always a great challenge to achieve control over the length and width of Ag nanorods and nanowires. At the same time, silver nanorods and nanowires with pentagonal cross-section have been proposed to come from the evolvement of decahedra. Recently, Kitaev et al. synthesized monodisperse size-controlled faceted pentagonal silver nanorods by thermal regrowth of decahedral silver nanoparticle in aqueous solution at 95 C, using citrate as a reducing agent [32]. Here we will introduce this method although it is a synthesis method of Ag nanorods. Firstly monodisperse decahedral Ag nanoparticles were synthesized by photochemical method and the size of decahedron can be controlled in a larger scale range by regrowth. Then, silver decahedra were added into a temperature-controlled solution and a thermal regrowth was carried out at 95 C with the presence of PVP with citrate as a reducing agent. Fig. 8 shows the typical SEM images of the resulted monodisperse pentagonal Ag nanorods. These faceted pentagonal rod particles readily self-assemble into densely packed arrays upon drying of their dispersions owing to the excellent monodispersity and good stabilization in aqueous solution. It was found that PVP can improve the yield and stability of Ag nanoparticle, but not absolutely necessary for the shape control. Ag nanorods with various aspect ratio of length to diameter can be achieved by semicontinuous silver addition and the width of nanorods was determined by the size of decahedron. Due to the ease of preparation and excellent shape and size control, this method is well worth further studying and can be extended to the synthesis of Ag nanowires in the future. These nanorods will be attractive for diverse practical applications due to the reliable synthetic approach, high monodispersity, excellent size control.
\n\t\t\t\tSEM images of self-assembled packing of monodisperse pentagonal Ag nanorods. Reprinted with permission from renference [32]. Copyright 2009 ACS.
Before the work of Kitaev et al. [32], silver nanorods and nanowires have also been synthesized in our group using multiple twin decahedron (MTD) of gold as the seed by the MW-polyol method [33]. Because gold and silver have the same FCC crystal structures, and the lattice constants of Au (0.4079 nm) and Ag (0.4086 nm) are very similar, there are many kinds of Au@Ag core-shell structures can be prepared from Au/Ag reagents. The final shape of Ag outer shell was decided by the shape of Au inner core. The Au@Ag core-shell nanostructures were synthesized in two steps. The first step was the synthesis of an Au inner core, and the second step was the preparation of an Ag outer shell including nanorods and nanowires. Fortunately, the thin boundary layers of Au@Ag core-shell structures can easily be observed from TEM images, because Au cores and Ag shells appear as clear black and blight contrasts, respectively. Based on the TEM observation of Au@Ag particles prepared at different [Ag]/[Au] molar ratios (Fig. 9) and EDS data, the growth mechanism of Au@Ag nanocrystals overgrown on an MTD Au core was illustrated in Fig. 10. The MTD nanocrystals consist of ten {111} facets and crystal growth occurs in two opposite <110> directions with the same growth rates. Because PVP molecules selectively adsorb on the surface of five rectangular side {100} facets and, crystal growth occurs on the exposed active {111} facets. Thus Ag shells are continuously overgrown on MTD particles along <110> directions because active {111} facets with a constant total area remain during the crystal growth. During our studies on core-shell nanocrystals, we have found that Ag rods and wires are overgrown on the MTD Au crystals located in the center of the 1-D particles. This result provides the first definite experimental evidence that the previously proposed growth mechanism of 1-D Ag nanorods and nanowires is valid. It was found that optical properties of Au@Ag nanocrstals are different from that of pure Au core and Ag shell nanocrystals, they can be applied to a new optical device.
\n\t\t\t\tTEM photographs of Au@Ag nanorods and nanowires prepared by addition of various amounts of AgNO3 to Au cores.
Growth mechanism of Au@Ag nanorods and nanowires from the decahedral Au core.
Previous strategies to control the growth of Ag nanowires have involved either softer directing agents, including surfactants or polymers. It is hard work to remove the directing agent from nanowires surface because multiple washings are required. For some sensing applications, the surface-bound residue from the synthesis increases the difficulty of doing chemistry at the surface. Murphy and co-workers reported a method to make crystalline silver nanowires in water, in the absence of a surfactant or polymer to direct nanoparticle growth, and without externally added seed crystallites [34]. The reaction is one in which silver nitrate is reduced to silver metal at 100 C by sodium citrate in the presence of NaOH. Hydroxide ion concentration was an important factor in determining the morphology of the final product. Ag nanowires prepared by this method is up to 12 microns long. In this synthesis, the citrate plays multiple roles. It not only strongly complexes with the silver ion but it is also responsible for the reduction to silver metal and acts as a capping agent to the silver metal. Although only small amount of hydroxide exists in the reaction solution and hydroxide weakly complexes with the silver ion, but it is enough to interfere with the capping ability of citrate and lead to the formation of Ag nanowires. It is a simple method to prepare nanowires of silver in high yield, with relatively few spherical nanoparticle byproducts. Most importantly, it does not require a surfactant or polymer template, or seeds. This method makes it possible to prepare metallic nanostructures with as “clean” surfaces in water.
