IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\n
Feel free to share this news on social media and help us mark this memorable moment!
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\n
Feel free to share this news on social media and help us mark this memorable moment!
\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"1403",leadTitle:null,fullTitle:"Advances in Telemedicine: Applications in Various Medical Disciplines and Geographical Regions",title:"Advances in Telemedicine",subtitle:"Applications in Various Medical Disciplines and Geographical Regions",reviewType:"peer-reviewed",abstract:'Innovative developments in information and communication technologies (ICT) irrevocably change our lives and enable new possibilities for society. Telemedicine, which can be defined as novel ICT-enabled medical services that help to overcome classical barriers in space and time, definitely profits from this trend. Through Telemedicine patients can access medical expertise that may not be available at the patient\'s site. Telemedicine services can range from simply sending a fax message to a colleague to the use of broadband networks with multimodal video- and data streaming for second opinioning as well as medical telepresence. Telemedicine is more and more evolving into a multidisciplinary approach. This book project "Advances in Telemedicine" has been conceived to reflect this broad view and therefore has been split into two volumes, each covering specific themes: Volume 1: Technologies, Enabling Factors and Scenarios; Volume 2: Applications in Various Medical Disciplines and Geographical Regions. The current Volume 2 is structured into the following thematic sections: Cardiovascular Applications; Applications for Diabetes, Pregnancy and Prenatal Medicine; Further Selected Medical Applications; Regional Applications.',isbn:null,printIsbn:"978-953-307-161-9",pdfIsbn:"978-953-51-6425-8",doi:"10.5772/1863",price:139,priceEur:155,priceUsd:179,slug:"advances-in-telemedicine-applications-in-various-medical-disciplines-and-geographical-regions",numberOfPages:312,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a8e4b1e59964db023e14fe11b26a232d",bookSignature:"Georgi Graschew and Theo A. 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Following his research studies at the Department for Mathematics and Natural Sciences of the Technical University Dresden (Germany) he gained his Ph.D. there in 1974. After research appointments at various international sites he became in 1987 co-founder of the Research Unit OP 2000 at the German Cancer Research Center DKFZ in Heidelberg (Germany), where he acted as its Scientific Coordinator until its transfer to Berlin. He made major contribution to numerous leading national and international telemedicine projects: SICONET, PANORAMA, GALENOS, DELTASS, MEDASHIP, EMISPHER. He has co-authored more than 360 scientific publications and presentations and holds 18 patents in Germany, the European Union, Japan and USA.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Charité",institutionURL:null,country:{name:"Germany"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"19129",title:"Dr.",name:"Theo A.",middleName:null,surname:"Roelofs",slug:"theo-a.-roelofs",fullName:"Theo A. Roelofs",profilePictureURL:"https://mts.intechopen.com/storage/users/19129/images/1575_n.jpg",biography:"Dr. Theo A. Roelofs has been working since 1999 as Research Associate & Project Manager at the Surgical Research Unit OP 2000 of the Max-Delbrück-Center for Molecular Medicine and the Experimental and Clinical Research Center of Charité – University Medicine Berlin (Germany). He also contributed to various international Telemedicine projects (GALENOS, DELTASS, MEDASHIP) and acted as manager of the EMISPHER project. Following his studies in Molecular Sciences at the Wageningen University (Netherlands) and his Ph.D. in Biophysics (Max-Planck-Institute for Radiation Chemistry, Germany, and Free University at Amsterdam, Netherlands) he was a visiting research associate at the Chemical Biodynamics Department of the Lawrence Berkeley National Laboratory (USA, 1992-1994) and a research & education associate at the Physics Department of the Free University at Berlin (DE, 1994-1999). 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\r\n\tThe book also welcome chapters that provide a comprehensive overview about corals zoology, encompassing Taxonomy, Systematic and evolution using morphologic and/or molecular approaches; corals ecology, including population structure and dynamic, associated biodiversity and models of distribution; mapping and characterization of coral habitats, including suggestions for proper conservation measures; anthropogenic impacts affecting corals at different latitudinal and bathymetric ranges, with particular attention to the fishery, pollution and climate changes; corals adaptations to a rapidly-changing environment, with insight on the still poorly-known physiology, acclimation strategies and resilience; direct or indirect interactions between corals and humans, with examples of a possible coexistence between sustainable economic and social activities (e.g. tourism) with healthy coral habitats. All these topics are likely to add few more tiles to the still-incomplete mosaic of knowledge about corals from tropical to polar latitudes, from shallow reefs to the unseen depths of the ocean.
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1. Introduction
Due to industrialization and improved living standards, global energy consumption is on the rise. Simultaneous population growth and per capita energy demand led to increased fossil fuel production and consumption accounting for about 80% of world energy consumption, while nuclear, biomass, and hydroelectric energy accounting for the remaining 20%. This trend of fossil fuel use as the largest portion of the growing global energy mix results in a steady increase in CO2, NO2 and SO2 emissions, leading to environmental threats. Therefore, seeking sustainable solutions is urgent. Biomass is defined as biological and carbon-containing material derived from living or recently living organisms. Biomass is one of the biggest sources of energy and is a renewable, possibly efficient, and an attractive alternative to fossil fuels. Biomass when compared to fossil fuels contains much less carbon, more oxygen, and less heat in the range of 12–16 MJ/kg [1]. Its average net greenhouse gas emissions are lower than fossil fuels, an environmental advantage that may be a key driver for biomass and waste energy extraction. Biomass is the predominant source of energy in many developing countries, but in some industrialized ones it also plays an important role. Biomass-based options for energy production are widely researched and developed to replace fossil fuels in heat and electricity production, chemicals formation, agriculture, moving towards sustainability, regional economic and social development in order to alleviate the emission of greenhouse gas [2].
1.1 General overview: thermochemical biomass conversion methods
Through biochemical, chemical, and thermochemical conversion techniques, the chemical energy that is contained in biomass is converted to heat, electricity or fuel. Biochemical and chemical methods can only convert selected biomass to biogas, biodiesel, etc., while most biomass materials can be thermochemically converted. Thermochemical biomass conversion is one of the most energy-efficient, flexible, and high-energy yield methods for extraction of energy from biomass and organic waste, and therefore one of the most promising pathways with many environmental benefits. This thermal treatment can be divided into different processes depending on the supply of oxygen: (1) combustion; direct biomass burning using excess oxygen, (2) gasification; biomass burning with a limited oxygen supply, and (3) pyrolysis; biomass burning without oxygen [3], where gasification is the most efficient energy extraction process [4, 5].
Given its economic and environmental benefits, gasification has attracted worldwide attention. Many agricultural and industrial waste streams that are currently problematic can be used sustainably through gasification. Industrial waste (e.g., from the food and pulp and wood industries), municipal waste (e.g., household waste), or agricultural waste (e.g., gardening and animal manure) [6] and energy products can be all converted into a mixture of non-combustible gas in a gasifier (producer gas) via gasification. Gasification is the conversion of solid carbon to a gas under a limited oxygen supply at high temperatures (400–1000°C [7]). Producer gas is a mixture of CO, H2, CH4, slight amounts of other light hydrocarbons, steam, CO2, N2, in addition to impurities like char, ash, tar, and oil particles. The producer gas can simply be stored and combusted at a later time to produce heat and/or steam. The producer gas can also produce electricity when used in gas turbines or to power and engine-generator combo. Syngas is the purified producer gas that can be used as fuel or as feedstock to produce higher value fuel or chemicals [8].
Although the main feedstock for gasification can be any hydrocarbons; the acceptable range of feedstock properties is practically very narrow for most existing real world gasifiers. This is a major disadvantage compared to incineration. The reaction chemistry and fluid-dynamics within gasifiers tend to be highly sensitive to changes in the composition of raw materials, their reactivity, density, particle size, moisture, and ash content. The beneficial output in combustion plants is power and possibly heat, while the output in gasification can also be chemicals, liquid fuels or hydrogen in addition to power and heat. Due to the presence of acid gases, tar particles, and other impurities that exist in the gas produced by the gasifier, the producer gas should be treated properly for optimal production of chemicals, liquid or hydrogen fuels and internally-fired cycles (internal combustion engines, gas turbines) [8].
Biomass conversion efficiency varies based on the gasifier itself, purpose of use, type of treated material, its particle shape and size, and the gas flow. The process of gasification which occurs in gasifiers can be divided into five groups: (1) the calorific heat of the producer gas is high when it is between 10 to 40 MJ/Nm3; it is medium if it is between 5 to 10 MJ/Nm3; and it is low when below 5 MJ/Nm3; (2) nature of gasification agents (air, O2, steam, H2); (3) the direction in which consuming material and gasifying agents move (updraft, downdraft; cross draft or fluidized bed); (4) operating pressure (atmospheric or high pressures of up to 6 MPa); (5) type of feedstock (municipal solid waste (MSW), industrial waste, biomass/wood). There are only a few processes that do not fall into these categories, namely molten iron bath gasification, in situ gasification (underground gasification), plasma gasification or hydrogasification and rotary kiln gasification [8, 9].
1.2 Gasification vs. combustion
Combustion has been a viable method for waste management with drawbacks such as harmful process residues and hazardous emissions. Gasification has come up to tackle these issues and improve energy efficiency. Gasification reduces corrosion and emission by preserving alkali and heavy metals (excluding Hg and Cd), sulfur and chlorine in the process residues, greatly inhibiting dibenzo-p-dioxins (PCDDs) and chlorinated dibenzofluorans (PCDFs) formation and decrease the formation of thermal nitrogen oxides (NOx) owing to lower temperatures and reducing conditions [10]. Slag gasification can destruct dangerous compounds, however, S and Cl species such as H2S and HCl might remain present in the producer gas. When producer gas volume is small, lower dimensioned gas cleanups is needed. This can save the cost of investment while using O2 raises both the costs and the producer gas calorific value. Producer gas can be used in different applications energetically or as raw material which has a higher efficiency [9, 11]. Some of the potential benefits of gasification versus combustion and their corresponding potential drawbacks are summarized in Figure 1, using reference [12] with the permission of Elsevier.
Figure 1.
Comparison of waste gasification and combustion.
PCDD/Fs are a group of unwanted by-products and pollutants coming from thermal and combustion processes. The toxicological and chemical properties of compounds of this sort depend on the number and position of the chlorine atoms that are bound to the two aromatic rings [13]. PCDDs and PCDFs are composed of 75 and 135 homologs, respectively. Specific isomers of PCDD/F have been recognized for their toxicological properties that have serious carcinogens [14]. They are highly toxic and cause severe bronchitis, asthma, and strangulation of the lungs in humans. Agricultural lands and livestock in the vicinity of incinerators can also be affected by dioxin that infects meat, dairy products, and so on. Consuming these products may destroy the human immune system, thyroid function, hormone dysfunction, and causes cancer. It has negative health condition in infants because of dioxin exposure through breast milk and uterine exposure. Scientists have conducted numerous experimental studies on experimental animals (rats and mice) to investigate the effects of dioxin contamination that lead to carcinogenicity, liver toxicity, and immune toxicity. 2,3,7,8,8-tetrachlorodibenzo-p-dioxin (TCDD), considered to be very toxic and assigned a toxic equivalence factor (TEF) value of 1 [10, 15, 16], and commonly used as a test substance in toxicity tests. In immunotoxicity experiments, 2,3,7,8-TCDD caused thyroid atrophy, cellular and humoral immune abnormalities, constrained host resistance to viral infections, and inhibited antibody formation [17].
In 1977, the release of PCDD/F from incineration processes was first observed. Since then, researchers have evaluated emission of this compound by a series of thermal processes that include integrated combustion and gasification [16]. The main reason for the negative environmental reputation of waste incineration is the emission of PCDD/F and other pollutants during the process [18], especially for MSW incineration [19, 20, 21]. After PCDD/F enters the atmosphere, they are exposed to chemical, physical, and biological changes and eventually contaminate soil, body and sediment [22].
The purpose of this chapter is to shed more light on PCDD/F formation and their sources in combustion. The main objective is to review the PCDD/F formation in gasification as there is no review on formation and emission of dioxins from processes based on gasification know-hows. This chapter highlights the likelihood of reducing the emission of PCDD/Fs to well below regulatory limits or even detection limits, by using gasification technology. We have done a thorough study of all the accessible articles came into existence over the last 30 years in literature to be able to frame this review which is really felt missing in the field.
