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1. Introduction
Robotics courses, after-school programs, and teams are highly sought-after by school districts and parents who wish to provide their students with science, technology, engineering, and math (STEM) instruction to cultivate a foothold for children in future STEM majors and careers [1, 2, 3]. Acquiring physical robotic kits, tools, building and testing space, storage units, computer equipment, and software can be an expensive and time-consuming proposition. Funding for this scope of sustained classroom robotics ranges from well-organized parent-teacher committees [4], business sponsors in return for advertisements on t-shirts [5], and grants from non-profit robot competition entities such as Vex Robotics Education Competition Foundation [6].
The ratio of student-to-robot varies as children enroll in a class, program, or team. A small classroom bundle of robots, such as the Vex IQ, provides five kits, a 12-tile playfield, 18 generic game objects, storage bins, five “pin tools,” and costs approximately $2250 [7]. In a classroom, club, or team of 20 students, this kit provides a 4:1 ratio of students to a robot. Classrooms and clubs can implement a generic “build” such as the Vex IQ Clawbot robot to practice fundamental robotics. Competitions, which change every year, require a custom build to enact the unique game established as a challenge by non-profit organizations such as Vex or FIRST Robotics. A team wishing to practice-to-win with their uniquely engineered robot could invest in a competition-size playfield and purchase the new game pieces each year.
With the physical requirements of robotics established, this still leaves teachers and parents with the imperative to provide all students with the opportunity to plan, engineer, build, program, and test a robot. Every physical robotic platform is a synthesis of hardware, software, and firmware. The definition of each of these terms is as follows:
Hardware is the collection of the physical components of the robot. The robot’s brain, sometimes called a brick, contains ports that connect to motors and sensors using cables of varying lengths and memory boards to house software instructions downloaded from the students’ shared computer.
Software is a general term that describes computer programs. The programs include the operating system that resides in the robot’s brain to communicate with the programs we write in C, C++, or Python to instruct the robot to move and sense its surroundings.
Firmware is the collection of instructions in the brain, motors, and sensors that allow the hardware to communicate and enact our programs.
Teachers, parents, and coaches are frequently at a loss of where to begin. This chapter delineates the implementation of virtual robotics as an on-ramp to familiarize educators and their stakeholders with the fundamentals of programming a robot to navigate a virtual world through a simulated physics algorithm. Virtual reality (VR) is a technology that immerses the user into a coded environment that employs visual output to depict different surroundings other than the real world. VR is typically associated with a headset such as Google Cardboard [8] or Merge VR headsets [9] that the user wears to block out the real world and experience new visual input. Vex VR and Robot Virtual Worlds are examples of virtual worlds that depict robots in a computer-generated environment without the use of goggles or headsets. The user observes the robot in an environment on their computer screen.
Virtual robotics provides educators, parents, and coaches with a 1:1 learner to robot ratio. Adults supporting robots in the classrooms, clubs, and competitions should understand the world of robots before making a substantial financial and time investment in physical kits, dedicated building & testing space, and the logistics to field a competition-ready team.
The following sections employ the technological pedagogical and content knowledge (TPACK) framework [10] that delineates the necessary knowledgebase to understand the intersections of teaching methods and content knowledge (Figure 1) to instruct with technology effectively. Robotics brings science and math instruction to the forefront as students must understand scientific content such as force and friction and mathematical concepts such as circle geometry. Pedagogy embodies the methods and teaching practices of the component disciplines of science, technology, and math. The ultimate intersection of technology, pedagogy, and content knowledge (TPACK) provides a solid on-ramp to robotics.
Figure 1.
Diagram of the intersections of the TPACK framework.
Using TPACK as a framework, the remaining sections of this chapter discuss the following virtual robotics platforms and supporting applications:
Vex VR [11], a no-cost, browser-based virtual robotic platform.
Robot Virtual Worlds [12], a licensed software package that includes a customizable virtual world called Level Builder.
Tinkercad [13] – a computer-aided design (CAD) 3D modeling program offered by Autocad where students create objects to upload “.stl” files to Robot Virtual Worlds’ [12] Level Builder.
Merge Cube [14] – an augmented reality mobile application program that facilitates viewing student-designed 3D objects to “see” their creation before uploading to Level Builder or printing on a 3D printer.
This chapter concludes with a summary of virtual robotics and suggested transitions using a hybrid approach to virtual and physical robotics.
2. Vex VR
Vex VR is a browser-based virtual robot platform provided by the Vex Robotics Education & Competition (REC) Foundation. This platform is an ideal place to introduce students, teachers, parents, and coaches to the world of robotics. Educators can consider the VR Vex platform as a tool to use with students in face-to-face and synchronous or asynchronous online environments. The goal is to provide all students with the same learning opportunities. It is essential to consider how educators can use platforms such as Google Classroom [15] and Google Drive [16] to deliver supporting content, such as worksheets, to students. Online materials become accessible to all hybrid learners in the same room, joining via Google Meet [17], or who must enact the lessons when they have access to a shared home computer. Creating multiple entry points for students in a hybrid approach is the ultimate in student-centered learning.
With the hybrid “classroom” organization established, let us define programming. By this author’s definition, programming is writing instructions to cause an object made of plastic, glass, rare metals, and electricity to solve logical and mathematical statements repetitively.
There are several ground rules for every programmer to consider as they journey into this fantastic field of coding and robotics. First and foremost, the program is doing what it is doing because that is what you told it to do. Programmers must think of how the computer interprets our instructions, not how we believe the code should work. Next, concise code is best. Programming is not a competition to write the most lines of code. Concise lines of instructions take up less of the computer’s memory and will run faster. Persistent programmers write great programs. Finish a job. Be proud of your product. Finally, share what you know. Robotics communities have robust collaborative forums and videos on social media. Share techniques to help up-and-coming teams.
