Project 1 cumulative cost data in euros.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6707",leadTitle:null,fullTitle:"Caesarean Section",title:"Caesarean Section",subtitle:null,reviewType:"peer-reviewed",abstract:"In this book, we present recent advances in surgical techniques as well as the most common perioperative complications in patients that undergo a cesarean section. Moreover, we discuss appropriate measures to reduce unnecessary procedures.",isbn:"978-1-78923-932-4",printIsbn:"978-1-78923-931-7",pdfIsbn:"978-1-83881-661-2",doi:"10.5772/intechopen.72159",price:119,priceEur:129,priceUsd:155,slug:"caesarean-section",numberOfPages:154,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"5efff2e8c75a9e3dc96206b2929c59e7",bookSignature:"Georgios Androutsopoulos",publishedDate:"September 26th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6707.jpg",numberOfDownloads:11296,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:7,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 10th 2017",dateEndSecondStepPublish:"December 1st 2017",dateEndThirdStepPublish:"January 30th 2018",dateEndFourthStepPublish:"April 20th 2018",dateEndFifthStepPublish:"June 19th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"173834",title:"Prof.",name:"Georgios",middleName:null,surname:"Androutsopoulos",slug:"georgios-androutsopoulos",fullName:"Georgios Androutsopoulos",profilePictureURL:"https://mts.intechopen.com/storage/users/173834/images/system/173834.jfif",biography:"Georgios Androutsopoulos completed his Degree in Medicine in 1995, at the National and Kapodestrian University of Athens. \r\nHe received his Medical Specialization in 2006, at the Department of Obstetrics - Gynecology of the University of Patras. He also completed his Doctorate of Medicine 'Pregnancy complications in Greek women with inherited thrombophilia” in 2007, at the same Department.\r\nHe started his clinical career in 1-8-2006, as Obstetrician - Gynecologist at the General, Maternity and Pediatric Hospital of Athens 'Mitera” and he served up until 20-1-2009. In 23-1-2009 he became Consultant of Obstetrics and Gynecology at the General Hospital of Amfissas and he served up until 3-1-2012.\r\nHe started his academic career in 3-1-2012, as Lecturer and Consultant of Obstetrics and Gynecology at the University of Patras and he served up until 20-10-2014. In 20-10-2014, he became Assistant Professor and Consultant of Obstetrics and Gynecology at the same University and holds the position until today. Between 1-11-2016 and 31-10-2017, he was Honorary Clinical Research Fellow in Gynaecological Oncology at Northern Gynaecological Oncology Centre (NGOC), Queen Elizabeth Hospital, Gateshead, United Kingdom. Currently, he is the Head of the Division of Gynecological Oncology of the University of Patras.\r\nHe has got both academic and clinical experience as well as a heavy workload of research and educational duties. Moreover, he has active participation in Medical Students Educational Program as well as in Residency Training Program at the Department of Obstetrics - Gynecology of the University of Patras. His research interests are mainly focused in Gynecological Oncology.\r\nEditor in Scientific Journals: 29.\r\nEditorial Board Member in Scientific Journals: 47.\r\nReviewer in Scientific Journals: 99.\r\nParticipation in Authorship of Scientific Books: 6.\r\nPublications in International Scientific Journals with Reviewers: 82.\r\nPublications in National Scientific Journals with Reviewers: 11.\r\nCitations of Publications: 765.\r\nh-index (Scopus): 6, h-index (Scholar): 13, i10-index (Scholar): 25.",institutionString:"University of Patras",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Patras",institutionURL:null,country:{name:"Greece"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"189",title:"Obstetrics and Gynecology",slug:"obstetrics-and-gynecology"}],chapters:[{id:"63340",title:"Introductory Chapter: Is It Time to Reconsider the Importance of Cesarean Section?",doi:"10.5772/intechopen.80297",slug:"introductory-chapter-is-it-time-to-reconsider-the-importance-of-cesarean-section-",totalDownloads:789,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Georgios Androutsopoulos",downloadPdfUrl:"/chapter/pdf-download/63340",previewPdfUrl:"/chapter/pdf-preview/63340",authors:[{id:"173834",title:"Prof.",name:"Georgios",surname:"Androutsopoulos",slug:"georgios-androutsopoulos",fullName:"Georgios Androutsopoulos"}],corrections:null},{id:"61562",title:"Trends in Cesarean Section",doi:"10.5772/intechopen.77309",slug:"trends-in-cesarean-section",totalDownloads:1174,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Cesarean section (CS) is part of the standard of care in modern obstetrics. Its availability, practicity, high acceptance among patients, and the permanent improvement in surgical techniques, anesthesia, blood replacement, and neonatal care have popularized the procedure as a safe and reasonable alternative to vaginal delivery for any individual born in the twenty-first century. Beyond an established recommended rate of 15% for all births, presently the main challenge in obstetrical care is to limit its use to patients that need the procedure in order to keep an adequate perinatal outcome. The rate of CS has been used in many healthcare settings as an indicator of an individual or institutional obstetrical performance. The issue of overuse of CS as a birth alternative beyond clear maternal or fetal indications has received extensive analysis not only from the reproductive medicine point of view but also from neonatal, ethical, financial, and public health stakeholders. Its place in modern obstetrics, and its impact on short-and long-term maternal and neonatal outcomes, health financial budgets, and in public health policies, have positioned CS a mayor issue to take care of in modern medicine.",signatures:"Andres Sarmiento",downloadPdfUrl:"/chapter/pdf-download/61562",previewPdfUrl:"/chapter/pdf-preview/61562",authors:[{id:"233687",title:"M.D.",name:"Andres",surname:"Sarmiento",slug:"andres-sarmiento",fullName:"Andres Sarmiento"}],corrections:null},{id:"61216",title:"Value of Caesarian Section in HIV-Positive Women",doi:"10.5772/intechopen.76883",slug:"value-of-caesarian-section-in-hiv-positive-women",totalDownloads:948,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The international main goal is to reduce mother-to-child HIV transmission. The appropriate birth delivery for seropositive woman has been analyzed since the beginning of the twenty-first century. Although at the beginning of HIV pandemic delivery by caesarian section (C-section) was considered mandatory in many studies and meta-analyses, recent information reveal limited benefits. Mother-to-child transmission is higher when mothers are diagnosed late during pregnancy, in advanced stages with a high HIV viral load, and labor with membranes ruptured for more than 4 h, especially when the antiretroviral treatment is not respected. During vaginal delivery, the risk of HIV transmitting to infant is due to microtransfusions during uterine contractions or by newborn exposure to cervicovaginal secretions or blood. Although the indication of C-section in HIV-positive women is controversial, there are some situations in which C-section remains mandatory. In mothers diagnosed late during pregnancy, in situation in which HIV viral load is not affordable in real time in the last trimester of pregnancy, and in mothers with poor adherence to antiretroviral treatment, C-section remains one of the most important measures of prevention for HIV mother-to-child transmission.",signatures:"Simona Claudia Cambrea and Anca Daniela Pinzaru",downloadPdfUrl:"/chapter/pdf-download/61216",previewPdfUrl:"/chapter/pdf-preview/61216",authors:[{id:"189887",title:"Associate Prof.",name:"Simona Claudia",surname:"Cambrea",slug:"simona-claudia-cambrea",fullName:"Simona Claudia Cambrea"},{id:"250093",title:"Dr.",name:"Anca Daniela",surname:"Pinzaru",slug:"anca-daniela-pinzaru",fullName:"Anca Daniela Pinzaru"}],corrections:null},{id:"62854",title:"The Surgical Technique of Caesarean Section: What is Evidence Based?",doi:"10.5772/intechopen.78040",slug:"the-surgical-technique-of-caesarean-section-what-is-evidence-based-",totalDownloads:2460,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Caesarean section is the most frequent obstetric operation which is associated with increased maternal morbidity and mortality. Although these risks are low, affected women may suffer from severe consequences and this may affect subsequent pregnancies and deliveries. A variety of surgical approaches have been described, however, on low evidence level. The objective of this chapter is therefore to systematically search the literature and analyse the available evidence including preoperative workup, prophylactic antibiotics, skin disinfection, preoperative bladder catheterization as well as details of the individual steps of the actual operation itself such as skin incision types, preparation of soft tissue and womb, removal of the placenta, cervical dilatation and stitching of the womb, peritoneum, rectus muscle, fascia, subcutaneous fat, and skin. We systematically searched for meta-analysis, systematic reviews, and big studies and evaluated the evidence for each individual step.",signatures:"Jan-Simon Lanowski and Constantin S. von Kaisenberg",downloadPdfUrl:"/chapter/pdf-download/62854",previewPdfUrl:"/chapter/pdf-preview/62854",authors:[{id:"100660",title:"Prof.",name:"Constantin",surname:"Von Kaisenberg",slug:"constantin-von-kaisenberg",fullName:"Constantin Von Kaisenberg"},{id:"240353",title:"Dr.",name:"Jan-Simon",surname:"Lanowski",slug:"jan-simon-lanowski",fullName:"Jan-Simon Lanowski"}],corrections:null},{id:"60123",title:"Pros and Cons of Myomectomy during Cesarean Section",doi:"10.5772/intechopen.75365",slug:"pros-and-cons-of-myomectomy-during-cesarean-section",totalDownloads:1358,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Additional surgical interventions apart from emergencies during cesarean section are not recommended in the textbooks; thus, surgical procedures like myomectomy as an adjunct to cesarean section remains a hot topic of discussion. There are many publications supporting serosal myomectomy during cesarean section, but studies published so far are poor in quality of evidence. To clarify the efficacy and safety of cesarean myomectomy, large-scale randomized controlled studies and studies explaining the mid-term and long-term outcomes of the cesarean myomectomy are required. Traditionally, cesarean myomectomy is performed from the uterine serosa as in the usual abdominal myomectomy. Although the surgical technique is the same as intracapsular myomectomy, a novel cesarean myomectomy technique, endometrial myomectomy, introduced into the obstetrics practice for minimizing the risk of adhesion formation and diminishing the blood loss during surgery. Further, strong studies are needed to overcome the controversy on cesarean myomectomy.",signatures:"Cengiz Tokgöz, Şafak Hatirnaz and Oğuz Güler",downloadPdfUrl:"/chapter/pdf-download/60123",previewPdfUrl:"/chapter/pdf-preview/60123",authors:[{id:"235275",title:"M.D.",name:"Şafak",surname:"Hatırnaz",slug:"safak-hatirnaz",fullName:"Şafak Hatırnaz"},{id:"240855",title:"Dr.",name:"Cengiz",surname:"Tokgöz",slug:"cengiz-tokgoz",fullName:"Cengiz Tokgöz"},{id:"240856",title:"Dr.",name:"Oğuz",surname:"Güler",slug:"oguz-guler",fullName:"Oğuz Güler"}],corrections:null},{id:"60912",title:"Complications of Cesarean Operation",doi:"10.5772/intechopen.75901",slug:"complications-of-cesarean-operation",totalDownloads:1402,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In the last decades, there has been a huge increase in the incidence of the cesarean section that worldwide became a routine procedure in most hospitals despite the potential complications which in some cases can cause permanent damage or can even be fatal, affecting both the mother and the fetus. In this chapter, we will discuss the most frequent complications that occur in the cesarean section