\n\t\t\tSurfactant assisted synthesis is one of the soft-template processes. Murphy et al. have successfully synthesized silver nanorods or nanowires with a rod-like micelle template in CTAB assisted process [31]. During their experiment procedure, seeds are also required in order to achieve the growth of nanorods or nanowires as described in 2.3, so the reaction system becomes complicated. For the surfactant approaches, when the concentration of surfactant is above the critical concentration, micelles with a certain shape will form and act as a soft template. Nanorods and nanowires with controllable aspect ratio are fabricated with the absence of seeds. If the surfactant concentration is too low to form any micelles, it only acts as a capping agent or dispersing agent. Murphy and coworkers also reported the seedless and surfactantless wet chemical synthesis of silver nanowires, in which tri-sodium citrate serves as a capping agent and reducing agent [34] as shown in 2.4. The limitation of surfactantless approach is that it can’t well control the dimensions and morphologies of the product and nanowires obtained with this method are poorly dispersed.
\n\t\t\t\tTian and co-workers developed a seedless surfactant process to synthesize high-quality Ag nanorods and nanowires in large quantities [35]. Silver nitrate is reduced by tri-sodium citrate (Na3C6H5O7) in the presence of sodium dodecylsulfonate (SDSN). In this process, tri-sodium citrate plays an important role, and SDSN only acts an assisting role as a capping agent in the formation of Ag nanowires. The concentration of SDSN actually used in the experiment process of Ag nanowires is only 1 mM, which is far lower than the critical concentration for the formation of spherical micelles (9.7 mM, 40 C). Especially, the critical concentration of the micelle formation for SDSN increases with temperature rising. So there are no SDSN micelles formed to serve as a soft template during the whole process of forming nanostructures. The diameters and aspect ratios of Ag nanowires or nanorods can be controlled by changing the concentration of tri-sodium citrate. However, it does not mean that SDSN is unnecessary for the formation of nanorods or nanowires. Ag nanowires cannot generate under too-low or too-high concentration of SDSN. The key to form Ag nanowires is to well control the tri-sodium citrate concentration for a fixed SDSN concentration.
\n\t\t\t\t\n\t\t\t\t\tFig. 11 shows the proposed schematic illustration for the growth of Ag nanorods and nanowires. At a lower concentration of tri-sodium citrate below 0.2 mM, Ag monomer concentration favors the formation of nanospheres according to Ostwald ripening and small particles dissolve into the solution and deposit on large particles. At a higher concentration of tri-sodium citrate beyond 0.2 mM, a large quantity of monomers is produced in the solution and the growth mode is diffusion-controlled. The monomer concentration in the stagnant solution keeps the solubility of the (110) facet by a rapid growth onto or dissolution from the facet in the assistance of SDSN. It is well documented that the activation energy of the (110) facet is lower than that of (100) and (111) owing to the relative high surface free energies for a FCC structured metal particle. Therefore, monomer particles grow up along <110> directions owing to the strong bonding abilities and chemical reactivities of (110) facet. Thus nanorods are obtained. At higher concentration tri-sodium citrate (>0.8 mM), nanowires with smaller diameter and higher aspect can be formed because of the higher Ag monomer concentration and high velocity of crystal growth.
\n\t\t\tSchematic illustration of the experimental mechanisms to generate spherical, rod- and wire-like nanoparticles.
In recent years, coaxial nanocable as a new nanostructure has also received great attention because their functions could be further enhanced by fabricating the core and sheath from different materials, which will find use as interconnects in fabricating nanoelectronic devices. Ag-polymer nanocables became a major focus of cable-shaped nanostructures, due to its extremely high electrical conductivity in the bulk and its unusual optical properties depending on the size. It has also been predicted that Ag nanowires with polygonal or circular cross sectional symmetry would exhibit different resonances and a dielectric coating would lead to a red-shift of the SPR peak [36,37]. According to the traditional crystal-growth theory, it is impossible to form Ag nanowires with circular cross-section. Cable-like structures make it possible for the formation of nanowires with expected cross-sections. Then many approaches were developed to achieve Ag nanocables.
