\n\t\t\t\t\t\t\tTable 1. Typical dimensions and electricity output, Schlaich(2005)
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10797",leadTitle:null,fullTitle:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",reviewType:"peer-reviewed",abstract:"Cell culture is cell cloning technology that simulates in vivo environment conditions such as asepsis, appropriate temperature, and pH as well as certain nutritional conditions to enable cells to survive, grow, reproduce, and maintain their structure and function. Cell culture can be used to grow human, animal, plant, and microbial cells. Each type of cell culture has its own characteristics and essential conditions. This book focuses on the advanced technology and applications of cell culture in the research and practice of medical and life sciences. Chapters address such topics as primary cancer cell cultures, 2D and 3D cell cultures, stem cells, nanotechnology, and more.",isbn:"978-1-83969-446-2",printIsbn:"978-1-83969-445-5",pdfIsbn:"978-1-83969-447-9",doi:null,price:119,priceEur:129,priceUsd:155,slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",numberOfPages:154,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"2c628f4757f9639a4450728d839a7842",bookSignature:"Xianquan Zhan",publishedDate:"June 15th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",numberOfDownloads:834,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:null,numberOfDimensionsCitations:2,numberOfDimensionsCitationsByBook:null,hasAltmetrics:0,numberOfTotalCitations:3,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 4th 2021",dateEndSecondStepPublish:"March 4th 2021",dateEndThirdStepPublish:"May 3rd 2021",dateEndFourthStepPublish:"July 22nd 2021",dateEndFifthStepPublish:"September 20th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"9",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"47",title:"Cell Biology",slug:"biochemistry-genetics-and-molecular-biology-cell-biology"}],chapters:[{id:"78274",title:"A Brief Concept of Cell Culture: Challenges, Prospects and Applications",doi:"10.5772/intechopen.99387",slug:"a-brief-concept-of-cell-culture-challenges-prospects-and-applications",totalDownloads:203,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cell culture is an in vitro technique in which cells, tissues, or organs (animal origin) are artificially grown with the support of an artificial environment that encompasses culture medium, CO2 level, pH indicator, temperature keeping tissues alive and growing appropriately. Organ culture, Primary explant culture, and Cell culture among them cell culture widely used for the understanding of cell growth, normal functions, identification of growth factors, viral vaccine development, recombinant DNA (rDNA) technology, and immunobiological research. Due to high feasibility, cell culture practices highly demandable in the pharmaceutical industry. As well as animal cell culture used in laboratory research to study the cytotoxicity of new drug metabolic studies, aging, therapeutic proteins, the effects of drugs and toxic compounds on the cells and mutagenesis and carcinogenesis. There are a lot of issues in cell culture, Mycoplasma is one of the major. During cell culture, a single antibiotic often cannot kill the mycoplasma. Besides, culture media, pH indicator, incubation, cryopreservation, thawing, passaging of cells, and trypsinization have a great impact on cell culture. This chapter will help the reader to understand the whole process of cell culture and its applications, which will take them one step forward in their virology and cell culture research along with inspiration. This chapter also aids in the concept of cell count, cell suspension, CCF measurement, MOI (Multiplicity of Infection), and cell infection. Eventually, the reader will get a crystal clear concept of cell culture.",signatures:"Md. Salauddin",downloadPdfUrl:"/chapter/pdf-download/78274",previewPdfUrl:"/chapter/pdf-preview/78274",authors:[{id:"356004",title:"Dr.",name:"Md.",surname:"Salauddin",slug:"md.-salauddin",fullName:"Md. Salauddin"}],corrections:null},{id:"78377",title:"Overview of Primary Cell Culture Models in Preclinical Research of Prostate and Bladder Cancer",doi:"10.5772/intechopen.99493",slug:"overview-of-primary-cell-culture-models-in-preclinical-research-of-prostate-and-bladder-cancer",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The number of patients diagnosed with prostate and bladder cancer is increasing worldwide and one of the most important challenges remains the development of effective, safe and economically viable antitumor drugs. Clinical approval for drugs tested in preclinical studies enabling them to enter phase I clinical trials is essential. Cell lines are in vitro model systems that are widely used in different fields of medical research, especially basic cancer research and drug discovery. Their usefulness is primarily linked to their ability to provide an indefinite source of biological material for experimental purposes. Under the right conditions and with appropriate controls, authenticated cancer cell lines retain most of the genetic properties of the cancer of origin. Studies conducted during the initial development of drugs such as toxicity, corrosion and drug activity were carried out on animals; however, in the past two decades, alternatives have been sought due to the fact that animals do not effectively model to human in vivo conditions and unexpected responses are observed in the studies. Also, more than 100 million animals were used and billion dollars were spent for animal toxicity experiments. Cell culture studies made positive contributions to the initial development of drugs and is highly desirable, as it provides systems for ready, direct access and evaluation of tissues. Contrary to animal studies, less cost and the need for low drug and a short response time are the characteristics for in vitro cell culture methods. In vitro tumor models are a necessary tool, in not only the search for new substances showing antitumor activity but additionally for assessing their effectiveness. This chapter reviews the main features of primary cancer cell cultures, provides an overview of the different methods for their selection and management, and summarizes the wide range of studies that can be performed with them to improve the understanding of prostate and bladder cancer preclinical treatment processes.",signatures:"Kalyani Killekar, Sridevi I. Puranik, Aimen Akbar A., Shridhar C. Ghagane, Rajendra B. Nerli and Murigendra B. Hiremath",downloadPdfUrl:"/chapter/pdf-download/78377",previewPdfUrl:"/chapter/pdf-preview/78377",authors:[{id:"27304",title:"Dr.",name:"Murigendra B.",surname:"Hiremath",slug:"murigendra-b.-hiremath",fullName:"Murigendra B. Hiremath"},{id:"227286",title:"Dr.",name:"Shridhar C.",surname:"Ghagane",slug:"shridhar-c.-ghagane",fullName:"Shridhar C. Ghagane"},{id:"227446",title:"Prof.",name:"Rajendra B.",surname:"Nerli",slug:"rajendra-b.-nerli",fullName:"Rajendra B. Nerli"},{id:"328244",title:"Dr.",name:"Sridevi I.",surname:"Puranik",slug:"sridevi-i.-puranik",fullName:"Sridevi I. Puranik"},{id:"353768",title:"Mrs.",name:"Kalyani",surname:"Killekar",slug:"kalyani-killekar",fullName:"Kalyani Killekar"},{id:"419378",title:"Ms.",name:"Aimen",surname:"Akbar",slug:"aimen-akbar",fullName:"Aimen Akbar"}],corrections:null},{id:"78960",title:"Two-Dimensional and Three-Dimensional Cell Culture and Their Applications",doi:"10.5772/intechopen.100382",slug:"two-dimensional-and-three-dimensional-cell-culture-and-their-applications",totalDownloads:296,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cell culture is one of the most important and commonly used in vitro tools to comprehend various aspects of cells or tissues of a living body such as cell biology, tissue morphology, mechanism of diseases, cell signaling, drug action, cancer research and also finds its great importance in preclinical trials of various drugs. There are two major types of cell cultures that are most commonly used- two-dimensional (2D) and three-dimensional culture (3D). The former has been used since the 1900s, owing to its simplicity and low-cost maintenance as it forms a monolayer, while the latter being the advanced version and currently most worked upon. This chapter intends to provide the true meaning and significance to both cultures. It starts by making a clear distinction between the two and proceeds further to discuss their different applications in vitro. The significance of 2D culture is projected through different assays and therapeutic treatment to understand cell motility and treatment of diseases, whereas 3D culture includes different models and spheroid structures consisting of multiple layers of cells, and puts a light on its use in drug discovery and development. The chapter is concluded with a detailed account of the production of therapeutic proteins by the use of cells.",signatures:"Sangeeta Ballav, Ankita Jaywant Deshmukh, Shafina Siddiqui, Jyotirmoi Aich and Soumya Basu",downloadPdfUrl:"/chapter/pdf-download/78960",previewPdfUrl:"/chapter/pdf-preview/78960",authors:[{id:"349288",title:"Prof.",name:"Soumya",surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu"},{id:"418340",title:"Dr.",name:"Jyotirmoi",surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich"},{id:"429146",title:"Ms.",name:"Sangeeta",surname:"Ballav",slug:"sangeeta-ballav",fullName:"Sangeeta Ballav"},{id:"429147",title:"Ms.",name:"Ankita",surname:"Jaywant Deshmukh",slug:"ankita-jaywant-deshmukh",fullName:"Ankita Jaywant Deshmukh"},{id:"429148",title:"Ms.",name:"Shafina",surname:"Siddiqui",slug:"shafina-siddiqui",fullName:"Shafina Siddiqui"}],corrections:null},{id:"79031",title:"Isolation and Expansion of Mesenchymal Stem/Stromal Cells, Functional Assays and Long-Term Culture Associated Alterations of Cellular Properties",doi:"10.5772/intechopen.100286",slug:"isolation-and-expansion-of-mesenchymal-stem-stromal-cells-functional-assays-and-long-term-culture-as",totalDownloads:84,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Mesenchymal stem cell/stromal cells (MSCs) can differentiate into a variety of cell types, including osteocytes, adipocytes and chondrocytes. MSCs are present in the multiple types of adult tissue, such as bone marrow, adipose tissue, and various neonatal birth-associated tissues. Given their self-renewal and differentiation potential, immunomodulatory and paracrine properties, and lacking major histocompatibility complex (MHC) class II molecules, MSCs have attracted much attention for stem cell-based translational medicine research. Due to a very low frequency in different types of tissue, MSCs can be isolated and expanded in vitro to derive sufficient cell numbers prior to the clinical applications. In this chapter, the methodology to obtain primary bone marrow-derived MSCs as well as their in vitro culture expansion will be described. To assess the functional properties, differentiation assays, including osteogenesis, chondrogenesis and adipogenesis, 3-D culture of MSCs and co-culture of MSCs and tumor cells are also provided. Finally, the long-term culture associated alterations of MSCs, such as replicative senescence and spontaneous transformation, will be discussed for better understanding of the use of MSCs at the early stages for safe and effective cell-based therapy.",signatures:"Chenghai Li",downloadPdfUrl:"/chapter/pdf-download/79031",previewPdfUrl:"/chapter/pdf-preview/79031",authors:[{id:"425942",title:"Ph.D.",name:"Chenghai",surname:"Li",slug:"chenghai-li",fullName:"Chenghai Li"}],corrections:null},{id:"80484",title:"The Use of Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) to Study Ivermectin-Mediated Molecular Pathway Changes in Human Ovarian Cancer Cells",doi:"10.5772/intechopen.102092",slug:"the-use-of-stable-isotope-labeling-with-amino-acids-in-cell-culture-silac-to-study-ivermectin-mediat",totalDownloads:101,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Stable isotope labeling with amino acids in cell culture (SILAC) was to use isotopic essential amino acids to replace the original amino acids for cell culture and passage for 8–10 generations, followed by mass spectrometry to identify proteins and the isotopic abundance difference to quantify proteins. SILAC can be used to characterize proteomic changes, and analyze protein turnover, protein interactions, and dynamic changes with quantitative accuracy, and high reproducibility. For this study, SILAC “light” (L-Lysine-2HCl [12C6, 14N2], L-Arginine-HCl [12C6, 14N4])- or “heavy” (L-Lysine-2HCl [13C6, 15N2], L-Arginine-HCl [13C6, 15N4])-labeling RPMI 1640 medium was used to culture human ovarian cancer TOV-21G cells for 10 passages, followed by the treatment of 0.1% dimethylsulfoxide for 24 h and 20 µM ivermectin for 24 h, respectively. The light- and heavy-isotope-labeled proteins were equally mixed (1:1) for digestion with trypsin. The tryptic peptide mixture was fractionated with liquid chromatography and analyzed with tandem mass spectrometry. In total, 4,447 proteins were identified in ivermectin-treated TOV-21G cells in relation to controls. Those proteins were enriched in 89 statistically significant signaling pathways and 62 statistically significant biological processes. These findings clearly demonstrated that SILAC quantitative proteomics was a useful and reliable method to study ivermectin-related proteomic changes in cancer cells, which in combination with molecular pathway networks and biological processes enrichments provided more comprehensive insights into molecular mechanisms of ivermectin in inhibiting TOV-21G cells.",signatures:"Na Li and Xianquan Zhan",downloadPdfUrl:"/chapter/pdf-download/80484",previewPdfUrl:"/chapter/pdf-preview/80484",authors:[{id:"268659",title:"Ms.",name:"Xianquan",surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan"},{id:"468559",title:"Dr.",name:"Na",surname:"Li",slug:"na-li",fullName:"Na Li"}],corrections:null},{id:"78812",title:"Nanotechnology Application and Intellectual Property Right Prospects of Mammalian Cell Culture",doi:"10.5772/intechopen.99146",slug:"nanotechnology-application-and-intellectual-property-right-prospects-of-mammalian-cell-culture",totalDownloads:147,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:"The significant challenges faced by modern-day medicine include designing a target-specific drug delivery system with a controlled release mechanism, having the potential to avoid opsonization and reduce bio-toxicity. Nanoparticles are materials with nanoscale dimensions and maybe natural and synthetic in origin. Engineered nano-sized materials are playing an indispensable role in the field of nanomedicine and nanobiotechnology. Besides, engineered nano-sized particles impart therapeutic applications with enhanced specificity because of their unique bespoke properties. Moreover, such application-customized nanoparticles offer an enormous possibility for their compatibility with different biological molecules like proteins, genetic materials, cell membranes, and organelles at the nano-bio frame. Besides, surface functionalization with targeting moieties such as small molecule ligands, monoclonal antibodies, aptamers, cell-penetrating peptides, and proteins facilitate nanoparticle-based specific tissue targeting. This review summarizes some of the advances in nanoparticle-based therapeutics and theranostics. A better understanding of idealistic preparation methods, physicochemical attributes, surface functionalization, biocompatibility can empower the potential translation of nanomaterials from the ‘bench-to-bedside’. In modern-day medicine, engineered nanoparticles have a wide range of demands ranging from bio-imaging, theranostics, tissue engineering, sensors, drug and nucleic acid delivery, and other pharmaceuticals applications. 2D and 3D mammalian cell-based assays are widely used to model diseases, screening of drugs, drug discovery, and toxicity analyses. Recent advances in cell culture technology and associated progress in nanotechnology have enabled researchers to study a wide variety of physiologically relevant questions. This chapter explores the properties of nanoparticles, different targeted delivery methods, biological analysis, and theranostics. Moreover, this chapter also emphasizes biosafety and bioethics associated with mammalian cell culture and discusses the significance of intellectual property rights from an industrial and academic perspective.",signatures:"Harikrishnareddy Rachamalla, Anubhab Mukherjee and Manash K. Paul",downloadPdfUrl:"/chapter/pdf-download/78812",previewPdfUrl:"/chapter/pdf-preview/78812",authors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"9114",title:"New Developments in Large Scale Solar Energy Conversion",doi:"10.5772/7587",slug:"new-developments-in-large-scale-solar-energy-conversion",body:'\n\t\t
This chapter is dedicated to large scale electrical energy production from Solar energy. The scale considered here is that comparable with the output of conventional Thermal and Nuclear power plants, i.e. of the order of 50-1000 MW. The technology involved in such applications is generally significantly different than that encountered in low temperature, low capacity systems, such as domestic solar water heaters and charging of small appliance batteries.
