\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"2575",leadTitle:null,fullTitle:"Prolactin",title:"Prolactin",subtitle:null,reviewType:"peer-reviewed",abstract:"Prolactin is a polypeptide hormone that is synthesized in and secreted from the lactotrophs of the anterior pituitary gland. We are now aware that synthesis and secretion of prolactin is not restricted to the anterior lobe of the pituitary gland, but other organs and individual cells can also produce it. This book provides the headlines to follow a course of cumulated knowledge on prolactin research during the last two-three decades and it may also help us understand some of the concerns that we face today.",isbn:null,printIsbn:"978-953-51-0943-3",pdfIsbn:"978-953-51-7073-0",doi:"10.5772/2950",price:119,priceEur:129,priceUsd:155,slug:"prolactin",numberOfPages:246,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"338ea99a4e29b28d7463a976a301711b",bookSignature:"György M. Nagy and Bela E. Toth",publishedDate:"January 23rd 2013",coverURL:"https://cdn.intechopen.com/books/images_new/2575.jpg",numberOfDownloads:41527,numberOfWosCitations:29,numberOfCrossrefCitations:19,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:48,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:96,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"December 1st 2011",dateEndSecondStepPublish:"December 22nd 2011",dateEndThirdStepPublish:"April 30th 2012",dateEndFourthStepPublish:"June 25th 2012",dateEndFifthStepPublish:"July 25th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"145362",title:"Prof.",name:"György M.",middleName:null,surname:"Nagy",slug:"gyorgy-m.-nagy",fullName:"György M. Nagy",profilePictureURL:"https://mts.intechopen.com/storage/users/145362/images/3683_n.jpg",biography:"György M. Nagy, MD, PhD, DSc graduated from the Medical University in Pécs in 1974. He started his work at the Semmelweis University in 1974 at the 2nd Department of Anatomy led by Prof. Béla Halász. He obtained his PhD in Neuroendocrinology in 1992 and his Doctor of Science Degree in 1995. He worked in Birmingham (University of Alabama at Birmingham, USA) as a Research Fellow from 1984 to 1987 in the laboratory of Jimmy D. Neill. He also spent two years (from 1989 till 1991) as a visiting professor in Charleston, SC at the Medical University of South Carolina, USA, in the laboratory of Steve L. Frawley and one year (between 1997-1998) at the Florida State University, Tallahassee, FL, USA in Marc E. Freeman’s laboratory. At present, he is a Professor of The Ross University, Department of Anatomy, Commonwealth of Dominica. His main interests are the hypothalamic regulation of pituitary prolactin secretion and the molecular aspects of the function of mammotrope cells. The title of his best cited article is “Prolactin: Structure, function and regulation of secretion”, written by Freeman ME, Kanyicska B, Lerant A, and Nagy GM (Physiological Reviews 80: 1523-1631, 2000)",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Semmelweis University",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"164305",title:"Dr.",name:"Bela E.",middleName:null,surname:"Toth",slug:"bela-e.-toth",fullName:"Bela E. Toth",profilePictureURL:"https://mts.intechopen.com/storage/users/164305/images/4963_n.jpg",biography:"Bela Ernest Toth Dipl. Eng, MD, PhD started his education with School of Engineering, (Dipl. Eng), graduated as a Medical Doctor (MD), and completed PhD in Neuroscience. He worked as a lecturer for graduate and postgraduate education at Medical School and also at Faculties of Bioengineering and Healthcare Sciences. His scientific background is based on\nuniversity appointments and academic collaborations (Semmelweis University Budapest, Neuroendocrine Research Group Hungarian Academy of Sciences, Rudolph Magnus Institute of Pharmacology, University of Utrecht; Dept. of Molecular and Cell Biology Penn State University, USA; University of Veterinary Sciences, Hungary). Dr. Toth’s research interest on circadian rhythms of PRL secretion started during the university years. He later continued to focus on biology of nutrition, development and regulation of immune cell response, and function of DA in neuroendocrine regulation. Lately, his interests are involving pre-clinical research. 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Hydrogen is a synthetic fuel that can be produced from various raw materials such as water, fossil fuels, and biomass using primary energy sources. During the production phase, there are many alternative production technologies such as steam recovery, waste gas purification, electrolysis, photo processes, thermochemical processes, and radiolysis. Hydrogen has a variety of uses, including nonpolluting vehicles, fuel cells, home heating systems, and aircraft. Furthermore, using hydrogen as an energy carrier is a long-term option for reducing global carbon dioxide emissions by obtaining high-value hydrocarbons through carbon dioxide hydrogenation. The costs of a hydrogen-based system, on the other hand, are still high. Therefore, research on hydrogen, which is abundant in nature, continues so that hydrogen-based systems, particularly for long-term energy storage, can become commercially attractive. The use of hydrogen energy as a complement to traditional energy sources also aids in the implementation of low-carbon solutions.
\r\n\r\n\tThis book invites chapters of research on technologies developed for the production, storage, and industrial applications of hydrogen. Recommendations to overcome challenges such as the high costs of hydrogen energy output, and the policies and promotions of policymakers to bring hydrogen to today's markets will be among the main topics of the book. Studies on the environmental effects of hydrogen energy production, life cycle analyses of methods, and related sustainable development goals will also be included.
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Techniques for the precise synthesis and control of the temporal shape of optical pulses with durations in the picosecond and sub-picosecond regimes have become increasingly important for a wide range of applications in such diverse fields as ultrahigh-bit-rate optical communications (Parmigiani et al., 2006; Petropoulos et al., 2001; Oxenlowe et al., 2007; Otani et al., 2000), nonlinear optics (Parmigiani et al., 2006b), coherent control of atomic and molecular processes (Weiner, 1995) and generation of ultra-wideband RF signals (Lin & Weiner, 2007). To give a few examples, (sub-)picosecond flat-top optical pulses are highly desired for nonlinear optical switching (e.g. for improving the timing-jitter tolerance in ultrahigh-speed optical time domain de-multiplexing (Parmigiani et al., 2006; Petropoulos et al., 2001; Oxenlowe et al., 2007)) as well as for a range of wavelength conversion applications (Otani et al., 2000); high-quality picosecond parabolic pulse shapes are also of great interest, e.g. to achieve ultra-flat self-phase modulation (SPM)-induced spectral broadening in super-continuum generation experiments (Parmigiani et al., 2006 b). For all these applications, the shape of the synthesized pulse needs to be accurately controlled for achieving a minimum intensity error over the temporal region of interest. The most commonly used technique for arbitrary optical pulse shaping is based on spectral amplitude and/or phase linear filtering of the original pulse in the spatial domain; this technique is usually referred to as ‘Fourier-domain pulse shaping’ and has allowed the programmable synthesis of arbitrary waveforms with resolutions better than 100fs (Weiner, 1995). Though extremely powerful and flexible, the inherent experimental complexity of this implementation, which requires the use of very high-quality bulk-optics components (high-quality diffraction gratings, high-resolution spatial light modulators etc.), has motivated research on alternate, simpler solutions for optical pulse shaping. This includes the use of integrated arrayed waveguide gratings (AWGs) (Kurokawa et al., 1997), and fiber gratings (e.g. fiber Bragg gratings (Petropoulos et al., 2001), or long period fiber gratings (Park et al. 2006)). However, AWG-based pulse shapers (Kurokawa et al., 1997) are typically limited to time resolutions above 10ps. The main drawback of the fiber grating approach (Petropoulos et al., 2001; Park et al. 2006) is the lack of programmability: a grating device is designed to realize a single pulse shaping operation over a specific input pulse (of prescribed wavelength and bandwidth) and once the grating is fabricated, these specifications cannot be later modified. Recently, a simple and practical pulse shaping technique using cascaded two-arm interferometers has been reported (Park & Azaña, 2006). This technique can be implemented using widely accessible bulk-optics components and can be easily reconfigured to synthesize a variety of transform-limited temporal shapes of practical interest (e.g. flat-top and triangular pulses) as well as to operate over a wide range of input bandwidths (in the sub-picosecond and picosecond regimes) and center wavelengths. However, this solution presents all the drawbacks due to a free-space solution where it is needful to strictly set the relative time delay inside each interferometer in order to “program” different obtainable pulse shapes. Therefore the pursuit of an integrated (fiber) pulse shaping solution, including full compatibility with waveguide/fiber devices, which can be able to provide the additional functionality of electronic programmability, manifests to be useful for a lot of different application fields. For this reason a programmable fiber-based phase-only spectral filtering setup has been recently introduced (Azaña et al., 2005; Wang & Wada, 2007). In the next section the working principle of this spectral phase-only linear filtering approach is discussed and an improvement of the solution reported in (Azaña et al., 2005) is presented and widely investigated.