2. Dioxin formation
In the 1950s and 1960s, incinerating organic waste from chemical plants and releasing greenhouse gases into the atmosphere became common practice. Its extension to incineration of solid waste, especially MSW, increased during the 1960s and 1970s and enabled these processes to recover the energy generated by waste incineration, reduce the waste by 80–90% of volume, and consequently decrease the areas required for landfilling. Nonetheless, the release of very toxic organic compounds from waste incineration, recognized as dioxins, was not known back then [23]. Actually, the toxic effects of PCDD/F were not materialized until around the end of 1980s. Due to maximum enforcement of available control technology regulations, the release of “toxic equivalent” dioxin (TEQ) from US power plants was lessened by three orders of magnitude to less than 12 g of TEQ per year by 1987 [24]. It has been widely acknowledged that combustion processes lead to the formation or emission of by-products such as NOx, SOx, HCl, TOC, CO, HF, and CO2 into the atmosphere. Moreover, small quantities of toxic substances such as metals and PCDD/F are released into the atmosphere [23]. Figure 2 shows the structure of PCDD/Fs [25].
Figure 2.
Molecular structure of polychlorinated dibenzo- p-dioxins (a) and dibenzofurans (b). Reprinted from [25] with the permission of Elsevier.
2.1 Dioxin formation during combustion
The formation and emission of dioxin - group of chlorinated poly-nuclear aromatic compounds - from waste combustion is of prodigious public concern. Dioxin is released in small quantities from combustion sources mainly in the process of municipal waste incineration, which is one of the most important sources of PCDD/Fs formation in the environment. Therefore, dioxin control measurement from combustion sources has become vital and the mechanisms of dioxin formation have been comprehensively investigated because of its carcinogenic and mutagenic effects.
2.1.1 Mechanism of PCDD/F formation
PCDD/Fs can be formed when reaction of hydrocarbons and chlorine takes place in vicinity of O2 and metals like Cu at high temperatures of 200 to 800°C. There are many theories regarding the mechanism of dioxin formation. PCDD/F formation proceed via: (1) homogeneous (gas phase) reactions at high temperatures (500 to 800°C), and the main mechanism of the reaction process is via chlorination precursors like chlorophenol (CP) and chlorobenzene (CB) in the gas phase. This high-temperature homogeneous path is known as “precursor route” in which a smaller subset of PCDD/Fs is formed in the gas phase. (2) heterogeneous (surface-catalyzed) reactions at lower temperatures (200 to 400°C) in the post-combustion zone [21, 26]. This low temperature heterogeneous path is called the “de novo route” (for the PCDD/Fs subset of carbon, oxygen, hydrogen and chlorine in the cooling flue gas). In the heterogeneous mechanism, the formed PCDD/Fs may also come from CPs or CBs or from carbon in fly ash. The catalytic effect of fly ash or soot is the main factor in the latter case, and this is a well-known example of a de novo process. It is said that the two pathways of dioxin formation occur simultaneously and independently. It is still debated whether the carbon in the heterogeneous PCDD/F mainly comes from gas precursors or from carbon in fly ash [25, 27]. Dickson et al. [28] disclosed that under similar conditions, the rate of PCDD/Fs precursor formation is 72–99000 times higher than the rate of carbon formation in fly ash. Luijk et al. [29] thought that the formation of PCDD/Fs from precursors was about 3,000 times faster than the de novo process of activated carbon. The precursors were found to be the major source of PCDD/Fs formation by Tuppurainen et al. [30]. Figure 3 is a stylized illustration of the mechanisms by which PCDD/F is formed in combustion systems. The surface shows a particle of ash, and the arrows depict both the reaction and absorption processes. Thick arrows indicate the relative importance of pathways in the formation of PCDD/F.
Figure 3.
The pathway for formation of PCDD/F is illustrated in this diagram. Reprinted from [25] with the permission of Elsevier.
The emission of PCDD/Fs is directly related to the amount of carbon used. Along with CP, CBs, polycyclic aromatic hydrocarbons (PAHs), and residual carbon, there are also key elements that influence the formation of PCDD/Fs including residence time, precursors, combustion temperature, PCDD and chlorine in the feed, feed processing, supplemental fuel and oxygen availability [31, 32].
Dioxin formation happens in a temperature range of 200 to 800°C with a maximum reaction rate reached between 350 to 400°C [33]. Data from the literature show that the rate is very slow in the range of 200 to 250°C. Under optimum combustion conditions (such as adequate oxygen, mixing, and airflow), virtually all organic compounds including PCDD/F are destroyed above 800°C. However, PCDD/F is formable at high temperatures, but under less optimum conditions like insufficient oxygen [34]. Dioxin formation correlates well with access to organic precursors, CO, unburned carbon or combustion products (even soot particles), metal salts and hydrogen chloride/chlorine. Dioxins are formed during the cooling cycles of the flue gas in combustion systems. This formation process goes via one of the two mechanisms mentioned above [21, 35]. The main mechanism of dioxin formation in combustion systems appears to be de novo synthesis where morphology of the carbon from deteriorated graphical configuration is critical for dioxin formation. Therefore, such carbon morphologies have been investigated. It was found that the soot particles from gas phase combustion reactions including deteriorated graphical configurations are a potential source of de novo dioxins synthesis.
The formation of PCDD/F in combustion processes can be described in a two-step route: (1) formation of carbon: carbon particles comprised of deteriorated graphical configurations in the combustion region. (2) oxidation of carbon: the carbon particles that have not been properly burnt can still be oxidized in low temperatures after combustion. PCDD/Fs are by-products of oxidative degradation of the graphical structure of carbon particles. There are several steps and chemical reactions involved in these routes. Here are at least three known steps for carbon formation: nucleation, agglomeration and particle growth. Here are four steps involved in carbon oxidation: oxidant adsorption, complex intermediate formation with metal ion catalysts, interaction with graphitic carbon structure, and product desorption. The nature of these chemical reactions is complex and heterogeneous [21].
Since the reactants for the formation of PCDD/Fs are inadequate during combustion, the combustion conditions are likely to have a major influence on the formation of PCDD/F. There are some conditions in the combustion process that can cause a favorable formation of PCDD/F. These conditions are: low combustion temperature, poor turbulence in the combustion chamber, short residence time in the combustion zone, low O2 content resulting in deficient combustion, sluggish flue gas cooling process in the critical temperature range [23]. Moreover, existence of metals (Cu, Fe, Pb and Zn) [35] in fly ash catalytically increase formation of PCDD/F. Also in presence of these metals, PCDD/F can react with chloride and unburned carbon and contribute to the so-called de novo synthesis of PCDD/F [35, 36, 37].
Chlorine content in raw materials is one reason for PCDD/Fs formation during combustion [21, 38]. When combusting wood, for example, presence of phenol, lignin or carbon and chlorine particles can contribute to emission of PCDD/Fs [39]. Since the concentration of chlorine in uncoated natural wood is low [40], the combustion of this feedstock yields a much lower emission rate of PCDD/Fs compared to when combusting straw, coal, and sewage sludge [41]. Contrarily, during combustion of wood, PCDD/Fs compounds can remain on the surface and thus be removed by fly ash particles. Thus, primary and secondary emission control measurements are vital to effectively mitigate this part of the PCDD/FS emission in the flue gas. Some example of these control measurements are: usage of high quality wood fuel, optimizing combustion conditions, and try to precipitate the fly ash at low temperatures (less than 200°C) [42].
There is a review on dioxin emission from wood combustion by Lavric et al. [19] emphasizing on the fact that the combustion conditions and fuel properties are the most dominant considerations on the dioxin release rate. They concluded that using flue gas cleaning systems when combusting non-contaminated natural wood, lowers the level of dioxin emission below the legitimate levels. The minimum concentration of dioxin in greenhouse gas emissions prescribed by most current European legislation is 0.1 ng m3 expressed in I-TEQ units [43].
2.2 Dioxin formation in gasification
The formation of harmful chemicals, especially PCDD/Fs, is the most serious problem. It is important to reduce the formation of polychlorinated compounds and increase their capture due to their environmental emissions. Although there is an increasing trend of well-designed gasifiers with a broad range of raw materials that are essentially used in gasifiers, not all materials should necessarily be gasified in a given setup. Processed plastic, rubber, and tanned leather [44] as well as various animal biomasses (such as food waste) and sewage sludge [45] contain large amounts of chlorine.
Solid waste segment is commonly treated at incinerators. Energy generation via waste incineration has become an effective way of managing combustible waste, because it reduces the volume and mass of waste. Nevertheless, perilous emissions and detrimental process residues are among the drawbacks of incineration. Incineration causes fly and bottom ashes, and thus release leachable toxic heavy metals, PCDD/Fs, and volatile organic compounds. Therefore, it is possible to replace incinerators with gasifiers. Incinerators emit PCDD/Fs and their concentration often exceeds the legal limit, which calls for a different technology for waste treatment. Gasification processes usually emit PCDD/Fs within acceptable limits as determined by national and international organizations [35]. The amount of pollutants in producer gas can be lower than that of the flue gas of an incinerator [46], and it is because of partial oxidation of waste with limited oxygen supply [47]. Gasification benefits from numerous advantages in comparison of traditional waste combustion. It occurs in a low oxygen environment (where the equivalence ratio varies between 0.25 to 0.50) which limits the formation of PCDD/Fs and large amounts of SOx and NOx [48]. Gasification reduces the emission of acidic gases due to higher temperatures and reduction conditions [49]. However, small amounts of PCDD/Fs can result from deficient destruction of the PCDD/Fs present in the waste itself or from the existence of organic chlorinated compounds in the reactor [50, 51].
It is evident that the mechanisms of dioxin formation and its related amounts to producer gas correlate well with tar formation, and is therefore a relatively comparable parameter for all gasifiers in which tar is partly converted to producer gas [52]. Zwart et al. scrutinized the formation of dioxin from refuse derived fuel (RDF), sewage sludge, and untreated wood pellets gasification in an extensive range of temperatures. The outcome revealed that the level of dioxins was very different in terms of gasification temperature and feedstock quality (chlorine content). Their conclusion was that high amounts of chlorine in the feedstock cause dioxin formation, especially at temperatures below 800°C. At temperatures above 800°C, dioxins levels are drastically reduced, along with corresponding tar levels. At temperatures above 850°C, the PCDD/Fs concentration in the producer gas was within the range of 0.5 ng TEQ/Nm3 for clean wood pellets and sewage sludge. However, PCDD/Fs concentrations became lower in higher temperatures for RDF, it was still above the allowed limit [52].
3. PCDD/Fs removal
Assessing the environmental impacts of gasification know-how is vital to ensure the practicality of the process. An occasional misconception that gasification plants are only minor variations of incinerators is the cause of gasification processes to still face environmental community resistance. One important distinction is that gasification can be an intermediary process for the production of producer gas in a broad range of applications. Utilizing syngas to generate on-site electrical and thermal energy is the most dominant process in gasification, however, the production of chemicals and fuel may be the ideal goal for the near future. Gasification contributes to air pollution control and make it less complex and costly compared to that needed for incineration. Although cleaning exhaust gases from non-combustion thermochemical conversion processes could be simpler than that of incineration, proper design and emission control systems are critical to satisfy health and safety requirements. Products of gasifiers must be controlled before discharging into the air as they can comprise several air pollutants. These include particles, hydrocarbons, CO, tars, N2, SOx, and small amounts of PCDD/Fs.
Lonati et al. [53] evaluated the risk of human carcinogenicity owing to the release of PCDD/Fs and Cd from a waste gasification plant using a probabilistic method. Probability density functions were used to define emission rates and risk model parameters of pollutants via Monte Carlo simulations. This gave a probability distribution estimation with involvement of epistemic uncertainty and aleatory variability. The results showed that Cd emissions are much higher than PCDD/Fs despite their higher toxicity. PCDD/Fs concentrations were well below the current permissible limit of 0.1 ngTEQ m3. They indicated that 95% of carcinogenic risk is due to Cd exposure.
To control greenhouse gas emissions from gasification processes different strategies can be adapted, depending on plant configuration, the requirements of specific energy conversion equipment or reactors and catalysts for downstream fuel synthesis. In any case, there is the advantage that it can be possible to control the air pollution of the reactor and the exhaust gas output in numerous cases using a combined method [9]. Coal filters were the first dioxin-reducing technologies, which were installed in the backend of an air pollution control system in many wastes to energy plants, in the late 1980s.
Filters also helped to absorb other organic compounds and mercury, but their bulky volume and probability of ignition were their pitfalls. For the sake of safety, inorganic sorbents such as zeolites were used for monitoring and inertisation of CO [54]. It was also found in the 1980s that oxidative catalysts have high degradation potential for dioxins [55]. Those catalysts were initially operational at 300 to 350°C, and then they were further developed to reach higher destruction efficiency of 99% at temperatures of about 230°C [56].
