TEP values for selected NHCs.
Abstract
The journey of “carbenes” is more than a century old. It began with a curiosity to understand a then less familiar carbon moiety in its divalent state. It reached an important milestone in the form of 1,3-imidazolium-based N-heterocyclic carbenes (NHCs), where the quest for bottleable carbenes was achieved through simple and elegant synthetic routes. The properties of these carbenes were finely tunable through the steric and electronic factors via chemical modifications. Thus, it became one of the unique and extensively studied ligands for its properties and applications. This chapter first briefs about structural details of NHCs and different synthetic routes for the preparation of imidazolium-based NHC precursors. The later section focuses on various methods for characterizing the steric and electronic properties of these ligands and their metal intermediates, which are crucial for developing efficient catalytic processes. Finally, the chapter concludes with NHC-metal-mediated catalytic applications and its immediate challenges.
Keywords
- N-heterocyclic carbenes
- imidazolium salts
- NHC-metal-mediated catalysis
- steric and electronic properties
- characterization of carbenes
1. Introduction
Carbon in its low coordinate divalent state is known as “carbene.” It is a well-known transient species in many catalytic reactions. Initially, the carbenes were considered to be very reactive and difficult to isolate. However, the carbenes were first stabilized as metal carbene complexes, which have found numerous applications in many important organometallic reactions. The challenge of isolating a stable metal-free carbene was ended in 1991, through the pioneering works of Arduengo et al. It was for the first time a stable metal-free N-heterocyclic carbene (NHC) was synthesized and isolated in the form of 1,3-di(adamantyl)imidazol-2-ylidene (IAd) by deprotonation of its 1,3-imidazolium salt precursor [1]. Thus, it enabled the easy synthesis of NHCs using simple synthetic routes and thereby extended its scope in synthetic organic chemistry. One such celebrated success is the role of NHCs as ligands in olefin metathesis [2].
1,3-Imidazolium salts are simple and stable precursors of NHCs. They are a good source for
In addition to the unique electronic features, the structural diversity of the NHCs was another important aspect that attracted the attention of chemists. The scope for variation of the ring size from 4 to 7-membered ring structures and the possibilities for substituent variations either at the N-atom or on the C-atom of the ring have tremendously increased the structural diversity of NHCs. Dimer, trimer, and poly NHCs are also known in the literature. Thus, the relatively easy access to structurally diverse NHCs and its flexible metal coordination has resulted in a large number of NHC-metal complexes. Based on the metal coordination to the NHC unit, they have been classified as normal, abnormal, and remote NHCs (Figure 2). If it binds to the metal through the C2 atom, then it is known as normal NHC; similarly if it is through the C4 atom, it is known as abnormal NHC. If there is an absence of a heteroatom in the α-position of the carbenic coordination center, it is known as remote NHC. Compared with normal NHCs, the abnormal NHCs have stronger donor ability and hence have direct impact on its catalytic efficacy [12].
The typical synthesis of NHCs were often accomplished by deprotonation of azolium salts, such as imidazolium, thiazolium, and triazolium. The focus of this chapter is primarily on the imidazolium-based NHCs. In the synthesis of imidazolium-based NHCs, there are three key components, which form the NHC framework. They are (1) carbon backbone, (2) pre-carbenic unit, and (3) amino unit [13]. Different synthetic strategies were evolved based on the construction of these three key components (Figure 3). Apart from the conventional synthetic methods, other methods such as electrochemical, microwave, and solvent free synthetic methods were also known [15, 16, 17]. Recently, the incorporation of one or more NHC units into a single carbon backbone was also reported, and these multidentate ligands were used to make poly NHC-metal complexes. These poly NHCs are capable of exhibiting different steric and electronic properties than the normal NHCs. Moreover, due to the inherent structural chirality, they are often studied for applications in asymmetric catalysis [18, 19, 20, 21, 22, 23].