\n\t\t\tIt is an established fact that fossil fuels are not replaceable and are being depleted at an alarming rate; moreover their direct burning produces atmospheric pollutants and CO2 which contribute to global warming. Nuclear energy may be a short term replacement for fossil fuels, however, nuclear fuel sources are also limited and problems with long term, safe and economic disposal of nuclear waste have not yet been solved. Thus many studies have indicated that solar energy is expected to be the prime source of energy fifty years from now. As early as 2025, it is projected that 10.7 % of total electrical energy production in the US would come from Solar energy sources alone, and that figure would rise to 69% by 2050, (Pernick and Wilder,2008); this is substantial energy capacity, considering that the US is the largest energy consumer in the world. The future forecast is that the cost of electricity generation from fuels such as coal, oil, natural gas, and even Nuclear energy will continue to rise, while solar technologies’ cost will continue to decline. Already, solar power can compete in regions with high electricity rates and with favourable incentives. Most countries of the developed world and many of the developing ones, are currently promoting the use of renewable energy by introducing incentives and legislation; these policies are expected to accelerate the wide spread of renewable energy sources in the near future.
\n\t\t\tSolar energy is one of the most abundant sources of renewable energy. The incident solar energy on the Earth’s surface is several orders of magnitude above current energy consumption. However the problem is the relatively low energy concentration, which is not an issue with low temperature applications such as solar water heaters, but poses a challenge to large scale or high temperature applications.
\n\t\t\tThe present chapter will start by reviewing the technologies currently available or proposed for large scale solar energy generation; these can be broadly divided into concentrating and non-concentrating technologies. It will start by reviewing the former type then focus on a new application of the latter type, namely the solar updraft tower, for which the author believes there is a bright future in desert environments.
\n\t\tConcentrating solar power (CSP) systems first concentrate the sun’s energy using reflective devices, then the resulting concentrated heat energy is transformed to a heat transfer medium, which is employed to power a conventional turbine to produce electricity. Concentrating systems make use of the direct radiation component only, and cannot benefit from the diffuse component of solar radiation. There are three main types of CSP systems: the parabolic trough system, the Heliostat solar tower system and the solar dish system. The first of these is a line concentrating system, whereas the latter two are point concentrating ones. Each type is now presented in turn.
\n\t\t\tTrough technology, is the simplest of the three concentration technologies and currently the most widely spread and developed(La Porta,2005). An example of such a system is the EuroTrough parabolic trough collector ( Michael et al., 2002). It basically consists of rows of cylindrical parabolic mirrors which collect solar radiation and focus it on a line, along which lies an absorber tube. A carrier fluid then flows within the tube receiving the heat and delivering it to the remainder of the cycle. A schematic of a solar electric generating system (SEGS) employing synthetic oil as heat transfer medium is displayed in Figure 1. The diagram also reveals a secondary oil heater cycle to operate the plant when solar radiation is inadequate, e.g. night time. Many existing SEGS plants display this dual mode feature.
\n\t\t\t\tLayout of a typical SEGS power plant, employing oil, (SOLEL, 2007)
The Californian company LUZ has built the largest solar energy generating system to date, boasting nine plants totalling 354 MW on a pure commercial basis, in the Mojave Desert, California. A picture of the parabolic trough collectors employed in this plant is displayed in Figure 2.
\n\t\t\t\tSEGS plant in Mojave Desert, California, Solel(2007)
The collectors of the Parabolic trough plants use a computerized single-axis solar tracking system, that tracks the sun from sunrise to sunset(Solel,2007). Typical collector mirrors are formed of a glass layer covered on the back by a silver layer which is protected against oxidation by suitable resins; a 30 year operational lifetime is envisaged. The reflectivity of the mirrors is around 94% and their concentration ratios are typically 82 times to yield operation temperatures of about 400 0C. The absorbing tube is usually made of steel and covered by a highly selective metallic oxide-ceramic layer displaying an absorptivity of approximately 97%. To reduce losses, the absorbing tube is covered by a vacuum glass tube with a transmissivity of approximately 95%. Synthetic oil is a common working fluid (heat transfer medium); although some recent projects have used water for direct steam generation in order to reduce cost and improve operating performance, albeit introducing problems of controlling the two phase flow in horizontal tubes. A solar collector assembly based on the EuorTrough design, operating year round at a site with a 2300 kWh/m2 annual direct radiation displayed a performance of 60% annual thermal collection efficiency, i.e. produced 1300 kWh thermal energy per year.
\n\t\t\t\tA modification of the parabolic trough system is the Fresnel trough system in which parabolic troughs are replaced by segmented mirrors operating according to the principle of Fresnel, Fig.3. The Belgium company Solarmundo operates a 2500 m2 prototype in Liège, Belgium. The mirrors have a typical width of 0.5 m and are either perfectly flat or display a very small curvature achieved by mechanical bending. The collector comprises 48 rows of mirrors, resulting in a collector width of 24 m. On top of the absorber tube is a second stage cavity reflector designed to re-direct some of the reflected rays to the top of the absorber tube, thus enlarging the target for the Fresnel mirrors, and producing a more uniform heating of the tube over its cross-section. It also serves to reduce heat losses from the selectively coated absorber tube.
\n\t\t\t\tFresnel collector principle (
Fresnel mirrors, absorber tube and secondary reflector(
\n\t\t\t\t\tFigure 4 shows a picture of such a system with the secondary reflector and absorber tube glowing brightly at the top of the frame, and the planar mirrors appearing at the bottom of the frame.
\n\t\t\t\tCompared to trough collectors, Fresnel collectors are slightly less efficient however the planar mirrors are much cheaper to manufacture and maintain, the tracking system is simpler and wind loads are considerably reduced. These advantages are expected to lead to a 50% reduction in cost over a comparable parabolic trough system(la Porta,2005).
\n\t\t\t\tMoreover, auxiliary benefits of this system have been suggested, among which are the use of the reflectors to act as a cover(roof) for large open car parks and exhibitions, and for a controlled greenhouse making use of the diffuse light and the light reflected from the back of mirrors. At the university of New South Wales, Australia, a model was developed in which more than one absorber line was employed and alternate mirrors pointed in alternate directions in such a way as to reduce shading between adjacent mirror lines.
\n\t\t\tIn this system an array of ground mirrors, called heliostats, reflect the solar radiation on to a target at the top of a tall central tower, as can be seen from Figure 5. This target is the receiver for the system while the heliostats are the collectors. The height of tower is determined by technical and economic optimization. Higher towers allow bigger and denser heliostat fields with lower shading losses. However, this is counteracted by need for higher tracking precision, and increased tower and piping construction costs, as well as pumping and heat losses. Common tower are 80-100 m tall, and are manufactured from either concrete or lattice structures.
\n\t\t\t\tThe 11 MW PS10 Solar Tower near Seville in Spain.
The heliostat field is composed of many single mirror facets, which are fixed on a steel structure and directed towards a focal point at the top of the tower, with the aid of a central processor. Each mirror has two degrees of freedom, rotating over both a horizontal and vertical axis, to closely track the sun’s motion. Some new heliostats are manufactured from thin metallic membranes or plastic foils, which are tightened on a metallic frame and shaped into parabolic concave form, thus improving the accuracy of projection on the focal point. They are also cheaper to manufacture than conventional glass mirror heliostats but are less resistant to wind and sand erosion and more difficult to clean and maintain.
\n\t\t\t\tCompared to parabolic troughs, central tower systems are less efficient in using ground space, since a larger surface area is required to avoid single heliostats shadowing each other. The shape of the heliostat array is dictated by the receiver type; for example a symmetric, field covering the full 3600 would be employed with an external receiver covering the entire periphery of the tower, while only a segment of this circle would be employed for a plain surface receiver, Figure 5. Four different types of receivers at the top of the tower have been tested so far; they are:
\n\t\t\t\tCavity receiver
this is a chamber tube receiver in which the heat transfer medium flows into the chamber inner walls, inside tubes which are bent into spirals and connected in parallel. The opening has a little surface which can be closed when direct solar radiation is poor. They are suitable for temperatures up to 6000C.
external receiver
this is made of external heat transfer panels composed of many heat transfer tubes. A major problem is the freezing of the heat transfer medium( e.g. molten salts or sodium) when solar heating drops. Evacuation of tubes under such conditions becomes a necessity.
volumetric receiver
this type is used for higher temperatures. Concentrated solar radiation is incident on a volumetric absorber material consisting of steel wire or porous ceramics, displaying a large surface contact area for heat exchange. In open volumetric receivers, ambient air is sucked in by a blower and penetrates the radiated absorber material; the receiver operating essentially at atmospheric pressure. Alternatively, closed air receivers are pressurized up to 15 bars; this made possible by closing the aperture with a fused quartz window. The absorber is composed of several layers of porous material, which are heated by the oncoming radiation. Wire meshing of high-temperature resistant metal wire is used up to temperatures of 800 0C, while high-porosity ceramic foams are used at higher temperatures. Due to the penetration of radiation waves, a highly uniform internal temperature distribution is achieved.
direct-absorption receiver
here heat transfer is carried out by thin fluid films or by little particles which stream in an air-flow. These receivers are still in the experimental stages, but should be able to achieve peak temperatures of 20000C and heat densities of 2000 kW/m2 ( La Porta,2005).
Heat transfer mediums which are commonly employed include water/steam, salt metals, liquid sodium and air; whereas a mixture of solid particles and gas for direct radiation absorption is currently undergoing investigation.