The high operating temperature (> 1000°C) along with oxygen deficiency eliminates any PCDD/Fs that may be present in the raw material and eradicates potential formation of PCDD/Fs. Thus, operating the gasification process at high temperature or maximizing the conversion of hydrocarbons that are being produced in pyrolysis are possible approaches to reduce the formation of dioxins [57]. For example, high-temperature gasification lowers dioxin formation when high-chlorine content fuels are used [57]. Another effective and easily applicable measure is the rapid cooling of the syngas by a water immersion that inhibits the synthesis of PCDD/Fs [58]. The capture of PCDD/Fs by a special multi-step absorption filter is the most effective method of removing dioxins from the residual burst stage and/or the gas or cooling effluent, regardless of technology used. Volatile organic compounds such as PCDD/F and other organics are effectively eliminated in the gaseous and liquid phases due to the high temperature reactor and shock cooling [35, 59].
As an example, Andersson et al. who got inspired by Griffin’s theory [60] were successful to lower the concentration of dioxins [61]. They increased the concentration of SO2 in the flue gas and adjusted the Cl/S ratio in a way that lowered the concentration of dioxin to around 0.1 ng(TE)/m3 in the raw gas. As another example, Pařízek et al. applied the REMEDIA technology in a MSW incinerator, and they varied the operational temperature from 180–260°C. They saw that the degradation efficiency can be extended to 99–97% while dioxin emission can be lowered below 0.1 ng. (TEQ)/m3 [62]. REMEDIA technology benefits from catalytic substrates that are overlaid on a two-layer polytetrafluoroethylene (PTFE) membraned material to filter and eliminate PCDD/F.
Off-gas cleaning system is vital for both incineration and gasification processes in thermal waste treatment plants, as it keeps the amount of pollutants being released into the environment lower than that legislated. PCDD/F can be cleaned using DeNOx/DeDiox technologies such as sodium bicarbonate or PCDD/F removal using catalytic filtration or adsorption materials such as activated carbon [63].
3.1 Catalytic filtration of PCDD/F
On the basis of applied applications it has been found that the method of dioxin removal by catalytic filtration REMEDIA [64] is highly effective. A GORE-TEX is a special fabric filter bags usually used in catalytic filtration by which particles of solid fly ash are well separated via instantaneous removal of dioxins in flue gases. The filtration efficiency of the gas can be elevated to around 96.6% due to a PTFE-type membrane used in the external filtration layer. This refined gas is then driven inward the internal filtration layer comprised of catalytically active compounds that can eliminate dioxins further to reach 98.8% efficiency. The external filtration layer is periodically revived with the help of a usual pulse jet cleaning system. In the gasification process, catalytic filtration is usually placed immediately after a mechanical cleaning of the flue gases [65].
The Japanese government enforced the guideline of dioxin emission via Waste Management and General Purification Act (WMGPA) in 1997. After this WMGPA enforcement, the industrial sector was obliged to install catalytic reactors and bag filters in the new facilities. Following this enforcement, not only the adjusted values for the combustion temperature, the cooling temperature of the exhaust gas from the furnace, and the CO concentration in the exhaust gas from the stack were satisfactory at almost all facilities, but also the concentration of dioxin, acidic gases, and NOx in the discharged gases was significantly lower than those made before 1997 [66].
3.2 Technology DeNOx/DeDiox
One proficient approach to remove Dioxin is to combine its catalytic degradation with selective reduction of NOx according to the following stoichiometric equations [67]:
NO+4NH3+O2→4N2+6H2OE1
C12HnCl8−nO2+9+0.5nO2→TiO2n−4H2O+12CO2+8−nHClE2
In order to selectively reduce NOx, ammonia can be injected prior to the catalytic reactor. Simultaneous removal of NOx and dioxins (DeNOx/DeDiox) can be carried out in a catalytic reactor at 200 to 300°C [56]. Although the NOx and dioxins removal via this method is a highly efficient process, catalyst poisoning is one of the main detriments. In addition to mechanical and chemical cleaning, the reactor in this setup needs to be installed after dust removal from flue gases (Figure 4). This means that re-heating of the flue gases to 200–300°C is required [68].
Figure 4.
Scheme of DeNOx/DeDiox technology [69].
Parizek et al. [69] analyzed the economical balance of catalytic filtration versus DeNOx/DeDiox technology. They used a computer-based system for simulation calculations making solution more approachable. The annual economic balance of the operation of the catalytic filtration REMEDIA is composed of: cost of the filtration bags (for this study the guaranteed lifespan and real lifespan of the filtration tube was 4 and 8 years, respectively), energy cost of the fan drive, cost required to spray the flue gases before entering the filter. Also the annual economic balance of the operation of DeNOx/DeDiox technology is composed of: catalyst costs (a 4-yar life-time operation was considered), energy costs of the fan drive, and cost for heating of flue gases. Results showed that the operating cost of the DeNOx/DeDiox technology rises due to the reheating of flue gases to the required temperature of the reaction and the cost was linked with the increased pressure drop. Catalytic filtration does not require heating of flue gases and the cost of the filtration bags falls due to their real lifespan.
4. Experimental evidence of PCDD/Fs in gasification and reliable mitigation
In an upcoming article [70] we will publish and extensive review of experimental measurements and evidence of PCDD/F emissions from gasifiers of various types and sizes, varying operating conditions and feedstocks.
The main findings are:
Although PCDD/F emissions from gasification are in general lower than those from incinerators without modern emission control of the same feedstock it is not correct to assume that PCDD/F emission from a gasifier will necessarily be safe or below regulatory limits. PCCD/F can be produced in gasification above safe and regulatory limits.
The two main factors that can widely and reliably reduce PCCD/F emissions to very low levels in gasification are
peak operating temperature (> 1000°C) in the combustion and cracking zone together with oxygen deprivation
rapid cooling of syngas by for example a water quench which prevents de novo synthesis
high amounts of chlorine in the feedstock cause dioxin formation, especially at temperatures below 800°C. At temperatures above 800°C, dioxins levels are drastically reduced.
5. Future work or guidelines
The main purpose of this chapter is to assist researchers in making primed decisions when adopting waste management policies and conducting relevant research and environmental impact studies. There is a need to establish more information on PCCD/F formation in gasification by experimentation of different feedstock when using different operational parameters and removal technologies; in order to be able to choose an appropriate PCCD/F mitigation method when gasifying different waste streams.
6. Conclusions
Dioxin formation and emission from the incineration of waste have been reduced in Europe and North America by either decommissioning plants or otherwise installing of air pollution control systems [71, 72, 73]. However, given the severity of the health impacts and continued unknowns (like emissions during start-up, shut-down and other peak events) the topic continues to be of great public concern both in Europe and North America [73, 74, 75] and the developing world [73, 76, 77]. Gasification can offer a substitute approach for waste treatment and energy generation that may indeed more consistently achieve lower toxic PCDD/F emission levels compared to combustion.
All combustion processes can result in formation of PCDD/F at temperature range of 200 to 600°C in case organic carbon, oxygen, and chlorine become accessible. The formation of dioxins is effectively reduced due to the high temperature reactor (in special cases >1000°C) and shock cooling of gases combined, with an absence of available oxygen.
Acknowledgments
Financial support was provided by the Rannís Technology Development Fund (project 175326-0611), the Icelandic Research Fund (grant 196458-051), and the Northern Periphery and Arctic program (project H-CHP 176).
Conflict of interest
The authors declare no conflict of interest.
Nomenclature
PCDDs
Polychlorinated dibenzo-p-dioxins
PCDFs
Polychlorinated dibenzofurans
TCDD
2,3,7,8-tetrachlorodibenzo-p-dioxin
PCBs
Polychlorinated biphenyls
TEF
Toxic equivalence factor
TEQ
Toxic equivalent
CPs
Chlorophenols
CBs
Chlorobenzenes
PAHs
Polycyclic aromatic hydrocarbons
SOx
Sulfur oxides
NOx
Nitrogen oxides
DeNOx/DeDiox
Removal of nitrogen oxides and dioxins
RDF
Refuse derived fuel
MSW
Municipal solid waste
WEEE
Waste electrical and electronic equipment
PVC
Polyvinyl chloride
BR
Cogasified biofermenting residue
iGCLC
In-situ gasification chemical looping
GEK
Gasifier’s experimenter’s kit
LHV
Low heating value (MJ/m3)
HHV
High heating value (MJ/m3)
\n',keywords:"gasification, dioxins, furans, dioxin formation mechanism, PCDD/F removal technologies",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/74698.pdf",chapterXML:"https://mts.intechopen.com/source/xml/74698.xml",downloadPdfUrl:"/chapter/pdf-download/74698",previewPdfUrl:"/chapter/pdf-preview/74698",totalDownloads:318,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:2,totalAltmetricsMentions:0,introChapter:null,impactScore:1,impactScorePercentile:65,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"October 11th 2020",dateReviewed:"December 12th 2020",datePrePublished:"January 5th 2021",datePublished:"September 29th 2021",dateFinished:"January 5th 2021",readingETA:"0",abstract:"PCDD/Fs are a 75-member family of toxic chemicals that include congeners (members) that have serious health effects including congeners that are classified group 1 carcinogens, endocrine disruptors and weakening or damage to the immune system. Municipal solid waste (MSW) incinerations had historically been implicated as the major source of PCDD/Fs distributed by air. As a result of awareness and legislation most European MSW incinerators were either shut down or equipped with modern air pollution control systems necessary to achieve MSW incineration with PCDD/F emissions within regulatory limits set by national and international laws (typically <0.1 ng TEQ/Nm3). There is a common belief that gasification of waste and/or biomass, unlike incineration, inherently and always achieve emission below regulatory and detectable limits. However, a review of the literature suggests that the belief that the substitution of incineration with gasification would always, or necessarily, reduce PCDD/Fs emissions to acceptable levels is overly simplistic. This chapter discusses the mechanisms of PCDD/Fs formation, the operational measures and parameter ranges that can be controlled during gasification to minimize PCDD/Fs formation, and methods for post-formation PCDD/F removal are reviewed. The purpose of this chapter is to assist researchers and practitioners in formulating waste management policies and strategies, and in conducting relevant research and environmental impact studies.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/74698",risUrl:"/chapter/ris/74698",book:{id:"10036",slug:"gasification"},signatures:"Seyedeh Masoumeh Safavi, Christiaan Richter and Runar Unnthorsson",authors:[{id:"86966",title:"Dr.",name:"Runar",middleName:null,surname:"Unnthorsson",fullName:"Runar Unnthorsson",slug:"runar-unnthorsson",email:"runson@hi.is",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Iceland",institutionURL:null,country:{name:"Iceland"}}},{id:"335243",title:"Ph.D. Student",name:"Seyedeh Masoumeh",middleName:null,surname:"Safavi",fullName:"Seyedeh Masoumeh Safavi",slug:"seyedeh-masoumeh-safavi",email:"sms36@hi.is",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"335534",title:"Prof.",name:"Christiaan",middleName:null,surname:"Richter",fullName:"Christiaan Richter",slug:"christiaan-richter",email:"cpr@hi.is",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Iceland",institutionURL:null,country:{name:"Iceland"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 General overview: thermochemical biomass conversion methods",level:"2"},{id:"sec_2_2",title:"1.2 Gasification vs. combustion",level:"2"},{id:"sec_4",title:"2. Dioxin formation",level:"1"},{id:"sec_4_2",title:"2.1 Dioxin formation during combustion",level:"2"},{id:"sec_4_3",title:"2.1.1 Mechanism of PCDD/F formation",level:"3"},{id:"sec_6_2",title:"2.2 Dioxin formation in gasification",level:"2"},{id:"sec_8",title:"3. PCDD/Fs removal",level:"1"},{id:"sec_8_2",title:"3.1 Catalytic filtration of PCDD/F",level:"2"},{id:"sec_9_2",title:"3.2 Technology DeNOx/DeDiox",level:"2"},{id:"sec_11",title:"4. Experimental evidence of PCDD/Fs in gasification and reliable mitigation",level:"1"},{id:"sec_12",title:"5. Future work or guidelines",level:"1"},{id:"sec_13",title:"6. Conclusions",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"},{id:"sec_17",title:"Conflict of interest",level:"1"},{id:"sec_14",title:"Nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'Chopra S, Jain A. A review of fixed bed gasification systems for biomass. Agric Eng Int CIGR Ejournal 2007;IX:1-23. doi:http://hdl.handle.net/1813/10671.'},{id:"B2",body:'Demirbas AH, Demirbas I. Importance of rural bioenergy for developing countries. Energy Convers Manag 2007;48:2386-2398. doi:10.1016/j.enconman.2007.03.005.'},{id:"B3",body:'Pollex A, Ortwein A, Kaltschmitt M. Thermo-chemical conversion of solid biofuels. Biomass Convers Biorefinery 2012;2:21-39. doi:10.1007/s13399-011-0025-z.'},{id:"B4",body:'Susastriawan AAP, Saptoadi H, Purnomo. Small-scale downdraft gasifiers for biomass gasification: A review. Renew Sustain Energy Rev 2017;76:989-1003. doi:10.1016/j.rser.2017.03.112.'},{id:"B5",body:'Purohit P. 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School of Engineering and Natural Sciences, University of Iceland, VR-II, Hjardarhaga, Reykjavik, Iceland
School of Engineering and Natural Sciences, University of Iceland, VR-II, Hjardarhaga, Reykjavik, Iceland
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1. Introduction
Every year, approximately 338,000 individuals are diagnosed with kidney cancer globally, representing about 2% of all cancers [1]. Renal cell carcinoma (RCC) accounts for approximately 90% of all kidney cancers—affecting an estimated 300,000 people each year [2, 3]. Approximately 30% of kidney cancer patients represent an advanced disease stage at diagnosis, with an average 5-year survival rate of approximately 16% [4, 5].