\n\t\tA pulse shaper can be easily described in the spectral domain as an amplitude and/or phase filter. Using linear system theory it is possible to consider an input signal
where
Previous solutions are based on amplitude-only filtering (Dai & Yao, 2008), amplitude and phase filtering (Petropoulos et al., 2001; Weiner, 1995; Park et al., 2006; Azaña et al., 2003), or phase-only filtering (Azaña et al., 2005; Wang & Wada, 2007; Weiner et al., 1993). In term of power efficiency phase filtering is preferred since the energy is totally preserved with respect to amplitude only or amplitude and phase filtering where some spectral components are attenuated or canceled. Avoiding any amplitude filtering, in principle we may achieve an energy lossless pulse shaping. Moreover, if only the output temporal intensity profile is targeted, keeping its temporal phase profile unrestricted, a phase-only filtering offers a higher design flexibility, even if obviously it rules out the possibility to obtain a Fourier transform-limited output signal or an output phase equal to the input one. Then, with phase-only filtering we are able to carry out an arbitrary temporal output phase but with a programmable
In this case the system is represented by a phase-only transfer function
The very interesting fiber-based solution for programmable pulse shaping proposed in (Azaña et al., 2005) and used in (Wang & Wada, 2007) is based on time-domain optical phase-only filtering. This method originates from the most famous technique for programmable optical pulse shaping, based on spatial-frequency mapping (Weiner et al., 1993).
\n\t\t\tTransfer function for a pulse shaper.
Spatial-domain approach for shaping of optical pulses using a spatial phase-only mask.
The scheme is shown in Fig. 2: a spatial dispersion is applied by a grating on the input optical pulse, then a phase mask provides a spatial phase modulation and finally a spatial dispersion compensation is given by another grating. Its main drawback consisted in being a free space solution with all the problems related to a needful strict alignment, including significant insertion losses and limited integration with fiber or waveguide optics systems. For these reasons we looked for an all-fiber solution that essentially is a time-domain equivalent (Fig. 3) of the classical spatial-domain pulse shaping technique (Weiner et al., 1993), in which all-fiber temporal dispersion is used instead of spatial dispersion.
\n\t\t\tTo achieve this all-fiber approach we started from a different solution based on the concept concerning a time-frequency mapping using linear dispersive elements (Azaña et al., 2005). As shown in Fig. 3 (top), applying an optical pulse at the input of a first order dispersive medium, we obtain an output signal
Principle of time-frequency mapping for the time-domain pulse shaping approach. β2: first order dispersion coefficient;
To apply the mentioned phase modulation an electro-optic (EO) phase modulator will be used. As it will be more clear afterwards,
Finally, to achieve the inverse Fourier-transform operation on the stretched, phase-modulated pulse, such a pulse is compressed back with a dispersion compensator providing the conjugated dispersion of the first dispersive element (Fig. 4).
\n\t\t\tAs reported in Fig. 4, the binary phase modulation is provided to the EO-phase modulator by a bit pattern generator (BPG) with a maximum bit rate of 20 Gb/s.
\n\t\t\tDispersion mismatch between the two dispersive conjugated elements has a negative effect on the performance of the system and for obtaining good quality pulse profiles it is critical to match these two dispersive elements very precisely. In our work, this was achieved by making use of the same linearly chirped fiber Bragg grating (LC-FBG) acting as pre- and post-dispersive element, operating from each of its two ends, respectively (Fig. 5); this simple strategy allowed us to compensate very precisely not only for the first-order dispersion introduced by the LC-FBG, but also for the present relatively small undesired higher-order dispersion terms.
\n\t\t\tAs reported in Fig. 6, reflection of the LC-FBG acts as a band-pass filter applying at the same time a group delay (GD) versus wavelength that is linear on the reflected bandwidth. In particular the slope of the two graphs of Fig. 6 (left) represents the applied first-order dispersion coefficient, respectively +480 and -480 ps/nm for each of the two ends of the LC-FBG.
\n\t\t\tSchematic of the pulse shaping concept based on time-frequency mapping and exploiting a binary phase-only filtering.
Schematic of the pulse shaping concept based on time-frequency mapping exploiting a single LC-FBG as pre- and post-dispersive medium.
Reflection behavior of the LC-FBG. (left) Group delay over the reflected bandwidth for both the ends; (right) reflected bandwidth of the first end.
Similarly to any linear pulse shaping method, the shortest temporal feature that can be synthesized using this technique is essentially limited by the available input spectrum. On the other hand, the maximum temporal extent of the synthesized output profiles is inversely proportional to the achievable spectral resolution
To find the required binary phase modulation function we implemented a genetic algorithm (GA) (Zeidler et al., 2001). A GA is a search technique used in computing to find exact or approximate solutions to optimization and search problems. GAs are a particular class of evolutionary algorithms that use techniques inspired by evolutionary biology such as inheritance, mutation, selection, and crossover (also called recombination), and they’ve been already exploited for optical pulse shaping applications (Wu & Raymer, 2006). They are implemented as a computer simulation in which a population of abstract representations (called
In our case we use GA to find a convergent solution for phase codes corresponding to desired output intensity profiles (targets), starting from an input spectrum nearly Fourier transform-limited. First we code each spectral pixel with ‘0’ or ‘1’ according to the phase value (
The fitness of each chromosome is indicated by its corresponding
while the
Flow chart of the applied optimization technique.
During each iteration, thanks to GA we move in a direction that reduces the total cost function. This way we derived the particular phase code so as to obtain the desired output temporal intensity profile, whose deviation from the target hopefully is within an acceptable limit. After a sufficient number of iterations, the obtained phase profile can be then transferred to the experiment. In Fig. 7 the flow chart for a general optimization technique is shown. In our case within the block where we calculate the new array of transfer functions
To better understand what a cost function is, we report here a couple of examples concerning the cost functions used for single flat-top pulse and pulsed-burst generations. In Fig. 8 (left) the features taken into account for a flat-top pulse generation are shown. Since the generated signal is symmetric in the time domain, we considered just the right half of the output profile.
\n\t\t\t\tThree time intervals correspond to three cost functions: the first one (
left) Cost functions for a single flat-top pulse generation. (right) Features taken into account with cost functions for a pulsed-burst generation.
Simulated and target profiles for a flat-top pulse (a) and a 5-pulses sequence (b). The used phase codes are shown in the insets (solid) together with the input pulse spectrum (dashed).
In Fig. 8 (right) another example considering a pulsed-burst as target shows the considered features: the intra-pulse amplitude fluctuations, the timing fluctuations and the pedestal amplitude again. In particular, Fig. 9(b) shows the comparison between the simulated temporal profile and its relative theoretical target for the case of a 5-pulses sequence. In this case, even though we weighted the partial cost functions in order to obtain a sequence with flat-top envelope, because of the limited spectral resolution, the simulated sequence is not so equalized (inter-pulse amplitude fluctuations ≈ 25%) as the theoretical target.
