\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6373",leadTitle:null,fullTitle:"Myocardial Infarction",title:"Myocardial Infarction",subtitle:null,reviewType:"peer-reviewed",abstract:"Atherosclerotic cardiovascular disease is still the most common cause of death among adults. Its prevalence is increasing in developing countries and despite all advances in both diagnostic tools and treatment modalities, it is still very common in the developed world. Obesity, diabetes mellitus, hypercholesterolemia and overuse of dietary salt play a pivotal role in increased cardiovascular morbidity and mortality worldwide. Current clinical efforts are mainly focused on the diagnosis and treatment of myocardial infarction. In this book, we provide epidemiological data on myocardial infarction and atherosclerotic cardiovascular disease, current diagnostic biochemical tests and management strategies. A specific patient group, children, experiencing myocardial infarction are also addressed. Current advances in the management of myocardial infarction have decreased the morbidity and mortality from atherosclerotic cardiovascular disease and especially myocardial infarction; however, more can be achieved by the prevention of atherosclerotic processes via focusing on the early stages of the disease.",isbn:"978-1-78984-869-4",printIsbn:"978-1-78984-868-7",pdfIsbn:"978-1-83881-437-3",doi:"10.5772/intechopen.69907",price:119,priceEur:129,priceUsd:155,slug:"myocardial-infarction",numberOfPages:138,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"10bca0bf18d68ec3c1641dbc3a1ae899",bookSignature:"Burak Pamukçu",publishedDate:"January 3rd 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6373.jpg",numberOfDownloads:12543,numberOfWosCitations:23,numberOfCrossrefCitations:15,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:29,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:67,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 30th 2017",dateEndSecondStepPublish:"June 20th 2017",dateEndThirdStepPublish:"October 29th 2017",dateEndFourthStepPublish:"December 29th 2017",dateEndFifthStepPublish:"February 28th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"70686",title:"Dr.",name:"Burak",middleName:null,surname:"Pamukçu",slug:"burak-pamukcu",fullName:"Burak Pamukçu",profilePictureURL:"https://mts.intechopen.com/storage/users/70686/images/system/70686.jpeg",biography:"Burak Pamukçu (M.D.) obtained a doctorate degree in Cardiology from Istanbul University Faculty of Medicine, Istanbul, Turkey. Dr. Pamukçu finalized his post doctorate fellowship (European Society of Cardiology Atherothrombosis Research Fellowship) at the University Department of Medicine, Centre for Cardiovascular Sciences, City Hospital, Birmingham, England, UK. He is mainly interested in atherothrombosis, atherosclerotic heart vessel disease, antithrombotic therapy and interventional cardiology. Currently Dr. Pamukçu is working as a Consultant Cardiologist and Associate Professor of Cardiology in Acıbadem Healthcare Group. He has published 99 scientific publications and served as reviewer for thirty different medical journals. He is also serving as associate editor and editorial board member at peer reviewed medical scientific journals.",institutionString:"Acibadem Mehmet Ali Aydinlar University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Istanbul University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"170",title:"Cardiology and Cardiovascular Medicine",slug:"cardiology-and-cardiovascular-medicine"}],chapters:[{id:"64090",title:"Introductory Chapter: Atherosclerotic Cardiovascular Disease",doi:"10.5772/intechopen.81697",slug:"introductory-chapter-atherosclerotic-cardiovascular-disease",totalDownloads:963,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Burak Pamukcu",downloadPdfUrl:"/chapter/pdf-download/64090",previewPdfUrl:"/chapter/pdf-preview/64090",authors:[{id:"70686",title:"Dr.",name:"Burak",surname:"Pamukçu",slug:"burak-pamukcu",fullName:"Burak Pamukçu"}],corrections:null},{id:"59778",title:"Epidemiology of Myocardial Infarction",doi:"10.5772/intechopen.74768",slug:"epidemiology-of-myocardial-infarction",totalDownloads:4453,totalCrossrefCites:11,totalDimensionsCites:22,hasAltmetrics:1,abstract:"Coronary heart disease (CHD) is the leading cause of morbidity and mortality throughout the world. The most common form of CHD is the myocardial infarction. It is responsible for over 15% of