\n\t\t\tXia’s group first reported the preparation of Ag nanocables by directly coating bicrystalline silver nanowires with conformal sheaths of silica through a sol-gel process [38]. Yu et al. [39] introduced a simple large-scale hydrothermal synthesis of flexible nanocables with silver as cores and cross-linked poly(vinyl alcohol) (PVA) as shells. In a typical procedure, a clear solution containing 0.06 mM AgNO3 and 5 mL PVA (3 wt %) solution was added into Teflon-lined stainless steel autoclave, which was sealed and maintained at 160 C for 36 or 72 h and then cooled to room temperature naturally. The resulting product is composed of flexible fibers with a diameter of 0.7-4 µm and length up to 100 µm (Fig. 12a). All these silver nanowires show a composite structure of a smooth core and a surrounding sheath (Figs. 12b-12e). At the same time, it is well distinguished between surrounding polymer and inner core. The shell thickness of the obtained nanocables is decided by the reaction time and the temperature can also affect the thickness of the shell. It is well worth noting that PVA cannot become cross-linked in the absence AgNO3 after a hydrothermal treatment and keep other parameters constant, which indicate that AgNO3 is essential for the formation of cables. In fact, AgNO3 acts as a catalyst for oxidation-reduction reactions and PVA can be oxidized by AgNO3 at 160 C into cross-linked PVA. It is promising to extend this method to the synthesis of other metal-polymer coaxial nanocables.
\n\t\t\tSEM and TEM images of the nanocables. (a) General view of the cables. Inset is the sample obtained after reaction for 72 h. (b) Magnified SEM image of the cables, clearly showing the inner core-shell structure. (c-e) TEM images of the cables. Reprinted with permission from reference [39]. Copyright 2005 ACS.
Li et al. achieved the synthesis of cylindrical Ag nanowires by using an amorphous coating to modify the growth behaviour of Ag nanowires [40]. In their synthesis, Ag+ ions are reduced by glucose under hydrothermal conditions with the presence of PVP in the temperature range of 140-180 C. These resulted Ag nanowires at 180 C show a narrow diameter distribution of 16 to 24 nm and the lengths usually reach tens of micrometers. Such slim nanowires show excellent flexibility, which indicates good machinability for future nanodevice fabrication. Further insight to the structure was obtained by high-resolution TEM, which showed Ag nanowires are coated by a multilayer sheath and cable-like structures are created. The sheath should be composed of carbonaceous layers according to previous study that carbonization of glucose could take place under similar conditions. For the formation of Ag@C nanocables, they proposed that Ag nanowires first grew up and then carbonaceous growth units stick on the edges of polygonal crystals owing to the higher surface tension and more dangling bonds. At a low reaction temperature of 140 C, only well-crystallized pentagonal nanowires were obtained. This reason can be attributed to that carbonization process is significantly delayed. In summary, high-purity cylindrical Ag nanocables can be selectively prepared through kinetic control of the hydrothermal conditions.
\n\t\tFabrication of silver nanowires has a special significance in many applications, since the optical properties of silver show superior properties compared to that of any other metals with respect to the losses in the localized surface plasmon resonance, or in the propagation of the one-dimensional surface plasmons. The fact that silver nanowires are excellent conductors of both electrons and photons opens up intriguing possibilities for electro-optical devices. Due to high electrical conductivity, silver nanowires are also promising materials as ultra large-scale circuits and quantum components, as well as for electron field emission sources in FEDs (field emission displays).
\n\t\t\tThis article gave a simple introduction to the synthesis methods and growth mechanisms of Ag naowires, which were developed in the recent ten years by many research groups. Silver nanowires as the most typical metal nanowires has become an important branch of metal nanowires, and these methods used for the synthesis of Ag nanowires can supply reference for the synthesis of other metal nanowires. Every approach involved in this article has the merit and disadvantage, but all of them can give us some elicitation which will benefit to explore new strategies in the future.
\n\t\tThis work was supported by Joint Project of Chemical Synthesis Core Research Institutions, and Grant-in-Aid for Scientific Research on Priority Areas "unequilibrium electromagnetic heating" and Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Nos. 19033003 and 19310064).
