Properties of LDPC codes used in the WiMAX IEEE 802.16e standard.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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The throughput requirements imposed by the WiMAX standard define a maximum of 75 Mbps [IEEE P802.16e/D12, 2005], which typically demands a high number of arithmetic operations and memory accesses per second. In order to accommodate such requirements hardware-dedicated solutions were investigated and developed to deliver such computational power.
\n\t\t\tWith the number of transistors on a die approximately doubling every 18 months, we have seen in last years processors scaling up to hundreds of millions of gates. To overcome power and memory wall constraints, the industry of processors has introduced a new trend: increasing the number of cores per processor rather than using higher clock speeds. Associated to this new paradigm, new kinds of different homogeneous and heterogeneous multicore architectures have been proposed. Initially developed essentially for rendering purposes in the industry of games, recently we have seen multicores start offering new possibilities to support general purpose computing. Nowadays largely disseminated worldwide and supported by appropriate tools, they can be exploited by convenient parallel programming models delivering unmatched performances. This reality introduced the massive generalization of general purpose processing in these parallel architectures.
\n\t\t\tSo far, dedicated VLSI was the only solution capable of decoding LDPC codes at acceptable rates [Brack et al., 2006, Liu et al., 2008]. In this chapter we present a novel, programmable/flexible and scalable parallel LDPC decoding approach for the WiMAX standard based on multicore accelerators such as the Cell/B.E. architecture from Sony-Toshiba-IBM (STI) [Hofstee, 2005, International Business Machines Corporation, 2007, Falcão et al., 2008]. Moreover, we exploit parallel programming models and present parallel algorithms for this architecture [Falcão et al., 2009a]. We also report experimental results and compare them with state-of-the-art LDPC hardware decoding solutions, based on Application Specific Integrated Circuits (ASIC).
\n\t\t\tBesides the introductory and closure sections, we propose to organize this chapter around five other main sections. The second and third sections introduce, respectively, WiMAX LDPC codes and the algorithms used to perform LDPC decoding. The main characteristics of the Cell/B.E. multicore architecture are presented in section four. The fifth section describes the parallel programming models and the parallel algorithms developed to efficiently implement LDPC decoding. Finally, the experimental results section shows that the obtained throughputs compare fairly against state-of-the-art ASIC LDPC decoders.
\n\t\tThe WiMAX standard (IEEE 802.16e) works in distances typically below the 10 Km range [Falcão et al., 2008], and uses LDPC codes, whose decoders can be very demanding from a computational perspective. For this reason, they are still implemented using dedicated hardware based on ASIC solutions. LDPCs are linear (
The Forward Error Correcting (FEC) system of the WiMAX standard is based on a special class of LDPC codes [IEEE P802.16e/D12, 2005] characterized by a sparse binary block parity-check matrix H of the form:
\n\t\t\twhere H1 is sparse and adopted special periodicity constraints introduced in the pseudo random design of the matrix [IEEE P802.16e/D12, 2005; Brack et al., 2006] and H2 is a sparse lower triangular block matrix with a staircase profile. The periodic nature of these codes defines H1 based on permutation sub-matrices\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
Therefore, the LDPC codes adopted by the WiMAX standard (IEEE 802.16e) support 19 different codeword sizes with 4 distinct code rates (\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
Code | \n\t\t\t\t\t\tCodeword bits ( n ) | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\tInformation bits ( k ) | \n\t\t\t\t\t|||
(rate) | \n\t\t\t\t\t\t( rate ) | \n\t\t\t\t\t\t( rate ) | \n\t\t\t\t\t\t( rate ) | \n\t\t\t\t\t|||
\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t|||
1 | \n\t\t\t\t\t\t576 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t288 | \n\t\t\t\t\t\t384 | \n\t\t\t\t\t\t432 | \n\t\t\t\t\t\t480 | \n\t\t\t\t\t
2 | \n\t\t\t\t\t\t672 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t336 | \n\t\t\t\t\t\t448 | \n\t\t\t\t\t\t504 | \n\t\t\t\t\t\t560 | \n\t\t\t\t\t
3 | \n\t\t\t\t\t\t768 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t384 | \n\t\t\t\t\t\t512 | \n\t\t\t\t\t\t576 | \n\t\t\t\t\t\t640 | \n\t\t\t\t\t
4 | \n\t\t\t\t\t\t864 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t432 | \n\t\t\t\t\t\t576 | \n\t\t\t\t\t\t648 | \n\t\t\t\t\t\t720 | \n\t\t\t\t\t
5 | \n\t\t\t\t\t\t960 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t480 | \n\t\t\t\t\t\t640 | \n\t\t\t\t\t\t720 | \n\t\t\t\t\t\t800 | \n\t\t\t\t\t
6 | \n\t\t\t\t\t\t1056 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t528 | \n\t\t\t\t\t\t704 | \n\t\t\t\t\t\t792 | \n\t\t\t\t\t\t880 | \n\t\t\t\t\t
7 | \n\t\t\t\t\t\t1152 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t576 | \n\t\t\t\t\t\t768 | \n\t\t\t\t\t\t864 | \n\t\t\t\t\t\t960 | \n\t\t\t\t\t
8 | \n\t\t\t\t\t\t1248 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t624 | \n\t\t\t\t\t\t832 | \n\t\t\t\t\t\t936 | \n\t\t\t\t\t\t1040 | \n\t\t\t\t\t
9 | \n\t\t\t\t\t\t1344 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t672 | \n\t\t\t\t\t\t896 | \n\t\t\t\t\t\t1008 | \n\t\t\t\t\t\t1120 | \n\t\t\t\t\t
10 | \n\t\t\t\t\t\t1440 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t720 | \n\t\t\t\t\t\t960 | \n\t\t\t\t\t\t1080 | \n\t\t\t\t\t\t1200 | \n\t\t\t\t\t
11 | \n\t\t\t\t\t\t1536 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t768 | \n\t\t\t\t\t\t1024 | \n\t\t\t\t\t\t1152 | \n\t\t\t\t\t\t1280 | \n\t\t\t\t\t
12 | \n\t\t\t\t\t\t1632 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t816 | \n\t\t\t\t\t\t1088 | \n\t\t\t\t\t\t1224 | \n\t\t\t\t\t\t1360 | \n\t\t\t\t\t
13 | \n\t\t\t\t\t\t1728 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t864 | \n\t\t\t\t\t\t1152 | \n\t\t\t\t\t\t1296 | \n\t\t\t\t\t\t1440 | \n\t\t\t\t\t
14 | \n\t\t\t\t\t\t1824 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t912 | \n\t\t\t\t\t\t1216 | \n\t\t\t\t\t\t1368 | \n\t\t\t\t\t\t1520 | \n\t\t\t\t\t
15 | \n\t\t\t\t\t\t1920 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t960 | \n\t\t\t\t\t\t1280 | \n\t\t\t\t\t\t1440 | \n\t\t\t\t\t\t1600 | \n\t\t\t\t\t
16 | \n\t\t\t\t\t\t2016 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t1008 | \n\t\t\t\t\t\t1344 | \n\t\t\t\t\t\t1512 | \n\t\t\t\t\t\t1680 | \n\t\t\t\t\t
17 | \n\t\t\t\t\t\t2112 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t1056 | \n\t\t\t\t\t\t1408 | \n\t\t\t\t\t\t1584 | \n\t\t\t\t\t\t1760 | \n\t\t\t\t\t
18 | \n\t\t\t\t\t\t2208 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t1104 | \n\t\t\t\t\t\t1472 | \n\t\t\t\t\t\t1656 | \n\t\t\t\t\t\t1840 | \n\t\t\t\t\t
19 | \n\t\t\t\t\t\t2304 | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t1152 | \n\t\t\t\t\t\t1536 | \n\t\t\t\t\t\t1728 | \n\t\t\t\t\t\t1920 | \n\t\t\t\t\t
Properties of LDPC codes used in the WiMAX IEEE 802.16e standard.
To illustrate the periodic nature introduced in the design of the H matrix, the generic structure of a sample parity-check matrix used in WiMAX, with
Computationally intensive message-passing algorithms can be used for LDPC decoding, varying from the well known belief propagation, or Sum-Product algorithm (SPA) [Falcão et al., 2009a] to the more efficient but yet still intensive Min-Sum algorithm (MSA) [Falcão et al., 2008]. The intensive message passing procedure is illustrated in figure 2. We will discuss the parallelization of the SPA and MSA, and show how data dependencies can be manipulated in order to allow the implementation of parallel decoders.
\n\t\t\tPeriodicity \n\t\t\t\t\t\t
\n\t\t\t\t\t\t
The SPA is a very efficient algorithm [Lin & Costello, 2004] used for LDPC decoding and it is based on the belief propagation between adjacent nodes connected as indicated by the Tanner graph edges (figure 2). As proposed by Gallager, the SPA operates on probabilities [Gallager, 1962, Mackay & Neal, 1996, Lin & Costello, 2004]. Given a (n, k) LDPC code, we assume Binary-Phase Shift Keying (BPSK) modulation which maps a codeword c = (c1, c2,..., cn) into the sequence x = (x1, x2,..., xn), according to xi = (-1)c\n\t\t\t\t\ti. Then, x is transmitted through an additive white Gaussian noise (AWGN) channel originating the received sequence y = (y1, y2,..., yn) on the decoder side, with yi = xi + ni, where ni is a random variable with zero mean and variance σ2.