mortality each year, among the vast majority of people suffering from non-ST-segment elevation myocardial infarction (NSTEMI) than ST-segment elevation myocardial infarction (STEMI). The prevalence of myocardial infarction (MI) is higher in men in all age-specific groups than women. Although the incidence of MI is decreased in the industrialized nations partly because of improved health systems and implementation of effective public health strategies, nevertheless the rates are surging in the developing countries such as South Asia, parts of Latin America, and Eastern Europe. The modifiable risk factors represent over 90% of the risk for acute MI. The risk factors such as dyslipidemia, smoking, psychosocial stressors, diabetes mellitus, hypertension, obesity, alcohol consumption, physical inactivity, and a diet low in fruits and vegetables were strongly associated with acute MI.",signatures:"Joshua Chadwick Jayaraj, Karapet Davatyan, S.S. Subramanian and Jemmi Priya",downloadPdfUrl:"/chapter/pdf-download/59778",previewPdfUrl:"/chapter/pdf-preview/59778",authors:[{id:"223196",title:"Dr.",name:"Joshua",surname:"Chadwick",slug:"joshua-chadwick",fullName:"Joshua Chadwick"},{id:"231054",title:"Dr.",name:"Karapet",surname:"Davatyan",slug:"karapet-davatyan",fullName:"Karapet Davatyan"},{id:"231055",title:"Ms.",name:"Jemmi",surname:"Priya",slug:"jemmi-priya",fullName:"Jemmi Priya"},{id:"244487",title:"Dr.",name:"S.S.",surname:"Subramanian",slug:"s.s.-subramanian",fullName:"S.S. Subramanian"}],corrections:null},{id:"62951",title:"The Diagnostic Value of Biochemical Cardiac Markers in Acute Myocardial Infarction",doi:"10.5772/intechopen.76150",slug:"the-diagnostic-value-of-biochemical-cardiac-markers-in-acute-myocardial-infarction",totalDownloads:2027,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Cardiovascular disease is the leading cause of death worldwide. The role of cardiac markers in the diagnosis, risk stratification, and treatment of patients with chest pain is vital. Patients with elevated cardiac troponin levels but negative CK-MB who were formerly diagnosed with unstable angina or minor myocardial injury are now reclassified as non–ST-segment elevation MI (NSTEMI) even in the absence of diagnostic ECG changes. CK-MB is both a sensitive and specific marker for myocardial infarction. Cardiac troponin T is a cardio-specific, highly sensitive marker for myocardial damage. Cardiac troponin I is a contractile protein exclusively present in the cardiac muscle. The absolute cardiospecificity of cTnI allows the diagnosis of myocardial infarction distinct from muscle lesions and non-cardiac surgery. In 2000, the European Society of Cardiology and the American College of Cardiology redefined AMI with a particular advocacy on troponin. The 2002/2007 American College of Cardiology (ACC) and the American Heart Association (AHA) Guideline Update for the management of these patients strongly recommend to include cTnI. Specifically, with rare exception, the diagnosis cannot be made in the absence of elevated biomarkers of cardiac injury.",signatures:"Shazia Rashid, Arif Malik, Rukhshan Khurshid, Uzma Faryal and\nSumera Qazi",downloadPdfUrl:"/chapter/pdf-download/62951",previewPdfUrl:"/chapter/pdf-preview/62951",authors:[{id:"222194",title:"Associate Prof.",name:"Shazia",surname:"Rashid",slug:"shazia-rashid",fullName:"Shazia Rashid"},{id:"222621",title:"Prof.",name:"Arif",surname:"Malik",slug:"arif-malik",fullName:"Arif Malik"},{id:"238058",title:"Dr.",name:"Rakhshan",surname:"Khurshid",slug:"rakhshan-khurshid",fullName:"Rakhshan Khurshid"},{id:"238060",title:"Dr.",name:"Uzma",surname:"Faryal",slug:"uzma-faryal",fullName:"Uzma Faryal"},{id:"238062",title:"Dr.",name:"Sumera",surname:"Qazi",slug:"sumera-qazi",fullName:"Sumera Qazi"}],corrections:null},{id:"60334",title:"Interventional Therapies for Post-Cardiac Arrest Patients Suffering from Coronary Artery Disease",doi:"10.5772/intechopen.75045",slug:"interventional-therapies-for-post-cardiac-arrest-patients-suffering-from-coronary-artery-disease",totalDownloads:1040,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Acute myocardial infarction and coronary artery disease (CAD) are the most common causes for the development of malignant arrhythmia often leading to cardiogenic shock and cardiac arrest. Structural heart disease represents the main pathology in older patients, whereas young adults mostly suffer from cardiomyopathies