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",isbn:"978-1-83881-111-2",printIsbn:"978-1-83880-992-8",pdfIsbn:"978-1-83881-112-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"acb2875b3bfc189c9881a9b44b6a5184",bookSignature:"Dr. Abdo Abou Jaoudé",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11865.jpg",keywords:"Linear Operators, Normal Operators, Spectral Theorem, Applications, Differential Operators, Integral Operators, Functional Calculus, Complex Variables, Complex Analysis, Theory, Recent Advances, Latest Trends",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 13th 2022",dateEndSecondStepPublish:"May 11th 2022",dateEndThirdStepPublish:"July 10th 2022",dateEndFourthStepPublish:"September 28th 2022",dateEndFifthStepPublish:"November 27th 2022",remainingDaysToSecondStep:"5 days",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Abdo Abou Jaoudé is a pioneering Associate Professor of Mathematics and Statistics at Notre Dame University-Louaizé. He holds two PhDs in Mathematics and Prognostics from the Lebanese University and Aix-Marseille University. His research interests are in the field of mathematics.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"248271",title:"Dr.",name:"Abdo",middleName:null,surname:"Abou Jaoudé",slug:"abdo-abou-jaoude",fullName:"Abdo Abou Jaoudé",profilePictureURL:"https://mts.intechopen.com/storage/users/248271/images/system/248271.jpg",biography:"Abdo Abou Jaoudé has been teaching for many years and has a passion for researching and teaching mathematics. He is currently an Associate Professor of Mathematics and Statistics at Notre Dame University-Louaizé (NDU), Lebanon. He holds a BSc and an MSc in Computer Science from NDU, and three PhDs in Applied Mathematics, Computer Science, and Applied Statistics and Probability, all from Bircham International University through a distance learning program. He also holds two PhDs in Mathematics and Prognostics from the Lebanese University, Lebanon, and Aix-Marseille University, France. Dr. Abou Jaoudé's broad research interests are in the field of applied mathematics. He has published twenty-three international journal articles and six contributions to conference proceedings, in addition to seven books on prognostics, pure and applied mathematics, and computer science.",institutionString:"Notre Dame University - Louaize",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Notre Dame University – Louaize",institutionURL:null,country:{name:"Lebanon"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"15",title:"Mathematics",slug:"mathematics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"252211",firstName:"Sara",lastName:"Debeuc",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/252211/images/7239_n.png",email:"sara.d@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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In about 5–15% of the patients with inflammation limited to the colon, it is difficult to distinguish between UC and Crohn’s colitis [1]. These cases of overlap, previously referred to as indeterminate colitis, are now called
Distinguishing between ulcerative and Crohn’s colitis is important in terms of management and prognosis, since patients with CD have a higher risk of stricture and fistula formation that may predict a more severe disease course, as well as an increased risk of surgical intervention [3]. Surgery (colectomy) may be curative in UC patients not responding to medical therapy, while CD patients undergoing surgical resection of the colon can develop delayed inflammation in other areas of the bowel, therefore, needing closer follow-up.
\nThe exact etiology of IBD is unknown and is probably multifactorial. One of the proposed mechanisms that leads to intestinal inflammation in IBD refers to an aberrant immune response in a genetically susceptible host [2]. This mechanism involves a complex interaction between environmental and microbial factors at the intestinal epithelium of patients with susceptibility genes that might lead to an altered innate and adaptive immune response. Intestinal homeostasis relies on the interactions between environmental factors, the epithelium, and the host immune system [4]. Breakdown of any of these components will disrupt the mucosal immune tolerance and promote inflammation.
\nThe
Defects in the tight junctions of the intestinal epithelial cells and changes in the paracellular permeability will inhibit the epithelium from acting as an effective
Research has also focused on the identification of
Over the past decade, IBD research has focused on the role of genetic and serological markers in the phenotypic presentation of UC and CD. However, since UC and CD have different genetic and serological markers, such markers may also be used in identifying unclassified colitis. This review looks at the evidence behind these biomarkers and their role in different IBD subtypes.
\nThere is no single marker that will determine the subtype of IBD; however, the combination of different serological markers may increase our ability in distinguishing between these subtypes. In patients whom it is difficult to differentiate between UC and CD using the traditional clinical, endoscopic, and histological criteria, serological markers are becoming increasingly helpful [10]. This area of research is rapidly expanding as new antibodies to different microbial antigens and autoantibodies are being discovered [2]. Antibodies to microbial agents include the anti-glycan antibodies, while antibodies to self-antigens include anti-neutrophil cytoplasmic antibodies (pANCA) and antibodies against exocrine pancreas (PAB).
\nResearch has produced significant data on anti-
However, more recently new serum biomarkers are being discovered. These biomarkers classify the type of colitis and also play an important role in predicting disease course, risk of complications, and response to treatment. Anti-glycan antibodies are strongly associated with CD, and their presence is also linked to a more severe disease type and risk of disease progression as well as an increased risk for IBD-related surgery [10]. The anti-glycan carbohydrate antibodies include anti-chitobioside IgA (ACCA), anti-laminaribioside IgG antibodies (ALCA), antimannobioside IgG antibodies (AMCA), and more recently, anti-laminarin (anti-L) and anti-chitin (anti-C).
\nThe overall sensitivity of the newer anti-glycan antibodies in CD is low [1]; however, combining different serum biomarkers increases the predictive value for differentiating CD from UC. Being ASCA positive and pANCA negative increases the specificity and positive predictive value for diagnosis of CD compared to ASCA positivity alone [11]. In a study published in 2009 by Seow et al. evaluating more than 800 patients with IBD, it was found that 73% of the CD patients were positive for 1 or more anti-glycan antibodies [12]. In addition, all anti-glycan antibodies were specific for CD and more prevalent in CD rather than in UC.
\nThese findings were confirmed in 2010 by Rieder et al. who also showed a higher prevalence of serum antibodies in CD than in UC [13], gASCA, or the combination of gASCA/pANCA were found to be most accurate for the diagnosis of CD, but using a combination of antibodies improved the differentiation between CD and UC [13].
\nOther antibodies that target microbial antigens include anti-outer membrane porin C (anti-OmpC), anti-Cbir1 flagellin, and anti-I2 antibody [2]. CD patients have an excessive secretion of IgA antibodies against OmpC, an outer membrane porin found in
Flagellin is an antigen present on most motile bacteria in the gut and is highly antigenic [2]. Flagellin CBir1 has been identified as a colitogenic antigen. Anti-CBir1 is more commonly found in CD rather than in UC patients (50–56% prevalence in CD versus less than 6% in UC) [2].
\nAntibodies targeting the exocrine pancreas (PAB) are also highly specific for CD. The autoantigen of PAB in CD is the membrane glycoprotein (GP2) on pancreatic acinar cells [2].
\nA number of antibodies have been identified in IBD, pANCA being most typically associated with UC. Despite this association, the use of antibodies has been limited in clinical use in UC. The combination of ASCA–/pANCA+ results in better diagnostic accuracy for differentiating CD from UC than either test alone. Additionally, CD patients who are pANCA positive may have colonic disease resembling UC-like disease. After resection, UC patients remain pANCA positive unlike CD patients in whom ASCA titres return back to normal [2].
\nThe pANCA staining pattern is not specific to UC and is found in a number of autoimmune diseases and in up to 2.5% of healthy controls. Loss of antigenic response after DNase digestion of neutrophils, however, seems to be a dominant characteristic of UC-specific pANCA and is termed DNase-sensitive pANCA [15].
\nSerum biomarkers may, therefore, be used to help distinguish IBD from other diseases of the gut to identify the type of IBD in those patients who are difficult to classify using the classical clinical, endoscopic, histological, and radiological criteria, and to predict disease severity. The latter is related to both the number of positive serological antibodies present and their levels. There is no role in repeated testing for these biomarkers to assess disease activity [2]. Nor is it useful to predict response to treatment in CD.
\nIn IBD patients with unclassified colitis, about half of these patients will eventually manifest as CD or UC. Usually, these are the patients who have a positive biomarker (ASCA or pANCA). The other half will remain with a diagnosis of unclassified colitis. Most of these patients are negative for both ASCA and pANCA [16]. This is where newer biomarkers might help to further classify the subtype of IBD.
\nBoth anti-laminarin (anti-L) and anti-chitin (anti-C) are associated with more aggressive CD phenotypes. In particular, anti-C has been associated with penetrating and perianal disease [12]. Anti-L appears to be associated with more steroid-dependency but is also useful in improving the differentiation between ulcerative and Crohn’s colitis when used with ASCA and ANCA antibody status [17].