both in the surgical act and after the event.",signatures:"Enrique Rosales Aujang",downloadPdfUrl:"/chapter/pdf-download/60912",previewPdfUrl:"/chapter/pdf-preview/60912",authors:[{id:"237635",title:"Dr.",name:"Enrique",surname:"Rosales",slug:"enrique-rosales",fullName:"Enrique Rosales"}],corrections:null},{id:"63427",title:"Caesarean Section: Reasons for and Actions to Prevent Unnecessary Caesareans",doi:"10.5772/intechopen.76582",slug:"caesarean-section-reasons-for-and-actions-to-prevent-unnecessary-caesareans",totalDownloads:1223,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"According to data from 150 countries, the worldwide caesarean section rate increased from 7% in 1990 to 19% in 2014. Latin America and the Caribbean region reported the highest CS rate 42%, followed by North America 32%, Oceania 31%, Europe 25%, Asia 19%, and Africa 7%. This trend is accompanied by increasing reports of severe adverse outcomes, such as invasive placenta, peripartum hysterectomy, and massive obstetric bleeding. The World Health Organization stated in 2015 that caesareans are effective in saving maternal and infant lives only when they are required for medically indicated reasons and that caesarean rates higher than 10–15% at a population level are not associated with reduced maternal or newborn mortality rates. More than 90% of women claim that they want to give birth in a natural way. In contrast, recent studies suggest that the majority of planned caesareans are carried out for psychosocial or nonmedical reasons. Knowledge about the indications for caesareans is a prerequisite in order to define actions to prevent unnecessary caesareans. The aim of this chapter was to present a review of the history behind, and to evaluate the indications for, caesarean sections in order to suggest appropriate actions to prevent unnecessary caesareans.",signatures:"Ylva Vladic Stjernholm",downloadPdfUrl:"/chapter/pdf-download/63427",previewPdfUrl:"/chapter/pdf-preview/63427",authors:[{id:"238942",title:"Associate Prof.",name:"Ylva",surname:"Vladic Stjernholm",slug:"ylva-vladic-stjernholm",fullName:"Ylva Vladic Stjernholm"}],corrections:null},{id:"62348",title:"Improving Obstetrical Outcomes in Cesarean Sections, by Utilizing Evidence-Based Strategies",doi:"10.5772/intechopen.78667",slug:"improving-obstetrical-outcomes-in-cesarean-sections-by-utilizing-evidence-based-strategies",totalDownloads:959,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cesarean sections are the most commonly performed surgery in the USA. Changing policies and clinical information have resulted in improved outcomes for both mothers and babies. We describe evidence-based best practices for a multi-strategy approach to reduce cesarean section rates, increasing safety and success of vaginal births after cesarean section, decreasing complication rates in higher order cesarean sections, and accurate estimations of blood loss. In addition, we present a novel approach of utilizing venous lactate levels to identify the need for blood transfusions in the resuscitation of women with postpartum hemorrhage. Given that pregnancy is a life event, we describe increased self-reported stress levels in women during pregnancy and after the birth. In summary, adoption of the best practices outlined herein will greatly enhance the safe practice of cesarean sections.",signatures:"Donald Morrish and Iffath A. Hoskins",downloadPdfUrl:"/chapter/pdf-download/62348",previewPdfUrl:"/chapter/pdf-preview/62348",authors:[{id:"235201",title:"Dr.",name:"Iffath",surname:"Hoskins",slug:"iffath-hoskins",fullName:"Iffath Hoskins"},{id:"236201",title:"Dr.",name:"Donald",surname:"Morrish",slug:"donald-morrish",fullName:"Donald Morrish"}],corrections:null},{id:"60224",title:"Vaginal Delivery after Cesarean Section",doi:"10.5772/intechopen.75900",slug:"vaginal-delivery-after-cesarean-section",totalDownloads:992,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cesarean delivery is needed (indicated) for many reasons such as failure to progress, cephalopelvic disproportion, antepartum hemorrhage, preeclampsia, and repeated cesareans. The increase of the cesarean delivery rate is accompanied with an increase in the maternal and perinatal morbidities and increase in maternal mortality such as complications of anesthesia, injury to the nearby structure, respiratory distress syndrome, childhood allergy and childhood obesity. Vaginal delivery after cesarean section (VBAC) is one of the tools that aimed to reduce the rate of cesarean delivery. Here in this chapter we would like to highlight the different guidelines for VBAC, the success rate of VBAC, the determinant of the success rate, maternal and perinatal outcomes of VBAC. Then the arena of using oxytocic drugs in VBAC is discussed in details too.",signatures:"Zaheera Saadia, Nadiah AlHabardi and Ishag Adam",downloadPdfUrl:"/chapter/pdf-download/60224",previewPdfUrl:"/chapter/pdf-preview/60224",authors:[{id:"180747",title:"Prof.",name:"Ishag",surname:"Adam",slug:"ishag-adam",fullName:"Ishag Adam"},{id:"242606",title:"Dr.",name:"Zaheera",surname:"Saadia",slug:"zaheera-saadia",fullName:"Zaheera Saadia"},{id:"242607",title:"Dr.",name:"Nadiah",surname:"AlHabardi",slug:"nadiah-alhabardi",fullName:"Nadiah AlHabardi"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6191",title:"Selected Topics in Breastfeeding",subtitle:null,isOpenForSubmission:!1,hash:"3334b831761ffa52e78de6fc681e33b3",slug:"selected-topics-in-breastfeeding",bookSignature:"R. Mauricio Barría P.",coverURL:"https://cdn.intechopen.com/books/images_new/6191.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10460",title:"Current Topics in Caesarean Section",subtitle:null,isOpenForSubmission:!1,hash:"e59550fca39fd09ff4addfe39ca822a0",slug:"current-topics-in-caesarean-section",bookSignature:"Panagiotis Tsikouras, Nikolaos Nikolettos, Werner Rath and Georg Friedrich Von Tempelhoff",coverURL:"https://cdn.intechopen.com/books/images_new/10460.jpg",editedByType:"Edited by",editors:[{id:"48837",title:"Prof.",name:"Panagiotis",surname:"Tsikouras",slug:"panagiotis-tsikouras",fullName:"Panagiotis Tsikouras"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8557",title:"Empowering Midwives and Obstetric Nurses",subtitle:null,isOpenForSubmission:!1,hash:"c6d90f0978fbce94e13061740cb1d4bc",slug:"empowering-midwives-and-obstetric-nurses",bookSignature:"Amita Ray",coverURL:"https://cdn.intechopen.com/books/images_new/8557.jpg",editedByType:"Edited by",editors:[{id:"251100",title:"Prof.",name:"Amita",surname:"Ray",slug:"amita-ray",fullName:"Amita Ray"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10929",title:"The Gynecological Papyrus Kahun",subtitle:null,isOpenForSubmission:!1,hash:"b8818312089bdfb0423707a231e104d8",slug:"the-gynecological-papyrus-kahun",bookSignature:"Helena Trindade Lopes and Ronaldo G. 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In 2010, he received a Ph.D. in Egyptology from the University of Basel, Switzerland.\nFrom 2012 to 2017, Dr. Pereira was a post-doctoral fellow at CHAM/FCSH – Universidade Nova de Lisboa.\nIn 2018, he became an Onassis Fellow, hosted by the Department of Mediterranean Studies, University of the Aegean, Greece. \nIn 2019, he became an auxiliary researcher at CHAM/FCSH – Universidade Nova de Lisboa. 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The first practice to control a project is just checking the financial reporting and therefore the project control is only based on the cost control (budgeted versus actual incurred cost). But the experience, especially from projects that failed, shows that a more efficient project management requires controlling also the project performance and scheduling besides the cost.
The Earned Value Management (EVM) is a methodology that integrates the management of project scope, schedule and cost. It has been widely and successfully used for over 40 years and it should apply to any project, large or small, at any industry. The interest about the EVM has increased in the last ten years and a substantial amount of research has been carried out regarding the EVM, generating new extensions of the methodology and specific applications. In parallel, many guidelines and rules have been published to implement properly the EVM, coming mainly from the U.S. Government who originally developed the EVM, but not only, because also the ANSI organization has established a standard defining the EVM.
The contribution of this work is twofold. First of all, it aims to identify the principal lines of research in the project management control using earned value management across the academic research and organizations practice. Following, the attention is focused on the characteristics of one of these research lines, the PBEV. This extension pretends to be not only an EVM parameters enhancement but a complete managing system based on the technical performance, which could be a useful EVM improvement to be used in engines engineering projects where the technical objectives are the main target. Secondly, it lies in the intention of this work to evaluate the applicability and the efficiency of the PBEV with two case studies of two real-life engineering projects of combustion engines development for energy generation applications.
Basically, the EVM requires a fixed point-of-reference, given by the project baseline schedule and the budget at completion (BAC), in order to periodically measure the project performance along the life of the project. Project performance, both in terms of time and costs, is determined by comparing the three key parameters of the EVM, planned value (PV), actual costs (AC) and earned value (EV), resulting in performance variances known as schedule variance (SV=EV-PV) and cost variance (CV=EV-AC) and performance indexes as the schedule performance index (SPI=EV/PV) and the cost performance index (CPI=EV/AC). See [4] and [5]. Figure 1 shows the EVM key parameters.
EVM key parameters.
For a better understanding of the state of the art of the EVM it is necessary to know its origins, widely commented in [1] and [2], and the official sources of EVM guidelines and standards.
The earned value concept originally came from industrial engineers in factories in the early 1900s who for years have employed a three-dimensional approach to assess true “cost-performance” efficiencies. To assess their cost performance, they compared their earned standards (the physical factory output) against the actual cost incurred. Then, they compared their earned standards to the original planned standards (the physical work they planned to accomplish) to assess the schedule results. These efforts provided earned value in its most basic form. Most important, the industrial engineers defined a cost variance as the difference between the actual costs spent and the earned standards in the factory. This definition of a cost variance is perhaps the indication to determine whether one uses the earned-value concept. Later on, in 1965 the United States Air force acquisition managers defined 35 criteria which capture the essence of earned value management. Two years later the U.S. Department of Defense (DoD) adopted these same criteria as part of their Cost/Schedule Control Systems Criteria (C/SCSC). Then, in 1996, after a rewrite of the C/SCSC 35 criteria by private industry, the DoD accepted the rewording of this criteria under a new title called Earned Value Management System (EVMS), and the total number of criteria was reduced to 32. In 1998, National Defense Industrial Association (NDIA) obtained acceptance of the Earned Value Management System in the form of the American National Standards Institute, termed the ANSI/EIA-748 Standard, see [3]. From this on, many research lines have been developed trying to improve the EVM, and they are commented in the following point.
As mentioned in the introduction, the use of EVM and parts of it, or tailoring it to specific situations continue to grow and a substantial amount of research is being carried out. The main investigations could be grouped at least in six big research lines as follows.
