\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1583",leadTitle:null,fullTitle:"Virtual Screening",title:"Virtual Screening",subtitle:null,reviewType:"peer-reviewed",abstract:"Pharmacophore modeling, QSAR analysis, CoMFA, CoMSIA, docking and molecular dynamics simulations, are currently implemented to varying degrees in virtual screening towards discovery of new bioactive hits. 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\r\n\r\n\tThe book also hopes to cover crises management and handling of communication with situational factors which cause sharp transformations on both sides economically, socially, technologically, psychologically, and so on. Theoretical and practical chapters contributing to the mentioned context are highly appreciated and welcomed.
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She also provides consultancy services for social responsibility projects.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"210632",title:"Dr.",name:"Umut",middleName:null,surname:"Ayman",slug:"umut-ayman",fullName:"Umut Ayman",profilePictureURL:"https://mts.intechopen.com/storage/users/210632/images/system/210632.jpeg",biography:"Umut Ayman completed her Bachelor’s degree in Business and her MBA in 1999 at the Eastern Mediterranean University (EMU). She completed her Communication and Media studies PhD in 2015 focusing in her thesis on consumption patterns in branded apparel products and consumers’ decision-making styles from a marketing communication perspective. Within the EMU Community Involvement Center, she provides consultancy services for social responsibility projects. 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Such substances with considerable coloring capacity are widely employed in the textile, pharmaceutical, food, cosmetics, plastics, photographic and paper industries [3,4]. The dyes can adhere to compatible surfaces by solution, by forming covalent bond or complexes with salts or metals, by physical adsorption or by mechanical retention [1,2]. Dyes are classified according to their application and chemical structure, and are composed of a group of atoms known as chromophores, responsible for the dye color. These chromophore-containing centers are based on diverse functional groups, such as azo, anthraquinone, methine, nitro, arilmethane, carbonyl and others. In addition, electrons withdrawing or donating substituents so as to generate or intensify the color of the chromophores are denominated as auxochromes. The most common auxochromes are amine, carboxyl, sulfonate and hydroxyl [5-7].
It is estimated that over 10,000 different dyes and pigments are used industrially and over 7 x 105 tons of synthetic dyes are annually produced worldwide [3,8,9]. Textile materials can be dyed using batch, continuous or semi-continuous processes. The kind of process used depends on many characteristics including type of material as such fiber, yarn, fabric, fabric construction and garment, as also the generic type of fiber, size of dye lots and quality requirements in the dyed fabric. Among these processes, the batch process is the most common method used to dye textile materials [10].
In the textile industry, up to 200,000 tons of these dyes are lost to effluents every year during the dyeing and finishing operations, due to the inefficiency of the dyeing process [9]. Unfortunately, most of these dyes escape conventional wastewater treatment processes and persist in the environment as a result of their high stability to light, temperature, water, detergents, chemicals, soap and other parameters such as bleach and perspiration [11]. In addition, anti-microbial agents resistant to biological degradation are frequently used in the manufacture of textiles, particularly for natural fibers such as cotton [11,12]. The synthetic origin and complex aromatic structure of these agents make them more recalcitrant to biodegradation [13,14]. However, environmental legislation obliges industries to eliminate color from their dye-containing effluents, before disposal into water bodies [9,12].
The textile industry consumes a substantial amount of water in its manufacturing processes used mainly in the dyeing and finishing operations of the plants. The wastewater from textile plants is classified as the most polluting of all the industrial sectors, considering the volume generated as well as the effluent composition [15-17]. In addition, the increased demand for textile products and the proportional increase in their production, and the use of synthetic dyes have together contributed to dye wastewater becoming one of the substantial sources of severe pollution problems in current times [6,9].
Textile wastewaters are characterized by extreme fluctuations in many parameters such as chemical oxygen demand (COD), biochemical oxygen demand (BOD), pH, color and salinity. The composition of the wastewater will depend on the different organic-based compounds, chemicals and dyes used in the dry and wet-processing steps [6,18]. Recalcitrant organic, colored, toxicant, surfactant and chlorinated compounds and salts are the main pollutants in textile effluents [17].
In addition, the effects caused by other pollutants in textile wastewater, and the presence of very small amounts of dyes (<1 mg/L for some dyes) in the water, which are nevertheless highly visible, seriously affects the aesthetic quality and transparency of water bodies such as lakes, rivers and others, leading to damage to the aquatic environment [19,20].
During the dyeing process it has been estimated that the losses of colorants to the environment can reach 10–50% [13,14,17,21,22]. It is noteworthy that some dyes are highly toxic and mutagenic, and also decrease light penetration and photosynthetic activity, causing oxygen deficiency and limiting downstream beneficial uses such as recreation, drinking water and irrigation [13,14,23]
With respect to the number and production volumes, azo dyes are the largest group of colorants, constituting 60-70% of all organic dyes produced in the world [2,24]. The success of azo dyes is due to the their ease and cost effectiveness for synthesis as compared to natural dyes, and also their great structural diversity, high molar extinction coefficient, and medium-to-high fastness properties in relation to light as well as to wetness [2,25]. They have a wide range of applications in the textile, pharmaceutical and cosmetic industries, and are also used in food, paper, leather and paints [26,27]. However, some azo dyes can show toxic effects, especially carcinogenic and mutagenic events [27,28].
The toxic effects of the azo dyes may result from the direct action of the agent itself or of the aryl amine derivatives generated during reductive biotransformation of the azo bond [22]. The azo dyes entering the body by ingestion can be metabolized to aromatic amines by the azoreductases of intestinal microorganisms. If the dyes are nitro, they can be metabolized by the nitroredutases produced by the same microorganisms [29]. Mammalian liver enzymes and other organizations may also catalyze the reductive cleavage of the azo bond and the nitroreduction of the nitro group. In both cases, if N-hydroxylamines are formed, these compounds are capable of causing DNA damage [29, 30].
One of the most difficult tasks confronted by the wastewater treatment plants of textile industries is the removal of the color of these compounds, mainly because dyes and pigments are designed to resist biodegradation, such that they remain in the environment for a long period of time. For example, the half-life of the hydrolyzed dye Reactive Blue 19 is about 46 years at pH 7 and 25°C [31,32].
Carneiro et al. (2010) designed and optimized an accurate and sensitive analytical method for monitoring the dyes C.I. Disperse Blue 373 (DB373), C.I. Disperse Orange 37 (DO37) and C.I. Disperse Violet 93 (DV93) in environmental samples. This investigation showed that DB373, DO37 and DV93 were present in both untreated river water and drinking water, indicating that the effluent treatment (pre-chlorination, flocculation, coagulation and flotation) generally used by drinking water treatment plants, was not entirely effective in removing these dyes. This study was confirmed by the mutagenic activity detected in these wastewaters [33].
In this context, and considering the importance of colored products in present day societies, it is of relevance to optimize the coloring process with the objective of reducing the environmental impact of the textile industry. For this purpose, liposomes could be used to carry several encapsulated dyes, and hence improve the mechanical properties of textile products, resulting in better wash fastness properties and reducing the process temperature, thus economizing energy [34]. Another way is to use ultrasonic energy, studied with the objectives of improving dye productivity and washing fastness, and reducing both energy costs and water consumption [35].
Considering the fact that the textile dyeing process is recognized as one of the most environmentally unfriendly industrial processes, it is of extreme importance to understand the critical points of the dyeing process so as to find alternative, eco-friendly methods.
The dyeing process is one of the key factors in the successful trading of textile products. In addition to the design and beautiful color, the consumer usually looks for some basic product characteristics, such as good fixation with respect to light, perspiration and washing, both initially and after prolonged use. To ensure these properties, the substances that give color to the fiber must show high affinity, uniform color, resistance to fading, and be economically feasible [36].
Modern dyeing technology consists of several steps selected according to the nature of the fiber and properties of the dyes and pigments for use in fabrics, such as chemical structure, classification, commercial availability, fixing properties compatible with the target material to be dyed, economic considerations and many others [36].
Dyeing methods have not changed much with time. Basically water is used to clean, dye and apply auxiliary chemicals to the fabrics, and also to rinse the treated fibers or fabrics [37]. The dyeing process involves three steps: preparation, dyeing and finishing, as follows:
Dyeing can be carried out as a continuous or batch process [37]. The most appropriate process to use depends on several factors, such as type of material (fiber, yarn, fabric, fabric construction, garment), generic type of fiber, size of dye batch and quality requirements for the dyed fabric, but batch processes are more commonly used to dye textile materials [10].
In continuous processing, heat and steam are applied to long rolls of fabric as they pass through a series of concentrated chemical solutions. The fabric retains the greater part of the chemicals while rinsing removes most of the preparation chemicals. Each time a fabric is passed through a solution, an amount of water equivalent to the weight of the fabric must be used [37].
In batch processing, sometimes called exhaust dyeing, since the dye is gradually transferred from the dye bath to the material being dyed over a relatively long period of time [10], the dyeing occurs in the presence of dilute chemicals in a closed equipment such as a kier, kettle, beam, jet or beck [37]. Unlike the continuous process, instead of being passed through various baths in a long series of equipment sections, in the batch process the fabric remains in a single piece of equipment, which is alternately filled with water and then drained, at each step of the process. Each time the fabric is exposed to a separate bath, it uses five to ten times its own weight in water [37].
Some batch dyeing machines only operate at temperatures up to 100ºC. However, the system can be pressurized, allowing for the use of temperatures above 100ºC. Cotton, rayon, nylon, wool and some other fibers dye well at temperatures of 100ºC or below. Polyester and some other synthetic fibers dye more easily at temperatures above 100ºC [10].