The management of RCC, regardless of its histological subtype or stage, involves surgical resection of the tumor through either a radical or partial nephrectomy [6]. While surgery is not curative in cases involving metastatic disease, with localized RCC, surgical intervention is considered the optimal standard of care [6, 7].
But despite that, postsurgical recurrence of cancer is a prevalent issue in cases of localized RCC (stage 2 or 3 disease) with a 5-year relapse rate of 30–40% and, as such, surgery is insufficient for long-term disease free survival [8, 9]. Hence, even though the current standard for postoperative care continues to be radiographic surveillance, the need for effective adjuvant therapy for localized high risk for recurrence RCC would be helpful and desired by the surgical community [8, 9, 10].
In view of these findings and the effective treatment of metastatic RCC with Immunotherapy in the 1990s or more recently with targeted therapy, a strong rationale for systemic adjuvant therapy exists in high risk for recurrence patients.
In this chapter, we review different treatment modalities have been used as an adjuvant therapy for nonmetastatic renal cancer postsurgical resection with emphasis on targeted therapy as becoming an option to offer patients.
2. Stratifying risk of recurrence
A critical element in both the testing and effective clinical use of adjuvant therapy involves determining whether there is a high risk of disease recurrence post nephrectomy and accordingly identifying patients that are most likely to benefit from the therapy. As discussed earlier, the determination of recurrence risk is currently nonstandardized in adjuvant therapy testing. Several models and clinical nomograms have been developed to predict the risk of disease recurrence and progression, as well as evaluate additional oncological endpoints [11, 12, 13, 14, 15, 16, 17, 18, 19]. Examples of some validated models include the Cindolo Recurrence Risk Formula, Leibovich scoring system, Karakiewicz scoring system, Kattan nomogram, Mayo Clinic stage, size, grade, and necrosis scoring system (SSIGN), and the University of California Los Angeles Integrated Staging System (UISS) [11, 12, 13, 14, 15, 16, 17, 18, 19] (Tables 1 and 2). These systems usually incorporate information regarding different variables and various prognostic signs and indictors such as tumor size, stage and characteristics, clinical risk factors, and various other pathological features and signs for a relatively robust evaluation [11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21]. Among these models, the UISS, Kattan and SSIGN nomograms have shown relatively better discriminative accuracy in some comparative studies and hence are most commonly utilized [13, 22, 23].
Characteristics
Points
Tumor
pT1a
0
pT1b
2
pT2
3
pT3-pT4
4
Dimension
<10 cm
0
>10 cm
1
Fuhrman
1–2
0
3
1
4
3
Tumor necrosis
Absent
0
Present
1
Lymph nodes
pNx/pN0
0
pN1-pN2
2
Table 1.
Leibovich prognosis score.
T stage
1
2
3
4
Furman grade
1–2
3–4
1–4
1
2–4
1–4
ECOG PS
0
>1
any
>1
any
0
>1
0
>1
any
Risk group
Low
Intermediate
High
Table 2.
UISS prognosis score.
In terms of a general approximation, recurrence risk can be segregated into three broad categories based on the UISS nomogram: low, intermediate and high risk [18]. These three risk groups are differentiated based on the probability of survival and disease recurrence and patients, in a clinical setting, can be stratified through an independent clinical assessment of UISS components, such as tumor stage, grade, and other pathophysiological characteristics [18, 19]. While the UISS components have not been formally validated as independent recurrence risk prediction models, they are important prognostic indicators for various oncological outcomes and endpoints that are invariably linked with the risk of disease relapse [18, 19]. As such, an evaluation of tumor characteristics—particularly tumor stage—can serve as a rough guide for preliminary differentiation between high, intermediate and low risk categories in the clinical setting [24, 25, 26, 27]. This correlation has been supported by independent studies which have reported higher recurrence free survival (RFS) rates for smaller, T1a-T1b stage tumors and lower RFS rates for larger, T3-T4 stage tumors [24, 25, 26, 27]. Thus, patients with T1a-T2a tumors can be estimated to have lower recurrence risk while those with T3b-T4 tumors can be placed into the high-risk category [24, 25, 26, 27]. Among these varying risk levels, currently only those who present a high risk of disease recurrence can potentially benefit from adjuvant therapy postsurgical resection of the tumor.
The incorporation of biotechnology and an improved understanding of genetic and molecular markers may potentially lead to the next major advancement in improving the predictive accuracy of relapse risk. Recent studies have reported the development of novel gene assays and have further elucidated several new biomarkers [28, 29, 30, 31]. Nonetheless, further investigation, testing and development is required before molecular approaches can be incorporated for clinical application in an efficient and economically viable manner.
3. Immunotherapy IL2,IFα
Two trials that used adjuvant IFN-α [32, 33] and one study that used adjuvant high-dose IL-2 (82) were negative for any benefit. The latter study was designed and powered to show an improvement in predicted 2-year DFS from 40% for the observation group to 70% for the treatment group. Despite full accrual 30% improvement in 2-year DFS could not be achieved which lead to early study closure.
Combination treatment with IFN-α and IL2 also failed to improve DFS in one trial [34].
The combination of cytokines with 5-fluorouracil (5-FU) also failed to improve DFS in the adjuvant setting [35, 36].
In one randomized adjuvant trial, triple combination therapy using IL-2, IFN-α, and5-FU was associated with significant toxicity which leads to 35% of the patients did not complete the study and also resulted in no benefit in DFS or OS [37].
4. Tumor vaccines
Autologous irradiated tumor cells mixed with bacillus Calmette-Guérin (BCG) were tested in two randomized trials and did not result in prolonged DFS [38, 39, 40].
Similarly, autologous, tumor-derived heat-shock protein (glycoprotein 96)-peptide complex (HSPPC-96; vitespen) did not result in a statistically significant improvement of DFS [41].
A trial with an autologous renal tumor cell vaccine only reported improved DFS in the vaccine group [42], but the number of patients lost after the randomization step, the imbalance of this loss, and the absence of tabulation of OS led to criticism of the results [43].
This therapy has not been implemented in routine clinical practice.
5. Hormonal therapy
The occasional response of patients with metastatic RCC to hormonal therapy with medroxyprogestrone acetate (MPA) provided a rationale in trying it in adjuvant sitting.
In a prospective randomized trial of adjuvant MPA after radical nephrectomy, 136 patients received either MPA 500 g (three times a week) for 1 year or observation. With a median follow up of 5 years. There were no significant differences in relapses between the adjuvant group and the observation group (32.7 vs. 33.9%, respectively) [44].
6. Radiotherapy
Radiotherapy has been used for symptoms palliation in metastatic RCC like hematuria and painful bone metastasis. Also, long-term PFS has been reported for in a subset of patients following radiotherapy for solitary bone metastases [31].
One prospective, randomized study in 72 patients comparing administration of radiation of the kidney bed, and ipsilateral and contralateral lymph nodes for stages II and III RCC versus observation reported relapse rates of 48% in both groups. Forty-four percent of patients in the radiotherapy arm had significant complications that contributed to the death of 19% of patients [45, 46, 47].
7. Adjuvant therapy in the era of the new targeted therapy
7.1. Targeted therapy
Systemic therapy for mRCC has particularly changed over the last decade with the introduction of targeted therapy and the evolvement of tyrosine kinase inhibitors (TKI) [7, 49, 50, 51, 52, 53]. This development has directly resulted from an improved understanding of the pathogenesis and molecular biology of RCC [49, 50, 51, 52, 53, 54]. TKIs have provided a novel therapeutic approach for better managing the pathology through the inhibition of targets such as the mammalian target of rapamycin (mTOR) pathway and the vascular endothelial growth factor receptor (VEGFR), which consequently help inhibit processes that are critical for cancer progression [7, 49, 50, 51, 52, 53]. Particularly in cases of metastatic RCC, these inhibitors have been effective in increasing the overall survival and response rates than previously used immunotherapy and chemotherapy agents [7, 49, 50, 51, 52, 53].
Seven drugs are now approved for targeted therapy, and several others are being evaluated in clinical trials [50, 51, 52, 53, 55]. At the molecular level, the mechanism of these drugs involves interrupting the molecular signal transduction of various signaling pathways which then ultimately affects pathogenic factors like tumor vascularity, growth and progression [50, 51, 52, 53, 55]. Sunitinib and Pazopanib are currently the accepted standard of care for the management of metastatic RCC and are the most widely used first line agent due to their robust clinical efficacy and established toxicity profile [50, 51, 52, 53, 55]. The current set of therapeutic agents used in targeted therapy exploit the Von Hippel-Lindau (VHL) and hypoxia-inducible factor (HIF) pathway associated with clear cell RCC pathogenesis [56, 57].
7.2. VHL-HIF pathway
Clear Cell RCC (ccRCC) normally entails a biallelic inactivation of the VHL tumor suppressor gene at the 3p25-26 locus. VHL inactivation, which occurs due to factors such as mutation, hyper-methylation, or deletions, results in the formation of defective pVHL protein—ultimately leading to the activation and upregulation of HIF-1α [56, 57]. Activated HIF protein serves as a transcription factor for various pro-tumorigenic target genes such as vascular endothelial growth factor (VEGF), transforming growth factor-α and platelet-derived growth factor (PDGF) that are involved in pathogenic processes like angiogenesis, tumor cell proliferation and cell survival [56, 57]. Apart from this central pathway, the mTOR pathway also intersects with HIF pathway upstream of the VHL gene and hence also plays a critical role in influencing HIF process and function [56, 57]. Thus, inhibiting different targets in this pathway has yielded favorable results in mRCC cases [50, 51, 52, 53, 55, 56, 57]. Given the success of targeted therapy agents in the metastatic setting, recent efforts have been focused into translating this into the adjuvant setting.
7.3. Clinical trials: targeted therapy in adjuvant setting
The contemporary endeavors to transpose targeted therapy in the adjuvant setting have been inspired by the increased clinical knowledge gained through the development and evaluation of interventions for stage IV disease [9, 10, 58, 59]. There are currently seven multicenter, double-blind, placebo-controlled, randomized adjuvant clinical trials, involving targeted therapy agents [9, 10, 58, 59]. Five of these trials involve tyrosine kinase inhibitors, while one involves an mTOR inhibitor and the other a monoclonal chimeric antibody [9, 10, 58, 59, 60, 61, 62, 63]. So far, four of these trials have been completed including the, ARISER, ASSURE, S-TRAC and PROTECT trials while the other ones are still in progress [60, 61, 62, 63].
7.3.1. ARISER trial
This ARISER trial, completed in 2014, evaluated the efficacy of girentuximab [60], a monoclonal antibody to carbonic anhydrase IX (a HIF downstream target gene), in the adjuvant setting for intermediate to high risk for recurrence patients. This multicenter, phase III trial involved 864 patients with resected clear cell tumors, who were randomized to receive either girentuximab or placebo, once a week, for 24 weeks. Girentuximab recipients received a 50 mg dose during the first week followed by a weekly dose of 20 mg for the next 23 weeks. The median disease free survival (DFS) duration for the participants in the intervention arm was 71.4 months (HR: 0.97; 95% CI, 0.79–1.18) while the endpoint was never reached for the placebo group. As such, the study indicated no interventional advantage but it recommended further investigation of adjuvant girentuximab in patients with high levels of CAIX in affected renal tissue.