EVM and fuzzy determination of EV. One of the major difficulties in the determination of EV is the evaluation of in-process work. There are some techniques to quantify the accomplished work and some of them propose fuzzy techniques. As explained in [6] and [7].
EVM forecast accuracy. Some studies about EVM are focusing on the improvement of the accuracy of EVM to calculate forecasts of project cost and schedule at completion. See references [8], [9] and [10]
EVM and Earned Schedule. Another object of studies is an enhancement to Earned Value Management, called Earned Schedule that appeared in 2003. This method propose the parameters of the EVM in terms of time instead of cost, and it could be postulated to give more forecasting accuracy in the latest stages of the project. See [11]. The author of this research line criticized the use of the classic SV and SPI metrics since they give false and unreliable time forecasts near the end of the project. Instead, he provided a time-based measure to overcome this unreliable behavior of the SV and SPI indicators. This earned schedule method relies on similar principles than the earned value method, but translates the monetary metrics into a time dimension. He reformulated the time performance measures SV and SPI to SV(t) and SPI(t) (where the t between brackets is used to distinguish with the original performance measures) and has shown that they have a reliable behavior along the whole life of the project. Since its introduction, a considerable stream of publications on the project time performance measurement and/or the earned schedule concept has been published in the academic literature. Statistical validation of the time performance indicators and stability studies on empirical data can be found in [12].
EVM to integrate risk management. There are project tools for risk analysis mainly focused on network based techniques, such as, CPM (Critical Path Method) and PERT (Program Evaluation and Review Technique) and others based in statistical probabilities like Montecarlo Simulations. Nevertheless, EVM contains no guidelines on risk management. Therefore, some investigations are conducting to integrate risk analysis in the EVM. First, including risk management activities in the WBS (Work Breakdown Structure) and second considering that Estimated at Completion (EAC) should be based on both project performance and quantified risk assessments. Other investigations try to combine the risk analysis tool results, for example Montecarlo simulations, with EVM metrics. See [13].
EVM to integrate quality. The quality of the product must be tracked in an engineering project to evaluate the success or failure of the product. Some studies are proposing to apply a quality factor to the EV, such as, reducing the EV when poor quality occurs. See [14].
EVM to integrate technical performance. In engineering projects not only cost and schedule must be tracked but also the technical performance. Further investigations are being done to integrate technical requirements accomplishment with EVM. One proposal is an EVM extension called Performed-Based Earned Value (PBEV). See [15-18].
This last extension of the EVM integrating the technical performance, the PBEV, will be deeply analyzed in the following points due to it is not only a new manner of measuring the earned value but it is an entire management system which include concepts and procedures to manage the technical issues that could enhance the engineering projects in general. Therefore, it will be studied its suitability to engine engineering projects.
EVM evolution and research lines.
The Performance Based Earned Value (PBEV) is an enhancement to the EVM standard that overcomes the standard´s shortcomings with regard to measuring technical performance and quality because it is based on standards and models for systems engineering, software engineering, and project management. The distinguishing feature of PBEV is its focus on the customer requirements. PBEV provides principles and guidance for cost effective processes that specify the most effective measures of cost, schedule, and product quality performance.
The PBEV has been formulated by the author Paul J. Solomon, see [16], whom experience at programs management and concretely with the EMVS explains the origin of the PBEV. Solomon manages the EVM for Northrop Grumman Corporation, Integrated Systems and he has participated in programs for the U.S. Government as the B-2 Bomber, Global Hawk and F-35 Joint Strike Fighter. He is on the board of the National Defense Industrial Association, Program Management Systems Subcommittee that authored ANSI/EIA-748.
The cancellation of the US Navy’s A-12 Avenger stealth aircraft program in January 1991 resulted in research during the 1990s, which investigated the reliability of EVM cost prediction and the project management failures in accurately reporting project performance, using U.S. Department of Defense (DOD) project data. These research findings have come to be regarded as generally applicable across all project types using EVM across multiple industry sectors. The U.S. Government Accountability Office (GAO), for example, studied failures in acquisition of weapons systems and information technology systems. Some report of the GAO concluded that DOD paid billions in award and incentive fees regardless the contractors not held cost goals, schedule goals and the program did not capture early on the warnings needed to effectively manage program risk. The GAO concluded that, if EVM is not properly implemented, the data may be inaccurate and misleading.
The EVM standard, which is formulated in the ANSI/EIA Standard-748-A-1998, has significant shortcomings with regard to measuring technical performance and quality. First, the EVMS standard states that EV is a measurement of the quantity of work accomplished and that the quality and technical content of work performed are controlled by other processes. A program manager should ensure that EV is also a measurement of the product quality and technical maturity of the evolving work products instead of just the quantity of work accomplished. Second, the EVMS principles address only the project work scope. EVMS ignores the product scope and product requirements. Third, EVM is perceived to be a risk management tool. However, EVMS was not designed to manage risk and does not even mention the subject.
Thus, the EVM will provide more reliable information for analysis and decision-making if the EVM guidelines are augmented by guidance regarding maintaining the technical baseline, measuring technical performance, and managing risk.
Most of the guidelines and best practices for planning and measuring the technical performance considering also the EVM are provided by two sources: the U.S. Department of Defense (DOD) and some industrial standards.
First of this sources, the U.S. DOD, issued an acquisition policy which states that programs implement Systems Engineering Plans (SEP). DOD also published guides to implement the policy, such as:
The Defense Acquisition Guidebook (DAG).
The Systems Engineering Plan Preparation Guide (SEPPG).
The Work Breakdown Structure Handbook (MIL-HDBK-881A (WBS))
The Integrated Master Plan (IMP).
The Integrated Master Schedule (IMS) Preparation and Use Guide.
The DOD guides refer also to EVMS. See [19].
These guides show the enormous importance that the U.S. DOD gives to measuring technical performance, hence, according to U.S. DOD it should be one of the parameters to control during project progress. See [20] and [21].
The second source of guidelines for planning and measuring the technical performance are some industry and professional standards, that have been incorporating the technical performance accomplishment for the project control and they have been at the same time sources themselves for defining the DOD policy, as well as:
The Institute of Electrical and Electronics Engineers (IEEE) 1220.
EIA 632.
“A Guide to the Project Management Body of Knowledge” (PMBOK). See [22] and [23].
Capability Maturity Model Integration (CMMI). See [24].
In the following points are explained the main concepts defined by the U.S. DOD guidelines and the industrial standards that are used by the PBEV. Figure 3 shows the guidelines and standards and their sources for technical performance treatment at projects.
Guidelines and standards to manage technical performance.
The PBEV is a set of principles and guidelines that specify the most effective measures of cost, schedule, and product quality performance. It has several characteristics that distinguish it from standard EVMS:
Plan is driven by product quality requirements, not work requirements.
Focuses on technical maturity and quality, in addition to work.
Focuses on progress toward meeting success criteria of technical reviews.
Adheres to standards and models for SE, software engineering, and project management.
Provides smart work package planning.
Enables insightful variance analysis.
Ensures a lean and cost-effective approach.
Enables scalable scope and complexity depending on risk.
Integrates risk management activities with the performance measurement baseline.
Integrates risk management outcomes with the Estimate at Completion.
PBEV augments EVMS with 4 additional principles and 16 guidelines. The following are PBEV principles that set it apart from EVMS:
Product scope and quality. Integrate product scope and quality requirements into the performance measurement baseline. This principle focuses on customer satisfaction, which is based on delivery of a product that meets its quality requirements and is within the cost and schedule objectives.
Product quality requirements. Specify performance toward satisfying product quality requirements as a base measure of earned value. A product quality requirement is a characteristic of a product that is mandatory in order for the product to meet verified customer needs.
Risk management integration. Integrate risk management with EVM.
Tailor PBEV. Tailor the application of PBEV according to the risk.
And the PBEV guidelines are listed following.
Establish product quality requirements and allocate these to product components.
Maintain bidirectional traceability of product and product component quality requirements among the project plans, work packages, planning packages, and work products.
Identify changes that need to be made to the project plans, work packages, planning packages, and work products resulting from changes to the products quality requirements.
Define the information need and objective to measure progress toward satisfying product quality requirements.
Specify work products and performance-based measures of progress for satisfying product quality requirements as base measures of earned value.
Specify operational definitions for the base measures of earned value, stated in precise, unambiguous terms that address communication and repeatability.
Identify event-based success criteria for technical reviews that include development maturity to date and the products´s ability to satisfy product quality requirements.
Establish time-phased planned values for measures of progress toward meeting product quality requirements, dates of frequency for checking progress, and dates when full conformance will be met.
Allocate budget in discrete work packages to measures of progress toward meeting product quality requirements.
Compare the amount of planned budget and the amount of budget earned for achieving progress toward meeting product quality requirements.
Use Level of Effort method to plan work that is measurable, but is not a measure of progress toward satisfying product quality requirements, final cost objectives, or final schedule objectives
Perform more effective variance analysis by segregating discrete effort from Level of Effort.
Identify changes that need to be made to the project plans, work packages, planning packages, and work products resulting from responses to risks.
Develop revised estimates of costs at completion based on risk quantification.
Apply PBEV coverage to the whole work breakdown structure or just to the higher risk components.
Apply PBEV throughout the whole system development life cycle or initiate after requirements development.
The PBEV feeds on concepts from the U.S. DOD guidelines and industrial standards mentioned above. In the following points are explained in detail the main concepts used in the PBEV coming from those sources, such as, the Systems Engineering Plan (SEP), the products metrics and quality, the success criteria, the Technical Performance Measurements (TPM) and Capability Maturity Model Integration (CMMI). The concepts that feed the PBEV are shown in figure 4.
The concepts that feeds the PBEV
Systems Engineering Plan (SEP)
The purpose of the Systems Engineering Plan (SEP) is to help programs develop their Systems Engineering (SE) approach, providing a firm and well-documented technical foundation for the program. The SEP is a living document in which periodic updates capture the program’s current status and evolving SE implementation and its relationship with the overall program management effort. Although the detailed content of each SEP is customized according to the particulars of a program and each update may vary depending on the program’s acquisition phase, using a common framework encourages sound technical planning throughout the program’s life cycle. The emphasis should be on the rigor of the technical planning as captured in the SEP, not on the SEP itself. The SEP also serves as a common reference to achieve shared stakeholder insight regarding a program’s planned technical approach. It provides a documented understanding of how the program will accommodate cost, schedule, performance, and sustainment trades; the expected products of the SE effort; and how these products will contribute to program decision making.
Products metrics and quality
The IEEE 1220 and the EIA 632 have similar guidance regarding product metrics and quality. Product metrics allow assessment of the product´s ability to satisfy requirements and to evaluate the evolving product quality against planned or expected values. Of equal importance are a disciplined requirements traceability process and a requirements traceability database.
Success criteria
The standards discuss the importance of holding technical reviews at various stages of development to assure that all success criteria have been met. IEEE 1220 provides success criteria to be used at major technical reviews. For example some of the success criteria for a preliminary design review are the following:
Prior completion of subsystem reviews.