\n\t\t\t\tThe SPA is depicted from (2) to (8) [Lin & Costello, 2004]. It is mainly described by two horizontal and vertical intensive processing blocks, respectively defined by equations (3), (4) and (5), (6). The first two calculate messages moving from each CNm to BNn, considering accesses to H on a row basis. It indicates the probability of BNn being 0 or 1. Figure 2 exemplifies, for a particular 4 x 8 H matrix, BN0, BN1 and BN2 being updated by CN0, then BN3, BN4 and BN5 updated by CN1 and finally BN0, BN3, BN6 by CN2. Similarly, the vertical processing block computes messages sent from BNn to CNm, assuming accesses on a column basis. The iterative procedure is stopped if the decoded word ĉ verifies all parity-check equations of the code\n\t\t\t\t\t
A 4x8 H matrix and corresponding Tanner graph representation. The example shows messages being exchanged from CNm to BNn. A similar representation applies for messages going in the opposite direction.
{For each node pair (BNn, CNm), corresponding to \n\t\t\t\t\t
{1. Horizontal Processing (kernel 1) – Compute messages sent from CNm to BNn, that indicate the probability of BNn being 0 or 1:}
\n\t\t\t\t{where N(m)\\n represents BNs connected to CNm excluding BNn.
\n\t\t\t\t{2. Vertical Processing (kernel 2) – Compute messages sent from BNn to CNm:}
\n\t\t\t\t{where \n\t\t\t\t\t
\n\t\t\t\t\t
{3. Compute
{where \n\t\t\t\t\t
\n\t\t\t\t\t
{Perform hard decoding}\n\t\t\t\t\t
The MSA [Guilloud et al., 2003] is a simplification of the well-known SPA in the logarithmic domain. It is also based on the intensive belief propagation between nodes connected as indicated by the Tanner graph edges, but that uses only comparison and addition operations. Being one of the most efficient algorithms used for LDPC decoding [Liu et al., 2008, Seo et al., 2007], even so, the MSA still requires intensive processing.
\n\t\t\t\tLet us denote the log-likelihood ratio LLR of a random variable as
{1. Horizontal Processing (kernel 1) – Compute messages sent from CNm to BNn:}
\n\t\t\t\t{2. Vertical Processing (kernel 2) – Compute messages sent from BNn to CNm:}
\n\t\t\t\t{3. Finally, we calculate the
The required computational power and the irregular memory access patterns for LDPC decoding define hard challenges that we propose to tackle for the heterogeneous Cell/B.E. multicore [Hofstee, 2005] shown in figure 3. The Cell/B.E. processor provides a set of cores that include one main 64-bit PowerPC Processor Element (PPE) and eight Synergistic Processor Elements (SPEs) under a vectorized 128-bit wide Single Instruction Multiple Data (SIMD) oriented architecture [Sony Computer Entertainment Incorporated, 2005]. Data transfers between the main memory and each SPE’s local memory (256KByte) are performed by using efficient Direct Memory Access (DMA) mechanisms that offload the processors from the expensive task of moving data. Each SPE, by its turn, exploits quite efficiently a dual pipeline mechanism executing independently: one supports arithmetic operations; while the other performs load and store memory operations.
\n\t\t\tThe memory in the CELL/B.E. is organized as a distributed memory system. Data is loaded from the main memory into the SPE’s local storage and vice-versa, allowing each processor to exploit data locality individually. As in opposition to architectures based on shared memory models, here the programmer is free from having to deal with strategies to avoid memory access conflicts.
\n\t\tGeneric overview of the Cell/B.E. architecture.
The Single Program Multiple Data (SPMD) and the SIMD programming models are adopted to exploit data parallelism and to develop the parallel methods and algorithms for LDPC decoding on the Cell/B.E. A vectorized SIMD-based multicore approach that exploits data locality and fast data-block transfers associated to a powerful dual pipeline mechanism, allowed us to efficiently implement the concept of simultaneous multicodeword LDPC decoding on the Cell/B.E. Each SPE decodes several complete codewords and a total of 24 to 96 codewords, depending if we use 32- or 8-bit data precision, are decoded in parallel and at the same time in all the 6 SPEs available on the PlayStation 3 platform used in this work.
\n\t\t\tParallelization model for an LDPC decoder on the Cell/B.E. architecture.
The parallel LDPC decoder exploits SIMD data-parallelism by applying the same algorithm to different codewords on each SPE. As the Tanner graph is common to all codewords under decoding, these data structures can be shared allowing multicodeword decoding simultaneously in all SPEs. These features are illustrated in figure 4.
\n\t\t\tThe irregular memory access patterns common in LDPC decoding represent a challenge to the efficiency of the algorithm as illustrated in figure 5 for the example shown in figure 2. The access to different nodes in the Tanner graph is defined by the H matrix and should favor randomization in order to allow good coding gains. For that reason, the data structures developed and represented in figure 6 try to minimize that effect, by grouping contiguously in memory associated data computed in the same kernel. A global irregular access pattern is translated into several partial regular access patterns. Moreover, only non-null elements of the H matrix are stored which represents savings in terms of memory usage.
\n\t\t\tIllustration of irregular memory accesses for the example shown in
The parallelization approach proposed for developing an LDPC decoder is explained in the context of the Cell/B.E. architecture. The data structures that define the Tanner graph and the program as well are loaded into the local storage on the SPEs where the processing is performed. The LDPC decoder processes on an iterative basis. The PPE reads information yn from the input channel and produces the probabilities pn as indicated in (2). The PPE controls the main tasks, offloading the intensive processing to the SPEs, where the processing is then distributed over several threads. Each SPE runs independently of the other SPEs. After receiving the pn values associated to the corresponding codewords, each SPE performs two steps:
Segment of the SIMD vectorized data structures in memory to represent: a) \n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
The parallel LDPC decoder explores data-parallelism by applying the same algorithm to several codewords simultaneously on each SPE (as shown in figure 4). Data is represented as 32-bit precision floating-point or 8-bit integer elements, depending on the algorithm used – SPA or MSA. The proposed LDPC decoder suits scalability and for that reason it can be easily adopted by future generations of the architecture with a higher number of SPEs. In that case, it will be able of decoding more codewords simultaneously, increasing the efficiency and aggregate throughput of the decoder.
\n\t\t\t\tProcessing a complete iteration inside the SPE is performed in two phases: \n\t\t\t\t\t
\n\t\t\t\t\t
Kernel 1 performs the horizontal processing according to the Tanner graph, and the \n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
In kernel 2 data is processed in a column-major order. According to the Tanner graph, each BN updates all the CNs connected to it and holds the addresses necessary to complete the update of all \n\t\t\t\t\t
The computation is performed in the SPE for a predefined number of iterations. One of the purposes of this work is to assess the performance of the proposed solutions in terms of throughput. Pursuing this goal, we decided to develop a solution where the number of iterations is fixed to allow a fair comparison between different approaches, where the processing workload is known
Algorithm 1 PPE side of the algorithm | \n\t\t\t\t\t\t|
\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
Synchronization between the PPE and the SPEs is performed using mailboxes. This approach tries to exploit data-parallelism and data locality by performing the partitioning and mapping of the algorithm and data structures over the multiple cores, while at the same time minimizes delays caused by latency and synchronization.
\n\t\t\tThe part of the algorithm that executes on the PPE side is presented in Algorithm 1. We force the PPE to communicate with only one SPE, called MASTER SPE, which performs the control over the remaining SPEs. This is more efficient than putting the PPE controlling all the SPEs.
\n\t\t\t\tAlgorithm 2 MASTER SPE side of the algorithm | \n\t\t\t\t\t\t|
\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
The PPE receives the yn information from the channel and calculates probabilities pn, after which it sends a
Algorithm 3 SLAVE SPE side of the algorithm | \n\t\t\t\t\t\t|
\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
Finally, when all the iterations are completed, the MASTER SPE sends an
The SPEs are used in the intensive task of updating all BNs and CNs by executing kernels 1 and 2 (either for the SPA or for the MSA), in each decoding iteration. Each thread running on the SPEs accesses data in the main memory by using DMA and computes data according to the Tanner graph, as defined in the H matrix (figure 2). The MASTER SPE side of the procedure is described in Algorithm 2. The
We initialize the process and start an infinite loop, waiting for communications to arrive from the PPE (in the case of the MASTER SPE), or from the MASTER SPE (for all remaining SPEs). In the MASTER SPE, the only kind of message expected from the PPE is a
The processing starts and terminates when the number of iterations is reached and an
The intensive part of the computation in LDPC decoding on the Cell/B.E. architecture takes advantage of the processing power and SIMD instruction set available on the SPEs, which means that several codewords are decoded in parallel.
\n\t\t\tTo evaluate the performance of the proposed LDPC decoder, the Cell/B.E. was programmed using:
\n\t\t\t\t\t\t | Serial mode | \n\t\t\t\t\t\tParallel m ode | \n\t\t\t\t\t|
Platform | \n\t\t\t\t\t\tPPE | \n\t\t\t\t\t\tSTI Cell/B.E. | \n\t\t\t\t\t|
Language | \n\t\t\t\t\t\tC | \n\t\t\t\t\t\tC | \n\t\t\t\t\t|
OS | \n\t\t\t\t\t\tLinux (Fedora) kernel 2.6.16 | \n\t\t\t\t\t||
\n\t\t\t\t\t\t | PPE | \n\t\t\t\t\t\tSPE | \n\t\t\t\t\t|
Clock frequency | \n\t\t\t\t\t\t3.2GHz | \n\t\t\t\t\t\t3.2GHz | \n\t\t\t\t\t\t3.2GHz | \n\t\t\t\t\t
Memory | \n\t\t\t\t\t\t256MB | \n\t\t\t\t\t\t256MB | \n\t\t\t\t\t\t256KB | \n\t\t\t\t\t
Experimental setup.
