Abstract
Herbal products found abundantly in several plants are the rich source of phytochemicals with a wide range of pharmacological activities and few adverse effects. Medicinal plants contain active ingredients that assist the body in reestablishing its natural balance and healing itself. Various herbs, which are commonly used in traditional Islamic medicine, can have an impact on human body systems. Natural products are primary sources of effective drugs with novel structures and distinct mechanisms of action for the treatment of various types of complications as well as the drug discovery process. The various pharmacological properties such as antimicrobial, anticancer, antioxidant, antihypertensive, immunomodulatory, anti-inflammatory and anti-diabetic properties of several natural products are well documented in the Ayurveda and Unani system of medicine. Some of the natural products’ active ingredients have been documented, but the majority are still being researched as complementary medicine. As a result, more research is required to investigate their complementary medicine system. The present chapter provides a comprehensive update on selected traditional Islamic medicinal plants and their bioactive products mentioned in Islamic scriptures as complementary therapies to various diseases. The chapter also provides an in-depth update of pharmacological and clinical studies of natural products with special emphasis on cancer and diabetes.
Keywords
- traditional Islamic herbs
- complementary therapies
- herbal products
- pharmacological properties
1. Introduction
According to the World Health Organization, an estimated 80% of people around the world use herbal medicine. Studies show that certain herbs effectively treat several health issues, like allergies, premenstrual syndrome, chronic fatigue, cancer, diabetes and many more. India is one of the big resources of medicinal plants and natural products due to its geological diversity. In recent years, various researches have been conducted on medicinal plants and spices worldwide. Plant-derived chemicals have attracted the attention of the scientific community for their various potential positive qualities. Studies have shown that polyphenols are anti-oxidants, anti-inflammatory, cardiac and neuroprotective, as well as having anti-cancer properties [1, 2]. Some of these natural chemicals have been included in clinical trials due to their inherent biological activity in a variety of disease models [3, 4], as they exhibited promising benefits in terms of boosting the anti-proliferative response and reducing the toxicity of conventional treatments.
Islamic medicine, often known as Arabic medicine in medical history, is the science of medicine developed during the Islamic Golden Age, which lasted from the ninth to thirteenth centuries. Although the main medical tradition was Greek, it was influenced by Islamic or Prophetic Medicine, as well as folk medicine to a lesser extent. The Holy Quran has provided the knowledge for a variety of crops, including grains, seeds, and fodder, as well as their germination and growth processes in several Surah. Plants are considered a gift from God, and the Quran mentions various plant names such as Date palms, figs, olives, ginger, grapes, miswak, onion, barley, garlic, pomegranates, camphor, Christ’s thorns, bottle gourds and other significant therapeutic herbs and plants utilized as food [5, 6].
Various medicinal plants and nutraceuticals derived from different natural resources, as well as their products such as polyphenolic components, flavones, flavonoids, and antioxidants, have been found to provide significant protection against a variety of diseases [7]. Epidemiological observations show that various traditional Islamic medicinal plants have powerful disease inhibiting properties [6, 8]. Currently, developing a preventive/therapeutic drug that reduces the particular disease without harming normal cells, is the primary goal of the research performed. For instance, in the case of cancer treatment, some of the methods used by the experts to cure the condition include tumor debulking, chemotherapies, radiotherapies, targeted treatments, immunotherapies, stem cell transplants, and photodynamic therapies [9]. Around the world, researchers are trying to develop new strategies to eradicate the diseases.