\n\t\t\t\tTo demonstrate the programmability of the proposed scheme, we targeted shapes like flat-top, triangular and bursts of 2, 3, 4 and 5 pulses with nearly flat-top envelopes, defining a specific total cost function for each case.
\n\t\t\tAs shown in the experimental setup in Fig. 10, the exploited optical pulse source was an actively mode-locked fiber laser producing nearly transform-limited ~ 3.5 ps (FWHM) Gaussian-like pulses with a repetition rate of 10 GHz, spectrally centered at λ0 = 1542.4 nm. The source repetition rate was decreased down to 625 MHz, corresponding to a period of 1.6 ns, using a Mach-Zehnder amplitude modulator (MZM) and a bit pattern generator (BPG 1) producing a binary string with a logic “1” followed by fifteen logic “0”.
\n\t\t\t\tExperimental setup of the programmable all-fiber pulse shaper.
In order to temporally stretch the optical pulses, they were reflected in a LC-FBG, incorporated in a tunable mechanical rotator for fiber bending, which allowed us to tune the chromatic dispersion coefficient by changing the stretching angle
Referring to (Kim et al. 2004), a method to achieve tunable chromatic dispersion compensation without a center wavelength shift is based on the systematic bending technique along a linearly chirped fiber Bragg grating (LC-FBG). The bending curvature along the LC-FBG corresponding to the rotation angle of a pivots system can effectively control the chromatic dispersion value of the LC-FBG within its bandwidth. The group delay can be linearly controlled by the induction of the linear strain gradient with the proposed method. Based on the proposed method, the chromatic dispersion could be controlled in a range typically from ~100 to more than 1300 ps/nm with a shift of the grating center wavelength less than 0.03 nm over the dispersion tuning range.
\n\t\t\t\t\tIn our particular case, to “write” the LC-FBG prototype exploited in the experiment presented in Section 2.2, we used a setup where a UV laser with a wavelength of 244 nm was employed. Its light beam was deflected by a sequence of mirrors; the last mirror was fixed on a mechanical arm, whose position was automatically driven by a proper LabView software, so as to hit a phase mask. Such a mask divided the input beam in two coherent beams so as to create interference fringes through beating. Such fringes had the task to photo-expose the span of fiber in order to realize the LC-FBG. In this case the linear chirp (periodicity linearly increasing/decreasing along the fiber) was directly introduced by the phase mask.
\n\t\t\t\t\tIn Fig. 11 the measured reflection spectrum and the group delay (GD) of a typical LC-FBG are reported, showing excellent results in terms of amplitude ripples (< 0.5dB) (Fig. 11(a)) and linear behavior of the GD versus wavelength (Fig. 11(b)). The main difference between the LC-FBG described in this section and the one employed in Section 2.2 is the central wavelength (1542.4 nm instead of 1550.4 nm).
\n\t\t\t\t\ta) Reflection spectrum of a typical LC-FBG. (b) GD of the same LC-FBG.
The LC-FBG was carefully attached to the cantilever beam fixed on the rotation stage in order to compose the dispersion-tuning device (Kim et al. 2004). Through the device a certain tunable bending angle is applied on the metal beam where the grating is attached. Both the bandwidth and the chromatic dispersion value (the derivative of the graph in Fig. 11(b)) of the grating change with the bending angle applied to the grating. In particular, increasing the rotation angle it is possible to decrease the chromatic dispersion and to increase the reflection bandwidth.
\n\t\t\t\t\tIn Fig. 12(a),(c) variation of reflection spectra with the rotation angle are shown, whereas in Fig. 12(b),(d) variation of GD with the rotation angle are reported. As shown in Fig. 12(a),(c), the central wavelength of the reflection bandwidth is fixed and equal to ~1550.4 nm. In Fig. 13 variation of the chromatic dispersion (left) and the -3dB-bandwidth (right) with the rotation angle are reported.
\n\t\t\t\t\tMeasured results of the variation of (a),(c) the reflection spectra and (b),(d) the group delay of the tunable dispersion compensator with the rotation angle.
Variation of chromatic dispersion (left) and -3dB-bandwidth (right) of the tunable dispersion compensator with the rotation angle.
Concluding, in the example reported in this section a LC-FBG has been fabricated through a proper setup and it has been employed with a mechanical rotator in order to compose an all-fiber tunable chromatic dispersion compensator able to provide a chromatic dispersion in the range (±134.4;±1320.4) ps/nm. The sign of the applied chromatic dispersion depends on which end of the grating we employ. Furthermore, adding a circulator on an end of the LC-FBG, we obtain a system where port 1 and port 3 of the circulator represents the input and the output of the tunable dispersion compensator respectively (Fig. 14).
\n\t\t\t\t\tTunable chromatic dispersion compensator scheme. From input 1/output 1 a positive chromatic dispersion is provided whereas from input 2/output 2 a negative chromatic dispersion is provided.
The capabilities of our programmable picosecond pulse re-shaping system were first demonstrated synthesizing the flat-top optical pulse related to Fig. 9(a) and the 5-pulses sequence related to Fig. 9(b), monitoring the temporal profile of the output signal through a commercial autocorrelator (Fig. 15), then the experiment has been repeated monitoring the output optical signal by an optical sampler.
\n\t\t\t\tExperimental and simulated autocorrelation curves for the flat-top pulse (a) and the 5-pulses sequence (b).
In particular we synthesized five different temporal waveforms of practical interest (Petropoulos et al., 2001; Park et al., 2006; Azaña et al., 2003) (see Fig. 16), namely a 9-ps (FWHM) flat-top optical pulse (Fig. 16(a)), a 8.5-ps (FWHM) triangular pulse (Fig. 16(b)), and three pulse sequences with flat-top envelopes, respectively a “11” (Fig. 16(c)), a “111” (Fig. 16(d)) and a “101” (Fig. 16(e)) sequence, with ~ 20-ps bit spacing.
\n\t\t\t\tTarget and experimental profiles for a flat-top pulse (a), a triangular pulse (b), a “11” sequence (c), a “111” sequence (d) and a “101” sequence. The respective used phase codes are shown on the right (solid) together with the input pulse spectrum (dashed).
\n\t\t\t\t\tFig. 16 shows the traces of the five synthesized pulse shapes experimentally acquired by the optical sampler in comparison with the simulated pulse shapes (the required binary codes to synthesize each of the target shapes are shown on the right of each graph), showing an excellent agreement between theory and experiments in all cases. Based on the values of the temporal pixel (the bit period of the BPG 2 was
To show the behavior of the system working on targets with a temporal extent larger than the above mentioned maximum, in Fig. 17 we report the comparison between simulated targets and experimental output temporal profiles acquired by the optical sampler, for cases with a temporal extent larger than 80 ps. In the first case (Fig. 17(a)) even though the agreement between simulation and experiment is quite good by the amplitude peaks of the target, the pulse shaper is not able to maintain the pedestal amplitude within an acceptable level, especially by the logic “0”s of the sequence. Moreover, in the target of the sequence “1001” two side residual peaks are already present due to a limited spectral resolution.
\n\t\t\t\tTarget and experimental profiles for a “1001” sequence (a), a “1111” sequence with an equalized target (b) and a “1111” sequence with a non-equalized target (c).
This limitation is due to the limited chromatic dispersion imposed by the LC-FBG (with a dispersion more than 480 ps/nm the reflection bandwidth would be narrower than the input signal bandwidth giving rise to unacceptable distortions on the output signal) and to the bit rate of the BPG 2 (20 Gb/s is the maximum value).
\n\t\t\t\tIf we consider all the features mentioned in Section 2.1 about a pulsed-burst (acceptable pulses amplitude fluctuations, timing fluctuations, pedestal amplitude), having a look on Fig. 17(b)-(c) it is possible to notice bad performances in particular for the equalization and the pedestal level of the pulsed sequence. Moreover, the mismatch between simulated targets and experimental results increased if compared with all the cases shown in Fig. 16, confirming the non-correct working condition.