2.1 Vex VR technological knowledge (TK)
This section addresses the technical knowledge in the TPACK framework (Figure 1) necessary to implement the fundamentals of Vex VR. Since Vex VR is browser-based, there is no need to download software to each student’s computer. A browser is software on your computer that communicates with a website’s server, an extensive array of disk drives, that responds to your interactions when connected to the internet. Browsers such as Google Chrome [18] create a local, temporary file on each computer called cache. However, this temporary file resides on an individual computer and does not necessarily store a student’s Vex VR “.vrblocks” file when the computer shuts down. The Vex VR software does allow students to export their developing program to the hard drive of their computer. At this juncture, educators should consider using Google Classroom [15] or the Google Drive [16] of their Gmail account to create folders for each student to upload their exported “.vrblocks” work-in-progress to their Google folder each time they finish a programming session. Using Google Drive to store files is particularly helpful if two students used the same device on different days or if a student is returning to school after working from home. Creating this workflow organization and reminding students to save, export, and upload their work to their Google folder saves time and frustration. Teach the students to rename each upload of their “.vrblocks” file with their name and date. For instance, Mistretta110921.vrblocks. Naming the file avoids confusion with prior iterations of the program and improves students’ organizational skills. Google Drive [16] is capable of housing the “.vrblocks” file. One must download the file to your computer and import it to Vex VR to continue to program.
2.2 Vex VR content knowledge: science and math (CK)
This section addresses the science and math content knowledge in the TPACK framework (Figure 1) that underpin the natural forces and numeracy at work. Robotics is the glue that holds STEM together. The science topic of ultrasonic soundwaves correlates to the distance sensors on robots. The Vex VR software simulates the use of ultrasonic sound waves through a physics algorithm to measure the distance from an object in the robot’s virtual environment. Educators can connect to the echolocation of bats and dolphins as an activity to explore the properties of ultrasound before teaching the blocks that detect the distance from an object to the robot’s sensor. It is important to make these connections to students’ schema, or prior knowledge, to other natural systems that use echolocation.
Kindly refer to Video 1, https://drive.google.com/file/d/1CuYGgckdw5xhYdXFu1jzvtdbHiyeJ8zg/view?usp=sharing and Figure 2 as you read the following descriptions of the Vex VR platform. The Vex VR Playground [11], selected in the upper right-hand corner of the blue ribbon on the screen, provides challenges to practice moving the robot around obstacles. This author recommends the Wall Maze (not the Dynamic Wall maze that changes with each run of the program) as a good beginner activity to discover the capabilities of the virtual robot. The programmer has the option to reveal a monitor by clicking the button located just above the camera icons in the lower right-hand corner of the Playground pop up window to display the values of the following virtual sensors: front eye, down eye, XY axis location, location angle, bumper value, and distance in millimeters from an object. Based on the readout of the sensors, the programmer can code the robot to stop when the distance threshold is less than a number that they observe on the monitor. Writing code based on the sensor monitor is a tangible application of math to employ comparison operators to calculate when the robot must stop and turn.
Figure 2.
VR vex platform. VR vex is a product of the Robotics Education & Competition (REC) foundation.
2.3 Vex VR technological content knowledge (TCK)
This section elaborates on the intersections of technical and content knowledge (Figure 1) necessary to understand Vex VR. Students who have prior knowledge of programming on the Scratch platform [19], or other websites that use block coding, will recognize the structure of the Vex VR integrated development environment (IDE). Like Scratch programming [19], the code blocks are drag and drop puzzle pieces that join together in the large white work area that dominates the right two-thirds of the screen (Figure 3). Vex VR organizes the blocks into 10 categories: Drivetrain, Magnet, Looks, Events, Control, Sensing, Operators, Variables, My Blocks, and Comments. Vex VR provides you with the “when started” block. The programmer subsequently connects additional blocks based on planning strategies.
Figure 3.
VR vex work area, block categories, and resources. VR vex is a product of the Robotics Education & Competition (REC) foundation.
To learn more about each block, the programmer can click on the question mark in the upper right-hand corner of the screen (Figure 2) and then click on a block in the column that contains the puzzle pieces on the left of the screen. The “Help” column will populate with information about the selected block. To learn more about topics such as “Driving Forward and Backward” or “Turning,” click on the “Tutorials” button under the lightbulb icon in the top blue “ribbon” of the screen. Vex VR provides a robust Level 1 Blocks Course collection to get the students started.
This section introduces the pedagogical, teaching methods, knowledge (Figure 1) necessary to instruct virtual robotics. Computational thinking is a mindset that is not limited to programming and computer science. It is a set of skills and attitudes that support students’ creative solutions. Educators new to STEM might consider problem-solving as the only component of computational thinking. However, there are two additional skills: abstraction and algorithmic thinking [20]. Educators must emphasize that a computational thinking methodology is an iterative approach where mistakes and adjustments are an expected component of the process. Table 1 summarizes the essential elements of the three computational thinking skills with examples based on the Vex VR Wall Maze challenge [11].
Skill
Sub-skill
Example
Problem solving
Decomposition
Student evaluates the Wall Maze to break down the entire maze (large problem) into smaller problems to navigate obstacles from start to finish.
Redefine Problems
Student examines available code blocks and robot sensors.
Strategic Decision Making
Student develops several possible solutions and decides which blocks and sensors to employ.
Abstraction
Modeling
Beginner programmer: Student programs a solution using multiple instances of the same blocks to navigate the maze. This can create a very long, concatenated grouping of code.
Pattern Recognition
Intermediate programmer: Student recognizes that the same blocks are used repetitively.
Modularity
Advanced programmer: Student identifies generalizable modules using the “My Blocks” feature that consolidates the movements of the robot into recognizing walls with the distance sensor, the bumper switch, left, and right turns.
