Summary of the data set described by Malas et al. [19].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7927",leadTitle:null,fullTitle:"Selected Topics in Child and Adolescent Mental Health",title:"Selected Topics in Child and Adolescent Mental Health",subtitle:null,reviewType:"peer-reviewed",abstract:"This book addresses a variety of critical themes that relate to child and adolescent mental health and working memory. It focuses on various theoretical perspectives as well as highlighting implications for practice. The topics contemplated include social media and mental health, parent-child interaction therapy (PCIT), the role of e-learning in mental health, perinatal depression and working memory, language, and reading and behaviour. In focusing on mental ill-health, this book addresses a global concern. The causes of poor mental health are complex and multi-faceted. In acknowledging this complexity, it must be recognized that there is no single ‘magic bullet’ that will solve the problem. A multidisciplinary approach is therefore required for approaching the issues, including a variety of interventions. 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He also holds a national training role with a large multi-academy trust. Samuel\\'s research outputs are linked with the Centre for LGBTQ+ Inclusion in Education and the Carnegie Centre of Excellence for Mental Health in Schools at Leeds Beckett University. His research explores the experiences of teachers who identify as Lesbian, Gay, Bisexual and Transgender, with specific emphasis on the impact of sexual orientation on teacher identity and mental health. 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Dr. Muzio graduated in Medicine and Surgery with honors, in 1997, at the Second University of Naples and then undertook postgraduate studies in in Child Neuropsychiatry, magna cum laude, gaining her doctorate in 2002. Currently, she is chief of the multidisciplinary team for the early diagnosis of neuropsychiatric disorders within the first 1000 days of life, Asl Na 3 Sud, Torre del Greco, Naples, Italy. Dr. Muzio acts as an editorial board member for several medical journals. 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At the same time, social media use can be beneficial and have positive effects. This chapter outlines the detrimental and positive effects of social media use for young people. Schools play a critical role in educating young people about how to use social media safely and responsibly. However, schools cannot address all the issues and parents, social media and advertising companies also have a responsibility to protect children and young people from harm. 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We will describe and provide details about PCIT, which is based on both attachment and social learning models, and incorporates an innovative approach to treatment in which therapists coach caregivers “live” via a wireless headset while each caregiver interacts with their child. In addition, we will review research that has examined PCIT with a variety of diverse populations (e.g., children with developmental delay, physical abuse histories, anxiety and depression, and children from underrepresented racial and ethnic minority families), settings (e.g., clinic, home, school) and formats (e.g., individual, group, intensive). Finally, we will present a case study of PCIT with a child younger than 2 years to demonstrate the effectiveness of PCIT and highlight some common challenges and pitfalls that clinicians may face in clinical practice.",signatures:"Perrine Heymann, Brynna H. Heflin and Daniel M. 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Foraging mode has been shown to be a persuasive evolutionary force molding the diet, ecology, behavior, anatomy, biomechanics, life history, and physiology of skinks and lizards.
\r\n\r\n\tThis volume will review the state of our knowledge on the effects of foraging mode on these and other organismal systems to show how skinks and lizards have evolved with foraging mode over a wide taxonomic survey of skink and lizard groups. This review will reveal the continuous nature of foraging strategies in skinks and lizards (especially skinks and lizards living in tropical regions), providing the general reader with an up-to-date review of the field, and will equip researchers with new insights and future directions for the sit-and-wait vs. wide foraging paradigm.
\r\n\r\n\tThis volume will serve as a reference book for Ph.D. students, herpetologists, evolutionary biologists, animal behaviorists, and conservational ecologists.
\r\n\t
One of the major issues of the 21st century, without any doubt, is the viral respiratory disease discovered at the end of 2019, the COVID-19. Using next-generation sequencing, the pathogen related to COVID-19 was described as a novel coronavirus, which is related to the SARS-coronavirus described in 2003, mainly in Asia, from the molecular and phylogenetic aspects [1].
A severe respiratory disease was reported in Wuhan, Hubei province, China. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan [2].
The first case reported in the medical literature was that of a 41-year-old man who was hospitalized in the Central Hospital of Wuhan. The patient was admitted to the hospital reporting an extensive set of symptoms since one week before his admission on December 26, 2019, which included dry cough without sputum, fever, weakness, chest tightness, and widespread pain. Normal signs were observed at physical examination on abdominal, cardiovascular, and neurological features.
Among the biomarkers analyzed, one of the most important findings was the raised C-reactive protein (CRP) level of 41.4 mg/L (standard at 0–6 mg/L) whose circulating concentrations rise in response to inflammation. Followed by the higher CRP, the biochemistry cardiac panel also showed raised myocardial infarction markers, such as lactic dehydrogenase (LDH), aspartate aminotransferase (AST), and creatine kinase (CK). Taken together, these biomarkers strongly indicated a severe acute inflammatory phase with the ongoing cardiac effect to be controlled. Mild lymphopenia with less than 9 × 10e5 cells per mL with normal platelet counts completes the first patient’s overview [2].
Pulmonary function and lung aspects were investigated in this patient in order to do the etiological diagnosis. Hypoxemia was observed according to oxygen levels of 67 mm Hg. Lungs’ aspect was set by chest radiographs on day 1 of hospital admission, which was the 6th day of disease progression. The images showed abnormal features with focal and patchy consolidation in both lungs, beyond air-space shadowing such as ground-glass like opacities [2].
Image examination of the chest shows a consolidation pattern at computed-tomography (CT) scans: bilateral focal consolidation, lobar consolidation, and patchy consolidation, especially in the lower lung. Five days after admission, at the 11th day of disease progression, a chest radiograph revealed a bilateral diffuse patchy and fuzzy shadow [2].
With the advancement of the pandemic, what was seen as a respiratory disease became a more complex disease and new studies were set up to list other complications and associated risk factors.
Many factors can contribute to increasing the risk for severe COVID-19, in some cases followed to death. The main comorbidities described are high age, obesity, diabetes, and hypertension. Beyond the inflammation and impaired coagulation, focal damage in some tissues/organs is also related to the COVID-19 spectrum, such as liver, kidney, and heart [3].
Thrombotic complications seem to emerge as an important issue in patients infected with COVID-19. Preliminary reports on COVID-19 patients’ clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation.
In the course of the COVID-19 studies, a clear association with coagulation dysfunction was pointed in many cases. Intra-alveolar clots were prominent findings in COVID-19 patients who developed severe respiratory disease. The same findings have been described in both clinical and animal model studies. Apparently, an impaired response in the prothrombotic pathway is in charge of diffuse alveolar hemorrhage since it is related to overt clot formation [4].
In the recent publication “Should COVID-19 be branded to Viral Thrombotic Fever?,” the authors intended to frame COVID-19 in more clinical terminology, making an analogy to Viral Hemorrhagic Fever (VHF). In this article, the authors reported: “We found irrefutable evidence in the current literature that COVID-19 is the first viral disease that can be marketed as a viral thrombotic fever” [5]. Although this is a very categorical statement, considering the small number of studies exclusively dedicated to the characterization of COVID-19 as a thrombotic fever, it is very important to consider this designation. Categorizing COVID-19 as a febrile variant of thromboembolism adds a series of procedures to be adopted in patients’ care. This approach can advance the treatment adequacy by many steps, making it as more personalized as possible.
The risk of thromboembolism in COVID-19 is documented in an article published in The Lancet [6]. This finding brings up an important issue to be screened on COVID-19 patients: the impact of inherited predisposition to thrombotic events in patients affected by COVID-19.
Given this, thrombophilic genetic abnormalities in variants were widely reported in the medical sciences such as Factor V Leiden (F5), Prothrombin (F2), and the polymorphism in methylenetetrahydrofolate reductase (MTHFR), among others [7]. These polymorphisms could put a patient’s carriers of mutant alleles in the Risk Group, beyond the well-known factors, such as elderly patients, hypertension, cardiac and respiratory diseases, cancer, and diabetes [8].
In this chapter, we present a brief review of the three main DNA polymorphisms associated with thrombophilic events and suggest the inclusion of these, as well as the coagulation profiles of their carriers, as aggravating comorbidities of COVID-19.