The serial mode depicted in figure 7 uses a dual thread approach and exploits SIMD instructions. It should be noted that by performing the comparison based on the time per bit decoded, the serial solution that uses only the PPE is slower than the execution on a single SPE, because the PPE accesses slow main memory, while the SPE accesses faster local storage memory.
\n\t\t\t\tCode (n, k) | \n\t\t\t\t\t\t\tEdges | \n\t\t\t\t\t\t\tOccupancy of data structures on the local storage of a SPE (Bytes) | \n\t\t\t\t\t\t
(504, 252) | \n\t\t\t\t\t\t\t1512 | \n\t\t\t\t\t\t\t70560 | \n\t\t\t\t\t\t
(1024, 512) | \n\t\t\t\t\t\t\t3072 | \n\t\t\t\t\t\t\t143360 | \n\t\t\t\t\t\t
Size of data structures used in each SPE in parallel decoding mode.
On the parallel approach the experimental results were also obtained using SIMD instructions on the SPEs, which are responsible for executing the intensive decoding part of the algorithm. In this case the PPE orchestrates the execution on the SPEs as explained before, while inside each SPE several codewords are being simultaneously decoded in parallel. All the processing times were measured for a number of iterations ranging from 10 to 100. In literature, the average number of iterations considered for WiMAX LDPC decoders to work under realistic conditions is typically below 20 iterations [Brack et al., 2006, Seo et al., 2007, Liu et al., 2008].
\n\t\t\t\tComparing LDPC decoding times for serial and parallel modes, where codes A, B and C represent, respectively, matrices (256, 128), (504, 252) and (1024, 512).
\n\t\t\t\t\tTable 3 shows the dimensions of two regular LDPC codes with
The first parallel approach mentioned in 6.1 uses the SPA. Data elements have 32-bit floating-point precision, and 4 floating-point elements are packed and operated on a single instruction, making it possible to decode 4 codewords in parallel on each SPE. Then, with 6 SPEs available, the global architecture can decode 24 codewords in simultaneous. We assessed the results for regular codes, which typically execute faster than irregular ones. The average throughput obtained is presented in table 4, and it ranges from 69.1 to 69.5 Mbps, when decoding regular codes (504, 252) and (1024, 512) in 10 iterations. It should be noticed that the decoding time per bit and per iteration remains approximately constant. Although real-life performances demand throughputs which can be typically in the order of 40 Mbps per channel, the theoretical maximum required by the WiMAX standard can go up to approximately 75 Mbps per channel. The throughputs reported in table 4 are inferior to 70 Mbps and do not guarantee such requirements. Also, adapting the algorithm to support the necessary irregular codes used in the WiMAX would produce even worst results, because in that case accesses to memory depend on a variable number of edges per row/column. Therefore, optimizing the LDPC decoding algorithm to make it execute in a shorter period of time became mandatory. One possible solution consisted of exploiting the computationally less demanding MSA described in section 3.2.
\n\t\t\t\tCode ( n, k ) | \n\t\t\t\t\t\t\tr ate | \n\t\t\t\t\t\t\t10 iter. | \n\t\t\t\t\t\t\t25 iter. | \n\t\t\t\t\t\t\t50 iter. | \n\t\t\t\t\t\t
(504, 252) | \n\t\t\t\t\t\t\t1/2 | \n\t\t\t\t\t\t\t69.1 | \n\t\t\t\t\t\t\t28.3 | \n\t\t\t\t\t\t\t14.2 | \n\t\t\t\t\t\t
(1024, 512) | \n\t\t\t\t\t\t\t1/2 | \n\t\t\t\t\t\t\t69.5 | \n\t\t\t\t\t\t\t28.4 | \n\t\t\t\t\t\t\t14.3 | \n\t\t\t\t\t\t
Throughput (Mbps) obtained in the parallel mode for the SPA.
To increase the efficiency of the LDPC decoder we implemented the MSA on the Cell/B.E. It requires less computation, based essentially in addition and comparison operations [Falcão et al., 2009b]. Additionally, we also adopted the Forward-and-Backward simplification of the algorithm [Mackay, 1999] that avoids redundant computation and eliminates repeated accesses to memory. In the MSA data elements have 8-bit integer precision, which allows packing 16 data elements per 128-bit memory access. This increases the arithmetic intensity of the algorithm, here defined as the number of arithmetic operations per memory access, which favors the global performance of the LDPC decoder. The instruction set of the Cell/B.E. architecture supports intrinsic instructions to deal efficiently with these parallel 128-bit data types. Moreover, because there are 6 SPEs available, the algorithm now supports the simultaneous decoding of 96 codewords in parallel. However, the set of 8-bit integer intrinsic parallel instructions of the Cell/B.E. is more limited than those of the 32-bit floating-point family of instructions. This explains that the speedup obtained when changing from the SPA to the MSA is lower than we would expect. Table 5 shows the throughputs obtained for some example codes used in the WiMAX IEEE 802.16e standard. For 10 iterations, in some cases they approach quite well while in others they even surpass the 75 Mbps required by the standard to work in (theoretical) worst case conditions.
\n\t\t\t\tCode ( n, k ) | \n\t\t\t\t\t\t\tr ate | \n\t\t\t\t\t\t\t10 iter. | \n\t\t\t\t\t\t\t25 iter. | \n\t\t\t\t\t\t\t50 iter. | \n\t\t\t\t\t\t
(576, 288) | \n\t\t\t\t\t\t\t1/2 | \n\t\t\t\t\t\t\t79.8 | \n\t\t\t\t\t\t\t32.7 | \n\t\t\t\t\t\t\t16.5 | \n\t\t\t\t\t\t
(576, 432) | \n\t\t\t\t\t\t\t3/4 | \n\t\t\t\t\t\t\t7 3 . 1 | \n\t\t\t\t\t\t\t29. 9 | \n\t\t\t\t\t\t\t15.1 | \n\t\t\t\t\t\t
(576, 480) | \n\t\t\t\t\t\t\t5/6 | \n\t\t\t\t\t\t\t7 9 . 3 | \n\t\t\t\t\t\t\t3 2 . 5 | \n\t\t\t\t\t\t\t16.4 | \n\t\t\t\t\t\t
(672, 448) | \n\t\t\t\t\t\t\t2/3 | \n\t\t\t\t\t\t\t74.8 | \n\t\t\t\t\t\t\t30.6 | \n\t\t\t\t\t\t\t15.4 | \n\t\t\t\t\t\t
(672, 504) | \n\t\t\t\t\t\t\t3/4 | \n\t\t\t\t\t\t\t72.6 | \n\t\t\t\t\t\t\t29.7 | \n\t\t\t\t\t\t\t15.0 | \n\t\t\t\t\t\t
(672, 560) | \n\t\t\t\t\t\t\t5/6 | \n\t\t\t\t\t\t\t78.5 | \n\t\t\t\t\t\t\t32.2 | \n\t\t\t\t\t\t\t16.2 | \n\t\t\t\t\t\t
(960, 480 ) | \n\t\t\t\t\t\t\t1/2 | \n\t\t\t\t\t\t\t79.6 | \n\t\t\t\t\t\t\t32.6 | \n\t\t\t\t\t\t\t16.4 | \n\t\t\t\t\t\t
(960, 640 ) | \n\t\t\t\t\t\t\t2/3 | \n\t\t\t\t\t\t\t74.7 | \n\t\t\t\t\t\t\t30.6 | \n\t\t\t\t\t\t\t15.4 | \n\t\t\t\t\t\t
(960, 720 ) | \n\t\t\t\t\t\t\t3/4 | \n\t\t\t\t\t\t\t72.6 | \n\t\t\t\t\t\t\t29.7 | \n\t\t\t\t\t\t\t15.0 | \n\t\t\t\t\t\t
(960, 800 ) | \n\t\t\t\t\t\t\t5/6 | \n\t\t\t\t\t\t\t78.4 | \n\t\t\t\t\t\t\t32.1 | \n\t\t\t\t\t\t\t16.2 | \n\t\t\t\t\t\t
( 1152 , 576 ) | \n\t\t\t\t\t\t\t1/2 | \n\t\t\t\t\t\t\t79.6 | \n\t\t\t\t\t\t\t32.6 | \n\t\t\t\t\t\t\t16.4 | \n\t\t\t\t\t\t
( 1152 , 768 ) | \n\t\t\t\t\t\t\t2/3 | \n\t\t\t\t\t\t\t74.6 | \n\t\t\t\t\t\t\t30.5 | \n\t\t\t\t\t\t\t15.4 | \n\t\t\t\t\t\t
( 1152 , 864 ) | \n\t\t\t\t\t\t\t3/4 | \n\t\t\t\t\t\t\t72.6 | \n\t\t\t\t\t\t\t29.7 | \n\t\t\t\t\t\t\t15.0 | \n\t\t\t\t\t\t
( 1152 , 960 ) | \n\t\t\t\t\t\t\t5/6 | \n\t\t\t\t\t\t\t78.4 | \n\t\t\t\t\t\t\t32.1 | \n\t\t\t\t\t\t\t16.2 | \n\t\t\t\t\t\t
(1248, 624) | \n\t\t\t\t\t\t\t1/2 | \n\t\t\t\t\t\t\t79.6 | \n\t\t\t\t\t\t\t32. 6 | \n\t\t\t\t\t\t\t16.4 | \n\t\t\t\t\t\t
(1248, 832) | \n\t\t\t\t\t\t\t2/3 | \n\t\t\t\t\t\t\t78.5 | \n\t\t\t\t\t\t\t32.2 | \n\t\t\t\t\t\t\t16.2 | \n\t\t\t\t\t\t
(1248, 936) | \n\t\t\t\t\t\t\t3/4 | \n\t\t\t\t\t\t\t72. 7 | \n\t\t\t\t\t\t\t29. 7 | \n\t\t\t\t\t\t\t15.0 | \n\t\t\t\t\t\t
(1248, 1040) | \n\t\t\t\t\t\t\t5/6 | \n\t\t\t\t\t\t\t78. 4 | \n\t\t\t\t\t\t\t32. 1 | \n\t\t\t\t\t\t\t16.2 | \n\t\t\t\t\t\t
Throughput (Mbps) obtained in the parallel mode for the MSA.