Algorithmic Thinking
Algorithmic Design
Student develops a step-by-step strategy to call the “My Blocks” modules to create concise code (Figure 3).
Incremental Design and Evaluation
Student designs, test, and revises code in an iterative approach to solve the maze.
Table 1.
Summary of three computational thinking skills.
2.5 Vex VR pedagogical content knowledge (PCK)
This section addresses the intersection of pedagogy and content knowledge. Pedagogy is an art, especially when teaching technology. The methods of pedagogy seek multiple entry points to introduce content and provide all students with the opportunity to practice, make mistakes, revise, and reveal understanding. Giving guidance to each student is crucial to advance their knowledge of programming. Feedback, however, is only one of three components that comprise formative assessments. Hattie and Temperly [21] provide a tri-directional model of helpful feedback: feed up, feedback, and feed forward. Table 2 elaborates on the three directions of formative assessments.
Feed Up
“Where am I going?” – Does the student’s developing project exhibit an understanding of the goal of the assignment? Check the student’s understanding before they potentially progress too far in the wrong direction.
Feedback
“How am I going? – As students and educators, we are familiar with the prevailing direction of feedback that answers the questions, “What progress has the student made toward the goal?” With feedback, educators give students input to the overarching question, “How am I going?” that informs students about the trajectory of their work toward the goal. Students frequently ask, “Am I on the right track?”
Feed Forward
“Where to next?” – Offer substantive suggestions to inform students about specific activities that they need to undertake to make progress toward the goal.
This section discusses the intersections of pedagogy and technology to offer supporting applications to provide feed up, feedback, and feed forward guidance. There are several applications that assist teachers to provide impactful information to students. The categories are audio, screen recording with voiceover, and image annotation (Table 3). These tools work in face-to-face and online synchronous or asynchronous classwork.
Screen recording with voiceover and optional on-camera speaker.
Install the Chrome Loom extension on your computer. Download code from your student’s Google folder and upload the “.vrblocks” file to the VR Vex in your browser. Review the program to formulate suggested revisions. Click on the Loom extension in your Chrome toolbar and screen record your feedback to your student. Click the Loom checkmark at the bottom of the screen to generate a URL to your feedback. Send the URL to the student via email.
Small-skill videos
It is helpful to produce small skill videos (Video 1, https://drive.google.com/file/d/1CuYGgckdw5xhYdXFu1jzvtdbHiyeJ8zg/view?usp=sharing), using Loom, to share with students to cover programming techniques. Students can revisit a collection of educator-produced videos to review a skill or work ahead. This is helpful to bring new students up to speed or advanced students to progress ahead. Educators can archive the videos on Google Classroom [15], Google Site [24], or Wakelet [25].
Skitch is part of the Evernote application. Download Skitch to your computer. Take a screenshot of your student’s work with the Skitch application. Use the annotation and text tools to point out the areas of the program or assignment to revise. Figures 2 and 3 are examples of Skitch annotations.
Table 3.
Feed up, feedback, and feed forward tools for educators.
The successful deployment of the Vex VR platform in a hybrid learning environment with face-to-face, synchronous, and asynchronous entry points compels teachers, coaches, and parents to understand the intersections of technology, pedagogy, and content knowledge. The on-ramp of the browser-based, virtual robotics, Vex VR platform transitions well to the next section that delineates Robomatter’s Robot Virtual Worlds platform [12].
3. Robot virtual worlds
The Robot Virtual Worlds (RVW) product, offered by Robomatter, Inc., provides a powerful virtual robot platform [27] that gives programmers an option to run their code on a virtual or physical robot. The following information describes the setup of a Windows-based computer lab or laptop cart in one building. RVW is licensed software that has an option to obtain a 30-seat perpetual, one-time purchase for Vex or Lego Mindstorm robots [12]. Robomatter wrote RVW to work with the Windows operating system. One must download and install the licenses on each computer running the Windows operating system or to each Apple or Chrome computer running a Windows “partition” such as Parallels [28] software on a Mac OS or Chrome OS device. A partition is a region of your computer’s memory dedicated to simulating the Windows operating system. The cost of a 30-seat, perpetual RVW license is approximately $600 with an available trial license to test-drive the software [12]. The Robot Virtual Worlds Level Builder, akin to the VR Vex playground, is free. Download a Level Builder package to each computer using Robot Virtual Worlds to “play” challenges or “build” a custom virtual world.
To facilitate students working from home, RVW offers homework pack licenses [12] to install on students’ home computers running the Windows operating system. If a student owns a Mac or Chrome computer, the cost to the student for the partition software is approximately $80. Each student should download the free Level Builder software to facilitate “play” challenges or “build” custom activities. The following sections describe the RVW Vex IQ virtual robot.
3.1 RVW technological knowledge (TK)
This section addresses the technical knowledge in the TPACK framework (Figure 1) necessary to implement the fundamentals of the RVW RobotC programming software focusing on a Vex IQ virtual robot. The “C” programming language is an industry standard to program robots [29]. RVW provides a graphical user interface (GUI) with drag and drop blocks similar to VR Vex. Once installed on a computer, RVW provides a desktop icon named ROBOTC for Vex Robotics. Double click on this icon to invoke ROBOTC. Kindly refer to Video 2, https://drive.google.com/file/d/1Aj0sxMaZGRnMeIIa0Ni-jmis9fp7rQjj/view?usp=sharing and Table 4 that contain suggested steps for educators to establish RVW on each licensed computer, to create a simple program, and to run this program in the Turning Challenge virtual world.
Task
Location in top gray row of the robotC Screen
Notes
Establish licenses
Help – Manage Licenses – Add License
One per computer.
RVW Package Manager to Install Level Builder
Help – Manage RVW Packages – Checkmark all Packages – Click Install/Update Selected
This is where you install Level Builder. One can also install the Vex IQ Competition Challenges [30] in virtual format here.