Determine whether total system approach to detailed design satisfies the system baseline.
Unacceptable risks are mitigated.
Issues for all subsystems, products, and life-cycle processes are resolved.
The success criteria should be defined in a SEP or other technical plan. The customer should review this plan with the supplier and reach agreement on the success criteria to be used at technical reviews.
Technical Performance Measurement (TPM)
Technical Performance Measurement (TPM) are defined and evaluated to assess how well a system is achieving its performance requirements. TPM uses actual or predicted values from engineering measurements, test, experiments, or prototypes. IEEE 1220, EIA 632 and “A Guide to the Project Management Body of Knowledge” (PMBOK guide) provide similar guidance for TPM planning and measurement and for integrating TPM and EVM.
Capability Maturity Model Integration (CMMI)
The CMMI provides many practices that augment the EVMS guidelines. CMMI also lists Typical Work Products (TWPs) within process areas. To ensure traceability of product quality requirements to work tasks and work products, these TWPs, or similar artifacts, should be the outcome of work packages. Here are some TWPs in CMMI.
TWPs include the following:
Product-component requirements.
Activities diagrams and use cases.
Verification criteria used to ensure requirements have been achieved.
Exit and entry criteria for work products.
Following are listed the advantages and disadvantages of the PBEV that it has been used also in the following case studies analyzed during this work.
The main PBEV pros are:
It integrates effectively the technical performance with the cost and schedule control.
It collects the best practices of the U.S. DOD guides and industry and professional standards related with project management and then apply the EVM.
It is based on client or product requirements.
By the other hand, the PBEV could have the following cons:
It gives a very large methodology to implement to be able to integrate the technical performance in the project management control but there is no mention to any parameter, or metric definition to implement easily that allows calculating EVM variances or indexes with results of technical performance status.
It only influences somehow the work breakdown structure but not the EVM metrics.
The customer should review the SE plan with the supplier and reach agreement on the success criteria to be used at technical reviews. It would be more objective to define a technical parameter to evaluate success criteria, as for example, the strength safety margin of a mechanical part.
They have been performed two case studies of the applicability and the efficiency of the EVM standard and one of its extensions, the PBEV which is based on technical performance, for the engines engineering projects control in the energy field.
They have been analyzed two real-life projects of engine engineering in the energy field performed between 2004 and 2005 by a company dedicated to the development and manufacturing of combustion engines for power generation.
These projects are characterized by including the typical phases of the industrial engineering projects, such as, the concept design phase, detailed design phase, simulation, prototyping, testing and launch mass production, where the level of compliance of the technical objectives is strongly important besides the cost and scheduling control. The two projects analyzed are also featured by the fact that they are large projects in the energy field as they have budgets of several million euros, durations between 2-4 years and the risk of developing new products for the market. The large size of the projects makes the breakdown structure of the tasks (WBS) to be also quite large. Another property that characterizes these two projects, and in general all the engine development projects in the energy field, is that they are pretty similar to engine development projects in the automotive field since the product is similar. Therefore, the engines made for energy field are fed with many of the technologies used in automotive field, as well as, with the methodologies and requirements to create new products that meet the market requirements. The competitiveness for obtain improved technical results makes that in both, energy projects and automotive projects, the technical objectives are a critical parameter to control for the project, just with the costs and the schedule. Hence, the PBEV could be a suitable and useful tool for integrating scope, schedule, cost and technical performance in these projects. Moreover, in both fields, energy and automotive, the continuous technology evolution makes the technical objectives to be overpassed from one project to the following. For that reason is a real-life practice in these fields that at new product development projects, with the existing technology in that moment, that, if the technical objectives are not met but they are inside of an allowable range, the project could be accepted with penalties.
In summary, the projects analyzed with PBEV are characterized for being classical industrial engineering projects with large size of the WBS, also for having the technical performance as a key parameter to control where the technical objective could be in a range of tolerance for accept the successful of the project. The project number 1 consists on the development of a new engine of higher efficiency and power than the existing ones in the company and the project number 2 was dedicated to development a new injection system for the current engines. Figure 5 shows the type of engine developed in project 1 and 2.
Type of projects analysed: engine engineering projects
The project 1 began in January 2004 and was delayed one year by material procurement problems but once they were negotiated new deadlines with suppliers in 2005 was launched again and began an overall tracking of the technical targets, cost and schedule. In this project, the engineering consultancy delivered a design that was slightly below the technical targets of engine performance and efficiency, which was penalized in his fees. The engine efficiency target was 42% but an engine with 40% was obtained. Finally, the project was completed in January 2008, bringing to the market the new engine with a very good acceptance and overall rating of satisfactory.
Regarding the project 2, it began also in 2005 and although the design and material procurement were on time, the project turned 180º in 2007 when it was found that to accomplish the technical targets of the new injection system it was necessary to implement a technology 10 times more expensive than originally planned. This event made management direction to stop the project after making a rough estimation of the overall cost of the project with the implementation of the new technology.
From these two project data, here is proposed to apply the PBEV to analyze if it is possible to report the status of the project in time, cost and technical compliance, to predict future states.
In the two projects analyzed the available information during the duration of all the project was the following documents and reports.
A project specification document which collects all the technical specifications to meet with contractual nature.
A Statement Of Work (SOW) document which collects the definition of all the tasks to be performed in the project and has contractual nature.
The initial baseline schedule in an MS project file. It is detailed with several tasks levels and including the starting and finishing dates, as well as, the dependences between them.
The total budget of the project made at the beginning of the project and broken down in general spending issues. The general spending issues are the following six: material costs, the tooling investments, engineering hours, outsourcing expert consultancy support hours, testing costs, and trips. Intermediate budget estimation was not performed during the project progress.
The general accounting of the project with the invoiced costs per month. They are available the figures of monthly costs of the general issues.
A monthly report with the technical, economical and scheduling tracing. The technical part of the report included a list of all manufacturing drawings and the testing results. Figure 6 shows engine control units screen where technical parameters are monitored, as for example, the engine performance. These technical values are the reference to check the technical accomplishment. The economical part of the report included cost monthly figures of the general spending issues collected from the invoices. The scheduling part of the report included approximate deadlines for the critical tasks but not a detailed scheduling track.
Engine control unit monitoring engine performance
Due to fact that the available data in the two projects analyzed are the initial budget, accumulated costs and the engineering hours accumulated only for the higher level of the WBS, the EVM is applied only at this top level. This way of controlling is called top-down project control. According to reference [13], the EVM offers calculation methods yielding reliable results on higher WBS levels, which greatly simplify final duration and completion date forecasting. These early warning signals, if analyzed properly, define the need to eventually go down into lower WBS levels when action thresholds are exceeded. In conjunction with the project schedule, it allows taking corrective actions on those activities which are in trouble (especially those tasks which are on the critical path).
The methodology used to implement the EVM based on technical performance in the two projects under study has two steps. The first step is to apply the EVM standard and check if the results are consistent. The second step is to apply the PBEV through the use of penalties in the obtained EV when the technical requirements are not met and check if the results are consistent with the reality of the project. An objectively way of establish the penalties depends on the technical parameter selected to control and on the technical performance measurement, therefore, it depends on the internal mechanisms of each company to evaluate the objectives compliance as explained in reference [16].
To carry on the first step, this is to apply the EVM standard on the two projects, from the available data, one begins by determining the values of the three basic parameters of the EVM, and this is, PV, AC and EV. Because PV is not available monthly, it is considered the hypothesis of distributing uniformly the initial budget between the months of the project, and then the PV accumulated is lineal. The figures of the monthly AC are available in the project data. Finally, to calculate the EV, the engineering hours performed are taken as the indicator of work accomplished. And from the 3 basic parameters they are calculated the Cost and Schedule Variances (CV and SV) and the Cost and Schedule Performance Indices (CPI and SPI) to check if the results of de EVM are consistent.
To implement the second step, this is to calculate the PBEV, a reduction of the EV is applied in the monthly work accomplished when the technical objectives are not met, so in this way it is shown that the project is farther from the objectives and then from finish than planned.
Methodology to apply PBEV to engine engineering projects.
The two case studies carried out with engine engineering projects have been raised as a series of research questions to be answered in order to draw conclusions. The research questions are the following:
Q1: Is it possible to apply the EVM standard to engines engineering projects only with the data that is usually controlled in such projects?
Q2: Is it possible to apply the PBEV to engines engineering projects?
Q3: Does the PBEV capture the real project progress in engines engineering projects with only the project information available?
Q4: Is it useful the information resulting from the PBEV to take decisions in the engine engineering projects?
In this point are summarized the two case studies results. Table 2 shows the project 1 cumulative cost data. The Budget At Completion (BAC) for project 1 was 2.427.950 euros. The costs and BAC are used as input to calculate the EVM and the PBEV parameters which are shown in table 2.
\n\t\t\t\t | \n\t\t|||||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t416.686 | \n\t\t\t444.229 | \n\t\t\t445.059 | \n\t\t\t471.645 | \n\t\t\t472.736 | \n\t\t
\n\t\t\t\t | \n\t\t\t279.356 | \n\t\t\t279.356 | \n\t\t\t279.356 | \n\t\t\t279.356 | \n\t\t\t279.356 | \n\t\t
\n\t\t\t\t | \n\t\t\t308.880 | \n\t\t\t400.650 | \n\t\t\t424.890 | \n\t\t\t474.750 | \n\t\t\t487.560 | \n\t\t
\n\t\t\t\t | \n\t\t\t2.935 | \n\t\t\t4.036 | \n\t\t\t4.353 | \n\t\t\t4.688 | \n\t\t\t4.688 | \n\t\t
\n\t\t\t\t | \n\t\t\t1.443.296 | \n\t\t\t1.522.324 | \n\t\t\t1.522.605 | \n\t\t\t1.526.015 | \n\t\t\t1.526.015 | \n\t\t
\n\t\t\t\t | \n\t\t\t13.021 | \n\t\t\t16.435 | \n\t\t\t16.435 | \n\t\t\t22.524 | \n\t\t\t22.730 | \n\t\t
\n\t\t\t\t | \n\t\t\t2.464.174 | \n\t\t\t2.667.030 | \n\t\t\t2.692.698 | \n\t\t\t2.778.978 | \n\t\t\t2.793.085 | \n\t\t
Project 1 cumulative cost data in euros.