For codes with
In multicore architectures, efficient parallel programming, both in terms of computation and memory accesses, represent a significant challenge. The Cell/B.E. is based on a distributed memory model where the problem of data collisions can decrease when properly handled by the programmer. The reported experimental results allow assessing the performance of LDPC decoders based on multicores. We have shown that for LDPC decoders running the SPA on the Cell/B.E., throughputs can range from 68 to nearly 70 Mbps [Falcão et al., 2009a]. Concerning the MSA, a more efficient solution is achieved producing throughputs that range from 72 to 80 Mbps [Falcão et al., 2008]. Regarding to non-scalable hardware dedicated ASIC solutions, which typically adopt 5 to 6-bit precision arithmetic [Liu, 2008], the parallel programmable architecture here proposed allows using 8-bit data precision or even more, which produces lower Bit Error Rates (BER) and superior coding gains as depicted in figure 8. The adoption of specific parallelization techniques on a low-cost multicore platform allowed us to achieve throughputs that approach well those obtained with ASIC-based solutions for WiMAX [Brack, 2006, Seo, 2007, Liu, 2008]. They also guarantee enough bandwidth for LDPC codes used in the WiMAX standard to work in worst case conditions.
\n\t\t\tBER curves for WiMAX codes (576, 288) and (1248, 624), considering both 6- and 8-bit data precision representations.
The advent of inexpensive multicore architectures has allowed to develop a novel programmable LDPC decoding solution for the WiMAX standard, with excellent throughputs, on the Cell/B.E. architecture. The LDPC decoder here presented exploits parallelism and data locality and is scalable to future generations of the Cell/B.E. architecture that are expected to have more SPEs, and should therefore improve the performance even further, processing more channels/subcarriers per second. The proposed decoder compares well with non-scalable and hardware-dedicated typical ASIC LDPC decoding solutions, reporting superior BER performances and throughputs above 72 Mbps.
\n\t\t\tOn going additional work related with LDPC decoders running on alternative parallel architectures can be found in [Falcão et al., 2009b; Seo et al., 2007].
\n\t\tThe real incidence of deep vein thrombosis is not fully known, due to the fact that the studies were depended only on clinical data (the majority of the reported cases had no clinical signs) without confirmation by laboratory and ultrasound findings. A further reason is that the referred studies investigated either DVT or PE and rarely both of the diseases [1, 2]. D-dimers have prognostic value only in 50% of cases of deep vein thrombosis or pulmonary embolism [3, 4]. Most of the published studies indicate that there is an increased risk of venous thrombosis when the travel duration is more than 4 h [3, 4]. Deep vein thrombosis is a serious health issue involving at least half a million Americans each year, and at least 1 in 10 will die suddenly. It depends on the mode of travel either by air flight company or car, bus, and train based fully on all travel-related risks of thrombosis. It is estimated that the risk of such an episode occurring during a long travel is 3–5%, with no reliable international accurate data [5, 6, 7, 8]. The reason for the increased risk of venous thrombosis is an exclusive phenomenon of all travel-related thromboses, which play a role in clot formation. Stasis during the journey, the pressure of the “narrow” seat on the vessels, dehydration, and maybe reduced oxygen saturation are some of the factors that symptoms of venous thrombosis or pulmonary embolism do not always appear immediately. They may occur up to 8 weeks after the travel [9, 10].
Regardless of whether it is a trip by car, train, bus, or plane, travel thrombosis (for flight travel also named “economy class syndrome”) will manifest up to 4 weeks after traveling according to the British Committee for Standards in Hematology up to 6 weeks after long-haul flights [9, 10]. It is estimated that 5–15% of all proven venous thromboembolism (VTE) occur in connection with long-haul flights [11, 12]. The risk is highest in the first week and then decreases continuously; the majority (approx. 60–75%) of all travel thrombosis are asymptomatic/low-symptom thrombosis exclusively located in the lower limbs, which is perceived as “unpleasant leg swelling/edema” due to long sitting with the legs hanging down [11, 12].
The clinical relevance of these asymptomatic thromboses is questionable, but they may be the origin for the manifestation of deep vein thrombosis. So far, there is no prospective, controlled study with a sufficient number of cases (adequate statistical power) that proves an evidence-based association between air travel and the risk of venous thromboembolism (VTE). In order to demonstrate a significantly increased risk, a study including around 1 million passengers (+ controls) would be necessary [13].
The risk for VTE mainly depends on the flight duration, the number of flights within 3–4 weeks, and risk factors of each individual predisposing to VTE. According to meta-analyses from case-control studies, long-haul flights increase the risk of VTE by two to four times within the first 4 weeks. For every 2 h of extended flight time, the VTE risk may increase by 26%. The risk of VTE is not increased in healthy passengers without risk factors and a flight duration of less than 3–4 h. It should be taken into account in this context that the basic risk for VTE in healthy women under 35 years without hormone intake is 1–2/10,000/years and increases fourfold after the age of 40 [13, 14, 15, 16]. Young women (<30 years) are up to three times more likely to experience VTE than young men. An observational study from France analyzed 116 pulmonary embolisms (PE) over a period of 13 years, which occurred immediately after landing. With approximately the same gender distribution of passengers, 78% of all PE affected women [13, 14, 15, 16]. Overall, the incidence of PE was 0.61/1,000,000 female passengers (0.2/1,000,000 male passengers). With a flight distance of more than 10,000 km, this risk rises to 7.2/1,000,000 female passengers. According to another study to 4.8/1,000,000 female passengers with a flight duration over 12 h, the total rate of VTE in healthy women without oral contraceptives is estimated 1/5000 regardless of the flight duration [13, 14, 15, 16].
At least 80% of all passengers (regardless of gender) have at least one identifiable risk factor for VTE (especially PE).
Air travel alone increases the risk of VTE by 1.8 (flight time 8–12 h) to 2.8 times (>12 h), factor V Leiden mutation by 13.6 times, and oral contraceptives even up to 40 times; BMI > 30 kg/m2 do not significantly increase the risk for air travelers. Already in 2003, Martinelli et al. referred to the increase in VTE risk on long-haul flights (>8 h) in connection with congenital and acquired thrombophilia (risk increase by 16 times) and oral contraceptives (risk increase by 14 times). According to a recent calculation model by Kuipers et al. based on data from a previous cohort study including employees from international companies, the estimated absolute risk for symptomatic VTE in women after long-distance flights (>4 h) and oral contraceptive use was 1/259 flights and with hormone replacement therapy 1/405 flights [2, 8, 17, 19].
The predisposing factors to VTE are mainly:
Individual or family history of VTE.
Presence of varicose veins.
Pregnancy and the first month after giving birth.
Oral estrogen-containing contraceptives: increased risk of VTE up to 20 times.
Recent surgery.
Cancer diseases.
Women with thrombophilia that had surgery or trauma within the last 3 months, taking oral contraceptives or being under hormone replacement therapy.
Obesity.
Height >1.90 or <1.60 m increased risk of VTE by 4–5 times [17, 18, 19].
Obese patients with body mass index (BMI) greater than 30 kg/m2 and risk of VTE increased by 10 times.
Travel participation can expose passengers to a variety of risk factors that may have impact on their health. Health professionals can obtain information from the International Maritime Health Association and Aerospace Medical Association website (www.imha.net and www.asma.org), respectively.
At a normal altitude of 36,000–40,000 feet, the cabin pressure equals that of 6000–8000 feet at sea level and is therefore at low levels resulting in a decrease in oxygen supply [20, 21, 22]. This is not dangerous for healthy people unless there are cardiopulmonary problems and hematological disorders, for example, sickle cell anemia. These problems are particularly pronounced when the airplane rises (because of the reduction in air pressure in the cabin, outflow from the middle ear and nasal cavities) and also during the cathode of the plane where there is an increase in air pressure in the cabin, inlet air, and the middle ear to balance the pressures. The reduced air humidity in the flight cabin of 10–20% (optimally 40–70%) in conjunction with other factors such as reduced drinking volume, excessive sweating, or increased diuresis due to increased alcohol/coffee consumption can promote the development of dehydration, respiratory diseases, and finally of deep vein thrombosis.
It is low in cabin <20% and can cause skin dryness and eye and nose discomfort. Moisturizing lotion and sunscreen are recommended, whereas contact lenses are contraindicated.
It is a form of oxygen with a different structure to its molecule located in the upper layers of the atmosphere and can irritate the upper respiratory system, but eyes and nose are decomposed by heat and eliminated by compressors.
There are no special effects for passengers on board of the flight. The total effective dose from natural radiation exposure in Germany averages 2.1 millisievert (mSv)/year. The International Commission on Radiological Protection recommends exposure of 1 mSv/year and 0.5 mSv/month as a guideline, within which there is no detectable risk of radiation damage. Internationally, radiation exposure during pregnancy of 1 mSv should not be exceeded totally, which is significantly lower than that associated with a potential health hazard (>20 mSv). The radiation exposure during air travel is clearly dependent on the route, altitude, and duration of the flight. The cosmic radiation in an altitude of 9–12 km is about 100 times higher than on the ground.