\nBesides differentiating between ulcerative and Crohn’s colitis, serological biomarkers may also help in predicting the clinical course and behavior of the disease. Elevated titres of antimicrobial antibodies makes it more likely for a patient with CD to develop more severe and complicated disease, with an increased risk of requiring IBD-related surgery. The chance of having more severe disease increases with the number of serum biomarkers present and also with increasing titres of these antibodies [2]. Seow et al. have shown that an increasing number of positive antibodies is associated with early CD onset, fistulating and perianal disease, and increased risk for surgery [12]. These findings were confirmed by Rieder et al. who showed that a higher number of anti-glycan antibodies predicts a faster progression toward more severe disease [18]. Anti-GM-CSF antibody also correlates with disease activity and an increased risk of relapses [10].
\nSerological markers such as anti-GP2 and anti-CBir1 may contribute to better stratification of pouchitis in patients with UC undergoing ileal pouch-anal anastomosis (IPAA). A retrospective study published in 2012 by Coukos et al. analyzed ASCA IgG and anti-CBir1 antibodies in patients with UC who underwent IPAA. Both ASCA IgG and anti-CBir1 titres were significantly associated with postoperative IPAA complications. A positive anti-CBir1 test was found to be associated with CD of the pouch and/or fistula formation (
Notwithstanding their role in distinguishing IBD subtypes and predicting IBD phenotypes, serum biomarkers are frequently not useful in diagnosing clinical remission. Their levels remain elevated even in patients who are in endoscopic and histological remission. For example, the level of CBir1 antibody in the serum does not correlate with disease severity and stable CBir1 expression has been found in the serum of CD patients during both active disease and also when in endoscopically proven remission [21].
\nSerum biomarkers are not specific to CD but may also be found to a lesser extent in patients with other disorders of the gastrointestinal tract or in healthy individuals. For example, ASCA and PAB, which are highly specific antibodies in CD, can also be found in patients with coeliac disease, especially prior to commencing a gluten-free diet. Therefore, these serum antibodies are not to be used on their own to diagnose IBD, but are meant to be an extra tool in the accurate diagnosis and management of IBD [2].
\nGut inflammation in IBD is believed to occur secondary to an interaction between the altered immune system of a genetically susceptible individual and environmental factors such as antimicrobial agents. IBD is regarded as a polygenic disorder with multiple susceptibility loci contributing to the overall risk of developing the disease [22]. There are frequently different genetic loci, which are involved in the pathogenesis of UC and CD, and this may be used in distinguishing between Crohn’s and ulcerative colitis.
\nIt may occasionally be difficult to differentiate functional from organic bowel diseases based on the clinical presentation and even more difficult to distinguish CD from UC. In a study published in 2008, von Stein et al. tried to identify genes from mucosal biopsy specimens which could help discriminate between functional disease and IBD and also genes which could distinguish between CD and UC [23]. The group identified seven IBD-specific genes that could help determine IBD type in patients with colitis. These genes were solute carrier (SLC)6A14, SLC26A2, small protein associated with PDZ domain-containing protein 1 (SPAP), regenerating protein IV (RegIV), Vanin-1, matrix metalloproteinase 7 (MMP-7), and growth-related oncogene alpha (GRO-alpha). These genes have been shown to play a role in IBD, be it in inflammation, tissue injury, or carcinogenesis. For example, GRO-alpha is a chemokine that recruits and activates neutrophils at the site of inflammation [24]. Using these seven biomarkers, one could correctly classify UC or CD patients in more than 92% of cases [25].
\nWu et al. also tried to identify genes that are associated with CD, UC, and non-IBD colitis [26]. Genes differentially expressed in the CD patients were related to IFN gamma-inducible TH1 processes (IFITM1, IFITM3, STAT1, and STAT3) and antigen presentation (TAP1, PSME2, and PSMB8).
\nThe role of several genes involved in epithelial defense has been studied as a possible contributing factor to the development of CD [27]. Some of the genes studied confirm a link between defects in the immune response and the role of intracellular bacteria in patients with CD.
\nNucleotide-binding oligomerization domain containing 2 (NOD2) gene is found on chromosome 16 and is one of the earlier genes to be linked to CD. NOD2 variants that alter the structure of the leucine-rich repeat domain of the protein can overactivate nuclear factor NF-kB in monocytes, thereby altering the response of the immune system to microbial pathogens [28]. Polymorphisms in the NOD2 gene have been associated with more complicated disease in CD [29].
\nNOD2 gene polymorphisms may also have implications on drug treatment. Gutierrez et al. studied phagocytic and bactericidal activities in neutrophils of patients with CD. Patients with a NOD2-variant had less phagocytic and bactericidal activities and increased TNFα levels in response to the presence of bacterial DNA [30]. This might have an effect on the management of these patients as they may require more aggressive treatment, with an increased requirement for anti-TNFα agents.
\nHampe et al. were among the first to show a potential role of autophagy in the pathogenesis of CD. The group studied the autophagy-related 16-like 1 (ATG16L1) gene, which encodes a protein that processes intracellular bacteria. A variant of this gene was found in CD but not in UC patients [31]. It supports the role of bacteria in the pathogenesis of CD as the processing of intracellular bacteria would be altered in patients having a variant of the gene.
\nAnother gene involved in autophagy of intracellular pathogens is the immunity-related GTPase family M (IRGM) gene. IRGM is a CD susceptibility gene [32] that does not increase the risk of developing UC [33].
\nThe protein tyrosine phosphatase nonreceptor type 2 (PTPN2) gene is also involved in the autophagy pathway and PTPN2 polymorphisms have also been associated with IBD. The PTPN2 polymorphism rs2542151 appears to be associated with both CD and UC, while polymorphisms rs1893217 and rs7234029 are associated with CD only [34].
\nVariants of the prostaglandin receptor 4 (PTGER4) have been implicated to have a role in CD. In a German cohort of CD patients, Prager et al. found that the variant rs7720838 increased susceptibility to CD but not to UC. Patients with this gene variant were more likely to develop stricturing disease with the risk of stricture formation increasing further if the patient also had NOD2 mutations [35]
\nInterleukin (IL)-23R mutations and their role in CD have been studied extensively. The IL-23 cascade contributes to the differentiation of the T helper (Th) 17 cells, which play an important role in immunoregulation in the gut [25]. Dysregulated Th17 differentiation may occur in CD patients [36, 37].
\nThe rs11209026 SNP in IL23R was found to have a protective effect for IBD. Both CD and UC were associated with IL23R in a study conducted in over 500 Dutch patients with IBD [38]. In another study involving Korean patients with CD, two other polymorphisms (rs1004819 and rs1495465) were significantly associated with CD, and when the genotype was correlated to the disease phenotype, it was found that it was associated with both stricturing and penetrating disease [39].
\nCD and UC may share some gene susceptibility loci but significantly differ at others. While genetically determined defects in the handling of intracellular bacteria (NOD2 and the autophagy genes ATG16L1 and IRGM) are specific to CD, multiple components in the Th17 pathway (IL23R, IL12B, JAK2, STAT3) are associated with both CD and UC [40, 41].
\nNew potential pathogenic pathways for both CD and UC have been demonstrated, initially by genome-wide assocation studies (GWAS) and more recently via imputation and meta-analyses to combine the power of multiple individual GWAS. Meta-analyses of GWAS have shown that CD and UC share the majority of the 163 known genetic risk factors for IBD, although to varying extents, for example, IL23 pathway is more commonly linked to CD rather than to UC despite being strongly associated with both [42].
\nThe major histocompatibility complex (MHC) seems to be one of the notable exceptions to this. In a large cohort of patients with IBD (18,405 Crohn’s disease patients, 14,308 ulcerative colitis patients, and 34,241 controls), it was shown that the MHC region is a significant contributor to disease risk in IBD. However, while the majority of non-MHC susceptibility loci are shared between both UC and CD, most associated HLA alleles have a predominant role in either one or the other, with very few conferring shared IBD risk. Furthermore, whereas both class I and class II HLA variants contribute to disease risk in CD, class II variation seems to have a more important role in UC [43].
\nAltered epithelial barrier function may play a role in the development of UC but not in CD. A number of epithelial barrier genes are in fact specifically associated with ulcerative colitis (OCTN2, ECM1, CDH1, HNF4A, LAMB1, and GNA12). The role of epithelial barrier genes HNF4A, E-cadherin, and laminin was also first discovered by GWAS of a relatively small sample of 2361 white patients of European descent as part of the Wellcome Trust Case Control Consortium 2 [44]. The exact mechanisms by which such defects play a bigger role in the pathogenesis of UC than in CD are still poorly understood.
\nPrimary sclerosing cholangitis (PSC) has long been associated with IBD, especially with UC. Up to 5% of patients with UC have PSC, while up to 3.6% of patients with CD have PSC, mostly those patients with extensive disease [45].