Since the degree of dye fixation depends on the nature of the fiber, it is important to consider this topic. The fibers used in the textile industry can be divided into two main groups denominated natural fibers and synthetic fibers [36,37]. Natural fibers are derived from the environment (plants or animals), such as wool, cotton, flax, silk, jute, hemp and sisal, most of which are based on cellulose and proteins. On the other hand, synthetic fibers are organic polymers, mostly derived from petroleum sources, for example, polyester, polyamide, rayon, acetate and acrylic [37,39,42]. The two most important textile fibers are cotton, the largest, and polyester [43,44].
Cotton has been used for over 7000 years, and consists of mainly cellulose, natural waxes and proteins. The large number of hydroxyl groups on the cellulose provides a great water absorption capacity [39].
Several aromatic polyesters have been synthesized and studied. Of these, polyethylene terephthalate (PET) and polybutylene terephthalate (PBT) have been produced commercially for more than 50 years. Amongst other uses, PET has been used worldwide for the production of synthetic fibers due to its good physical properties. PET is manufactured from ethylene glycol (EG) and terephthalic acid (TPA) or dimethyl terephthalate (DMT). The polymerization proceeds in two steps: esterification and condensation reactions [45]. The polymer produced after condensation is solidified by jets of cold water and cut into regular granules which frequently have a cubic form. Then, the polymer melt is spun and the yarns are solidified by a stream of cold air [39].
The dye can be fixed to the fiber by several mechanisms, generally in aqueous solution, and may involve primarily four types of interaction: ionic, Van der Waals and hydrogen interactions, and covalent bonds [5].
Ionic interactions result from interactions between oppositely charged ions present in the dyes and fibers, such as those between the positive center of the amino groups and carboxyl groups in the fiber and ionic charges on the dye molecule, and the ionic attraction between dye cations and anionic groups (-SO3- and –CO2-) present in the acrylic fiber polymer molecules. Typical examples of this type of interaction can be found in the dyeing of wool, silk and polyamide [5,36,41].
Van der Waals interactions come from a close approach between the π orbitals of the dye molecule and the fiber, so that the dye molecules are firmly "anchored" to the fiber by an affinity process without forming an actual bond. Typical examples of this type of interaction are found in the dyeing of wool and polyester with dyes with a high affinity for cellulose [36].
Hydrogen interactions are formed between hydrogen atoms covalently bonded in the dye and free electron pairs of donor atoms in the center of the fiber. This interaction can be found in the dyeing of wool, silk and synthetic fibers such as ethyl cellulose [5,36].
Covalent bonds are formed between dye molecules containing reactive groups (electrophilic groups) and nucleophilic groups on the fiber, for example, the bond between a carbon atom of the reactive dye molecule and an oxygen, nitrogen or sulfur atom of a hydroxy, amino or thiol group present in the textile fiber. This type of bond can be found in the dyeing of cotton fiber [5,36,46].
There is increasing interest in the textile industry in the development of eco-friendly textile processing, in which the use of naturally occurring materials such as phospholipids, would become important [47]. Phospholipids are natural surfactants and in the presence of water, they organize themselves so as to reduce unfavorable interactions between their hydrophobic tails and the aqueous solution; their hydrophilic head groups exposed to the aqueous phase forming vesicles. Liposomes or phospholipid vesicles are featured by clearly separate hydrophilic and hydrophobic regions [34,48].
Liposomes were first produced in England in 1961 by Alec D. Bangham, who was studying phospholipids and blood clotting. He found that when phospholipids were added to water, they immediately formed a sphere, because one end of each molecule was water soluble, while the opposite end was water insoluble [49]. From a chemical point of view, the liposome is an amphoteric compound containing both positive and negative charges [34,50].
Liposomes are defined as a structure composed of lipid vesicle bilayers which can encapsulate hydrophobic or hydrophilic compounds in the lipid bilayer or in the aqueous volume, respectively [51]. These structures are usually made up of phosphatidylcholine (PC), which has a hydrophilic part consisting of phosphate and choline groups and a hydrophobic part composed of two hydrocarbon chains of variable length [49, 52,53].
Liposomes are often distinguished according to their number of lamellae and size. Small unilamellar vesicles (SUV), large unilamellar vesicles (LUV) and large multilamellar vesicles (MLV) or multivesicular vesicles (MVV) can be differentiated [49]. The diameters of liposomes vary from a nanometer to a micrometer [34]. Multilamellar liposomes (MLV) usually range from 500 to 10,000 nm. Unilamellar liposomes can be small (SUV) or large (LUV); SUV are usually smaller than 50 nm and LUV are usually larger than 50 nm. Very large liposomes are called giant liposomes (10,000 - 10,00,000 nm). They can be either unilamellar or multilamellar. The liposomes containing encapsulated vesicles are called multi-vesicular and they range from 2,000-40,000 nm. LUVs with an asymmetric distribution of phospholipids in the bilayers are called asymmetric liposomes [54]. The thickness of the membrane (phospholipid bilayer) measures approximately 5 to 6 nm [49].
According to Sivasankar, Katyayani (2011), the preparation of liposomes is based on lipids, and those normally used are:
Natural phospholipids:
Phosphatidyl choline (PC) - Lecithin
Phosphatidyl ethanolamine (PE) - Cephalin
Phosphatidyl serine (PS)
Phosphatidyl inositol (PI)
Phosphatidyl glycerol (PG)
Synthetic phospholipids:
For saturated phospholipids:
Dipalmitoyl phosphatidyl choline (DPPC)
Distearoyl phosphatidyl choline (DSPC)
Dipalmitoyl phosphatidyl ethanolamine (DPPE)
Dipalmitoyl phosphatidyl serine (DPPS)
Dipalmitoyl phosphatidic acid (DPPA)
Dipalmitoyl phosphatidyl glycerol (DPPG)
For unsaturated phospholipids:
Dioleoyl phosphatidyl choline (DOPC)
Dioleoyl phosphatidyl glycerol (DOPG) [52].
Natural acidic lipids, such as PS, PG, PI, PA (phosphatidic acid) and cardiolipin (CL), are added when anionic liposomes are desired, and cholesterol is often included to stabilize the bilayer. These molecules are derivatives of glycerol with two alkyl groups and one amphoteric group [34].
Phosphatidylcholine is the biological lipid most widely used for producing liposomes. Liposomes based on phosphatidylcholine consist of phosphatidic acid and glycerin, with two alcohol groups esterified by fatty acids and a third group esterified by phosphoric acid, to which the amino alcohol choline is added as a polar group [34,49].
According to Barani, Montazer (2008), normally four different methods can be used for the preparation of liposomes:
Dry lipid film;
Emulsions;
Micelle-forming detergents;
Alcohol injection technology [34].
Liposomes have two distinct roles: they can provide an excellent model for biological membranes, and they are being developed as controlled delivery systems for hydrophilic and lipophilic agents [34,53,55]. They are promising candidates for adjuvant and carrier systems for drug delivery, are well-documented, and can be used for the same purpose in textile materials [33].
Encapsulation or liposome technology is applied in numerous fields, such as in pharmaceuticals, cosmetics, foods, detergents, textiles and other applications where it is important to liberate the encapsulated material slowly [34,50]. This new clean technology has already been adopted by some textile industries [52]. In recent years, liposomes have been examined as a way of delivering dyes to textiles in a cost-effective and environmentally sensitive way [56].
Conventional dyeing processes consume a great deal of energy, a significant amount of which is wasted in controlling the process parameters in order to achieve uniform results. With respect to the carrier role of liposomes, they can be used in several textile processes such as textile finishing and dyeing, with several types of dyes and fibers. They are nontoxic, biodegradable, and can encapsulate a wide range of solutes [34]. In addition, the main advantages of liposomes are a clear reduction in dyeing temperature (about 10°C as compared to conventional dyeing), improved quality of the textiles produced, with additional benefits with respect to material weight yield during subsequent spinning, improved smoothness and mechanical properties of the dyed textiles, and a clear reduction in the contamination load of the dye baths [52,57]. Low temperature gives a more natural feel and improved quality, with lower environmental impact [34].
In recent years, liposomes have been used in the textile industry as a carrier for auxiliary materials (leveling, retarding and wetting agents) in dyeing, mainly for wool dyeing, and for finishing processes [34,55]. One of the most common problems with textile auxiliaries is that they fail to form a complex in the solution bath. This problem can be solved by using liposomes with selected positive or negative charges. Liposomes can be prepared according to the type of process, solute material and fiber structure [34]. Liposomes from phospholipids have been widely used as a dye carrier in the dyeing process, and create eco-friendly textile processes. Due to their structural properties, liposomes can encapsulate hydrophilic dyes (reactive, acid and basic dyes) in the aqueous phase, and hydrophobic dyes (disperse dyes) in the phospholipid bilayers [58]. Liposomes containing a dye are generally large, irregular and unilamellar [50].
According to Barani & Montazer (2008), the application of liposomes in textile processing can be useful when the release of the solute material is important, and improves the final properties of the products. A wetting agent is required in the conventional bleaching bath of cotton fabrics, but this step can be eliminated by using liposomes. The presence of liposomes in the peroxide bleaching bath can improve the mechanical properties of fabrics and their brightness. Liposomes contain particles of oxidant present in the bleaching solution that represent an unusual reservoir, and release the bleaching agent gradually into the bleaching bath. Moreover, the encapsulation of catalysts used for the decomposition of hydrogen peroxide radicals can be another factor in retarding the rate of decomposition. In this way, liposomes act as a stabilizing agent in the bleaching bath [34].