Firstly, a brief review of the main molecular characteristics of these polymorphisms is as follows:
It represents one of the main causes of resistance to protein C, as mutation increases the risk of thrombotic disease three to ten times for heterozygous carriers and eighty times for homozygous carriers [4, 9]. About 90% of cases of protein C resistance result from point mutation in the coagulation factor V gene. This mutation occurs in exon 10 of the factor V gene, causing a substitution of the G/A base (Guanine/Adenine) in nucleotide 1691, resulting in the exchange of Arg (Arginine) by Gln (Glutamine) at position 506 of the protein, one of the main cleavage sites for protein C activation [10]. FVL is the most common inherited cause of venous thrombosis.
In patients with increased protein C resistance, venous thrombosis without known etiology and familiar history of unexplained thrombosis, the FVL mutations’ screening should be considered beyond a strong clinical investigation. The diagnosis for FVL mutations is based on well-known molecular biology approaches. The clotting time-based functional assays and genetic biomarkers’ screening become together the basis for clinical decisions. It is a very important step to guide the clinical approach, balancing the long-term anticoagulation with its side effects and benefits [11].
Briefly, the mechanism of action of factor V could be described as follows. Factor V is cleaved by thrombin on its B domain at cleavage sites R709, R1018, and R1545, producing an amino-terminal heavy chain and a carboxy-terminal light chain, which binding themselves create a dimer called Factor Va (FVa). In turn, FVa binds with Factor Xa creating a prothrombinase complex which on the platelet surface converts prothrombin (II) to thrombin (IIa). FV can also be split by the action of activated protein C (APC) at the cleavage site R506 before it is cleaved by thrombin. It results in the inactivation of factor V to factor Vi and the generation of an imperfect peptide, the Factor Vac, which apparently has anticoagulant characteristics by stimulating APC- and protein S-mediated inactivation of factor VIIIa. A second mechanism of thrombosis observed with FVL is its diminished cofactor activity with APC and phospholipid in the inactivation of factor VIIIa to factor VIIIi. Taken together, FVL is a prothrombotic mutation due to a combination of a gain of function, with higher prothrombin activation, and loss of function due to low cofactor activity with APC in the inactivation of factor VIIIa. Normally, patients with defective FVL have a variable thrombophilia phenotype, have increased thrombin generation, have a longer factor Va half-life in plasma, and are resistant to factor Va inactivation [11]. A larger C-terminal peptide results if factor V is cleaved by APC before it is cleaved by thrombin [12].
The G20210A mutation of prothrombin causes a G to A transition at the nucleotide position 20,210. This mutation increases circulating prothrombin activity and levels [13]. PTB is a vitamin K-dependent coagulation factor, which in its active form is cleaved, forming in this way the thrombin. The thrombin catalyzes many other coagulation-related reactions and acts as a serine protease that converts fibrinogen to fibrin. PTB mutations are the second-most common inherited thrombophilia. In the United States, the heterozygous carrier frequency is about 1–2%, accounting for approximately 6–18% of VTE cases. Hyperthrombinemia has been associated with a mutation in the 3′ termination of the PTB gene, called c.∗97G > A, which results in increased production, due to the increased PTB mRNA expression and stabilization. An increased amount of circling prothrombin can lead to higher thrombin generation in the plasma, followed by coagulation activation and thrombosis. This mutation is also more common in the Caucasian population and is rare in other ethnic groups. Homozygosity, for this mutation, is found in about 1 in 10,000 individuals. Transheterozygosity for FVL and prothrombin c.∗97G > A affects about 1 in 1000 individuals. Additional variations identified in the 3′-untranslated region of the prothrombin gene include changes at positions 20,207, 20,209, 20,218, and 20,221. High PTB levels also inhibit APC-mediated inactivation of activated FV and factor VIII. The prevalence of prothrombin G20210A mutation varies in different countries and ethnic groups, being highest in Caucasians, especially those in Southern Europe, and in the Mediterranean region [14].
Hotoleanu, in his article Genetic Risk Factors in Venous Thromboembolism, described that MTHFR acts on homocysteine metabolism, reducing 5.10-Methylenetetrahydrofolate to 5-methylenetetrahydrofolate. The enzyme polymorphisms generally occur at two sites, at position C677T, which characterizes the substitution of alanine for valine at codon 222, and at position A1298C, which occurs due to the substitution of glutamine for alanine at codon 429, the second mutation being less aggressive than C677T, which is homozygous and in the presence of low levels of folate decreases enzyme activity leading to hyperhomocysteinemia, a risk factor for thrombophilia [15].
Simoni et al. corroborate this theory, when they describe that mutations in the MTHFR enzyme reduce its activity leading to hyperhomocysteinemia. Increase in homocysteine levels is a risk factor for thromboembolism [16].
Considering patients with COVID-19, especially those seriously ill, there are several potential risk factors for venous thromboembolism, including infection, immobilization, respiratory failure, mechanical ventilation, and use of a central venous catheter [17, 18]. Wang et al. reported in their Lancet article that patients at a high risk for venous thromboembolism had worse results with COVID-19 than patients at a low risk for venous thromboembolism, suggesting that these patients may require more attention in the event of rapid deterioration [6].
A systematic review and meta-analysis done to analyze the thromboembolism risk on COVID-19 patients showed that its occurrence is high and associated with the worst clinical development. A total of 8271 patients from 425 eligible studies were included in the meta-analysis. In summary, the data set showed that COVID-19 patients had a higher risk of mortality, as described in Table 1 [19].
Overall venous thromboembolism (TE): 21% (95% CI: 17–26%) ICU: 31% (95% CI: 23–39%) |
Overall deep vein thrombosis rate: 20% (95% CI: 13–28%) ICU: 28% (95% CI: 16–41%) Postmortem: 35% (95% CI: 15–57%) |
Overall pulmonary embolism rate: 13% (95% CI: 11–16%) ICU: 19% (95% CI: 14–25%) Postmortem: 22% (95% CI: 16–28%) |
Overall arterial TE rate: 2% (95% CI: 1–4%) ICU: 5% (95% CI: 3–7%) |
Pooled mortality rate among patients with TE: 23% (95% CI: 14–32%) and Pooled mortality rate among patients without TE: 13% (95% CI: 6–22%) |
The pooled odds of mortality among patients who developed TE was 4% higher compared to those who did not (OR: 1.74; 95% CI: 1.01–2.98; |
Summary of the data set described by Malas et al. [19].
Our suggestion of early detection and greater attention in COVID-19 patients with aggravating factors of thromboembolism may be addressed to the data found by Wang and colleagues [6]. Considering the correct prophylaxis, the majority of the venous thromboembolism occurrences could be prevented, mainly on patients with a higher risk for it. In spite of that, from the 140 patients investigated in the cohort, only 7% (10 patients) were maintained under anticoagulant therapy during their hospitalization. Among them, one received rivaroxaban and nine received heparin. It is a low proportion compared to the total number of patients with high risk to develop venous thromboembolism in their cohort. This finding possibly indicates that the prophylactic approach applied in the patients with COVID-19 was not adequate.
Other coagulation disorders observed in patients with COVID-19 also support the idea that a preliminary analysis of the genetic factors involved may better guide the therapeutic approach to be adopted. COVID-19-associated coagulopathy and disseminated intravascular coagulation (DIC) are being described as common findings in these patients. It is known that the pathophysiology of DIC associated with COVID-19 differs from that of septic DIC, and in this context both thrombotic and hemorrhagic pathologies must be observed. Thrombosis events in COVID-19 include macrothrombosis (MAT) and microthrombosis (MIT), and it is important to note that the diagnosis of MIT depends on coagulation and fibrinolysis markers. Consequently, molecular nuances can have a major impact on the worsening of the thrombohemorrhagic condition in different individuals [20, 21].
Screening and inclusion of COVID-19 patients with genetic abnormalities in thrombophilic conditions could guide the medical team to identify possible aggravating complication factors even if their patients are not in the group pre-determined risk, described by the World Health Organization (WHO) [8].