\nHowever, the phenotype of IBD in the context of a patient with both IBD and PSC is different from the IBD phenotype of a patient without PSC. De Vries et al. have recently published a systematical review of the literature to identify the distinctive features of IBD in patients with concomitant PSC [46]. The characteristics and clinical course of IBD in patients with PSC are different, making it distinct from the conventional IBD phenotypes.
\nThe prevalence of IBD in PSC is high, ranging from 46.5 [47] to 98.7% [48]. More than 75% of these patients have UC, followed by CD and unclassified IBD.
\nAlthough the disease course of IBD in PSC is found to be quiescent, pancolitis is observed more frequently, with rates varying from 35 to 95% [49, 50]. Another two characteristics which are more commonly reported in IBD patients with PSC than in conventional IBD are backwash ileitis and rectal sparing [51]. Although the disease activity of Crohn’s is similar in patients with and without PSC, the reported rates of complications like stricturing and penetrating disease are lower in patients with concomitant PSC [52]. On the other hand, patients with IBD and PSC who undergo proctocolectomy with ileal pouch—anal anastomosis (IPAA) have a higher risk of developing pouchitis than IBD patients without PSC [46].
\nThe risk of dysplasia or development of colorectal carcinoma is increased in PSC-IBD. For this reason, guidelines on colorectal cancer surveillance classify patients with IBD-PSC in the high risk category, recommending increased frequency of surveillance colonoscopies. The cumulative 10-year risk varies between studies, but is significantly higher than in IBD patients without PSC. In addition to this, the predominant site of dysplasia or malignancy is different in IBD patients with PSC. It tends to occur in the proximal colon, as opposed to conventional IBD, where right-sided localization is less common [46].
\nPSC-IBD patients have been observed to develop dysplasia or colorectal carcinoma earlier than IBD patients without PSC, where the mean interval between the diagnosis of IBD and the development of dysplasia or colorectal carcinoma is longer [53].
\nPatients who undergo orthotopic liver transplantation for PSC still have high rates of IBD exacerbation despite being on immunosuppressant medication. Up to 51.5% of these patients experience an exacerbation [54].
\nThe etiology of PSC is not clear. It has been shown in genetic studies that it shares risk loci with IBD. It is genetically more similar to UC, which might explain why UC is the predominant IBD phenotype associated with PSC. However, there are also several genetic loci, which are associated with PSC but not with IBD [46]. These differences, together with the characteristic features described above, suggest that PSC-IBD is a phenotype, which is distinct from UC or CD.
\nSerological and genetic markers may play an important role in identifying IBD type in patients with unclassified colitis. Figure 1 summarizes some of the genetic loci and serological markers which can help us classify the type of colitis, and the degree of overlap which exists between CD and UC. These markers may have an important role in patients with unclassified colitis and may be used in these patients to create a risk score for IBD type. Thus, a patient with unclassified colitis who is ASCA+/pANCA− and carries the NOD2 and ATG16L1 polymorphisms has a significantly higher chance of having Crohn’s colitis while patients who are ASCA−/pANCA+ and have polymorphisms in epithelial barrier genes are more likely to have UC.
\nGenetic loci and serological markers, which may be used to distinguish between Crohn’s disease (CD) and ulcerative colitis (UC) in unclassified colitis. (NOD2, nucleotide-binding oligomerization domain-containing protein 2; ATG16L1, autophagy-related 16-like 1; IRGM, immunity-related GTPase family, M; PTGER4, prostaglandin receptor 4; IFN, interferon; TH1, type 1 helper T-cell; IFITM, interferon inducible transmembrane protein; STAT, signal transducer and activator of transcription; SLC, solute carrier; SPAP, small protein associated with PDZ domain-containing protein-1; RegIV, regenerating protein IV; MMP, matrix metalloproteinase; GRO, growth-related oncogene; TH17, T helper 17 cells; IL23R, interleukin 23 receptor gene; JAK2, Janus kinase 2; PTPN2, protein tyrosine phosphatase, nonreceptor type 2; OCT, organic cation transporter; ECM1, extracellular matrix protein 1; CDH1, E-cadherin; HNF, hepatocyte nuclear factor; LAMB1, laminin β1; GNA12, guanine nucleotide binding protein, alpha 12; ASCA, anti-
While there is significant evidence to link these markers to specific disease types, more evidence is needed. Since different gene polymorphisms are commoner in different geographical areas, population-based studies are needed to identify genes in specific populations. We also feel confident that with more research, other different disease-specific antibodies will be discovered. Long-term follow-up of patients with unclassified colitis may also help better characterize this disease and help us create a score based on serum biomarkers, which can predict the disease type in this group of patients.
\nPrecambrian mafic magmatism and its role in the evolution of Earth’s crust has received particular attention of the geoscientists during the last three decades because it has not only been influenced by progressive secular compositional variation and mantle sources/reservoirs but also by onset of plate tectonics. Study of dykes is useful for recognition of Large Igneous Provinces (LIP) and rebuilding of different continents which may have displaced through geological time [1]. All protocontinents of India such as Aravalli-Bundelkhand, Dharwar, Bastar and Singhbhum retain dykes of varied orientations, therefore, these dykes or dyke swarms represent a main thermal episode during the Proterozoic or Precambrain times [2]. Geochemical and isotope studies of these dykes offer an opportunity in understanding the geochemical evolution of mantle through space and time [3, 4].
Singhbhum Craton is a book that records complex geological and tectonic processes from Paleoarchean to Neoproterozoic [5, 6]. Several dykes of mafic to acidic compositions are intruding the Singhbhum Granitoid Complex, which are collectively referred to as the Newer dolerites dykes (NDD) in the geological literature [7, 8]. Being the latest magmatic episode of the Singhbhum Granitoid Complex, Newer dolerite dykes provide the path in understanding the Proterozoic geodynamic evolution of the Singhbhum Craton [9]. The present work contributes in understanding the mantle source characteristics and tectonic setting of the NDD.
Mahanadi Graben and Sukinda thrust borders the Eastern Indian shield in the west and granulite terrain of Eastern Ghats along with recent alluvium surrounds this shield in the south, whereas, Gangetic alluvium and Quaternary sediments of Bengal basin exist in north and east of this shield (Figure 1). The major divisions of this shield includes: Chotanagpur Granite Gneiss Complex, Singhbhum Mobile Belt and Singhbhum Craton. The general geological features of each of the above geological provinces are briefly discussed in the following sections.
Simplified geological map of eastern Indian shield illustrating the three geological provinces viz. Chotanagpur granite gneiss complex (CGGC), Singhbhum Mobile Belt (SMB) and Singhbhum craton (SC). SSZ – Singhbhum shear zone [
Chotanagpur Granite Gneiss Complex (CGCC) exists in West Bengal and Jharkhand states of India and covers an area of about 80,000 km2 (Latitudes 23°00′N to 25°00′N; Longitudes 83°45′E to 87°45′E). It is mostly made of granites, granite-gneisses, migmatites, dolerite dykes and pegmatite, aplite and quartz veins From the structural patterns, worked out in different parts of the CGGC, it is clear that the region has undergone polyphase deformation producing distinctive folds and related linear fabrics [8].
The formations occurring in between the Singhbhum Granitoid Complex (SGC) and CGGC are collectively recognized either as the Singhbhum Mobile Belt (SMB) or Singhbhum Group. The SMB (Figure 2), has been divided into five litho-stratigraphic domains from north to south [11, 12] like (a) volcano-sedimentary belt, (b) Dalma metavolcanic belt, (c) Chaibasa and Dhalbhum Formations, (d) the rocks occurring in the SSZ and (e) Dhanjori and/or the Ongarbira metavolcanic rocks.
Simplified geological map of the Singhbhum craton [
The Singhbhum Craton (SC) records a long history of crustal evolution from Mesoarchaean to Mesoproterozoic. It is an extensive terrain of granite and gneissic complex with subordinate metabasic and minor metasedimentary rocks (Figure 2). Some important geological units are briefed below:
Older Metamorphic Group (OMG) occurs near Champua (Latitudes 22°04′N: Longitudes 85°40′E) and as enclaves in the SGC. This group had experienced amphibolite facies metamorphism and is made of pelitic schists, garnetiferous quartzite, calc-magnesian metasediments and sill like mafic rocks [5]. Goswami et al. [13] and Mishra [14], have dated detrital zircons and recognized an older limit of 3.5Ga age for these supra-crustals. On the bases of Pb/Pb whole rock dating, Moorbath and Taylor [15] has established 3378 ± 98 Ma age for these supra-crustals. This age matches with Sm/Nd (TDM model) ages of 3.41, 3.39 and 3.35 Ga [15]. Sharma et al. [16], however, pointed out that protoliths of OMG amphibolites are 3305 ± 60 Ma old and therefore OMTG which intrude OMG cannot be older than 3300 Ma. The younger 3.40, 3.35 and 3.20 Ga ages have been interpreted as metamorphic events [17, 18].