The role of auxiliary products is very important in textile dyeing with disperse dyes [53]. These compounds show extremely low solubility in water and dispersing agents are needed to maintain a fine, stable dispersion throughout the whole dyeing process at the different temperatures. Martí et al. (2007) analyzed the usefulness of commercial textile liposomes as dispersing agents, and observed that liposomes could be considered as suitable dispersing auxiliaries for polyester dyeing at high temperatures, considering their capacity to stabilize dye dispersions and achieve a suitable dye exhaustion level, with the added value of their environmentally friendly nature [53]. Liposomes clearly improve the dispersion efficiency as compared to conventional dispersing agents [34].
Additionally, liposomes for textile use show a similar price to that of synthetic surfactants used in the dyeing of polyester with disperse dyes. However, the new technology is more environmentally friendly, and hence the reduction in the environmental problem can lead to economic advantages [53]. In addition, liposome preparations tend not to foam. This is an advantage that distinguishes liposomes from other textile auxiliaries [34].
According to Martí et al. (2010), the dyeing of wool and wool blends with the aid of liposomes has demonstrated better quality, energy saving and a reduction in the environmental impact and also the temperature could be reduced, resulting in less fiber damage. Moreover, dye bath exhaustion was shown to be over 90% at the lower temperature (80°C) used, resulting in significant savings in energy costs [55]. The impact of the dyeing process on the environment was also considerably lower, the COD being reduced by about 1000 units [53].
Therefore, liposome-based technology is an alternative, eco-friendly method, which could reduce the environmental impact, offering technical and economic advantages for the textile industry.
Ultrasound-assisted textile dyeing was first reported by Sokolov and Tumansky in 1941[59]. The basic idea of this technology is that ultrasound can enhance mass transfer by reducing the stagnant cores in the yarns. The improvements observed are generally attributed to cavitation phenomena and to other resulting physical effects such as dye dispersion (breaking up of aggregates with high relative molecular mass), degassing (expulsion of dissolved or entrapped air from the fiber capillaries), strong agitation of the liquid (reduction in thickness of the fiber-liquid boundary layer), and swelling (enhancement of dye diffusion rate inside the fiber) [59,60].
According to Vankar & Shanker (2008), ultrasound allows for process acceleration, obtaining the same or better results than existing techniques, but under less extreme conditions, i.e., lower temperatures and lower concentrations of the chemicals used. Wet textile processes assisted by ultrasound are of great interest to the textile industry for this reason [61], and Khatri et al. (2011) showed that the dyeing of polyester fiber using ultrasonic energy resulted in an increased dye uptake and enhanced dyeing rate [35].
Due to the revolution in environmental protection, the use of ultrasonic energy as a renewable source of energy in textile dyeing has been increased, due to the variety of advantages associated with it. On the other hand, there is a growing demand for natural, eco-friendly dyeing for the health sensitive application to textile garments as an alternative to harmful synthetic dyes, which poses a need for suitable effective dyeing methodologies [62].
Ultrasonic energy can clean or homogenize materials, accelerating both physical and chemical reactions, and these qualities can be used to improve textile processing methods. Environmental concern has been focused on textile processing methods for quite some time, and the use of ultrasonic energy has been widely studied in terms of improving washing fastness. The textile dyeing industry has long been struggling to cope with high energy costs, rapid technological changes and the need for a faster delivery time, and the effective management of ultrasonic energy could reduce energy costs and improve productivity [35]. Ultrasonic waves are vibrations with frequencies above 17 kHz, out of the audible range for humans, requiring a medium with elastic properties for propagation. The formation and collapse of the bubbles formed by ultrasonic waves (known as cavitation) is generally considered to be responsible for most of the physical and chemical effects of ultrasound in solid/liquid or liquid/liquid systems [63]. Cavitation is the formation of gas-filled microbubbles or cavities in a liquid, their growth, and under proper conditions, their implosive collapse [59].
It has been reported that ultrasonic energy can be applied successfully to wet textile processes, for example laundering, desizing, scouring, bleaching, mercerization of cotton fabrics, enzymatic treatment, dyeing and leather processing, together with the decoloration/mineralization of textile dyes in waste water [60].
In addition, ultrasonic irradiation shows promise, and has the potential, for use in environmental remediation, due to the formation of highly concentrated oxidizing species such as hydroxyl radicals (HO•), hydrogen radicals (H•), hydroperoxyl radicals (HO2• ) and H2O2, and localized high temperatures and pressures [59]. Therefore, the use of ultrasonic energy could indeed reduce the environmental impact caused by the textile industry.
The contamination of natural waters has become one of the biggest problems in modern society, and the economical use of this natural resource in production processes has gained special attention, since in predictions for the coming years, the amount of water required per capita is of concern. This environmental problem is related not only to its waste through misuse, but also to the release of industrial and domestic effluents [64].
Of the industries with high-polluting power, the textile dyeing industry, responsible for dyeing various types of fiber, stands out. Independent of the characteristics of the dyes chosen, the final operation of all dyeing process involves washing in baths to remove excesses of the original or hydrolyzed dyes not fixed to the fiber in the previous steps [36]. In these baths, as previously mentioned, it is estimated that approximately 10-50% of the dyes used in the dyeing process are lost, and end up in the effluent [17,21,22], contaminating the environment with about one million tons of these compounds [65]. The dyes end up in the water bodies due mainly to the use of the activated sludge treatment in the effluent treatment plants, which has been shown to be ineffective in removing the toxicity and coloring of some types of dye [33,60,66,67]. Moreover, the reduction of azo dyes by sodium hydrosulfite and the successive chlorination steps with hypochlorous acid, can form 2-benzotriazoles fenilbenzotriazol (PBTA) derivatives and highly mutagenic aromatic amines, often more mutagenic than the original dye [68]. In an aquatic environment, this dye reduction can occur in two phases: 1) The application of reducing agents to the newly-dyed fibers to remove the excess unbound dye, which could lead to "bleeding" of the fabrics during washing, and 2) The use of reducing agents in the bleaching process, in order to make the effluent colorless and conform with the legislation. This reduced colorless effluent containing dyes is sent to the municipal sewage treatment plant, where they chlorinate the effluents before releasing them into water bodies where they may generate PBTAs. Several different PBTAs are already described in the literature, and their chemical structures vary depending on the dyes that originated them [63,69].
So the release of improperly treated textile effluents into the environment can become an important source of problems for human and environmental health. The major source of dye loss corresponds to the incomplete fixation of the dyes during the textile fiber dyeing step [36].
In addition to the problem caused by the loss of dye during the dyeing process, within the context of environmental pollution, the textile industry is also focused due to the large volumes of water used by its industrial park, consequently generating large volumes of effluent [64]. It has been calculated that approximately 200 liters of water are needed for each kilogram of cotton produced [70]. These effluents are complex mixtures of many pollutants, ranging from original colors lost during the dyeing process, to associated pesticides and heavy metals [71], and when not properly treated, can cause serious contamination of the water sources [64]. So the materials that end up in the water bodies are effluents containing a high organic load and biochemical oxygen demand, low dissolved oxygen concentrations, strong color and low biodegradability. In addition to visual pollution, the pollution of water bodies with these compounds causes changes in the biological cycles of the aquatic biota, particularly affecting the photosynthesis and oxygenation processes of the water body, for example by hindering the passage of sunlight through the water [72].
Moreover, studies have shown that some classes of dye, especially azo dyes and their by-products, may be carcinogenic and / or mutagenic [27,33,67,73-77], endangering human health, since the wastewater treatment systems and water treatment plants (WTP) are ineffective in removing the color and the mutagenic properties of some dyes [78,79]. The difficulty in removing them from the environment can be attributed to the high stability of these compounds, since they are designed to resist biodegradation to meet the demands of the consumer market with respect to durability of the colors in the fibers, consequently implying that they also remain in the environment for a long time [32].
With respect to the legislation, there is no consensus amongst the different countries concerning effluent discharge, and there is no official document listing the different effluent limit values applied in different countries. Many federal countries, such as the United States of America, Canada and Australia have national environmental legislation, which, as in Europe, establishes the limits that must be complied with. Some countries, such as Thailand, have copied the American system, whereas others, such as Turkey or Morocco, have copied the European model. In some countries, for example India, Pakistan and Malaysia, the emission limits are recommended, but are not mandatory [80]. With respect to the color, in some countries such as France, Austria and Italy, there are limits for the color of the effluent, but since they use different units, a comparison is impossible. The oldest unit is the Hazen, in use since the beginning of the 20th century, but in France, the current unit is (mg L-1Pt–Co). The coloration values are determined by a comparative analysis with model solutions prepared according to defined procedures [80].
Based on all the problems cited above regarding the discharge of effluents into the environment, it is obvious there is a need to find alternative treatments that are effective in removing dyes from effluents.
These days, environmental pollution can undoubtedly be regarded as one of the main problems in developed and developing countries. This is due, not just to one, but to a number of factors, such as the misuse of natural resources, inefficient legislation and a lack of environmental awareness. Fortunately, in recent years there has been a trend for change and a series of scientific studies are being used as an important tool in the development of new treatment technologies and even in the implementation of processes and environmentally friendly actions [64,81-84].