and channelopathies. This book chapter delineates modern interventional therapies for patients with cardiogenic shock or aborted cardiac arrest. Epidemiological data on the incidence of malignant arrhythmia depending causing cardiac arrest depending on the presence or absence of CAD and myocardial infarction are presented. Realistic difficulties within clinical decision-making are counterbalanced for and against an early, aggressive and invasive therapeutic approach including early coronary angiography with percutaneous coronary intervention (PCI), targeted temperature management and mechanical cardiac assist devices, depending on the individual clinical presentation and underlying cardiac arrhythmia.",signatures:"Michael Behnes, Philipp Kuche, Ibrahim Akin and Kambis Mashayekhi",downloadPdfUrl:"/chapter/pdf-download/60334",previewPdfUrl:"/chapter/pdf-preview/60334",authors:[{id:"189154",title:"Prof.",name:"Ibrahim",surname:"Akin",slug:"ibrahim-akin",fullName:"Ibrahim Akin"},{id:"204569",title:"Dr.",name:"Michael",surname:"Behnes",slug:"michael-behnes",fullName:"Michael Behnes"},{id:"213288",title:"Dr.",name:"Kambis",surname:"Mashayekhi",slug:"kambis-mashayekhi",fullName:"Kambis Mashayekhi"},{id:"240764",title:"Dr.",name:"Philipp",surname:"Kuche",slug:"philipp-kuche",fullName:"Philipp Kuche"}],corrections:null},{id:"61346",title:"Non-ST Elevation Myocardial Infarction: Diagnosis and Management",doi:"10.5772/intechopen.76241",slug:"non-st-elevation-myocardial-infarction-diagnosis-and-management",totalDownloads:2454,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Cardiovascular disease is expected to be the main cause of death globally due to the rapidly increasing prevalence of obesity, hypertension and diabetes mellitus. Atherosclerotic lesions and plaque rupture are the most common cause of myocardial infarction. Resting 12-lead ECG is the first diagnostic test for patients with chest pain and should be performed and interpreted within the first 10 min of the patient’s admission to the emergency department. Cardiac biomarkers preferably, high-sensitivity cardiac troponin, is mandatory in all patients with suspected NSTEMI for the diagnosis, risk stratification and treatment. Rapid, efficient diagnosis and risk stratification of patients with chest pain will help to administer the appropriate medication and plan for the timing of invasive strategy and the choice of revascularization. This chapter helps to simply but elaborately discuss the diagnosis, risk stratification and the management of patients with non-ST elevation of myocardial infarction.",signatures:"Yaser Al Ahmad and Mohammed T. Ali",downloadPdfUrl:"/chapter/pdf-download/61346",previewPdfUrl:"/chapter/pdf-preview/61346",authors:[{id:"218369",title:"Dr.",name:"Mohammed",surname:"Ali",slug:"mohammed-ali",fullName:"Mohammed Ali"},{id:"248884",title:"Dr.",name:"Yaser",surname:"Alahamd",slug:"yaser-alahamd",fullName:"Yaser Alahamd"}],corrections:null},{id:"60068",title:"Myocardial Infarction in Children",doi:"10.5772/intechopen.74793",slug:"myocardial-infarction-in-children",totalDownloads:1610,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Myocardial infarction (MI) is a clinical condition that develops associated with a sudden reduction or interruption of the blood flow of the vessels supplying the heart for various reasons. The electrocardiographic, echocardiographic and enzymatic diagnostic criteria of MI have been well defined in adults, in children there are some difficulties. Although seen more often in the presence of congenital heart disease (CHD), MI may also be seen in patients without CHD. Unlike atherosclerotic coronary artery disease in adult patients, ischaemia and infarct in children are often associated with coronary artery anomalies and CHD. In addition, congenital prothrombotic diseases, vasculitis, surgical or interventional procedures may also cause ischaemia and infarct. Subendocardial ischaemia, especially aortic stenosis characterised by hypertrophy in the left ventricle is often seen in hypertrophic cardiomyopathy or hypertensive patients. The most important risk factors in neonates and infants are the presence of CHD, coronary artery anomalies and perinatal asfixia. The most frequently seen causes of pediatric myocardial infarction (PMI) are abnormal left coronary artery originating from the pulmonary artery (ALCAPA) and Kawasaki disease. Another often seen cause