It has been suggested that SGC (Latitudes 21°00′ and 22°45′ N: Longitudes 85°30′ and 86°30′E) is composed of 12 distinct units that were emplaced in three successive magmatic phases [5]. The K-poor, granodiorite trondhjemite early (phase I) has been dated as 3.25 ± 0.05 Ga [19]. The II and III phases are made of granodiorite that grade to monzogranite and granite and these phases are dated as 3.06 Ga (Pb/Pb whole rock) and 2.9 Ga (Rb/Sr. whole rock) respectively [5]. The other granitic bodies that occur in SC show ages similar to that of SGC, for example, Bonai granites (3369 ± 57 Ma) [20] and Katipada tonalite (3275 ± 81 Ma) [21]. Recent U–Pb zircon studies have revealed that rocks of the SG batholith were emplaced between ~3.45 Ga and ~ 3.32 Ga [22].
BIF is considered to have been deposited in three interconnected basins [5]. These basins are: (i) Noamundi (Latitudes 22°09′N: Longitudes 85°31′E) – Koira (Latitudes 21°54′N: Longitudes 85°15′E) basin of west Singhbhum district and Keonjhar, (ii) Gorumahisani (Latitudes 22°18′30′N: Longitudes 86°17′E) – Badampahar (Latitudes 22°04′N: Longitudes 86°07′E) basin along the eastern border of the Singhbhum Granitoid Complex and (iii) Daitari-Tomka basin in the southern parts of the Singhbhum Craton. In the Noamundi– Koira BIF, rocks are made up of shale, phyllite, the middle formation of banded hematite jasper and an upper formation of magniferous shale, chert, manganese formation and shale. A granite body intruding BIF near Sulaipat has been dated as 3.12 ± 0.01 Ga [23]. Some mafic and ultramafic rocks referred to as Gorumahisani Greenstones are associated with this Gorumahisani-Badampahar BIF sequence [24].
Bonai volcanics show sub-aerial and sub-marine features in the west and east parts of its extension respectively [24, 25]. These volcanics are made of mafic rocks, tuffs and subordinate silica volcanic clastic interbeds. It has been inferred that these volcanics show island arc basalt characteristics [24].
These volcanics are exposed around Noamundi upto Jagannathpur and are younger than BIF of Noamundi-Koira belt [24]. Significantly, NDD are not cutting across the Jagannathpur Suite. It, therefore, appears that it is either equivalent in age or younger than the NDD. Alvi and Raza [26] found these to be calc-alkaline basalts and suggested that these lava flows represent an early arc volcanism. The Jagannathpur lavas have been dated around 1629 ± 30 Ma by K/Ar method [5] and 2250 ± 81 Ma by Pb/Pb whole rock isochron method [27].
It is associated with Gorumahisani-Badampahar BIF along the eastern border of SBGC. The rocks of this volcanic suite are intruded by Kumhardubi (Latitude 22° 17′N: Longitude 86°19′30″) - Dublarbera (Latitude 22°29′30″ N: Longitude 86°17′E) gabbro- anorthosite, Rangamatia (Latitude 22°29′15″N: Longitude 86°17′30″E) Leucotonalite, Katupith (Latitude 22°18′N: Longitude 86°17′30′′E) Leucogranite and NDD swarm.
Recently Kar et al. [28] suggested that the circular shape of Simlipal complex is only a topography controlled rather than an existence of alternate bands of mafic volcanic and quartzites. Further, they suggested that the Simlipal complex overlies the weakly metamorphosed basement heterolith unit (Lulung Formation) which is overlain by Barehipani Formation and Jurunda Formation. Paleoproterozoic age for this complex has been given by Saha [5]. Further, Iyengar et al. [29] suggested 2084 ± 70 Ma age for Similipal complex by following the Rb-Sr whole rock method.
This group exists on the western margin of the SBC and its length is around 100 km with a width of about 12 km. Saha [5] correlated Chaniakpur-Keonjhargarh, Mankarchua and Sarpalli-Kamakhyanagar formations with Kolhan Group. The Singhbhum granite Basement, Dongoaposi (Jagannathpur) lavas and the Iron Group surround Kolhan basin on the NE, S-SE and west respectively [30]. The Kolhan shales north of Hat Gamaria are intruded by three parallel sills of the NDD. South west of Jagannathpur, flat lying Kolhan shales overlie the Jagannathpur lava.
NDD have experienced low grade regional metamorphism in the vicinity of Singhbhum Shear Zone, however they are fresh to least effected in the western and central parts of the Singhbhum Granitiod Complex. NNE–SSW trending ultramafic-mafic dyke exposed near Keshargaria is medium to coarse grained rock with green to dark green color. The ultramafic dykes which consist of olivine (25–52%) and pyroxenes (45–65%) are present. Mafic dykes are mainly massive, sometimes coarse grained and their color varies from black to greenish gray. The essential constituents of dolerite type of dykes includes pyroxenes, plagioclases and quartz with little amphiboles. Clinopyroxene is mainly augite in the form of euhedral to subhedral prismatic phenocrysts and also as granular aggregates in the groundmass. Rarely, clinopyroxene shows alteration to pale-green amphibole and/or biotite around the grain boundaries. Quartz (0.5 to 3%) is present as subhedral to anhedral crystals. Accessory minerals are opaques, apatite, and rutile. Opaque minerals (0.5 to 5%) include magnetite and Cr-Spinel. Norite samples consist dominantly orthopyroxene (hypersthene) and plagioclase (labradorite) together with subordinate diopsidic augite and small amounts of quartz. In Quartz dolerites relatively greater proportion of anhedral quartz is noticed. The major constituents in quartz dolerite are calcic plagioclase, clinopyroxene (diopside-augite) and subordinate amount of orthopyroxene (hypersthene, enstatite). Coarse grained gabbroic variety of the NDD is mostly coarse grained dark colored. Under microscope, they show overall hypidiomorphic texture with local development of subophitic texture. They show subhedral laths of labradorite plagioclase and augite. Orthopyroxene is rarely found within this petrographic variant.
While observing geochemical characteristics, NDD have been classified as (i) ultramafic dykes {having MgO >30.0 wt. %, SiO2 < 45.0 wt. %, Al2O3 < 5.0 wt. % and alkalies <1.0 wt. %; (ii) Group I dykes {having MgO 12–22 wt. %, SiO2 45–53 wt. %, Al2O3 < 11.0% and total alkalies <3.0%; (iii) Group II dykes {having MgO 7.0–19.0 wt.%, SiO2 51–60 wt. %, Al2O3 10–12 wt. % and alkalies 1.0–3.50 wt. %; (iv) Group III {having MgO 6.0–12 wt. %, SiO2 51.0–70.0 wt. %, Al2O3 10.0–12.5 wt. % and total alkalies 2.0–4.5 wt. %. Group I dykes contain lower MgO and MnO and higher SiO2, TiO2, Al2O3, P2O5 and alkalies as compared to Ultramafic dykes. Group II contains high TiO2, Fe2O3, MgO and P2O5 contents and lower SiO2 and Alkalies relative to group III dykes. In Total Alkali-Silica relationships the NDD show chemical variation from ultramafic to dacite through basalt and basaltic andesite (Figure not shown). Some samples show chemical features like MgO > 8%, SiO2 > 52%, TiO2 ≤ 0.5% and CaO/Al2O3 < 1 similar to that found in boninitic rocks [31, 32, 33, 34].
In under investigated samples Mg# (Mg # = molar 100 Mg/Mg + Fetotal) show variation like 89–85, 79–64, 80–43 and 74–49 in ultramafic dykes, group I, II and III dykes respectively. Such a change in Mg# is consistent with the fractional crystallization of ferromagnesian minerals [35]. The presence of normative quartz content in studied dolerite samples (excluding ultramafic samples) having Mg# >70 may indicate their derivation from multiple parental magmas. Mir and Alvi, [36] have suggested more investigation in terms of isotope geochemistry and radiometric data of ultramafic dykes from Keshergarya village, Singhbhum craton. They suspect their relationship with the mafic members of the NDD. Tholeiite and calc-alkaline trends are commonly based on AFM ternary plot (A = Na2O + K2O, FeO* = total iron as FeO, and M = MgO) [37]. In AFM diagram the NDD show tholeiitic trend. Ultramafic dykes concentrate towards MgO corner of AFM diagram (Figure 3).