\n\t\t\t\tAmong new developments of the solar power tower is the introduction of beam-down optics in the Weizman Institute in Israel. In this a 70 m2 hyperboloidal reflector is installed up the tower with its upper focus coinciding with the heliostat field’s target point. The reflector redirects the solar radiation from the heliostat field towards the lower focus of the hyperboloid, located near ground. Secondary concentrating non-imaging devices and receivers are installed below the lower focal point; magnification of the sun image by the hyperboloidal mirror is compensated by the ground secondary concentrator with a considerable net gain in concentration. Moreover, the placement of receivers and power block on the ground simplifies operation and reduces cost. Recent developments in non-imaging optics have yielded concentrations unheard off before, reaching 84,000 x ambient intensity of sunlight! Other developments include high-performance air receivers and solar-to-gas turbine interface (Solarpaces,2001).
\n\t\t\tAs the name implies, the collector in this case is a parabolic shaped dish which concentrates the solar radiation on a receiver at its focal point. Two systems may be identified:
i) Dish-Stirling systems: a Stirling motor coupled to a generator is placed at the receiver end. In such systems the mirror, receiver, and motor-generator unit are rigidly connected and track the sun as one unit, Figure 6. ii) Dish-farm systems: Here a water/steam media flows through many dish-collectors collecting heat as it flows. The generated steam is then employed in a separate conventional Rankine cycle to generate electricity.A Dish – Stirling system, (
Dish-Stirling systems are relatively small power generation sets of typical capacities 5 -50 kW per unit; they are ideal for stand alone or other decentralized applications. However they may be connected in clusters with a capacity of 10 MW to meet moderate scale grid-generation demands. The solar radiation is absorbed by the receiver heat exchanger to heat the working fluid(helium or hydrogen) of the Stirling engine to temperatures of about 6500C (Schelich Bergermann und Partner,2002). The engine is connected to a generator to produce electricity. The concentrator is mounted on a two-axis tracking system which tracks the sun continuously with the aid of servo-motors. The signal to the motor comes from either an instantaneous sun tracking sensor or from computer software which predicts the sun position.
\n\t\t\t\tThe Sterling engine is ideally suited for the Dish-parabolic system. Not only does it follow the most efficient thermodynamic cycle, but it also employs an external heat source which allows it to operate with a hybrid heat receiver. Thus with an additionally installed burner, the heat source could be either the solar radiation or any other combustible fuel (e.g. bio-gas or natural gas) thus extending operation to cloudy periods and night time hours. Coupled with a digester producing bio-gas, the hybrid operated system could produce continuous electric output from renewable and environmentally friendly sources.
\n\t\t\t\tSince there is no internal combustion, combustion roar(noise) is absent and the “potential life-cycle of a Stirling engine is extraordinary high” (Schelich Bergermann und Partner,2002). Research is currently ongoing(Abdel-Rahman and Serag-Eldin,2008) to replace the Stirling engine with a corresponding Thermo-acoustic engine (Swift,2002) which features much of the advantages of the Stirling engine in addition to possessing no moving parts.
\n\t\t\tSolar updraft towers are non-concentrating solar energy plants designed for very large scale energy conversion, of the order of 200 MW; the larger the better. Because of lack of solar radiation concentration, the working fluid temperature rise within the plant is among the lowest in all large scale energy applications, and their conversion Carnot efficiencies are consequently very low. However, they compensate for their lower efficiencies with relatively low construction costs per kWh of electricity generated. Moreover, they possess several advantages which make them ideally suited for desert environments.
\n\t\t\tThe original name for Solar Updraft towers was Solar Chimney Power plants; however due to the connotation with polluting chimneys, the name quickly fell out of favor and was replaced with the current one. As the original name signifies, the heart of the solar plant is a tall chimney stack, which is surrounded by a large conical collector, Figure 7. Pressure staged wind turbine-generator unit(s) extract the energy in the chimney draft to produce electrical power; their loation indicated by W.T. in Figure 7.
\n\t\t\tSketch of a Solar Updraft tower (Solar Chimney)
Solar updraft tower power plants are renewable energy devices which generate electrical power from solar energy after first converting it into wind (kinetic) energy. They comprise three main components, a central tall chimney stack (tower), a surrounding solar radiation collector, and turbine unit(s).
\n\t\t\t\tThe collector comprises an elevated glass ceiling, covering a large area of ground acting as an absorber. The ground may also be partially covered with water tubes or shallow containers to improve its thermal storage properties. Solar radiation penetrates the collector ceiling to raise the temperature of the collector floor(ground), by virtue of the well known “green-house effect”. The latter warms the air flowing immediately above it; and the hot air being lighter than the surrounding atmospheric air, rises up the chimney stack driven by buoyancy forces. This upward chimney draft is used to drive pressure-staged wind turbines. It also creates a partial vacuum at the bottom of the stack, which continuously sucks in fresh atmospheric air from the outer edges of the collector, and overcomes the internal flow resistance as the air flows inwards towards the stack, Figure 8.
\n\t\t\t\tTheory of operation of Solar Updraft tower
The Solar collector and stack cross-section are usually perfectly circular; thus the flow within the solar collector and chimney may generally be assumed to be axially symmetric. Indeed, if only conceptual design is required, the flow variations in the cross stream direction may be neglected and quasi-one dimensional models may be employed, e.g. Padki and Sherif(1999), Von Backstrom and Gannon(2000) and Pasumarthi and Sherif(1997). More detailed CFD models employing turbulence modeling and considering flow and property variations in all directions (Serag-Eldin,M.A. 2004a, b\n\t\t\t\t\t2005a) are required for detailed geometric design and accurate performance calculations.
\n\t\t\tIn 1931, Hanns Gunther presented one of the earliest descriptions of a solar chimney power plant. As early as 1975, Robert Lucie applied for patents on a solar chimney electric power generator(Wikipedia,2007), yet to date there is not yet a single full scale commercial application. The cause is simple to explain; economically viable updraft towers need to be very large units, costing around $700 million, and potential investors are simply reluctant to risk this outlay on a technology which has not been field tested. However several starts have been made which are reported next.
\n\t\t\t\tIn the late 1970’s and early 1980’s Professor Jorg Schlaich and his team at Schlaich Bergermann und Partner of Stuttgart, Germany developed a detailed proposal for a solar updraft tower, eventually gaining funding from the German Federal Ministry of Research and Technology to build an experimental pilot plant in Manzanares, Spain., Figure 9. The tower was 195 m tall and 10 m in diameter, with a collection area of 46000 m2 ( approx. 244 m diameter) producing a maximum output of 50 kW. The mean roof height was 1.85 m, and it possessed a single 4-blade axial turbine with a blade tip speed ratio of 10. The typical air temperature rise over ambient was 17 K. The majority of the collector was covered with plastic membranes(40000 m2) and the rest covered with glass(6000 m2). Vertical wind velocity in the stack reached a maximum of 12 m/s during turbine operations (Schlaich,2005).
\n\t\t\t\tPicture of the 50 kW Solar Chimney plant at Manzanares, Spain.
The plant was highly instrumented with more than 180 sensors to record system behavior every second. It operated from 1982–1989, almost continuously with an availability exceeding 95%, until it was finally decommissioned due to structural problems. Plastic membrane covers were found cheaper than glass covers; however comparison between glass and plastic membrane endurance showed that glass resisted heavy storms for many years without harm and proved to be self-cleaning with occasional rains; whereas plastic membranes got brittle with time and tended to tear.
\n\t\t\t\tIn 2000, the Australian company EnviroMission Ltd was founded, and became the exclusive holder of the Australian license to Solar Tower Technology (Thomas and Davey,2004). The following year it unveiled a plan to build 200 MW solar updraft tower plants at a cost of approximately $700 million/plant, the first plant to commence construction in 2006, at Burronga Station, in the Riverland area of New South Wales. The stack height would be 1000 m tall and 120 m in diameter, whereas the collector diameter would be about 7000 m. Additional thermal storage would cover 25% of the total collector area and the plant was expected to operate 24 hrs. a day, at or close to nominal output in summer; albeit at significantly reduced output in winter. A total of 32 x 6.25 MW pressure-staged horizontal-axis turbines, symmetrically distributed on the ground close to the stack inlet would provide the necessary power. For large solar chimneys the air temperature in the collector is expected to be about 35 K, and the updraft velocity around 15 m/s.
\n\t\t\t\tHowever some time in 2006 the project was downscaled from 200 MWs to 50 MW (McLaren, 2006), because of the withdrawal of contractor and re-direction of some of the Australian government’s funding. The reduced output plant should feature a 480 m tall tower of 78 m diameter, encircled by a 3300 m diameter collector. The height of collector at inlet will be 2.4 m and it will gradually slope up to 15 m at the tower’s base. Unfortunately, the future of this project itself is still vague; the recent EnviroMission website states that “EnviroMission is now set to spearhead development and promotion of the Australian Solar Tower concept into markets outside Australia” and that “conditions in the USA support development ahead of Australia at this time”.
\n\t\t\t\tOutside Australia several countries have also shown interest in building Solar updraft towers at some stage or other. Among these is Sri-Lanka’s 200 MW project(Gluckman,2002), a 3x 200 MW project in the USA (Donovan,2004), the 200 MW plant in Rajasthan, India(2002) and a 200 MW plant in China (Woody,2006 ). A Spanish proposal for a 40 MW plant in Ciudad Real is also under consideration. In mid 2008 the Namibian government approved a proposal for the construction of a 400 MW solar chimney called the \'Greentower\'. The tower is planned to be 1.5 km tall and 280 m in diameter, and the base will consist of a 37 km2 greenhouse in which cash crops can be grown(Cloete,2008). It is difficult to know precisely the exact status of any of these projects right now, or how they will fare in the future; for up to date information it is recommended to visit the project’s website, if it still exists!
\n\t\t\tThe collector is basically a large green house. The cover is made from a transparent material such as glass which has high transmissivity for short wave solar radiation, and low transmissivity for reflected and emitted long wave radiation from the ground and surroundings. The net balance heats the ground of the collector, raising its temperature above that of the surroundings. The ground then warms the flowing air above it by forced convection. The collector uses all solar radiation, both direct and indirect; this is crucial for tropical countries where the sky is frequently overcast. The collector converts up to 70% of its irradiated solar energy into heat, a typical annual average being 50% (Schlaich,1995).
\n\t\t\t\tSolar radiation varies sharply throughout the day; however it is commonly assumed that the ground temperature does not vary appreciably due to its large thermal capacity. Moreover since air temperature rise is the main factor affecting plant performance, and not ground temperature, the effect of cooler ground temperatures during night time on plant performance is partially offset by cooler external air temperatures. In desert environments, the difference between peak air daytime temperature and lowest night time temperature often exceeds 20 K.
\n\t\t\t\tAlthough the typical soil material forming the ground of the collector has high thermal capacity, its thermal diffusivity is low (it’s also a good insulator) and thus the thermal penetration length during the day time hours is limited. Thus relatively large fluctuations in ground temperature would occur over the 24 hours, affecting uniformity of plant performance. Hence additional thermal storage is required in the form of shallow water cushions or tubes, which typically cover about 25% of the area of the collector foot print with an average depth of 5-20 cms. Although the thermal diffusivity of water is also low, its fluidity allows heat diffusion by natural convection which is orders of magnitude larger than molecular diffusion, thus increasing the effective thermal penetration depth. In the Manzanares test facility no additional thermal storage was added, and it was found that the output of the plant did vary appreciably throughout the day, confirming the need for additional thermal storage with high effective diffusivity.
\n\t\t\t\tThe collector cover is inclined upwards with a small slope as it approaches the chimney stack. This slope is required in order to maintain a relatively constant flow velocity within the collector as the radius, and therefore flow area, decreases; as well as to change the flow direction smoothly as it enters the stack. The height of the collector cover at inlet should be sufficiently high to allow easy access of personal and maintenance equipment, and to produce low air flow velocities underneath collector cover so as to reduce flow losses. However, it should not be too high as this would increase construction costs, as well as negatively affect plant performance in presence of strong external atmospheric winds(Serag-Eldin,2004b). A height of 2.4 m is usually specified.
\n\t\t\t\tThe results of the Manzanares test facility indicated that currently the preferred cover material is glass; however future material developments may lead to a superior and cheaper plastic membrane.
\n\t\t\t\tClose to the chimney stack, the temperature difference across the collector cover may exceed 30 K so that double glazing may be justified there, but not elsewhere. Near the inlet boundaries of the collector the air temperatures are favorable for plant growth, and this area may be exploited for growing or drying crop with negligible effect on performance, particularly since it is also the region with the minimum flow velocities. Indeed in Manzanares considerable wild plants were found to sprout underneath the collector cover, enjoying the green house effect.