\n\t\tLeiomyomas are benign smooth muscle tumours usually arise from the uterus [1]. Classical uterine leiomyoma manifest as firm, well circumscribed mass, and localized to the pelvic cavity [2]. Extrauterine leiomyomas (EULs) are very rare and their etiology is not clear [1]. They grow in unusual patterns and locations, thus possess greater diagnostic challenge. Different presentations of EUL are disseminated peritoneal leiomyomatosis (DPL), parasitic leiomyoma (PL), uterine-like mass lesions, adenomyoma and endomyometriosis [3]. Unusual sites involvement like vulval and rectovaginal leiomyomas are also found [4]. EULs arising in the gastrointestinal tract, genitourinary tract, as well as other rare locations including sinonasal cavities, orbits, and skin are also described in some case reports.
\nUterine leiomyoma is a benign tumour which originates from smooth muscle cells. Leiomyomas can present in abnormal growth patterns and tend to occur in extrauterine location especially in cases with prior history of hysterectomy or surgery for uterine leiomyomas.
\nMultifocal proliferation of multiple smooth nodules throughout the peritoneal surface histologically similar to uterine myomas is known as leiomyomatosis peritonealis disseminate (LPD) or disseminated peritoneal leiomyomatosis (DPL) [3, 5, 6]. The peritoneal cavity shows multiple nodules of smooth muscle (Figure 1) [6, 7]. DPL usually occurs in reproductive age group with an indolent course, and are mostly detected incidentally [6]. Uterine myoma morcellation is a known risk factor for the development of DPL with an incidence rate around 0.12 to 0.95% after morcellation [5, 6]. Morcellation may lead to spreading of cellular materials of the myoma fragments. These morcellated tissues get disseminated if they are not removed and may become infarcted, necrotic or even parasitic [3]. Other causes which can contribute in the pathogenesis of DPL includes; hormonal, genetic, and sub-peritoneal mesenchymal stem cells metaplasia.
\n(A) Contrast-enhanced T1-weighted fat-suppressed fast spin echo magnetic resonance image shows multiple homogeneously enhancing peritoneal leiomyomas (arrows), (B) Intra-operative gross image showing multiple variably sized peritoneal nodules representing disseminated peritoneal leiomyomatosis.
Pelvic region is the commonest site especially in pouch of douglas, may also spread to entire abdomen to involve omentum and mesentery. DPL is very invasive and very difficult for complete surgical excision, which may invade into bladder, retroperitoneal space, liver and small bowel [5]. They present as numerous subcentimetric grey -white firm nodules, sometimes with solid cystic hemorrhagic changes [5]. DPL can presents with ascites and adenopathy, which can be confused with peritoneal carcinomatosis. Sometimes, DPL may evolve into leiomyosarcoma, though it is extremely rare and possess high mortality rate [5, 6]. Due to unusual multifocal presentation, peritoneal myomas mimic malignant peritoneal tumor, so aggressive treatment at first surgical line should be avoided [6].
\nSome cases of gastrointestinal tract (GIT) leiomyomas have been reported with intestinal obstruction or bleeding without past or present history of uterine fibroid. But GIT leiomyomas are different from LPD. GIT leiomyomas can develop from intestinal wall and may reach the lumen whereas LPD mostly reach peritoneal cavity and omentum [5]. But disseminated GIT leiomyoma could be related to LPD, if there is no evidence of uterine myomas [5].
\nBenign metastasizing leiomyoma (BML) is a rare condition that affects women with a history of uterine myomectomy, which is found to metastasize to extra-uterine sites. The disease is characterized by monoclonal proliferation of smooth muscle cells and haematogenous spread from uterine leiomyoma to distant locations, most commonly the lungs (Figure 2) [2, 8]. The other uncommon site of metastasis includes heart and spinal cord [2]. Metaplastic transformation of the coelomic epithelium may explain BML in almost any place where mesothelial mesenchyme exists [2]. BML commonly occur during peri-menopausal period. Surgical excision is the treatment of choice.
\n(A) Abdomino-pelvic computed tomography showing a large pelvic mass, and (B) thoracic computed tomography showing bilateral lung nodules, Gross specimens (C) pelvic mass excision and (D) video-assisted thoracoscopic guided surgical resection of bilateral basal lung nodule in an operated case of total abdominal hysterectomy with bilateral salpingo-oopherectomy.
Intravenous leiomyomatosis (IVL) also included under smooth muscle tumours with unusual growth pattern like that of benign metastasizing leiomyoma (BML) and diffuse peritoneal leiomyomatosis (DPL) and difficult to distinguish from them [2]. IVL is very rare variant of benign leiomyomas. It presents as fragile and malleable leiomyoma that extends through adjacent venous structures in a worm-like fashion (Figure 3) [2]. Rarey, IVL may infiltrate into the right heart chamber and the lungs [6]. Due to wide range of clinical manifestation, IVL is difficult to diagnose pre-operatively [2].