K2O + Na2O-Fe2O3t-MgO (AFM) diagram showing theoleiitic trend of NDD. Field lines are after Kuno [
During the partial melting or fractional crystallization the transitional elements like Nickel (Ni) and Cobalt (Co) are compatible with olivine whereas Scandium (Sc), Chromium (Cr) and Vanadium (V) are compatible with clinopyroxene [39], hence these elements are important in petrogenetic studies of basic rocks. These elements are useful to demarcate the primary nature of magma as it has been noted that primary mid ocean ridge basalt (MORB) magmas retain high concentration of Ni (> 250–400 ppm), Cr (> 600 ppm) and Mg # > 70 [35]. Mg#, Ni & Cr varies like {(85–89, 150–304 & 560–2458), (64–79, 45–145 & 255–733), (43–80, 9–73 & 31–524), (49–74, 17–43 & 42–226)} respectively in concern ultramafic dykes, group I, II and III mafic dykes. Such geochemical observations infer that the samples with low Mg #, Cr and Ni values may have evolved through fractional crystallization of olivine and pyroxene [35]. Further, it has been suggested that some dyke samples having similar Mg# with distinct Ni and Cr contents and some samples having distinct Mg# with similar Ni and Cr contents indicates that either the diverse extents of partial melting of the same source or heterogeneous mantle sources are responsible for the generation of different phases of the Newer dolerite dykes. Ti/V values ranging from 20 to 50 indicates the low oxygen fugacity (ƒO2) i.e. reduced condition of magma generation like MORB setting whereas Ti/V values ranging from 10 to 20 are markers of high ƒO2 i.e. oxidizing condition of magma generation like subduction zones or supra-subduction zones settings [40]. In concern Newer dolerite dykes, Ti/V values range from 14 to 30, 9–29, 10–34 and 14–32 in ultramafic dykes, group I, II and III dykes respectively which indicates generation of melts for these dykes had occurred under varied oxidizing conditions.
Mafic intrusions in subduction environments are important for deciphering interaction between subduction slabs and mantle. Such interactions usually result in the mantle wedge being enriched in LILE by introduction of fluids and /melts from the converging lithosphere [41]. Both fluids and melts can be introduced at different depths above a subduction zone [41]. Thus, mafic rocks across subduction zone environments may record variable degrees of mantle source modification by slab derived components [41].
The studied NDD have low K/Rb ratios up to 320 perhaps suggesting the source region of the Newer Dolerites experienced fluid modification [41, 42]. The ratios of elements such as Barium (Ba), Thorium (Th), Zirconium (Zr) and Niobium (Nb) are useful to know about the subduction zone related metasomatism of mantle, hence the values of Ba/Th, Ba/Zr & Ba/Nb in ultramafic dykes, group I, II and III dykes range like {(59–197, 3–6 & 38–119), (35–365; 1–5 & 18–195), (34–231, 1–6 & 10–76) and (37–228, 2–14 & 20–106)} respectively. Such values are higher than that of the average values of the continental crust which in turn points towards the subduction zone related metasomatism of mantle source of these rocks [42]. Two alternative processes could explain the negative Nb anomaly (Figure 4) observed in the NDD: (i) metasomatic enrichment of lithospheric mantle [44] and (ii) chemical interaction between lithospheric mantle and asthenosphere-derived magma having incompatible elements but little Nb [45]. However, high La/Nb and La/Ta of Newer dolerite dykes supports the metasomatic enrichment of lithospheric mantle as a reason for Nb anomalies. Hence, the negative anomalies of Nb and Ti on primitive mantle normalized patterns (Figure 4) [42], abundance of light rare earth elements (LREE) (Figure not shown), nearly flat sub-parallel pattern of heavy rare earth elements (HREE) (Figure not shown), chondrite normalized ratio of Lanthanum to Ytterbium (La/YbN < 12.0) and chondrite normalized ratio of Lanthanum to Samarium (La/SmN < 4.0) of concern NDD supports their affiliation with arc or subduction zone setting [46].
Primitive mantle normalized multi-element spider diagram of NDD. Normalized values are after Sun and McDonald [
The petrogenesis of mantle derived magmatic rocks can commonly be traced by their geochemical and isotopic data. The mafic magmatic activity in the form of dykes at intervals throughout the Proterozoic provides a useful window to monitor mantle evolution [47, 48].
From the mentioned geochemical characteristics, it may be inferred that the NDD having Mg# <60 are evolved members that have been formed through fractional crystallization of Mg-rich minerals like olivine and/or pyroxene [49]. On TiO2 vs. Al2O3/TiO2 (Figure 5a) and CaO/TiO2 diagrams (Figure 5b) NDD plot in MORB, low TiO2 boninite & high-Mg andesite fields which suggests the compatibility of Ti and retention of Al and Ca in residual phases like pyroxenes, garnet, plagioclase and spinel [50]. Further, these relationships indicate that low TiO2 samples were derived from relatively more hydrously fractionated magmas and high TiO2 samples were derived from least hydrously fractionated magmas [51].
(a) TiO2 vs. Al2O3/TiO2 and (b) TiO2 vs. CaO/TiO2 binary diagrams for NDD. HMA-high Mg Andesites and MORB-Mid Ocean ridge basalts.
Fractional crystallization associated with crustal contamination (AFC) is an important process during magma evolution that may modify both elemental and isotopic compositions [52]. As we know that the concentration of Rubidium (Rb), Barium (Ba), Potassium (K), Sodium (Na) etc. is rich in crustal materials whereas P2O5 and TiO2 is poor in these materials. Hence, any crustal contamination of mafic magma changes the primary geochemistry of magma accordingly [41]. However, in concern samples the low content and range of K2O and NaO2 are indications of least crustal contamination in these rocks. In addition to this, the ratio of Cerium to Lead (Ce/Pb) and Niobium to Uranium (Nb/U) are not changed due to partial melting, hence, these ratios can be applied to know about the effects of alteration or crustal contamination of mafic rocks. In concern samples these ratios are higher than that of upper continental crust (Ce/Pb = 3.2) and (Nb/U = 9) [53]. Therefore, it is suggested that the investigated NDD have least or no contamination of crustal materials.
Trace element ratios, such as La/Yb, Th/Yb, Ba/La and La/Nb are widely used to identify the metasomatic agents and estimate the flux from the subducted slab [54]. All these ratios in case of NDD imply varying inputs of sediment and fluid components from the subducting slab in their formation.
The high (La/Yb)N and (Gd/Yb)N in combination with relatively low HREE abundance of the NDD suggest that they may have formed by low degrees of partial melting of a garnet bearing source. Asthenospheric or deep or plume and lithospheric or shallow or non-plume derived mafic melts or basalts can be differentiated or evaluated by geochemical ratios like Lanthanum (La) /Tantalum (Ta) and La/Nb. Thompson and Morrison [55] suggested that values of La/Ta =10–12 and La/Ta >30 indicates that basaltic rocks may have been derived from asthenospheric mantle and lithospheric mantle respectively. Further, Wang et al. [56] used La/Nb ratio to discriminate asthenospheric mantle and lithospheric mantle sources. They suggested La/Nb <1.5 for asthenospheric mantle derived mafic rocks and La/Nb >1.5 for lithospheric mantle derived mafic rocks. In majority of NDD it has been seen that La/Ta is greater than 30 and La/Nb is greater than 1.5 that reveals their derivation may be from lithospheric mantle source. Moreover, on primitive mantle-normalized multi-element diagram (Figure 4), NDD show patterns differed from that of normal mid ocean ridge basalts, enriched mid ocean ridge basalts, ocean island basalts and continental lithospheric mantle and show depletion of Ba, Nb, Sr., P, Ti and richness of Zr. Such geochemical characteristics are similar to that found in arc or back-arc extension basalts [57, 58].
Keeping in view the importance of dykes or dyke swarms in identification of large igneous provinces, reconstruction of continents, continental rifting and continental-continental collision events [59], the geochemical studies on NDD may have potential in understanding the geodynamic evolution of Singhbhum craton in Precambrian times. The association of mafic dykes with the initiation of sedimentary basins and their geochemistry retaining long term memories of subduction processes in the lithosphere mantle are too well known [60]. Origin of NDD has been either related to arc/back-arc tectonic setting i.e. non-plume source [42, 61, 62, 63, 64, 65, 66] or plume source [5, 67]. In addition, Boss [68] suggested both depleted and enriched mantle source for Newer dolerite dykes. However, mantle plume model faces some issues in evaluation of origin of the NDD due to following reasons (i) age of NDD varying from 2800 to 1000 Ma [5, 69, 70] suggests that it is hard to tap a uniform magma source for such a long time interval, (ii) absence of large scale mafic lavas in Singhbhum craton having intraplate setting/geochemistry and (iii) further, the occurrence of voluminous hydrous lithospheric mantle across the cratons developed during the Archaean (~3 Ga) and its role in the Proterozoic magmas [48].