The treatment of COVID-19 is based on antiviral therapy, treatment to contain the cytokine storm, and treatment of thrombosis. Rather than providing uniform treatment, a method best suited for severity and stage should be selected. Considering the molecular profile of each individual can be an important tool in this race against time that characterizes care for patients with COVID-19. In this scenario, COVID-19 could be another exponent for a pharmacogenomics approach to the treatment of human diseases and it proved to be a challenge for humanity in the 21st century. The complications, sequels, and deaths took on catastrophic proportions. Despite the speed with which a significant range of vaccines were presented, comprehensive coverage worldwide is likely to face dares.
In the mind of most people, drinking coffee is just to increase the body\'s resistance to sleepiness. In fact, coffee can provide so many benefits for human life. Ibn Sina (1000 AD) has investigated the chemistry of coffee. His document is the first known document dissecting coffee from medical and health sciences. The results of subsequent studies found that drinking coffee can prevent uterine cancer, and can improve memory and concentration for workers. Drinking coffee for children once a week is believed to strengthen the heart. Meanwhile, for women, drinking coffee can be used as an alternative choice in dieting, because the efficacy of coffee can delay hunger.
In Makassar city, before 2000, the existing coffee shops were only used to satisfy the desire for coffee. In the next decade, the function of the coffee shop became more diverse. Starting from a place to discuss daily social problems, a place for socialization for the rulers and politicians, a means of business meetings, to a means of self-expression.
The coffee shop has developed into a medium for expressing lifestyle and class identity. Visiting coffee shops has turned into a symbolic code for certain circles to actualize their existence in social groups. This can be seen from the shop\'s visitors, who are now not only men but also women.
Changes in coffee drinking patterns and behavior are increasingly developing along with globalization, which is emphasized by media imperialism. For Klapper, the mass media is able to manipulate consciousness. By Merton, the media can smooth out coercion so that it looks like persuasion [1]. The globalization of the media has played a role in the spread of the culture of enjoying coffee in coffee shops. Contemporary culture is related to people\'s tastes. According to Bourdiau, the taste is an opportunity both to experience and to assert one\'s position in the environment [2].
Visiting a coffee shop is not just enjoying a delicious cup of coffee. Now the attention is no longer on what is drunk in coffee shops, but more than that, namely how coffee is processed, served, and drunk. Changes in people\'s patterns and behavior in enjoying coffee cannot be separated from the influence of the globalization of the coffee shop business which has increased in recent years. The coffee shop business in the era of globalization does not only work on coffee products, it is further than that, namely consumers by formulating contemporary business jargon which is full of symbolism. Enjoying a cup of coffee in a modern coffee shop for some people has become a symbol of luxury, exclusivity, and prestige, as well as a marker or identity of social class. The change in the meaning of the coffee shop is also inseparable from the social interaction of the community.
In Blumer\'s perspective of symbolic interaction, the change in meaning can be seen from three premises, first, humans act towards something based on the meaning that something has for them; second, the meaning comes from one\'s social interactions with other people; and third, the meaning is perfected when the process of social interaction takes place [3].
As a result, it also has an impact on changes in society. Consumerism began to take root in urban society. Consumptive-ism in this case is defined as the use or consumption of goods that are pure because of the demands of social prestige and not out of necessity. This fact shows that cultural space is not only created by the community itself, but it is also a part of the expansion of global culture which intentionally or not has expanded to coffee shop spaces. Cultural globalization is a form of transnational expansion towards cultural grafting (heterogeneity). This process towards homogeneity is often associated with cultural imperialism which is characterized by increasing international influence on certain cultures. So, do not be surprised if coffee shops will one day replace social spaces that have been established before. The coffee shop has become a part that not only has become a consumptive medium for certain classes but has shown the socio-cultural characteristics of the community.
The proliferation of coffee shops in Makassar city has encouraged the growth of public spaces. Coffee shops are no longer just a means of meeting the need for coffee but have changed their shape and face as a social and cultural space, capable of becoming cultural glue. This is possible because coffee shops are able to reduce the barriers to differences in the social, economic, and cultural backgrounds of visitors, by designing an atmosphere and communication that is as loose and fluid as possible. So, that every citizen, from various social classes, can fuse together in a social space full of dynamics. Coffee shops can also trigger the creation of openness and exchange of information because the social space provided by coffee shops is so free and open. Coffee shop visitors are free to talk about problems in social and cultural life without intervention and intimidation from other groups or by the authorities and bureaucracy.
The phenomenon of the rapid development of coffee shops in Makassar city today, not only reinforces existing social changes but also serves as a buffer for socio-economic strength because coffee shops are able to accommodate the diversity of community members. In addition, coffee shops are not only able to increase the economic level of middle and upper-class coffee shop entrepreneurs, but also provide income for informal sector entrepreneurs who are generally lower-class people.
The change in the meaning of coffee shops in Makassar city from traditional coffee shops that focus only on coffee consumption as mere physical fulfillment, to modern coffee shops equipped with various facilities that allow coffee shops to play a role as a means of business, information, socialization, and imaging. These coffee shops with modern management are now more existent in Makassar city, while traditional coffee shops seem to be running in place and some of them have even gone out of business.
The habit of drinking coffee in the urban community of Makassar city is more dynamic with very loose communication patterns. The author\'s initial observations about the characteristics of coffee shop visitors in Makassar city, that there are several characteristics of coffee shop visitors. The first, are those who are classified as coffee connoisseurs to satisfy their physical needs. Second, are those who visit coffee shops because they enjoy socializing and building relationships. For people like this, with expenses that are not so big, they can hang out as much as they want in the coffee shop while enjoying the atmosphere provided at the coffee shop, including the sensation of serving, good-looking waiters, and free internet facilities. Third, are those who are classified as business people. They use the shop as a space for business transactions or use the coffee shop\'s social space to build networks and business relationships. Fourth, are those who use coffee shops as a means of obtaining information. Included in this group are students and journalists. Fifth, are political actors who make coffee shops a place to disseminate ideas and political imagery.
The history of coffee has been recorded since the ninth century. Coffee is a plant native to Ethiopia which was originally only grown in highland areas. When the Arabs began to expand their trade, coffee beans have also expanded to North Africa. It was from North Africa that coffee beans began to spread from Asia to the European market.
Since the beginning, the coffee plant was not as popular as it is today. Coffee is just an ordinary plant with no known benefits. The beginning of knowing the benefits of coffee for humans is illustrated in the story of a goat herder in Ethiopia. The benefits of coffee were first discovered by Kaldi, a goat herder in Ethiopia. Kaldi found his goats behaving strangely after eating coffee plants. The goats were jumping around like they were drunk.
Kaldi was surprised and found out what was causing the goats to dance. Kaldi then saw a bunch of shiny red seeds in the bushes. The grain—later known as coffee—was being eaten by the goats. With curiosity, finally felt the difference after trying to eat the seeds.
Meanwhile in Indonesia, coffee was brought to Indonesia by a Dutchman named Zwaardecroon, who brought some seeds of the Arabica Mocca coffee plant from Mecca to Bogor in the seventeenth century. Arabica coffee was first grown in a place east of Jatinegara. The place is now known as Pondok Kopi. Arabica coffee then spread to various areas in West Java, such as Bogor, Sukabumi, Banten, and Priangan. From the island of Java, enter other areas such as the islands of Sumatra, Sulawesi, Bali, and Timor [4].
Bourdieu formulated the concept of habitus as a sociological and philosophical analysis of human behavior. Habitus are values that are lived by humans and are created through a process of values that lasts a long time so that they settle into ways of thinking and patterns of behavior that persist in humans.
Dialectically, habitus is a product of the internalization of the structure of the social world [5]. Habitus is a subjective structure that is formed from the experience of individuals relating to other individuals in a network of objective structures that are in social space. Habitus can be said to be a cultural unconscious, namely history that is unconsciously considered natural, which is formed from the results of learning through parenting, playing activities, and also community education in a broad sense.
Bourdieu argues that the way actors feel is based on their position in the social space and constructs social life as a sociological study. However, perceptions and constructions that occur in social life are driven and controlled by structures. Bourdieu\'s thinking is reflected in his own definition of his theoretical perspective:
In the view of Bourdieu [5] habitus are:
So, the habitus will be different, depending on the form of a person\'s position in social life. Not everyone has the same habits, people who occupy the same position in social life tend to have the same habits. In this sense, habitus can also be a collective phenomenon.
