Marieta Costache

By Georgescu Sergiu Emil and Costache Marieta

Part of the book: Analysis of Genetic Variation in Animals

By Marieta Costache, Andreea Dudu and Sergiu Emil Georgescu

Part of the book: Analysis of Genetic Variation in Animals

By Andreea Dudu, Sergiu Emil Georgescu and Marieta Costache

Part of the book: Molecular Approaches to Genetic Diversity

By Anca Hermenean, Sorina Dinescu, Mariana Ionita and Marieta Costache

Currently, there are several tissue engineering strategies meant to overcome the incomplete or insufficient bone regeneration conditions offered by autologous bone graft or surgery approaches. In the last decade, attention has been focused toward finding the equilibrium between a suitable scaffold with osteoinductive properties, a cell source with evident potential to develop bone tissue and the appropriate pro-osteogenic factors to condition the differentiation process after cell-scaffold implantation. Consequently, this chapter aims to discuss the benefits that graphene and its derivatives, graphene oxide (GO), bring both to the scaffold biomaterial and to the interaction between the material and the cellular component in order to create a favorable micro-environment for efficient osteogenic differentiation process. Several advantages of including GO in the composition of the materials are shown in relation to cell viability, proliferation, attachment, and osteogenic differentiation.

Part of the book: Advanced Techniques in Bone Regeneration

By Sorina Dinescu, Anca Hermenean and Marieta Costache

Human adipose-derived stem cells (hASCs) currently represent a viable source of mesenchymal-like stem cells, with similar properties and differentiation potential to bone-marrow-derived mesenchymal stem cells (BM-MSCs) but with a different and more accessible source—the adipose tissue. hASCs are able to produce almost all of the factors that contribute to normal wound healing, and therefore, they are preferred for all types of tissue engineering (TE) and regenerative medical applications. This chapter will review hASCs regeneration potential and the most modern approaches in TE for bone, cartilage and adipose tissue regeneration using hASCs. Furthermore, an overview of novel and original hASCs-scaffold constructs studied in our group completes an up-to-date presentation of hASCs multiple uses. Additionally, this chapter will highlight the relevance of ultimate advances in regenerative medicine and the need for this evolution to increase the quality of life in patients with tissue defects.

Part of the book: Stem Cells in Clinical Practice and Tissue Engineering