Reported age of newer dolerite dykes vary from 900 Ma to 2800 Ma and traverse a number of rock types in some regular sets like NNE–SSW and NW-SE trends. Variations in major elements, particularly SiO2, Al2O3, CaO, TiO2 contents, and CaO/TiO2 and Al2O3/TiO2 ratios in these dykes indicates that their Ca and Al are held in the residual mantle phases such as clinopyroxene, plagioclase, spinal and garnet. The overall low Mg #, Cr and Ni values in studied NDD indicate their evolution through fractional crystallization of olivine and pyroxene. A few dyke samples having similar Mg# with distinct Ni and Cr contents and some samples having distinct Mg# with similar Ni and Cr contents indicates that either the diverse extents of partial melting of the same source or heterogeneous mantle sources are responsible for the generation of different phases of the Newer dolerite dykes. In studied NDD low content and narrow range of K2O and NaO2 in addition to higher values of Ce/Pb and Nb/U than that of upper continental crust are indications of least crustal contamination in these rocks.
Values of Ba/Th, Ba/Zr & Ba/Nb in NDD are higher than that of the average values of the continental crust which in turn points towards the subduction zone related metasomatism of mantle source of these rocks. Further, the enriched LREE and flat sub-parallel pattern of HREE along with La/YbN <12.0 and La/SmN <4.0 of concern NDD supports their affiliation with arc or subduction zone setting. Moreover, their primitive mantle-normalized multi-element patterns differed from that of normal mid ocean ridge basalts, enriched mid ocean ridge basalts, ocean island basalts and continental lithospheric mantle and show depletion of Ba, Nb, Sr., P, Ti and richness of Zr. Such geochemical characteristics are similar to that found in arc or back-arc extension basalts.
Author is sincerely thankful to the Director, Leh Campus Taru, University of Ladakh for providing facilities in preparation of this book chapter. Author pays thanks to Dr. Malik Zubair A. and Dr. Farooq A. Dar for their valuable suggestions during write up of this book chapter. Constructive comments and valuable suggestions from anonymous reviewers are duly acknowledged.
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In recent years hybrid heterostructures are getting popularity to implement these SPR biosensors for their superior sensing capability. This chapter demonstrates the details of SPR technology with two recently studied prism-based hybrid heterostructures. These heterostructures are made up of conventional SPR biosensors with two additional layers of recently invented transition metal dichalcogenides, platinum di-selenide (PtSe2), and highly sensitive 2D material, tungsten di-sulfide (WS2). Angular interrogation method is discussed to investigate the sensing capabilities of the sensors which prove the superiority of the Ag-PtSe2-WS2 structure. The sensing capability of this structure has been found at least 1.67 times higher than that of the conventional non-hybrid structures, respectively, with comparable FOM and QF. A comparison table has been provided at the end of this chapter which also shows the impressive performance of the hybrid heterostructures for SPR biosensors. Proper demonstration with a suitable example of this chapter will emphasize the potential use of hybrid heterostructure based SPR biosensors in prospective medical diagnostics and biomedical detection applications.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Md. Shamim Anower, Md. Mahabubur Rahman and M. Saifur Rahman",authors:[{id:"328464",title:"Prof.",name:"Md. Shamim",middleName:null,surname:"Anower",slug:"md.-shamim-anower",fullName:"Md. Shamim Anower"},{id:"328466",title:"Mr.",name:"Md. Mahabubur",middleName:null,surname:"Rahman",slug:"md.-mahabubur-rahman",fullName:"Md. Mahabubur Rahman"},{id:"328467",title:"Mr.",name:"M. Saifur",middleName:null,surname:"Rahman",slug:"m.-saifur-rahman",fullName:"M. Saifur Rahman"}]},{id:"73399",doi:"10.5772/intechopen.93931",title:"Ultra-Precise MEMS Based Bio-Sensors",slug:"ultra-precise-mems-based-bio-sensors",totalDownloads:307,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"This chapter evaluated the state-of-the art MEMS sensors used for bio sensing applications. A new class of resonant micro sensor is studied. A sensor structure based on the array of weakly coupled resonators is presented. It is shown that due to the weak coupling employed between the resonators in an array manifest ultra-high sensitivity of the output to the added analytes/biomolecules. Due to the highly-precise output of such bio-sensors, minimum detectable mass in the range of sub-actogram is also possible using such MEMS sensors. Analytical modeling of such micro biosensors is presented in this chapter to understand the key performance parameters. Furthermore, role of these new classes of MEMS resonant biosensors operating at ambient temperature and/or pressure is also discussed.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Vinayak Pachkawade",authors:[{id:"326380",title:"Dr.",name:"Vinayak",middleName:null,surname:"Pachkawade",slug:"vinayak-pachkawade",fullName:"Vinayak Pachkawade"}]},{id:"73990",doi:"10.5772/intechopen.94451",title:"Advanced Materials and Assembly Strategies for Wearable Biosensors: A Review",slug:"advanced-materials-and-assembly-strategies-for-wearable-biosensors-a-review",totalDownloads:541,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Recent technological advances of soft functional materials and their assembly into wearable (i.e., on-skin) biosensors lead to the development of ground-breaking biomedical applications ranging from wearable health monitoring to drug delivery and to human-robot interactions. These wearable biosensors are capable of unobtrusively interfacing with the human skin and enabling long-term reliable monitoring of clinically useful biosignals associated with health and other conditions affecting well-being. Scalable assembly of diverse wearable biosensors has been realized through the elaborate combination of intrinsically stretchable materials including organic polymers or/and low-dimensional inorganic nanomaterials. In this Chapter, we review various types of wearable biosensors within the context of human health monitoring with a focus of their constituent materials, mechanics designs, and large-scale assembly strategies. In addition, we discuss the current challenges and potential future research directions at the end of this chapter.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Eun Kwang Lee, Hocheon Yoo and Chi Hwan Lee",authors:[{id:"325300",title:"Assistant Prof.",name:"Chi Hwan",middleName:null,surname:"Lee",slug:"chi-hwan-lee",fullName:"Chi Hwan Lee"},{id:"325301",title:"Dr.",name:"Eun Kwang",middleName:null,surname:"Lee",slug:"eun-kwang-lee",fullName:"Eun Kwang Lee"},{id:"333243",title:"Prof.",name:"Hocheon",middleName:null,surname:"Yoo",slug:"hocheon-yoo",fullName:"Hocheon Yoo"}]},{id:"74301",doi:"10.5772/intechopen.95050",title:"Theranostic Microneedle Devices: Innovative Biosensing and Transdermal Drugs Administration",slug:"theranostic-microneedle-devices-innovative-biosensing-and-transdermal-drugs-administration",totalDownloads:453,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Biosensing systems based on microneedles can overcome the stratum corneum of the skin, i. e. the outer natural barrier of the human body, without any pain and detect the target analytes directly in the interstitial fluid. Moreover, microneedle-based devices (MNDs) can combine diagnostic sensing and therapeutic administration of drugs in one single tool. From this point of view, more than a painless door to the human body, a MND represents the a perfect example of theranostic instrument, since a single device could quantify the real value of a relevant biomolecule, such as glucose, and accurately deliver a drug, the insulin, if needed. MNDs could be integrated on printed circuit boards, flexible electronics and microfluidic channels, thus allowing a continuous monitoring of the physiological parameters with very low invasiveness, together with sustained and localized administration of drugs. MNDs can be designed for very specific applications, from the detection of skin cancer to the monitoring of metabolic pathways. Moreover, several fabrication approaches have been introduced, from laboratories to large-scale production. Finally MNDs can be properly functionalized to enhance analytical performances.