Every industrial process is characterized by the use of inputs (raw materials, water, energy, etc.) that undergo transformation giving rise to products, byproducts and waste. The wastes produced at all stages of the various types of human activity, both in terms of composition and volume, vary according to the consumption practices and production methods. The main concerns are focused on the impact these can have on human health and the environment. Hazardous waste, produced mainly by industry, is particularly worrying, because when incorrectly managed, it becomes a serious threat to the environment and therefore to human health. Thus the study of new alternatives for the treatment of different types of industrial effluent continues to be a challenge to combat anthropogenic contamination.
Amongst that of several other industries, the textile sector waste has received considerable attention in recent years, since it can generate large volumes of effluents that, if not correctly treated before being disposed into water resources, can be a problem, as previously mentioned. Effluents from the textile industry are extremely complex, since they contain a large variety of dyes, additives and derivatives that change seasonally, increasing the challenge to find effective, feasible treatments. Currently, the processes developed and available for these industries are based on methods that were designed for other waste, and have limitations when applied to textile effluents. As a consequence, these industries produce colored wastewater with a high organic load, which can contribute enormously to the environmental pollution of surface water and treatment plants if not properly treated before disposal into the water resources [85]. The ingestion of water contaminated with textile dyes can cause serious damage to the health of humans and of other living organisms, due to the toxicity, highlighting mutagenicity of its components [86,87]. Therefore treatments that are more efficient and economical than those currently available are required.
There are several techniques for the treatment of effluents, such as incineration, biological treatment, absorption onto solid matrices, etc. However, these techniques have their drawbacks, such as the formation of dioxins and furans, caused by incomplete combustion during incineration; long periods for biological treatment to have an effect, as also the adsorptive process, that is based on the phase transfer of contaminants without actually destroying them [88,89]. The problem is further aggravated in the textile industry effluents, due to the complexity of their make-up. Thus it can be seen that processes are being used that are not entirely appropriate for the treatment of textile effluents, thereby creating a major challenge for the industry and laundries that need to adapt to current regulations for the control of the color of effluents with a high organic load.
The use of filtration membranes and/or separation [90] and biological methods [91], in addition to incineration processes involving adsorption onto solid matrices, has also being adopted by the textile industry and is receiving considerable attention. However, all these processes only involve phase transfer, generating large amounts of sludge deposited at the end of the tanks and low efficiency in color removal and reduction of the organic load. According to this scenario, many studies have been carried out with the aim of developing new technologies capable of minimizing the volume and toxicity of industrial effluents. Unfortunately, the applicability of these types of system is subject to the development of modified procedures and the establishment of effluent recycling systems, activities that imply evolutionary technologies and which are not yet universally available. Thus the study of new alternatives for the treatment of many industrial effluents currently produced is still one of the main weapons to combat the phenomenon of anthropogenic contamination.
Due to their considerable danger, several authors have attempted to find new forms of treatment to reduce the serious environmental and toxicological risks caused by various organic compounds. Amongst the many reported cases are those based on the use of specific microorganisms, and degradation using advanced oxidation processes (AOP) such as Fenton, photo-Fenton and heterogeneous photocatalysis, which are highlighted below.
The use of microorganisms cultivated specifically for the degradation of polluents to increase the yield of degradation, has been reported by some authors. For example, Flores et al. (1997) examined the behavior of 25 N-substituted aromatic compounds such as organic compounds,azo dyes and nitro, using the methanogenic bacteria acetoclastic, and found that under anaerobic conditions it was easy to mineralize various of the compounds evaluated with a good yield, especially the nitroaromatic and azo dyes [91].
Bornick et al. (2001) evaluated the use of aerobic microorganisms to degrade aromatic amines present in sediments of the river Elbe in Germany. The results obtained showed that it was possible to predict the qualitative degradation of the aromatic amines using degradation constants [92].
Using a structural design, Wang et al.(2007) isolated a bacterium capable of promoting the degradation of the compounds pentyl amine and aniline present in water oil extraction in China. Under conditions of neutral pH and complete aeration of 6 mg O2 / l at a temperature of 30 ° C, they obtained degradation yields of 82% and 78%, respectively, for pentyl amine and aniline [93].
However, in general, although the use of microorganisms in the treatment of industrial and laboratory wastes containing aromatic amines deserves attention, mainly due to the low investment and maintenance costs, the results are far from ideal, due to the low biodegradation yields, long treatment times, and the generation of sludge deposited at the bottom of the treatment ponds [94].
Of the studies carried out using a source of hydroxyl radicals with oxidizing agents, the photo Fenton system developed by Fukushima et al., 2000 to promote the degradation of aniline stands out. This method has shown promise for the mineralization of aromatic amines, obtaining a reduction of approximately 85%. However, high performance liquid chromatography (HPLC) identified a number of intermediate species formed during the degradation of the aniline, such as p-aminophenol, p-hydroquinone, maleic and fumaric acids and NH4+ [95].
Studies involving heterogeneous photocatalysis also deserve attention: for example Pramauro et al., (1995) promoted the degradation of various aniline derivatives using TiO2 particles suspended in a solution. Under optimal conditions, the method developed showed rapid mineralization of the aromatic amines examined in less than 1 hour of analysis. By-products generated during the degradation of these compounds were identified at the start of the reaction, but none were identified at the end of the reaction. The use of solar radiation was also evaluated, but was shown to be less efficient than artificial radiation [96].
Augugliaro et al.(2000), confirmed that heterogeneous photocatalysis using TiO2 as a semiconductor may be a suitable method for the complete photodegradation of aniline, 4-ethylaniline and 4-chloroaniline in an aqueous medium. The kinetic parameters for the Langmuir-Hinshelwood model were used to describe the importance of the adsorption results, which proved to be independent of the pH of the solution and of the type of substituent on the aromatic ring of the amine [97].
Canle et al. (2005) studied the behavior of the adsorption of aniline and dimethyl aniline onto three species of TiO2 (P25, anatase and rutile) and established that the greatest adsorption occurred onto TiO2 P25. The effect of pH on the degradation provided by these compounds was also evaluated, and lower mineralization percentages were observed in acidic media. This type of behavior can be attributed to the positive charges on both the aniline and the semiconductor, providing electrostatic repulsion between the two species. Thus, an alkaline medium has been recommended as the most appropriate one to promote the mineralization of aromatic amines using a TiO2 P25 type semiconductor [98].
Chu et al. (2007) observed the effects of pH variation and the addition of hydrogen peroxide on the degradation of 2-chloroaniline using TiO2 as a semiconductor, with and without the application of UV radiation. The results showed that the addition of low concentrations of H2O2 to the UV/TiO2system provided a significant increase in degradation of the aromatic amine. The addition of an excess of H2O2 promoted no increase in degradation, as expected; to the contrary, a reduction in the reaction rate was observed. The variation in pH was evaluated in both systems, and the condition leading to the highest percentages of mineralization was obtained in an alkaline medium using H2O2/UV/TiO2 [99].
Low et al. (1991) monitored the inorganic products resulting from the degradation of several organic nitrogenated, sulfured and halogenated compounds. Degradation was carried out using TiO2 as the semiconductor and artificially illuminated UV radiation. Ammonium ions were found to be present in higher concentrations than nitrate ions, which can be explained by the fact that compounds having a nitrogen element in their structure pass through a complex degradation step where the generation of ammonium ions is more favorable than the generation of nitrate ions. In turn, compounds with nitro groups in their structures, showed higher concentrations of nitrate ions. Under ideal conditions, all the elements were converted into their respective inorganic forms. Organic carbon was converted to CO2, the halogens to their corresponding halide, sulfur compounds to sulfate, the phosphate to phosphorus and nitrogen to ammonium and nitrate [100]. However, all these studies used a photocatalytic titanium suspension, requiring a subsequent step to remove the semiconductor.
With a view to these problems, a new technique that has been studied recently, with significant success, is the oxidation of organic matter via the generation of hydroxyl radicals (OH•). This kind of effluent treatment has been highlighted for its destructive character with respect to the organic matter. The advanced oxidation processes (AOP) are processes based on the generation of highly oxidizing species, the hydroxyl radical (OH•), which can oxidize the organic contaminants present in water, air or soil. These radicals have a high oxidation potential (E * = +2.72 V vs. the normal hydrogen electrode, NHE), which results in high reactivity with organic pollutants. This may initiate different types of reaction with different functional groups in organic compounds, forming unstable organic radicals which are then easily oxidized to CO2, H2O and inorganic acids, derived from this heteroatom. Many techniques have being developed using this principle as the method of treatment, and have shown potential success in organic residue mineralization processes [92,96, 101-103].
The association of the electrochemical properties with the photocatalytic properties of a semiconductor, have allowed for the development of a promising system, representing a very efficient technique as an AOP method that has received much attention in recent years, assigned as a photoelectrochemical process. The process gained notoriety for the possibility of forming hydroxyl radicals via the oxidation of water. The technique is based on the action of ultraviolet light (hυ) on a semiconductor capable of generating charges and e-/ H+, whose separation is facilitated by applying a positive potential (EAPP), greater than the potential of a flat band photocatalytic material. The generation of a potential gradient in the photoactivated semiconductor directs the electrons to an auxiliary electrode (cathode), delaying recombination between the holes (h+) generated in the valence band (VB), and making them available for oxidation processes and the generation of hydroxyl radicals of interest [104].
The results of this process were very promising because of the relatively short treatment time but with great efficiency, both in the removal of color and in the reduction of the organic load. However, the limitations of this technique are related mainly to the choice of the ideal catalyst for promoting the generation of these oxidizing species. Catalysts that promote the generation of radicals absorbing radiation in the visible spectral region are the most desirable for this type of reaction, due to the large percentage emitted in the solar spectrum (approximately 45%) [104].