Habitus allows people to understand the social world, but having multiple habitus means that social life and its structure cannot be imposed uniformly on all actors. Actions mediate habitus and social life. On the one hand, habitus is created through practice (action); on the other hand, habitus is an action created by social life [7].
Habitus merely suggests what people should think and what they should choose to do. According to Bourdieu, habitus functions below the level of consciousness and language, beyond the reach of observation and control by volition [8]. But it manifests itself in our very practical activities such as the way we eat, walk, talk and even blow our noses.
Bourdieu focuses on differences in the "taste" of beauty between various social classes towards various cultural objects that contain the value of beauty. For Bourdieu in Ritzer and Goodman [9]:
In Bourdieu\'s view, "through the application of habitus and taste, people classify objects and at the same time they are in the process of classifying themselves". Bourdieu further explained that:
Bourdieu also connects taste with habitus. Tastes are shaped by long-lasting habitus; not shaped by superficial opinion and rhetoric. Furthermore, Bourdieu explained that the environment and habitus mutually determine each other. This can be seen from his explanation of the two things, namely:
Bourdieu views that the driving force of all human behavior is the pursuit of honor. Bourdieu argues that his main goal is “to exist in a social space, occupy the point where he becomes an individual in a social space, is to become a differentiator in order to become prominent in that space [10] . Bourdieu further argues that the environment offers almost endless opportunities to pursue honor.
According to Kaldun, "humans are basically created as social beings, namely creatures who always need other people to maintain their lives so that their life with society and social organizations is a must" [11]. Because the relationship between one another, both in the form of groups and individuals is a picture of the development of society in realizing its dynamism.
Symbolic interactionism theorist Cooley [12] sees "society is a mental phenomenon, the relationship between people\'s ideas". Meanwhile, Thomas, Henri, Susan, Bridget, added that "society is in my mind like the relationship and mutual influence in certain ideas which are named "I". Bahtiar [12] sees "society and individuals are not two separate realities, but two sides or aspects of one and the same reality. The two are like two sides of a coin that cannot be separated.”
These human characteristics illustrate how meaningful social interaction is in human life. Young and Raymond stated that "social interaction is the key to all social life because, without social interaction, there will be no life together" [13]. Social interactions that take place are basically based on several factors, including imitation, suggestion, identification, and sympathy. These factors can move individually or in combination. For this reason, according to Soekanto [14], "social interaction is impossible if it does not meet two conditions, namely the existence of social contact (social contact) and communication". Meanwhile, Mead [15] is of the view that "only by adjusting to the expectations of others, interaction will be possible".
In sociology, the unit of analysis is a social event called social interaction between two or more people. Social interaction can be classified into various types of social relationships that are fostered by a number of people, actors from one or two groups/organizations. Various social relations between people from one or two groups called inter-group social relations according to their characteristics can be classified into various social processes, there are social processes that bring people closer and there are social processes that distance people.
Social interaction can be classified into several forms of interaction. Gillin and Gillin [16] divide the form of interaction into two parts, namely: (1) associative processes (accommodation, assimilation, and acculturation), and (2) dissociative processes (competition, opposition). Meanwhile, the form of interaction is divided into three parts, namely: (1) opposition (competition and opposition), (2) cooperation that results in accommodation, and (3) differentiation (each individual has the right and obligations on the basis of differences in age, sex, and work. As for Tomatsu Shibutani, distinguishes the form of interaction into (1) accommodation in routine situations, (2) expression of meetings and suggestions, and (3) strategic interaction in conflict; development of mass behavior.
In discussing social interaction for the Bugis-Makassar community, the tradition that should be put forward is tudang sipulung. The term tudang sipulung literally means “sitting together”, which has the meaning and purpose to solve their needs and problems in their lives and daily lives in a democratic manner. A pallontara (“interpreter of Lontara”), Andi Burhanuddin explains in Bugis language that:
The presentation indicates that the Tudang sipulung tradition has been carried out by the Bugis-Makassar community as a common space for deliberation and consensus in order to find solutions to problems faced by the community.
Anwar Ibrahim [17], states that "all problems in people\'s lives can be blamed for being blamed”. The implementation of tudang sipulung can be official or informal. Tudang sipulung, which is informal in nature, is usually carried out in a family environment or between families who discuss family issues such as marriage and proposals. While matters concerning social issues, or important decisions within a village, between villages or kingdoms, are usually carried out officially led by a matoa (who is elder according to custom) as the leader (king) of a village/country (wanua).
This illustrates that the position of tudang sipulung for the Bugis-Makassar community is very important. This can be seen from its goal of being a bridge or mediator for the resolution of various problems, both problems with a small scope, namely family, as well as issues with a wider scope, such as political and state issues. For the people of Makassar city who are more modern, the emergence of coffee shops today is not only a means of satisfying the need for the pleasure of coffee, but more than that, namely as a gathering place while discussing various life problems, both those concerning social, cultural and political issues. So it is not an exaggeration to gather at a coffee shop to be described as a manifestation of the tudang sipulung tradition.
Communication is a means of driving a social process that allows interaction between humans and makes humans as social beings. Humans communicate with symbols. According to Rivers, Jensen and Peterson [18], "humans are creatures who know how to react to their physical environment, but also to the symbols they make themselves”. Meanwhile, Kenneth Boulding compares humans with animals in terms of communication, according to him “animals do not have the notion of consciousness and a symbolic environment (language, art and myth) like humans do; So, humans are unique not only because of their ability to reason but also because of their symbolic world [18].
Humans always communicate with symbols. This is what underlies Rivers et al see humans as creators of symbols. According to him "the world is a pseudo, a network or a series of symbols of his creation". In line with Rivers et al., Epictetus argues that "what strikes humans are not objects, but their own opinions and images about these objects" [18]. In interacting, for Mead, “mind and self are part of human behavior, namely part of their interaction with other people. This interaction allows him to know the world and himself” [19], thus, “thinking can be understood as a result of internalizing the process of interacting with other people”, continued Mead [15].
Meanwhile, another thinker of the flow of symbolic interactionism, namely Blumer emphasized that symbolic interaction includes "interpretation of action". Blumer rests on three premises, namely: "(1) humans act toward things based on the meanings that things have for them, (2) those meanings come from one\'s social interactions with other people, and (3) these meanings are perfected when the process of social interaction takes place” [20].
Symbolic interactionist theorists tend to agree on the importance of causality in social interaction, i.e. focusing on human action and interaction, not isolated mental processes. "The main concern is not how the human mind creates the meaning of symbols, but how they learn it during interactions in general and during the socialization process in particular" [21]. One aspect that is put forward in discussing social interaction is socialization. For symbolic interactionists, “socialization is a dynamic process that enables people to develop the ability to think, to grow humanly [22]. This is what Christopher [23] calls the interaction of this dynamic symbol with a “dance” involving a partner. For Ritzer and Goodman [24] interaction is a process when thinking skills are developed and expressed. All kinds of interactions, not just interactions during socialization, polish our thinking abilities. Beyond that, thinking builds the process of interaction.
The use of symbols allows actors to transcend time, space, and even their own person. Through the use of symbols, actors can imagine what it would be like to live in the past or what it would be like to live in the future. In addition, actors can go beyond themselves symbolically and imagine what the world would be like from someone else\'s point of view. This is the most well-known symbolic interactionist concept, namely taking the role of another [25]. In the process of symbol interaction, it is the person who communicates the meaning symbolically to the other people involved. Others interpret the symbols and direct-action responses based on their interpretation. In other words, in the interaction of symbols, actors are involved in influencing [23]. For symbolic interactionists, actors have at least some autonomy. They are not simply restrained or directed; they are able to make unique and independent choices. In addition, they are able to develop a life that has a unique style (Perinbanayagam, in Ritzer and Goodman, [23]).