\n(A) Magnetic resonance image showing a ‘comma’ shaped thrombosis, extending from the intrahepatic portion of inferior vena cava (IVC) to the right atrium, (B) Echocardiography showing an intracardiac mass with dynamic movement past the tricuspid valve into the right ventricle, (C) Gross specimen of total abdominal hysterectomy with left salpingo-oophorectomy, and IVC and intracardiac mass.
Parasitic leiomyoma is termed when leiomyoma especially subserous fibroid is pedunculated off the uterine serosa or when fragments of a fibroid detach, get implanted and grow within the peritoneal cavity or becomes adherent to other structures, especially the omentum (Figure 4) [3]. They obtain their blood supply from nearby organ and the uterine pedicle either or become avascular and disappear completely. These are also known as ectopic leiomyoma [3]. Cucinella et al. suggested morcellated hysterectomies or myomectomies as an important cause for development of parasitic leiomyoma [9].
\n(A) Magnetic resonance image showing two large lobulated peritoneal masses with similar signal and enhancement characteristics, (B) Gross specimen of peritoneal fibroid vascularized by omental vessels in a patient underwent laparoscopic myomectomy 5 years earlier.
Extrauterine adenomyomas (EUA) are benign tumours composed of smooth muscles, endometrial glands and endometrial stroma (Figure 5) [10]. In the literature, four hypotheses have been proposed for the development of EUA which includes (1) Müllerian duct fusion defect - the failure of fusion of Müllerian ducts result in either duplication or atresia of the uterus which is suggested by the formation of uterine-like masses, (2) Subcoelomic mesenchyme transformation - Subcoelomic mesenchyme is a layer of tissue that lies underneath the mesothelial surface of the peritoneum. It also lies underneath the subserosal stroma of uterus, uterine ligaments, ovaries and fallopian tubes, (3) Müllerianosis - It is a heterotopic Müllerian rests incorporated into other organs during organogenesis which may proliferate in response to hormones and (4) Endomyometriosis - along with endomyometriosis, smooth muscle hyperplasia or metaplasia leads to EUA [11, 12].
\nIntra-operative laparoscopic images of (A) pararectal adenomyoma and (B) right ovarian adenomyoma, histopathology images of ovarian adenomyoma (C) low power and (D) high power delineating smooth muscle bundles with embedded endometrial glands in a patient underwent laparoscopic myomectomy 5 years earlier.
Leiomyomas are clonal neoplasm and express more number of estrogen and progesterone receptors in comparison to normal myometrium [1, 2]. Circulating estrogen, progesterone and other growth factors like epidermal growth factor and insulin like growth factors are involved in the growth of uterine leiomyomas [1]. Estrogen stimulates the growth of leiomyoma independent of its location whether uterine or extrauterine [1]. However, the role of progesterone remains uncertain in extrauterine leiomyoma and it’s serum levels are either normal or low. Withdrawal of progesterone and of sex steroid down regulates expression of estrogen receptors (ER) in both leiomyomas and myometrium. This indicates that progesterone and progestins have a dual role on leiomyomas. First, limitation of the tissue response due to blocking of ER replacement and leading to unopposed estrogenic growth effect either by direct stimulation or by increased expression of progesterone receptors (PR). Second, progesterone may leads to an intrinsic growth-stimulation [1]. Progesterone causes increased mitotic division causing myoma growth and leads to the higher propensity for development of the somatic mutations in the myomas. It is suggested that PR is highly expressed in leiomyomas occurring in the reproductive period [1]. Such hormones influence rapid increase in size of leiomyoma in pregnancy which may lead to fetal wastage. However, there is lower expression of PR in EUL than in UL suggesting that different factors may contribute to the development of these tumours. Sen et al found a significant difference for labeling indices of PR between UL and EUL, however it was not significant for ER. Thus, therapeutic models targeting PRs may not be effective on EUL.