Review the Help Page
Help – (Choose language)
Review the extensive library of this user manual as needed.
Select the Virtual Robot
Robot – Compiler Target – Virtual Worlds
This will download your programs to the virtual robot. When one builds a Vex IQ, select Physical Robot and attach the Vex IQ with the USB cord.
Select the Platform Type
Robot – Platform Type – Vex IQ and Robot – Platform Type – Vex Robotics – Vex IQ
This example describes the Vex IQ virtual robot. The Vex Cortex virtual robot is also an option.
Select Virtual World to Use
Window – Select Virtual World to Use – RVW Level Builder
This menu option contains a “Download More Packages” option.
Select Menu Level
Window – Menu Level – Super User
The Super User options shows all available blocks.
Open a sample program
File – Open Sample Program
Select Moving Forward Rotations
Compile the Program
Click the Compile Program button at the top of the screen.
One must compile the program each time you make a change.
Download to the Virtual Robot
Click the Download to Robot button at the top of the screen
One must download the program each time you make a change. Click Play to reveal the Clawbot IQ page.
Select the Level
Select the Turning Challenge as a good beginner activity.
Click “Start Level” to reveal the virtual robot on the playfield. Notice the “play” button to the left of the robot. Click play to enact your program, click the rewind to return to the Start tile, click the “home” icon to return to the Select Level option.
Table 4.
Suggested sequence to establish RVW.
3.2 RVW content knowledge – sensors and geometry (CK)
This section addresses the engineering and geometry content knowledge in the TPACK framework (Figure 1) that underpin the robot’s build and associated properties of circle geometry at work. The RVW Vex IQ virtual robot has the same construction and sensors as the physical kit’s “Clawbot” build. A sensor is a device attached to the robot’s brain that detects the environment and sends numbers to the brain to report its findings. The programmer writes the code to respond to the robot’s data to navigate the environment. Table 5 lists the Vex IQ sensors, their purpose, and an example of how to use the sensor in a program.
Sensor
(P)urpose and (V)alues
Example
Bumper Switch
P: detect an obstacle V: pressed = 1 released = 0
&$$$; [29] This loop of code will move the robot forward one rotation at half power until the bumper switch is pressed indicating that it drove into an object.
Distance Sensor
P: Detects an obstacle with ultrasonic soundwaves V: Measures distance from 50 mm to 1 m
&$$$; [29] This loop of code will move the robot backward one rotation at half power until the distance sensor detects that an object is less than 300 millimeters away. Note: the virtual robot has its distance sensor on the back bumper. Hence, one must turn the robot to face the distance sensor toward the object that you wish to detect
Gyro Sensor
P: Measure the turn rate and calculates the direction of the robot. V: based on 360 degrees of a circle.
&$$$; [29] Always reset the gyro sensor (to 0) before turning the robot
A gyro turning counterclockwise will increase its values. A gyro turning clockwise will decrease its values.
This loop of code turns the robot to the left by setting the speed of the robot’s left motor to −50 and the right motor to 50 until the gyro value is greater than 90 degrees.
Touch LED
P: In virtual robotics, set the LED to color to denote that a section of code is being enacted V: For example, colorRed, colorGreen.
&$$$; [29] For example, set the touch LED sensor to a different color for each section of code for a visual indication that a section of code is currently running.
Color Sensor
P: Detects the color of obstacles. V: Returns a color name or value of red, green, and blue in 256 levels.
P: Using an encoder within the motor, it measures speed, direction, time, revolutions, and degrees of turn. V: See example.
&$$$; [29] This block moves the robot forward for three rotations of the wheel at half power.
Table 5.
Robot sensors with examples.
It is necessary to understand circle geometry to employ the 360° properties of a circle to calculate the turns of the robot using the gyro. Additionally, students can arrive at the circumference of the robot’s wheel to determine the distance in millimeters that the device travels in one rotation. Notice the length of the radius of the Clawbot IQ wheels on the start page of the Level Builder virtual robot (Video 2, https://drive.google.com/file/d/1Aj0sxMaZGRnMeIIa0Ni-jmis9fp7rQjj/view?usp=sharing). The radius of the wheel is 3.2 cm. Therefore, the diameter of this circle is 6.4 cm. Students can use the formula Π * 6.4 to calculate the circumference of the wheel to arrive at the distance that the robot wheel travels in one rotation. The circumference of the wheel in centimeters is approximately 20 cm or 200 mm. Using the measuring beam on the virtual robot, the student can calculate how many rotations it will take to travel the Turning Challenge depicted in Video 2, https://drive.google.com/file/d/1Aj0sxMaZGRnMeIIa0Ni-jmis9fp7rQjj/view?usp=sharing.
3.3 RVW technological content knowledge (TCK)
This section elaborates on the intersections of technical and content knowledge (Figure 1) necessary to understand Robot Virtual Worlds. Similar to the drag and drop code blocks described in Section 2.3, RVW is a robust platform that provides RobotC programming in 12 graphical functions categories (Table 6).
Graphical Function
Use
Program Flow
Contains blocks that the programmer to evaluate the data coming in from the sensors as the robot travels in an environment. The program flow blocks contain three components: the name of the sensor, a comparison symbol such as less than < or greater than >, and a threshold value such as a number, a color, or a Boolean value such as true or false.
&$$$; [29] This program flow block evaluates the gyro sensor data and will turn the robot to the right until the value is less than −89.
Variables
The variable blocks allow the programmer to create a named location in the memory of the brain to store a value to use in a programming block.
&$$$; [29] The programmer established the variable MyPower, set the value to 100, and then used the variable in the forward block. Using a variable in this manner standardizes the power. The programmer changes the value in one place and recompiles to change the speed of the robot throughout the program.