Social change according to Gillin and Gillin in Soekanto [26] is "a variation of accepted ways of life, either due to changes in geographical conditions, material culture, population composition, ideology or because of diffusion or new discoveries. in society". In line with this understanding, Koening argues that "social change refers to the modifications that occur in the patterns of human life that occur due to internal and external causes".
Sztompka [27] in his book Sociology of Social Change, details the definition of socio-cultural change as follows:
Social change is a transformation in the organization of society, in the mindset, and in behavior at a certain time.
Social change is a modification or transformation in the organization of society.
Social change refers to the variation of relationships between individuals, groups, organizations, cultures, and societies at a particular time.
Social change is a change in behavior patterns, social relations, institutions, and social structures at a certain time.
Soekanto [28] sees the impact of technological and economic conditions as the cause of social change. This can be seen from his statement that "these conditions are considered the basis of social organization and values are the result of the impact of technological and economic situations". Meanwhile, Astrid sees "change in society in a broad sense defined as change or development in a positive or negative sense. The meaning of social change has two dimensions, namely social change as regression and as progress [29].
The proliferation of coffee shops in big cities in Indonesia cannot be separated from the currents of modernization and globalization of the world. Modernization is characterized by the emergence of new consumption tools, mostly United States innovations that have not only transformed consumption in the United States but are also exported aggressively to most other parts of the world where they have an even greater impact on consumption [30]. Modernization tends to expand its network of reach, especially its space, and this is what is called globalization. For Giddens in Martono, [31] modernity is:
Dynamic urban communities with all forms of busyness really need the means to relax and release fatigue, emotions, and stress in the world of work. This is what Sztompka alluded to in Martono [32] that:
The presence of a coffee shop that provides a relaxed and relaxed atmosphere is an alternative choice for city residents to relax. The development of coffee shops is no longer only caused by the culture of consumerism that develops in modern society but is also caused by a shift in the distribution of social prestige. As stated by Martono [33] that:
The development of coffee shops in Indonesia in the last decade cannot be separated from the influence of the mass media. The increase in number and its even distribution in almost all major cities in Indonesia is one of the justifications that the mass media, especially television, has turned the world into a global village. Instant and worldwide communication give substance to Marshal McLuhan\'s idea which was first expressed in the 1980s that the world will become a global village. So it is only natural that Hanners [34] argues that “Western culture will dominate throughout the world. The whole world will become a copy of the lifestyles, consumption patterns, values and norms and ideas and beliefs of Western society”.
The phenomenon of the rise of coffee shops in various corners of cities in Indonesia (including coffee shops and cafes that provide coffee) both international coffee shops and local coffee shops, can be said to be the influence of opening an international coffee shop franchise with the largest network in the world, Starbucks, around 1998 with 11 branches in major cities in Indonesia. This has had a major impact on the lifestyle of the urban community, especially in terms of enjoying coffee.
The development of coffee shops in Makassar city, both in terms of quantity and quality, has opened up space for the people of Makassar city to socialize. The patterns of interaction and communication created in coffee shops are so relaxed, loose, and fluid, that cultural boundaries seem to be melting. Various forms of negotiation, conflict resolution, business transactions, as well as consolidation, and political imagery can even be completed in the coffee shop space. This phenomenon makes today\'s coffee shops a new asset for the people of Makassar city which deserves appreciation for being able to become a bridge for the development of local wisdom, namely tudang sipulung.
When viewed from its cultural-historical roots, coffee shops are not impossible to appear as a substitute for entertainment, a place to hang out, and a place to share information for the people of Makassar city. Therefore, the cultural process that develops so naturally must be appreciated because it has an important role in the transformation of space which is currently being symptomatic in almost all corners of Makassar city.
The existence of a coffee shop in Makassar city has created a new identity, through the creation of a space where Makassar city residents from various economic, educational, and social status backgrounds meet. Coffee shops are also a means of glue for the cultural diversity of the people of Makassar city. But on the other hand, the creation of community centers of this kind is also part of a process of cultural escalation towards the search for a new identity, especially for the younger generation. Chaney [35] in his book Lifestyle argues that “a lifestyle or ways of behaving that are related to conventional expectations which then form new patterns of choice through ways of taste patterns that shape and support the hierarchy of privileges and status".
The culture of enjoying coffee in coffee shops can be categorized as a popular culture when referring to Agger\'s opinion, according to him, popular culture has a lot to do with everyday problems that can be enjoyed by all people or certain people [36]. Popular culture has more influence on groups of young people and is the center of society\'s ideology and culture, even though popular culture continues to be a contradiction and debate [36]. Popular culture also becomes part of elite culture in certain societies and shows more of the entertainment side, which then seems more consumptive. This is what underlies Dyer by arguing that "entertainment is a personal need of the society that has been influenced by the capitalist structure" [37].
Popular culture can be grouped into several streams, namely: (a) culture is built based on fun but not substantial, and relieves people from the boredom of working all day long, (b) popular culture destroys traditional cultural values, (c) culture becomes a big problem in the view of Marx\'s capitalist economy, and (d) popular culture is a culture that drips from above [38]. The culture of drinking coffee for urban people with modern characteristics is closely related to the view of time. Sztompka [39] sees “modern consumer society is marked by shopping and holiday seasons. As a result, the date, apart from having a calendar meaning, is also culturally meaningful for certain people.”
Sztompka [40] describes the characteristics of modernity in everyday life which can be seen in the following phenomena:
The culture of consumerism in modern society can be seen from several aspects. Consumerism is a form of expansion of capitalist commodity production which has led to an increase in the widespread accumulation of material culture in the form of consumer goods and places of purchase and consumption. This has led to the growth of consumption activities and the prominence of the use of leisure time in contemporary western society.
Meanwhile, the sociological perspective sees that a person\'s satisfaction obtained from consumed goods is related to his socially structured access. The focus of this perspective lies in the various ways people use goods, in order to create social bonds or social differences. Another perspective is the emotional enjoyment of consumption activities and especially the places of consumption activities that cause arousal and aesthetic pleasure directly to the body. What unites a number of writers are the attention to consumption as a communicative activity rather than an instrumental activity. The focus of attention on images, signs, and symbols of consumption also causes renewed interest in personal identity rather than collective practice [41].
On the other hand, Bourdieu in Scott [41], sees consumption as motivated by the need for social groups to achieve status through differences that strengthen the class position. For Bourdieu, “a sense of judgment is rooted in habitus, is a marker of social class and is closely linked to the hierarchy of access to economic capital, cultural capital and social capital”. This is what underlies Scott\'s statement that consumerism emphasizes consumer culture and personal identity.
Discussions and debates in public life show that democracy needs space to share experiences and correct its implementation in state life. This is what Jurgen Habermas calls the public sphere. The public sphere for Kellner is a place for information, discussion, contestation, political struggle, and organization, which includes broadcast media and new cyberspace, as well as face-to-face interactions in everyday life. What is meant by public space here is all organs of information and political debate, such as newspapers and journals, as well as political discussion institutions, such as parliaments, political clubs, salons and public assemblies, drinking places and coffee shops, meeting halls, and public spaces. Another public space, where discussions on social, political issues can take place.
Habermas identifies the public sphere as an area of social life that ensures access for all citizens to interact, conduct free rational discussions, identify common problems and, through these discussions, influence political action. In Habermas\' view, the public sphere is:
Habermas explained that the "public sphere refers to the functions of criticism and control of state authorities which are carried out by the public informally, as well as formally during periodic elections" (Imron Rosidin).
Habermas argues that in seventeenth and eighteenth century Europe (and, in particular, in England), the gradual spread of capitalism made possible the emergence of a different kind of public sphere: the “bourgeois public sphere”. The bourgeois public sphere is increasingly becoming a significant part of social life, made up of private individuals gathered together in public places (such as the coffee shops of the seventeenth century in London, the salons of France, and the table societies of Germany. in the eighteenth century) to elaborate on the key issues of the time (particularly political affairs) and exchange views and opinions on matters important to the common good.