\n\t\t\t\t | \n\t\t|||||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t1.824.282 | \n\t\t\t2.169.235 | \n\t\t\t2.255.473 | \n\t\t\t2.384.831 | \n\t\t\t2.427.950 | \n\t\t
\n\t\t\t\t | \n\t\t\t2.464.174 | \n\t\t\t2.667.030 | \n\t\t\t2.692.698 | \n\t\t\t2.778.978 | \n\t\t\t2.793.085 | \n\t\t
\n\t\t\t\t | \n\t\t\t1.538.160 | \n\t\t\t1.995.156 | \n\t\t\t2.115.866 | \n\t\t\t2.364.159 | \n\t\t\t2.427.950 | \n\t\t
\n\t\t\t\t | \n\t\t\t-926.014 | \n\t\t\t-671.874 | \n\t\t\t-576.832 | \n\t\t\t-414.819 | \n\t\t\t-365.135 | \n\t\t
\n\t\t\t\t | \n\t\t\t-286.122 | \n\t\t\t-174.079 | \n\t\t\t-139.607 | \n\t\t\t-20.672 | \n\t\t\t0 | \n\t\t
\n\t\t\t\t | \n\t\t\t0,62 | \n\t\t\t0,75 | \n\t\t\t0,79 | \n\t\t\t0,85 | \n\t\t\t0,87 | \n\t\t
\n\t\t\t\t | \n\t\t\t0,84 | \n\t\t\t0,92 | \n\t\t\t0,94 | \n\t\t\t0,99 | \n\t\t\t1,00 | \n\t\t
\n\t\t\t\t | \n\t\t\t1.300.000 | \n\t\t\t1.600.000 | \n\t\t\t1.700.000 | \n\t\t\t1.900.000 | \n\t\t\t2.000.000 | \n\t\t
Project 1 EVM and PBEV calculated parameters.
Figure 8 shows the calculated EVM parameters and figure 9 shows the calculated PBEV against the EVM for project 1.
Project 1 calculated EVM parameters AC, PV, EV.
Project 1 EVM versus PBEV.
Following is explained the calculation of the points of figure 9. Let instant time June 2008, for example, the Actual Cost, AC, is 2.667.030€, which is a project data defined in table 1. The Planned Value, PV, is the proportional part of the total budget, BAC, corresponding to the month 30, that is June 2008, over the total number of months of the project which is 36 from December 2005 to December 2008. Previously, to the initial BAC of the 2004 which was a project input data of 2.427.950€ is subtracted the costs from 2004 to 2005 of 875.661€ to consider the initial BAC updated to 2005 because in this year the project was launched again after a delay an all the project data start in 2005. The Earned Value, EV, is calculated with the rate labor hours at June 2008 over the total labor hours multiply by the BAC, resulting in 1.995.156 €. For calculating the PBEV it is considered a penalty of 25% in the EV because the engine efficiency target of 42% is not achieved and instead of that is obtained 40%.
Table 3 shows the project 2 cumulative cost data. The Budget At Completion (BAC) for project 2 was 2.616.831 euros. The costs and BAC are used as input to calculate the EVM and the PBEV parameters which are shown in table 4.
\n\t\t\t\t | \n\t\t|||||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t297.018 | \n\t\t\t298.606 | \n\t\t\t315.487 | \n\t\t\t315.742 | \n\t\t\t324.575 | \n\t\t
\n\t\t\t\t | \n\t\t\t54.467 | \n\t\t\t54.467 | \n\t\t\t54.467 | \n\t\t\t54.467 | \n\t\t\t54.467 | \n\t\t
\n\t\t\t\t | \n\t\t\t307.170 | \n\t\t\t320.940 | \n\t\t\t338.220 | \n\t\t\t346.530 | \n\t\t\t366.480 | \n\t\t
\n\t\t\t\t | \n\t\t\t111.854 | \n\t\t\t126.781 | \n\t\t\t138.642 | \n\t\t\t147.510 | \n\t\t\t159.630 | \n\t\t
\n\t\t\t\t | \n\t\t\t139.290 | \n\t\t\t139.290 | \n\t\t\t139.290 | \n\t\t\t139.290 | \n\t\t\t139.290 | \n\t\t
\n\t\t\t\t | \n\t\t\t18.770 | \n\t\t\t18.770 | \n\t\t\t18.770 | \n\t\t\t18.770 | \n\t\t\t19.370 | \n\t\t
\n\t\t\t\t | \n\t\t\t2.822 | \n\t\t\t3.000 | \n\t\t\t3.256 | \n\t\t\t3.408 | \n\t\t\t3.986 | \n\t\t
\n\t\t\t\t | \n\t\t\t931.391 | \n\t\t\t961.854 | \n\t\t\t1.008.132 | \n\t\t\t1.025.717 | \n\t\t\t1.067.798 | \n\t\t
Project 2 cumulative cost data in euros.
\n\t\t\t\t | \n\t\t|||||
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t
\n\t\t\t\t | \n\t\t\t2.030.091 | \n\t\t\t2.176.776 | \n\t\t\t2.323.461 | \n\t\t\t2.470.146 | \n\t\t\t2.616.831 | \n\t\t
\n\t\t\t\t | \n\t\t\t931.391 | \n\t\t\t961.854 | \n\t\t\t1.008.132 | \n\t\t\t1.025.717 | \n\t\t\t1.067.798 | \n\t\t
\n\t\t\t\t | \n\t\t\t307.170 | \n\t\t\t320.940 | \n\t\t\t338.220 | \n\t\t\t346.530 | \n\t\t\t366.480 | \n\t\t
\n\t\t\t\t | \n\t\t\t-624.221 | \n\t\t\t-640.914 | \n\t\t\t-669.912 | \n\t\t\t-679.187 | \n\t\t\t-701.318 | \n\t\t
\n\t\t\t\t | \n\t\t\t-1.722.921 | \n\t\t\t-1.855.836 | \n\t\t\t-1.985.241 | \n\t\t\t-2.123.616 | \n\t\t\t-2.250.351 | \n\t\t
\n\t\t\t\t | \n\t\t\t0,33 | \n\t\t\t0,33 | \n\t\t\t0,34 | \n\t\t\t0,34 | \n\t\t\t0,34 | \n\t\t
\n\t\t\t\t | \n\t\t\t0,15 | \n\t\t\t0,15 | \n\t\t\t0,15 | \n\t\t\t0,14 | \n\t\t\t0,14 | \n\t\t
\n\t\t\t\t | \n\t\t\t300.000 | \n\t\t\t300.000 | \n\t\t\t300.000 | \n\t\t\t300.000 | \n\t\t\t300.000 | \n\t\t
Project 2 EVM and PBEV calculated parameters.
Figure 10 shows the calculated EVM parameters and figure 11 shows the calculated PBEV against the EVM for project 2.
Project 2 calculated EVM parameters AC, PV, EV.
Project 2 EVM versus PBEV.
Now, it is possible to give answers to the proposed questions.
Q1: The results presented in figures 8 and 10 show that it is possible to apply the EVM to the higher level of the WBS in projects where the only information is the monthly accounting and the work progress, so the EVM parameters could be obtained and a project control with EVM is possible. For checking that the obtained values for AC, PV and EV are consistent with the EVM, it could be checked that in general when a project is finished satisfactorily the SV is zero and the SPI is 1, due to the fact that at the end of the project the earned value will match with the planned value. For the project 1, which finished satisfactorily, at the end of the project the EV fitted with the PV and therefore the SV is zero and the SPI is 1, as can be seen in table 2. By the other hand, for the project 2, which was intentionally terminated by the managing director, the EV does not reach the PV and thus, the SV never becomes zero and the SPI does not tend to 1. The EVM application in both projects is consistent with EVM rules and with the reality of the projects.
Q2: The result of PBEV presented in figures 9 and 11 shows that, once the EVM is applied, is also applicable the PBEV if they are defined penalties for when the technical targets are not fully accomplished. The manner to quantify the penalties depends on each company’s internal procedure and his technical performance measurements, as it is mentioned in [16]. For the project 1, after applying the PBEV criteria, which means a reduction in the EV value because in this project was established an engine efficiency of 42% and it reached only to 40%, the obtained PBEV is still inside an admissible range of objectives accomplishment and thus it is accepted the engine with performance 40% to be released. In the case of the project 2, the application of the PBEV is also possible but it has not much influence because of the project circumstance of have been stopped by Managing Director. Thus, this project had not time to correct the situation even the PBEV gives a more realistic status of objectives accomplishment.
Q3: As the PBEV using the EV with penalty adjust the real situation of the project integrating technical targets, cost and schedule, it captures properly the real situation in an engine development project where the accomplishment of the technical targets is a key parameter.
Q4: The PBEV gives useful information for the project control and helps to the decision making process regarding the technical targets compliance besides the cost and scheduling control. The proposed EV with penalty in the PBEV reduce the EV near the end of the project and this implies to take a decision between accepting the project finish with the obtained technical results under the objectives or the necessity of continue the project until the objectives are achieved.
The following conclusions could be extracted from the present work.
The EVM method to project control has been widely extended in the last ten years and a substantial amount of research has been generated in academic literature and industrial guidelines to evaluate the method and proposing extensions to improve it.
The research regarding the EVM could be classified in six main research lines according with this work. The research lines try to enhance the EVM adding to it concepts, such as, the product quality, the project risk analysis, the technical performance, a fuzzy determination of the EV, or analysing for example the EVM forecast accuracy, or even, there is a research line, the Earned Schedule, that proposes another point of view for the EVM in terms of time instead of costs.
One of the most complete extensions of the EVM is the PBEV, that is not only a new EVM metric to evaluate the technical performance but a complete system of guidelines for project management that integrates the technical performance measurement in all the project management procedures including the EVM.
The PBEV could be applied to industrial projects such as engine engineering projects in the energy field and it could be applied at the top level of the project WBS.
The case study number 1 shows that PBEV allows capturing the real project status including the technical performance. In this case, the PBEV reduce the EV near the end of the project and this implies to take a decision between accepting the project finish with the obtained technical results under the objectives or the necessity of continue the project until the reach the objectives.
The case study number 2 shows that PBEV could be applied to a project that finish dramatically but it does not contribute significantly to give early warnings of the health of the project if the project finished by other issue regardless the technical performance.
In a complementary way to the PBEV that considers EV with penalty when the technical target is not achieved, it could be proposed other penalties in the PBEV variables, such as, the penalty to the AC to capture the reduction in supplier’s fees when the technical targets are not met or when the project suffers an unexpected increase in the cost of any task or component. This AC with penalty could be an improvement in the project management as a tool also for risk management.
The future research in general will include probably new metrics in the EVM methodology to take into account issues like risk analysis or quality and technical performance for a more efficient project control. By the moment, these issues depend on the practitioners, to be included in the project scheduling by means of milestones which is quite subjective.
Moreover, the combination of other project management techniques with EVM is also a good practice that is under developing by some authors.
Which it is sure is that the EVM will take place as a common tool in the project management as Gantt did in the past because it is easy, quick, an efficient.
Traditional societies have long considered what it means to be male or female, masculine and feminine. Ancestors have watched the sun and the moon for clues and signs as to natures of man and woman, masculine and feminine [1]. The creation stories around the world have always included roles of masculine and feminine in forming the world as we know it and its organizing principles [2, 3, 4]. Moreover, many places around the world did not organize their society within fixed, mutable concepts of positional understanding of masculine or feminine, but in the sense of balance, and acknowledged other possibilities of existence in between being male or female [5, 6, 7, 8, 9]. Both in human and animals, there has been recognition in diversity and transformative powers in the early times of society [1, 10, 11]. These societies had their own narratives on sex development and these remained throughout time.