\nPatient may present with menorrhagia, or diagnosed incidentally with the history of previous myoma or myomectomy [3]. Ultrasound is useful for diagnosis of uterine fibroid. Prior diagnosis of extra-uterine fibroids is often difficult owing to non-specific clinical and radiological findings. MRI is very helpful when ultrasound shows poor delineation, and in case of rapidly growing fibroid suspicious for malignant transformation. MRI is also very useful for the diagnosis of DPL as well as to determine its extent of spread for surgical planning (Figure 1A) [3]. In case of IVL, apart from trans-vaginal ultrasound, and other modalities such as pelvic MRI, trans-thoracic echocardiography, abdomen or chest computed tomography (CT), and positron emission tomography (PET) are beneficial [2]. But there is limitation of MRI in locating retroperitoneal leiomyoma in which exact anatomical location can be often ascertained only intraoperatively [3]. Few cases may turn into leiomyosarcoma. Peritoneal cytology should be done in case of ascites [3].
\nDespite the extrauterine manifestation of leiomyoma, benign leiomyomas can be distinguished from leiomyosarcoma histologically. Sarcoma is marked by high grade cellular atypia, mitotic index of greater than 10, and presence of coagulative tumor cell necrosis [2]. IVL, usually found within uterine venous channels and microscopically shows benign appearing smooth muscle cells with low mitotic activity which stain for actin and desmin [2].
\nRecent investigations showed that IVL and BML share the same cytogenetic origin, demonstrated by comparative genomic hybridization, clonal number, and copy variance [2]. Leiomyoma and leiomyosarcoma both shows smooth muscle differentiation, however biologically they are different in relation to clinical, cytogenetic, and molecular features [13]. MED12, the mediator complex subunit 12 gene, is a recently described oncogene found in both primary and metastatic leiomyosarcoma. It is detected in as many as 70% of sporadic uterine leiomyoma [13]. Oncogenic roles of MED 12 gene is also detected in smooth muscle tumours arising in extrauterine locations, however, further validating studies required for confirming its exact role in their pathogenesis [13].
\nComplete surgical excision is considered the mainstay and definitive treatment for EULs [14]. LPD mimics carcinomatosis, so total abdominal hysterectomy along with bilateral oophorectomy is often the preferred surgical treatment [5]. However, spontaneous regression has been also described in few case reports in the literature [5]. Surgical treatment affects reproductive ability in pre-menopausal women, so it should always be planned considering the family planning of the patient. In such situation diagnosis by intra-operative frozen section is very helpful [5]. Young patient in child bearing age group, especially who shows positivity for ER or PR markers in EUL, should be subject to ovary-sparing procedures and might be benefited from adjuvant therapy using GnRH agonist [2]. In histological proven DPL cases, debulking is very effective for relieving symptoms, provided the appropriate evaluation of general health conditions of the patient [5]. In unresectable cases of EULs, a medical treatment with aromatase inhibitors, chemotherapeutic agents or a gonadotropin agonist can be considered [2, 6]. During morcellation, falling pieces of myoma fragments should be avoided and proper attention should be given during removal via the port site. Post morcellation, reverse trendelenburg position should be attempted and thorough inspection with copious peritoneal lavage is recommended to aid the removal of remnant myoma pieces [3]. The Food and Drug Administration guidelines discourage the uses of laparoscopic power morcellation during hysterectomy or myomectomy for the treatment of uterine fibroids [3].
\nA routine follow-up is advised in all the patients of uterine fibroid undergoing morcellation for the development of EUL. Similarly, a long-term follow-up is essential in all the operated cases of EUL, particularly, DPL. In EULs, recurrence, if any, usually occur within 6 months after surgical resection. Since, these tumours are hormone sensitive, they usually show regression after reduction in estrogen exposure like after attainment of menopause. Repeat surgeries for recurrent EULs usually entail greater surgical difficulty and risks including visceral injuries [3].
\nDPL may leads to peritonitis and bowel obstruction which can result into sepsis and gangrene. Also, recurrence is not unusual in DPL cases due extensive involvement of peritoneal cavity. Sometimes, malignant transformation may occur in long standing cases.
\nEULs possess a great diagnostic challenge due to abnormal locations as well as their unusual growth patterns and more commonly associated with the complications in comparison to uterine leiomyomas. Though, histologically they show similarities with their uterine counter parts, however their pathogenesis is different and yet not well understood. These EULs, are hormone sensitive and may regress automatically after the recession of hormonal sources, however, this phenomenon is not universal in all cases. Due to their higher propensity for recurrence and rare malignant transformation a close follow-up is required. A peritoneal cytology and/or frozen section examination is recommended before major surgical procedures in EULs.
\nNone to declare.
\nAuthors declare that all the necessary permissions has been obtained for using the images from the corresponding authors/editors of the concerned articles and all the papers from which these images reproduced has been cited.
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