The position of public space for urban communities is very important, considering its function in providing space for people to interact and socialize with social and cultural issues freely without pressure. The development of coffee shops in Makassar city cannot be separated from the influence of modernization and globalization which is strengthened by the mass media. The coffee shop that is becoming a trend in the United States has exported its image to Indonesia. Modern coffee shops that have sprung up and dominate the current coffee shop business in Makassar city are stalls managed by owners of large capital. With adequate capital, good management, such coffee shops are able to exist in the midst of coffee shop business competition because they are able to capture market tastes. Meanwhile, the coffee shops that existed earlier, but were not accompanied by adequate capital, management, and management that followed the tastes of the market, then such coffee shops will run in place or even go out of business.
In Makassar city, Warkop Phoenam (“
From the perspective of a global cultural approach, we see that globalization is driven by cultural uniformity based on the mass media so that it threatens culture and national identity. This is what underlies McLuhan\'s term global village with the basic idea being that "the spread of mass media, especially television and now the internet, aims that everyone in the world can be exposed, almost instantly, to the same image.
Horton and Hunt [42] see it from the point of view of "whether an action is important or not important".
Values are collective (together) ideas about what is considered good, important, desirable, and considered worthy, as well as about what is considered not good, unimportant, unwanted, and inappropriate in a culture. Values refer to things that are important in human life, both as individuals and as members of society. There are three classifications of social values: (1) material value, namely, everything that is useful for the body or tangible objects that can be used as human physical needs, (2) vital value, is everything that is useful for humans so that they can carry out activities or activities in his life, (3) spiritual values, (spiritual) humans that are universal.
The coffee shop that exists in Makassar city today is a coffee shop that has experienced a shift in meaning from a traditional coffee shop that only offers coffee as a means of mere physical need to a modern coffee shop that offers sensation and atmosphere (relaxed atmosphere, sexy waiters, internet facilities). Free and various other supporting facilities). So that visitors are happy to spend their time at the coffee shop. In modern coffee shops, it is easy to find visitors who carry out socialization or political negotiations, business transactions, free and fluid discussions of social and cultural issues, as well as those who use coffee shops as a means of releasing congestion and fatigue caused by pressure in the world of work.
The presence of a coffee shop as a means of tudang sipulung for the residents of Makassar city has had an impact on the young people of the city. The coffee shop, which was previously characterized by the majority of visitors from the elderly, has now turned to the young world. Young people as the center of an ideological change, with the presence of coffee shops, slowly but surely have an effect on the increase in consumerism among them. However, the presence of a warung should be seen as something that is beneficial for the social life of the diverse people of Makassar city. Coffee shops should be able to become a means of socio-cultural glue for city residents and a good educational tool for young people.
The rapidly increasing population of Makassar city makes the need for public spaces also increase (Figure 1). This potential seems to be well captured by entrepreneurs by opening a coffee shop. The development of coffee shops in Makassar city is more or less related to the culture of the people of Makassar city. H. Haerullah stated:
The dimensions of change in socio-cultural entities.
Nawi BS, an IT practitioner who sometimes hangs out at a coffee shop 7 days a week, sees:
A coffee shop for coffee connoisseurs is a new public space and social space that allows its visitors to socialize with fellow visitors, both from the community and outside the community. From the habit of visiting coffee shops, coffee shop visitors can make many friends or acquaintances. The intensity of visits to coffee shops is high, making them individuals who are easy to accept new friends. The coffee shop is a unifier in the midst of the diversity of Makassar city residents. For Muhammad Yusuf, this function should receive attention and continue to be developed, as in his following statement:
The improvement of services and facilities provided by coffee shop managers in Makassar city today emphasizes the function of coffee shops as a socio-cultural space for the people of Makassar city. The provision of space with adequate air conditioning facilities makes coffee shops a viable choice for various elements of society. Not infrequently we meet local authorities holding meetings to socialize their programs to both their subordinates and the community or coffee shop community.
In addition to discussions in formal forms that are usually carried out by local authorities and company leaders to their employees. In fact, the discussions that are much livelier are those carried out by various communities at their respective tables. The themes raised as topics of discussion are generally situational, depending on events or social realities currently being hotly discussed by the community at that time.
The phenomenon that is also currently developing towards the use of coffee shop space as a social space is bazaar activities by students, birthdays, and reunions. Ahmad Syamsuddin stated that:
From the observations, it was found data that it is not uncommon for disputes that arise as a result of social or business relationships to be resolved in coffee shops. Which problems like this were previously solved at home or in the office.
The diversity of visitors to coffee shops in Makassar city is so obvious. There are all kinds of people in the coffee shop. Coffee shops do not discriminate between ethnicity, religion, and race, do not differentiate between rank, position, and occupation. All mingle in a coffee shop space that is free, relaxed, relaxed, and fluid. This diversity is one of the attractions for politicians to enliven the coffee shop discussions.
This phenomenon has grown rapidly since the direct election of mayors was held in Makassar, and it has been cultivated by most politicians in Makassar city. There are several forms of activities carried out by politicians in coffee shops, including events that are packaged in the form of talk shows which usually take place in collaboration with radio stations, local newspapers, and coffee shop managers. From the writer\'s observation and involvement in coffee shops during this research, the most common form is the socialization of political actors through photos, posters, and billboards that are often attached to the walls of coffee shops.
Socialization carried out by candidates for rulers or candidates for members of the council, basically got mixed responses for the coffee shop community. For those who are not related to practical politics, the activities carried out by politicians in coffee shops are less effective in influencing the preferences of a voter, as stated by Ahmad Syamsuddin that:
Meanwhile, Muhammad Yusuf saw that the activities of political actors in coffee shops had many benefits. Muhammad Yusuf said that:
In the world of politics, coffee shops provide an adequate contribution to education and information about politics for some residents of Makassar city. This happened because the political discussions both formally and informally were so intense in coffee shops. Socialization is usually done by political figures or authorities in coffee shops can be a source of information and reference for the coffee shop community. Likewise, the socialization carried out by the candidates and their volunteers, who will advance in a contest for the seat of power in Makassar city, becomes material or source of information for the coffee shop community about the current condition of Makassar city. This is possible because, in socialization or imaging like this, most of the actors discuss the current condition of Makassar city and ideas for future improvements. The frequent discussions of this kind in coffee shops are also one of the main attractions as news material for journalists to hang out in coffee shops. So it is no exaggeration if Ahmad Syamsuddin, states that:
One of the clear differences between the coffee shops of the past and the coffee shops of today is adequate facilities for visitors to access information. The coffee shop managers generally provided accessible information facilities, such as television, newspapers, and internet networks. It is from this facility that coffee shop visitors get information. The information obtained is often a hot topic of discussion in coffee shop spaces.
The change in the meaning of traditional coffee shops to modern coffee shops is marked by simple facilities that develop into public spaces equipped with facilities and information such as television, newspapers, and internet networks to meet the needs and satisfaction of visitors.
Coffee shops have become socio-cultural entities in developing patterns of interaction and interrelation as unifiers in association regardless of race, religion, and so on.
Coffee shops have been used as a means of political discussion and self-image, both formally and informally, socializing work programs with political figures or authorities and effectively digging up actual information from visitors.
Today\'s coffee shops have a new entity, namely as a unifier in association regardless of race, ethnicity, religion and as a means of political discussion and self-image, both formally and informally.
The authors declare no conflict of interest.