Considering the scope and potential applications of imidazolium-based NHCs
2. Methods for assessing electronic and steric parameters of NHCs
2.1 IR spectroscopy: Tolman electronic parameters (TEP)
The most extensively used method for the determination of electronic properties of NHCs is based on the Tolman electronic parameters devised by Tolman in 1977, specifically for phosphines [24]. This technique uses tetrahedral Ni(CO)3L as model complex [25], where L is the ligand whose donor-acceptor abilities are under investigation. Carbonyl being a good π-acceptor has strong metal-to-carbonyl (dπ-pπ) back bonding. The introduction of ligands (L) with strong electron-donor properties will enhance the electron density around the metal (Ni) center in the Ni(CO)3L complex. Thus, by comparing the stretching frequencies of the carbonyl (CO) unit, various ligands (L) of interest were analyzed by their σ-donor properties. Ligands (L) with good σ-donor ability increase the metal-to-carbonyl back bonding. It results in stronger metal-ligand (Ni-L) bonding. Thus, it indirectly reduces the bond order of the carbonyl unit, and it will be reflected in the carbonyl IR stretching frequency (Figure 4). Nolan et al. were the first to systematically determine the TEP of NHCs using [Ni(CO)3(NHC)] as model complex. The critical limitation of this method is the preparation of a variety of nickel complexes using different NHC ligands. This synthesis requires the handling of NHCs with low boiling and toxic Ni(CO)4. Moreover, the TEP values are within a small window of 10 cm−1 and hence require high-resolution IR spectrophotometers. Any anomalies inherent to the IR measurement technique make this method more challenging. TEP depends on the steric factors since the steric can influence the complexes geometry, thereby the overlapping orbitals affect the TEP value. To overcome few of these shortcomings with respect to synthesis of analytical probes, Crabtree et al. [26] in 2003 reported the use of [(NHC)M(CO)2Cl], (M = Ir or Rh) complexes as the probe for determining the TEP. In 2008, Nolan et al. reported an extensive study on the Ir complexes for TEP determination of NHCs [27]. Compared with the earlier model complexes, an average of two carbonyl stretching vibration are taken into account due to
Sl. No. | NHC | TEP (cm−1) |
---|---|---|
1. | IAd | 2049.5 |
2. | IPr | 2051.5 |
3. | SIPr | 2052.2 |
4. | IMes | 2050.7 |
5. | ItBu | 2050.1 |
6. | ICy | 2049.6 |
2.2 NMR spectroscopy: σ-donor and π-acceptor abilities of NHCs
NMR spectroscopy, especially 13C and 1H NMR, are the most efficient and reliable techniques to understand the properties of NHCs, the NHC precursors, and related NHC-metal complexes. In general, imidazolium proton (-N-C(H)-N-) in NHCs is acidic due to its connection to the two adjacent electron-withdrawing nitrogen atoms. Hence, this proton appears in the deshielded region of proton NMR, around 8–12 ppm. However, upon deprotonation, the imidazolium proton signal disappears in the proton NMR. The 13C{1H} NMR spectra of NHCs exhibit the carbene (-N-C-N-) carbon peak close to the highly deshielded region of around 200–250 ppm for free carbene, whereas it is approximately 130–160 ppm for its respective precursor imidazolium salt. Due to the increased shielding effect, the highly shielded carbene carbon upon metal complexation, will undergo an upfield shift. Apart from a diagnostic tool, the NMR technique is helpful to explore various properties of NHCs such as (a) the steric properties; (b) σ-donor ability from ligand to the metal center; and (c) π-back bonding from metal to carbene. Understanding these parameters of NHCs is crucial for controlling the catalyst selectivity, reactivity, and efficiency. Earlier, the Tolman electronic parameters (TEP) obtained from the CO stretching frequencies of metal complexes such as [Ni(CO)3L] and [MCl(CO)2L] (M = Rh or Ir) were used to assess the electronic properties. However, this method has limitations due to inherent inaccuracies in IR spectroscopy measurements of metal complexes. Also, the necessity of preparing these complexes under highly inert conditions, the requirement of expensive metals, and the usage of highly toxic CO gas are the important drawbacks of the TEP method. Moreover, the TEP only gives information about the overall electron density around the metal center but not independent σ-donor or π-back bonding abilities.