Thus, the development of an ideal process that promotes color removal and a reduction in the organic load of wastewater from the textile industry with great efficiency is a major challenge in all fields of science, since the synthesis of the best catalyst to take advantage of solar radiation, thus reducing the operating costs, and at the same time solve the problems involved in the hydrodynamics of the reactors, is of importance in the development of the treatment.
The expectations for developing an effective method for the treatment of these wastes are quite promising, but require continuous optimization and knowledge of new aspects. These include better fixation of the dyes to the fibers, process with less water consumption, less hazardous dyes with respect to human health and methods capable of identifying these compounds with more efficacy and rapidity and assays to identify any potential carcinogenic and / or mutagenic properties in the dyes and their derivatives; genetic improvements to produce more efficient culture mediums and resistant biological treatments, leading to a reduction in the generation of sludge; the synthesis of materials that catalyze reactions in the visible spectral regions, leading to a more economic photoeletrochemical method, and also new engineering advances for the construction of more effective reactors, which can take advantage of all these developments in an integrated system, extending the performance of a process more appropriate for the treatment of such a complex effluent.
The search and development of new methods to promote the treatment of effluents from the textile industry with a maximum of efficiency of the process of decolorization and / or removal of these compounds present in the medium can trigger further damage human health and the environment is fundamental importance. The understanding of the composition of waste generated is extremely significant to develop these methods of treatment due to the high complexity by virtue of huge number of compounds which are added at different stages of the dyeing fabrics.
Environmental problems with used dye baths are related to the wide variety of different components added to the dye bath, often in relatively high concentrations. In the future, many of textile factories will face the requirement of reusing a significant part of all incoming freshwater because traditionally used methods are insufficient for obtaining the required water quality.
However, due to dwindling supply and increasing demand of water in the textile industries, a better alternative is to attempt to further elevate the water quality of wastewater effluent from a secondary wastewater treatment plant to a higher standard for reuse. Thus far very little attention has been paid to this aspect [105].
Therefore, the investment in the search for methodologies to more effective treatment of these effluents can be much smaller than that spent in tertiary treatment to remove these products in low level of concentrations and in the presence of much other interference. This requires action that the cost / benefit are reviewed and the development of new techniques for wastewater treatment capable of effective removal of these dyes is intensified and made economically viable [105,106].
An alternative to minimize the problems related to the treatment of textile effluents would be the development of more effective dye that can be fixed fiber with higher efficiency decreasing losses on tailings waters and reducing the amount of dye required in the dyeing process, reducing certainly improve the cost and quality of the effluent.
It was concluded that the synthetic textile dyes represent a large group of organic compounds that could have undesirable effects on the environment, and in addition, some of them can pose risks to humans. The increasing complexity and difficulty in treating textile wastes has led to a constant search for new methods that are effective and economically viable. However, up to the present moment, no efficient method capable of removing both the color and the toxic properties of the dyes released into the environment has been found.
This work was supported by the Faculty of Pharmaceutical Sciences at Ribeirão Preto - University of São Paulo, Brazil, and by FAPESP, CAPES and CNPq.
Issues related to Industry 4.0 are constantly discussed among researchers, entrepreneurs, representatives of government agencies, and public organizations. Specifically, the impacts of the Industry 4.0 paradigm in the global and national economies, individual industries, employment, and capital markets are attracting more and more attention from economists. The global industrial environment has transformed dramatically in recent years as a result of technological advances and inventions. Industry 4.0 can be compared to three industrial revolutions that happened in the previous centuries and represent the most significant disruptive shifts in manufacturing as a result of technology advancements [1].
The advent of the steam engine accelerated the First Industrial Revolution, which began in Britain in the middle of the 18th century. The Second Industrial Revolution arose in Europe and the United States in the second mid-nineteenth century. This revolution had characterized by mass manufacturing and the substitution of chemical and electrical energy for steam. Many technologies and mechanization had been developed to meet the increased demand, allowing productivity to increase [2]. The Third Industrial Revolution was sparked by the creation of the Integrated Circuit (microchip). Using electronics and information technology to accomplish increased automation in manufacturing is a significant characteristic of this revolution, which arose in many industrialized countries around the world in the later years of the twentieth century [1].
Every industrial revolution centered around boosting productivity. The first three industrial revolutions had a significant impact on industrial operations, allowing for increased productivity and efficiency by utilizing innovative technological breakthroughs, such as steam engines, electricity, and digital technology [3]. Industry 4.0, which could ultimately be referred to as the fourth industrial revolution, is a highly complex framework that has been commonly debated and discovered. It has a significant impact on the industrial sector because it introduces relevant improvements related to smart and future factories. This developing Industry 4.0 concept is an umbrella term for a new industrial paradigm that includes Cyber-Physical Systems (CPS), the Internet of Things (IoT), the Internet of Services (IoS), Robotics, Big Data, Cloud Manufacturing, and Augmented Reality, etc. [4].
The adoption of these technologies, which will bring together the digital and physical worlds through embracing a set of future industrial developments, is essential in the development of further smart industrial processes. This adoption includes devices, machines, production modules, and products that can exchange information and control each other independently, resulting in a smart manufacturing environment [5]. This new approach will allow the improvement of productivity and efficiency, carrying enormous potential effects, and it will support a set of economic and social opportunities among the companies that are adopting this new manufacturing paradigm [1].
This chapter intends to provide clear insight into the current developments within Industry 4.0 phenomenon, due to the inconsistency within the existing literature, some stress positive effects of Industry 4.0, while others, negative ones. As a result, the purpose of our research is to provide a full explanation of the Industry 4.0 paradigm, as well as to determine whether or not it is appropriate for businesses, stockholders, and countries to adopt this new approach. This chapter gives a review of Industry 4.0 and definitions in the literature, as well as introduces a brief on Industry 4.0’s main components. Additionally, this chapter’s research methodology was based on papers related to Industry 4.0, which are the most recent and cited references. As well as this study differs from past studies in several aspects, as shown in 1) It conducts a comprehensive survey of all Fourth Industrial Revolution technologies or applications, whereas earlier literature focused on one or a few technologies. 2) It performs a case study of KUKA Corporation, a pioneer company in the manufacturing technologies and applications of the Fourth Industrial Revolution.
Thus, this chapter is structured in seven sections. After this introduction about the Industry 4.0 phenomenon. Section 2 answers the question “What is the industry 4.0?”, presenting two points: an overview or background about Industry 4.0, and provides a comprehensive definition of this concept, its visions. The key Industry 4.0 technology enablers or components of Industry 4.0 characteristics are described in Section 3, which is divided into ten parts. The characteristics of Industry 4.0 state in Section 4. Section 5 provides an analysis of the impacts and influence of this new industrial paradigm: industrial sector, business models and markets, work environment, work skills, economy and sustainability, the value chains, and supply chains. While Section 6 presents the key drivers and obstacles or barriers of the Industry 4.0 concept; also, this part presents a pioneering experience in implementing the applications of the Fourth Industrial Revolution technology “KUKA corporation.” Finally, Section 7 draws the main conclusions and findings of the Industry 4.0 vision and implications.
There have been three earlier industrial revolutions that have resulted in a transformation in manufacturing patterns: mechanization via water and steam power, mass production in assembly lines, and automating through computer and information technology [6].
The first industrial revolution
The
All systems are connected, resulting in “cyber-physical production systems” and, as a result, smart factories, in which production systems, components, and people interact through a network and production is almost autonomous. When these enablers are combined, Industry 4.0 has the potential to offer some amazing improvements in manufacturing environments. Machines that can foresee faults and initiate maintenance operations on their own, for example, or self-organized logistics that adapt to unexpected changes in production are examples (Figure 1) [9].
Represents a graphic illustration of the industrial revolutions overall. Source: Constructed by the author.
It also has the ability to alter people’s working habits. Individuals can be drawn into smarter networks by Industry 4.0, which might lead to more efficient working. The manufacturing environment’s digitization provides for more flexible means of providing the appropriate information to the right person at the right time. Maintenance personnel may now receive equipment documentation and service history more quickly and at the point of use, thanks to the growing usage of digital devices inside factories and out in the field. Maintenance personnel prefer to spend their time addressing issues rather than waste time looking for technical knowledge [10].
In a summary, Industry 4.0 is a game-changer in the industrial world. Manufacturing will alter as a result of digitization, including how things are manufactured and delivered, as well as how products are maintained and enhanced. As a result, it may legitimately claim to be the start of the fourth industrial revolution. Industry 4.0 is presently taking shape and its supporting technologies, such as the Internet of Things (IoT) and Cloud Manufacturing (CM), are, nevertheless, poorly defined, and under-researched.
Industry 4.0 is better known as the fourth industrial revolution and describes a future production system’s vision. The idea of Industry 4.0 was established by a group of professionals from several professions (such as business, politics, and academia) as part of an endeavor to integrate all manufacturing industries systems to achieve sustainability. The German government initially officially approved and implemented industry 4.0 for supporting automation in manufacturing, and for boosting German competitiveness in the manufacturing industry. Essentially, as a result of Industry 4.0, operations and manufactures will become further efficient and less expensive. These are accomplished through the simple interchange of information, integrated control of industrial goods and equipment, which work synchronously and intelligently in interoperability [11]. However, several researchers have different perceptions of the meaning of industry 4.0.