7.3.2. ASSURE trial
The ASSURE trial, completed in 2016, was a randomized, double-blind, placebo-controlled, phase 3 clinical trial in which 1943 patients from 226 study centers in North America were assigned to one of three intervention arms—sunitinib, sorafenib or placebo in intermediate to high-risk patients [61]. Sunitinib patients received 50 mg for 54 weeks on a 4 of 6 week cycle; sorafenib recipients received 400 mg twice per day throughout each cycle, and placebo recipients were randomly assigned either the sunitinib placebo or the sorafenib placebo. The interventions were evaluated using DFS as the primary endpoint. Trial results indicated that the median DFS duration was approximately 5.8 years for sunitinib [HR: 1.02; 97.5% CI: 0.85–1.23; P = 0.8038], 6.1 years for sorafenib (HR: 0.97; 97.5% CI: 0.80–1.17; P = 0.7184), and 6.6 years for placebo—hence suggesting no survival benefit from the interventions relative to the placebo. Instead, the results further reported detrimental effects due to the increased toxicity of the treatment despite the dose reductions—suggesting no benefit of the particular TKI in the adjuvant setting. Of note, this trial had a higher number of TKI dose reductions (potentially suggesting suboptimal drug dosing) and more intermediate risk for recurrence patients than other trials.
7.3.3. S-TRAC trial
The S-TRAC study, also completed in 2016, was a prospective, randomized, double-blind, phase 3 clinical trial involving 615 patients from 21 countries [62]. Of the 615 patients who underwent randomization, 309 were assigned to the sunitinib arm and 306 to the placebo arm. These patients were all “high risk of recurrence.” Sunitinib recipients received 50 mg for a year on a 4 of 6 week cycle. The interventions were evaluated by comparing DFS, the primary endpoint of the study, between the two trial arms. The study results indicated that the median DFS duration was 6.8 years (95% CI: 5.8 to not reached) in the sunitinib group and 5.6 years (95% CI: 3.8–6.6) in the placebo group (HR: 0.76; 95% CI: 0.59–0.98; P = 0.03). The adverse effects observed in sunitinib recipients were consistent with its known toxicity profile. As such, the results from this trial support the potential for sunitinib as a treatment option in the adjuvant setting with a DFS advantage. However, overall survival endpoints have not yet been reported.
7.3.4. PROTECT trial
The PROTECT study, completed recently in 2017, was a phase 3 randomized clinical trial that evaluated the efficacy of adjuvant pazopanib as compared to placebo in preventing RCC recurrence in intermediate to high-risk patients [63]. The trial enrolled 1538 participants and the majority of the pazopanib recipients received a revised dosage of 600 mg, daily for a year, following a dose reduction from 800 mg which caused severe side effects. The interventions were evaluated by comparing DFS as the primary endpoint measure between the two trial arms. The study did not meet its primary endpoint and indicated no significant benefit of pazopanib-600 mg in prolonging DFS as compared to placebo (HR: 0.86; 95% CI, 0.70–1.06; P = 0.165). However, a subgroup analysis of pazopanib-800 mg recipients indicated a 31% decline in DFS (HR, 0.69; 95% CI, 0.51–0.94; P = 0.02). While the DFS results were conflicting between the 600 mg and 800 mg groups, the study reported similar adverse event profiles between both the groups.
7.3.5. Comparison of current adjuvant trial design
The differing outcomes that have been indicated in the current set of completed trials may be accounted for by the distinct sample groups, dose regimens, risk assessment criteria and trial methods [60, 61, 62, 63]. This collectively represents a fundamental limitation that underscores all current adjuvant clinical trials. First, the patient inclusion criteria characteristically differ, in multiple ways, across all adjuvant trials [60, 61, 62, 63]. For example, in the S-TRAC trial, the selected sample exclusively included patients with late-stage, loco-regional, clear-cell RCC while other trials such as the ASSURE, ARTISER and PROTECT trials used a less restricted criteria and included patients with stage 1 or stage 2 tumors and non-clear-cell histologies [60, 61, 62, 63]. In addition, another major cause of heterogeneity lies in the risk assessment and stratification criteria as the scoring system used in the current set of adjuvant trials are not standardized, and hence this invariably contributes to a varied assessment of recurrence risk [60, 61, 62, 63]. With respect to the conflicting sunitinib trials (S-TRAC vs. ASSURE), additional sources of variation that might have led to inconsistent outcomes include varying dose regimens, specifically with respect to the midtrial dose reductions for sunitinib, as well as differing trial criteria for establishing disease status and assessing primary end point status [61, 62, 64].
7.4. Targeted immunomodulatory therapy
The development of therapy that targets oncogenic signaling pathways has advanced the treatment landscape for patients with advanced renal cell carcinoma. While nonspecific immunotherapy with IL-2 and IFN-α was the former mainstay in the management of metastatic disease, there was a shift away from it with the advent of targeted therapy which yielded relatively better response rates [32, 33, 34, 48, 49, 50, 51, 52, 53, 54, 65, 66, 67, 68]. However, over the last couple of years, cancer immunotherapy has been revisited and, as a result, targeted immunomodulatory therapy, involving novel immunomodulating agents, has been reincorporated in combination therapy regimes for mRCC management—hence allowing for an induced immuonologic effect in addition to the inhibitory effect on tumor biology and microenvironment [69, 70]. This has been inspired in part by disease resistance that is progressively manifesting itself against standard targeted therapy in the landscape of metastatic disease management [69, 70].
Given that multiple mechanisms are employed by tumors to evade and suppress the immune system, research toward better understanding those mechanisms of immunomodulation has been critical in informing the therapeutic landscape [69, 71]. Particularly, an improved understanding of the factors regulating the antitumor immune response has led to the development a novel form of cancer immunotherapy involving checkpoint inhibitors and other immune therapies such as T-cell agonists, adoptive T-cell therapies and novel vaccines which are being evaluated across different trials for metastatic RCC [69, 71].
7.5. Immune checkpoint inhibitors
Immune checkpoints serve a critical protective function of preventing immune response against host cells through a series of complex interactions [71, 72, 73]. However, investigation into the pathogenic mechanisms of RCC revealed that cancer cells can induce similar interactions with host checkpoint receptors and can hence suppress the human immune response [71, 72, 73]. Immune checkpoint inhibitors counter these molecular mechanisms through which tumor cells evade immune recognition [71, 72, 73].
Programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) are currently the most well understood inhibitory checkpoint receptors [71, 72, 73]. The PD-1/PD-L1 axis involves an inhibitory interaction between a T-cell inhibitory ligand PD-L1, expressed on tumor cell surface, and a PD-1 receptor on the lymphocyte [71, 72, 73]. Hence, mimicking this interaction ultimately allows tumor cells to evade the adaptive immune response through suppression of T-cell function. The CTLA-4 pathway is similarly exploited by tumor cells [71, 72, 73]. During an adaptive immune response, immune activation occurs through an interaction between the T-cell receptor (TCR) and the antigen-presenting cell (APC) along with the co-stimulation of CD28 on the T cell [71, 72, 73]. This activation is negatively regulated by an inhibitory interaction between CTLA-4 and its ligands—CD80 or CD86 [71, 72, 73]. Thus, the targeted inhibition of these checkpoint receptors through targeted antibodies, in both the pathways mentioned above, could allow for T-cell activation and effective immune function [71, 72, 73].
The first checkpoint inhibitor which demonstrated a survival benefit in patients with metastatic RCC was nivolumab—an anti-PD1 monoclonal antibody [74]. The inhibitor, which received FDA approval in 2015 based on the results from a trial evaluating nivolumab versus everolimus, is effective in yielding positive response rates when used for treatment of advanced RCC in patients who have undergone prior anti-angiogenic therapy [74]. Apart from nivolumab, multiple other checkpoint inhibitors are being currently evaluated in different trials against advanced RCC [71, 72, 73].
7.6. Immunomodulatory therapy in the adjuvant setting
Given their recent development, many immune checkpoint inhibitors are still being evaluated for their efficacy and toxicity against metastatic RCC, and hence investigation of these inhibitors in the adjuvant setting has been limited. Currently, there are a few ongoing clinical trials that are evaluating different checkpoint inhibitors in both the adjuvant setting as well as the neo-adjuvant (presurgery) setting (Table 3) [75, 76, 77, 78].
Adjuvant clinical trials in RCC using immune therapies
At 10.4 years median follow-up: Median survival: 7.4 years (control) vs. 5.1 years (treatment) (P ¼ _0.09). DFS: 3.0 years (control) vs. 2.2 years (treatment) (P ¼ _0.33)
At 5-year follow-up: DFS: 67.8% (control) vs. 77.4% (treatment) (P ¼ _0.0204). At 70-month follow-up: DFS: 59.3% (control) vs. 72% (treatment). HR for tumor progression: 1.58 (95% CI 1.05–2.37) and 1.59 (1.07–2.36) (P ¼ _0.0204)
Table 3.
Adjuvant clinical trials in RCC using immune therapies.
The IMmotion, KEYNOTE-564, and CheckMate 914 are phase III trials evaluating the efficacy and safety of adjuvant atezolizumab, pembrolizumab, and nivolumab/ipilimumab (combinational regimen) respectively in prolonging the DFS of RCC patients who are at high risk of disease recurrence post nephrectomy [75, 77, 78]. In addition to the adjuvant trials, an ongoing study in the neo-adjuvant setting includes the PROSPER trial which is evaluating the efficacy of pre-nephrectomy nivolumab [75]. These trials, which have either started already or are expected to begin later this year, are currently in their recruitment or pre-recruitment phases and are anticipated to be completed by 2022–2024 [75, 77, 78]. Apart from these clinical studies, there are several checkpoint inhibitors that are in development as well as others that are currently being evaluated in trials for mRCC and would subsequently be assessed in the adjuvant setting [71, 72, 73] (Tables 4–6).
Any; pT1bN0M0 (grades 3–4) or pT2-4N1-3M0 (risk: intermediate-high)
DFS
2021
Table 5.
Current set of adjuvant clinical trials that are still in progress.
Trial name
Trial ID
Intervention
Estimated enrollment
Primary endpoint measure
Start date
Completion date
PROSPER
NCT03055013
Nivolumab (pre-Nx)
766
DFS
February 2, 2017
2022
KEYNOTE-564
NCT03142334
Pembrolizumab
950
DFS
June 9, 2017
2022
CheckMate 914
NCT03138512
Nivolumab, ipilimumab
800
DFS
July 3, 2017
2023
IMmotion010
NCT03024996
Atezolizumab
664
DFS
January 3, 2017
2024
Table 6.
Ongoing adjuvant and neo-adjuvant clinical trials.
7.7. Change of practice
The European Association of Urology Renal Cell Cancer Guidelines Panel, which includes patient representatives and clinicians, considered a number of different scenarios to determine what would be required from S-TRAC to change practice. The decision on practice change was taken in the context of the data from ASSURE. Results showed that only 1 out of 15 (6%) of the panel would change their standard of care when considering the DFS and OS closest to S-TRAC (DFS: HR 0.75, p < 0.05; OS: HR 1.0, p > 0.05). Standard practice would only be significantly influenced by a significant survival benefit. In addition, kidney cancer patients from the International Kidney Cancer Coalition (IKCC) participated in a questionnaire about the implications for STRAC. The results lacked clarity. Twenty-two patient representatives from the IKCC network were asked what degree of PFS advantage would be needed to justify taking sunitinib for 1 year. Approximately one-third of patients favored not taking sunitinib when faced with the S-TRAC results [79].
Recently, on November 2017, the FDA approved the use sunitinib for the adjuvant treatment of adult patients at high risk of recurrent renal cell carcinoma following nephrectomy. The approval was based on (S-TRAC) trail.
8. Conclusions and future directions
Targeted therapy has become the current mainstay in the management of metastatic RCC and its success with advanced stage disease has been the driving force behind the increasing number of targeted therapy trials in the adjuvant setting. The emergence of immune checkpoint inhibitors in the last couple of years has further led to important advances in our understanding and management of mRCC. However, many ongoing trials are yet to be completed in both cases and there is ample potential for further investigation—especially with respect to combinational therapy regimes. This includes the combination of TKIs with immune therapies (e.g., NCT01513187: Pazopanib with Interferon Alfa 2-A), combination of TKIs with chemotherapeutics (e.g., NCT00556049: Sunitinib with Gemcitabine), and the combination of anti-VEGF antibodies and mTOR inhibitors (e.g., NCT01399918: bevacizumab and everolimus). All of these treatments may be of interest for future adjuvant trials in RCC if they are found to be effective in stage IV disease. However, they may have more side effects, making them less suitable in particular for adjuvant treatment. Nonetheless, the current information, which has resulted from all the progress in the field, remains incongruent. While the current set of completed adjuvant clinical trials have provided negative or conflicting results (ARISER, PROTECT, S-TRAC vs. ASSURE), there are additional large-scale trials that are still in progress. The existing trial design has several limitations, the key one being the overall lack of standardization seen across various assessment criteria. Future directions include incorporating a genetic recurrence score to evaluate risk of relapse in patients, developing an adequate and an objectively standardized adjuvant trial design, identifying novel biomarkers and evaluating novel drug targets.