Huynh et al. reported the unique use of NMR for studying the donor properties of NHCs [28]. This method utilizes the 13C-NMR technique, where the
Betrand et al. in 2013 reported the determination of π-acceptor ability of NHC ligands using the 31P chemical shift value of carbene-phosphine adducts, which exist in two different resonance forms “I” and “II” (Figure 6) [29]. The phosphaalkene form (I) has a P=C bond, and the form (II) has P-C dative bond with P having two lone pairs of electrons. The upfield phosphorus NMR chemical shift associated with P atom in the carbene-phosphine adducts agrees with the electron-rich resonance form (II). It suggests that the carbene carbon prefers a dative bond with phosphorus rather than a π bond. If the carbenes have π-accepting property, it should have reflected through a downfield shift in the 31P NMR.
Therefore, the NMR-based method provides an independent way to determine the π-accepting ability of NHC ligand, independent of its σ-donor abilities, which was one of the limitations of Tolman’s method for determining the electronic properties of NHCs. The arrangement of a few known NHCs according to their π-accepting ability, based on the 31P NMR chemical shift values, are provided in Figure 6.
Ganter et al. reported a similar technique in which the 77Se chemical shift of carbene-selenium adducts were used to assess the π-acceptor properties of the NHC ligands [30]. The carbene-selenium adduct exists in two different resonance forms (III) and (IV) (Figure 7), similar to that of carbene-phosphine adduct. The increase in the π-accepting property of the NHC is reflected through an increase in the chemical shift value of 77Se NMR. The arrangement of common NHCs according to their π-accepting ability was established based on the 77Se NMR chemical shifts (Figure 7). In addition to the π-acceptor ability, the σ-donor abilities of NHCs can also be found using carbon-selenium coupling constant values [31].
Szostak et al. [32] in 2019 reported a simple and straightforward method for the determination of the σ-donor properties of NHCs based on the Ccarbene-H coupling constant (
Thus, a large carbene carbon and proton coupling constant (
2.3 NMR and UV-Vis spectroscopy: p Ka of NHC precursors
Basicity and catalytic reactivity of NHC precursors (azolium salts) are intertwined. Therefore, the
Alder et al. reported the
Streitwieser et al. reported that the anomalies in the determination of
2.4 Electrochemical technique: redox potentials and basicity of NHCs
The architecture of NHC allows facile structural modifications, and hence, it provides an opportunity to fine-tune the properties. The reactivity of NHCs is controllable through the structural variations on its cyclic carbon backbone or the introduction of different heteroatoms such as S or O in the heterocyclic ring. The nature of counter anions in the precursor (i.e., imidazolium salts) will also affect the reactivity. Several external factors also contribute to the overall property of NHCs, such as the solvent effects, type of reagents in the reaction mixture, and temperature, etc. Therefore, considering all these factors, the electrochemical techniques will also be helpful for the easy identification of ideal conditions for optimizing the reactivity and efficient catalysis of NHCs. During the electrochemical reduction of imidazolium salt, the imidazolium proton (i.e., C2-H group of the cationic part) NHCH+ is reduced to NHC. In this case, the reactivity mainly depends on the NHC generated from the conjugated acid, that is, NHCH+.
The electrochemical studies of NHCs were first reported by Enders and Simonet et al. using triaryl-triazol-ylidene [39]. The cyclic voltammetry (CV) of imidazolium salts exhibited a reversible reduction, which can be due to single-electron reduction of NHCH+ to NHC (i.e., imidazolium salt to NHC) (Figure 12). Recently, Boydston et al. have also reported a systematic study on the redox behavior of a series of azolium salts, including benzothiazolium, thiazolinium, thiazolium, triazolium, imidazolium, and imidazolinium salts [40]. The study demonstrated that N-aryl moiety would be helpful to tune the reduction potential of the imidazolium ring [41]. The carbene generation usually depends upon the acidity of the NHCH+; hence, with an increase in the reduction potential, the acidity of the NHCH+ also increases [42]. Therefore, based on the electrochemical method, it is possible to choose appropriate NHC precursors [43]. A number of electrochemical studies related to the NHC metal complexes were also reported [44, 45, 46, 47, 48], the data of few selective NHC precursors (i.e., azolium salts) and its corresponding reduction potential are summarized from the literature (Table 2).