For short-haul flights (lower flight altitudes), a radiation exposure of on average 0.001–0.003 mSv/h and for long-haul flights (higher altitude, other flight route) of 0.005–0.008 mSv/h have been determined.
It does not occur regularly except in case of atmospheric disturbances. If predisposed it is prudent to avoid alcohol and to supply appropriate medicines.
Nearly 50% of the passengers with DVT of one or more extremities may be asymptomatic. However, edema of the limb, pain, and signs as red and hot to touch skin are some of the symptoms. Unspecific symptoms of pulmonary embolism may be present, such as unexplained dyspnea, abnormal heart rhythm, chest pain, intolerance that may be aggravated by coughing or deep inhalation, coughing up blood, anxiety, dizziness, or a tendency to faint. Especially, people in high-risk groups should be informed about early recognition of these symptoms in order to seek for medical help. Preventive measures include sufficient hydration, avoidance of alcohol/excessive caffeine intake, and regular walking during the trip.
The risk of VTE is eightfold increased in patients with the factor V Leiden mutation that affects blood clotting. These passengers should be considered for heparin prophylaxis. According to the French Society of Cardiology, the probability of venous thrombosis during an airline flight is multiplied by 2.81 in a healthy person, regardless of flight time. The risk is then increased by 26% for every 2 h of flight. Before traveling it is prudent to take the following recommendations into consideration:
Wear comfortable clothing, leave space under the front seat to allow mobility of the lower legs, change posture regularly, do exercises for feet regularly, and book aisle seat, if you are predisposed to VTE.
Walk regularly every 60–90 min, and drink a sufficient amount of fluids (at least 150–200 ml every 2 h) which is especially important for people at increased risk of thrombosis. In these passengers well-fitted elastic compression stockings until the knee are recommended and in high-risk passengers additionally the subcutaneous administration of low molecular weight heparin 2–6 h before traveling.
It is estimated that there is 1 pregnant woman per 1000 air travelers. Reliable data on the incidence of VTE in pregnant women with long-haul flights are so far not available. Considering an approximately fivefold increased risk of VTE during pregnancy (compared to nonpregnant women), various calculation models by Cannegieter and Rosendaal have shown an estimated incidence of venous thrombosis of 0.03–0.1% after one air travel in pregnancy. According to a cohort study including a small number of cases (26 thrombosis, 3 of them are pregnant women), the OR for DVT with air travel and pregnancy was 14.3 (95% CI, 1.7–121.0), corresponding to an estimated absolute risk of 1/109 flights [2, 23, 24, 25].
Overall, the absolute risk of VTE during pregnancy is 1–2/1000 pregnancies. This risk increases by fivefold in the puerperium. 20.4% of VTE manifest in the first, 20.9% in the second, and 58.7% in the third trimester; 95% of all postnatal VTE occur within 6 weeks postpartum. The risk of VTE in the puerperium is 20–80 times higher than that in nonpregnant women. Due to the increased production of coagulation factors and a reduction in fibrinolytic activity, hypercoagulability occurs in physiological pregnancy. Healthy pregnant women compensate this hypercoagulable state by pregnancy-induced hemodilution and the increased perfusion in microcirculation. According to the risk classification for VTE by Andersen and Spencer, pregnancy and the puerperium were considered as moderate risk for VTE (OR between 2 and 9), even in connection with long-haul flights [2, 23, 24, 25].
According to RCOG Guideline No. 37a 2015, air travel of more than 4 hours is an independent risk factor for VTE (evidence level III). This risk increases with additional individual risk factors for VTE which have to be considered in the consulting practice (overview at risk factors for VTE associated with air travel). Regardless of pregnancy, the following “thrombogenic” factors were discussed in connection with long-haul flights.
Long-term immobilization with sitting for hours in a “cramped” posture (especially kinking of the legs and pressure of the edge of the seat on the popliteal veins) may promote venous stasis in the lower extremities. Air travelers over 190 cm and under 160 cm height are particularly at risk. In this context, it should be mentioned that sitting by the window is associated with a twofold higher risk of VTE than sitting at the aisle. In passengers, with a BMI over 30, the risk of VTE is increased even by sixfold. Significant differences regarding the risk of thrombosis (measurement of the D-dimers) between the first/business class and the economy class have not yet been demonstrated; however, related data are limited [26, 27, 28, 29].
Other risk factors associated with air travel are dehydration, reduced air pressure and humidity in the aircraft cabin, disruption of circadian rhythm and hypobaric hypoxia and their effects on changes in the coagulation system [30, 31].
So far there are no evidence-based recommendations for the prevention of VTE during air travel, but there are some based on expert consensus (mostly grade D) in various international guidelines. Only the RCOG Scientific Impact Paper No. 1 from 2013 and the ACOG Committee Opinion No. 443 of 2009 explicitly address air travel and pregnancy. A decisive prerequisite for adequate prevention (especially for pregnant women) is a careful individual assessment of risk factors by the doctor (gynecologist/family doctor) before starting the flight. This provides the basis for risk-adapted thromboembolism prophylaxis. A total of five guidelines make risk-related recommendations including risk classification for VTE after air travel [26, 27, 28, 29].
According to the AWMF guideline 003/001 (S3), long air flights or bus trips do not require any special prophylaxis measures apart from general basic measures; in individual cases when there are risk factors, calf-length compression stockings should be considered.
If the risk is low, general measures are enough. With intermediate risk, e.g., pregnancy/puerperium, in addition to the general measures from a flight duration of 4 h, the wearing of graduated compression stockings up to the knee is recommended. The importance of compression stockings for thrombosis prophylaxis on long-haul flights (>4 h) also emerges from a 2006 Cochrane analysis (revised 2010) including 10 randomized trials [26, 27, 28, 29, 30, 31, 32, 33].
The scientific studies (n = 2856) with moderate quality and different risk profiles for VTE were considered. The primary outcome criterion of this analysis was the rate of symptomatic and asymptomatic (diagnosed by sonography or phlebography) deep vein thrombosis. Wearing well-fitted compression stockings has shown to reduce the rate of asymptomatic deep vein thrombosis from 3.6 to 0.2% (OR 0.10; 95% CI 0.04–0.25; p < 0.00001); in addition, the frequency of leg edema was also significantly shown to be significantly decreased as reported by the LONFLIT-4 study [26, 27, 28, 29, 30, 31, 32, 33, 34, 35].
If there is a high risk of VTE, in addition to compression stockings, the prophylactic subcutaneous administration of low-molecular heparin (LMH) after individual risk assessment should be considered; aspirin is not indicated in these cases [26, 27, 28, 29, 30, 31, 32, 33].
Severe anemia <7.5 g/dl; otitis media and sinusitis; severe heart and lung diseases; recent gastrointestinal surgery, including laparoscopic surgery; bone fractures; risk of leg swelling, especially in the first few days after wearing one plaster cast; referred fear of flying are contraindications for air traveling [26, 27, 28, 29, 30, 31, 32, 33, 34, 35].
It goes without saying that unclear symptoms such as bleeding, abdomen pain, gastrointestinal symptoms, or clinical signs of preeclampsia or thrombosis must be clarified before traveling, especially since most airlines issues demand a medical certificate about the safety air of travel. The 2nd trimester, especially the interval between the 18th and 24th week of gestation, is considered the safest time to travel because the risk of obstetric complications (e.g., premature labor) is lowest at this time. In the third trimester, pregnancy risks, such as preeclampsia, intrauterine growth restriction, antenatal bleeding due to placenta previa, severe anemia, and the increased risk of premature birth (previous preterm birth, recurrent premature labor, and cervical insufficiency), should be excluded prior to the flight. Most airlines allow pregnant women with uncomplicated single pregnancy to travel up to (and including) 36th week of pregnancy and women with uncomplicated multiple-child pregnancy up to 32nd week of pregnancy, which is in accordance with the regulations of the International Air Travel Association. As shown in previous studies, there are still no uniform regulations for the transportation of pregnant passengers in civil aviation. It is therefore advisable to check the relevant conditions of carriage of the different airlines on their website before each flight; this also applies to the certification obligations. In addition, information about the destination/place of residence should be obtained before starting the flight, in particular about the climate, altitude, humidity, risk of infection, etc., and about the medical/obstetric (emergency) care on site [26, 27, 28, 29, 30, 31, 32, 33, 34, 35].
“Premature placental abruption” due to manifestation of contractions.
“Cervical insufficiency” premature labor, premature bladder jump.
“Suspected ectopic pregnancy”.
“Vaginal bleeding”.
“Impending abortion”.
“Preeclampsia” (previous/current pregnancy).
The association between air travel and pregnancy outcome concerning early or late pregnancy loss, incidence of malformations placenta abruption, etc. is very limited. The average altitude for commercial long-haul flights is 10,000–12,500 m. The air pressure drops from 760 mmHg (at sea level) to 560 mmHg at flight level. This drop-in air pressure is largely compensated for by the cabin pressure in the aircraft (equivalence to an altitude of 1524–2438 m above sea level) so that an altitude of about 12,200 m is tolerated by the passengers without hypoxic stress. The partial pressure of oxygen in the arterial blood depends on the lung function (cave: chronic obstructive pulmonary diseases); in healthy passengers it drops from 95 mmHg to 53–78 mmHg in the airplane, and the arterial oxygen saturation decreases from 97 to 99% to 90–94% [36, 37, 38, 39, 40, 41].