of PMI is patients who underwent arterial switch operations.",signatures:"Meki Bilici, Mehmet Ture and Hasan Balik",downloadPdfUrl:"/chapter/pdf-download/60068",previewPdfUrl:"/chapter/pdf-preview/60068",authors:[{id:"219534",title:"Associate Prof.",name:"Meki",surname:"Bilici",slug:"meki-bilici",fullName:"Meki Bilici"},{id:"239944",title:"Dr.",name:"Mehmet",surname:"Ture",slug:"mehmet-ture",fullName:"Mehmet Ture"},{id:"239945",title:"Dr.",name:"Hasan",surname:"Balik",slug:"hasan-balik",fullName:"Hasan Balik"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7055",title:"Angiography",subtitle:null,isOpenForSubmission:!1,hash:"20638a6ce5e042484cc33b5b510cdca6",slug:"angiography",bookSignature:"Burak Pamukçu",coverURL:"https://cdn.intechopen.com/books/images_new/7055.jpg",editedByType:"Edited by",editors:[{id:"70686",title:"Dr.",name:"Burak",surname:"Pamukçu",slug:"burak-pamukcu",fullName:"Burak Pamukçu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6209",title:"Endothelial Dysfunction",subtitle:"Old Concepts and New Challenges",isOpenForSubmission:!1,hash:"f6e76bbf7858977527679a6e6ad6a173",slug:"endothelial-dysfunction-old-concepts-and-new-challenges",bookSignature:"Helena Lenasi",coverURL:"https://cdn.intechopen.com/books/images_new/6209.jpg",editedByType:"Edited by",editors:[{id:"68746",title:"Dr.",name:"Helena",surname:"Lenasi",slug:"helena-lenasi",fullName:"Helena Lenasi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7220",title:"Congenital Heart Disease",subtitle:null,isOpenForSubmission:!1,hash:"f59bacfffcccc636ec3082869d10a82e",slug:"congenital-heart-disease",bookSignature:"David C. 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As a result, (1) sectional performance of compressive members, and (2) fast and safe construction method become important. Figure 1(a) shows a conventional concrete-encased steel (CES) composite column using a wide-flange steel section at the center of the cross section. Generally, the wide-flange steel is placed at the center of the cross section, and then longitudinal bars and tie bars are placed in construction site. Thus, the contribution of the steel section to the overall flexural capacity of the column could be limited. Further, the need for rebar and formwork construction requires considerable construction time. Particularly, in mega structures such as semiconductor factory and warehouse using long and large sized columns, fast and safe construction methods are necessary.
\nComparison of CES column and PSRC columns. (a) CES composite column, (b) PSRC composite column (weld connection), (c) PSRC composite column (bolt connection).
In order to improve structural capacity and cost efficiency, a prefabricated steel-reinforced concrete (PSRC) composite column has been used. As shown in Figure 1(b) and (c), the prefabricated steel angles at the four corners replace the conventional wide-flange steel, and the steel angles are weld connected or bolt connected with transverse bars or plates [1, 2, 3, 4, 5]. The weld connection should follow the details prescribed in welding standards [6, 7]. The steel angles resist axial load and flexural moment. The transverse bars and plates provide shear resistance, concrete confinement, and bond resistance between the steel angles and concrete. Because the steel cage of angles and transverse reinforcement are prefabricated off site, field rebar work is unnecessary. Further, the self-erectable steel cage can provide sufficient strength and rigidity to support the construction loads of beams and slabs that are superimposed on the PSRC composite column.
\nFigures 2 and 3 show field application of weld-connected and bolt-connected PSRC composite columns, respectively. Generally, the PSRC composite column with 20 m height and 1.5 m × 1.5 m to 2.0 m × 2.0 m sectional area is used for two- or three-story construction at the same time. In the case of the weld-connected PSRC composite column, the steel cage of angles and transverse reinforcement is moved to construction site, and then concrete form is installed (Figure 2). On the other hand, in the case of the bolt-connected PSRC composite column, concrete form is preattached to the steel cage and it can be permanently used after concrete pouring (Figure 3). Thus, field work related to reinforcing bar placement and concrete form work is excluded, which improves the construction safety and saves the construction time at working in high place.