\n\t\t\t\tConsidering the frequency bandwidth of the output pulses from the pulse shaper (FWHM ≈ 4.5 ps corresponding to a bandwidth ≈ 222 GHz), the reported setup provided a fairly high time-bandwidth product > 16.
\n\t\t\t\tAs indicated by Eq. 4, a higher spectral resolution (i.e. longer temporal extension for the synthesized waveforms) can be achieved by increasing the bit rate of BPG 2 or by use of a higher dispersion. Using a higher dispersion would however require to decrease the repetition rate of the generated output pulses (assuming the same input pulse bandwidth). Other experimental non-idealities affecting the system performance include spectral fluctuations of the input spectrum, the non-perfect squared shape of the electric binary code produced by the BPG 2 and undesired higher order dispersion terms introduced by the LC-FBG.
\n\t\t\tIn conclusion, we have demonstrated a fiber-based time-domain linear binary phase-only filtering system enabling arbitrary temporal re-shaping of picosecond optical pulses. Flat-top and triangular pulses together with two and three pulse-bursts have been synthesized from the same input pulse by properly programming the bit pattern code driving an EO phase modulator.
\n\t\tMineral nutrition is an indispensible part of animal feeding system which ensures optimum health, production, and reproduction in animals and birds. Even though, required in small quantities as compared to other nutrients such as energy and protein, their deficiency and imbalances are promptly reflected in the changes of animal wellbeing and their production. Sometimes, this may also cost the animals with their lives. They are essential for maintaining the normal health and productions; whereas in some cases additional supplementation could yield better growth and egg production. The significance of mineral nutrition is well documented and still new projects are undertaken to understand, explore better aspects and validate newer postulates associated in the field of mineral nutrition.
Conventionally, minerals are used in the diets through their inorganic salts, but low bioavailability of inorganic mineral salts necessitates using at higher doses in order to meet the animal requirements, which indirectly creates more pollution with minerals [1]. Recently, nano-sized minerals are considered to have greater bioavailability in animals and birds due to increased surface area, which tend to produce better desirable responses [2]. This chapter discusses synthesis of different nano-minerals, their mechanism of action, poultry performance, tissue retention, immunity, antioxidant activity and antimicrobial actions compared with their conventional mineral sources.
Minerals are vital for all biochemical functions in the body along with providing structural supports, electrolyte balance and homeostasis. The requirements of calcium (Ca) and phosphorus (P) in animals and poultry are comparatively greater than other minerals. They are mainly needed for bone development [3]. Zinc (Zn) is essential for several physiological and biochemical processes such as normal growth, reproduction, wound healing, ossification, DNA synthesis, cell division and gene expression, photochemical processes of vision, and augmenting the immune system of the body through lymphocyte replication and antibody production [1, 2, 3, 4]. Selenium (Se) is essential for optimum animal production, fertility, and disease prevention [3]. However, role of Se in intra- and extra-cellular antioxidant systems is vividly recognized [5], which, as a component of glutathione peroxidase (GPx) neutralizes hydrogen and lipid hydroperoxide and thus maintains membrane integrity and guards from oxidative damage of lipid membranes [1]. Copper (Cu) is essential for normal growth, bone development, immune response, foetal development, nerve functioning, and in antioxidant system as a part or a cofactor of several enzymes [1]. Manganese (Mn) is an essential trace mineral necessary for optimum antioxidant, immune system as well as a component on several important enzymes [2]. Likewise, iron (Fe) is needed for synthesis of hemoglobin, which transports oxygen in the body and myoglobin, and is also associated with enzymes, e.g., peroxidases, hydroxylases, and catalase. Chromium (Cr) is a component of glucose tolerance factor and is essential for maintaining immune and antioxidant function and metabolism of lipids and proteins [6]. Combining all the effects together, minerals are associated with all the physiological functions in the body either involved directly or indirectly. Hence, a diet balanced in all the minerals is always a matter to maximize the productivity and health of the animals.
The minerals are present in all the food and feed sources as an integral part, but the amount required to support the productivity is not met through the feed resources. Added to this, the mineral component from plants are less absorbed and retained in the body as they form complex compounds with other components. For an instance, plant ingredients in the diets contain large amounts of unavailable P as phytates, which accounts almost 60–80% of total P and are not absorbed by the birds due to insufficiency of phytase enzyme [7]. Again, the bioavailability of minerals from traditional inorganic sources is relatively less for many minerals, while the requirements for high producing animals and birds are very high [8]. This necessitates the addition of minerals in the diets from extraneous sources [1, 9, 10], which gives the concepts of minerals as feed supplements in animal and poultry rearing. Minerals are generally supplemented in higher concentrations than their actual needs at cellular levels when inorganic supplements are added due to their poor bioavailability [11] along with chemical antagonism and interactions with other nutrients [12]. Conventionally, minerals are supplemented in the diets in their inorganic salts — oxides, sulphates, or carbonates — for instance, Zn oxide, Zn sulphate, sodium selenite, Ca carbonate, and dicalcium phosphate (DCP). The low bioavailable inorganic mineral salts supplemented at higher doses in order to meet the animal requirements, indirectly creates more pollution with minerals [1, 9, 10]. This issues needs to be addressed and better bioavailable mineral sources are a thrust of mineral studies for many decades. Many organic chelated minerals have been tried to fill the gap and reports indicated mixed responses considering their bioavailability, cost effectiveness and biological responses. Organic minerals as proteinate supplemented retained better in poultry signified better bioavailability as compared to their inorganic counterparts [13, 14]. Organic mineral supplementation has shown varied type of response in layers. For example, Rajendran et al. [15] reported improvement in laying percentage of birds, whereas Soni et al. [16] did not observed any effect on egg production by feeding organic minerals. In spite of better bioavailability of organic minerals over their inorganic counterparts, these sources are less used due to their higher cost [17]. This necessitates the urgent requirement for better bioavailable sources to be used particularly in poultry production to save guard the environment without affecting the animal or bird productivity at a cost effective manner.
Recently, nano-sized minerals are considered as a potential alternate to fill the gap and they have been tried and tested in many ways to validate their better bioavailability in diversified animals and birds. Nanotechnology confers the materials with particle size in nanometer (nm) range (<100 nm) at least in one direction, and by virtue of the nano-sized particle (NP), their structures exhibit significantly novel physical, chemical, and biological properties and functionality [18]. Due to their small size, the surface area increases many folds and thus they tend to produce many desirable responses [2]. The altered chemical and physical properties of NP could potentially modify the biological responses compared to its bulk materials [2, 19]. Studies have been carried out across the globe to unveil more beneficial effects as a feed additive in animals and birds, but still nanotechnology is in its infancy in the animal husbandry sector. In this chapter, we have tried to compile the various effects of the nano-minerals and other nano-materials in poultry.