That based on results from current trials, the “high risk for recurrence” RCC patient population (T3-T4, grade 3-4) may benefit from adjuvant sunitinib providing DFS advantage but pending OS results. Patients, in this category, interested in adjuvant therapy would benefit from a discussion with an oncologist regarding the potential benefits and risks of adjuvant treatment post kidney cancer surgery. Overall, the landscape of adjuvant treatment in nonmetastatic high-risk RCC is expected to expand and to further develop in the coming years.
\n',keywords:"renal cell carcinoma, adjuvant treatment for RCC, treatment of high-risk RCC, targeted therapy as adjuvant",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/62949.pdf",chapterXML:"https://mts.intechopen.com/source/xml/62949.xml",downloadPdfUrl:"/chapter/pdf-download/62949",previewPdfUrl:"/chapter/pdf-preview/62949",totalDownloads:814,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 21st 2017",dateReviewed:"May 14th 2018",datePrePublished:"November 5th 2018",datePublished:"July 22nd 2020",dateFinished:"August 6th 2018",readingETA:"0",abstract:"Renal cell carcinoma accounts for about 2% of all adult malignancies. More than 300,000 individuals are affected each year. Unfortunately, around 30% of cases are discovered in advanced stages. Surgical resection remains the mainstay of treatment for localized disease and relapses can reach up to 40% in some cases. The effective treatment of metastatic RCC with systemic targeted therapy gives a strong rationale for its use as adjuvant treatment in high-risk patients. This chapter reviews different modalities that have been used as an adjuvant therapy for nonmetastatic renal cancer. Clinical trials using targeted therapy are discussed in detail, as they are becoming options for treatment in high-risk patients. While the current set of completed adjuvant clinical trials have provided conflicting results, there are additional large-scale trials that are still in progress. Future directions include—incorporating a genetic recurrence score to evaluate risk of relapse in patients, developing an adequate and an objective standardized adjuvant trial design, identifying novel biomarkers, and evaluating novel drug targets. Based upon current clinical trial evidence, motivated high-risk patients should have a discussion with the urology oncology team regarding the benefits of adjuvant TKI sunitinib or consider enrollment in current ongoing immuno-oncology (IO) adjuvant clinical trials.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/62949",risUrl:"/chapter/ris/62949",signatures:"Fadil Hassan, Shahid Lambe, Kiran Sharma and Anil Kapoor",book:{id:"6424",type:"book",title:"Evolving Trends in Kidney Cancer",subtitle:null,fullTitle:"Evolving Trends in Kidney Cancer",slug:"evolving-trends-in-kidney-cancer",publishedDate:"July 22nd 2020",bookSignature:"Sashi S. Kommu and Inderbir S. Gill",coverURL:"https://cdn.intechopen.com/books/images_new/6424.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83881-960-6",printIsbn:"978-1-83881-959-0",pdfIsbn:"978-1-83881-964-4",isAvailableForWebshopOrdering:!0,editors:[{id:"9902",title:"Dr.",name:"Sashi S.",middleName:"S",surname:"Kommu",slug:"sashi-s.-kommu",fullName:"Sashi S. Kommu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"69038",title:"Dr.",name:"Anil",middleName:null,surname:"Kapoor",fullName:"Anil Kapoor",slug:"anil-kapoor",email:"akapoor@mcmaster.ca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/69038/images/5805_n.jpg",institution:{name:"McMaster University",institutionURL:null,country:{name:"Canada"}}},{id:"216072",title:"Ms.",name:"Camilla",middleName:null,surname:"Tajzler",fullName:"Camilla Tajzler",slug:"camilla-tajzler",email:"tajzlec@mcmaster.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"McMaster University",institutionURL:null,country:{name:"Canada"}}},{id:"240318",title:"Dr.",name:"Fadil",middleName:null,surname:"Hassan",fullName:"Fadil Hassan",slug:"fadil-hassan",email:"drhassanfi@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"McMaster University",institutionURL:null,country:{name:"Canada"}}},{id:"240320",title:"Dr.",name:"Shahid",middleName:null,surname:"Lambe",fullName:"Shahid Lambe",slug:"shahid-lambe",email:"shahidlambe@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"McMaster University",institutionURL:null,country:{name:"Canada"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Stratifying risk of recurrence",level:"1"},{id:"sec_3",title:"3. Immunotherapy IL2,IFα",level:"1"},{id:"sec_4",title:"4. Tumor vaccines",level:"1"},{id:"sec_5",title:"5. Hormonal therapy",level:"1"},{id:"sec_6",title:"6. Radiotherapy",level:"1"},{id:"sec_7",title:"7. Adjuvant therapy in the era of the new targeted therapy",level:"1"},{id:"sec_7_2",title:"7.1. Targeted therapy",level:"2"},{id:"sec_8_2",title:"7.2. VHL-HIF pathway",level:"2"},{id:"sec_9_2",title:"7.3. Clinical trials: targeted therapy in adjuvant setting",level:"2"},{id:"sec_9_3",title:"7.3.1. ARISER trial",level:"3"},{id:"sec_10_3",title:"7.3.2. ASSURE trial",level:"3"},{id:"sec_11_3",title:"7.3.3. S-TRAC trial",level:"3"},{id:"sec_12_3",title:"7.3.4. PROTECT trial",level:"3"},{id:"sec_13_3",title:"7.3.5. Comparison of current adjuvant trial design",level:"3"},{id:"sec_15_2",title:"7.4. Targeted immunomodulatory therapy",level:"2"},{id:"sec_16_2",title:"7.5. Immune checkpoint inhibitors",level:"2"},{id:"sec_17_2",title:"7.6. Immunomodulatory therapy in the adjuvant setting",level:"2"},{id:"sec_18_2",title:"7.7. Change of practice",level:"2"},{id:"sec_20",title:"8. Conclusions and future directions",level:"1"}],chapterReferences:[{id:"B1",body:'Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide. Lyon, France: International Agency for Research on Cancer; 2010'},{id:"B2",body:'Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2015. Toronto, ON: Canadian Cancer Society; 2015'},{id:"B3",body:'Renal Cell Carcinoma. Cleveland Clinic. 2013. Available from: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/nephrology/renal-cell-carcinoma/'},{id:"B4",body:'Kidney Cancer Association. About Kidney Cancer. October, 2016. 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European Urology. 1982;8:340-342'},{id:"B46",body:'Mogens K, Frederiksen PL, Engelholm S. Postoperative radiotherapy in stage II and III renal adenocarcinoma. A randomized trial by the Copenhagen renal cancer study group. International Journal of Radiation Oncology Biology Physics. 1987;13(5):665-672'},{id:"B47",body:'Mogens K et al. A randomized trial of postoperative radiotherapy versus observation in stage II and III renal adenocarcinoma: A study by the Copenhagen Renal Cancer Study Group. Scandinavian Journal of Urology and Nephrology. 1987;21(4):285-289'},{id:"B48",body:'Clark JI et al. Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: A cytokine working group randomized trial. Journal of Clinical Oncology. 2003;21(16):3133-3140'},{id:"B49",body:'Escudier B, Albiges L, Sonpavde G. Optimal management of metastatic renal cell carcinoma: Current status. Drugs. 2013;73(5):427-438'},{id:"B50",body:'Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. The New England Journal of Medicine. 2007;356(2):115-124'},{id:"B51",body:'Motzer R, Hutson T, Tomczak P, Michaelson M, Bukowski R, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology. 2009;27(22):3584-3590'},{id:"B52",body:'Powles T, Chowdhury S, Jones R, Mantle M, Nathan P, Bex A, et al. Sunitinib and other targeted therapies for renal cell carcinoma. British Journal of Cancer. 2011;104(5):741-745'},{id:"B53",body:'Coppin C, Kollmannsberger C, Le L, Porzsolt F, Wilt T. Targeted therapy for advanced renal cell cancer (RCC): A cochrane systematic review of published randomised trials. BJU International. 2011;108(10):1556-1563'},{id:"B54",body:'Pal SK, Williams S, Josephson DY, et al. Novel therapies for metastatic renal cell carcinoma: Efforts to expand beyond the VEGF/mTOR signaling paradigm. Molecular Cancer Therapeutics. 2012;11:526-537'},{id:"B55",body:'Ljunberg et al. Guidelines on Renal Cell Carcinoma. European Association of Urology. 2015. Available from: http://uroweb.org/wp-content/uploads/10-Renal-Cell-Carcinoma_LR1.pdf'},{id:"B56",body:'Ellis L, Hicklin D. VEGF-targeted therapy: Mechanisms of anti-tumour activity. Nature Reviews. Cancer. 2008;8(8):579-591'},{id:"B57",body:'Baldewijns M, van Vlodrop I, Vermeulen P, Soetekouw P, van Engeland M, de Bruïne A. VHL and HIF signalling in renal cell carcinogenesis. The Journal of Pathology. 2010;221(2):125-138'},{id:"B58",body:'Pal SK, Bergerot P, Figlin RA. Renal cell carcinoma: An update for the practicing urologist. Asian Journal of Urology. 2015;2(1):19-25'},{id:"B59",body:'Patel D, Figlin R, Kim H. Adjuvant treatment for renal cell carcinoma: Do we finally have a major breakthrough? Clinical Advances in Hematology & Oncology. 2016;14(11)'},{id:"B60",body:'Chamie K, Donin NM, Klöpfer P, Bevan P, Fall B, Wilhelm O, Störkel S, Said J, Gambla M, Hawkins RE, Jankilevich G, Kapoor A, Kopyltsov E, Staehler M, Taari K, Wainstein AJA, Pantuck AJ, Belldegrun AS. Phase III ARISER data for the adjuvant treatment of clear cell renal cancer with RENCAREX® including retrospective subgroup analysis. Presented at ASCO; 1-3 June, 2013'},{id:"B61",body:'Haas NB, Manola J, Uzzo RG, et al. Adjuvant sunitinib or sorafenib for high-risk, non-metastatic renal-cell carcinoma (ECOG-ACRIN E2805): A double-blind, placebo-controlled, randomised, phase 3 trial. Lancet. 2016;387:2008-2016'},{id:"B62",body:'Ravaud A, Motzer RJ, Pandha HS, et al. Adjuvant sunitinib in high-risk renal-cell carcinoma after nephrectomy. The New England Journal of Medicine. 2016;375:2246-2254. DOI: 10.1056/NEJMoa1611406'},{id:"B63",body:'RJM M, Naomi HB, et al. Randomized phase III trial of adjuvant pazopanib versus placebo after nephrectomy in patients with locally advanced renal cell carcinoma (RCC) (PROTECT). Journal of Clinical Oncology. 2017;35(15_suppl):4507-4507'},{id:"B64",body:'Porta C, Chiellino S. ASSURE vs. S-TRAC: Conflicting results of adjuvant treatments for kidney cancer in the era of targeted agents and genomics. Annals of Translational Medicine. 2016;4(Suppl 1)'},{id:"B65",body:'Atzpodien J, Kirchner H, Illiger HJ. IL-2 in combination with IFN- alpha and 5-FU versus tamoxifen in metastatic renal cell carcinoma: Long-term results of a controlled randomized clinical trial. British Journal of Cancer. 2001;85(8):1130-1136'},{id:"B66",body:'Atzpodien J, Kirchner H, Jonas U. Interleukin-2- and interferon alfa-2a-based immunochemotherapy in advanced renal cell carcinoma: A prospectively randomized trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). Journal of Clinical Oncology. 2004;22(7):1188-1194'},{id:"B67",body:'Atzpodien J, Schmitt E, Gertenbach U. Adjuvant treatment with interleukin-2- and interferon-alpha2a-based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: Results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN). British Journal of Cancer. 2005;92(5):843-846'},{id:"B68",body:'Aitchison M, Bray C, Van Poppel H, Sylvester R, Graham J, Innes C, McMahon LVP. Preliminary results from a randomized phase III trial of adjuvant interleukin-2, interferon alpha and 5-fluorouracil in patients with a high risk of relapse after nephrectomy for renal cell carcinoma (RCC). Journal of Clinical Oncology. 2008;26(suppl):5040. abstr'},{id:"B69",body:'De Maeseneer D, Delafontaine B, Rottey S. Checkpoint inhibition: New treatment options in urologic cancer. Acta Clinica Belgica. 2017;72(1):24-28'},{id:"B70",body:'Kuusk T, Albiges L, Escudier B, Grivas N, Haanen J, Powles T, et al. Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer. Angiogenesis. 2017'},{id:"B71",body:'Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011;480:480-489'},{id:"B72",body:'Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nature Reviews. Cancer. 2012;12:252-264'},{id:"B73",body:'Carlo M, Voss M, Motzer R. Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma. Nature Reviews. Urology. 2016;13(7):420-431'},{id:"B74",body:'Motzer R, Escudier B, McDermott D, George S, Hammers H, Srinivas S, et al. Nivolumab versus Everolimus in advanced renal-cell carcinoma. The New England Journal of Medicine. 2015 Nov 5;373(19):1803-1813. DOI: 10.1056/NEJMoa1510665. Epub 2015 Sep 25'},{id:"B75",body:'US National Library of Medicine. ClinicalTrials.gov. 2017. https://clinicaltrials.gov/ct2/show/NCT03055013'},{id:"B76",body:'US National Library of Medicine. ClinicalTrials.gov. 2017. https://clinicaltrials.gov/ct2/show/NCT03142334'},{id:"B77",body:'US National Library of Medicine. ClinicalTrials.gov. 2017. https://clinicaltrials.gov/ct2/show/NCT03138512'},{id:"B78",body:'US National Library of Medicine. ClinicalTrials.gov. 2017. https://clinicaltrials.gov/ct2/show/NCT03024996'},{id:"B79",body:'Bex A, Albiges L, Ljungberg B, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB, Marconi L, Merseburger AS, Staehler M, Volpe A, Powles T. Updated European Association of Urology Guidelines regarding adjuvant therapy for renal cell carcinoma. European Urology. May 2017;71(5):719-722. DOI: 10.1016/j.eururo.2016.11.034'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Fadil Hassan",address:null,affiliation:'