\n\t\t\tThe chimney stack is the plant’s thermal engine. It is a pressure tube with low friction losses because of its very low surface/volume ratio. The efficiency of the Solar Chimney plant, is directly proportional to the height of the stack(Gannon and Backstrom,2000); thus the taller the stack the more efficient the cycle.
\n\t\t\t\tThe chimney for the Manzanares test facility was constructed from sheet metal for economy purposes; however, full scale plants are expected to employ reinforced concrete structures and are expected to be around 1000 m tall. The life span of a reinforced concrete tower in a dry climate is at least 100 years. All the structural technology is already available and tested in cooling towers and in building towers such as the 600 m tall television tower in Toronto, Canada. Alternatively, guy tubes, their skin made of corrugated metal sheet, cable-net with cladding or membranes are also possible.
\n\t\t\t\tThe chimney is likely to be the most expensive component of the solar plant, and hence it is important to try to cut its cost down. Among ideas to reduce chimney cost is one that proposes a “Floating Chimney” (Papageorgiou,2004). Floating solar chimneys are lighter than air structures that can be as tall as 1.5 – 3 km. The wall sub pressure, acting on the main body cylinder of the chimney is handled by the supporting rings made of aluminum, or air inflated pressure tubes. The lifting force comes from a set of toridal tubes filled with lighter than air gas, such as He or NH3. Similar ideas have been proposed by others, e.g. use of vacuumized toroidal rings instead of gaz filled ones (Hamza Associates, 2008). However, questions pose themselves regarding the reliability and life time of such structures, as well as the increased resistance to internal flow when the stack walls are deformed by strong shear winds.
\n\t\t\t\tIn an attempt to cut chimney stack costs considerably, it was proposed (Serag-eldin,2007) to search for special sites where favorably oriented steep mountains or cliffs may be found close to valleys, and thus the chimney stack would be replaced by a duct running up the mountain/cliff. Figure 10 displays such a geometry for a hypothetical case where the mountain on the right is inclined at 450 to a horizontal valley; the turbine(s) were distributed in a horizontal section at the bottle-neck displaying (W.T.). CFD simulation was employed to design the collector and updraft duct for this case as well as to predict plant performance. Notice the diverging duct cross-section in Figure 10 ; this recovers most of the kinetic energy head, thus raising cycle efficiencies. Also notice the shape of the collector which was developed to yield a smooth uniform velocity entry at the turbine. The latter is confirmed from Figure 11 which displays the velocity vectors in a horizontal section below the collector cover.
\n\t\t\t\tExploiting the height of a neighboring steep mountain(Serag-eldin,2007)
Velocity vectors in one half of the collector(Serag-eldin,2007)
The turbine(s) produce the mechanical output of the plant. They are pressure staged ones, considerably different than conventional wind-turbines, and more akin to Kaplan turbines employed in hydraulic power stations. Schematically, only a single turbine is always displayed, which is located a short distance up the chimney stack. This is probably for historical reasons, since it was the case for the 50 kW Manzanares plant, because it had relatively low output. However, because of the large dimensions of a full scale 100 – 200 MW plant, it is not possible nor practical to have a single axial turbine of such large diameter (of the order of 100 m).
\n\t\t\t\tThus full scale plants are expected to adopt one of two configurations:
\n\t\t\t\tseveral small vertical axis turbines covering the cross-section of the stack and at a small vertical distance from its base. They would however be independently supported on the ground to avoid structural loads on the stack and vibration problems. Figure 12 displays such an arrangement.
a ground level array of horizontal axis turbines positioned at equal spacing, along a circle of diameter slightly larger than stack’s diameter, as sketched in Figure 13\n\t\t\t\t\t\t
The 6 vertical axes turbines on a C.S. plane near base of stack(
The wind turbine characteristics have a strong bearing on the performance of a given solar chimney plant. For example, selecting a turbine with a lower specific-speed results in turbine characteristics with higher head across the turbine for a given flow rate. When this turbine is installed in a given solar plant installation, it will reduce the induced air flow rate because less head will be available to overcome system losses. However, since the power output from the turbine is proportional to the product of the head across the turbine times the volumetric flow rate, the net product may be either greater or lower than that of a higher specific-speed turbine, i.e. one displaying lower head across the system for a given flow rate.
\n\t\t\t\tMoreover, as the induced air flow rate through the system is decreased, the absorber temperature and air temperature will rise for a given solar intensity. The latter affects system heat losses and pressure head across the stack; both of which will affect the performance of the plant. Thus to obtain the maximum performance from a given solar chimney plant (maximum power output) it is necessary to select the optimum turbine characteristic for a given solar plant characteristics and operating conditions.
\n\t\t\t\tAs a rule of thumb, the output is maximized if the pressure drop across the turbine is approximately two thirds the total pressure differential available; however for accurate estimates it is necessary to solve the flow equations within the collector and stack coupled with the turbine pressure drop dictated by the turbine characteristics, retaining the full two way coupling between the turbine characteristic and the characteristics of the rest of the system. The results of such a study(Serag-Eldin, 2005b) is presented in Figure 14 which displays the computed variation of velocity in stack, Vstack, plant Output and exit stack temperature, Tstack, for a given system characteristic and solar radiation, and for 9 different turbine characteristics, each result corresponding to a different turbine characteristic. It is clear that the Output curve reveals a maxima, indicating that one of the characteristics is more suitable than others.
\n\t\t\t\tEffect of turbine characteristic on performance of plant(
Some researchers have proposed replacing the array of wind turbines with a circular track carrying carriages supporting individual vertical aerofoil blades of uniform cross-section, spanning the entire height of the collector. The cascade of aerofoil blades rotate as one unit around the chimney center line, producing the plant useful work(Valentine,2008). Independently, others (Menoufy and Serag-eldin,2009) have been designing a somewhat similar wind turbine system with the aerofoil blades replaced by cylinders rotating about their axis. The lift force in this case is derived by the Magnus effect, and can be easily controlled by regulating the cylinder rotational speed. Their system is expected to be much cheaper and easier to build and maintain than conventional propeller turbines.
\n\t\t\t\tTurbines inserted in Solar Updraft towers are not subject to gusts, high turbulence, highly fluctuating and non-uniform winds such as wind turbines, nor cavitations such as hydraulic turbines; hence their life span is expected to be longer than both.
\n\t\t\tA CFD computation of a typical solar updraft tower plant (Serag-Eldin,2005a) was conducted to investigate the effect of different geometric ratios on plant
\n\t\t\t\tperformance(Output), velocity in the stack, Vstack, and stack exit temperature, Tstack. The
\n\t\t\t\tresults showed minor influence of the geometric ratios, with the exception of the ratio of stack-height to collector-radius, Hstack/Rcollector, Figure 15. It was found that the output of the plant increased almost linearly with stack height, all other parameters remaining the same. Increase of stack height also increased Vstack and reduced Tstack.
\n\t\t\t\tEffect of stack height on plant performance(
Investigation of effect of plant size on the Output, Vstack and Tstack was then conducted, retaining same geometric ratios throughout, but increasing the individual dimensions to scale. The results are displayed in Figure 16 with the collector outer radius dimension representing the plant size. It was revealed that the increase in power output with size was at a rate slightly faster than the cube of the size. No wonder economically viable plants need to be of large capacity!
\n\t\t\t\tEffect of Plant size on performance(
The optimum geometric ratios of a solar updraft tower at a particular site will also depend largely on the relative cost of construction of the collector and chimney stack at this site. This cost may vary appreciably from one site to another; however, just as a global, rough guide, recommended dimensions are presented in Table 1.
\n\t\t\t\t\n\t\t\t\t\t\t\t\tCapacity MW 5 30 100 200 Tower height m 550 750 1000 1000 Tower diameter m 45 70 110 120 Collector diameter m 1250 2900 4300 7000 Electricity outputA GWh/a 14 99 320 680 A at a site with annual global solar radiation of 2300 kWh/(m2a) \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\tMW | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t30 | \n\t\t\t\t\t\t\t100 | \n\t\t\t\t\t\t\t200 | \n\t\t\t\t\t\t
Tower height | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t\t550 | \n\t\t\t\t\t\t\t750 | \n\t\t\t\t\t\t\t1000 | \n\t\t\t\t\t\t\t1000 | \n\t\t\t\t\t\t
Tower diameter | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t\t45 | \n\t\t\t\t\t\t\t70 | \n\t\t\t\t\t\t\t110 | \n\t\t\t\t\t\t\t120 | \n\t\t\t\t\t\t
Collector diameter | \n\t\t\t\t\t\t\tm | \n\t\t\t\t\t\t\t1250 | \n\t\t\t\t\t\t\t2900 | \n\t\t\t\t\t\t\t4300 | \n\t\t\t\t\t\t\t7000 | \n\t\t\t\t\t\t
Electricity output A\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\tGWh/a | \n\t\t\t\t\t\t\t14 | \n\t\t\t\t\t\t\t99 | \n\t\t\t\t\t\t\t320 | \n\t\t\t\t\t\t\t680 | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tA at a site with annual global solar radiation of 2300 kWh/(m 2 a) | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\tTable 1. Typical dimensions and electricity output, Schlaich(2005)
In absence of a track record, estimates of electricity generation costs from this technology vary widely; e.g. Schlaich et al(2005) estimate a cost of 7 – 21 € per kWh, while others (Zaslavsky,2006) believe it would be no cheaper than 25-36 cents per kWh. The following Table is thus useful mainly for comparing relative component costs and trends, and should be accepted with reservation:
\n\t\t\t\tCapacity | \n\t\t\t\t\t\t\tMW | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t30 | \n\t\t\t\t\t\t\t100 | \n\t\t\t\t\t\t\t200 | \n\t\t\t\t\t\t
Tower cost | \n\t\t\t\t\t\t\t( in million €) | \n\t\t\t\t\t\t\t19 | \n\t\t\t\t\t\t\t49 | \n\t\t\t\t\t\t\t156 | \n\t\t\t\t\t\t\t170 | \n\t\t\t\t\t\t
Collector cost A | \n\t\t\t\t\t\t\t( in million €) | \n\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t48 | \n\t\t\t\t\t\t\t107 | \n\t\t\t\t\t\t\t261 | \n\t\t\t\t\t\t
Turbine cost | \n\t\t\t\t\t\t\t( in million €) | \n\t\t\t\t\t\t\t8 | \n\t\t\t\t\t\t\t32 | \n\t\t\t\t\t\t\t75 | \n\t\t\t\t\t\t\t133 | \n\t\t\t\t\t\t
Engineering, tests, misc. | \n\t\t\t\t\t\t\t( in million €) | \n\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t16 | \n\t\t\t\t\t\t\t40 | \n\t\t\t\t\t\t\t42 | \n\t\t\t\t\t\t
total | \n\t\t\t\t\t\t\t( in million €) | \n\t\t\t\t\t\t\t42 | \n\t\t\t\t\t\t\t145 | \n\t\t\t\t\t\t\t378 | \n\t\t\t\t\t\t\t606 | \n\t\t\t\t\t\t
Annuity on investment | \n\t\t\t\t\t\t\t(million €/a) | \n\t\t\t\t\t\t\t2.7 | \n\t\t\t\t\t\t\t10.2 | \n\t\t\t\t\t\t\t27.1 | \n\t\t\t\t\t\t\t43.7 | \n\t\t\t\t\t\t
Annual operation & maintenance cost | \n\t\t\t\t\t\t\t(million €/a) | \n\t\t\t\t\t\t\t0.2 | \n\t\t\t\t\t\t\t0.6 | \n\t\t\t\t\t\t\t1.7 | \n\t\t\t\t\t\t\t2.8 | \n\t\t\t\t\t\t
Levelized elelectricity cost (LEC) B | \n\t\t\t\t\t\t\t(€/kWh) | \n\t\t\t\t\t\t\t0.21 | \n\t\t\t\t\t\t\t0.11 | \n\t\t\t\t\t\t\t0.09 | \n\t\t\t\t\t\t\t0.07 | \n\t\t\t\t\t\t
A cost for unskilled labor assumed 5 ?/h; B at an interest rate of 6 % and 30 yrs depreciation | \n\t\t\t\t\t\t
Investment cost and LEC, Schlaich et al (2005).
\n\t\t\t\t\tTable 2 reveals the rapid drop in LEC as plant size increases. It also reveals that the major cost is the tower cost, the only exception being for the 200 MW plant, since it employs the same tower height as the 100 MW plant but a much larger collector area. It is noticed that the source assumed a rate of 5 €/h for unskilled labor; however for many developing countries the cost is substantially lower, whereas the cost of constructing the tower and importing and installing the turbines may be higher, thus shifting the cost distribution.