Simple Behaviors
Contains backward, forward, moveMotor, turnLeft, and turnRight commands. Use the Help – Command Library Vex IQ – Graphical – Simple Behaviors user manual to learn more.
Motor Commands
Contains blocks that address the encoder properties of the motor sensors. Use the Help – Command Library Vex IQ – Graphical – Motor Commands user manual to learn more.
Remote Control
Contains blocks to program the handheld controller that communicates via radio in physical robots.
Timing
Contains blocks to time or delay the program.
Line Tracking
Contains blocks to follow the edge of a line with the color sensor.
Datalog
Creates a graph of data from a selected sensor.
Display
Used to reveal controller, motor, or sensor values on the screen of the brain.
TouchLed
Changes the color on the TouchLED sensor
Distance and Gyro Sensor
Contains blocks to reset the distance and gyro sensors.
Table 6.
Robot virtual worlds 12 graphical function categories.
This section suggests a pedagogical method (Figure 1) to make real world connections to robotics as students program their virtual robot. The Mars Perseverance Rover is a robot launched by NASA in July of 2020 and deployed on Mars on February 18, 2021 [31]. The Perseverance mission team engineered the rover to utilize a sophisticated collection of cameras and sensors to navigate the environment of Mars [32]. However, one simple calculation correlates directly to the students’ virtual robot and circle geometry. The mission team calculated the distance that Perseverance travels in one rotation of the wheels, with no slippage on the rocky terrain of Mars, as 1.65 meters [33] using the same formula for the circumference of a circle demonstrated in Section 3.2 of this chapter. Educational philosopher John Dewey asserted that, “We do not learn from experience. We learn from reflecting on experience” [34]. Take the time to have the students pause and reflect on the rover on Mars to appreciate the skills that they are learning as actionable in future STEM careers.
3.5 RVW pedagogical content knowledge (PCK)
To achieve the intersections of pedagogy and content knowledge, teachers, coaches, and parents can reflect on the three types of problems delineated by Kirkley in the Principles for Teaching Problem Solving [35]. The students enacting virtual robotics will solve ill-structured problems without one solution. For every student in a class or on a team, they can develop a unique solution that solves the successful navigation of the virtual robot around the selected challenge. Table 7 reveals three types of problems and the implications for instructing virtual robotics.
Type
Definition
Example
Pedagogy
Well-structured problem
The same step by step solution with one right answer.
Calculating the circumference of the wheel of a robot using Π * Diameter
Learner memorizes formula.
Encourage reflection to real world contexts such as the Perseverance Rover.
Moderately structured problem
More than one acceptable solution with one right answer.
Turn the robot 90° to the right to navigate a maze. The learner can use the gyro sensor and setMotor blocks in a repeatUntil loop or a simple behavior of turnRight. Both solutions will turn the robot 90° to the right.
Learner selects a strategy to turn the robot to the right 90°. The solution using the gyro requires more analysis and abstract reasoning.
Encourage students using the simple behavior to develop a solution to employ the gyro and motors.
Ill-structured problem
This is an open-ended problem with many correct solutions.
Challenge the students to move around a maze using all available sensors in their solution.
Students must plan the direction of the rover to move forward to use the bumper switch, backward to use the distance sensor, motor encoders to calculate distance traveled to navigate the robot to the finish block.
This section discusses the intersections of pedagogy and technology to offer supporting applications for students to develop their strategies to solve ill-structured problems. Students who complete the challenges provided within the RVW Level Builder software, such as the Turning Challenge, will be ready to create their own virtual environment. As previously demonstrated (Video 2, https://drive.google.com/file/d/1Aj0sxMaZGRnMeIIa0Ni-jmis9fp7rQjj/view?usp=sharing) there are two options to enact a program in RVW Level Builder. The first is “Play” and the second is “Build.” When the programmer selects “Build”, the system presents a blank playfield with one “Start” Block (Figure 4).
Students can customize their virtual Level Builder environment by dragging and dropping objects provided by RVW onto the playfield and saving their unique environment for continued development (Figure 4). Most exciting is that the student can create 3D objects using free online platforms such as Tinkercad [13] offered by Autodesk [Autodesk], export the resulting “.stl” file to the download folder of their computer, and import this file to Level Builder (Video 3, https://drive.google.com/file/d/1ddxnW7pp3KdELAbh53vAfdSC5spGUEp0/view?usp=sharing). Their custom 3D object becomes an obstacle to navigate around or an object to be “picked up” and carried by the arm and claw of the Clawbot Vex IQ virtual robot.
3.6.2 View custom 3D objects in augmented reality
Thus far, this chapter discussed the Vex VR and Robot Virtual Worlds virtual reality applications where the user observes a robot navigating a coded environment on a computer screen. Augmented Reality (AR) is a technology that overlays digital information into a user’s real surroundings. Learners use a mobile phone or tablet running an application such as Merge Object Viewer [36] to facilitate the projection of objects onto a Merge Cube [14] into their current environment. This type of AR application is useful to students who designed a 3D object using Tinkercad and wish to view the object in their current environment before uploading it to Level Builder (Video 4, https://drive.google.com/file/d/1hTu_54BD9MkXa8bLj4brcMiG-8vw1p4K/view?usp=sharing). Additionally, the student can observe the object for size and expectations before upload to their custom Level Builder environment.
3.6.3 3D printing services
If the teacher, coach, or parent wants to print the student’s custom 3D object, companies such as MakeXYZ [37] offer services to upload the.stl file, select inexpensive materials, and ship the resulting 3D object to you. The object can be used later with a Vex IQ robot on a physical playfield. Printing services provide several benefits to teachers, coaches, and parents who do not have access to a 3D printer and raw materials. Printing in 3D requires a large block of time, often overnight for one object. The extruder of the printer that melts the raw material filament can be approximately 280° C or 536° F [38], which requires adult supervision. If the roll of filament becomes jammed during printing, it can pull the extruder off the printer and ruin the printed object. Printing services provide access to 3D objects for students in face-to-face, synchronous, or asynchronous learning environments.