\nSemiconductor FAB (weld-connected PSRC composite column).
Semiconductor FAB (bolt-connected PSRC composite column).
The prefabricated steel angle composite columns strongly depend on the transverse reinforcement that connects the corner steel angles. The transverse reinforcement provides (1) shear transfer between the steel angles, (2) bond between the steel angles and concrete, (3) buckling resistance for the steel angles, and (4) lateral confinement for the core concrete. To satisfy the requirements of (3) and (4), close spacing as well as sufficient strength are required for the transverse reinforcement. However, the transverse bars welded to steel angles or the transverse plates bolt-connected to steel angles may cause premature tensile fracture of the connection, which should be considered in design.
\nCover concrete provides local buckling resistance and fire resistance for the steel angles. However, when the transverse bars are not closely spaced, the PSRC composite columns are vulnerable to premature spalling of the cover concrete due to smooth surface of steel angles. Particularly, when the columns are subjected to high axial compression force, the load-carrying capacity and deformation capacity of the PSRC composite columns can be degraded by early spalling of the cover concrete. Further, under cyclic lateral loading, the PSRC composite columns are expected to be more susceptible to such damages as the ductility demand increases.
\nThe nominal compressive strengths
where
For better evaluation of the load-carrying capacity of a PSRC composite column, numerical analysis using the stress–strain relationship of confined concrete, unconfined concrete, and steel can be used as shown in Figure 4 [1, 3]. The numerical analysis can be performed using strain compatibility method [9]. The stress–strain relationship of confined and unconfined concrete can be determined from various existing models [10, 11, 12].
\nStress–strain relationships of concrete and steel for numerical analysis.
The nominal compressive strengths
Section analysis methods of PSRC column under eccentric axial loading: (a)
Figure 6 shows the test setup for the concentric axial loading and eccentric axial loading tests. The eccentricity can be controlled using the distance between the column center and loading center. During the test, the load-carrying capacity, axial shortening, and horizontal expansion were measured to evaluate the structural performance of the PSRC composite columns.
\nTest setup of compressive loading tests: (a) concentric axial loading and (b) eccentric axial loading.
Figure 7(a) compares the axial load-strain relationships of a CES and PSRC composite columns using steel ratio of 2.0% under concentric axial compression force [3, 4, 5]. The axial load behavior of the PSRC composite column was similar to that of the CES composite column. The contribution of the steel angles to the lateral confinement increased the peak strength
Axial load-carrying capacities of CES and PSRC columns: (a) concentric axial loading and (b) eccentric axial loading.
Figure 7(b) compares the
The ultimate flexural strength of a PSRC composite column can be evaluated by performing a section analysis based on either plastic stresses (i.e., plastic stress method) or strain-induced stresses (i.e., strain-compatibility method); the stresses of the steel angles, reinforcing bars, and concrete are determined by linear strain distribution and the stress–strain relationships of the materials [1]. Figure 8 shows the stress distributions at the PSRC cross section by two methods. For the plastic stress method (Figure 8(a)), plastic stresses of concrete, steel angles, and reinforcing bars can be used as 0.85
Section analysis methods of PSRC column: (a) plastic stress method and (b) strain-compatibility method.
where \n
The shear resistance of a PSRC composite column is provided by concrete, transverse reinforcement, and steel angles. Since the dimensions of the angle cross section are significantly less than that of the entire cross section, the contribution of the angles to the shear strength is neglected. Thus, the nominal shear strength
where
Figure 9 shows the details of the weld- or bolt-connection between the steel angles and transverse reinforcement. Before spalling of concrete cover, the shear transfer between the steel angles and concrete is provided by friction of the angle surface and concrete bearing of the transverse reinforcement projected from the angle surface. Conservatively neglecting the frictional resistance, the nominal bond strength
where
Bond strength between steel angle and concrete.
Figure 10 shows the test setup for the flexural loading tests to investigate the flexural and shear strengths, shear transfer between steel angle and concrete, and strength at the joint between steel angle and transverse reinforcement. The columns are simply supported, and two-point loading is applied at the center of the columns. To estimate the curvature, deflections at least three points need to be measured.
\nTest setup of flexural loading tests.