The present chapter summarizes the recently reported pharmacologically and therapeutically based medicinal plants and its products mentioned in Islamic scriptures. The chapter also highlights the recent studies of medicinal plants and their natural products based on
2. Traditional Islamic medicinal plants and their products
2.1 Dates palm (Phoenix dactylifera L.) fruits
Date palm fruit has been described in traditional and alternative medicine to provide several health benefits including anticholesteremic, antidiabetic, anti-inflammatory, antioxidant, hepatoprotective and anticancer effects [12]. According to prior phytochemical studies, Date pulp fruit contains about 80% reducing sugars, including fructose, glucose, galactose, and maltose, as well as flavonoids, glycosides, polyphenols, and phytosterols [13, 14]. Phytochemicals present in dates palm fruits exhibit anti-inflammatory, cardioprotective, antioxidant, hypolipidemic and anti-apoptotic properties [15]. The main bioactive components present dates palm pulp are Carotenoids (lutein and β-carotene), phytosterols and phytoestrogens (β-sitosterol, stigmasterol, campesterol, daidzein, genistein and isofucosterol), flavonoids (apigenin, luteolin, quercetin, isoquercetrin, rutin and kaempferol) and phenolic acids (benzoic acid derivatives; p-hydroxybenzoic acid, protocatechuic acid, vanillic acid, gallic acid and syringic acid, and cinnamic acid derivatives; o-coumaric acid, p-coumaric acid, caffeic acid, and ferulic acid) (Figure 1) [10, 16].
2.1.1 Utilization of date palm fruit and its products as complementary therapies
2.1.1.1 Cancer
The ethyl acetate fraction of
2.1.1.2 Diabetes
Low glycemic index (GI) diets have been proven to be effective in the treatment of diabetes. Dates can be classed as a low GI superfood because of their high fructose content, which is sweeter and less diabetogenic than glucose [23].
2.1.1.3 Antibacterial and antiviral
The use of dates is also important for antimicrobial activities. The
2.1.1.4 Hepatoprotective and antioxidant
Date palm fruit has shown the protective effect on dimethoate induced-oxidative stress in rat liver [28]. Moreover, date palm fruits have shown anti-hyperlipidemic and hepatoprotective effects in hyperlipidemia and fatty liver male albino rats [29].
2.1.1.5 Pregnancy and delivery
The use of dates is especially important for pregnant and postnatal women. Women who consume dates before and after giving birth might strengthen their uterine muscles by consuming dates [20]. Consumption of date fruit in the last 4 weeks before labor reduced the need for initiation and augmentative labor and resulted in a better delivery outcome [30]. Due to their high fiber, iron and trace element contents, as well as their high energy and low GI, date fruits seem to be the ideal superfood for today’s health-conscious age.
2.2 Fig (Ficus carica ) fruit
One of the largest angiosperm genus, Ficus belonging to the family of Moraceae (Mulberry) are perennial plants comprising of over 800 different species including climbers, trailers, and epiphytes distributed around the tropical and sub-tropical regions worldwide [31, 32].
Bush/small tree-like appearance with single, alternating and large foliage, deep lobes with three or seven lobes; rough and hairy on the top surface; soft and hairy underneath along with smooth and gray bark. In addition to being cultivated from ancient times, they were found growing in the wild in dry and sunny places with rich and fresh soil, as well as in rocky locations. A reasonably permeable and easy draining soil is ideal for the plant’s growth; nevertheless, it can also grow in nutritionally poor soil [34]. The edible part of
Figs have acquired a considerable amount of folkloric importance and still invite the attention of researchers globally for their pharmaceutical properties to be used as complementary medicine. Ayurveda, Unani, and Siddha are the classical medicine systems of Ayurveda that have acknowledged the medicinal benefits of fig [39]. Therefore, it promises to treat and cure disorders of endocrine (diabetes), ventilatory, cardiovascular, digestive (ulcers and vomiting), urinary, reproductive (menstrual discomfort), and immune systems, as well as infectious diseases of the skin, scabies, and gonorrhea [40].