Western narratives in sex and development have origins that can be traced back to medical and nonmedical philosophers over the last 2000 years. In Particular, the ideas from Aristotle, Plato, and Galen were influential medical thought on sex and development [12]. The ideas of how sex developed by these medical minds are somewhat strange today but set the early beginnings of scientific and medical understanding of sex development from the seventeenth century [12, 13]. For example, Aristotle did not see men and women as identical but nor did he see them as polar opposites [12]. Through the expansion of the Roman Empire, there was a strong influence of religious ideals of sex which had held until the seventeenth century. Of interesting note, and seldom discussed of Western thought, intersex people have been used to understand the true nature of sex and what it could or should mean and understanding normal and abnormal development [14].
From the seventeenth century with pioneering new medical and scientific technologies, it was possible to understand sex diversity in its elements such as genetics and chromosomes, hormones, enzymes, anatomy such as genitals and gonads, and the many others. These have been important to understanding how sex develops. This chapter does not intend to reproduce detail of each of these in defining what they are, their variations, and involvement in development. There are many textbooks and articles explaining each of these.
The chapter focuses on the narrative of the understanding of sex and development. Science as with every area of life is explained and understood through narratives. Facts never speak for themselves, rather they are understood within schemas and worldviews through those narratives. Sex and development is a good example of one such point. Science has demonstrated much diversity is the elements considered to make up sex – chromosomal, genetic, gonadal, internal genital, external genital, pubertal, and psychological [13]. These have been understood for some time now. Sex development through the elements of sex is understood through narratives, and these narratives affect people’s lives, physically, psychologically, and socially. Biologist Joan Roughgarden asks how do two fertilized eggs that start out looking about the same end up producing two adults as different as a man or woman, drag queen, or CEO [11]. How we understand the question and how it is narrated is of interest in this chapter. What is called normal and how it affects people who are outside normal is also important.
From narratives taught at school through to academic articles and books, the idea that biology controls development of the body. It is seen as a natural, biological process that begins from the joining of the two gametes – the egg and the sperm. From this point, a linear development progression begins that leads to a human being. It is that developing body that interacts with society. The chapter identifies how the current narratives either reinforce a biological essentialism or diminish the importance of biology in the narrative through social constructionism. There are issues with narrating through a biological essentialism of sex while also using a social construction of gender. Development cannot be reduced to either.
Rather the chapter focuses on the need to consider an alternative version of develop that is not focused on development like a mechanism nor as a social construction of development. The alternative is one of sex/gender narrative of becoming. It is a means of embodiment as through embodied being becomes from pre-birth through death. It is a narrativity of becoming that recognizes both a biological and social, and cultural being interacting with the surrounding environment.
The purpose of the chapter is not to debate the physiology, but how the narratives of these in development occur. It will do so through the differentiating between sex development or sex becoming. As the chapter will illustrate, the difference in the narrative is the difference of how people react to the body and the outside world throughout their life and also how medicine and society reacts to people of sex/gender diversity.
Before continuing on the focus of sex and gender development, it is important to have a brief discussion of particular framings that have been utilized in interpreting sex development. These framings have often limited discussion and the historicity of such framings have often either been ignored or been forgotten in relation to discussion of sex development.
The two framings of focus here that influence the discussion of sex development are biological determinism and social constructionism. The influences of both of these have had political impact on the biological and social lives of people over the last many hundreds of years. In particular, these framings have had negative impact on diversity of sex and gender. It is important to break these down to understand the nuggets of truth in them, if there are any, and separate from issues to have oppressed groups of people.
Biological determinism is the basic idea is that there is an underlying true essence that discontinues between forms of the essence and has a constancy in the absence of change over time (p. 13) [15]. Biological determinism represents the claim that the present states of human societies are the specific result of biological forces and the biological “nature” of the human species [16]. Biological determinism refers to the idea that human behavior originates in and is dictated by biological entities or processes, either innate or constitutional (p. 16) [17]. The essence indicates that certain phenomena are natural, inevitable, universal, and biologically determined, and any variation is attributed to the imperfect manifestation of the essences (p. 10) [15].
Biological determinism of sex thus is the criteria that determine as two discrete true forms – male and female – with no overlap or ambiguity. The biological traits (genetic, hormonal, neuro-atomical, and so on) determine a person’s sex as male or female development through life (and holds their place in social life) with a heterosexual orientation (p. 10) [15]. Furthermore, it suggests that not only the biological traits, but also psychological and orientation reside within the individual as essence of their being (p. 13) [15].
Cultural determinism is another form believing that there are determinist attributes of being male or female that continues the Western ideals, for example, through gender. Gender is the viewpoint that women and men do differ because of socialization and that women are at least equal to and possibly superior to men [19]. It is another way to foil for biological determinism except for the biological but including virtually everything in the human social world such as capitalism, colonialism, urbanism, poverty, sexism, racism, social structure, imperialism, family structure, and an assortment of other social, economic, and political variables [18].
Social constructionism is the any social influence on individual experience [15]. Burger and Luckman propose that reality is socially constructed, and that the sociology of knowledge must analyze the process in which this occurs [20]. Social constructionism is not the trait of the individual such as taken from an essentialist position. Social constructionism sees it as a process external to the individual [15]. It suggests that the power and structures have control over the individual, and their traits are non-consequential. Moreover, while essentialists suggest universal values, social constructionists acknowledge there may be some universal traits, but there is no universal standard for such traits (p. 15) [15].
Social constructionism is often reflected through the notion of gender and development. The idea is that gender is not reliant on biological development, but the social structures in which the individual develops. It is not the gendered traits of the individual but the result social processes that are external to the individual that impact upon any traits of the individual [15]. Gender is defined by interactions between people, by language, and by the discourse of a culture [15]. Rather than conceiving of sexuality as an unchanging individual essence that we might trace over time, we can investigate its contingency upon historically specific frameworks of thought and practice (p. 91) [21].
Sex and gender development is still framed as both oppositional and disembodied. Like many concepts referred to in the nineteenth and twentieth centuries, they are seen as either/or concepts. While one framing focuses on biology or physiology drives development and behavior, the other framing disregards it in favor of the social and institutional derivation.
Basing sex/gender development in either biological determinism or social constructionism is both misleading and has negative impact on people, but especially those who do not fit within the ideals of male or female. Intersex and transgender people who have had various names over the years have been the most severely impacted through these framings and still continue till today. Both deny or ignore critical elements of how human beings become who they are.
Though Western feminists in particular long criticized the notion that the behavior and abilities of women are uniquely determined by their biology [22], they adopted the social constructionist framing established by medical professionals from psychological theory – plasticity thesis. While trying to overcome being bounded by biology, they shift the focus from biology to psychology, while maintaining the oppositional binary of being male or female.
What these narratives of biological determinism and social constructionism indicate are binary understandings and how the Western concepts of opposition hold in discourse. Science in all of its forms from biological through social science has been influenced by such discourses. Science is a process of narrating around the discover of facts and evidence. In itself, it is a set of information that is available to be women into narratives. These narratives are also influenced by ideologies and their worldview. It is time for a different discourse that recognizes truths while not essentializing individuals into a particular structure and form. It is also necessary to understand that people are not just machines open to receiving and performing or adopting social structures.
Though a person’s biology does not define a person’s life, it is still very important in the development of a person. The consideration of biology as a mechanical system or a controlling essence do a disservice to the embodiment of people and their life experience. The implicit denial of the biological events of our lives has also failed to appeal to people’s ideas of “common sense” [22]. At the same time, nonrecognition of the effects and/or interconnections of society and the environment also neglect major impacts on a person and development. Both determinism and constructionism in its forms deny connectedness and agency of the person and community.
Understanding the framing of sex/gender, it is now possible to begin to consider the narrating of the sex and gender development or becoming. Narrating is core to the human experience. Human beings are self-reflexive, narrative beings transformed its raw experiences into abstractions [26]. Becoming indicates a person with capabilities and agency, a life plan, make choices and responsible to others [27]. It is organic yet susceptible to significant environmental, social, and cultural influences, for example, it assumes that it includes meaning and is value laden [27].
Self-narration is an experience of temporal dimension that gathers events together into a coherent and meaningful structure that gives significance to the overall configuration, that is, the person [28]. Narration cannot be only understood in objective social categories, and these cannot adequately account for the lived dynamic aspects, rather resulting in reductive and reified understandings [28].
To ensure an illustrative difference, the chapter will discuss a difference between the development of sex and gender and (sex) becoming. The distinction is important as it illustrates how these narratives are written into people’s lives and what impact these narratives have.
Development since the early 1600s has been used to infer improvement, but for many individuals and collectives has resulted in quite the opposite. In terms of sex and gender, development implies a procedural sense or something being developed. It also indicates that such processes will follow linear paths from the beginning to the end. There is a determinist connotation within development and questions as to whether there is agency or autonomy possible in development. Development also suggests that that any deviations from the linear development processes are abnormalities. A clear example of such deviations is a population referred to as having disorders of sex development [29]. While there is a diversity of possibilities of the various biological parts of becoming, those not part of the ideal type are considered out of the normal, abnormal, or atypical.
In contrast, becoming is used to suggest organic nature of “becoming a person.” Becoming involves more than an individuated process. It has a multitude of influences and interconnections from the social, spiritual/cultural, and environmental embodiment of the person. Further, individual becoming always involves and is part of community sustenance and identity. Becoming is ongoing with the possibility of transformation from pre-birth through death. It is not linear nor immutable. Becoming is a narrativity of the socialized sex through the embodied physiological being with the surrounding community and context depending world.
This part of the chapter will discuss sex and gender development and the differences and similarities. It will also set out how biological determinism and social constructionism are or are not embedded in sex/gender development. It will then move to sex becoming and how that differs from sex/gender development.
To begin with, it is important to briefly describe the common narrative of sex and sex development. The common narrative also indicates particular understandings of what is abnormal, even disease, and outside of the common narrative. These variations outside of the norm have had impact on people outside of the standard ideal of the heterosexual male or female.
The narrative of sex/gender and its development must begin with the structures upon which it is based. That is, there is a norm, a standard pattern all life follows and that norm states that sex is an oppositional binary of being male or female with the male includes particular biological characteristics while the female has other characteristics. There are other general characteristics that are shared between the two – males and females.
The narrativity of sex development has an assumed foundation of an egg representing female and a sperm representing male. These are discrete and oppositional and the only possibilities. Females have XX chromosomes and particular physiology while males have XY chromosomes and particular physiology distinct from females. There are three core assumptions: it is binary (two different forms, male and female) which have distinct anatomical structures and biological functions; each form has different physical characteristics; and each form has different psychological and behavioral characteristics [30, 31]. There are two different species as male and female and not just two different reproductive systems (women have ovaries, a womb, and lactate while men are sperm producers) [32, 33, 34]. There are many texts defining these differences. Outside of these are mistakes of nature or abnormalities.