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Principia Dardano, Mario Battisti, Selene De Martino, Ilaria Rea, Bruno Miranda, Luigi Nicolais and Luca De Stefano",authors:[{id:"326612",title:"Dr.",name:"Principia",middleName:null,surname:"Dardano",slug:"principia-dardano",fullName:"Principia Dardano"},{id:"336208",title:"Dr.",name:"Luca",middleName:null,surname:"De Stefano",slug:"luca-de-stefano",fullName:"Luca De Stefano"},{id:"336209",title:"Dr.",name:"Ilaria",middleName:null,surname:"Rea",slug:"ilaria-rea",fullName:"Ilaria Rea"},{id:"336210",title:"Dr.",name:"Mario",middleName:null,surname:"Battisti",slug:"mario-battisti",fullName:"Mario Battisti"},{id:"336211",title:"Dr.",name:"Selene",middleName:null,surname:"De Martino",slug:"selene-de-martino",fullName:"Selene De Martino"},{id:"336212",title:"Prof.",name:"Luigi",middleName:null,surname:"Nicolais",slug:"luigi-nicolais",fullName:"Luigi Nicolais"},{id:"336213",title:"Dr.",name:"Bruno",middleName:null,surname:"Miranda",slug:"bruno-miranda",fullName:"Bruno Miranda"}]},{id:"74225",doi:"10.5772/intechopen.94248",title:"Advanced Biosensing towards Real-Time Imaging of Protein Secretion from Single Cells",slug:"advanced-biosensing-towards-real-time-imaging-of-protein-secretion-from-single-cells",totalDownloads:443,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"Protein secretion of cells plays a vital role in intercellular communication. The abnormality and dysfunction of cellular protein secretion are associated with various physiological disorders, such as malignant proliferation of cells, aberrant immune function, and bone marrow failure. The heterogeneity of protein secretion exists not only between varying populations of cells, but also in the same phenotype of cells. Therefore, characterization of protein secretion from single cell contributes not only to the understanding of intercellular communication in immune effector, carcinogenesis and metastasis, but also to the development and improvement of diagnosis and therapy of relative diseases. In spite of abundant highly sensitive methods that have been developed for the detection of secreted proteins, majority of them fall short in providing sufficient spatial and temporal resolution for comprehensive profiling of protein secretion from single cells. The real-time imaging techniques allow rapid acquisition and manipulation of analyte information on a 2D plane, providing high spatiotemporal resolution. Here, we summarize recent advances in real-time imaging of secretory proteins from single cell, including label-free and labelling techniques, shedding light on the development of simple yet powerful methodology for real-time imaging of single-cell protein secretion.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Lang Zhou, Pengyu Chen and Aleksandr Simonian",authors:[{id:"324950",title:"Prof.",name:"Alex",middleName:null,surname:"Simonian",slug:"alex-simonian",fullName:"Alex Simonian"},{id:"324951",title:"Dr.",name:"Lang",middleName:null,surname:"Zhou",slug:"lang-zhou",fullName:"Lang Zhou"},{id:"324981",title:"Prof.",name:"Pengyu",middleName:null,surname:"Chen",slug:"pengyu-chen",fullName:"Pengyu Chen"}]}],mostDownloadedChaptersLast30Days:[{id:"74457",title:"Hybrid Heterostructures for SPR Biosensor",slug:"hybrid-heterostructures-for-spr-biosensor",totalDownloads:391,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"Surface plasmon resonance (SPR) based biosensors have been enormously studied in the last decade for their better sensitivity. In recent years hybrid heterostructures are getting popularity to implement these SPR biosensors for their superior sensing capability. This chapter demonstrates the details of SPR technology with two recently studied prism-based hybrid heterostructures. These heterostructures are made up of conventional SPR biosensors with two additional layers of recently invented transition metal dichalcogenides, platinum di-selenide (PtSe2), and highly sensitive 2D material, tungsten di-sulfide (WS2). Angular interrogation method is discussed to investigate the sensing capabilities of the sensors which prove the superiority of the Ag-PtSe2-WS2 structure. The sensing capability of this structure has been found at least 1.67 times higher than that of the conventional non-hybrid structures, respectively, with comparable FOM and QF. A comparison table has been provided at the end of this chapter which also shows the impressive performance of the hybrid heterostructures for SPR biosensors. Proper demonstration with a suitable example of this chapter will emphasize the potential use of hybrid heterostructure based SPR biosensors in prospective medical diagnostics and biomedical detection applications.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Md. Shamim Anower, Md. Mahabubur Rahman and M. Saifur Rahman",authors:[{id:"328464",title:"Prof.",name:"Md. Shamim",middleName:null,surname:"Anower",slug:"md.-shamim-anower",fullName:"Md. Shamim Anower"},{id:"328466",title:"Mr.",name:"Md. Mahabubur",middleName:null,surname:"Rahman",slug:"md.-mahabubur-rahman",fullName:"Md. Mahabubur Rahman"},{id:"328467",title:"Mr.",name:"M. Saifur",middleName:null,surname:"Rahman",slug:"m.-saifur-rahman",fullName:"M. Saifur Rahman"}]},{id:"74301",title:"Theranostic Microneedle Devices: Innovative Biosensing and Transdermal Drugs Administration",slug:"theranostic-microneedle-devices-innovative-biosensing-and-transdermal-drugs-administration",totalDownloads:457,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Biosensing systems based on microneedles can overcome the stratum corneum of the skin, i. e. the outer natural barrier of the human body, without any pain and detect the target analytes directly in the interstitial fluid. Moreover, microneedle-based devices (MNDs) can combine diagnostic sensing and therapeutic administration of drugs in one single tool. From this point of view, more than a painless door to the human body, a MND represents the a perfect example of theranostic instrument, since a single device could quantify the real value of a relevant biomolecule, such as glucose, and accurately deliver a drug, the insulin, if needed. MNDs could be integrated on printed circuit boards, flexible electronics and microfluidic channels, thus allowing a continuous monitoring of the physiological parameters with very low invasiveness, together with sustained and localized administration of drugs. MNDs can be designed for very specific applications, from the detection of skin cancer to the monitoring of metabolic pathways. Moreover, several fabrication approaches have been introduced, from laboratories to large-scale production. Finally MNDs can be properly functionalized to enhance analytical performances.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Principia Dardano, Mario Battisti, Selene De Martino, Ilaria Rea, Bruno Miranda, Luigi Nicolais and Luca De Stefano",authors:[{id:"326612",title:"Dr.",name:"Principia",middleName:null,surname:"Dardano",slug:"principia-dardano",fullName:"Principia Dardano"},{id:"336208",title:"Dr.",name:"Luca",middleName:null,surname:"De Stefano",slug:"luca-de-stefano",fullName:"Luca De Stefano"},{id:"336209",title:"Dr.",name:"Ilaria",middleName:null,surname:"Rea",slug:"ilaria-rea",fullName:"Ilaria Rea"},{id:"336210",title:"Dr.",name:"Mario",middleName:null,surname:"Battisti",slug:"mario-battisti",fullName:"Mario Battisti"},{id:"336211",title:"Dr.",name:"Selene",middleName:null,surname:"De Martino",slug:"selene-de-martino",fullName:"Selene De Martino"},{id:"336212",title:"Prof.",name:"Luigi",middleName:null,surname:"Nicolais",slug:"luigi-nicolais",fullName:"Luigi Nicolais"},{id:"336213",title:"Dr.",name:"Bruno",middleName:null,surname:"Miranda",slug:"bruno-miranda",fullName:"Bruno Miranda"}]},{id:"73454",title:"Control Strategy for Underactuated Multi-Fingered Robot Hand Movement Using Electromyography Signal with Wearable Myo Armband",slug:"control-strategy-for-underactuated-multi-fingered-robot-hand-movement-using-electromyography-signal-",totalDownloads:354,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The main goal of this research is to develop a control strategy for an underactuated robotic hand, based on surface electromyography (sEMG) signal obtained from a wireless Myo gesture armband, to distinguish six, several hand movements. The pattern recognition system is employed to analyze these gestures and consists of three main parts: segmentation, feature extraction, and classification. A series of 150 trials is carried out for each movement and it is established which was most suitable for electromyography signals that can be later used in recognition systems. A backpropagation neural network was used as a classifier. The architecture has a hidden network and six output layers. The number of neurons of the hidden network (20) was determined based on the performance in training progress. The proposed system is tested on datasets extracted from five healthy subjects. A great accuracy (94.94% correct assessment). between the experimentally values and those predicted by the artificial neural network (ANN) was achieved. In addition, kinematic analysis of the proposed underactuated hand has been carried out to verify the motion range of the joints. Simulations and experiments are carried out to verify the effectiveness of the proposed fingers mechanism and the hand prosthesis to generate grasp or postures.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Ruthber Rodríguez Serrezuela, Roberto Sagaro Zamora and Enrique Marañón Reyes",authors:[{id:"243806",title:"M.Sc.",name:"Ruthber",middleName:null,surname:"Rodriguez",slug:"ruthber-rodriguez",fullName:"Ruthber Rodriguez"},{id:"270448",title:"Prof.",name:"Enrique",middleName:null,surname:"Marañón",slug:"enrique-maranon",fullName:"Enrique Marañón"},{id:"325023",title:"Prof.",name:"Roberto",middleName:null,surname:"Sagaro Zamora",slug:"roberto-sagaro-zamora",fullName:"Roberto Sagaro Zamora"}]},{id:"74584",title:"Electrochemical Response of Cells Using Bioactive Plant Isolates",slug:"electrochemical-response-of-cells-using-bioactive-plant-isolates",totalDownloads:283,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Traditional herbal medical practices continue to be part of the healthcare needs of the world especially residents of sub-Sahara Africa (sSA). However, the mechanism of action of the plant metabolites to elicit their potency continue to be a mystery due to the lack of standardized methods. The mechanism of plant bioactive compounds to cause cell death is gradually being linked to membrane polarization and depolarization behaviour. The current work seeks to probe the electrochemical response of model cells using bioactive compounds captured in bio-zeolites or membrane mimetics. The voltage and current fluctuations emanating from such studies will establish a correlation between cell death and membrane depolarization. It will be a useful biological interface sensing material with the potential to identify plant metabolites that can selectively detect and destroy diseased cells. Several model membranes have already been developed for biomedical applications and this new paradigm will elevate the usefulness of these model systems. The concept was investigated using extracts from Dioclea reflexa (DR) hook which belongs to the leguminous family. There are certain class of compounds in Dioclea reflexa (DR) that have clinical usefulness in both temperate and tropical regions, however the identity of the bioactive compounds responsible for inducing cell death continue to be a major challenge.