Nanotechnology deals with research and development related to nano-sized materials, and are specifically focused at understanding of measurement and manipulation of matters at the nanoscales. Use of NP is gaining importance in diversified disciplines starting from medicine, environment, food, electronics, pharmaceutical applications, biotechnology, agriculture, and animal science [2]. Nano-minerals are specially synthesized mineral particles with its particle size ranging from 1 to 100 nm [20]. Like NP, nano-minerals possess higher physical activity and chemical neutrality, which may be a reason for efficient absorption in the animal system [21] and are reported to be stable under high temperature and pressure [22] as well. Nano-minerals as feed supplement can increase the feed efficiency, diminishing feed cost by reducing the supplemental doses, and simultaneously intensifying the yield and value of animal products by virtue of their superior bioavailability [1, 23, 24]. For example, nanominerals, due to their smaller size, were reported to be easily taken up by the gastrointestinal tract and efficiently utilized in vivo, and hence were more effective than the larger sized zinc oxide (ZnO) at lower doses [20]. Moreover, nanominerals exhibit lesser adverse effects as compared to their conventional counterparts. For instance, Reddy et al. [25] reported that nano-ZnO had less adverse effect on human cells. Nanominerals can cross the small intestine and further distribute into the blood, brain, and other different organs [26]. The functional properties of nanominerals, such as chemical, catalytic or biological effects, are highly influenced by their particle size, shape, composition, crystalline structure, surface ions, and morphology [27, 28, 29]. Nano minerals can be synthesized by physical, chemical or biological methods (Figure 1) [1, 19]. In physical method, physical forces are used to break down the larger sized materials to nanoscale, whereas in chemical method, reducing agents are used to reduce the particle size. Nanomaterials produced from physical method have wide range of particle size, but chemical method produce tentatively uniform particle size [19]. In biological method, also called green synthesis, different plant products or cultures are used for reducing the size of the intended materials. This method is free from use of corrosive chemicals which is the main constraint in chemical synthesis of NP. However, maintaining the culture needs technical expertise and is considered as a limitation in this method. Considering all points and methods, for use in livestock and poultry feeding, chemical method seems preferred as they are cheap, easy to produce and do not require any special instrument and expertise [19].
Different methods of nano-minerals synthesis.
Nanoparticles are quite different in physical properties from bulk materials, contributing to wide range of new applications. Due to the much-reduced particle size they exhibit novel and improved physical, chemical, and biological activity that do not necessarily resemble the bulk mineral counterpart, and thus numerous modes of action are postulated by different workers. We have tried to compile the available resources keeping poultry nutrition in view. As such, further studies are warranted to establish or abolish any mechanism of action postulated till date.
Possibly the increased surface area of NP facilitates better interaction in biological interface and their increased retention time in the gut, reduced influence of intestinal clearance mechanisms and effective delivery of functional compounds to target sites result in better bioavailability and functionality [30]. By virtue of their small size, uptake by the gastrointestinal epithelium is much easier [20]. Uptake of NP through mucosal layer is dependent upon the charge on their surface and pH of adjacent environment. Changes in pH alter the surface charge and thus lead to agglomeration and change in size [31, 32]. For example, cationic NP was reported to be trapped within the glycosylated areas of mucin, whereas the diffusion of carboxylated anionic microparticles through the epithelial surface was better [33]. Nanoparticles are either absorbed through epithelial villi into the circulation and are subsequently transported to the liver and spleen [20, 34] or through M-cells in the Peyer’s patches crossing the enterocytes and pass into the hepatic circulation [35]. Due to the smaller pore size (0.6 to 5 nm) of tight junctions, paracellular transport of NP is usually limited under normal physiological conditions [36]. Trace element NP may decrease mineral antagonisms in the intestine leading to enhanced absorption and utilization, thereby lowering their excretion into the environment. They are chiefly transported by transcellular mechanism. After absorption, their dispersion, breakdown, and discharge are related to their dissolvability, charge, and size. Nano-minerals have the potential to enter the blood, brain, lung, heart, kidney, spleen, liver, intestine and stomach after crossing the small intestine [26]. But their uptake rate in intestinal epithelia and other body tissues substantially differs [37]. The particle sizes less than 300 nm can reach to the blood circulation, whereas particles smaller than 100 nm can penetrate various tissues and organs [38].
The amount of mineral absorbed and retained is termed as bio-availability, and this can be reflected by improved performance of animals or birds. Better bioavailability is indicated by more amount of mineral deposits in the organ, serum, and also better biological responses, and is affected by factors that influence absorption such as concentration, chemical forms, transport pathway, nutrient-nutrient interactions and excretory losses. Reports suggest that the bioavailability of inorganic salts is less, which results in high excretion of minerals into the environment through urine and feces [39]. Considering the other potential replacement of inorganic salts, organic and nano-minerals have provided encouraging biological effects when fed to animals and birds [1, 8, 21, 40, 41] with certain limitations.
Of the different mechanisms of transportation through intestinal epithelium, paracellular transport involves passage of substances across the epithelium through the intercellular spaces whereas transcellular transport involves passage of substances through the cells [42, 43]. Paracellular transport does not include any transporter or energy expenditure for transport and the absorption occurs along the concentration gradient, thus is not very efficient [42]. Tight junctions act as gatekeeper of paracellular transport and they exclude entry of macromolecules [42, 43]. Transcellular absorption involves either diffusion across concentration gradient or active carrier mediated transportation utilizing energy or through endocytosis [42]. Intestinal absorption can be improved by altering paracellular and transcellular transport. Compared with CuSO4 and CuO microparticles, CuO NP are believed to be rapidly transported into cells, and subsequently interact with the Cu transport proteins [44], with a non-antagonism of CuO NP with Zn. Na et al. [45] suggested the possibility that CuO NP are absorbed through a different pathway that other Cu sources use [1].
Liver handles most of the absorbed nutrients and regulates their release into blood circulation for further distribution in different tissues or excretion. Hence, increased concentration in liver is a suitable indicator of retention status. The minerals supplemented in their NP forms increase their bioavailability and utilization efficiency [46]. Minerals supplemented in their nano-forms retained better in in vivo studies as compared to their inorganic salts [41, 47, 48]. Patra and Lalhriatpuii [1] extensively reviewed the retention of nano mineral supplementation in poultry and suggested that Ca, P, Zn, Cu, Se, Mn and Fe in their nanoforms are retained better than their inorganic counterpart. Owing to better bioavailablity, Ca and P supplementation as nanominerals reduces the quantity of supplementation, thus making the ration economic and environment friendly [1]. Sohair et al. [49] reported that the use of hydroxyapatite NP is economically efficient as compared to the control diets. Nano-Zn in lower dose could be a good substitution in mineral premix instead of ZnO, which tend to improve carcass characteristics and oxidative stability of chicken meat [50]. Hu et al. [51] studied the selenium retention from nano-Se and selenite origins in chickens by the intravenous or oral administration of the radio labeled 75Se and the in vivo ligated intestinal loop procedure, and reported higher nano-Se retention in the whole body and liver tissue compared to that of selenite, and intestinal transport of Se through ligated intestinal lumen loop to body was higher than that of selenite. Retention of Se is found to be influenced by the dietary Se source and concentration of Se supplemented as well. Reports suggests nano-Se supplementation to Guangxi Yellow broilers diet improved hepatic and muscle Se contents in a dose dependent manner up to a supplemental dose of 0.3 mg/kg [52], suggesting a relationship between nano-Se metabolism and liver function. Similar responses were also reported by Meng et al. [53] and Mohapatra et al. [54], where they obtained higher Se deposition efficiency in nano-Se supplementation groups than sodium selenite group, which also suggests better retention of nano-Se than that of sodium selenite as suggested by Zhang et al. [55]. Radwan et al. [56] observed higher Se content in eggs by nano-Se supplementation as compared to sodium selenite, most probably due to the faster transfer of nano-Se into the egg. A linear and quadratic increase in liver and muscle Se in a proportionally to the dietary nano-Se level, with a the peak value at 2.0 mg/kg of dietary nano-Se was reported; however, considering meat quality, immune function, oxidation resistance, 0.3 to 0.5 mg/kg was reported to be the optimum level of supplementation of nano-Se for broilers [57]. Supplemental nano-Cr picolinate at 0.5 and 3 mg/kg of Cr increased Cr and Ca concentration in the liver and egg, and improved Zn and Mn retention in layer chickens [58]. Nano-Cr added at 0.4 mg/kg feed was found to increase the retention of Cr, Ca, P, Zn, and Fe in layers, increased the Cr and Zn concentration in plasma, liver, and eggshell; zinc in egg yolk; Ca in the liver and eggshell [59]. However, no increase in Cr content in the eggs and blood of Japanese quails was reported due to dietary addition of 0.2 to 0.8 mg/kg of nano-Cr [60]. Jankowski et al. [61] reported no effect of reducing Mn from 100 to 50 or 10 mg/kg either from NP-Mn2O3 or MnO on the growth performance or oxidation process in liver and breast muscles and increased Mn accumulation and reduced Zn and Cu accumulation in the liver, breast muscle and skin but increased intestinal absorption of Zn. Nano MnSO4 supplementation resulted in improvement of tibia bone characteristics such as tibia length, tibia volume, tibia breaking strength, tibia diameter and bone weight [1]. Intramuscular injection of Fe-NP at 2 mg/kg BW improved body weight gain, hematological traits, and tissue retention of Fe in broiler chickens [62]. The enrichment of the food with nano-Fe improved Fe concentration in the body (by 5.3%) and erythrocyte in blood [63]. Cysteine-coated Fe3O4 NP at 1.2 mg/kg diet recorded similar weight gain, feed efficiency, hematological and biochemical parameter as that of 120 mg/kg of FeSO4 in a quail diet [64]. Overall, the above observations suggest that different mineral NP usually increased retention of minerals in tissues, eggs and meat even at the lower doses compared with their conventional sources of minerals.