Sex development begins as process-based and linear. The very beginning of development is where the egg and the sperm meet and the egg provides an X and the sperm either an X or Y chromosome. Depending on what gene is provided from the sperm, X or Y, will determine if the newly formed zygote is a male or female. The zygote then begins the development process into either male physiology or female physiology. The presence of a Y chromosome makes the embryo develop as a male (individuals with Y will develop testes); in its absence, the default development is along the female pathway (ovaries will develop) [33]. Sex development theory assumes a master template (a master gene) as the norm that triggers a subordinate gene which cascades to downstream genes in a descending hierarchy of control [11]. As an analogy, development occurs as though a bowling ball was accurately rolled to hit a genetic kingpin at just the right spot and cause all the genetic bowling pins behind to fall down in perfect order and producing a normal baby is bowling a genetic strike [11]. This assumes there is a close linear association of “3G” sex – genetic, gonadal, and genitals – as core markers of sex [33]. The sex will then lead to the direction of other related sex characteristics. The chromosomes lead to a linear development of other anatomical structures including those often referred to as sex structures (e.g. ovaries, testes, uterus, scrotum, vagina, and clitoris) and most importantly the brain and the neural system [35].
From the time of birth, the linear development continues along the chromosomal pathway albeit at a slower pace until puberty. At puberty, sex development continues with “secondary sex characteristics” of body hair, breasts, voice, pitch, menstruation, and sexual sensations and desires [13, 35, 36]. One’s biological sex further develops into adulthood. Later in life, other factors change such as menopause in women. Up till recently, it has also been assumed that this determined sex will also determine one’s sexual relations, and hence the system of heterosexuality.
Development assumes an oppositional binary whereby from chromosomes to hormones to gonads to secondary sex characteristics there are only two choices: male (XY) or female (XX). The assumption is social sex social roles and function, expression follows on from sex development as male or female as biology established [37]. In another words, sex is understood here as a status determined by nature that unfurls into sociopolitical roles. Sex is so fundamental in the developmental program and experience is secondary to that of development in forming the male brain and male nature, or to a female brain and female nature [33].
The general sex development theory at its core is biological determinism. It infers that social development derives from the biological essence. The narrative imposed on these development systems upholds the oppression based on biological systems. It also maintains that any variation and difference is abnormal or not socially acceptable.
Prior to the 1950s, the term gender was not used, and social roles, expressions, and others relations to sex came within the umbrella of the term “sex.” The assumption was that the development of biology would extend to the developing of matching social roles and expressions and so on of society. When held strictly to such ideas, it became biological essentialism in that the person’s biology dictated the person’s position and function in society. Enforcement of biological determinism has led to sex oppression over the years, which has been often centered through patriarchy. Biological determinism of race and sex which began in the seventeenth century was recognized as having large social repercussions, especially for women and people of sex diversity [38]. Feminists have long criticized biological determinism that subordinated women to the behavior and abilities of women uniquely determined by their biology [22].
Gender as a concept and understanding arose with the rise of plasticity of human being [24]. The psychological theory posited that human beings are malleable or there is a plasticity of human beings [24]. This was the idea that humans are malleable beings and not fixed and subordinated to biological traits such as race and sex. It has its roots in the work of Konrad Lorenz concept of imprinting into dominance and adopted by Dr. John Money in establishing gender to imprint intersex people into the male–female binary [23]. The biological morphology (outer (and sometimes inner)) body was malleable and alterable [25]. The intersex and transgender persons’ bodies were alterable to fit the assigned or re-assigned gender. Dr. Robert Stoller extended the concept of gender to suggest that once a gender was assigned at birth, biology virtually superfluous except to medical professionals and produced the raw material (linear development) upon which gender developed which became known as the sex/gender split [23, 25, 39, 40, 41, 42].
Gender indicated that irrespective of the diversity of biology, a person’s development began from the assignment of gender at birth along with any necessary alteration of biology to match that assignment. A person’s gender identity derives from an inner sense of self – the psychological self – that usually matches the assignment at birth [23, 39, 43]. That sense of self develops social cues around them into the masculine and feminine person they were assigned to be. Gender development enables a concentration on the development psychological phenomena such as thoughts, behavior, and personality [23, 39]. A person has the ability to take roles that are not based on their biology in society and therefore be equal to each other – that is equality of man and woman (at least in theory). Gender development is the way a person perceives, expresses, and experiences sex identity within social relations of a social-political environment through imposed expectations (such as getting married and having children), norms, qualities, and behaviors upon an individual which vary across history societies, cultures, and classes [11, 44, 45, 46, 47, 48, 49]. Gender development is a complex process within the sociopolitical world. It is an integration of one’s “inner sense of being male or female” experienced within the sociopolitical expectations and is influenced by other’s view of themselves [50].
Gender development begins at the time of birth, though some cues are even learnt pre-birth. Late in the pre-birth process, the fetus recognizes cues of acceptability within society of what it means to be their gender [51, 52]. After birth and by the age of 5 years, a child recognizes their gender; however, the child also recognizes the what gender recognition is acceptable or needs to be concealed/suppressed within the social setting and expects them to be [53, 54]. Through the early years, the infant continues to pick up those cues around them. As the child develops, they encounter endless gender clues and hints in the real world including gender stereotypes, encouraging or discouraging words, expressions, or body language from others, and sex segregation of adult social roles [33]. These clues and hints are taken on board in the person’s gender development. Consciously or unconsciously, developing gender with its associated patterns of permitted freedoms is quickly understood including the boundaries of that gender [34].
From childhood onward, gender development is fortified through internal and external sense of their psychological self [13, 36]. Development includes socially appropriate cues of being male or female including the socially constructed roles, behavior, activities, and attributes [55]. Development is reinforced through carers, whether it is family or other members of society their own social interests in the child’s gender becoming are reinforced [56]. These considerations influence one’s inner sense of self as expectations about the characteristics men and women have, and as gender norms dictating double standards for how women and men should behave, influencing people’s interests, self-concept, performance, and beliefs about capabilities in gendered domains [33].
Moreover, as one matures, one continues to author gender as cued by relationships, society, and sociality [56]. This continues with the child as their status as sex determined, and gender authored. This becomes their sociopolitical status of life which is not escapable. It is central to and entangled within one’s social and legal life of recognition and relationality. At an early age, they pick up on cues about acceptable and non-acceptable relationships, even though they yet may not know their favored sexual relationships [53, 54]. As they turn to their teens, they begin to form relationships usually favoring culturally accepted values, such as heterosexual [53, 54]. The infant uses these ques. as a guide together with the gendered world around them in becoming their gender. These relationships primarily adhere to the sociopolitical way of life.
Gender introduced by Western feminists into the public sphere derived from and was based in the work of Dr. John Money and Dr. Robert Stoller. They accepted that through gender it was possible to socialize a person into an assigned sex stable sexed subject [23]. The focus of the theory was to normalize intersex and transgender people into the male female binary as they were creating ambiguity of the two-sex system. The sex/gender split introduced by Dr. Stoller was essential to feminist work. Removing biology as the root of the diversity enabling a capturing of these populations and normalizing them with the binary, oppositional system. Moreover, gender did not interfere with the broader institutional, patriarchal system, but only remove biology as an essence upon which it was built. This enabled women to be equal in social and psychological development as men. It was this idea that feminists adopted introducing gender into the public sphere [23, 39].
Western science has had an interesting relationship with biological diversity. As far back as the Greeks such as Aristotle and Plato, there was recognition of the diversity of being beyond male or female even though there was little acceptance of them as full human beings [12, 14]. Since the modern science period, there has been a large discovery of various diversities of sex and gender.
Sex development and diversity are not generally considered as possibility. When sex development ranged beyond the standard norm, they as considered as abnormal sex development. Though sex diversity was not fully accepted, especially in the West, under various names people we call intersex and transgender people today still existed.
Due to greater awareness of biological diversity and social unrest of norms including increasing awareness and recognition of gays and lesbians, and fear of communism, there was a need to protect the binary and diminish and erase diversity [23]. Gender was such an institution to remove sex and maintain the binary including its meaning and basis in society. Dr. John Money established gender it was to erase the possibility of intersex people and ensure they conform to being male or female to fit into society. He believed that in spite of the physiological characteristics, intersex children were malleable and could be assigned a gender – male or female – and raised accordingly [57]. Once assigned, there may be necessity to change the child’s body to match the assignment – completing what nature did not finish – and encourage child and parent bonding and development of gender [25].
Dr. Robert Stoller also worked with Money’s notion of gender in his work with transgender people. Transgender was earlier understood as a biological reality, but this was transformed by Stoller as an independent psychological phenomenon (p. 31) [23]. The development of gender identity as a psychological reality shifted sense of embodiment that transgender people once had (p. 99) [25]. Though transgender people may have desired transformative support of particular biological parts, they still would relate to the world through their body. The focus of gender changed that indicating that the relationship was through their psychological being.
Both for intersex and transgender people, they were seen as diseased and in need of a cure [11]. By fixing these groups, they could live successful lives in society. Such an implementation of social construction upon the bodies and lives of these groups was still rooted in biological determinism – the belief that there are only two human which are male or female.
Though gender was an attempt to overcome the problems of biological determinism, through using social constructionism, it is questionable to what extent it has done so. Gender and its development are underpinned by cultural determinism based in the male and female ideal (minus the control of biology). It has not freed society of the shackles of the binary understanding of the world as an immutable state and erased diversity. Though there is a use of the term gender diversity, it is in the sense of social constructionism and not including biological diversity such as intersex people exemplify nor does it provide for and enable embodiment.
The development of sex and gender indicated a linear process of development as either male or female. Any deviation was a developmental error. This has led to nonrecognition of people who are no longer recognized as a person without the help of medicine to rehabilitate them into the standardized norm as a male or female, even if it was the opposite to that assigned at birth (as with transgender people).
Narrativity of becoming is not just a different name but indicates a different way to understand a narrative of how a person becomes who they are. As mentioned earlier, it is organic interaction and interconnections of their embodied being within a social-cultural and environmental place. Embodiment moves beyond the body as a bodily form to a conception that through the body provides realms of agency, practice, custom, and so on [58]. It infers social relationality and connectedness – a sense of belonging. Embodiment indicates the agency and experience of the world through a person’s bodily form, mediated from physiology within and the cultural, social, political, and environmental world without [58]. Becoming throughout their life is inclusive of overlapping and intersecting multiplicities such as sex/gender, race, ethicality, class, (dis)ability, and so on. Becoming is a process of evolving, reinventing, or transforming nature. [62]. It is a mediation between stasis and change [28, 63] where nothing is resolved or in closure, yet often contradictory as it accommodates the emergence of new possibilities or transformations of the whole and the parts of one’s becoming [50, 62, 63, 64, 65, 66].
The very beginning of sex becoming is prenatal. As various physiological interactions begin, there are decisions made as to “pathways” of becoming of the future being. Each physiological part of a person is a the consequence of dozens of different genes and numerous pathways by which cells are assembled, differentiated, and assigned alternate functions in sex becoming [13]. Even chromosomes do not operate in isolation but require certain biochemicals called enzymes to makes the genes effective [11]. As Joan Roughgarden suggests as analogy, it is like a committee (chromosomes, hormones, enzymes, and other physiological members) that meets throughout becoming even at the early physiology stages before society and culture even have become part of the person’s becoming [11]. This analogy is important to indicate that diversity in biology and physiology is important in becoming but is not an automatic process but organic with multiple possibilities.