Figure 11(a) shows the moment-curvature relationships at the center span of a CES column and a PSRC column with a cross section of 500 mm × 500 mm (i.e., 2.0% steel ratio) [1]. In the PSRC column using the same steel ratio of the CES column, the peak strength was 56.7% greater than that of the CES column for the following reasons: (1) the yield strength of the steel angles used for the PSRC column was 15.9% greater than that of the wide-flange steel section used for the CES column and (2) the angles placed at the four corners of the cross section can develop 35.2% higher nominal flexural capacity than the center wide-flange steel section. In the PSRC column, the load-carrying capacity was suddenly decreased when bond failure (i.e., concrete bearing failure) occurred in the bottom angles in the shear span (Figure 12(b)). After the bond failure, dowel action of the transverse bars developed, causing significant bond-slip deformation. Ultimately, it failed due to the fracture of the transverse bars and spalling of web concrete, which was the typical bond-shear failure mode of the PSRC composite column.
\nMoment-curvature relationships at the center span of CES and PSRC columns: (a) CES and PSRC columns; (b) PSRC columns according to transverse bar spacing.
Failure modes of CES and PSRC columns. (a) CES column, (b) PSRC column, (c) PSRC column @ 100 mm tie, (d) PSRC column @ 200 mm tie, (e) PSRC column @ 300 mm tie.
Figure 11(b) compares the effect of transverse reinforcement spacing on the moment-curvature relationship of PSRC composite columns with a smaller cross section of 400 mm × 400 mm (i.e., 3.1% steel ratio). When the transverse reinforcement at a spacing of 100 mm was used, the load-carrying capacity was degraded due to spalling of cover concrete in the uniform moment span, but was slightly recovered due to the strain hardening of the steel angles. Ultimately, it failed due to the tensile fracture of the bottom angle in the uniform moment span (Figure 12(c)). The moment-curvature relationship and failure mode of the PSRC composite column with greater transverse reinforcement spacing of 200 mm were similar to those of the PSRC composite column with transverse reinforcement spacing of 100 mm. It failed due to tensile fracture of the angles in the uniform moment span (Figure 12(d)). In the PSRC composite column with the greatest transverse reinforcement spacing of 300 mm, bond failure occurred in the bottom angles. After the bond failure, the load-carrying capacity was significantly decreased due to spalling of web concrete caused by dowel action of the transverse reinforcement. Ultimately, it failed due to fracture of the transverse reinforcement (Figure 12(e)).
\nFigure 13 shows the test setup of cyclic loading tests for CES and PSRC composite columns. Using two oil jacks, a uniform axial load corresponding to about 22% of compressive capacity are applied, and a cyclic lateral load is applied using an actuator to the column.
\nTest setup of cyclic loading tests.
Figure 14 compares the cyclic behaviors of the CES and PSRC composite columns using steel ratio of 2.2%. In the CES composite column, the load-carrying capacity gradually decreased after the peak strength. Although spalling of the cover concrete occurred at the lateral drift of 3.0–4.0% in the plastic hinge region, the load-carrying capacity was not significantly decreased. However, after the spalling of the cover concrete, post-yield buckling occurred in the longitudinal bars. Ultimately, it failed at the drift ratio of 7.0% because of a low cycle fatigue fracture of the longitudinal bars. In the PSRC composite column, the peak strength was 20% greater than that of the CES composite column because of the higher yield strength and the location of the steel angles. Spalling of the cover concrete occurred at the drift ratio of 3.0%, and significant shear cracks occurred in the plastic hinge region because of the increased shear demand. The angles and transverse reinforcement were exposed because of the spalling of cover concrete at the drift ratio of 5.0%. The exposed angles and longitudinal bars were subjected to local buckling during repeated cyclic loading. As a result, the load-carrying capacity was degraded. However, despite the local buckling of angles and longitudinal bars, tensile fracture did not occur at the joint between the angles and transverse reinforcement.
\nLateral load-drift relationships of CES and PSRC columns: (a) CES column and (b) PSRC column.
Figure 15 shows a U-shaped composite beam-PSRC composite column connection. In order to minimize the workability problem during concrete pouring, only the web plate of the U-section is passed through the joint, and the top and bottom flanges are connected to the top and bottom band plates in the joint. Under high axial compressive force and cyclic lateral loading, premature cover concrete spalling of the joint may deteriorate the connection’s strength and deformation capacity.