\n\t\t\tSolar updraft towers possess the following strengths:
\n\t\t\t\t(a) make use of both direct and indirect solar radiation
(b) possess a large built in thermal storage in the form of the ground underneath the collector. Extending this with a thin layer of scattered water tubes or cushions enhances the ability of the plant to operate at almost constant output 24/7. Thus standalone operation is possible for remote areas not connected to a central electrical grid.
(c) do not need any cooling water to operate
(d) their simplicity makes them particularly reliable and hard wearing, and not prone to sudden shut down
(e) most of the plant is built on the desert site itself employing local labor; thus providing job opportunities in under-developed countries.
(f) requires very few personal to operate
(g) maintenance cost is minimal and should endure the harsh desert environment better than most other technologies.
However, solar updraft towers suffer the following weaknesses:
\n\t\t\t\t(a) very low efficiency means it requires a large area of land for collectors
(b) frequent desert storms coupled with long dry spells may reduce efficiency of collectors.
(c) plant may suffer from effect of exceptionally strong external winds, both at ground level and above(Serag-Eldin, 2004b).
(d) tall slender stack is particularly vulnerable to Seismic actions; hence conventional rigid stacks may not be suitable for regions displaying strong seismic activity.
(e) very tall towers may impose construction challenges.
The upper limit for the conversion-efficiency of solar-energy into mechanical-energy by all the solar-power-systems, is restricted by Carnot’s efficiency, ηc, defined by
\n\t\t\twhere Tsource and Tsink refer to the heat source and sink temperatures, respectively. Carnot’s efficiency is only a theoretical maximum. In practice, attainable efficiencies are always considerably less due to system losses and irreversibility effects; however Carnot’s efficiency serves to indicate the maximum potential of each system and to give an indication of the relative true efficiencies of real systems. In our applications the heat source temperature is the maximum temperature in the cycle, which is the temperature at the receiver end of CSP systems, and the temperature at the exit from the collector and inlet to stack in the solar updraft tower system. The heat sink temperature is invariably the atmospheric temperature.
\n\t\t\tTherefore it is clear that systems which produce highest concentration of solar energy, and therefore highest heat source temperatures, are the most efficient in converting solar energy into mechanical energy, and vice versa. Table 3 summarizes the typical source temperatures, concentration ratios, C, tracking system type and ηc, for each of the systems presented earlier. The concentration ratio is defined as the ratio between the optically active surface of the collector and the irradiated absorber’s surface.
\n\t\t\tTechnology | \n\t\t\t\t\t\tT source ( o C) | \n\t\t\t\t\t\tC | \n\t\t\t\t\t\tTracking | \n\t\t\t\t\t\tηc | \n\t\t\t\t\t
Solar updraft tower | \n\t\t\t\t\t\t20 - 8 0 | \n\t\t\t\t\t\t1 | \n\t\t\t\t\t\t- | \n\t\t\t\t\t\t1 7 % | \n\t\t\t\t\t
Parabolic trough | \n\t\t\t\t\t\t260-400 | \n\t\t\t\t\t\t8-80 | \n\t\t\t\t\t\tOne axis | \n\t\t\t\t\t\t56% | \n\t\t\t\t\t
Fresnel reflector | \n\t\t\t\t\t\t260-400 | \n\t\t\t\t\t\t8-80 | \n\t\t\t\t\t\tOne axis | \n\t\t\t\t\t\t56% | \n\t\t\t\t\t
Heliostat field w/central receiver | \n\t\t\t\t\t\t500-800 | \n\t\t\t\t\t\t600-1000 | \n\t\t\t\t\t\tTwo-axis | \n\t\t\t\t\t\t73% | \n\t\t\t\t\t
Dish concentrators | \n\t\t\t\t\t\t500-1200 | \n\t\t\t\t\t\t800-8000 | \n\t\t\t\t\t\tTwo-axis | \n\t\t\t\t\t\t80% | \n\t\t\t\t\t
Typical Source temperatures, concentration ratios and ηc for solar systems
It is apparent that the solar updraft tower has the least conversion efficiency because it does not provide any concentration what-so-ever; however it is also the simplest system because it does not need any tracking system. The Heliostat and Dish concentrator systems have the highest Carnot efficiencies, but are also the most complicated since they require to track the sun continuously in two planes(2-axis tracking). Fresnel and trough systems require tracking in only one direction and hence both their complication levels and efficiencies lie between the other two categories.
\n\t\t\tHowever, since solar energy is free and abundant, efficiency should not be used as the basis for selecting a system. Its impact should be confined to its role in reducing the total cost of solar energy conversion. Thus a less efficient but cheaper system may be the logical choice if its total cost of production of 1 kWh of electricity is lower. The cost of kWh is usually the prime criterion for selection of a system, but other important criteria include environmental impact, sustainability, reliability, durability, ease of maintenance, social returns, creation of local job opportunities, technology transfer, national energy strategy, and whatever other benefits or costs to the society that may result from the particular technology selected.
\n\t\tThe review serves to demonstrate that solar energy technologies in the power sector are developing rapidly in several fronts, all of which strive to reduce the cost of energy conversion. This, together with economy of scale when solar energy technologies have spread widely, should pave the way for solar energy plants to gradually replace conventional and nuclear plants whose technologies have already matured so that further improvements are limited, and whose total construction and running costs are escalating.
\n\t\t\tOne major difference between conventional and renewable energy technologies in general and solar in particular, is that the latter are very site specific, whereas the former are not. Thus a desert site may be ideal for a particular type of solar energy technology and totally unsuitable for another. Also the degree of sophistication required to operate and maintain some types of solar technologies is much higher than others, and some technologies are only suited to very large scale applications while others are not; some have built in thermal storage while others require external storage; some are more suitable for standalone mode than others. For each solar energy application we have several options, but it makes a very big difference to the success of the project that the most appropriate technology is the one selected for the given site and environment.
\n\t\t\tCurrently parabolic trough-collectors are the most commonly used and are already cost effective in many parts of the world; the Fresnel mirror adaptation may further cut their conversion costs. However it is the Heliostat towers that are attracting most attention with their promise to yield very high concentrations with the beam-down optics, and ground steam generation.
\n\t\t\tThe solar updraft tower is, at least on paper, a very viable candidate for the desert environment. However it is severely handicapped by the need to start big(minimum 200 MB), costing at least $700 million to be viable. Several projects have started but have either slowed down or stalled. A new project approved in Namibia in mid 2008 to build the largest ever contemplated solar updraft tower (400 MB) will hopefully see the light of day. If this project is implemented and succeeds, the solar updraft tower may turn out to be the black horse for desert environments. Furthermore, for certain favorable sites, the stack cost may be reduced considerably by following one of the suggestions presented here, so that the plant may be viable for plant sizes as small as 50-100 MB.
\n\t\t\tFinally, when comparing between Solar and conventional energy for electricity generation, it is prudent not to base the decision based on the cost of the kWh produced alone, but to include other important factors such as environmental impact, sustainability, reliability and social benefits.
\n\t\tCalcium phosphate cements (CPCs) were proposed by Brown and Chow [1] and LeGeros et al. [2] in the 1980s. In 1990, the first CPC was used commercially in the treatment of maxillofacial defects and fractures [3, 4, 5].
CPCs consist of a combination of one or more calcium orthophosphate powders in which a liquid phase, usually water or an aqueous solution, is added, allowing it to be set and hardened at the site of the body where it was implanted. This type of cement hardens through a dissolution reaction and a precipitation process, distinguishing itself from other cements that harden through a polymerization reaction. Over time, new compositions have been synthesized promoting specific characteristics to the cements for various applications such as bone augmentation and strengthening [6, 7, 8, 9, 10, 11, 12, 13, 14], fixation of metal implants [15, 16], and vertebral fractures [17, 18, 19].
The CPCs have the essential advantage of hardening in vivo through a low-temperature reaction. After mixing, the material becomes moldable, and its noninvasive injection represents an important advantage over conventional calcium phosphate ceramics. The fact that this type of cement does not present an exothermic reaction also makes it able to incorporate different drugs and other biological molecules, allowing its application in treatments by drug delivery [20]. In addition to the aforementioned advantages, CPCs have excellent bioactivity and osteoconductivity and an excellent ability to form a bone bond. Its rate of resorption is also a factor to take into account, since, after modifying its structure, it is possible to modify that rate. Calcium phosphate cements also have disadvantages, namely, their low mechanical performance, which limits their application in bearing situations. Its intrinsic porosity also leads to this material presenting less strength compared to calcium phosphate ceramics [21, 22].
The cements tend to dissolve in order to achieve a stable and less soluble phase, the dissolution being controlled by the pH of the medium. The cements based on hydroxyapatite or brushite are the only final reaction products because they are the most stable at pH > 4.2 and pH < 4.2, respectively, even though there are a large number of formulations. In addition, and because these materials are intended to be used as bone substitutes, it is important to take into account that the values of the compressive strength of the cortical bone vary between 90 and 209 MPa, [23, 24] and the spongy bone varies between 1.5 and 45 MPa. [25]. As reference values, the compressive strength of apatite cements usually ranges from 20 to 50 MPa [26, 27, 28, 29, 30, 31, 32]. Brushite CPCs are generally weaker than apatite CPCs being around 25 MPa [33].
In summary, the main characteristics of this type of cement are presented in Table 1.
Calcium phosphate properties | |
---|---|
Material type | Ceramic |
Liquid phase | Water or aqueous solutions |
Powder component | Calcium phosphate powders |
Setting reaction mechanism | Dissolutions and precipitation reaction |
Reaction products | Calcium phosphates, usually hydroxyapatite or brushite (37°C) |
Stability | Resorbable (low or high resorption rate depending on composition and microstructure) |
Bioactivity | Bioactive |
Applications | Bone regeneration; non-load-bearing applications |
The nature and properties of calcium phosphate bone cements (adapted from [34]).
The mechanical properties are the main properties to take into account when developing a biomaterial to apply surgically. The microstructural characteristics (porosity, quantity, size, morphology, and distribution of the crystals formed) of a biomaterial are the determining factor to define the mechanical properties. These characteristics are controlled by the synthesis process and its intrinsic parameters. In addition, all factors, such as chemical composition of cement, relative proportions of reactants, powder or liquid additives acting as accelerators or retarders, particle size, liquid-powder ratio (L/P ratio) (Figure 1), applied pressure during synthesis, and aging conditions, will affect its mechanical properties [36].
Microstructure and porosity of CPCs according to particle size and L/P ratio. (A) When the particle size is small, there is an increase in the specific surface area, resulting in the degree of supersaturation. This phenomenon favors the nucleation of crystals and leads to the formation of large quantities of small needle-like crystals. When the particles are larger, the formation of larger plate crystals occurs. Small pores are formed in the cement where small particles are used. (B) Porosity and pore size distribution also vary with the L/P ratio. When the L/P ratio is low, the space between the particles in the mixture decreases, leading to a more compact structure of crystal agglomerates. In contrast, when the L/P ratio increases, the total porosity of the cement increases, and the larger pores are formed due to the increased separation between the aggregates (adapted from [
Unlike bioceramics, which require sintering at high temperatures, CPCs are formed through a dissolution-precipitation process at room or body temperature. During this process, a crystalline matrix is formed in which with the passage of time and matrix it becomes increasingly dense until reaching the maximum mechanical properties [36].
Normally, microporosity ranges between 30 and 55% and is dependent on the L/P ratio; the higher this ratio is, the greater the microporosity [37].
Although porosity is a disadvantage to be applied in load situations, porosity is sought to improve the resorbability of the material and the extent of bioactivity, increasing the surface area available for reaction. The presence of a certain level of porosity makes this material a good carrier for controlled drug systems [34].
It is possible to promote the creation of macropores in CPCs through two techniques. The leaching of porogen after the adjustment creates macropores; however, it is necessary to add large amounts of porogen, which may compromise the injection process [37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47]. The formation of the pores can also be achieved by the formation of gas foam prior to fixation, but the release of the gas after the introduction of the implant may be harmful to the organism [46, 48, 49, 50, 51, 52]. In order to overcome the drawbacks of the techniques mentioned above for obtaining macroporous structures of CPCs, Ginebra et al. proposed the use of self-adjusting injectable macroporous foams composed of a protein-based foaming agent and CPC paste [52].