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Elvis K. Tiburu, Richard Asiamah, Bernard O. Asimeng, Samuel Kojo Kwofie, Emmanuel Nyankson and William N. Gblerkpor",authors:[{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. Asimeng"},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu"}]},{id:"74225",title:"Advanced Biosensing towards Real-Time Imaging of Protein Secretion from Single Cells",slug:"advanced-biosensing-towards-real-time-imaging-of-protein-secretion-from-single-cells",totalDownloads:445,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"Protein secretion of cells plays a vital role in intercellular communication. The abnormality and dysfunction of cellular protein secretion are associated with various physiological disorders, such as malignant proliferation of cells, aberrant immune function, and bone marrow failure. The heterogeneity of protein secretion exists not only between varying populations of cells, but also in the same phenotype of cells. Therefore, characterization of protein secretion from single cell contributes not only to the understanding of intercellular communication in immune effector, carcinogenesis and metastasis, but also to the development and improvement of diagnosis and therapy of relative diseases. In spite of abundant highly sensitive methods that have been developed for the detection of secreted proteins, majority of them fall short in providing sufficient spatial and temporal resolution for comprehensive profiling of protein secretion from single cells. The real-time imaging techniques allow rapid acquisition and manipulation of analyte information on a 2D plane, providing high spatiotemporal resolution. Here, we summarize recent advances in real-time imaging of secretory proteins from single cell, including label-free and labelling techniques, shedding light on the development of simple yet powerful methodology for real-time imaging of single-cell protein secretion.",book:{id:"9883",slug:"biosensors-current-and-novel-strategies-for-biosensing",title:"Biosensors",fullTitle:"Biosensors - Current and Novel Strategies for Biosensing"},signatures:"Lang Zhou, Pengyu Chen and Aleksandr Simonian",authors:[{id:"324950",title:"Prof.",name:"Alex",middleName:null,surname:"Simonian",slug:"alex-simonian",fullName:"Alex Simonian"},{id:"324951",title:"Dr.",name:"Lang",middleName:null,surname:"Zhou",slug:"lang-zhou",fullName:"Lang Zhou"},{id:"324981",title:"Prof.",name:"Pengyu",middleName:null,surname:"Chen",slug:"pengyu-chen",fullName:"Pengyu Chen"}]}],onlineFirstChaptersFilter:{topicId:"689",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"24",type:"subseries",title:"Computer Vision",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. 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He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},subseries:[{id:"22",title:"Applied Intelligence",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",annualVolume:11418,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne University",institutionURL:null,country:{name:"France"}}},{id:"109268",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Ataby",fullName:"Ali Al-Ataby",profilePictureURL:"https://mts.intechopen.com/storage/users/109268/images/7410_n.jpg",institutionString:null,institution:{name:"University of Liverpool",institutionURL:null,country:{name:"United Kingdom"}}},{id:"3807",title:"Dr.",name:"Carmelo",middleName:"Jose Albanez",surname:"Bastos-Filho",fullName:"Carmelo Bastos-Filho",profilePictureURL:"https://mts.intechopen.com/storage/users/3807/images/624_n.jpg",institutionString:null,institution:{name:"Universidade de Pernambuco",institutionURL:null,country:{name:"Brazil"}}},{id:"38850",title:"Dr.",name:"Efren",middleName:null,surname:"Gorrostieta Hurtado",fullName:"Efren Gorrostieta Hurtado",profilePictureURL:"https://mts.intechopen.com/storage/users/38850/images/system/38850.jpg",institutionString:null,institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},{id:"239041",title:"Prof.",name:"Yang",middleName:null,surname:"Yi",fullName:"Yang Yi",profilePictureURL:"https://mts.intechopen.com/storage/users/239041/images/system/239041.jpeg",institutionString:"Virginia Tech",institution:{name:"Virginia Tech",institutionURL:null,country:{name:"United States of America"}}}]},{id:"23",title:"Computational Neuroscience",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",annualVolume:11419,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"24",title:"Computer Vision",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",annualVolume:11420,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. R.",surname:"Neves",fullName:"Antonio Neves",profilePictureURL:"https://mts.intechopen.com/storage/users/1177/images/system/1177.jpg",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"220565",title:"Dr.",name:"Jucheng",middleName:null,surname:"Yang",fullName:"Jucheng Yang",profilePictureURL:"https://mts.intechopen.com/storage/users/220565/images/5988_n.jpg",institutionString:null,institution:{name:"Tianjin University of Technology",institutionURL:null,country:{name:"China"}}},{id:"29299",title:"Prof.",name:"Serestina",middleName:null,surname:"Viriri",fullName:"Serestina Viriri",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOalQAG/Profile_Picture_1620817405517",institutionString:null,institution:{name:"University of KwaZulu-Natal",institutionURL:null,country:{name:"South Africa"}}},{id:"315933",title:"Dr.",name:"Yalın",middleName:null,surname:"Baştanlar",fullName:"Yalın Baştanlar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002qpr7hQAA/Profile_Picture_1621430127547",institutionString:null,institution:{name:"Izmir Institute of Technology",institutionURL:null,country:{name:"Turkey"}}}]},{id:"25",title:"Evolutionary Computation",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",annualVolume:11421,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer",middleName:"P.",surname:"Dadios",fullName:"Elmer Dadios",profilePictureURL:"https://mts.intechopen.com/storage/users/111683/images/system/111683.jpg",institutionString:"De La Salle University",institution:{name:"De La Salle University",institutionURL:null,country:{name:"Philippines"}}},{id:"106873",title:"Prof.",name:"Hongwei",middleName:null,surname:"Ge",fullName:"Hongwei Ge",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Dalian University of Technology",institutionURL:null,country:{name:"China"}}},{id:"171056",title:"Dr.",name:"Sotirios",middleName:null,surname:"Goudos",fullName:"Sotirios Goudos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9IuQAK/Profile_Picture_1622623673666",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"15895",title:"Assistant Prof.",name:"Takashi",middleName:null,surname:"Kuremoto",fullName:"Takashi Kuremoto",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLrqQAG/Profile_Picture_1625656196038",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}},{id:"125844",title:"Prof.",name:"Wellington",middleName:"Pinheiro Dos",surname:"Santos",fullName:"Wellington Santos",profilePictureURL:"https://mts.intechopen.com/storage/users/125844/images/4878_n.jpg",institutionString:null,institution:{name:"Federal University of Pernambuco",institutionURL:null,country:{name:"Brazil"}}}]},{id:"26",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",annualVolume:11422,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:null,institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}},{id:"16614",title:"Prof.",name:"Juan Ignacio",middleName:null,surname:"Guerrero Alonso",fullName:"Juan Ignacio Guerrero Alonso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6HB8QAM/Profile_Picture_1627901127555",institutionString:null,institution:{name:"University of Seville",institutionURL:null,country:{name:"Spain"}}},{id:"3095",title:"Prof.",name:"Kenji",middleName:null,surname:"Suzuki",fullName:"Kenji Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/3095/images/1592_n.jpg",institutionString:null,institution:{name:"University of Chicago",institutionURL:null,country:{name:"United States of America"}}},{id:"214067",title:"Dr.",name:"W. 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The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",annualVolume:11423,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"275140",title:"Dr.",name:"Dinh Hoa",middleName:null,surname:"Nguyen",fullName:"Dinh Hoa Nguyen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRbnKQAS/Profile_Picture_1622204093453",institutionString:null,institution:{name:"Kyushu University",institutionURL:null,country:{name:"Japan"}}},{id:"20259",title:"Dr.",name:"Hongbin",middleName:null,surname:"Ma",fullName:"Hongbin Ma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhDJQA0/Profile_Picture_2022-05-02T08:25:21.jpg",institutionString:null,institution:{name:"Beijing Institute of Technology",institutionURL:null,country:{name:"China"}}},{id:"28640",title:"Prof.",name:"Yasushi",middleName:null,surname:"Kambayashi",fullName:"Yasushi Kambayashi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOQxQAO/Profile_Picture_1625660525470",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"onlineFirst.detail",path:"/online-first/81773",hash:"",query:{},params:{id:"81773"},fullPath:"/online-first/81773",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()