Most of the studies on poultry has emphasized on growth promoting effect as well as mineral retention due to supplementation of nanoforms of minerals (Figure 2). Studies have shown growth promoting effects by feeding nano-Zn [48, 50, 65, 66], nano-Se [52, 54, 67], nano-Ca [49, 68, 69] and nano-Ag [70]. Mohammadi et al. [71] observed improved growth performance in broilers supplemented with nano-Zn-methionine and nano-Zn-max at 80 mg/kg of diet; however, dietary nano-Zn sulphate reduced growth performance in broilers. Nano-Ag supplementation at 4 mg/kg caused an improved body weight gain and best feed conversion ratio in broiler [70]. Silver acting as an antimicrobial agent on intestinal harmful bacteria may improve gut health leading to better nutrient absorption, which was manifested by improved weight gain, feed intake and feed conversion ratio of broilers fed diets containing Ag NP [72]. Nano-Ca phosphate at 50% level of recommended supplementation resulted in improved body weight gain without altering feed conversion ratio, carcass characteristics and biochemical parameters similar to the 100% DCP supplemented group [73].
Different beneficial biological effects of nano-minerals in poultry.
Supplementation of DCP NP has been reported to show better feed conversion ratio and body weight gain in poultry at 50% levels [68] and at 1.75, 1.31, and 0.88% levels [69] when compared to the control groups fed with larger DCP particles. Similar to DCP NP, hydroxyapatite NP also increased growth rate and feed intake in broilers at 2 to10% supplementation [49] without affecting the digestibility coefficient of other nutrients. However, Sohair et al. [49] observed that supplementation of 0.12% of calcium phosphate-NP instead of the conventional DCP at 2% resulted in better body weight gain, feed efficiency and economic efficiency in broiler chickens. Mishra et al. [48] fed layer birds with extremely low levels of nano-Zn (1/500th of basal dose) and obtained similar growth promoting effect. Likewise, Ahmadi et al. [65] observed increased body weight gain, feed intake, and feed efficiency at 60 and 90 mg/kg diet of ZnO NP, but exhibited a lower performance in chickens at a dose of 120 mg/kg diet, whereas Fathi [66] reported lower feed efficiency in birds by supplementing nano-ZnO at 40 mg/kg. In contrast, feed intake, body weight gain, feed efficiency and, carcass traits were not affected due to supplementation of nano-ZnO at 25 and 50 mg/kg as well as ZnO at 100 mg/kg [50]. Nano-Zn at 80 mg/kg increased Zn, Ca and P levels, bone dimensions, weight, total ash along with higher liver and muscle Zn concentration [74]. Significantly lower fat and cholesterol content and better antioxidant status was obtained by supplementation of nano-Zn than inorganic Zn at 80 mg/kg [74]. Nano-ZnO increased mRNA expressions of insulin like growth factor-1 and growth hormone genes in broiler chickens compared to the inorganic or organic Zn [75].
Nano-Cr increased protein contents in thigh and breast muscles and lowered fat and cholesterol concentrations in thigh muscles. Chromium NP at 0.5 mg/kg diet improved breast and thigh muscle protein content, average daily gain and feed efficiency and lowered cholesterol and fat in thigh muscles of the broilers [76]. However, supplemental nano-Cr picolinate at 0.5 and 3 mg/kg [58] or 0.4 mg/kg [59] of Cr did not affect body weight, feed intake, feed efficiency, and egg production of layer birds. Supplementation of nano-Cr at 0.8 mg/kg diet was effective in reducing the negative effects of induced stress on meat quality of quail broilers, as evident from reduced malondialdehyde concentration in the thigh muscle and unaltered hematological parameters [77]. CuO NP was more efficient in increasing growth performance and immunity compared with the conventional sources of Cu [78]. As compared to the inorganic salts, supplementation of nano-Se improved the body weight gain and lowered the feed to gain ratio at doses up to 0.30 mg/kg diet, beyond which no beneficial effect was recorded [52, 54]. Se-yeast and nano-Se resulted in better growth performance than sodium selenite at 0.2 mg/kg Se [79]. Nano-Se supplementation reduced drip loss percentage without altering weight gain, feed intake, and feed conversion, meat color or immune organ index (thymus, bursa, and spleen) in broilers [57]. However, Se supplementation irrespective of its source (sodium selenite or nano-Se) increased daily weight gain and feed efficiency [67], though nano-Se proved to be more efficient. Improved weight gain and feed conversion due to supplementation of Fe NP (7 mg/kg) was possibly due to increased arginine in liver [80]. Dietary Fe sulfate NP resulted in highest jejunal villi width and surface area in broiler chickens at 21 and 42 days of age [81]. Overall, above studies that nano-minerals at reduced dose rates have potential to improve growth performance and the quality of meat compared with the conventional mineral sources.
Eggs and meat are the primary products of poultry industry which are widely accepted, consumed and provides the quality nutritional security to the human race. The huge demand of poultry products intensifies the production system and improving the productivity becomes the major focus of research. The composition and nutrient density of poultry diets affect composition and nutritional quality of eggs and their products [82]. Considering the layer birds, precise mineral nutrition is very important to maintain the egg production and egg production is very susceptible to minute deficiency of many minerals. Several studies have been conducted to validate the effects of nanominerals in layers and their effects on egg productions are documented.