Regardless of the composition of CPC (apatite or brushite), the strength decreases globally with increased porosity, which is a common occurrence in several materials mainly in porous materials used in bone replacement [36]. In addition to the pore fraction effect, pore size also significantly affects the strength of CPCs. Bai et al. [53] found that the compressive strength is inversely proportional to the size of the macropores through a study in materials with equivalent total porosity but with different sizes of macropores. Through Griffith’s classical theory [36], which relates strength to the critical size of the fault, macropores can be considered as failures, thus reducing strength. In addition to the quantity and size of the pores, the characteristics of the crystals (quantity, size, morphology, and distribution) also influence the strength of these cements. The growth of the crystals depends on the kinetics of the dissolution-precipitation reaction of the cement, being controlled by many factors. The smaller the particle size of the starting materials, the faster the material will be converted to apatite, and the crystals formed will not have time to grow. The small size of these crystals will lead to a more dense and crystalline organization, increasing the strength of the cement [54].
One of the conditions that influence the kinetics of apatite formation is aging. The transformation of the initial reactants into apatite becomes faster at higher temperatures, thus making the structure more homogeneous and denser, making it more resistant. In contrast, high temperatures also cause the development of precipitated apatite crystals more rapidly, resulting in larger crystals, which will negatively influence the resistance [55].
The fixation kinetics may be influenced by the presence of accelerating or retarding substances which are added to the mixture and is an important factor in determining the strength of the structure.
Bermudez et al. [56] and Yang et al. [57] found that by adding certain amounts of apatite, the hardening time of the CPCs is lower, and the compressive strength increases considerably. α-Hydroxylic acids (citric acid or glycolic acid) and their salts (sodium citrate) are also used as retarders. The addition of the same allows to mix and to process more easily, reducing the L/P ratio associated with a decrease of the porosity, improving the strength [58, 59, 60, 61, 62, 63, 64]. However, it is necessary to take into account an optimum concentration of these additives since the excess may lead to the opposite effect and decrease the force [63]. In summary, the mechanical properties of the CPCs, and in particular the resistance, depend strongly on the microstructure, which is related to the synthesis process, chemical composition, powder or liquid additives acting as accelerators or retarders, particle size, L/P ratio, and aging conditions. In addition, it has been found that crystalline structures have, with smaller crystals, become more compact and homogeneous and appear to give better mechanical properties than those with larger crystals.
Strength has been the main property to be studied when evaluating mechanical performance; however, the CPCs applied in bone defects are also subject to cyclic loading, and the resistance of CPC to fractures cannot be evaluated by strength alone. In order to adequately evaluate the ability to resist fractures, it is also necessary to take into account fracture toughness that describes the strength of a material containing cracks or notches to resist crack propagation [65, 66].
The toughness of a material depends on its nano-/microstructure and on the possibility of promoting the hardening activation mechanism [67, 68]. Without the activation of significant hardening mechanisms, the fracture toughness of CPCs is very low. Due to the low values of toughness, CPCs are very sensitive to defects and failures. The reliability, that is, the likelihood of failure of brittle materials, is also an important factor when one thinks of applying the cement to load-bearing sites. As previously mentioned, it is possible to improve the hardening mechanism by decreasing porosity, as it is the most damaging factor in mechanical performance. To overcome this problem, it is necessary to decrease the volumetric fraction of the pores in order to achieve a more dense matrix by compacting the cement paste prior to hydration.
Studies have shown that compaction pressure would significantly increase tensile strength [69]. However, when the compaction pressure is above 100 MPa, only a slight decrease in porosity is achieved, and the diametral tensile strength is not substantially improved.
In addition, the use of this method to promote the hardening has the same function of decreasing the L/P ratio, which would influence the workability and injectability of cement pastes, which may exclude the application of this cement in minimally invasive surgery.
In order to overcome this disadvantage, researchers added certain amounts of citric acid to the cement liquid to evaluate its effect on the fixability and fixation properties of apatite cements and found that this addition effectively improves the mechanical properties of the cement. According to this prominent effect of citric acid on strength improvement, Barralet et al. [61] and Gbureck et al. [60] added sodium citrate and compacted the resulting cement slurry, obtaining compressive strengths near the resistance of the cortical bone, that this composition can be used in load-bearing locations. This resistance can also be achieved by other factors, especially in the use of citric acid but without applying external pressure, varying the particle size and distribution of powdered reagents [70].
The main chemical reaction occurring in the setting mechanism is similar in all these systems of cements and can be understood by analyzing the behavior of the solubility of the existing compounds in the composition [71, 72, 73]. During the fixation reaction, the two mechanisms present are dissolution and reprecipitation [23]. The dissolution is activated by the release of the calcium and phosphate ions from the starting materials, leading to supersaturation in the solution. After the ionic concentration reaches a critical value, the nucleation of the new phase occurs, usually around the powder particles. This new phase develops in line with the dissolution of the reactants [74].
In the dissolution/reprecipitation mechanism, the formation of the precipitates depends on the relative stability of the various calcium phosphate salts in the system. The existence of a precipitate that grows in the form of the crystal agglomerates determines the force that a cement can acquire [74]. The solubility phase diagram predicts this reaction, describing the evolution of the solubility of a compound through the logarithm of the total concentration of calcium (or phosphate) as a function of pH [71, 72, 73].
The less stable phase of calcium phosphate tends to dissolve to form a more stable and less soluble phase.
As mentioned above, apatite is the most stable calcium phosphate (less soluble at a pH above 4.2 at room temperature), and brushite is most stable at a pH below 4.2 [71].
In these reactions the amount of water consumed is nonexistent, or almost nil, being necessary only for the reagents to become viable and to allow homogeneity in the solution. For this reason, water becomes one of the main contributions to the development of porosity in cement, and, therefore, CPCs are intrinsically porous materials.
In addition to this material, in situ, the body temperature allows its molding after mixing, to be injectable and therefore to be used as a carrier for biological drugs or molecules [75, 76, 77].
In the industry, the biological responses of materials have been increasingly a property to be taken into account, focusing on improving cell and tissue CPC interactions, as well as their applications in bone tissue engineering [78, 79, 80, 81, 82]. The improvement of these interactions is one important factor for the application of biomaterials and their commercialization for clinical applications.
Studies evaluating the in vivo behavior of CPCs show high levels of biocompatibility and osteoconductivity, stimulating tissue regeneration [5, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92]. Most apatite cements are reabsorbed by cell-mediated mechanisms. The function of the osteoclastic cells in this process is to degrade the materials layer by layer, starting from the surface which is in contact with the bone to the nucleus. The biodegradability of apatite CPCs is slow but higher than that of the synthesized hydroxyapatite. As noted above, the rate of degradation of apatite cements is controlled by precipitated hydroxyapatite (PHA) crystallinity, specific surface area, and matrix porosity.
The cements based on brushite have a higher reabsorption rate than apatites due to their superior stability in the biological environment [89, 90, 91]. However, there is a possibility in vivo of brushite cements to be transformed into PHA and thus reduce their total degradation rate. In order to retard this reaction or to avoid magnesium salts have been added [92].
At a biological level, the mechanism of dissolution is mediated by the action of physiological solutions or by cell-mediated processes (phagocytosis) [93]. Bone replacement depends on the age, sex, and general metabolic health of the host and the site and volume where it is applied, porosity, crystallinity, chemical composition, particle size, and L/P ratio of the cement. Considering these factors, it can take from 3 to 36 months for the cement to be completely reabsorbed and replaced with bone. However, further studies are needed to confirm the total resorption of the material in order to be applied clinically [94]. Studies have revealed bone development around calcium phosphate cements, demonstrating osteoconductive and osteoinductive characteristics in several cases. It has been shown that within 2 weeks, spicules of living bone with normal bone marrow and gaps in osteocytes can be identified in the cement. After 8 weeks, the cement is almost completely surrounded by new bone. At this stage, no cement reabsorption is typically observed [94]. Figure 2 shows a progressive resorption of the calcium phosphate cement matrix, with tricalcium phosphate (TCP) granules embedded in a matrix of dicalcium phosphate dihydrate (DCPD) and parallel new bone formation, in a drill hole. After 2 weeks almost the entire surface of the cement was in direct contact with the margins of the bone defect. After 4 weeks, occasional granules of β-TCP and the newly formed bone islets are visible. This area expanded after 6 weeks, involving a progressive reabsorption of the cement matrix and parallel neoformed formation [81].
Image of the drill hole with progressive resorption of the calcium phosphate cement matrix, during 8 weeks [
The importance given in the use of apatites in bone replacement is due to the fact that this mineral is the base of the main inorganic part of hard tissues. In fact, nonstoichiometric or calcium-deficient hydroxyapatite (CDHA) is the main mineral phase characteristic of human bones [94]. The CPCs consist of a network of calcium phosphate crystals, with chemical composition and crystal size that can be modified to approximate the biological hydroxyapatite that exists in the living bone [95, 96].
In this regard, it is necessary to clarify that even though the stoichiometric hydroxyapatite has a fixed composition, the apatite structure may exist in a variety of compositions. CDHA comprises in its composition the possibility of varying amounts of calcium, where it is possible to present a completely deficient structure based on this base element. The composition may be expressed as Ca10 −
Apatite cements may form PHA or CDHA through a precipitation reaction. The synthesis of these cements allows the incorporation of different ions in their composition, depending on the initial compounds. The formation of hydroxyapatite that occurs in the cement is compared to the process of formation of new bone and is also seen as a biomimetic process, because it occurs at body temperature and physiological environment. This may explain the fact that the hydroxyapatite formed in the reactions of calcium phosphate cements is much more similar to biological apatites than the ceramic hydroxyapatite resulting from high-temperature sintering processes [34].
The CPCs lead to the formation of PHA or CDHA and can be divided into three systems (single compound, two compounds, more than two compounds), taking into account the number and type of calcium phosphates used in the synthesis [97].
Monocomponent CPCs are those having a single calcium phosphate reagent that hydrolyzes to form PHA or CDHA. Taking into account that at pH 4.2 the hydroxyapatite is less soluble, any other calcium phosphate present will dissolve, and the PHA will tend to precipitate. However, when the formation of PHA occurs, from the hydrolysis of calcium phosphate, the reaction mechanism becomes very slow, due to a decrease in the level of supersaturation, as the reaction proceeds [13]. In this in which only one compound is present, no release of any acid or no base occurs due to the Ca and P ratio being maintained [34, 35].
The second type of cement that may exist is composed of two calcium phosphates, one acid and the other basic, where they adjust after an acid–base reaction. The most commonly used compound is usually tetracalcium phosphate (TTCP), as it is the only calcium phosphate with a Ca/P ratio higher than PHA. Therefore, TTCP can be combined with one or more calcium phosphates with lower Ca/P ratios to obtain PHA or CDHA, avoiding the formation of acids or bases as final products. The combinations that have been more studied seek to produce cements that adjust to the body temperature in a range of pH around the neutral [34].
The third possible system consists of more than two compounds, including calcium phosphates and other salts. For example, a cement proposed by Norian Corporation [5] is used where calcium phosphates with a Ca/P ratio lower than PHA and CaCO3 are added as an additional source of calcium. The initial configuration process involves the formation of DCPD, later forming dahllite, a carbonated hydroxyapatite similar to the bone mineral [5].
Apatitic CPCs appear as a viscous, easily moldable material; however, their injection is difficult. Figure 3 shows the microstructure of an apatitic cement after setting. The setting time can also be reduced by means of additives such as with the introduction of PHA particles. These changes in the composition may lead to an adjustment time in the range of about 15 minutes. When hardening of the cement paste occurs too fast, the hardened cement must be milled to render it viscous again. Subsequently, the paste hardens due to the precipitation of PHA.
Microstructure of an apatitic calcium phosphate cement after setting, showing the micro−/nanosize pore structure formed by the entanglement of the precipitated crystals [
After implantation, the mechanical properties can be altered. Investigations indicate that the mechanical properties of apatite CPC tend to increase, unlike brushite cement, which initially decrease and increase when the bone develops [98, 99].
Brushite (DCPD) is an acidic calcium phosphate that has been found in some physiological sites, for example, in bones [100]. Unlike hydroxyapatite, brushite is metastable under physiological conditions [101] and for this reason reabsorbed much faster than CPC apatite; however, there are studies that conclude that DCPD in vivo tends to convert to PHA [26]. Some CPCs were designed to provide brushite as the final product.
Several combinations of compounds have been proposed for the formation of brushite cements; most are β-tricalcium phosphate (β-TCP) and an acid component, namely, monocalcium phosphate monohydrate (MCPM) or phosphoric acid [102, 103, 104].