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The performance of UV photosensor is associated with the high surface-to-volume ratio, porosity, surface defects, light trapping, and the intensity of the UV radiation. One-dimensional (1D) growth of TiO2 nanorod arrays (TNAs) offers an enhance charge carrier mobility to overcome the photocurrent loss due to the existence of multiple grain boundaries in granular-like and porous nanostructures. Photoelectrochemical cell (PEC)-based device structure is preferred in TNA-based UV photosensor due to its low cost, facile fabrication process, high contact area, low recombination of the excitonic charge carriers, high photocurrent gain, and fast response and recovery times. It also could work in applied bias mode, as well as in “self-powered” mode. Our study has introduced a new one-step method to deposit a thin film TNA on an FTO-coated glass substrate at low temperature and a rapid process using a facile glass container. 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The I-V characteristics showed that Al-doped sample possesses higher conductivity. From the humidity sensing performance of the samples, Al-doped ZnO nanorod arrays possess the superior sensitivity, more than two times higher than that of the undoped ZnO nanorod arrays sample, demonstrating great potential of Al-doped ZnO nanorod arrays in humidity sensor applications.",signatures:"Ahmad Syakirin Ismail, Mohamad Hafiz Mamat and Mohamad\nRusop Mahmood",authors:[{id:"101789",title:"Dr.",name:"Mohamad Hafiz",surname:"Mamat",fullName:"Mohamad Hafiz Mamat",slug:"mohamad-hafiz-mamat",email:"hafiz_030@yahoo.com"},{id:"108886",title:"Dr.",name:"Mohamad Rusop",surname:"Mahmood",fullName:"Mohamad Rusop Mahmood",slug:"mohamad-rusop-mahmood",email:"rusop@salam.uitm.edu.my"},{id:"196769",title:"Mr.",name:"Ahmad Syakirin",surname:"Ismail",fullName:"Ahmad Syakirin Ismail",slug:"ahmad-syakirin-ismail",email:"kyrin_samaxi@yahoo.com"}],book:{id:"5734",title:"Nanostructured Materials",slug:"nanostructured-materials-fabrication-to-applications",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"99043",title:"Prof.",name:"P K",surname:"Giri",slug:"p-k-giri",fullName:"P K Giri",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99043/images/1207_n.gif",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Guwahati",institutionURL:null,country:{name:"India"}}},{id:"99189",title:"Dr.",name:"Babak",surname:"Sadeghi",slug:"babak-sadeghi",fullName:"Babak Sadeghi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99189/images/122_n.jpg",biography:null,institutionString:null,institution:{name:"Islamic Azad University Tonekabon",institutionURL:null,country:{name:"Iran"}}},{id:"100878",title:"Dr.",name:"Mariana",surname:"Chirea",slug:"mariana-chirea",fullName:"Mariana Chirea",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Porto",institutionURL:null,country:{name:"Portugal"}}},{id:"102290",title:"Dr.",name:"Oleg",surname:"Kononenko",slug:"oleg-kononenko",fullName:"Oleg Kononenko",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Institute of Microelectronics Technology and High Purity Materials",institutionURL:null,country:{name:"Russia"}}},{id:"104854",title:"Prof.",name:"Chu-Chi",surname:"Ting",slug:"chu-chi-ting",fullName:"Chu-Chi Ting",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Chung Cheng University",institutionURL:null,country:{name:"Taiwan"}}},{id:"107453",title:"Dr.",name:"Masanobu",surname:"Iwanaga",slug:"masanobu-iwanaga",fullName:"Masanobu Iwanaga",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Institute for Materials Science",institutionURL:null,country:{name:"Japan"}}},{id:"108880",title:"Mr.",name:"Soumen",surname:"Dhara",slug:"soumen-dhara",fullName:"Soumen Dhara",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Guwahati",institutionURL:null,country:{name:"India"}}},{id:"108882",title:"MSc.",name:"Zuraida",surname:"Khusaimi",slug:"zuraida-khusaimi",fullName:"Zuraida Khusaimi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi MARA",institutionURL:null,country:{name:"Malaysia"}}},{id:"108884",title:"BSc.",name:"Musa",surname:"Mohamed Zahidi",slug:"musa-mohamed-zahidi",fullName:"Musa Mohamed Zahidi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi MARA",institutionURL:null,country:{name:"Malaysia"}}},{id:"108886",title:"Dr.",name:"Mohamad Rusop",surname:"Mahmood",slug:"mohamad-rusop-mahmood",fullName:"Mohamad Rusop Mahmood",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi MARA",institutionURL:null,country:{name:"Malaysia"}}}]},generic:{page:{slug:"OA-publishing-fees",title:"Open Access Publishing Fees",intro:"
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Services included are:
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An online manuscript tracking system to facilitate your work
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Personal contact and support throughout the publishing process from your dedicated Author Service Manager
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Assurance that your manuscript meets the highest publishing standards
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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
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XML Typesetting and pagination - web (PDF, HTML) and print files preparation
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Discoverability - electronic citation and linking via DOI
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Permanent and unrestricted online access to your work
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If your manuscript:
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Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
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If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
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Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
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Open Access Funding
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To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
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For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
\n\n
Added Value of Publishing with IntechOpen
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Choosing to publish with IntechOpen ensures the following benefits:
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Indexing and listing across major repositories, see details ...
\n\t
Long-term archiving
\n\t
Visibility on the world's strongest OA platform
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Live Performance Metrics to track readership and the impact of your chapter
\n\t
Dissemination and Promotion
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Benefits of Publishing with IntechOpen
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Proven world leader in Open Access book publishing with over 10 years experience
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+5,700 OA books published
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Most competitive prices in the market
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Fully compliant with OA funding requirements
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Optimized processes that assure your research is made available to the scientific community without delay
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Personal support during every step of the publication process
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+184,650 citations in Web of Science databases
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Currently strongest OA platform with over 175 million downloads
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This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. 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H. Gulrez, Saphwan Al-Assaf and Glyn O Phillips",authors:[{id:"58120",title:"Prof.",name:"Saphwan",middleName:null,surname:"Al-Assaf",slug:"saphwan-al-assaf",fullName:"Saphwan Al-Assaf"}]}],mostDownloadedChaptersLast30Days:[{id:"35255",title:"Mechanical Transmissions Parameter Modelling",slug:"mechanical-transmissions-parameter-modelling",totalDownloads:7458,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"1982",slug:"mechanical-engineering",title:"Mechanical Engineering",fullTitle:"Mechanical Engineering"},signatures:"Isad Saric, Nedzad Repcic and Adil Muminovic",authors:[{id:"101313",title:"Prof.",name:"Isad",middleName:null,surname:"Saric",slug:"isad-saric",fullName:"Isad Saric"}]},{id:"68505",title:"Research Design and Methodology",slug:"research-design-and-methodology",totalDownloads:25181,totalCrossrefCites:9,totalDimensionsCites:18,abstract:"There are a number of approaches used in this research method design. The purpose of this chapter is to design the methodology of the research approach through mixed types of research techniques. The research approach also supports the researcher on how to come across the research result findings. In this chapter, the general design of the research and the methods used for data collection are explained in detail. It includes three main parts. The first part gives a highlight about the dissertation design. The second part discusses about qualitative and quantitative data collection methods. The last part illustrates the general research framework. The purpose of this section is to indicate how the research was conducted throughout the study periods.",book:{id:"8511",slug:"cyberspace",title:"Cyberspace",fullTitle:"Cyberspace"},signatures:"Kassu Jilcha Sileyew",authors:[{id:"292841",title:"Ph.D.",name:"Kassu",middleName:null,surname:"Jilcha Sileyew",slug:"kassu-jilcha-sileyew",fullName:"Kassu Jilcha Sileyew"}]},{id:"67558",title:"Polymerase Chain Reaction (PCR): Principle and Applications",slug:"polymerase-chain-reaction-pcr-principle-and-applications",totalDownloads:10685,totalCrossrefCites:8,totalDimensionsCites:18,abstract:"The characterization of the diversity of species living within ecosystems is of major scientific interest to understand the functioning of these ecosystems. It is also becoming a societal issue since it is necessary to implement the conservation or even the restoration of biodiversity. Historically, species have been described and characterized on the basis of morphological criteria, which are closely linked by environmental conditions or which find their limits especially in groups where they are difficult to access, as is the case for many species of microorganisms. The need to understand the molecular mechanisms in species has made the PCR an indispensable tool for understanding the functioning of these biological systems. A number of markers are now available to detect nuclear DNA polymorphisms. In genetic diversity studies, the most frequently used markers are microsatellites. The study of biological complexity is a new frontier that requires high-throughput molecular technology, high speed computer memory, new approaches to data analysis, and the integration of interdisciplinary skills.",book:{id:"7728",slug:"synthetic-biology-new-interdisciplinary-science",title:"Synthetic Biology",fullTitle:"Synthetic Biology - New Interdisciplinary Science"},signatures:"Karim Kadri",authors:[{id:"290766",title:"Dr.",name:"Kadri",middleName:null,surname:"Karim",slug:"kadri-karim",fullName:"Kadri Karim"}]},{id:"62059",title:"Types of HVAC Systems",slug:"types-of-hvac-systems",totalDownloads:12466,totalCrossrefCites:9,totalDimensionsCites:15,abstract:"HVAC systems are milestones of building mechanical systems that provide thermal comfort for occupants accompanied with indoor air quality. HVAC systems can be classified into central and local systems according to multiple zones, location, and distribution. Primary HVAC equipment includes heating equipment, ventilation equipment, and cooling or air-conditioning equipment. Central HVAC systems locate away from buildings in a central equipment room and deliver the conditioned air by a delivery ductwork system. Central HVAC systems contain all-air, air-water, all-water systems. Two systems should be considered as central such as heating and cooling panels and water-source heat pumps. Local HVAC systems can be located inside a conditioned zone or adjacent to it and no requirement for ductwork. Local systems include local heating, local air-conditioning, local ventilation, and split systems.",book:{id:"6807",slug:"hvac-system",title:"HVAC System",fullTitle:"HVAC System"},signatures:"Shaimaa Seyam",authors:[{id:"247650",title:"M.Sc.",name:"Shaimaa",middleName:null,surname:"Seyam",slug:"shaimaa-seyam",fullName:"Shaimaa Seyam"},{id:"257733",title:"MSc.",name:"Shaimaa",middleName:null,surname:"Seyam",slug:"shaimaa-seyam",fullName:"Shaimaa Seyam"},{id:"395618",title:"Dr.",name:"Shaimaa",middleName:null,surname:"Seyam",slug:"shaimaa-seyam",fullName:"Shaimaa Seyam"}]},{id:"70315",title:"Some Basic and Key Issues of Switched-Reluctance Machine Systems",slug:"some-basic-and-key-issues-of-switched-reluctance-machine-systems",totalDownloads:1268,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Although switched-reluctance machine (SRM) possesses many structural advantages and application potential, it is rather difficult to successfully control with high performance being comparable to other machines. Many critical affairs must be properly treated to obtain the improved operating characteristics. This chapter presents the basic and key technologies of switched-reluctance machine in motor and generator operations. The contents in this chapter include: (1) structures and governing equations of SRM; (2) some commonly used SRM converters; (3) estimation of key parameters and performance evaluation of SRM drive; (4) commutation scheme, current control scheme, and speed control scheme of SRM drive; (5) some commonly used front-end converters and their operation controls for SRM drive; (6) reversible and regenerative braking operation controls for SRM drive; (7) some tuning issues for SRM drive; (8) operation control and some tuning issues of switched-reluctance generators; and (9) experimental application exploration for SRM systems—(a) wind generator and microgrid and (b) EV SRM drive.",book:{id:"8899",slug:"modelling-and-control-of-switched-reluctance-machines",title:"Modelling and Control of Switched Reluctance Machines",fullTitle:"Modelling and Control of Switched Reluctance Machines"},signatures:"Chang-Ming Liaw, Min-Ze Lu, Ping-Hong Jhou and Kuan-Yu Chou",authors:[{id:"37616",title:"Prof.",name:"Chang-Ming",middleName:null,surname:"Liaw",slug:"chang-ming-liaw",fullName:"Chang-Ming Liaw"},{id:"306461",title:"Mr.",name:"Min-Ze",middleName:null,surname:"Lu",slug:"min-ze-lu",fullName:"Min-Ze Lu"},{id:"306463",title:"Mr.",name:"Ping-Hong",middleName:null,surname:"Jhou",slug:"ping-hong-jhou",fullName:"Ping-Hong Jhou"},{id:"306464",title:"Mr.",name:"Kuan-Yu",middleName:null,surname:"Chou",slug:"kuan-yu-chou",fullName:"Kuan-Yu