The RVW package provides every learner with an opportunity to code in RobotC, practice navigation in pre-packaged challenges, and create custom virtual worlds. The integration of student-created 3D objects into RVW with the option to observe and jury their creation using AR applications such as Merge prepares each student to become a producer of custom programs that transitions well to physical robotics.
4. Transition from virtual to physical robotics
Teachers, coaches, and parents who shepherd learners through the world of virtual robotics will be well-positioned to take the leap into physical robotics. The RVW package has a compiler target for a virtual or a physical robot. The students can compile and download the same program that they developed to navigate their custom Lebel Builder world to a physical Vex robot via a computer-to-robot USB cord. Obstacles crafted from recycled materials and placed on the floor of a classroom, community center, or home provides a workable test environment. It is helpful to create a “game” to have teams of students develop a scenario to have the robot gain “points” as the it navigates a custom, physical playfield. Example of games that this author’s students developed included a home base for astronauts on the Moon and a distribution center for clean water in the aftermath of a natural disaster. Each time the robot accomplished a task using its sensors, the team gained points. It is important to note that teams can share the same physical robots by downloading their program to the robot brain. Sharing the same robots requires teams’ agreement on the “build” of the robot to agree upon the location of the sensors.
5. Conclusion
Virtual robotics provides teachers, coaches, parents, and students with a unique opportunity to achieve a one-to-one ratio of robot to student. Vex VR and Robot Virtual Worlds provide students in face-to-face, asynchronous and synchronous settings with the opportunity to build upon their programming expertise while navigating a virtual robot in packaged and customized challenges.
\n',keywords:"virtual robotics, hybrid teaching environments, TPACK framework, computer-aided design, augmented reality",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/80166.pdf",chapterXML:"https://mts.intechopen.com/source/xml/80166.xml",downloadPdfUrl:"/chapter/pdf-download/80166",previewPdfUrl:"/chapter/pdf-preview/80166",totalDownloads:82,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:1,impactScore:0,impactScorePercentile:0,impactScoreQuartile:0,hasAltmetrics:1,dateSubmitted:"December 3rd 2021",dateReviewed:"December 15th 2021",datePrePublished:"January 22nd 2022",datePublished:"May 18th 2022",dateFinished:"January 21st 2022",readingETA:"0",abstract:"Traditional robotics instruction in face-to-face classrooms, after-school clubs, and independent competition environments align with expensive, physical robot kits shared by students. Students or parent groups often elect themselves because of previous experience, expertise, or perceived technical ability to dominate the physical robotic platforms’ planning, engineering, building, and subsequent programming. This self-elected grabbing of control leaves students who are not regarded as well-positioned to contribute sidelined to observe the self-appointed experts of the group. Virtual robotics platforms provide educators and coaches with the unique opportunity to give every student access to a robot. Each student learns programming, math, and scientific forces that impact robots through simulated physics algorithms. With their customizable virtual environments, virtual robotics platforms such as Vex VR and Robot Virtual Worlds level the playing field. All students can learn, practice, and subsequently contribute to robotics-centered group projects or competitive teams in meaningful ways. This book chapter delineates the strategies to implement virtual robotics in hybrid classroom environments supported by the Technological Pedagogical Content Knowledge (TPACK) framework. Additionally, this chapter reviews how computer-aided design and augmented reality platforms provide students with the opportunity to incorporate 3D objects into virtual worlds.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/80166",risUrl:"/chapter/ris/80166",book:{id:"11196",slug:"new-updates-in-e-learning"},signatures:"Sharon Mistretta",authors:[{id:"437279",title:"Dr.",name:"Sharon",middleName:null,surname:"Mistretta",fullName:"Sharon Mistretta",slug:"sharon-mistretta",email:"cottagetechnology@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Vex VR",level:"1"},{id:"sec_2_2",title:"2.1 Vex VR technological knowledge (TK)",level:"2"},{id:"sec_3_2",title:"2.2 Vex VR content knowledge: science and math (CK)",level:"2"},{id:"sec_4_2",title:"2.3 Vex VR technological content knowledge (TCK)",level:"2"},{id:"sec_5_2",title:"2.4 Vex VR pedagogical knowledge (PK): computational thinking",level:"2"},{id:"sec_6_2",title:"2.5 Vex VR pedagogical content knowledge (PCK)",level:"2"},{id:"sec_7_2",title:"2.6 Vex VR technological pedagogical knowledge (TPK)",level:"2"},{id:"sec_8_2",title:"2.7 Vex VR technological pedagogical content knowledge (TPACK)",level:"2"},{id:"sec_10",title:"3. Robot virtual worlds",level:"1"},{id:"sec_10_2",title:"3.1 RVW technological knowledge (TK)",level:"2"},{id:"sec_11_2",title:"3.2 RVW content knowledge – sensors and geometry (CK)",level:"2"},{id:"sec_12_2",title:"3.3 RVW technological content knowledge (TCK)",level:"2"},{id:"sec_13_2",title:"3.4 RVW pedagogical knowledge (PK) – perseverance rover",level:"2"},{id:"sec_14_2",title:"3.5 RVW pedagogical content knowledge (PCK)",level:"2"},{id:"sec_15_2",title:"3.6 RVW technological pedagogical knowledge (TPK)",level:"2"},{id:"sec_15_3",title:"3.6.1 Level builder custom virtual environment",level:"3"},{id:"sec_16_3",title:"3.6.2 View custom 3D objects in augmented reality",level:"3"},{id:"sec_17_3",title:"3.6.3 3D printing services",level:"3"},{id:"sec_19_2",title:"3.7 RVW technological pedagogical content knowledge (TPACK)",level:"2"},{id:"sec_21",title:"4. Transition from virtual to physical robotics",level:"1"},{id:"sec_22",title:"5. 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Available from: https://www.makexyz.com'},{id:"B38",body:'Simplify 3D. [Internet]. Simplify3d.com. Cincinnati, OH USA; 2019. [cited 2021 Dec 2]. Available from: https://www.simplify3d.com/support/print-quality-troubleshooting/overheating/'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Sharon Mistretta",address:"cottagetechnology@gmail.com",affiliation:'
Johns Hopkins University School of Education, Baltimore, Maryland, USA
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\n
1. Introduction
\n