Calcium is required for egg shell formation; hence its requirement in layer diets is very high to sustain egg production. On adding 1 g/L of Ca carbonate NP in water, Wang et al. [83] could find stronger eggshell strength and better freshness indexed eggs as compared to the control. However, Ganjigohari et al. [84] reported a drop in egg production percentage, egg mass and low blood Ca level by reducing 4.03% of Ca carbonate by 0.126% Ca carbonate NP in laying hens as compared to birds supplemented with 4.03% of Ca carbonate replaced by 2.02%, 1.01%, 0.25% Ca carbonate NP, which would be due to too much reduction in the Ca level in the bird’s diet. Similarly, Zn supplementation is obligatory to improve egg production and quality [1]. Being a part of enzyme carbonic anhydrase, Zn is required during egg shell formation and thus deficiency of Zn results in poor eggshell quality. Zn also interrelate Ca crystals during eggshell synthesis [85] which indirectly affects formation of shell membrane and eggshell. Abedini et al. [85] reported an improvement in feed intake, egg mass, egg Haugh unit, eggshell thickness and strength, and tibia ash content and strength at 40 and 80 mg Zn/kg diet as ZnO NP in the laying hens. Tsai et al. [86] observed a hike in Zn retention, thickness of the eggshell, concentration of growth hormone in the blood serum and carbonic anhydrase in nano-Zn supplemented groups as compared to control, without affecting the immunity and other nutrient retention in birds. However, no effect of different dietary Zn sources such as inorganic, organic or nano-Zn on egg quality parameters namely, egg mass, eggshell weight, and eggshell breaking strength [87, 88]. An increase in Zn content in egg yolk due to supplementation of nano-Zn may be proved advantageous to produce designer egg and aid in better keeping quality [82]. Olgun and Yildiz [89] observed highest egg weight and the lowest eggshell thickness by supplementation of nano Zn at 50, 75 and 100 mg per kg diet as compared to Zn-sulphate and Zn-oxide and Zn-glycine supplemented birds and thus, suggested nano-Zn supplementation negatively affects the eggshell thickness and bone mechanical properties. However other studies reported positive responses by supplementation on nano-Zn [82, 85]. The malondialdehyde content in egg was reduced in the groups supplemented with Zn-oxide NP at 80 mg Zn/kg diet [87] and 40 mg/kg of Zn-oxide NP [66], respectively. Dietary Se has a significant role in egg production and immunity in poultry and reports suggests better responses of nano-Se as compared to its conventional counterparts. Radwan et al. [56] reported that use of nano-Se improved Se content in eggs, egg production and feed conversion ratio without affecting egg weight, feed intake in birds. Qu et al. [90] supplemented Se-NP at 0.5 mg/kg diet in laying hens and reported improved rate of egg production, glutathione peroxidase (GPx) activity, total antioxidant status, along with decreased soft-shelled or cracked egg rate. Meng et al. [53] observed an increase in egg Se concentration by supplementation of Nano-Se at 0.3 mg/kg as compared to sodium selenite, Se-yeast. However, they observed that Se-yeast and nano-Se were better retained in the body than sodium selenite. It is observed that injection of nano-Se and nano-ZnO lessened the negative effects of heat stress by increasing antioxidant activity and reducing oxidative stress [91]. Shokraneh et al. [91] observed increased activity of GPx and superoxide dismutase (SOD) and total protein and decreased the levels of corticosterone, cortisol, T4 and T3 in the eggs being injected with NaCl solution containing 40 μg nano-Se at high eggshell temperature. In ovo injection of Cu-NP on 1st and 10th day of incubation showed decreased oxygen consumption, lower heat production, higher residual yolk sac weight compared with the control group, signifying reduced lipid oxidation in Cu-NP injected group [92]. Supplementation of nano-Cu in poultry has shown varied effects depending on dose administered. For an instance, in ovo supplementation of nano-Cu and Cu-sulphate NP at 50 mg hiked the red blood cells and white blood cells in poultry [93], while at a dose of 0.3 mL containing 50 mg/L nano-Cu improved the expression of pro-angiogenic and pro-proliferative genes [94], and also improved the bone characteristics at 42 days birds which signified the possible effect of nano-Cu in bone development and maintenance [95]. The better performances in poultry by in ovo injection of nano-Cu was attributed to improved metabolic rate during embryogenesis resulting in amplified performance of broiler chickens after hatching [96]. Supplemental nano-Cr-picolinate at 0.5 and 3 mg/kg of Cr improved egg quality, retention of Cr and Zn, whereas, it decreased shell ratio in the 60th day eggs [58]. Nano-Cr supplementation at 0.4 mg/kg of feed also improved egg quality parameters including Cr and Zn content in eggshell, Ca in the liver and eggshell, and Zn in egg yolk [59]. Another study specified that eggs of birds supplemented with nano-Cr at 0.2 and 0.4 mg/kg feed exhibited higher shell strength than eggs of hens from the group control and receiving Cr in an inorganic form [97]. In ovo supplementation of nano-Fe though improved body weight gain to egg ratio and feed conversions ratio at 7 days of age in broiler chicks, but no such improvement was observed later and there was no significant effect on hematological parameters [98]. L-cysteine-coated Fe-oxide NP at 6 or 60 mg/kg diet improved availability and utilization of Fe as evident from increased percentage of egg production and egg weight in quails [99]. Taken together, nano-minerals can improve egg production and s eggs quality traits at decreased rate of application.
Trace minerals particularly Zn, Se, Cu, and Mn play a major role in anti-oxidant system, either being a component of the antioxidant metallo-enzymes or indirectly by regulating their activities. These enzymes act an indicator of the wellbeing of the animals and they increase or decrease depending on the mineral level in the animal or birds. Hence, better bioavailability of a mineral source can be determined by monitoring these enzyme levels which are mineral specific. Different mineral NP have been shown to improve antioxidant status in birds compared to their conventional forms (Figure 3). Supplementation of ZnO-NP at 40 and 80 mg/kg in the diet of broiler chickens augmented their antioxidant status as evidenced from increased activity of SOD and catalase, and decreased concentration of malondialdehyde [100]. Zhao et al. [17] observed higher total antioxidant activity in serum and liver tissue, serum catalase activity and reduced serum and liver malondialdehyde concentration in the 20 mg/kg nano-ZnO group of broiler chickens compared to the control (60 mg/kg ZnO) chickens. Zhao et al. [17] also reported higher activity of serum and liver Cu-Zn-related SOD and serum catalase in the diets containing 60 and 100 mg Zn/kg from ZnO NP. Bami et al. [50] reported that ZnO NP at 25 and 50 mg/kg as well as conventional ZnO at 100 mg/kg did not affect feed intake, body weight gain, feed efficiency and, and carcass traits, but higher dose of ZnO NP lowered malondialdehyde content and cooking loss in meat compared with 100 mg/kg of ZnO. Lina et al. [101] also observed increased GPx activity, total antioxidant activity in serum and reduced serum malondialdehyde content in Arbor Acres broiler chickens at 40 mg/kg of Zn supplementation from nano-ZnO. At higher levels (80 mg/kg) of Zn supplementation through either green nano-Zn or commercial nano-Zn in broiler birds showed significantly higher serum SOD, GPx, and catalase levels than their 40 and 60 mg/kg diet and inorganic Zn at 40, 60 or 80 mg/kg diet [74]. Ahmadi et al. [65] observed significantly increased SOD activity at 60–90 mg Zn/kg diet from ZnO NP in broiler chicken ration compared to 30 mg/kg diet. However, they observed inhibitory action of nano-Zn at further increased level (120 mg/kg diet) apparent from decreased SOD activity. Supplementation of 0.19 mg Se/kg diet from Se-NP increased serum SOD and GPx activity and decreased malondialdehyde concentration compared to 0.15 mg Se/kg diet from coarse Se in broiler birds [102]. Nano-Se at 0.3 mg/kg diet expressed improved GPx activity, free radical inhibition, immunoglobulin M concentration and decreased glutathione and malondialdehyde content in serum, improved GPx activity and free radical inhibition in liver and GPx activity in muscle [57]. Elkloub et al. [70] observed better total serum antioxidant activity in Ag-NP supplemented groups (2, 4, 6, 8, 10 mg/kg) and best in 4 mg/kg diet in Ag-NP supplemented group than un-supplemented group. Jankowski et al. [103] observed no adverse effect on antioxidant defense on reducing Mn concentration from 100 to 10 mg/kg diet in the form of NP-Mn2O3 whereas a 50% reduction in Mn level in the form of MnO enhanced lipid oxidation processes in turkeys.
Beneficial effect of different nanominerals in poultry production.
Trace essential minerals also act as immune stimulants in birds. Hence balanced mineral mixture is given much priority to maximize the animal or bird productivity and minimize the stress (biotic as well as abiotic) in animals and birds. Minerals particularly Zn, Cu, Se and Mn are studied on their immune-stimulant effects profusely, which may require at higher concentrations for better immunity compared with the optimum production levels [1, 2].