Kagermann, et al. [12] stress that industry 4 utilizes the power of communications technology and innovative inventions to boost the development of the manufacturing industry. Corresponding to Kagermann et al., the primary features of the industry 4.0 idea are characterized by three aspects: (1) horizontal integration, (2) vertical integration, and (3) end-to-end digital integration of engineering. Qin, Liu, and Grosvenor [13] emphasize that industry 4.0 encourages manufacturing efficiency by collecting data, making correct decisions. By using the most advanced technologies, the procedures will be easier. The interoperability operating ability to ensure a stable manufacturing environment. This overall consciousness gives Industry 4.0 the most important aspect of artificial intelligent functions.
The Fourth Industrial Revolution, 4IR, or Industry 4.0 conceptualizes rapid change to technology, industries, and societal patterns and processes in the 21st century due to increasing interconnectivity and smart automation [14]. Schwab pointed out that Industry 4.0 is one of the most important concepts in the development of global industry and the world economy, he accentuates that, Industry 4.0 is differentiated by a few characteristics of new technologies, the improvement in technologies is bringing significant effects on industries, economies, and governments’ development plans [15]. Industry 4.0 also denotes a social, political, and economic transformation from the digital age of the late 1990s and early 2000s to an era of embedded connection marked by widespread technological use (e.g., a metaverse). That, in comparison to humans’ inherent senses and industrial ability alone, we have constructed and are entering an augmented social reality [16].
Wang et al., [17] defined the fourth industrial revolution as the modern and more sophisticated machines and tools with advanced software and networked sensors that can be used to plan, predict, adjust, and control the societal outcome and business models. Thus, Industry 4.0 is an advantage to stay competitive in any industry. Also, Industry 4.0 can be perceived as a strategy for being competitive in the future. It is focused on the optimization of value chains due to autonomously controlled and dynamic production [18]. Furthermore, industry 4.0 is possible to indicate three future-relevant themes related to it, such as: dealing with complexity, capacity for innovation, and flexibility [19].
According to the concepts above, the majority of the researchers considered Cyber-Physical Systems (CPS), Internet of Things (IoT), Industrial Internet, and other topics to be part of Industry 4.0. Numerous authors also emphasized Industry 4.0 on the cost and profitability of recently created high-tech information and intelligent services. According to previous research on Industry 4.0, the early focus was mostly on the industrial manufacturing sector, but many industries are now adopting Industry 4.0, including automotive, engineering, chemical, and electronics. As a result, Industry 4.0 is aggregating existing ideas into a different value chain that leads to an improvement in transforming entire value chains of goods life cycles while developing innovative products in manufacturing, involving the connection of systems and things that create self-organizing and dynamic control within the organization.
Industry 4.0, often referred to as the fourth industrial revolution, is the vision or scenario of a future production process characterized by new levels of controlling, organizing, and transforming the entire value chain with the life cycle of products through three types of effective integration: horizontal, vertical, and end-to-end engineering integration, resulting in increased productivity and flexibility, the industry 4.0 leads to cost optimization and reduction [11]. The Cyber-Physical Systems (CPS), Internet of Things (IoT), artificial intelligence (AI), additive manufacturing, cloud computing, and other technologies are then combined to construct dynamic, real-time optimized, and self-organizing cross-company value networks. All of these components are necessary and integral to the futuristic Industry 4.0 concept.
Industry 4.0 is a complicated technical pattern characterized primarily by connection, integration, and industrial digitalization, highlighting the possibilities for integrating all components in a value-adding system. Digital manufacturing technology, network communication technology, computer technology, and automation technology are all included in this approach. Industry 4.0 technology breakthroughs are blurring the lines between the digital and physical worlds by merging human and machine agents, materials, products, production systems, and processes [20]. Industry 4.0 enables rapid technological advancements in a variety of areas; however, the emerging fourth industrial revolution is being shaped largely by the technical integration of Cyber-Physical Systems into manufacturing processes, as well as the use of the Internet of Things and Services in industrial processes [1]. As a result, this section gives a brief overview of each significant technology driver for Industry 4.0. It also is providing information on the basic components of Industry 4.0 or key technologies enablers for Industry 4.0, which consists of 10 components.
Cyber-Physical Systems (CPS) is the combination of computational and physical processes, which are essential components of Industry 4.0 implementations. They integrate imaging and control capabilities into the relevant systems. The ability of these systems to respond to any input generated is a key feature. They provide rapid control and verification of process feedback in order to generate predicted outputs. Bergera et al. (2016) defined cyber-physical sensor systems as part of cyberspace, special types of embedded systems, based on powerful software systems, enable integration in digital networks, and generate whole new system features [21]. Generally speaking, the evolution of a CPS is characterized by three phases. Identification technologies are included in first-generation CPS. Second-generation CPS is equipped with some sensors and actuators with a limited number of functions. In the third-generation CPS, data is kept and analyzed in addition to setting up the equipment. The CPS has many sensors and actuators and is meant to be network compatible. CPSs offer various features [19].
The CPS has several sensors and actuators and is meant to operate with a network. CPSs have features including quicker information access, preventative maintenance, pre-defined decision-making, and optimization processes. Also, CPS can boost consumers awareness and consciousness. Conversely, the CPS has certain security issues, which means that further usage will definitely result in increased dangers. It was pointed out that CPS equipment might cause disruptive societal changes since intelligent assistive or autonomous environments can cause mental illnesses, which can lead to bias toward new technology adoption and usage [21]. Cyber-Physical Systems have consisted of two key components: i) A virtual environment built through computer simulation of items and actions in the actual world, and ii) a network of objects and systems interacting with each other over the internet with a designated address [4].
The term “cloud” is utilized for applications, for instance, remote services, color management, and performance benchmarking applications. It has taken remarkable attention from the IT community, and its role in other business areas will continue to grow. Machines, data management, and functionality will continue to transition away from traditional ways and toward cloud-based solutions as technology improves. The cloud enables significantly faster distribution than standalone systems, as well as quick upgrades, current performance models, and other delivery possibilities [19].
The industry has found a significant shift toward cloud solutions, which will continue to develop and represent a substantial challenge to traditional data storage methods. Cloud technology is the most basic online storage service that gives operational comfort with web-based apps that do not require any installation. Cloud computing refers to the process of storing all applications, programs, and data on a virtual server. It improves efficiency by guaranteeing those input suppliers, employees, and consumers have access to the same information at the same time [22]. Cloud Systems lower costs, simplify infrastructure, expand work areas, safeguards data, and allow for instant access to information. There are four types of the system, mainly: i) Public Cloud; ii) Private Cloud; iii) Hybrid Cloud (combination of public and private cloud); 4) Community Cloud (this refers to the co-operation of any service on the cloud with a few companies) [9].
Cloud systems are an excellent source of Big Data (which might be organized or unstructured) management solutions. Because traditional computers may not be capable of managing large amounts of data, using a cloud system to do the necessary analysis, would be much easier and more efficient. As a result, data analysis and cloud systems should be inescapable components of Industry 4.0. The integration of cloud-connected robots into everyday life, as well as their impact, is considerable [4].
Machine to machine (M2M), refers to the technology that allows direct communication between devices using any channel, wired or wireless. Machine-to-machine communication can include industrial instrumentation and personal communications [23]. M2M is also considered to be an essential component of Industry 4.0. Machine to machine (M2M) is a technology that allows devices to communicate directly with one another over any channel, wired or wireless. Machine-to-Machine Communication can include industrial instrumentation and personal networks. M2M is also considered to be an essential component of Industry 4.0. The apps are geared toward adding value to the enterprises by introducing alternative revenue streams and reducing operational costs [24].
Ackermann (2013) clearly states that M2M operations have to enable aspects with different networked organizations including i) Remote Service and Asset Information Management delivering, which provide information federation and lifecycle support. ii) Connected Vehicles, which creates relationships and interactions. iii) Smart Vending, which includes retail, supply chain, and associated sub-elements [4]. The M2M vision has raised a number of issues, including establishing smart settings, smart architecture, and a smart grid with wireless sensors, as well as developing a communication language between machines and humans, as well as between humans in different locations [23].
The Internet of Things (IoT) is an emerging concept that combines various technologies and techniques, based on the interaction between physical things and the Internet. The advancement of technology in recent decades has enabled the Internet to be expanded into a new level known as “smart objects,” which is the foundation of an IoT vision, for this, the novel pattern consists in awarding ordinary things with intelligence, permitting them not only to accumulate information and cooperate with their surroundings, but also to be interrelated with other items, communicating information, and conducted a preliminary via the Internet. The growing interest in this field, which is widely regarded as one of the primary drivers of Industry 4.0, has produced the development of a number of visions and definitions for (IoT) [1].
The Internet of Things (IoT) refers to the interconnection of physical devices, cars, buildings, and other entities that are equipped with electronics, software, sensors, actuators, and network connections to gather and share data to create a smart manufacturing environment, also known as a smart factory [25]. Additionally, the concept of “The Internet of Services (IoS)” takes a similar approach to IoT but applies it to services rather than physical assets. The Internet of Services (IoS) idea will open up new prospects for the service sector by providing a commercial and technological foundation for the construction of business networks between service providers and clients [4].
The expansion of IoT in industrial contexts and value chains will give several opportunities for users, manufacturers, and businesses, having a significant influence in a variety of industries. The Internet of Things is breaking new ground, with a slew of new applications emerging around three key pillars: i) process optimization; ii) resource optimization, and iii) the building of sophisticated autonomous systems. IoT technology will continue to evolve and spread, allowing objects to become smarter, more dependable, and autonomous, allowing for the supply of higher-value products and services [1]. On the other hand, the effectiveness of Industry 4.0 depends upon existing network infrastructure, the intelligence, and human knowledge embedded into the system [22].