The purpose of buildings is to protect the occupants from a harsh outdoor climate, but also to provide a comfortable and healthy indoor environment. The latter two objectives are intimately related to building ventilation, i.e. the exchange of indoor air with outdoor air. However, 40% of the total consumption of energy resources in the European Union (EU) can be traced to building use. [1] A large part of the consumption is due to the need to condition the indoor air for the thermal comfort of the occupants, i.e. heating or cooling depending on the outdoor climate. In these situations, exchanging the conditioned indoor air for unconditioned outdoor air obviously raises the energy consumption. On the other hand, striving for more energy efficient buildings without a clear strategy for adequate ventilation is likely to lead to more toxic and hazardous indoor environments. In a wider perspective, the relative projected societal costs for the occupants of a building, compared to the energy use in that building, are probably nine to one. [2] Compromising public health in the name of “energy efficiency” can therefore lead to a considerable economic backlash for society. In a larger perspective, many indoor sources of pollutants in the world have been identified as major causes of premature mortality, e.g. combustion of biomass fuels for cooking, burning incense or mosquito coils and parental smoking. [3, 4] In addition, if the occupants perceive the indoor environment to be unhealthy or uncomfortable, they are likely to take actions (e.g. use air cleaners or increase ventilation flows) that will increase the energy use in buildings. [5]
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After the energy crisis in 1973, new and renovated buildings have been built with increasingly tighter envelopes to stop uncontrolled air exchanges through cracks and leaks in the construction and to improve energy efficiency. In 1974, the “Passivhaus”-concept combined three energy-saving measures: adequate thermal insulation, a tight envelope, and heat recovery into the idea of a building requiring no, or very little, energy use after it was built. [6] After a few serious backlashes in the early days, the building technologies used to achieve energy efficiency in nearly zero energy (NZE) buildings are currently more mature, but the efficiency of the corresponding ventilation strategies have not been given the same attention. There are several examples of inadequate ventilation in NZE buildings. [7] After the EU Energy Performance in Buildings Directive (EPBD) in 2010, [1] stipulating that all new building should meet the NZE requirements, a majority of EU ventilation experts were worried that EPBD would lead to a worse indoor air quality as compared to the current state. [8]
\n
The EPBD is an integral part of the European Green Deal: an action plan to reach a “climate neutral” EU economy. [9] The European Green Deal outlines a more sustainable path for economic and societal development to “transform the EU into a fair and prosperous society, with a modern, resource-efficient and competitive economy”. [9] The European Green Deal addresses many issues: a toxic-free environment; preserving and restoring ecosystems and biodiversity; circular economy; a fair, healthy and environmentally friendly food system; but much focus is devoted to an energy transition to reach zero net emissions of greenhouse gases in the EU by 2050 at the latest. [9] Zero net emissions means that there should be a balance, between the actual emissions of greenhouse gases and the absorption of greenhouse gases by nature (or other processes), in some bookkeeping system like the Emission Trading System. [9, 11] This goal of net zero emissions by 2050 will be legally binding for the member states if the proposal for an EU Climate Law is ratified. [10] Renewable energy sources as well as moving to more energy efficient and sustainable solutions play essential roles in the European Green Deal. [9] The EPBD is the result of the European Commission’s resolve to “rigorously enforce legislation related to the energy performance of buildings”. [9]
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Another issue addressed in EPBD (and its amendments as well as in the European Green Deal) is that 85% of the present building stock in the EU is built before 2001, and most of those buildings are not considered energy efficient. [12, 13] More importantly, at the current rate of renewal (1%), 85–95% of the buildings that will be standing in 2050 are already built. [9, 12, 13] Increasing the rate of renovation of the existing building stock to NZE standard should therefore be strongly encouraged in order to reach “climate neutrality”. [12] Recently, the European Commission also proposed to triple the building renewal rate to 3% coupled with an even more aggressive renovation strategy to kick-start the EU economy after Covid-19. [14]
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Adapting existing buildings to NZE are much more complex tasks than to build a NZE-building from scratch. It requires a considerable knowledge-base of old building techniques, old installations, and the consequences that may arise when NZE technologies are retrofitted to these older structures. In addition, 25% of the existing buildings are historic and will require respect for aesthetics, conservations principles and architectural craftsmanship. [15] In fact, the craftsmanship in many older buildings, although non-historic, deserve the same respect. However, the guiding principle of EPBD: “Energy efficiency first”, clearly states that the energy aspect will be given a high weight in a decision conflict. [14] Even though the EPBD states that indoor environments should be healthy or that cultural heritage should be safeguarded and preserved, it is obvious that these incentives will be pushed towards the minimum legal requirements when they are in conflict with the efforts to achieve energy efficiency. [12]
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In the decision conflict between energy efficiency in buildings and adequate ventilation, EPBD has put an increasing pressure on governmental agencies in the member states to lower the standards for ventilation and air quality in existing building codes and ventilation regulations (see discussion in Section 2.3). [12] From a ventilation perspective, the standards for air quality should rather become more stringent when the buildings become tighter. There is a balance between the existing ventilation regulations in a country and the air leakages in its building stock because these air leakages contribute to the indoor ventilation, albeit uncontrollably. Legislative regulations on the performance of ventilation systems are also important counter balances to the quest for energy efficiency in buildings. The pressing question is what must, or should, be regulated to ensure an adequate indoor environment that is comfortable and healthy for the occupants. The aim of Section 2 of this chapter is to investigate possible answers to this question and put them in a wider perspective.