For healthy pregnant women who have sufficient oxygen saturation, this “relative” hypoxia in the plane poses no significant risk even for a healthy fetus. No influence on the fetal heart rate during short-haul flights was observed [30, 31, 42]. Due to the approximately 50% higher hemoglobin concentration compared to the mother, the 20–30% higher oxygen affinity of fetal hemoglobin and the Bohr effect which guarantees a preferred oxygen release on the placental level, and negative effects on the fetuses are not to be feared. There is no need to fear mild hypoxia associated with air travel. However, this does not apply to pregnant women with reduced oxygen saturation due to underlying diseases (e.g., severe anemia, chronic obstructive pulmonary diseases) [41, 42, 43, 44, 45, 46, 47, 48].
In general, a general attest must be introduced for the transportation of all pregnant passengers from the child’s extrauterine viability, i.e., from the 25th week of pregnancy. The certificate should be issued in the period from approximately 1 week to 2 days before departure in order to guarantee that it is up to date to some extent. In addition to the exact gestational age, risks must also be specified which should be related to the health risk for both the mother and the child, and a distinction between single and multiple pregnancies should be documented. Concerning multiple pregnancies, long-haul flights up to the 28th week of pregnancy or short-haul flights up to the 32nd week of pregnancy in these cases are recommended to prevent premature birth. Short-haul flights are those routes on which an airport can be reached within 1 hour. Considering the average duration of pregnancy and birth in the case of single pregnancies, transport on long-haul flights up to the 36th week of pregnancy and on short-haul flights up to the 37th week of pregnancy is possible [41, 42, 43, 44, 45, 46, 47, 48].
For all traveling people, the risk of VTE is slightly increased. It is significantly increased in passengers who have particular risk factors such as advanced age, taking estrogen-containing oral contraceptives or are at hormonal replacement therapy, obesity, and the presence of factor V Leiden mutation, at most high or very low body height [49, 50, 51, 52].
The underlying mechanism responsible for travel-related thrombosis is not fully understood. But the fact that risk has been found for all modes of travel suggests that immobility and associated venous stasis may be a key factor in generating the disease. The reduction of oxygen levels may be an additional reason for the initiation of thrombus formation during long air travel in groups of people with specific risk factors.
Additional abovementioned thrombogenic risk factors increase the risk of VTE significantly.
Low air pressure and reduced blood oxygenation increase the risk of deep vein thrombosis in susceptible air passengers.
To date, deep vein thrombosis in air passengers has been mainly associated with the fact that they have been stationary for long periods of time as is usually the case in air travel.
Deep vein thrombosis occurs in the lower limbs when there are long periods of inactivity or sedentary activity.
The risk is that the clot can move through the bloodstream to the heart, lungs, and brain. This can happen hours, days, or weeks later after the initial formation of thrombosis. It is the cause of a heart attack or stroke.
Studies have shown that the risk of deep vein thrombosis of the lower limbs increases by two to four times after an air trip [49, 50, 51, 52].
They believe that the main culprit is the hypoxia of blood resulting from low cabin pressure and reduced oxygen levels of passengers compared to what is happening on the ground. The decrease in oxygen concentration in the blood seems to activate the coagulation system leading to the formation of clots.
In addition, this research provides us with important information about who is at greater risk than others.
These include people carrying the Leiden-type factor V mutant of the blood coagulation system, women taking birth control pills, patients recently undergoing surgery, and some groups of cancer patients.
High-risk patients may be prescribed anticoagulant medicines such as aspirin, heparin, dipyridamole, clopidogrel (Plavix®), and others after medical evaluation and advice.
In addition, alcohol should be avoided in the flight, and passengers should be able to stretch their legs and do as much exercise and walking as possible. They can also wear special socks. These measures improve blood circulation and help prevent thrombosis and its consequences.
Air travel can cause clots of the deep veins of the thigh and feet [49, 50, 51, 52].
This thrombosis can in turn cause a pulmonary embolism which is a very serious condition which can cause death.
Thrombosis in the lower limbs (thighs, ankles, legs) is due to thickening phenomena that occur in the deep long veins due to the many hours that passengers remain seated.
Lack of physical movement, dehydration observed in passengers, and alcohol consumption in flight are considered to be among the factors contributing to the occurrence of dangerous thrombotic conditions and pulmonary embolism.
In addition, some people may have inherited diseases with an increased risk of thrombosis and thus be at greater risk than air travel.
To date, 100 cases of pulmonary embolism due to venous thrombosis of the lower limbs have been described. A significant number of cases have died due to this condition. A case of lower limb amputation due to thrombosis has recently been described.
Research shows that clotting problems occur in the lower limbs and in up to 10% of long-haul passengers.
In fact, this syndrome is called by some people the “financial position” syndrome because passengers in these places do not have enough space in front of them to move their legs and remain motionless for many hours.
Researchers believe the incidence of pulmonary embolism after a long plane trip is higher.
The reason they are not detected is because the passengers are not immediately aware of what is happening or because the clinical signs are manifesting themselves severely a few hours after disembarkation. Even sudden deaths on flights or on landings may be due to a pulmonary embolism.
Some even argue that the problem is even greater and that the incidents detected constitute a very small percentage of those occurring.
Passengers should drink plenty of water to eliminate the risk of dehydration.
Avoid drinking alcohol and excessive caffeine intake.
Passengers should be able to get up, walk, do small exercises, or even stretch or move their lower limbs. It is also not good to cross legs.
Patients with a personal or family history of thrombosis should consult their physicians prior to an air trip [5, 52, 53, 54].
Some researchers recommend that passengers wear special high-pressure socks to improve blood circulation to the lower limbs. This is especially true for people at increased risk for thrombosis.
For some passengers, taking low doses of aspirin before a long flight can be beneficial.
The World Health Organization recommends [5, 52, 53, 54, 55] the following:
Do not leave space under the front seat to allow for freedom of movement for the lower extremities.
Exercises for feet.
Often stop by car to walk, or get up regularly for a bit of unwinding and walking on an airplane, train, or boat.
Do not drink too much water and avoid drinking alcohol.
For persons at high risk of thrombosis, elastic compression with special socks and sometimes administration of low molecular weight heparin are recommended (2–6 h before travel). The aspirin intake is controversial.
The mechanisms that have been implicated to date for this phenomenon are venous posture due to prolonged sitting posture, pressure exerted on the large vein behind the knee, blood buildup due to reduced intake and increased fluid loss, abnormalities in the system, and blood coagulation created in the subarctic and hypoxic environment.
Air travel or road trips, for many hours, run the risk of vein thrombosis in the legs and even more severe, pulmonary embolism. Posttraumatic thrombosis accounts for about 10% of all thromboses that occur.
According to the American College of Chest Physicians (ACCP) (2012) British Committee for Standards in Hematology (BCSH) (2011), British Thoracic Society (BTS) (2011) Traveler’s thrombosis: International Consensus Statement (Wien 2008) [21, 57, 58, 59], low-risk, medium-risk, and high-risk factors for VTE after air travel are as follows:
No individual risk factors other than long-haul flights (ACCP, >6 h; BCSH, >6 h; BTS, >8 h/several flights in a short time (approx. 4 weeks)).
Previous provoked VTE.
Thrombophilia.
BMI >30 kg/m2.
Positive family history for VTE.
Pronounced varicose.
Combined oral contraceptives.
Hormone replacement therapy.
Pregnancy.
Puerperium: within 2 weeks (BTS) orup to 6 weeks (BCSH) postpartum.
Height >190 cm/<160 cm (BTS).
Previous idiopathic VTE.
Cancer.
Major surgery/trauma within.
The last 4–6 weeks.
Severe underlying diseases.
Immobilization (e.g., plaster cast).
Homozygous or combined congenital thrombophilia.
≥2 risk factors under B.
Recommendations for the prevention of deep leg vein thrombosis on long-haul flights are as follows:
General measures:
Physical activity: regular walking around in the corridor every 2–3 h.
Movement of the legs (calf muscles, e.g., “foot rocker”) at the seat.
All 30 min, isometric exercises.
Sitting in the aisle (freedom of movement):
Feet should reach the floor.
Cave: bending the popliteal veins.
Avoid dehydration:
Regular liquid intake (at least 250 ml every 2 h).
No excessive alcohol/coffee enjoyment.
Do not take tranquilizers/sleeping pills:
Cave: prolonged sleep in a cramped posture.
Pregnancy, puerperium.
Customized, graduated compression stockings to the knee (15–30 mmHg compression in ankle).
Previous VTE, symptomatic thrombophilia.
Additional (grade 2C/2D):
Low molecular weight heparin (e.g., 5000 IU dalteparin s.c.) 6–12 h before the flight and 1–3 days after the flight (individual decision).
No aspirin.
Clots can be formed at various points, in the legs and in the thighs, with similar problems. All veins have valves every 10–12 cm, and some of them can form clots.
If the clot stays there, then the member has swelling and pain. Small fever may occur, and the member may be warmer. The most serious complication, however, is pulmonary embolism (PE), which occurs in 25% of cases with thrombosis. If the clot is detached, it is transported through the veins and eventually clamped to the lung. The condition can appear immediately or even 2 weeks after the long journey. The most common symptoms to suspect pulmonary embolism are sudden chest pain, dyspnea, dizziness, fever, hemoptysis, etc. Symptoms depend on the size of the plunger and the size of the vessel, the age of the person, if he or she is suffering from other diseases, etc. Immediate admission to the hospital is required for diagnosis and special treatment. In rare cases, a part of the clot can cause embolism in other organs, such as the brain.