Different nanominerals have showed to exhibit better immune responses (Figure 3). Hafez et al. [100] observed enhanced cellular immunity evidenced from increases in serum IgY concentration, total lymphocyte count, macrophages, phagocytic activity and phagocytic index in ZnO-NP fed groups compared to ZnO supplemented group. Nano-Zn supplementation at 0.06 mg/kg in the basal diet improved immune status of broiler equivalent to that of 15 mg/kg diet of organic Zn supplementation in term of increased weight of lymphoid organs and improved humoral immunity [47]. Supplementation of ZnO-NP in dry broiler ration improved carcasses yield and relative weight of lymphoid and digestive organs compared to wet diet during the starter period [104, 105]. Retention of Se in liver and muscle increased in a dose dependent manner with dietary intake of nano-Se (0.3, 05, 1 and 2 mg/kg diet), but did not affect growth performance whereas improved meat quality, immune function, and oxidation resistance were observed for nano-Se level ranging from 0.3 to 1 mg/kg diet [57]. Addition of Cu-NP in drinking water (10 mg/l) improved immunity, and productivity more efficiently compared to coarse CuSO4 [106]. A study involving Cu-NP, agglomerates of Cu-NP and Cu microparticles on the metabolism in broiler chickens after a single intramuscular injection revealed that all these forms had growth stimulating effect along with increased red cell level, hemoglobin, Cu and protein in blood serum, where effects were expressed quickly by Cu-NP [107].
Pathogenic microbial load in the gut of poultry is detrimental as they reduce growth rate, feed efficiency and mortality, and are some of these contaminants may survive during food processing and storage. The in-feed antibiotics used for preventing the pathogens as well as growth promoters has been great concern due to possible emergence of drug resistance in microbes as well as appearance of the drug residue in poultry products and subsequently affecting consumer’s health [108]. There is an optimism of using nano-minerals as antibiotic alternatives due to their antimicrobial properties [109]. NP use has been established in therapeutics, drug delivery and diagnostics [110].
Many research carried has explored the antimicrobial action of metal oxide-NP [109]. Nano-Ag supplementation at 4 mg/kg diet in broiler chickens reduced serum cholesterol, aspartate aminotransferase levels and reduced caecal
In high intensified production system, trace minerals are added to poultry diets in high amounts exceeding the birds’ requirements, with a large safety margin, creating environmental issues particularly in areas of intensive poultry production [8]. A study reported that by using poultry manure, Zn content in soil was found in excess by 660% in comparison to plant Zn requirements, predisposing to phytotoxicity [119]. Among minerals, Fe, Cu and Mn are always found in excess than the amount required by the plants [8].
Poor retention efficiency on inorganic mineral sources leads to excretion of unabsorbed minerals to the environment, which may be a potential environment pollutant especially in the area of intensive poultry farming. Phosphorus excretion in poultry excreta from large scale poultry farming has been a matter of concern from environment pollution point of view. Predominantly, inorganic P sources are used in poultry ration for optimum growth, egg production which results in excretion of huge amount of P to the environment [1]. Improved absorption of minerals through NP may reduce excretion of unutilized minerals and could minimize the environmental pollution. Cufadar et al. [88] reported that the Zn content of the feces was less in poultry when they are supplemented with nano-Zn as compared to organic and inorganic Zn. Furthermore, Hassan et al. [69] found that DCP NP supplementation reduced excretion of Ca and P by 50.7 and 46.2%, respectively. Dietary Cu is absorbed in a range between 10 to 30% in the small intestine of the animal creating environmental issues [3, 92], but supplementation of nano-Cu has been proved effective in prevention of environmental leaching of unabsorbed Cu by virtue of its efficient intestinal absorption and also functions at the molecular level [120, 121]. Considering Zn, predominantly ZnO or ZnSO4 are used in commercial poultry feeds and among these, ZnO is used in 80–90% cases having less bioavailability [122]. Reports suggests nano-Zn are better absorbed in different animals [40, 41] and birds [47, 48], thus reducing the amount of Zn excreted to the environment, and environment pollution. Reports suggest that nano-Cr has better bioavailability than organic and inorganic Cr supplements [123]. Therefore, nanominerals offer opportunities to reducing environmental pollution of minerals without compromising the production, health and quality of products.
Trace minerals such as Se is essential in minute quantities in poultry diet to reduce stress, improve immunity and overall health, but safe limit of inorganic Se is very narrow. Hu et al. [51] observed a wider range between the optimal and toxic dietary levels of nano-Se compared to inorganic sodium selenite in broiler chickens. But contradictory reports exist regarding occurrence of severe pathological changes in liver due to increase in nano-Se concentration from 0.15 to 0.3 mg/kg diet [124]. One of the possible mechanisms of nano-Se action in poultry could be conversion of nano-Se into selenite, H2Se or Se-phosphate followed by synthesis of selenoproteins by gut microbiota, which was also reported by Surai et al. [125] in
Many other nanomaterials have been used in poultry nutrition. For instance, turmeric extract enclosed in a nanocapsule improved meat quality traits without affecting performance as a feed additive for regular broiler feed and 0.2% turmeric nanocapsule was the optimum level to obtain the best feed efficiency, whereas 0.4% of the nanocapsule decreased liver cholesterol and subcutaneous fat, but concentration at >0.4% reduced growth in birds [134]. Clay minerals of nano-suspensions added at 1 to 2% of the suspension in drinking water in broiler chickens were found to improve feed conversion ratio, body weight gain and antibody titer against Newcastle disease, infectious bronchitis and bursal disease [135]. There is huge potential of functionalizing many nanoparticles for application in poultry nutrition and feeding [32].
Minerals are obligatory for maintaining the higher productivity of poultry and a better bioavailable source at lower cost is the prime priority. In this context, nanominerals have produced encouraging responses in most of the studies. Though inconsistent, nano form of Zn, Se, Cu, Ca, and P mostly produced improved responses in poultry reflected by their performances such as body weight gain, feed efficiency, immune responses, egg production, egg quality traits, bone quality parameters, retention of minerals, and enzyme level. The inconsistent performance may be attributed to the level of minerals present in feeds itself and also the varied doses used depending on the hypothesis of the researchers. Many cases have given similar responses even by reducing the dose to half of the conventional inorganic doses, which is suggestive of better bioavailability. Apart from the biological effects in birds, the nanominerals are found to reduce the environmental excretion of the minerals by virtue of its better bioavailability and also reducing the dose of supplementation as well. Considering all the aspects, this can be suggested that use of nanominerals in poultry ration can be considered as an environmental protective strategy to augment poultry productivity. However, further studies with more replicates should be advocated along with long term exposure to validate and unveil more aspects of nanominerals.
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Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5365,totalCrossrefCites:23,totalDimensionsCites:55,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"71103",title:"Preparation of Nanoparticles",slug:"preparation-of-nanoparticles",totalDownloads:3140,totalCrossrefCites:11,totalDimensionsCites:25,abstract:"Innovative developments of science and engineering have progressed very fast toward the synthesis of nanomaterials to achieve unique properties that are not the same as the properties of the bulk materials. The particle reveals interesting properties at the dimension below 100 nm, mostly from two physical effects. The two physical effects are the quantization of electronic states apparent leading to very sensitive size-dependent effects such as optical and magnetic properties and the high surface-to-volume ratio modifies the thermal, mechanical, and chemical properties of materials. The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:71,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:75,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:124,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. By addressing hot topics in veterinary sciences, we aim to gather authoritative texts within each issue of this series, providing in-depth overviews and analysis for graduates, academics, and practitioners and foreseeing a deeper understanding of the subject. Forthcoming texts, written and edited by experienced researchers from both industry and academia, will also discuss scientific challenges faced today in Veterinary Medicine and Science. In brief, we hope that books in this series will provide accessible references for those interested or working in this field and encourage learning in a range of different topics.",coverUrl:"https://cdn.intechopen.com/series/covers/13.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:10,editor:{id:"38652",title:"Dr.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). 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Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. 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