The overall electrochemical reduction potential will reflect the acidic nature of the cationic part of the NHC and its nucleophilicity (availability of lone pair). Therefore, the reduction potential data of the azolium salts will be helpful to gain insight into the nucleophilicity of different NHCs and identify the structural moieties that were crucial for a specific function or property. The catalytic efficiency of the NHC ligand primarily depends upon the nucleophilicity of carbene.
3. Steric properties of NHCs
Apart from the electronic properties, it is significant to understand the steric parameters of NHCs, since it plays a crucial role in the reductive elimination step of a catalytic cycle. In case of chiral NHCs, the steric parameters control the enantioselectivity of a catalytic reaction (Figure 13).
The earlier attempts to define the steric properties of NHCs were based on the Tolman cone angle [49], which is the solid angle made by an imaginary cone with metal atom at its apex, and ligands are at the outer edges (Figure 14a). The cone angle can be computationally calculated [51] or obtained from the single-crystal XRD data [52]. In the case of tertiary phosphine ligands, the cone angle was a well-defined concept; however, not in the case of NHCs, where it lacks a predominant three-dimensional symmetry. Thus, the determination of steric parameters, through the Tolman cone angle technique, was inappropriate for NHCs [49]. In order to overcome this, the concept of percentage of buried volume (%Vbur) was introduced by Nolan et al. [53], which is the percentage of total volume occupied by the ligand in an imaginary sphere of a well-defined radius and the metal atom residing at the center of the imaginary sphere (Figure 14b). This parameter can be determined either from the single-crystal XRD data or can be calculated computationally (Figure 14c). The nature of backbone, N-substituents, and the ring size are the various factors that influence the percentage of buried volume (% Vbur).
Several advancements in the steric parameter determination of NHCs came up with the introduction of Salerno molecular buried volume calculation (Samb
4. Catalytic applications of NHC-metal complexes
In 1962, Wanzlick et al. made the early reports on the stability and reactivity of NHCs [55]. Later in 1968, the first NHC-mercury complex was isolated [56]. Despite this isolation, the studies related to the NHCs as ligands thrived only after the first isolation report by Arduengo et al. in 1991 [1]. This easy synthetic strategy facilitated the extensive studies of NHC-metal complexes and their catalytic applications. The catalytic applications of NHCs as ligands can be broadly classified into three types, and they are (a) NHCs for organocatalysis [57, 58, 59], (b) NHCs as ligands for transition metal catalysis, and (c) NHCs and main group elements-based adducts for catalysis [60]. The following section of this chapter focuses on few selective and important NHC-transition metal catalyzed reactions (Figure 15), since the complete details are beyond the scope of this chapter.
4.1 NHC-transition metal catalyzed cross-coupling reactions
The coupling reactions catalyzed by transition metal-NHC complexes involve both C-C bond formation reactions such as Mizoroki-Heck [61, 62], Sonogashira [63, 64, 65], Negishi [66, 67, 68], Hiyama [69, 70, 71], Suzuki-Miyaura [72, 73, 74], Kumada coupling [75, 76], C-X (X = B, N, O) bond formation reactions such as Buchwald-Hartwig amination [77, 78, 79] and Ullmann coupling [80, 81, 82] etc. Recently, the coupling reactions catalyzed by the NHC-transition metal complexes have found to be efficient with commercially viable metal salts such as iron, cobalt, and nickel. For example, the cross-coupling of methyl sulfonates and amines to afford sulfonamides uses Ni/NHC system to form the S-N bond [83]. Few well-known NHC-metal catalyzed reactions are shown in (Figure 16).
Recently, the Pd-NHC catalyzed metathesis of carbon-sulfur bonds seems to be one of the significant reactions, which is capable of altering the trends in the retrosynthetic approach for the preparation of organosulfur compounds [60] (Figure 17).