The reaction leading to the formation of brushite CPCs is an acid–base reaction. The brushite paste is acidic during sedimentation because brushite can only precipitate at a pH value below ~6 [105]. The pH of the cement paste tends to change slowly toward equilibrium pH [106]. If the slurry contains an excess of basic phase, the pH tends to equilibrate by crossing the solubility of the base phase with that of the DCPD. The time of stabilization of brushite CPC depends greatly on the solubility of the basic phase: the higher the solubility of the basic phase, the faster the defined time. For example, hydroxyapatite (HA) + MCPM blends have an adjustment time of several minutes. The β-TCP + MCPM mixtures have an adjustment time of 30–60 seconds [107, 108]. However, compounds that inhibit the development of DCPD crystals can be added, increasing the settling time of the β-TCP + MCPM mixtures [109]. The brushite CPC can initially be very liquid and still be defined within a short period of time, unlike the apatite CPC. The brushite CPC is slightly weaker (tensile strength of 10 MPa [110] and compressive strength of 60 MPa) than the apatite CPC (tensile strength of 16 MPa [111] and compressive strength of 83 MPa [112]). The mechanical properties of apatite CPC increase [98], whereas those of brushite CPC decrease [99] This latter phenomenon is attributed to the greater solubility of DCPD in relation to that of PHA [113]. After a few weeks of implantation, the mechanical properties of brushite CPC are promoted by bone growth [99]. Although brushite CPC exhibits biocompatible properties, inflammatory reactions have been reported with the excessive addition of brushite CPC [114]. Investigations indicate that these reactions are due to the transformation of DCPD into PHA [115]. This reaction releases large amounts of acid. The transformation of DCPD into PHA can be avoided with the addition of magnesium ions to the cement [116]. Unlike apatite CPC, brushite CPC cannot be reabsorbed exclusively by osteoclastic activity but also by simple dissolution. Therefore, brushite CPCs degrade at a faster rate than the apatite CPC.
Although brushite demonstrates a higher solubility rate than the other calcium phosphate phases, it is a precursor of the most stable HA phase [117, 118, 119, 120]. For this reason, DCPD coatings as an initial step to obtaining HA have been widely used. The synthesis of HA through precipitation mechanisms results in compacted crystals but with sizes difficult to control. Using DCPD as a precursor becomes favorable since it is possible to modify the crystal size of the DCPD through homogeneous precipitation and can be converted directly into HA [119]. In environments with a pH > 6–7, brushite becomes unstable and becomes the most favorable HA phase [121, 122]. The fact that DCPD is able to be more soluble leads to its use in metal implants as a means of increasing the amount of calcium and phosphate ions available in the surrounding tissue of the implant to promote increased osseointegration [118].
The biocompatibility of DCPD as a coating has been demonstrated in several cell lines as, for example, in pre-osteoblastic macrophages [123, 124] and fibroblastic cells [125]. The biocompatibility of DCPD has also been demonstrated when used at a cranial defect site in sheep [126], and the formation of new bone was observed in the absence of inflammation [81]. A clinical study in humans in 2010 effectively used a brushite cement for the repair and increase of pterionic craniotomies, with no inflammation occurring [127].
Figure 4 summarizes how the CPCs are classified by type and number of initial reagents as well as their final product.
Classification of calcium phosphate cements, with examples of the most common formulations. From top to bottom, the cements are classified by the type of end product (apatite or brushite), a number of components in the solid phase (single or multiple), type of setting reaction (hydrolysis or acid–base reaction), setting mechanism, and microstructure evolution during setting (adapted from [
The main requirements for a substrate to have potential as a drug carrier are to have the ability to incorporate it, to retain it at a specific site, and to distribute it progressively over time in surrounding tissues. In addition, it is beneficial that the material is injectable and biodegradable [77].
Calcium phosphate cements, in addition to allowing hardening at room or body temperature, allow the insertion of various components due to their intrinsic porosity. It is possible to incorporate drugs, biologically active molecules, or even cells without their functions being altered by the effect of temperature or even losing their activity during the procedure (Figure 5). This change in the CPCs offers new properties in addition to the osteoconductive characteristic, namely, to increase its capacity for bone regeneration or to support in disorders or pathologies, such as bone tumors or osteoporosis [35].
Scheme about the possible applications of calcium phosphates in the biomolecules and drug delivery (adapted from [
It is necessary to take into account that the performance of the drug delivery depends on the structural characteristics such as the specific surface area, permeability, matrix degradation rate, drug solubility, or the interaction itself between the matrix and the inserted drug.
The interaction between the drug and the cement matrix is defined by the drug insertion procedure. Usually, the drugs are added as a powder to the solid phase or dissolved in the liquid part. The method that allows better homogenization of the drug in the matrix is in the liquid phase [35].
Another method for inserting the drug into the matrix is by impregnating solid beads or granules from the cement with a drug solution. This method continues to present benefits compared to other conventional methods even with its impaired injection process. The advantages associated with this method are due to the fact that the consolidation of the material (dissolution-precipitation reaction) leads to the production of hydrated matrices with large specific surface areas that allow the loading of drugs and their release mechanism to be favorable [35].
The two drug encapsulation processes differ greatly in the structural properties of the matrix. In one method the drug is incorporated in the initial phase together with the cement reactants while the matrix is still evolving. Thus, the hardening can last for hours or even days until the suspension of particles evolves into a network of interlaced crystals. In the other case, if the drug is added to the preconceived cement, the matrix structure will always be stable throughout the release process, in addition to possible degradation, and therefore the results cannot be extrapolated to the previous situation. This highlights the need for the studies to be carried out, taking into account the actual conditions of application. The alternative method is to incorporate the drug into polymeric microspheres prior to mixing in the cement. This procedure has two advantages over the other methods presented. It is possible to modify the release kinetics of the drug, and the degradation of the microspheres generates an array capable of being more easily reabsorbed and remodeled [35].
The incorporation of drugs can influence the entire mechanism of action of the cement and compromise its purpose, changing the fit kinetics, rheological characteristics, and microstructural development. For example, molecules that interact with calcium or phosphate ions promote a coprecipitation during the fit or form complexes with Ca2+, promoting a delay in precipitation and modifying viscosity, set time, and cement properties [72, 129, 130].
In addition to the influence that the drug has on the cement matrix, it is also necessary to take into account the influence of the cement on the stability of the drug or bioactive molecule. Due to the dissolution-precipitation process, there is a change in the surrounding pH as well as the change in ionic concentrations, which may influence the functionality of the drug and its release.
Thus, it is beneficial to study the release of drugs introduced from already synthesized cements.
Recently, studies have been developed related to the incorporation of antibiotics, as a preventive method of infections resulting from surgeries or as treatment of bone infections. In addition to antibiotics, studies with anti-inflammatories, antitumor drugs, or hormones have also been disclosed. In another aspect, the incorporation of factors that stimulate bone regeneration, such as bone morphogenetic proteins (BMP) or transforming growth factors-β (TGF-β), has been studied [77, 131].
Growth factors are a large group of proteins that interact at the cellular level [35]. The major families of these proteins are the transforming growth factor-beta superfamily responsible for promoting bone regeneration. The BMPs are part of the TGF-β superfamily and have been widely used in bone regeneration. It is known to play a role as an activating agent in the various biological phenomena responsible for bone formation and therefore can accelerate bone growth. These BMPs stand out from the other growth factors of the large TGF-βSF group because they are osteoinductive. That is, the BMPs act at the level of cell differentiation transforming the pluripotential cells into bone-forming cells, aiding in bone formation outside the bone tissue [77].
These proteins have been produced at an industrial level with a high level of purity; however, it is necessary that their administration is controlled and with adequate therapeutic levels as well as adapted to the tissue targets. In fact, it is known that the injection of such substances alone cannot induce the formation and regeneration of tissues since the protein diffuses very rapidly from the site of implantation. Thus, the CPCs present themselves as good substrates and carriers for these bioactive molecules, also improving their function as osteoconduction [77].
Studies have shown that the superfamily of growth factors stimulates osteoblast proliferation and collagen synthesis in vitro [132] and may increase the size of the cortical bone when applied near the periosteum in vivo [133].
This improvement in bone growth, when applied to cement with these molecules, is due to the adsorption of large doses of rhTGF-β1 on the surface of the material [134, 135].
Despite this accumulation of the growth factor to the surface, there is a homogenous distribution throughout the cement mass, increasing the time of the release of the growth factors while the degradation of the matrix occurs.
Blom et al. showed that the addition of a human recombinant TGF-β1 (rhTGF-β1) to a CPC in the adjustment phase stimulated the differentiation of pre-osteoblastic cells using primary mouse bone cells in vitro [136].
In contrast to the kinetics of drug release, the release of these factors becomes much slower [137].
It has been determined that in the first days, the release rate of the components is higher because the initial release is only of the material present in the surface layer that is in contact with the medium. This increase in the rhTGF-β1 release was confirmed when the area in contact with the medium occurred by fragmentation. The same phenomenon was observed when BMP-2 human recombinant microspheres were introduced into the CPC. The release of the factor was quite limited due to the possible physical entrapment of the microparticles inside the porous cement. According to the authors, the nanoporosity of CPC not only did not facilitate the release of the protein but could also limit it because of the high binding affinity of the protein by CPC [138].
Haddad et al. [139] investigated the action of implantation of cement loaded with BMP-2 in the bone repair of a critical-sized calvarial vault defect in rabbits. Compared with control, an increase in bone formation was observed at 45% after 12 weeks of implantation.
Other investigations by Seeherman et al. [140, 141] also demonstrated the efficiency of these combined systems (BMP-2/cement). For example, these composites accelerated the filling of a bone defect by 40% after approximately 4 months of implantation, compared to cement without the protein. This study was done in a primate fibula osteotomy [140].
The composite used in the abovementioned study was also used in rabbit bone defects. After 4 weeks of implantation, an acceleration of reabsorption was observed as well as filling of the defect compared to the base cement. This acceleration led to the complete filling of the defect with new bone 8 weeks after the implant.
To avoid infections resulting from orthopedic surgery, which usually lead to bone loss or subsequent removal of the implant, alternatives such as antibiotic delivery have been used on the site [142, 143, 144]. This transport is usually done using poly(methyl methacrylate) (PMMA) or by encapsulating the drug in the CPC matrix. PMMA beads have the drawback that they are not resorbable and require further surgery to remove them and place new antibiotic-loaded spheres if the goal is to prolong the treatment [145, 146, 147, 148]. Faced with this drawback, CPCs have been widely studied as degradable materials capable of carrying antibiotics [77, 145, 148, 149, 150, 151, 152, 153, 154, 155]. However, there is a risk of creating bacterial resistance due to low doses of release [156, 157, 158]. Thus, the use of surface functionalization of biomaterials as well as the coating of implant surfaces with silver ions has been recurring, conferring antibacterial properties [159, 160, 161, 162, 163].
The antimicrobial properties of Ag+ ions have been investigated and studied in the field of biomedical engineering [164]. It has been found that bacteria hardly gain resistance to silver-based products and low concentrations are required to have a bactericidal effect [165].
Therefore, both metallic silver and ionic silver were incorporated in several biomaterials, HA [166, 167, 168, 169], and bioactive glasses [164, 170, 171, 172]. In both structures, silver has relatively low toxicity to human cells [173, 174, 175, 176].
Ewald et al. evaluated the antimicrobial properties of silver-loaded bone cements as well as their osteoconductive and resorbable properties. The reagents used were both α- and β-tricalcium phosphates combined with slightly acidic compounds to form HA or brushite cement. This study revealed that it is possible to synthesize cements with antimicrobial activity with effects comparable to antibiotic treatments. Figure 6 shows the inhibition of both
Bacterial activity of
Several studies have been carried out using silver-doped calcium phosphate cements, and the results have been satisfactory, demonstrating inhibitory effect against certain bacteria [178].
In addition to silver, other ions have been incorporated into materials composed of calcium phosphate. Doping with Co2+ showed proangiogenic effects [179, 180]. Modification with Cu2+ increased the rate of vascularization [181]. The influence of the introduction of Co2+, Cu2+, and Cr3+ on calcium phosphate cement was investigated, evaluating the material properties, proliferation, and osteogenic differentiation of human mesenchymal stem cells in vitro [182]. The Cr3+ and Cu2+ ions, in this case with less evidence, had positive effects on osteogenic proliferation and differentiation.
Despite all the positive results of this incorporation, the examinations that evaluate the osteogenic capacity in vitro are not enough to estimate the clinical performance of these materials in the bone graft. Since the balance between bone neoformation and material resorption is crucial for successful remodeling, in vitro analysis of osteoclast-mediated degradation of materials is a logical next step in evaluating material remodeling in vivo [183].
