Dr. Chung-Lun Lu graduated from the Institute of Fisheries Science, National Taiwan University, Taiwan, and is a researcher at Aquaculture Technology Research Center, Agricultural Technology Research Institute. Dr. Chung-Lun Lu is a pioneering researcher in aquaculture sciences. He published many papers and books in aquaculture science. He is actively engaged in academic research in Taiwan, including the development of high-value agricultural materials and assay platforms, etc.
Part of the book: Protein Structure
β-Glucan and triterpenes are two important derivative compounds from traditional medicinal mushroom, such as Ganoderma lucidum and Antrodia cinnamomea. β-glucan and triterpenes are considered to have immunoregulatory properties in disease treatment for long years. The immunoregulatory effects are usually activated through some transcription of pro-inflammatory genes and possess immunomodulatory activity. Difficulty in healing wound now is a common condition that occurred in diabetic patients, and the physiological hyperglycemic status of diabetic patients resulting in the wounds continue to produce an inflammatory response. Thus, we hope to use β-glucan and triterpenes for difficult wound healing that possess immunomodulatory activity on the wound micro-environment and stimulate the positive effects on healing. In this chapter, these two important derivative compounds from traditional medicinal mushroom were examined by diabetic mammal’s wound healing models. In these models, the skin wounds’ microenvironment is expected close to diabetic foot, suffering in hyperglycemic and inflammatory status. The results are clearly presented, with the immunomodulatory effects from mushroom β-glucan and triterpenes that involved in modulating the cell-mediated immune system to cause cellular proliferation and further to introduce healing performance of the chronic inflammation wounds.
Part of the book: The Eye and Foot in Diabetes
Part of the book: Animal Welfare