People predisposed to thrombosis, as well as patients with previously mentioned illnesses, should be consulted by their physician prior to long journeys. In these individuals, it is recommended to inject antithrombotic (heparin) once 24 h before flight. It is also recommended to take aspirin before takeoff, except for pregnant women who are not allowed [5, 53, 54, 55, 56].
Wear comfortable clothing.
Leave space under the front seat to allow freedom of movement for the lower legs.
Change your posture regularly and do exercises for your feet.
Take regular breaks to walk.
Drink plenty of liquids.
For persons at high risk of thrombosis, elastic compression with special socks is recommended and sometimes administration of low molecular weight heparin (2–6 h before travel).
People suffering from diseases that increase the risk of venous thromboembolism should follow the guidelines above, and the possibility of administering low molecular weight heparin (2–4 h before or earlier before flying) may also be considered.
In patients receiving anticoagulants, the dose should be reassessed.
Overall, however, there is insufficient data on pregnancy complications after air travel.
Occasional air travel, especially in the second trimester, is safe for healthy pregnant women and their child, according to the current state of knowledge, and has no negative effects on the course of pregnancy. Before starting the flight, the gynecologist should carefully ascertain the patient’s own (pre-existing illnesses) and obstetric history, as well as individually check the previous course of pregnancy (pregnancy-related risks) to identify pregnant women with risk factors who are advised against traveling by air. In any case, it is advisable to consider the different conditions of carriage of the airlines (including mandatory certification) and to obtain information about the destination of the flight. A drop-in air pressure, a reduction in partial oxygen pressure, and air humidity are generally not a problem for healthy pregnant women and their children. Dehydration during long-haul flights should be avoided. A radiation dose of 1 mSV should not be exceeded during pregnancy; pregnant women with frequent long-haul flights near the pole (e.g., Europe-North America) should take care of this. Most people believe that commercial air travel does not increase the risk of pregnancy complications (e.g., premature birth) in healthy pregnant women [5, 53, 54, 55, 56, 57, 60].
The estimated radiation dose for infants/toddlers should be 0.05 μSV/scan, which for the fetuses are negligible [61].
Travel thrombosis in connection with long-haul flights (>4 h flight time) are rare (about 1/4500 passengers) and mostly affect the deep veins of the calf muscles. The proportion of pulmonary embolisms is significantly higher for female passengers than for male passengers (flight duration > 12 h: 4.8–7.2/1 million). The risk of venous thromboembolism depends primarily on the duration of the flight, the number of flights within 4 weeks, and individual thrombogenic risk factors. As a result of hypercoagulability and venous stasis, the risk for pregnant women is increased, and it is estimated at 0.03–0.1%. Long-term immobilization is the most important predisposing factor; the importance of hypobaric hypoxia and dehydration is controversial.
Before starting the flight, especially pregnant women are advised to carefully assess their risks. To reduce risk, in addition to general measures (e.g., physical activity), wearing graded, well-fitting compression stockings is recommended and if there is a high individual risk (e.g., previous VTE), prophylaxis administration of low molecular weight heparin before and immediately after the flight.
These Terms and Conditions outline the rules and regulations pertaining to the use of IntechOpen’s website www.intechopen.com and all the subdomains owned by IntechOpen located at 5 Princes Gate Court, London, SW7 2QJ, United Kingdom.
',metaTitle:"Terms and Conditions",metaDescription:"These terms and conditions outline the rules and regulations for the use of IntechOpen Website at https://intechopen.com and all its subdomains owned by Intech Limited located at 7th floor, 10 Lower Thames Street, London, EC3R 6AF, UK.",metaKeywords:null,canonicalURL:"/page/terms-and-conditions",contentRaw:'[{"type":"htmlEditorComponent","content":"By accessing the website at www.intechopen.com you are agreeing to be bound by these Terms of Service, all applicable laws and regulations, and agree that you are responsible for compliance with any applicable local laws. Use and/or access to this site is based on full agreement and compliance of these Terms. All materials contained on this website are protected by applicable copyright and trademark laws.
\\n\\nThe following terminology applies to these Terms and Conditions, Privacy Statement, Disclaimer Notice, and any or all Agreements:
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\\n\\n“Party”, “Parties”, or “Us”, refers to both the Client and ourselves, or either the Client or ourselves.
\\n\\nAll Terms refer to the offer, acceptance, and consideration of payment necessary to provide assistance to the Client in the most appropriate manner, whether by formal meetings of a fixed duration, or by any other agreed means, for the express purpose of meeting the Client’s needs in respect of provision of the Company’s stated services/products, and in accordance with, and subject to, the prevailing laws of the United Kingdom.
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\\n"}]'},components:[{type:"htmlEditorComponent",content:'By accessing the website at www.intechopen.com you are agreeing to be bound by these Terms of Service, all applicable laws and regulations, and agree that you are responsible for compliance with any applicable local laws. Use and/or access to this site is based on full agreement and compliance of these Terms. All materials contained on this website are protected by applicable copyright and trademark laws.
\n\nThe following terminology applies to these Terms and Conditions, Privacy Statement, Disclaimer Notice, and any or all Agreements:
\n\n“Client”, “Customer”, “You” and “Your” refers to you, the person accessing this website and accepting the Company’s Terms and Conditions;
\n\n“The Company”, “Ourselves”, “We”, “Our” and “Us”, refers to our Company, IntechOpen;
\n\n“Party”, “Parties”, or “Us”, refers to both the Client and ourselves, or either the Client or ourselves.
\n\nAll Terms refer to the offer, acceptance, and consideration of payment necessary to provide assistance to the Client in the most appropriate manner, whether by formal meetings of a fixed duration, or by any other agreed means, for the express purpose of meeting the Client’s needs in respect of provision of the Company’s stated services/products, and in accordance with, and subject to, the prevailing laws of the United Kingdom.
\n\nAny use of the above terminology, or other words in the singular, plural, capitalization and/or he/she or they, are taken as interchangeable.
\n\nUnless otherwise stated, IntechOpen and/or its licensors own the intellectual property rights for all materials on www.intechopen.com. All intellectual property rights are reserved. You may view, download, share, link and print pages from www.intechopen.com for your own personal use, subject to the restrictions set out in these Terms and Conditions.
\n\nWe employ the use of cookies. By using the IntechOpen website you consent to the use of cookies in accordance with IntechOpen’s Privacy Policy. Most modern day interactive websites use cookies to enable the retrieval of user details for each visit. On our site, cookies are predominantly used to enable functionality and ease of use for those visiting the site.
\n\nIn no circumstances shall IntechOpen or its suppliers be liable for any damages (including, without limitation, damages for loss of data or profit, or due to business interruption) arising out of the use, or inability to use, the materials on IntechOpen's websites, even if IntechOpen or an IntechOpen authorized representative has been notified orally or in writing of the possibility of such damage. Some jurisdictions do not allow limitations on implied warranties, or limitations of liability for consequential or incidental damages; consequently, these limitations may not apply to you.
\n\nIntechopen.com website content and services are provided on an "AS IS" and an "AS AVAILABLE" basis. Material appearing on www.intechopen.com could include minor technical, typographical, or photographic errors. IntechOpen may make changes to any material contained on its website at any time without notice.
\n\nIntechOpen has no formal affiliation to any external sites that link to www.intechopen.com, unless otherwise specifically stated. As such, it is not responsible for content that appears on any such sites. The inclusion of any link to IntechOpen does not imply endorsement by IntechOpen. Use of any such linked website is done solely at the user's own discretion.
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\n\nWithout prior approval and express written permission, you may not create frames around our web pages or use other techniques that alter in any way the visual presentation or appearance of our website.
\n\nIntechOpen may revise its Terms of Service for its website at any time without notice. By using this website, you are agreeing to be bound by the current version of all Terms at the time of use.
\n\nThese Terms and Conditions are governed by and construed in accordance with the laws of the United Kingdom and you irrevocably submit to the exclusive jurisdiction of the courts in London, United Kingdom.