IntechOpen publishes different types of publications
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On a regional scale, this contribution can be even more significant for many coastal regions. In this chapter, we show that dynamics of small river plumes is significantly different from that of plumes generated by large rivers. Spatial structure of small plumes is generally characterized by sharper horizontal and vertical gradients. As a result, small plumes exhibit more energetic temporal variability in response to external forcing. In this chapter, we address several dynamical features typical for small plumes. We describe and discuss the response of small plumes to wind forcing and river discharge variability, the interaction between neighboring small plumes, and the generation of high-frequency internal waves in coastal ocean by small rivers. We also substantiate the Lagrangian approach to numerical modeling of small river plumes.",book:{id:"8007",slug:"estuaries-and-coastal-zones-dynamics-and-response-to-environmental-changes",title:"Estuaries and Coastal Zones",fullTitle:"Estuaries and Coastal Zones - Dynamics and Response to Environmental Changes"},signatures:"Alexander Osadchiev and Peter Zavialov",authors:[{id:"296909",title:"Prof.",name:"Peter",middleName:null,surname:"Zavialov",slug:"peter-zavialov",fullName:"Peter Zavialov"},{id:"296910",title:"Dr.",name:"Alexander",middleName:null,surname:"Osadchiev",slug:"alexander-osadchiev",fullName:"Alexander Osadchiev"}]},{id:"41072",doi:"10.5772/51864",title:"The November, 1st, 1755 Tsunami in Morocco: Can Numerical Modeling Clarify the Uncertainties of Historical Reports?",slug:"the-november-1st-1755-tsunami-in-morocco-can-numerical-modeling-clarify-the-uncertainties-of-histori",totalDownloads:2396,totalCrossrefCites:4,totalDimensionsCites:10,abstract:null,book:{id:"2221",slug:"tsunami-analysis-of-a-hazard-from-physical-interpretation-to-human-impact",title:"Tsunami - Analysis of a Hazard",fullTitle:"Tsunami - Analysis of a Hazard - From Physical Interpretation to Human Impact"},signatures:"R. 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The study first validated the accuracy of TERRA MODIS SST daytime and nighttime products with the timing SST measurements from the ships in the East China Sea (ECS) in February, May, August and November, 2001, and then the daily variation of daytime and nighttime SST difference was analyzed. Using 16-year MODIS SST monthly products data from February 2000 to January 2016, when all SST monthly products in February, May, August and November were averaged respectively, the seasonal spatial distribution pattern of SST in the ECS was discovered. After monthly sea surface temperature anomaly was finally processed by the empirical orthogonal function (EOF), the interannual variability of SST in the ECS was discussed. The results show that the MODIS SST daily products have a good accuracy with a mean absolute percentage error (MAPE) below 5%. The SST difference between day and night is the largest in winter, followed by spring, then for autumn and the smallest in summer, while the diurnal SST difference is very low for the same season in the different seas. The SST in the ECS displays the obvious seasonal spatial distribution pattern, in which the SST of winter is gradually increasing from north to south, while local temperature difference is the largest for 26.5°C in a year. In comparison, the SST in summer tends uniform and the difference is not more than 5°C in the whole sea. From the EOF analysis of SST anomaly, the interannual variability of SST in the ECS is affected by the East Asian monsoon, the latitudinal difference of solar radiation, the offshore circulation and the submarine terrain.",book:{id:"6195",slug:"sea-level-rise-and-coastal-infrastructure",title:"Sea Level Rise and Coastal Infrastructure",fullTitle:"Sea Level Rise and Coastal Infrastructure"},signatures:"Shaoqi Gong and Kapo Wong",authors:[{id:"219135",title:"Dr.",name:"Shaoqi",middleName:null,surname:"Gong",slug:"shaoqi-gong",fullName:"Shaoqi Gong"},{id:"219138",title:"Mr.",name:"Wong",middleName:null,surname:"Kapo",slug:"wong-kapo",fullName:"Wong Kapo"}]},{id:"63609",doi:"10.5772/intechopen.80903",title:"Saltwater Intrusion in the Changjiang Estuary",slug:"saltwater-intrusion-in-the-changjiang-estuary",totalDownloads:1436,totalCrossrefCites:3,totalDimensionsCites:7,abstract:"Saltwater intrusion in the Changjiang Estuary and the impacts of river discharge, tide, wind, sea level rise, river basin, and major estuary projects on saltwater intrusion are studied in this chapter. There is a net landward flow in the NB (North Branch) when river discharge is low during spring tide, resulting in a type of saltwater intrusion known as the SSO (saltwater-spilling-over from the NB into the SB (South Branch)), which is the most striking characteristic of saltwater intrusion in the estuary. A three-dimension numerical model with HSIMT-TVD advection scheme was developed to study the hydrodynamic processes and saltwater intrusion in the Changjiang Estuary. Saltwater intrusion in the estuary is controlled mainly by river discharge and tide, but is also influenced by wind, sea level rise, river basin, and estuary projects. Saltwater intrusion is enhanced when river discharge decreases. There is more time for the reservoir to take freshwater from the river when river discharge is larger. The fortnightly spring tide generates greater saltwater intrusion than the neap tide. The saltwater intrusion in the SP (South Passage) is stronger than that in the NP (North Passage), and the intrusion in the NP is stronger than that in the NC (North Channel). The northerly wind produces southward currents along the Subei coast as well as the landward Ekman transport, which enhances the saltwater intrusion in the NC and NB and weakens the saltwater intrusion in the NP and SP. Saltwater intrusion becomes stronger as the sea level rises and is much stronger when river discharge is much small. The DWP (Deep Waterway Project) alleviates the saltwater intrusion in the NC and the lower reaches of the NP and enhances the saltwater intrusion in the SP and in the upper reaches of the NP. The Three Gorges Dam (TGD) increases river discharge in winter, which weakens saltwater intrusion, and is favorable for reducing the burden of freshwater supplement in the highly populated estuarine region. The Water Diversion South to the North Project (WDP) decreases river discharge, enhances saltwater intrusion, and is unfavorable for freshwater supply in the estuary.",book:{id:"8669",slug:"coastal-environment-disaster-and-infrastructure-a-case-study-of-china-s-coastline",title:"Coastal Environment, Disaster, and Infrastructure",fullTitle:"Coastal Environment, Disaster, and Infrastructure - A Case Study of China's Coastline"},signatures:"Jianrong Zhu, Hui Wu, Lu Li and Cheng Qiu",authors:[{id:"266207",title:"Dr.",name:"Jianrong",middleName:null,surname:"Zhu",slug:"jianrong-zhu",fullName:"Jianrong Zhu"}]}],mostDownloadedChaptersLast30Days:[{id:"70994",title:"Circulations in the Pearl River Estuary: Observation and Modeling",slug:"circulations-in-the-pearl-river-estuary-observation-and-modeling",totalDownloads:777,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"This chapter reports a cruise survey on the Pearl River Estuary (PRE) and adjacent costal water in the period between May 3, 2014 and May 11, 2014. The circulation and salinity structure were sampled for different tidal phases. With the cruise data, a “sandwich” structure of the lateral salinity distribution and a two-layer structure of longitudinal circulation were identified, together with high variations influenced by wind and tide. Furthermore, longitudinally orientated convergence or divergence of the lateral velocity close to the channel location for certain tidal conditions was observed. The finite volume community ocean model (FVCOM) is configured and run with high spatial resolution of 100 m in the PRE. An atmospheric model, the Weather Research and Forecasting (WRF) Model, is also run to provide high spatial and temporal resolution of atmospheric forcing for the FVCOM. The FVCOM modeling skill assessment is conducted using the cruise salinity and velocity data, as well as water levels, showing that the model can well simulate the velocity and salinity structures. The numerical model reveals that there is a strong neap-spring cycle for the PRE de-tided circulation with 0.37 m s−1 during the neap tide about 42% stronger than that (0.26 m s−1) during the spring tide in the surface layer.",book:{id:"8007",slug:"estuaries-and-coastal-zones-dynamics-and-response-to-environmental-changes",title:"Estuaries and Coastal Zones",fullTitle:"Estuaries and Coastal Zones - Dynamics and Response to Environmental Changes"},signatures:"Jiayi Pan, Wenfeng Lai and Adam Thomas Devlin",authors:[{id:"280757",title:"Dr.",name:"Adam",middleName:"Thomas",surname:"Devlin",slug:"adam-devlin",fullName:"Adam