4.2 NHC-transition-metal-mediated metathesis reactions
One of the best examples to demonstrate the significance of organometallic complexes is their role as catalysts in olefin metathesis, which is having numerous synthetic applications and commercial significance. There are different types of olefin metathesis, namely ring-opening metathesis polymerization (ROMP), ring-closure metathesis (RCM), olefin cross metathesis, and enyne cross-metathesis. The ruthenium complex with a nonlabile NHC group and a labile phosphine group known to exhibit higher ring-closure metathesis (RCM) activity with better thermal stability and has tolerance toward many functional groups [14]. In general, the metathesis catalyst prefers the formation of thermodynamically favored E-isomer. However, subsequent modification on the NHC group yielded Z-isomer in significant yields. Chelating NHC-Ru complexes gave upto 95% Z selectivity. The unique steric and electronic parameters of chelating-Ru-based NHCs promote the olefin to attack cis to NHC and trans to the chelating group. This side-bound reaction mechanism results in Z-isomer as predominant product. One example of such Z-selective olefin metathesis using NHC chelated Ru-catalyst is shown (Figure 18) [84].
4.3 NHC-transition-metal-mediated addition reactions
Hydrogenation [85], transfer hydrogenation [86], hydrosilylation [87], hydroboration, and hydroamination [88] are the different types of NHC-transition metal catalyzed addition reactions. A brief outline of the various addition reactions catalyzed by NHC-transition metal complexes is summarized in Figure 19.
4.4 NHC-transition-metal-mediated catalysis—Flow chemistry
Continuous flow chemistry is a revolutionary technology that has developed rapidly during the past few years. The small size of channel reactors enables increased mass transfer, efficient heat transfer, and enhanced reaction efficiency. Moreover, this method enables the handling of dangerously toxic reagents remotely and thus reduces the potential health risks [89, 90, 91, 92]. Cole-Hamilton et al. [93] reported the first continuous flow-based olefin metathesis catalytic system with a homogeneous catalyst. In this method, the Ru-NHC catalyst was immobilized into silica pores, and CO2 was passed as the carrier gas (Figure 20). It gave the metathesis products with an overall turnover number > 10,000.
Jenson et al. [94] reported a continuous nanofiltration method in which the metathesis catalyst (Ru-NHC) was allowed to react homogeneously; upon the reaction completion, the catalyst is trapped into a nano-filter setup, and it is flushed back to continue the reaction cycle. Unlike other conventional methods, there are no modifications done to the catalyst to recover and reuse it. Fabrication of NHC-metal complexes onto solid supports such as silica is another strategy used in NHC-centered flow chemistry [95, 96, 97, 98]. Functionalized catalyst is packed into a reactor, and the reagents are forced to pass through it to yield final products (Figure 21).
5. Conclusions
The imidazolium-based N-heterocyclic carbenes (NHCs) have found to be excellent candidates for improvising their properties through chemical modifications. Basic understanding and assessment of the steric and electronic factors of NHCs are crucial to explore its catalytic applications. Therefore, this chapter attempts to provide a basic glimpse of imidazolium-based NHCs through the discussions on some important synthetic routes, different methods for characterizing the electronic and steric properties of NHCs, and finally, few selective catalytic applications. Even though the literature pertaining to the imidazolium-based NHCs and its applications is vast and rapidly increasing, the discussions were limited to few important topics. Despite the extensive studies on imidazolium-based N-heterocyclic carbenes, there is plenty of scope for improvement, particularly enhancing the catalytic efficiency of NHCs with inexpensive metals, reducing the catalyst load, exploring new catalytic reactions with variety of substrates, and most significantly, making the NHC-based catalysts ready for more green and sustainable reactions.
Acknowledgments
VBG gratefully acknowledges Science and Engineering Research Board (SERB), New Delhi, for research funding (EEQ/2016/000837) and fellowship to BPJ. Thanks to the funding, it gave us an opportunity to initiate and establish our work in this exciting field on imidazolium-based NHC chemistry. Authors are also thankful to the Department of Chemistry, School of Basic and Applied Sciences, Central University of Tamil Nadu, Thiruvarur, India.
Appendices and nomenclature
NHC | N-heterocyclic carbene |
HOMO | highest occupied molecular orbital |
LUMO | lowest unoccupied molecular orbital |
TEP | Tolman electronic parameters |
IAd | 1,3-di(adamantyl)imidazol-2-ylidene |
IMes | 1,3-di(mesityl)imidazol-2-ylidene |
IPr | 1,3-di(2,6-diisopropyl)imidazol-2-ylidene |
NMR | nuclear magnetic resonance |
CV | cyclic voltammetry |
SambVca | Salerno molecular buried volume calculation |
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