\n\nCroatian version of Terms and Conditions available here
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MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"46296",doi:"10.5772/57398",title:"Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity",slug:"physiological-role-of-amyloid-beta-in-neural-cells-the-cellular-trophic-activity",totalDownloads:5943,totalCrossrefCites:19,totalDimensionsCites:32,abstract:null,book:{id:"3846",slug:"neurochemistry",title:"Neurochemistry",fullTitle:"Neurochemistry"},signatures:"M. del C. Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. Gómez-Virgilio, G. Ramírez-Rodríguez, E. Vera-\nArroyo, R. Fiorentino-Pérez, U. García, J. Luna-Muñoz and M.A.\nMeraz-Ríos",authors:[{id:"42225",title:"Dr.",name:"Jose",middleName:null,surname:"Luna-Muñoz",slug:"jose-luna-munoz",fullName:"Jose Luna-Muñoz"},{id:"114746",title:"Dr.",name:"Marco",middleName:null,surname:"Meraz-Ríos",slug:"marco-meraz-rios",fullName:"Marco Meraz-Ríos"},{id:"169616",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Cardenas-Aguayo",slug:"maria-del-carmen-cardenas-aguayo",fullName:"Maria del Carmen Cardenas-Aguayo"},{id:"169857",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Silva-Lucero",slug:"maria-del-carmen-silva-lucero",fullName:"Maria del Carmen Silva-Lucero"},{id:"169858",title:"Dr.",name:"Maribel",middleName:null,surname:"Cortes-Ortiz",slug:"maribel-cortes-ortiz",fullName:"Maribel Cortes-Ortiz"},{id:"169859",title:"Dr.",name:"Berenice",middleName:null,surname:"Jimenez-Ramos",slug:"berenice-jimenez-ramos",fullName:"Berenice Jimenez-Ramos"},{id:"169860",title:"Dr.",name:"Laura",middleName:null,surname:"Gomez-Virgilio",slug:"laura-gomez-virgilio",fullName:"Laura Gomez-Virgilio"},{id:"169861",title:"Dr.",name:"Gerardo",middleName:null,surname:"Ramirez-Rodriguez",slug:"gerardo-ramirez-rodriguez",fullName:"Gerardo Ramirez-Rodriguez"},{id:"169862",title:"Dr.",name:"Eduardo",middleName:null,surname:"Vera-Arroyo",slug:"eduardo-vera-arroyo",fullName:"Eduardo Vera-Arroyo"},{id:"169863",title:"Dr.",name:"Rosana Sofia",middleName:null,surname:"Fiorentino-Perez",slug:"rosana-sofia-fiorentino-perez",fullName:"Rosana Sofia Fiorentino-Perez"},{id:"169864",title:"Dr.",name:"Ubaldo",middleName:null,surname:"Garcia",slug:"ubaldo-garcia",fullName:"Ubaldo Garcia"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9753,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7206,totalCrossrefCites:6,totalDimensionsCites:27,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1473,totalCrossrefCites:13,totalDimensionsCites:25,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:193348,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4632,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3565,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3622,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1370,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82953",title:"Early Visual Areas are Activated during Object Recognition in Emerging Images",slug:"early-visual-areas-are-activated-during-object-recognition-in-emerging-images",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105756",abstract:"Human observers can reliably segment visual input and recognise objects. However, the underlying processes happen so quickly that they normally cannot be captured with fMRI. We used Emerging Images (EI), which contains a hidden object and extends the process of recognition, to investigate the involvement of early visual areas (V1, V2 and V3) and lateral occipital complex (LOC) in object recognition. The early visual areas were located with a retinotopy scan and the LOC with a localiser. The participants (N=8) then viewed an EI, followed by the hidden object’s silhouette (disambiguation), and then, the EI was repeated. BOLD responses before and after disambiguation were compared. The retinotopy parameters were used to back-project the BOLD response onto the visual field, creating spatially detailed maps of the activity change. V1 and V2 (but not V3) showed stronger response after disambiguation, while there was no difference in the LOC. The back-projections revealed no distinct pattern or changes in activity on object location, indicating that the activity in V1 and V2 is not specific for voxels corresponding to the object location. We found no difference before and after disambiguation in the LOC, which may be repetition suppression counteracting the effect of recognition.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Marleen Bakker, Hinke N. Halbertsma, Nicolás Gravel, Remco Renken, Frans W. Cornelissen and Barbara Nordhjem"},{id:"82931",title:"Neuroinflammation in Traumatic Brain Injury",slug:"neuroinflammation-in-traumatic-brain-injury",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.105178",abstract:"Neuroinflammation following traumatic brain injury (TBI) is an important cause of secondary brain injury that perpetuates the duration and scope of disease after initial impact. This chapter discusses the pathophysiology of acute and chronic neuroinflammation, providing insight into factors that influence the acute clinical course and later functional outcomes. Secondary injury due to neuroinflammation is described by mechanisms of action such as ischemia, neuroexcitotoxicity, oxidative stress, and glymphatic and lymphatic dysfunction. Neurodegenerative sequelae of inflammation, including chronic traumatic encephalopathy, which are important to understand for clinical practice, are detailed by disease type. Prominent research topics of TBI animal models and biomarkers of traumatic neuroinflammation are outlined to provide insight into the advances in TBI research. We then discuss current clinical treatments in TBI and their implications in preventing inflammation. To complete the chapter, recent research models, novel biomarkers, and future research directions aimed at mitigating TBI will be described and will highlight novel therapeutic targets. Understanding the pathophysiology and contributors of neuroinflammation after TBI will aid in future development of prophylaxis strategies, as well as more tailored management and treatment algorithms. This topic chapter is important to both clinicians and basic and translational scientists, with the goal of improving patient outcomes in this common disease.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Grace Y. Kuo, Fawaz Philip Tarzi, Stan Louie and Roy A. Poblete"},{id:"82876",title:"Oxygen Tissue Levels as an Effectively Modifiable Factor in Alzheimer’s Disease Improvement",slug:"oxygen-tissue-levels-as-an-effectively-modifiable-factor-in-alzheimer-s-disease-improvement",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.106331",abstract:"Despite the advance in biochemistry, there are two substantial errors that have remained for at least two centuries. One is that oxygen from the atmosphere passes through the lungs and reaches the bloodstream, which distributes it throughout the body. Another major mistake is the belief that such oxygen is used by the cell to obtain energy, by combining it with glucose. Since the late nineteenth century, it began to be published that the gas exchange in the lungs cannot be explained by diffusion. Even Christian Bohr suggested that it looked like a cellular secretion. But despite experimental evidence to the contrary and based only on theoretical models, the dogma that our body takes the oxygen it contains inside from the air around it has been perpetuated to this day. The oxygen levels contained in the human body are high, close to 99%, and the atmosphere only contains between 19 and 21%. The hypothesis that there is a supposed oxygen concentrating mechanism has not been experimentally proven to date, after almost two centuries. The mistaken belief, even among neurologists, that our body takes oxygen from the atmosphere is widespread, even though there is no experimental basis to support it, just theoretical models. Our finding that the human body can take oxygen from the water it contains, not from the air around it, like plants, comes to mark a before and after in biology in general, and the CNS is no exception. Therefore, establishing the true origin of the oxygen present within our body and brain will allow us to better understand the physio pathogenesis of neurodegenerative diseases.",book:{id:"11637",title:"Neuropsychology of Dementia",coverURL:"https://cdn.intechopen.com/books/images_new/11637.jpg"},signatures:"Arturo Solís Herrera"},{id:"82859",title:"Impact of Hypoxia on Astrocyte Induced Pathogenesis",slug:"impact-of-hypoxia-on-astrocyte-induced-pathogenesis",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.106263",abstract:"Astrocytes are the most abundant cells of the central nervous system. These cells are of diverse types based on their function and structure. Astrocyte activation is linked mainly with microbial infections, but long-term activation can lead to neurological impairment. Astrocytes play a significant role in neuro-inflammation by activating pro-inflammatory pathways. Activation of interleukins and cytokines causes neuroinflammation resulting in many neurodegenerative disorders such as stroke, growth of tumours, and Alzheimer’s. Inflammation of the brain hinders neural circulation and compromises blood flow by affecting the blood–brain barrier. So the oxygen concentration is lowered, causing brain hypoxia. Hypoxia leads to the activation of nuclear factor kappa B (NFkB) and hypoxia-inducible factors (HIF), which aggravates the inflammatory state of the brain. Hypoxia evoked changes in the blood–brain barrier, further complicating astrocyte-induced pathogenesis.",book:{id:"10744",title:"Astrocytes in Brain Communication and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10744.jpg"},signatures:"Farwa Munir, Nida Islam, Muhammad Hassan Nasir, Zainab Anis, Shahar Bano, Shahzaib Naeem, Atif Amin Baig and Zaineb Sohail"},{id:"82839",title:"Neurophysiology of Emotions",slug:"neurophysiology-of-emotions",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.106043",abstract:"Emotions are automatic and primary patterns of purposeful cognitive-behavioral organizations. They have three main functions: coordination, signaling, and information. First, emotions coordinate organs and tissues, thus predisposing the body to peculiar responses. Scholars have not reached a consensus on the plausibility of emotion-specific response patterns yet. Despite the limitations, data support the hypothesis of specific response patterns for distinct subtypes of emotions. Second, emotional episodes signal the current state of the individual. Humans display their state with verbal behaviors, nonverbal actions (e.g., facial movements), and neurovegetative signals. Third, emotions inform the brain for interpretative and evaluative purposes. Emotional experiences include mental representations of arousal, relations, and situations. Every emotional episode begins with exposure to stimuli with distinctive features (i.e., elicitor). These inputs can arise from learning, expressions, empathy, and be inherited, or rely on limited aspects of the environment (i.e., sign stimuli). The existence of the latter ones in humans is unclear; however, emotions influence several processes, such as perception, attention, learning, memory, decision-making, attitudes, and mental schemes. Overall, the literature suggests the nonlinearity of the emotional process. Each section outlines the neurophysiological basis of elements of emotion.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Maurizio Oggiano"},{id:"82172",title:"Neuroimaging in Common Neurological Diseases Treated by Anticoagulants",slug:"neuroimaging-in-common-neurological-diseases-treated-by-anticoagulants",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105128",abstract:"Stroke imaging/Cerebral Venous sinus thrombosis/Arterial dissecting disease in Head and Neck regions/Neurocomplication of anticoagulation therapy. Nowsday, anticoagulant drugs are common drugs used in daily practice for patients in neurology clinic. Anticoagulant treatment used for treated symptomatic patients as well as for prophylaxis therapy in asymptomatic patients. The purpose of this chapter based on the review of essential neuroimaging in the most common neurological conditions that benefit from treatment with anticoagulant drugs such as ischemic stroke, cerebral venous sinus thrombosis, and arterial dissecting disease of head and neck arteries and will be enclosed with neuroimaging in case of neurocomplication by anticoagulant therapy.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Pipat Chiewvit"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is on the editorial board of several international peer-reviewed journals and has published many papers. Additionally, he has participated in many international and national congresses, seminars, and workshops with oral and poster presentations. He is an active member of many local and international organizations.",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",country:{name:"Turkey"}}},{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",biography:"Dr. Sergey Tkachev is a senior research scientist at the Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia, and at the Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. 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In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. 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Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. 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