Devlin"},{id:"302219",title:"Associate Prof.",name:"Jiayi",middleName:null,surname:"Pan",slug:"jiayi-pan",fullName:"Jiayi Pan"},{id:"309888",title:"Dr.",name:"Wenfeng",middleName:null,surname:"Lai",slug:"wenfeng-lai",fullName:"Wenfeng Lai"}]},{id:"41072",title:"The November, 1st, 1755 Tsunami in Morocco: Can Numerical Modeling Clarify the Uncertainties of Historical Reports?",slug:"the-november-1st-1755-tsunami-in-morocco-can-numerical-modeling-clarify-the-uncertainties-of-histori",totalDownloads:2396,totalCrossrefCites:4,totalDimensionsCites:10,abstract:null,book:{id:"2221",slug:"tsunami-analysis-of-a-hazard-from-physical-interpretation-to-human-impact",title:"Tsunami - Analysis of a Hazard",fullTitle:"Tsunami - Analysis of a Hazard - From Physical Interpretation to Human Impact"},signatures:"R. Omira, M.A. Baptista, S. Mellas, F. Leone, N. Meschinet de Richemond, B. Zourarah and J-P. Cherel",authors:[{id:"16693",title:"Prof.",name:"Maria Ana",middleName:null,surname:"Baptista",slug:"maria-ana-baptista",fullName:"Maria Ana Baptista"},{id:"16695",title:"Dr.",name:"Rachid",middleName:null,surname:"Omira",slug:"rachid-omira",fullName:"Rachid Omira"},{id:"92702",title:"Prof.",name:"Frederic",middleName:null,surname:"Leone",slug:"frederic-leone",fullName:"Frederic Leone"},{id:"148352",title:"MSc.",name:"Samira",middleName:null,surname:"Mellas",slug:"samira-mellas",fullName:"Samira Mellas"},{id:"148353",title:"Prof.",name:"Bendahou",middleName:null,surname:"Zourarah",slug:"bendahou-zourarah",fullName:"Bendahou Zourarah"},{id:"148356",title:"Prof.",name:"Jean-Philippe",middleName:null,surname:"Cherel",slug:"jean-philippe-cherel",fullName:"Jean-Philippe Cherel"},{id:"157593",title:"Prof.",name:"Nancy",middleName:null,surname:"Meschinet De Richemond",slug:"nancy-meschinet-de-richemond",fullName:"Nancy Meschinet De Richemond"}]},{id:"63921",title:"Eight Types of BG Models and Discretization",slug:"eight-types-of-bg-models-and-discretization",totalDownloads:921,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Eight types of the BG models are introduced in this chapter. The Type 1 is a model using wave parameters at the breaking point. In the Type 2, the effect of longshore sand transport due to the effect of the longshore gradient of breaker height is included with an additional term given by Ozasa and Brampton. In the Type 3, the intensity of sand transport P is assumed to be proportional to the third power of the amplitude of the bottom oscillatory velocity um due to waves, and in the Type 4, P is given by the wave energy dissipation rate due to wave breaking at a local point. In the Type 5, wave power is calculated using the coordinate system different from that for the calculation of beach changes to predict the topographic changes of an island or a cuspate foreland in a shallow water body under the action of waves randomly incident from every direction. In the Type 6, the height of wind waves is predicted using Wilson’s formula using the wind fetch distance and wind velocity, and then sand transport fluxes are calculated. The Type 7 is a model for predicting the formation of the ebb-tidal delta under the combined effect of waves and ebb-tidal currents with an analogy of the velocity distribution of ebb-tidal currents to the wave diffraction coefficient, which can be calculated by the angular spreading method for irregular waves. In the Type 8, the effect of the nearshore currents induced by forced wave breaking is incorporated into the model by calculating the nearshore currents, taking both the wave field and the current velocity at a local point into account.",book:{id:"6012",slug:"morphodynamic-model-for-predicting-beach-changes-based-on-bagnold-s-concept-and-its-applications",title:"Morphodynamic Model for Predicting Beach Changes Based on Bagnold's Concept and Its Applications",fullTitle:"Morphodynamic Model for Predicting Beach Changes Based on Bagnold's Concept and Its Applications"},signatures:"Takaaki Uda, Masumi Serizawa and Shiho Miyahara",authors:[{id:"13491",title:"Dr.",name:"Takaaki",middleName:null,surname:"Uda",slug:"takaaki-uda",fullName:"Takaaki Uda"}]},{id:"57606",title:"Analysis of Dynamic Effects on the Brazilian Vertical Datum",slug:"analysis-of-dynamic-effects-on-the-brazilian-vertical-datum",totalDownloads:950,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"This chapter presents a methodology of analyzing the dynamic effect from mean sea level variations, based on Global Navigation Satellite System (GNSS) data, velocity models, tide gauge observations, and satellite altimetry data. GNSS observations were processed in order to obtain the variation of up coordinate required to identify the possible crust movements. Velocity model served as a comparative basis to verify the obtained results from the GNSS data processing and served as a basis for analyzing the time periods without GNSS information. Tide gauge data were used to evaluate the sea level temporal evolution in the Imbituba Brazilian Vertical Datum (I-BVD). Satellite altimetry data were used for checking the results from the GNSS and the tide gauge time series. The analyses were based on time series of observations by GNSS from 2007 until 2016, tide gauge from 1948 until 1968 and 2001 until 2016, and satellite altimetry data from 1991 until 2015 from different missions. As basis for the analysis, it used GNSS SIRGAS-CON stations, the SIRGAS velocity model (VEMOS), and NUVEL velocity model. Considering the discrimination of the crust vertical movement (GNSS processing) from the results obtained with the tide gauge observations, it was observed that there is an evidence of mean sea level (MSL) rising approximately +2.24 ± 0.4 mm/year.",book:{id:"6195",slug:"sea-level-rise-and-coastal-infrastructure",title:"Sea Level Rise and Coastal Infrastructure",fullTitle:"Sea Level Rise and Coastal Infrastructure"},signatures:"Luciana M. Da Silva, Sílvio R.C. De Freitas and Regiane Dalazoana",authors:[{id:"208387",title:"Dr.",name:"Luciana",middleName:"Maria",surname:"Da Silva",slug:"luciana-da-silva",fullName:"Luciana Da Silva"},{id:"209224",title:"Dr.",name:"Sílvio",middleName:null,surname:"De Freitas",slug:"silvio-de-freitas",fullName:"Sílvio De Freitas"},{id:"209225",title:"Dr.",name:"Regiane",middleName:null,surname:"Dalazoana",slug:"regiane-dalazoana",fullName:"Regiane Dalazoana"}]},{id:"58909",title:"Coastal Disasters and Remote Sensing Monitoring Methods",slug:"coastal-disasters-and-remote-sensing-monitoring-methods",totalDownloads:1106,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Coastal disaster is abnormal changes caused by climate change, human activities, geological movement or natural environment changes. According to formation cause, marine disasters as storm surges, waves, Tsunami coastal erosion, sea-level rise, red tide, seawater intrusion, marine oil spill and soil salinization. Remote sensing technology has real-time and large-area advantages in promoting the monitoring and forecast ability of coastal disaster. Relative to natural disasters, ones caused by human factors are more likely to be monitored and prevented. In this paper, we use several remote sensing methods to monitor or forecast three kinds of coastal disaster cause by human factors including red tide, sea-level rise and oil spilling, and make proposals for infrastructure based on the research results. The chosen method of monitoring red tide by inversing chlorophyll-a concentration is improved OC3M Model, which is more suitable for the coastal zone and higher spatial resolution than the MODIS chlorophyll-a production. We monitor the sea-level rise in coastal zone through coastline changes without artificial modifications. The improved Lagrangian model can simulate the trajectory of oil slick efficiently. Making the infrastructure planning according the coastal disasters and features of coastline contributes to prevent coastal disaster and coastal ecosystem protection. Multi-source remote sensing data can effectively monitor and prevent coastal disaster, and provide planning advices for coastal infrastructure construction.",book:{id:"6195",slug:"sea-level-rise-and-coastal-infrastructure",title:"Sea Level Rise and Coastal Infrastructure",fullTitle:"Sea Level Rise and Coastal Infrastructure"},signatures:"Yan Yu, Shengbo Chen, Tianqi Lu and Siyu Tian",authors:[{id:"162887",title:"Prof.",name:"Shengbo",middleName:null,surname:"Chen",slug:"shengbo-chen",fullName:"Shengbo Chen"},{id:"220026",title:"Dr.",name:"Yan",middleName:null,surname:"Yu",slug:"yan-yu",fullName:"Yan Yu"}]}],onlineFirstChaptersFilter:{topicId:"839",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:10,editor:{id:"38652",title:"Dr.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. 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Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. 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