The processes continue from the time of birth. The only difference is that from the time of birth the social, cultural, and environmental members of the committee have more voice on the committee that they had pre-birth to continue the analogy further. Becoming continues through childhood, adolescence into adulthood. Even late into the later stages of life becoming, or even slowing of life, continues. Becoming is a recognition of the interconnectedness not only of the people around them but also the land from which they derive.
Sex becoming is the embodiment of being and belonging as male, female, both, or neither relating how they see themselves, and how they think others see them, in performing social roles, expressions, and functions through their biological body [51, 59, 60, 61]. Such a becoming enables people to connect with their spiritual and cultural ancestral beings and contribute to overall human potentiality and community sustenance and identity. Although sex becoming will always in and through social relations, the relations will not necessarily completely define us where reciprocity exists and there is respect for uniqueness of being.
Becoming is organic enables transformative possibilities. Though it recognizes biological and physiological importance, it is not as a controlling force as in biological determinism. Rather, it is in the sense of embodiment, that is through the body (whether it is in the form that one is born with or has been transformed due to medical necessity or gender-confirming need) with the social and environmental interconnectedness. What becomes clear is social constructionism does not provide the basis for embodiment and interconnectedness but leads back to a type of determinism.
The aim of this chapter was not to go through the various biological mechanisms involved in sex development. As mentioned near the beginning, there are numerous texts out there providing eloquent discussions of the various parts and their functions in the development process.
Rather, the chapter has aimed to focus on the narratives used in describing the development process. All facts are only understood when incorporated within a narrative. As noted in the chapter, all meaning is understood through narratives. Whether in early times, in the modern era, or the technological era, narratives are how humans understand the world. It is through these narratives that it is possible to indicate what something is worth and how it is valued. The narratives are also central to social organization and understanding how a person fits into the world around them and what functions they may have within society.
Sex and gender development narratives are bound within narratives that have been maintained over many years through religious and scientific dominions. The early understanding was through early form and the more direct biological determinism. Though it has largely been debunked regarding race, there is still a strong support for such ideas today regarding sex and sex development. Many of the texts do not use the words today but when read contextually still maintain such a theory.
The introduction of social constructionism, however, was aimed to curve the impact of sex determinism, or at least that is how some in the gender studies have argued. The idea of social constructionism is that biology should not and does not control destiny. Though there was oppression linked to biology as destiny, and hence the purpose for introducing social constructionism, at the same time it has led to the abandonment of embodiment. Furthermore, in particular for sex/gender development has been implemented as the same ideology as a binary, oppositional system of male and female only not based on biology determining future roles and functions of people. The result has been a cultural determinism and enforcement of a Western ideal of what is means to be male or female and the spreading of its particular narrative of sex/gender development.
The group or population that has suffered the most of both of these ideas has been those of sex/gender diversity. While under sex biological determinism has led to limited or no recognition and acceptance, under social constructionism it led to enforced transformation into assigned or reassigned genders which often also involved changing the morphology of the body to match their newly assigned genders. A greater impact for both intersex and transgender people was the loss of embodiment as the move to gender concentrated a person’s knowledge and sense of oneself was based in their psychology. Not only did it deny a relationship with the person’s body and being, but also it was an individualizing process separating people from community and connectedness. The effect of social constructionism, or even it could be argued cultural determinism, was a loss of ability to develop a diversity of being, for example as intersex or transgender, that was outside of the framing of maleness or femaleness.
Realizing development as a becoming enables a return to embodiment. It is a relation to the body (even if it be transformed from that at birth) and at the same time, a relatedness to the social and environmental world around them. Mover, becoming was organic, not linear nor immutable. It provided a means of agency yet still had bounds of social and cultural responsibility.
Understanding development as becoming recognized the complex organic being with multiple interconnected communicating with each other. From both internal and external directions, the physiological, social, psychological, and cultural multiplicities communicate and discuss at various stages of becoming of what possibilities there are and which direction to become. It is an ongoing process that continues through death where even some cultures would suggest that some of these multiplicities continue becoming in some way.
Becoming does not deny that there are external forces, yet at the same time recognizes that agency derives through the embodied being, and not simply a psychological sense of self. It is a means of acknowledging a cultural and spiritual connectedness of being along with its collective identity rather than the individualized and atomized notion of being. Becoming is a narrativity of the socialized sex through the embodied physiological being with the surrounding community and context depending world.
Understanding development through a different paradigm does not deny biological or physiological reality but does change the narrative of how life, society, and the surrounding environment connect and organize together. It provides a narrative of cohesiveness yet respect for difference and uniqueness, while individuals have duties to one another. As such, it provides a space of relationality rather the separateness and individuality that derives from sex/gender development.
The author declares no conflict of interest.
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links.
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Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5365,totalCrossrefCites:23,totalDimensionsCites:55,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3733,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"54226",title:"Localized Surface Plasmon Resonance for Optical Fiber-Sensing Applications",slug:"localized-surface-plasmon-resonance-for-optical-fiber-sensing-applications",totalDownloads:2265,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"It is well known that optical fiber sensors have attracted the attention of scientific community due to its intrinsic advantages, such as lightweight, small size, portability, remote sensing, immunity to electromagnetic interferences and the possibility of multiplexing several signals. This field has shown a dramatic growth thanks to the creation of sensitive thin films onto diverse optical fiber configurations. In this sense, a wide range of optical fiber devices have been successfully fabricated for monitoring biological, chemical, medical or physical parameters. In addition, the use of nanoparticles into the sensitive thin films has resulted in an enhancement in the response time, robustness or sensitivity in the optical devices, which is associated to the inherent properties of nanoparticles (high surface area ratio or porosity). Among all of them, the metallic nanoparticles are of great interest for sensing applications due to the presence of strong absorption bands in the visible and near-infrared regions, due to their localized surface plasmon resonances (LSPR). These optical resonances are due to the coupling of certain modes of the incident light to the collective oscillation of the conduction electrons of the metallic nanoparticles. The LSPR extinction bands are very useful for sensing applications as far as they can be affected by refractive index variations of the surrounding medium of the nanoparticles, and therefore, it is possible to create optical sensors with outstanding properties such as high sensitivity and optical self-reference. In this chapter, the attractive optical properties of metal nanostructures and their implementation into different optical fiber configuration for sensing or biosensing applications will be studied.",book:{id:"5721",slug:"nanoplasmonics-fundamentals-and-applications",title:"Nanoplasmonics",fullTitle:"Nanoplasmonics - Fundamentals and Applications"},signatures:"Pedro J. Rivero, Javier Goicoechea and Francisco J. Arregui",authors:[{id:"69816",title:"Dr.",name:"Javier",middleName:null,surname:"Goicoechea",slug:"javier-goicoechea",fullName:"Javier Goicoechea"},{id:"188796",title:"Dr.",name:"Pedro J.",middleName:null,surname:"Rivero",slug:"pedro-j.-rivero",fullName:"Pedro J. Rivero"},{id:"197277",title:"Dr.",name:"Francisco",middleName:null,surname:"Arregui",slug:"francisco-arregui",fullName:"Francisco Arregui"}]},{id:"25297",title:"Nanofabrication of Metal Oxide Patterns Using Self-Assembled Monolayers",slug:"nanofabrication-of-metal-oxide-patterns-using-self-assembled-monolayers",totalDownloads:3443,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"860",slug:"nanofabrication",title:"Nanofabrication",fullTitle:"Nanofabrication"},signatures:"Yoshitake Masuda",authors:[{id:"12385",title:"Dr.",name:"Yoshitake",middleName:null,surname:"Masuda",slug:"yoshitake-masuda",fullName:"Yoshitake Masuda"}]},{id:"77225",title:"Piezoelectricity and Its Applications",slug:"piezoelectricity-and-its-applications",totalDownloads:510,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The piezoelectric effect is extensively encountered in nature and many synthetic materials. Piezoelectric materials are capable of transforming mechanical strain and vibration energy into electrical energy. This property allows opportunities for implementing renewable and sustainable energy through power harvesting and self-sustained smart sensing in buildings. As the most common construction material, plain cement paste lacks satisfactory piezoelectricity and is not efficient at harvesting the electrical energy from the ambient vibrations of a building system. In recent years, many techniques have been proposed and applied to improve the piezoelectric capacity of cement-based composite, namely admixture incorporation and physical. The successful application of piezoelectric materials for sustainable building development not only relies on understanding the mechanism of the piezoelectric properties of various building components, but also the latest developments and implementations in the building industry. Therefore, this review systematically illustrates research efforts to develop new construction materials with high piezoelectricity and energy storage capacity. In addition, this article discusses the latest techniques for utilizing the piezoelectric materials in energy harvesters, sensors and actuators for various building systems. With advanced methods for improving the cementations piezoelectricity and applying the material piezoelectricity for different building functions, more renewable and sustainable building systems are anticipated.",book:{id:"10511",slug:"multifunctional-ferroelectric-materials",title:"Multifunctional Ferroelectric Materials",fullTitle:"Multifunctional Ferroelectric Materials"},signatures:"B. Chandra Sekhar, B. Dhanalakshmi, B. Srinivasa Rao, S. Ramesh, K. Venkata Prasad, P.S.V. Subba Rao and B. Parvatheeswara Rao",authors:[{id:"335022",title:"Dr.",name:"B. Chandra",middleName:null,surname:"Sekhar",slug:"b.-chandra-sekhar",fullName:"B. Chandra Sekhar"},{id:"422021",title:"Dr.",name:"B.",middleName:null,surname:"Dhanalakshmi",slug:"b.-dhanalakshmi",fullName:"B. Dhanalakshmi"},{id:"422022",title:"Dr.",name:"B.Srinivasa",middleName:null,surname:"Rao",slug:"b.srinivasa-rao",fullName:"B.Srinivasa Rao"},{id:"422023",title:"Dr.",name:"S.",middleName:null,surname:"Ramesh",slug:"s.-ramesh",fullName:"S. Ramesh"},{id:"422024",title:"Dr.",name:"K.Venkata",middleName:null,surname:"Prasad",slug:"k.venkata-prasad",fullName:"K.Venkata Prasad"},{id:"422025",title:"Dr.",name:"P.S.V",middleName:null,surname:"Subba Rao",slug:"p.s.v-subba-rao",fullName:"P.S.V Subba Rao"},{id:"422026",title:"Dr.",name:"B.Parvatheeswara",middleName:null,surname:"Rao",slug:"b.parvatheeswara-rao",fullName:"B.Parvatheeswara Rao"}]}],onlineFirstChaptersFilter:{topicId:"1169",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:71,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:74,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:124,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:7,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. 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He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. His research interests include biochemistry, oxidative stress, reactive species, antioxidants, lipid peroxidation, inflammation, reproductive hormones, phenolic compounds, female infertility.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. 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