Phytochemical analysis results revealed a number of secondary metabolites being isolated from different parts of
Linolenic acid (53.1%) was found to be the most prominent fatty acid present in dried figs followed by linoleic acid (21.1%), palmitic acid (13.8%), and oleic acid (9.8%) [41]. Phenolic compounds; 3-O- and 5-O-caffeoylquinic acids, ferulic acid, quercetin-3-O-glucoside, quercetin-3-O-rutinoside, psoralen, and bergapten isolated from the fruit pulp [43]. However, numerous volatile components namely 3-methyl-butanal, 2-methyl-butanal, (E)-2-pentanal, hexanal, heptanal, octanal, and nonanal, 1-penten-3-ol, 3-methylbutanol, benzyl alcohol, (E)-2-nonenol, and phenylethyl alcohol, ketone: 6-methyl-5-hepten-2-one, esters: methyl hexanoate, methyl salicylate, and ethyl salicylate, limonene, menthol, α-pinene, β-pinene, linalool, eucalyptol, α-cubenene, copaene, β-caryophyllene, τ-muurolene, τ-cadinene, and germacrene D and β-cyclocitral were found in the
The fruits have emerged as an outstanding complementary medicine that could be used in treating leprosy, nasal hemorrhage, and deficiency disorders as well as are used in various drug preparations [45].
2.2.1 Utilization of F. carica fruits and its products as complementary therapies
2.2.1.1 Cardioprotective (hypotensive effect)
2.2.1.2 Cancer
Methanolic fruit extract of
2.2.1.3 Antioxidant and antihyperlipidemic activity
Methanolic fruit extract of
2.2.1.4 Anti-diabetic activity
As a promising nutritional intervention for acute postprandial glucose and insulin homeostasis,
2.2.1.5 Antispasmodic and antiplatelet activities
In a previous study, it has been found that the fig seems to have a spasmolytic action that might be mediated by activation of the K+-ATP channel, which supports some of its therapeutic uses in hyperactive gastrointestinal illnesses, and its antiplatelet effect [51].
2.3 Black cumin (Nigella sativa ) seed
Various therapeutic attributes of black seed and its active component thymoquinone have been shown in
The most important active compounds are thymoquinone (30–48%), thymohydroquinone, dithymoquinone, p-cymene (7–15%), carvacrol (6–12%), 4-terpineol (2–7%), t-anethol (1–4%), sesquiterpene longifolene (1–8%) α-pinene and thymol [62]. Among the various active components reported thus far, thymoquinone, which is a major component of essential oil, is the most bioactive chemical and has a variety of therapeutic properties (Figure 3).
2.3.1 Utilization of black seed and its products as complementary therapies
2.3.1.1 Anticancer activity
Thymoquinone, the active compound of the black seed helps to train T cells
2.3.1.2 Antimicrobial activity
Black cumin is one of the most inspirational medicinal plants, with potent antibacterial, antifungal, antiviral, and antiparasitic properties. Thymoquinone isolated from
2.3.1.3 Antioxidant activity
2.3.1.4 Antidiabetic activity
The administration of black cumin seed to streptozotocin-induced diabetic rats for one month resulted in a significant decrease in fasting plasma glucose, serum MDA, interleukin-6, and immunoglobulin A, G, and M, as well as a significant increase in endogenous antioxidant enzymes such as SOD, Glutathione-S-transferase, and catalase expression. Diabetes-induced elevations in tissue MDA and blood glucose were greatly reduced in rats treated with
2.3.1.5 Antihypertensive activity
According to a nonrandomized controlled trial, 57 patients who were given 2 g daily supplements of black cumin for one year showed a significant reduction in systolic, diastolic, and mean arterial BP, heart rate, TC, LDL-c, the fractions of TC/HDL-c, and LDL-c/HDL-c, while serum HDL-c was suggestively raised when compared to baseline values and the control group. It was also used to assess the blood pressure-lowering capability and possible processes of
3. Conclusions
Medicinal plants are great sources of phytochemicals, which are abundant in a variety of plants and have few negative effects. They include active chemicals that help the body recover itself and re-establish its natural equilibrium. Traditional Islamic natural products are important sources of therapeutic medications with innovative structures and modes of action for the treatment of a variety of ailments as well as the drug discovery process. The recently reported pharmacologically and therapeutically based medicinal plants and their products that are mentioned in Islamic scriptures are presented in this chapter. The current study also emphasizes recent
Acknowledgments
This work was supported by Cell and Tissue Culture Lab, Department of Biotechnology and Department of Biochemistry, Era University, Lucknow, India.
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