Part of the book: Geriatrics
Femoral head necrosis (FHN) is a difficult disease to treat. FHN results from an obstruction in the blood supply to the femoral head, which causes death of the bone-forming cells. For effective treatment of FHN, an osteogenic cell supply, revascularization, and provision of initial strength to resist collapse are needed. Evidence of favorable outcomes of cell transplantation therapy for the treatment of FHN is emerging. However, outcomes of treatment are influenced by the underlying FHN etiology and clinical stage. Therefore, understanding the epidemiology, clinical stage, and disease status of FHN is essential to inform treatment planning based on evidence. The aim of the chapter is to present and critically discuss the role of cell replacement therapy for the treatment of FHN based on clinical status.
Part of the book: Advanced Techniques in Bone Regeneration
Cell‐processing procedures are conducted in accordance with Good Manufacturing Practices, and clinical procedures are performed by highly optimised methods. A high‐quality transportation system is essential for safe and effective handling of mesenchymal stem cells (MSCs) between cell‐processing and transplantation stages. For MSC transportation, either frozen cell or non‐frozen cell transportation is performed. There are many requirements for transporting a package by either type of transportation. In frozen cell transportation, some issues have yet to be resolved: the primary receptacle and cryoprotectant reagents. In non‐frozen cell transportation, control of cell metabolism and protection from environmental changes are more serious problems. Stabilisation of temperature, shock resistance, gas control, and an ultraviolet radiation (UVR) shielding technology should be considered. The transportation system should be established in compliance with the guidelines. Both development of a high‐quality transportation package and establishment of a high‐quality transportation system are important for the effective use of MSCs in clinical applications.
Part of the book: Mesenchymal Stem Cells