“Dark factories,” “lights off factories,” and “unmanned factories” are all terms used to describe smart factories, this system is integrated with the small intervention of human beings. The individual is entering into these systems mainly in the problem-solving stages. The concept known as Lights out (dark) or unmanned factories nowadays is an automation and autonomy enhanced methodologies including equipment used in factories that actively operate the production [4, 26]. The most famous characteristic of dark factories is that they do need no human power. In unmanned factories, there is not enough time to enter the plant from the raw material to the exit from the factory. That is to say that in these factories, production is carried out entirely with robotic systems [18]. It is self-evident that smart factories will have the characteristics and procedures required by the Fourth Industrial Revolution. And these processes, which are of great importance to our future of production. Furthermore, the essential activity for generating a smart factory running under Industry 4.0 is integrating different other components together, such as big data, CPS, cloud, IoT, M2M, etc. [4]
There are many challenges that determine the formation of smart factories, such as the availability of energy and its supply, the efficiency of the labor, and the availability of the technological infrastructure necessary to shift toward smart factories. On the other hand, these factories will have a negative impact on existing employment and increase unemployment rates [7].
Every day, new goods and systems emerge as a result of technological advancements. Flying automobiles, holographic television, and hundreds of electrical devices to be implanted into the human body are all possibilities [26]. Humanoid robots will be a part of everyday life in the not-too-distant future. Recent innovations have brought about skills that empower robots to control their environment. Artificial intelligence will contribute to the development of having robot teams cooperating and collaborating in achieving certain tasks defined for a specific purpose [28].
Implementing a collaborative robot in a factory will provide several benefits for the company, including i) preventing humans from performing repetitive, non-ergonomic, and dangerous work; ii) producing high-quality products with favorable cost–benefit ratios while also increasing productivity; and iii) increasing competitiveness in comparison to countries with cheap labor [29]. When a robot is used in a productive process, the benefits of the robot utilization are combined with the effort of an operator. There is no teamwork between the man and the robot on the first level. The workplace is totally shared between the man and the robot at the final level [30].
Simulation and augmented reality (AR) is a type of enhanced reality in which live direct or indirect views of physical real-world environments are augmented with computer-generated visuals projected on top of them. Industry 4.0 applications rely heavily on this technology. This innovative technology, which is critical to the industrial revolution, was created by combining real operations and simulation industries [4]. These strategies have a lot of advantages, especially when it comes to creating products and manufacturing processes. One of the cutting-edge technologies included in the Industry 4.0 trend is augmented reality, which is particularly useful in producing smart manufacturing functions [28].
Enterprise resource planning (ERP) refers to information systems that are designed to integrate and efficiently employ all of an organization’s resources. An ERP software is a system that supports an organization in bringing together processes and data that are executed all over the processes (suppliers, production, stock, sales). ERP systems are able to provide an integrated approach to information use, to start forecasting and extracting information, which can use in various departments [4]. There is a connection between big data and Industry 4.0, Manufacturing Executive Systems (MES), cloud systems, and ERP are integrated. It is critical that all procedures in the design stage as well as the customer journey are compatible with the Industry 4.0 approach. The ERP process is also a vital component in this framework [28].
The idea of Industry 4.0 necessitates connection and collaboration criteria. End-user feedback is critical, as is providing immediate additional value to all interested parties. In order for personalization to be possible, network systems must be intelligent [22]. A telecom operator may be able to analyze network performance during fluctuations and use preventive scenarios to reduce client dissatisfaction. A well-structured ERP system can enable these characteristic features. ERP systems can help with Industry 4.0 implementations, especially as a result of the following advantages: i) Real-time data may be evaluated and allow for early detection; ii) ERP systems can provide sales and purchasing transparency; iii) ERP data may be used by mobile applications to communicate; iv) Optimum resource utilization may be achieved under varying job descriptions; v) Clients may be able to track their orders online and receive the necessary information quickly [4].
The Smart Virtual Product Development (SVPD) system is a product development decision support technology that saves, uses, and shares the experiential knowledge of previous decisional events in the form of SOEs. It was created to address the requirement for digital knowledge captured in smart manufacturing product design, production planning, and inspection planning. As a result, product quality and development time will be improved, as required by Industry 4.0 concepts [31].
The core progress from traditional manufacturing toward Industry 4.0 concluded into four key features and characteristics [32]: (1) vertical networking of smart manufacture schemes; (2) horizontal integration through a new generation of global value chain networks; (3) through-life engineering across the entire value chain; and (4) the impact of exponential technologies.
Industry 4.0′s first main characteristic is the vertical networking of smart manufacturing systems. Vertical integration in Industry 4.0 establishes a connection between the many levels of the industry, from the manufacturing floor up, via production monitoring, control, and supervision, quality management, operations, product management, processing, and so on. This interconnectedness across all corporate levels provides for a fluid, transparent data flow, allowing for data-driven strategic and tactical choices [20]. Hence, the main objective behind vertical networking is to utilize Cyber-Physical Production Systems (CPPSs), to enable industries to quickly respond to unexpected order changes resulting from demand fluctuations, equipment failure or stock shortage. Vertical networking improves an organization’s capacity to adequately adapt to changes in market requirements and benefit from new possibilities [22].
Furthermore, it makes it easier to link resources to goods and find supplies and parts at any time. Similarly, processing data, anomalies, and defects from various processing stages of the manufacturing line are automatically captured and registered, allowing for quick responses to order changes, quality variations, and even machinery breakdowns. As a consequence, waste is decreased, and resource efficiency, notably in terms of material usage, energy consumption, and human resources is improved [28].
In the Industry 4.0 concept, horizontal integration refers to the network of diverse processes, companies, and services that make up a product’s global value chain. This can be viewed at the production level as a total consolidation of all associated manufacturing processes. Vertical integration, on the other hand, refers to a high level of coordination between production and top management layers such as quality management, product management, and production control [33].
The horizontal integration in an Industry 4.0 enterprise occurs at different levels: production floor, multiple production facilities, and entire value chain. Each connected machine or production unit becomes a node with well-defined properties within the production network. These nodes continuously communicate their status to respond autonomously to dynamic production requirements cost-effectively and reduce system downtime through predictive maintenance . If an enterprise owns several production sites, the horizontal integration enables to share inventory levels and unexpected delays, and possibly redistribute work among owned facilities to respond to market demand fluctuations rapidly or increase the efficiency and speed of the production process. However, the most critical and global horizontal integration remains the integration across the entire value chain [12].
Industry 4.0 offers a highly automated and transparent collaboration across the complete value chain, using CPPSs, from the inbound assembly, packaging, storing, production, quality control, marketing, and sales, to outbound distribution, logistics, and retail services. The horizontal integration across all these activities creates a transparent value chain that is updated in real-time. Hence, this feature provides a high level of flexibility to respond more rapidly to changing market demands, shortcomings, and problems, facilitates the optimization of the production process, increases its efficiency, and reduces the generated waste [17]. Additionally, the fact that any part or product’s history is logged and can be accessed at any time ensures constant traceability, also known as “product memory” [19].
Among the characteristics of the Fourth Industrial Revolution is also the impact of the ten components of the 4th Industrial Revolution
Innovation and scientific advancements perform an essential role in businesses, sectors, and countries. However, the digital improvements and the increasing interconnectivity will bring additional challenges and upgrades to societies, since, Industry 4.0 (Ir 4.0) will significantly change the manufacturing systems in terms of design, processes, operations, and services. Industry 4.0 will lead to potential deep changes in a variety of fields outside of the industrial sector. Its influence and effect may be divided into six categories: (1) Industry sector, (2) Products and services, (3) Business models, entrepreneurship, and market competition, (4) Economies of nations, (5) Work environment, and (6) Skills development.
The industry sector will be the first to feel the effects of Industry 4.0. This new industrial paradigm will usher in a vision of manufacturing that is decentralized and digitalized, with production elements that can autonomously govern themselves, trigger operations, and adapt to changes in their surroundings. Furthermore, the developing paradigm recommends fully integrating products and processes, altering industrial vision from mass production to mass customization, resulting in increased complexity [35]. Consequently, advanced technologies and the building of smart factories will have a significant impact on production processes and operations, providing for greater operational flexibility, and more efficient utilization of resources. Industry 4.0 will have a considerable effect on the production systems, supply chains, and industrial activities. This new paradigm is changing the current industrial landscape in three ways: (1) production digitization, (2) automation, and (3) integrating the manufacturing site to a larger supply chain. Industry 4.0, in this sense, entails complete network integration and real-time data sharing [1]. Productivity growth is at the core of each industrial revolution. The 4th industrial revolution, on the other hand, will influence the entire supply chain, from product creation and manufacturing to outbound logistics, in addition to enhancing productivity [36].
ROJKO, et al. (2020) used the vector autoregression model forecast for data from the manufacturing sector in the United States over the period (2008−2018) and concluded that, the share of manufacturing output and employment has declined, and that the manufacturing sector has reached a turning point, after which robotization can increase employment and labor productivity of workers while also stimulating further growth of their education levels. They concluded that the shift to Industry 4.0 has a significant impact on the growing demand for new knowledge and skills in order to boost productivity. As a result, anticipated growths of assessed manufacturing indicators imply that the negative effects of robotization in the recent past were only transient, as the Industry 4.0 age has begun. Nonetheless, further policies are needed to enable long-term industry development [37].