However, it is necessary to take into account the dose that is used in the doping process, as investigators have concluded that doses in certain amounts of Cu2+ and Co2+ can cause cytotoxic reactions to osteoclasts and progenitors of osteoclasts during the initial release of Cu2+ and Co2+, respectively. Cements at lower doses are beneficial to bone regeneration since Cu2+ at 18 μM completely inhibits reabsorption (but not the formation of osteoclasts), which may be beneficial for patients with osteoporosis and imbalance between bone formation and resorption. The addition of Cr3+ to brushite cements increases osteoclastic reabsorption and increases the viability of osteoprogenitor cells compared to cement without the addition of ions [182]. Therefore, Cr3+-doped brushite cements are suggested as a promising new material for application in bone regeneration.
The 3D printing technique, or additive manufacture (AM), is based on the addition of layers of powder material producing solid materials with adjustable porosity, through a digital geometric model. This method has been the subject of much research in the medical field such as in the synthesis of the customized scaffold [184]. In addition to the economical and fast production that 3D printing allows, it also allows the manufacture of pieces with high geometric complexity. All these advantages have made 3D printing very useful in the field of biomedical and tissue engineering due to the ability to replicate the complicated architecture as well as the cellular heterogeneity present in tissues and organs. The bone presents itself as an exquisite structure due to the existence of a complex compound of minerals and an organic matrix. Taking into account this organization, there are several size scales, and it is possible to easily reproduce this structure through 3D printing. In addition, 3D printing is suitable for producing structures derived from medical images, such as CT scans [185, 186].
Recently, the manufacture of the customized scaffolds of the calcium phosphate cements by 3D printing has been described. During printing, highly viscous or pasty materials are dispensed through an adjustable dosing nozzle, resulting in the deposition of CPC layers on a platform with a liquid or air as a plotting medium. After the stabilization of the scaffolds, the water adjustment reaction begins. These stabilization and hardening conditions allow the integration of biological molecules at specific sites [187].
In this way, it is possible to create scaffolds, based on calcium phosphates, more complex with specificities that can promote higher bioactivity or introduce drugs or other therapeutic components, taking into account the patients’ needs (Figure 7).
Scheme of the 3D printing system of the calcium phosphate bone cement scaffolds and its advantages due to the possibility of improving the settings.
In addition, this technique allows the combination of components (i.e., CPC and alginate) to produce structures more resistant to compression and with improved toughness compared to pure CPC supports [188].
Due to its bioactivity, biocompatibility, osteoconductivity, and osteoinductivity, calcium phosphate cements present an advantageous option in the field of bone tissue engineering, taking into account all the needs that this application demands. In addition, it may be used as scaffolds and transport medium for various biological molecules such as stem cells, drugs, or growth factors. It is also worth mentioning the possibility of producing structures of these cements through 3D printing technology, where it is possible to manufacture intrinsically complex biomimetic structures due to the degree of precision of this technique.
The possibility of building calcium phosphate cements, involving the incorporation of several types of cells, growth factors, molecules, or bioactive glasses, allows favorable results in the vascularization of bone tissues and, consequently, in bone regeneration. This feature, particularly appreciated in large bone regenerations, will allow a considerable increase in the use of these structures in clinical applications. However, more research is needed to consolidate and understand all the information associated with the fundamental mechanisms that promote the development of tissue engineering and regenerative medicine.
The success associated with biomaterials has been underestimated maybe because they have been used clinically for more than 40 years. However, there is still a huge diversity of calcium phosphate-based materials that have not been fully investigated.
AM | manufacture additive |
BMP | bone morphogenetic proteins |
CDHA | calcium-deficient hydroxyapatite |
CPCs | calcium phosphate cements |
DCPA | dicalcium phosphate anhydrous |
DCPD | dicalcium phosphate dihydrate |
HA | hydroxyapatite |
L/P ratio | liquid-powder ratio |
MCPM | monocalcium phosphate monohydrate |
PHA | precipitated hydroxyapatite |
PMMA | poly(methyl methacrylate) |
TCP | tricalcium phosphate |
TGF-β | transforming growth factors-beta |
TTCP | tetracalcium phosphate |
rhTGF-β1 | human recombinant TGF-β1 |
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The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"46296",doi:"10.5772/57398",title:"Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity",slug:"physiological-role-of-amyloid-beta-in-neural-cells-the-cellular-trophic-activity",totalDownloads:5907,totalCrossrefCites:19,totalDimensionsCites:32,abstract:null,book:{id:"3846",slug:"neurochemistry",title:"Neurochemistry",fullTitle:"Neurochemistry"},signatures:"M. del C. Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. 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Luna-Muñoz and M.A.\nMeraz-Ríos",authors:[{id:"42225",title:"Dr.",name:"Jose",middleName:null,surname:"Luna-Muñoz",slug:"jose-luna-munoz",fullName:"Jose Luna-Muñoz"},{id:"114746",title:"Dr.",name:"Marco",middleName:null,surname:"Meraz-Ríos",slug:"marco-meraz-rios",fullName:"Marco Meraz-Ríos"},{id:"169616",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Cardenas-Aguayo",slug:"maria-del-carmen-cardenas-aguayo",fullName:"Maria del Carmen Cardenas-Aguayo"},{id:"169857",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Silva-Lucero",slug:"maria-del-carmen-silva-lucero",fullName:"Maria del Carmen Silva-Lucero"},{id:"169858",title:"Dr.",name:"Maribel",middleName:null,surname:"Cortes-Ortiz",slug:"maribel-cortes-ortiz",fullName:"Maribel Cortes-Ortiz"},{id:"169859",title:"Dr.",name:"Berenice",middleName:null,surname:"Jimenez-Ramos",slug:"berenice-jimenez-ramos",fullName:"Berenice Jimenez-Ramos"},{id:"169860",title:"Dr.",name:"Laura",middleName:null,surname:"Gomez-Virgilio",slug:"laura-gomez-virgilio",fullName:"Laura Gomez-Virgilio"},{id:"169861",title:"Dr.",name:"Gerardo",middleName:null,surname:"Ramirez-Rodriguez",slug:"gerardo-ramirez-rodriguez",fullName:"Gerardo Ramirez-Rodriguez"},{id:"169862",title:"Dr.",name:"Eduardo",middleName:null,surname:"Vera-Arroyo",slug:"eduardo-vera-arroyo",fullName:"Eduardo Vera-Arroyo"},{id:"169863",title:"Dr.",name:"Rosana Sofia",middleName:null,surname:"Fiorentino-Perez",slug:"rosana-sofia-fiorentino-perez",fullName:"Rosana Sofia Fiorentino-Perez"},{id:"169864",title:"Dr.",name:"Ubaldo",middleName:null,surname:"Garcia",slug:"ubaldo-garcia",fullName:"Ubaldo Garcia"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9707,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7183,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1455,totalCrossrefCites:13,totalDimensionsCites:24,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192987,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4596,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3523,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3609,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1349,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82319",title:"Traumatic Optic Neuropathy",slug:"traumatic-optic-neuropathy",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.104731",abstract:"Traumatic optic neuropathy (TON) is a specific neurological sequence of traumatic brain injury (TBI). It has a different mechanism than other most neurologic complications of head trauma and its consequences can be devastating. The damage can be from direct penetrating trauma or bone fracture injuring the optic nerve directly or secondary to indirect blunt trauma (usually causing traction). The diagnosis of TON is based on the clinical history and examination findings indicative of optic neuropathy, especially the presence of defective pupillary light response. TON can cause only mild vision loss but, in some cases, severe vision loss is present. Imaging findings can support the diagnosis, and provide information on the mechanism as well as treatment options. The treatment options include observation alone, systemic steroids, erythropoietin, surgical decompression of the optic canal, or combination. The evidence base for these various treatment options is controversial and each treatment has its side effects and risks. Poor prognostic factors include poor visual acuity at presentation, loss of consciousness, no improvement in vision in the first 48 hours, and evidence of optic canal fractures on neuroimaging.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Ainat Klein and Wahbi Wahbi"},{id:"82203",title:"Resting-State Brain Network Analysis Methods and Applications",slug:"resting-state-brain-network-analysis-methods-and-applications",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104827",abstract:"Resting-state fMRI has been widely applied in clinical research. Brain networks constructed by functional connectivity can reveal alterations related to disease and treatment. One of the major concerns of brain network application under clinical situations is how to analyze groups of data to find the potential biomarkers that can aid in diagnosis. In this paper, we briefly review common methods to construct brain networks from resting-state fMRI data, including different ways of the node definition and edge calculation. We focus on using a brain atlas to define nodes and estimate edges by static and dynamic functional connectivity. The directed connectivity method is also mentioned. We then discuss the challenges and pitfalls when analyzing groups of brain networks, including functional connectivity alterations, graph theory attributes analysis, and network-based statistics. Finally, we review the clinical application of resting-state fMRI in neurorehabilitation of spinal cord injury patients and stroke patients, the research on the mechanism and early diagnosis of neurodegenerative diseases, such as multiple system atrophy, as well as the research on brain functional network alteration of glioma patients.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Yunxiang Ge and Weibei Dou"},{id:"82099",title:"Recent Advances in the Development of Biofluid-Based Prognostic Biomarkers of Diffuse Axonal Injury",slug:"recent-advances-in-the-development-of-biofluid-based-prognostic-biomarkers-of-diffuse-axonal-injury",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.104933",abstract:"Even though head injury is a silent pandemic of the century producing immense social and economic impact, predictive models have not been established to develop strategies promoting the development of reliable diagnostic tools and effective therapeutics capable of improving the prognosis. Diffuse axonal injury (DAI) is a type of traumatic brain injury (TBI) that results from a blunt injury to the brain. Discovering biomarkers for DAI have been a matter of debate and research. A number of studies have reported biomarkers that are correlated with severity of TBI but no conclusive and reproducible clinical evidence regarding the same has been put forward till now. Additionally, many DAI biomarkers have limitations so that they cannot be generalized for universal applications. The properties of these biomarkers should be extensively researched along with the development of novel biomarkers to aid important clinical decisions for the benefit of the society. This chapter summarizes the existing biofluid-based biomarkers, critically examines their limitations and highlights the possibilities of a few novel biomolecules as prognostic biomarkers of DAI.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Vinu V. Gopal, Rinku Raj Mullasseril and Goutam Chandra"},{id:"81998",title:"Understanding the Neuropathophysiology of Psychiatry Disorder Using Transcranial Magnetic Stimulation",slug:"understanding-the-neuropathophysiology-of-psychiatry-disorder-using-transcranial-magnetic-stimulatio",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.103748",abstract:"Transcranial magnetic stimulation (TMS) is a safe and non-invasive tool that allows researchers to probe and modulate intracortical circuits. The most important aspect of TMS is its ability to directly stimulate the cortical neurons, generating action potentials, without much effect on intervening tissue. This property can be leveraged to provide insight into the pathophysiology of various neuropsychiatric disorders. Using multiple patterns of stimulations (single, paired, or repetitive), different neurophysiological parameters can be elicited. Various TMS protocol helps in understanding the neurobiological basis of disorder and specific behaviors by allowing direct probing of the cortical areas and their interconnected networks. While single-pulse TMS can provide insight into the excitability and integrity of the corticospinal tract, paired-pulse TMS (ppTMS) can provide further insight into cortico-cortical connections and repetitive TMS (rTMS) into cortical mapping and modulating plasticity.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Jitender Jakhar, Manish Sarkar and Nand Kumar"},{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:30,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"}],onlineFirstChaptersTotal:13},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:317,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 28th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:35,paginationItems:[{id:"82409",title:"Purinergic Signaling in Covid-19 Disease",doi:"10.5772/intechopen.105008",signatures:"Hailian Shen",slug:"purinergic-signaling-in-covid-19-disease",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82212",title:"Protein Prenylation and Their Applications",doi:"10.5772/intechopen.104700",signatures:"Khemchand R. Surana, Ritesh B. Pawar, Ritesh A. Khairnar and Sunil K. Mahajan",slug:"protein-prenylation-and-their-applications",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Modifications of Biomolecules",coverURL:"https://cdn.intechopen.com/books/images_new/11098.jpg",subseries:null}}]},overviewPagePublishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. 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He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}}]}},subseries:{item:{id:"39",type:"subseries",title:"Environmental Resilience and Management",keywords:"Anthropic effects, Overexploitation, Biodiversity loss, Degradation, Inadequate Management, SDGs adequate practices",scope:"\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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