\nBeam-column joint details: (a) interior beam-column joint and (b) exterior beam-column joint.
Figure 16 shows the three mechanisms that contribute to the joint shear strength: web shear yielding of the U-shaped steel section (Figure 16(a)), direct strut action of the in-filled concrete inside the U-shaped section (Figure 16(b)), and the strut-and-tie action between the concrete (outside of the U-shaped section) and the band plates (Figure 16(c)) [2]. The shear strength
where
Joint shear strength mechanisms. (a) Web shear yielding (
The shear strength
where
The shear strength
where
For the strut-and-tie mechanism in Eq. (14), the tension force caused by the concrete strut should be resisted by the top and bottom band plates. Thus, the required cross-sectional area
where 2
The joint shear capacity and demand can be expressed as moments, from the static moment equilibrium at the joint (Figure 16(e)).
\nwhere (Σ
Figure 17 shows the cyclic lateral load-story drift ratio relationships of U-shaped steel composite beam-PSRC composite column joints. The composite beam has 330 mm width and 700 mm height including slab. The PSRC composite column has 800 mm × 800 mm cross-sectional area. In the interior beam-column joint, cover concrete spalling in the PSRC composite column occurred in the vicinity of the U-section, whose web plate buckled, and severe diagonal cracking occurred in the joint face. The fracture was initiated at the weld joint between the web and the bottom flange and then propagated vertically. Because the band plates were not connected to the bottom flange of the U-section, the band plates were not damaged even after cover concrete spalling. However, a gap occurred between the end of the U-section and the column face under positive moments, which was attributed to an anchorage slip of the web plates showing plastic strains inside the joint. As the anchorage slip increased, development of the beam’s flexural capacities was delayed, which caused significant pinching in the cyclic behavior. The top band plates welded to the top flange of the U-section were pulled out under a negative moment. In the exterior beam-column joint, after the peak strengths, the load-carrying capacity was significantly degraded because of cover concrete spalling in the PSRC composite column and because of local buckling and fracture of the web in the composite beam. The steel angles of the column were completely exposed.
\nLateral load-drift relationships: (a) interior beam-column joint and (b) exterior beam-column joint.
In this chapter, a prefabricated steel-reinforced concrete (PSRC) composite column using steel angles was introduced. Using current design codes, the structural capacities of PSRC composite columns can be evaluated, and it shows better performance than those of a conventional concrete-encased steel (CES) composite column.
The axial load-carrying capacity and deformation capacity of PSRC composite columns are comparable to, or even better than, those of conventional CES composite columns. In the PSRC composite column under axial compression, the corner angles and the transverse reinforcement provide adequate lateral confinement to the concrete.
The corner angles of the PSRC composite column increase the flexural strength and stiffness up to about 30%, compared to those of the conventional CES composite columns.
The bond strength between steel angles and concrete is generated by the bearing strength of the transverse reinforcement projected from the steel angle surface. When the bond strength is greater than the demand (i.e., when close spacing of tie bars is used), the PSRC composite columns show ductile behavior after flexural yielding without bond failure, and ultimately fail due to fracture of the steel angles. Otherwise, significant bond slip occurs in the steel angles, and ultimately the columns fail due to the bond failure of steel angles or the fracture of transverse bars.
Under cyclic lateral loading, the PSRC composite columns show about 20% lower deformation capacities than that of the conventional CES composite column. The lower deformation capacity of the PSRC composite columns is attributed to the following reasons: (1) relatively large plastic strains occur in the corner steel angles; (2) after spalling of the cover concrete, the exposed steel angles are susceptible to local buckling; and (3) the shear demand of the transverse reinforcement increases.
In composite beam-PSRC composite column joints, the load-carrying capacity decreases because of the web local buckling of the U-section at the column face. Ultimately, the beam-column joints fail because of a tensile fracture of the buckled web plates initiated at the weld joint between the web and the bottom flange of the U-section. As yielding occurs in the web plate of the beam, significant web plate anchorage slip occurs inside the joint. However, the anchorage slip mitigates possible stress concentration that may be caused by the discontinuity of the flange plate, which contributes to the increase in deformation capacity.
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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. 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Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. His research interests include biochemistry, oxidative stress, reactive species, antioxidants, lipid peroxidation, inflammation, reproductive hormones, phenolic compounds, female infertility.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. 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