Chou"}]}],onlineFirstChaptersFilter:{topicId:"1",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83185",title:"Perspective Chapter: Design and Characterization of Natural and Synthetic Soft Polymeric Materials with Biomimetic 3D Microarchitecture for Tissue Engineering and Medical Applications",slug:"perspective-chapter-design-and-characterization-of-natural-and-synthetic-soft-polymeric-materials-wi",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.106471",abstract:"Continuous work and developments in biomedical materials used in three-dimensional (3D) bioprinting have contributed to significant growth of 3D bioprinting applications in the production of personalized tissue-repairing membrane, skin graft, prostheses, medication delivery system, and 3D tissue engineering and regenerative medicine scaffolds. The design of clinic products and devices focus on new natural and synthetic biomedical materials employed for therapeutic applications in different 3D bioprinting technologies. Design and characterization of natural and synthetic soft polymeric materials with biomimetic 3D microarchitecture were considered. The natural soft polymeric materials would focus on new design bioinspired membranes containing supercritical fluids-decellularized dermal scaffolds for 3D bioprinting potential applications. Synthetic soft polymeric materials would focus on bioinspired polyvinyl alcohol (b-PVA) matrix with structural foam-wall microarchitectures. Characterization, thermal stability, and cell morphology of the b-PVA and the corresponding collagen-modified b-PVA were employed to evaluate their potential tissue engineering applications. Also, the b-PVA materials were conductive to HepG2 cells proliferation, migration, and expression, which might serve as a promising liver cell culture carrier to be used in the biological artificial liver reactor. TGA, DTG, DSC, SEM, and FTIR were employed to build up the effective system identification approach for biomimetic structure, stability, purity, and safety of target soft matrix.",book:{id:"11453",title:"Biomimetics - Bridging the Gap",coverURL:"https://cdn.intechopen.com/books/images_new/11453.jpg"},signatures:"Ching-Cheng Huang and Masashi Shiotsuki"},{id:"83187",title:"Cement-Based Materials in Dentistry",slug:"cement-based-materials-in-dentistry",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.106466",abstract:"Cement-based materials in dentistry have experienced rapid development. In the field of operative dentistry, there are mainly developing calcium silicate cements, which have made it possible to solve previously difficult situations such as perforation of the root-canal system, direct pulp capping, filling and preserving teeth with widely open foramen apicale. These materials are based on the Portland cement. This chapter will describe the development, properties, indications and limitations of these materials. In the field of prosthodnotics, the prosthetic restoration is connected to the remaining tissues with the help of cements. Requirements for such materials and the available options will be described. The choice of suitable cement is based on its properties, requirements (such as moisture control), the material of the restoration (optimal choice can affect and strengthen the material) and the characteristics of the remaining dental tissues (such as the conicity of the prepared tooth). The chemical preparation of the tooth and prosthetic material connected with the individual types of the cements, which are capable to ensure the firm connection leading to the long-term and aesthetic result, will be described.",book:{id:"11471",title:"Advanced Cement-Based Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11471.jpg"},signatures:"Ján Staněk, Basel Elia Azar and Tomáš Fichtel"},{id:"83153",title:"Perspective Chapter: Cryptocurrencies Effectiveness for Nature",slug:"perspective-chapter-cryptocurrencies-effectiveness-for-nature",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.106493",abstract:"The rise of cryptocurrencies based on Blockchain platforms have provided multiple solutions for social and nature projects supported by concerned investors with sustainable development initiatives. Speculation and unclear uses of a cryptocurrency plays a negative role for the projects they claim to support. A positive relationship between coin investors and supported projects must position the coin value on the scale of the community involvement among the coin and project issues, thus placing the project results above speculative moves. Coin nature and social based projects may include a decentralized autonomous organization (DAO), combined with a digital currency to contribute to social and nature improvements. This organization provides a framework for the engagement of investors, beneficiaries, and implementation partners, with results measured by reliable third parties. The potential funding from non fiduciary sources for sustainable development targets may be framed under the fundraising and financial solutions models, addressing the cryptocurrency volatility risks with responsible tokenomics in attention to transaction and regulatory issues. Overall, the more clear are the object and transaction issues of a nature conservation project supported by a currency, the more successful it will be in terms of nature and social improvements and the currency valuation for all parties involved.",book:{id:"11551",title:"Blockchain",coverURL:"https://cdn.intechopen.com/books/images_new/11551.jpg"},signatures:"Luiz Cruz Villares"},{id:"82490",title:"Precision Agriculture for Sustainable Soil and Crop Management",slug:"precision-agriculture-for-sustainable-soil-and-crop-management",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.101759",abstract:"Precision agriculture (PA) transforms traditional practices into a new world of production of agriculture. It uses a range of technologies or diagnostic tools such as global navigation satellite system (GNSS), geographic information systems (GIS), yield monitors, near-infrared reflectance sensing, and remote sensing in collecting and analyzing the in-field spatial variability data, thereby enabling farmers to monitor and make site-specific management decisions for soils and crops. PA technology enables visualization of spatial and temporal variations of production resources and supports spatially varying treatments using variable rate application technologies installed on farm agricultural field machinery. The demand for PA is driven by recognition within-field variability and opportunities for treating areas within a field or production unit differently. PA can be applied to multiple cultural practices including tillage, precision seeding, variable rate fertilizer application, precision irrigation and selective pesticide application; and facilitates other management decisions making, for example, site-specific deep tillage to remove soil compaction. PA technology ensures optimal use of production inputs and contributes to a significant increase in farm profitability. By reducing crop production inputs and managing farmland in an environmentally sensible manner, PA technology plays a vital role in sustainable soil and crop management in modern agriculture.",book:{id:"10952",title:"Soil Science - Emerging Technologies, Global Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10952.jpg"},signatures:"Md. Rayhan Shaheb, Ayesha Sarker and Scott A. Shearer"},{id:"83163",title:"Robust Control Algorithm for Drones",slug:"robust-control-algorithm-for-drones",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.105966",abstract:"Drones, also known as Crewless Aircrafts (CAs), are by far the most multi - level and multi developing technologies of the modern period. This technology has recently found various uses in the transportation area, spanning from traffic monitoring applicability to traffic engineering for overall traffic flow and efficiency improvements. Because of its non-linear characteristics and under-actuated design, the CA seems to be an excellent platform to control systems study. Following a brief overview of the system, the various evolutionary and robust control algorithms were examined, along with their benefits and drawbacks. In this chapter, a mathematical and theoretical model of a CA’s dynamics is derived, using Euler’s and Newton’s laws. The result is a linearized version of the model, from which a linear controller, the Linear Quadratic Regulator (LQR), is generated. Furthermore, the performance of these nonlinear control techniques is compared to that of the LQR. Feedback-linearization controller when implemented in the simulation for the chapter, the results for the same was better than any other algorithm when compared with. The suggested regulatory paradigm of the CA-based monitoring system and analysis study will be the subject of future research, with a particular emphasis on practical applications.",book:{id:"11522",title:"Aeronautics - New Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11522.jpg"},signatures:"Parul Priya and Sushma S. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Rosa María Martínez-Espinosa is a Full Professor of Biochemistry and Molecular Biology at the University of Alicante, Spain, and has been the vice president of International Relations and Development Cooperation at this university since 2010. She created the research group in applied biochemistry in 2017 (https://web.ua.es/en/appbiochem/), and from 1999 to the present has made more than 200 contributions to Spanish and international conferences. Furthermore, she has around seventy-five scientific publications in indexed journals, eighty book chapters, and one patent to her credit. Her research work focuses on microbial metabolism (particularly on extremophile microorganisms), purification and characterization of enzymes with potential industrial and biotechnological applications, protocol optimization for genetically manipulating microorganisms, gene regulation characterization, carotenoid (pigment) production, and design and development of contaminated water and soil bioremediation processes by means of microorganisms. 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He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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(Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}]},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. 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His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"213308",title:"Associate Prof.",name:"Manuel Víctor",middleName:null,surname:"López-González",slug:"manuel-victor-lopez-gonzalez",fullName:"Manuel Víctor López-González",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/213308/images/10301_n.jpg",biography:null,institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}},{id:"169212",title:"Prof.",name:"Pavol",middleName:null,surname:"Svorc",slug:"pavol-svorc",fullName:"Pavol Svorc",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169212/images/system/169212.jpg",biography:"Dr. Pavol Švorc is an Associate Professor, Doctor of the Natural Sciences, Philosophe Doctor. In 1982 he became a Doctor of the Natural Sciences from General Biology, Natural Faculty, Šafarik’s University in Košice. In 1995 he received a PhD. – Physiology and Patophysiology, Natural Faculty Šafarik’s University in Košice. In 2005 he became an Associate Professor from Normal and Patological Physiology, Medical Faculty, Šafarik’s University in Košice. From 1982 to 1983 Dr.Švorc worked as an independent specialist in the local museum in Poprad, Slovakia. In 1983 he started working as a lecturer at the Department of Physiology, Šafarik’s University in Kosice, Slovakia. From\r\n2011 until 2014 he was a Head of the Institute of Physiology and Pathophysiology, Medical Faculty, University of Ostrava, Czech Republic. His research interest includes:\r\nChronobiology of cardiovascular system, respiratory system and autonomic nervous system.",institutionString:"Pavol Josef Safarik University",institution:{name:"University of Pavol Jozef Šafárik",country:{name:"Slovakia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. in Chemistry in July 2000, and his Ph.D. in Physical Chemistry in 2007 from the University of Khartoum, Sudan. In 2009 he joined the Dr. Ron Clarke research group at the School of Chemistry, Faculty of Science, University of Sydney, Australia as a postdoctoral fellow where he worked on the Interaction of ATP with the phosphoenzyme of the Na+, K+-ATPase, and Dual mechanisms of allosteric acceleration of the Na+, K+-ATPase by ATP. He then worked as Assistant Professor at the Department of Chemistry, University of Khartoum, and in 2014 was promoted to Associate Professor ranking. In 2011 he joined the staff of the Chemistry Department at Taif University, Saudi Arabia, where he is currently active as an Assistant Professor. His research interests include:\r\n(1) P-type ATPase Enzyme Kinetics and Mechanisms; (2) Kinetics and Mechanism of Redox Reactions; (3) Autocatalytic reactions; (4) Computational enzyme kinetics; (5) Allosteric acceleration of P-type ATPases by ATP; (6) Exploring of allosteric sites of ATPases and interaction of ATP with ATPases located in the cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, México. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 270 peer-reviewed papers, 32 book chapters, and 4 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:null,institution:null},{id:"318757",title:"Associate Prof.",name:"Irina Alexandrovna",middleName:null,surname:"Savvina",slug:"irina-alexandrovna-savvina",fullName:"Irina Alexandrovna Savvina",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318757/images/18742_n.jpg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"5",type:"subseries",title:"Parasitic Infectious Diseases",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology",scope:"Parasitic diseases have evolved alongside their human hosts. 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