This new industrial paradigm has a significant impact on products and services. Rapid changes in the economic landscape and dynamic market demands have resulted in an increased demand for the development of more complicated and intelligent products in recent years [36]. Products will become increasingly modular and configurable, allowing for mass customization to match individual consumer needs [35]. As a result, Industry 4.0 is defined by the emergence of new products and services as embedded systems that can become attentive and interactive, be managed, and tracked in real-time, optimize the entire value chain, and provide pertinent information about their status throughout their lifecycle [37].
In the previous few years, company models and markets have swiftly altered, and new inventive business models will emerge. In the context of Industry 4.0, the introduction of new disruptive technologies has altered the way products and services are sold and delivered, disrupting established enterprises, and introducing new business prospects and models [33]. As a result, value chains are becoming more responsive, as Industry 4.0 encourages integration between manufacturers and customers, allowing for closer customer connection and business model adaption to market demands. The rising digitalization of industrial production, combined with system integration and complexity, will result in the establishment of increasingly sophisticated and digital market models, boosting competitiveness by removing barriers between information and physical structures [1].
Because of technological advancements, the workplace environment is changing fast, and Industrial revolution 4.0 is redefining jobs and key competencies. The most significant transition is the human-machine connection, which includes employee contact and a set of new collaborative work approaches [18]. The number of robots and intelligent technologies is growing, the real and virtual environments are merging, implying the existing work environment is undergoing a considerable transition [13].
The rising importance of human-machine interfaces will encourage interaction between production elements as well as the necessary communication between smart machines, smart products, and employees, which will be aided by CPS’ vision of IoT and IoS. As a result, ergonomic concerns should be considered in the context of Industry 4.0, and future systems should emphasize the relevance of workers. Job profiles, as well as work management, organization, and planning will be affected by the integration of Industry 4.0 in industrial systems and the rising deployment of new technologies [12]. In this scenario, the major task is to avoid technological unemployment by reframing present jobs and taking steps to adapt the workforce to the new jobs that will be generated [28].
One of the most significant fundamental factors for a successful acceptance and implementation of the Industry 4.0 framework is skill development, which will lead to demographic and societal changes. New competencies will be required in the future work vision, and it will be vital to provide opportunities for the acquisition of these abilities through high-quality training. This new industrial paradigm will have a significant impact on the labor market and professional roles, and it will be critical to ensure that more jobs are generated than are lost [26].
Interdisciplinary thinking will be vital, and outstanding abilities in social and technological domains will be desired. The new required competency sectors must be included in schooling. As a result of Industry 4.0’s rising automation of jobs, workers must be prepared to take on new responsibilities [28]. The same can be said for engineering education, which has a lot of promise in terms of training future professionals and informing them about new technical trends and opportunities, as well as managers who need to adapt their management strategies to meet changing market demands. Furthermore, in order to address Industry 4.0, more qualified personnel will be required in technological sectors [1].
In summary, Industry 4.0 has enormous potential in many areas, and its implementation will have an impact across the entire value chain, improving production and engineering processes, improving product and service quality, optimizing customer-organization relationships, bringing new business opportunities and economic benefits, changing educational requirements, and transforming the current work environment.
An economy can be inspired by the introduction of new models and emerging technological improvements. Digitization involves the convergence between physical and virtual worlds and will have a widespread impact in every economic sector [15]. This will be the primary driving force behind innovation, which will be crucial to productivity and costs of production, which is reflected in the competitiveness (companies, sectors, and nations) [17].
Industry 4.0 also, can transform existing relationships in the manufacturing process, allowing the manufacturing sector to join the information age by allowing communication at all stages of the manufacturing process. Some academics anticipate that Industry 4.0 would lead to new economic forms in the industry, agriculture, and services [3]. The majority of businesses expect a two-year payback on their Industry 4.0 investments, which leads to a considerable rise in investment in this area is likely, it’s reflected in economic growth [37].
On the other hand, some experts believe that Industry 4.0 will result in increased inequality due to its threat of disrupting labor markets. It is argued that the continuous growth in automation, robots, and computers will take the jobs of workers in many industries with the most worrying factor being the increased danger of the disappearance of low-skill/low-pay jobs which will cause a lot of challenges for the poor, which will lead to a rise in social tensions [37]. The most concerning fact in Industry 4.0 is that it is not only the transfer of labor from one sector of the economy to another but also the availability of technology that will replace human capital, in other words, taking people’s jobs. The technological revolution will also have an impact on topics such as material or ideological changes brought about by the introduction of new gadgets or systems, all of which will have an impact on redefining humanity’s culture [3].
In general, digitization and interconnection of industrial processes, lead to potentials in all three dimensions of sustainability. However, achieving long-term benefits of sustainability is accompanied by several challenges respectively, especially in the implementation phase of Industry 4.0 [38].
Regarding the social dimension of Industry 4.0, several benefits for employees are named, such as improved human learning through intelligent assistance systems as well as human-machine interfaces that lead to increased employee satisfaction in industrial workplaces [8, 22]. However, current literature cannot provide a unified perspective on whether Industry 4.0 will cause an increase or decrease in employee numbers in the industry. In this regard, concrete numbers named differ to a large extent [3, 15]. In general, a further replacement of simple tasks is expected, whereas tasks such as monitoring, collaboration, and training will still be required [3]. Hereby, new job profiles with novel requirements for training and education are expected to emerge, mostly referring to decreasing importance of manual labor in contrast to IT skills. On the other hand, tasks that include planning and monitoring, as well as decision-making, could fall to autonomous systems, therefore, possibly replacing jobs in this area.
The fourth industrial revolution has a significant impact on supply chain interactions, which is mainly due to the exponential growth of sensible data and the widespread of digitalized processes [40]. To understand the impact of the adoption and exploitation of Industry 4.0 technologies on the value chains and supply chains (SC). Based on the review, the effect of Industry 4.0 implementation on the supply chains (SC) are identified as follows:
Despite the rapid rise of Industry 4.0, research related to the identification of potential drivers and hurdles to its implementation are scarce. To better understand the motivations and challenges to the adoption and use of Industry 4.0 technologies, a literature review was conducted. The following are the primary drivers for Industry 4.0 implementation, as determined by the review:
In this section, we introduce an overview of some applications of the Fourth Industrial Revolution. Also, we provide a case study for these applications by
The “
Similarly, using techniques such as
Another application of industry 4.0 in the
There are several applications for industry 4.0, for example, the KUKA corporation which works in the areas, for instance, smart factories, M-2-M, computing cloud, intelligent robots, e-commerce, and so on.
There are also some intimidating resisting forces, barriers, for implementing Industry 4.0 practices. These obstacles may be classified under the following business dimensions:
Additionally,
This study contributes to bridging the critical gap, by discussing the key components, characteristics, effects on many dimensions, drivers, barriers, and other implementation challenges of Industry 4.0, the fourth industrial revolution describes a future production system’s vision. Industry 4.0 is an inevitable revolution covering a wide range of innovative technologies, such as cyber-physical systems, RFID technologies, IoT, cloud computing, big data analytics, advanced robotics, smart factories, etc. The Industry 4.0 paradigm is transforming business in many industries, e.g., automotive, logistics, aerospace, and energy sectors, etc. Industry 4.0 realizes the development and integration of information and communication technologies into business processes. The capabilities or components of Industry 4.0 bring significant advantages to organizations, including customization of products, real-time data analysis, increased visibility, autonomous monitoring and control, dynamic product design and development, enhanced productivity, and competitiveness.
The key characteristic features of Industry 4.0 are collaboration and integration of schemes, both horizontal and vertical. In vertical integration, Information and Communication Technology (ICT) is integrated into various hierarchical levels of the organization, from floor-level control to production, operations, and management levels. This vertical integration networking empowers the use of components of Industry 4.0 for production to respond to demand disparity or the fluctuations in stock levels. In horizontal integration, ICT is used to exchange information between many players. Integration of these systems for a flawless collaboration, integration, and exchange of data with all the stakeholders is a complicated scenario. Implementation of Industry 4.0 apps support to reduce costs, improves productivity, efficiency, and flexibility, and enhance product customization.
Innovation and technological advancements perform an essential role in organizations, sectors, countries. However, the digital transformation improvements and the rising interconnectivity will bring new challenges to societies, since Industry 4.0 will significantly change the products and manufacturing systems regarding design, processes, operations, and services. Industry 4.0 uses several advanced tools and technologies, thus helping to redefine conventional industrial processes. Industry 4.0 has enormous potential effect in many areas, and its application will have an impact across the entire value chain, improving production and engineering processes, improving product and service quality, optimizing customer-organization relationships, bringing new business opportunities and economic benefits, changing educational requirements, and transforming the current work environment. Digitization and interconnection of industrial processes (Industry 4.0), leading to potentials in all three dimensions of sustainability.
There are several applications for industry 4.0, applied by the KUKA corporation which works in the areas, for instance, smart factories, M-2-M, computing cloud, intelligent robots, e-commerce, etc., these technologies or applications help the industry 4.0 to separate rapidly. On the other hand, there are also some barriers, for implementing Industry 4.0 practices. These obstacles may be classified into many business dimensions: financial constraints, technical competency of the focal, organizational nature, lack of management support and resistance to change, legal issues, lack of policies and support from the government.
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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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In recent years, emerging technologies such as multi-omics, high-throughput technologies, and genome editing tools could assist plant physiologists in unraveling molecular mechanisms in specific critical pathways. The global picture of physiological processes in plants needs to be investigated continually to increase our knowledge, and the resulting technologies will benefit sustainable agriculture.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11409,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:null,institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. 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