\n
Another effect, of the coming EPBD renovation wave, is probably that the number of buildings with natural ventilation systems will decrease. [8] Many of the older buildings have some kind of natural ventilation system, whereas most new buildings have mechanical ventilation systems. Because heat recovery is such an important ingredient in NZE buildings, mechanical ventilation systems will be chosen more frequently in spite of the fact that some of the energy recovered will be offset by the energy used by the fans. In a milder climate, a balanced mechanical ventilation system with heat recovery will probably save very little energy and would be costly from a life cycle perspective. [16] Fully functional older buildings with natural ventilation systems will perhaps be retrofitted with mechanical ventilation systems and lose some of their aesthetical or cultural heritage values. On the other side of the spectrum, if such a building cannot satisfy the building code regulations, it may be declared unfit for use and demolished. [17] It would naively appear that natural ventilation, where natural driving forces for air flows are used to ventilate the building, is a more sustainable solution than mechanical ventilation, where electrical energy is used to power fans that generate air flows with high pressures. While even the older natural ventilation systems have many advantages regarding occupant satisfaction, they have some difficulties to compete with the mechanical systems when it comes to predictability, controllability, and heat recovery. [16, 18] Nevertheless, natural ventilation systems are considered the more sustainable options in many research initiatives. [19, 20, 21, 22]
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From this perspective, a revival of the use of natural ventilation systems, rather than the projected decline outlined above, would be desired. There are a number of new promising innovations and old, forgotten, know-how is rediscovered, e.g. wind towers, evaporative cooling, solar chimneys and box windows to name a few. [23] The thermal performances of many ancient buildings, with natural ventilation systems, are far superior to many modern buildings, with mechanical ventilation systems. The list could probably be made very long, but some selected examples are: the “baadgir” in the Dolatabaad garden in Yazd, Iran, that uses several of the mentioned techniques [24]; the Villas at Costozza, Italy, use cool air from nearby caves; the Palazzo Pitti in Florence, Italy, use the cooler air from the Boboli gardens and further cool it underground; the cloister Palazzo Marchese in Palermo, Italy, cool the air underground and augment the effect using underground rivers. [23] Natural ventilation systems thus display many good properties, but their drawbacks will prevent them from fulfilling all ventilation needs. The future of sustainable ventilation will probably be centered on optimal combinations of natural and mechanical ventilation techniques instead, i.e. hybrid ventilation systems.
\n
While there are many good modern examples of buildings with natural and hybrid ventilation systems, [21] there are at least three important hurdles to cross. One hurdle is that the local building codes and the ventilation regulations in many instances are written with mechanical ventilation systems in mind, which makes it difficult for natural ventilation systems to comply. The second hurdle is that architects and builders may consider natural ventilation systems as a more risky option than mechanical ventilation systems. Describing the low pressure systems of natural ventilation is inherently more difficult than to describe the high pressure systems of mechanical ventilation. The most diligent Computational Fluid Dynamics (CFD) description of natural ventilation can be completely transformed when occupants are moving or closing doors. To cross this hurdle, better tools for design of larger buildings with natural or hybrid ventilation are needed. [16, 25] The third hurdle is urbanization. Many effects of urbanization: pollution, “heat islands”, and wind obstruction, favor the use of mechanical ventilation systems. [20] Ventilation requires the outdoor air to be healthy, otherwise it must be cleaned at a considerable cost of energy. There are many issues concerning natural ventilation to discuss, but in this chapter, there is only a brief discussion (at the end of Section 2) on the hurdles for natural ventilation systems in the local building codes and ventilation regulations.
\n
\n
\n
2. Requirements for ventilation
\n
The purpose of building ventilation is to provide a healthy and comfortable environment for the occupants. However, the human perception of the conditions that constitute a healthy and comfortable environment depends on many factors. [26, 27] The section starts with a historical perspective on the evolution of different ideas concerning the relationship between ventilation and human health and comfort. This is followed by a theoretical treatment of ventilation that hopefully will give the reader some insights into how a good ventilation system performance may be specified. The section finishes with a critical examination of how legislative regulations of ventilation are specified and some suggestions on how it may be modified to facilitate the use of natural and hybrid ventilation systems.
\n
\n
2.1 A short history of ventilation and health effects
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The notion that “bad air” leads to health problems has a long history. The name for the disease malaria is derived from the Italian mala aria that literally means “bad air”. The origin of the word, used in the sense that the surrounding air in wet, and swampy locations is a cause of disease, can be traced back as far as the ancient Greeks and Romans. Another word for “bad air”, first used in 1655, is “miasma” that is derived from the Greek minainein “to pollute”. In the advent of urbanization in the late eighteen hundreds, medical doctors observed that diseases were more common in the poorer areas of cities. These areas were often overcrowded and situated in unsuitable damp areas. Two battling theories were put forth: the miasma-theory preached that diseases were caused by locally generated emissions (or antropotoxins); the contagium-theory preached that diseases were caused by poisonous particles that were transferred between humans. The father of ventilation science, Max von Pettenkofer, was a front figure for the miasma-theory and suggested increased air flows into the dwellings to remove the locally generated emissions. [28] A leader of the contagium-theory (from Latin contagio “contact”), i.e. the father of clinical microbiology Robert Koch, instead suggested measures to limit the spread of the supposed contagium: isolation, quarantine, and border control [29]. The scientific battle was infected by political undertones. The latter measures were unpopular among the trade-friendly industrialists that were politically opposed to the more isolation-friendly local land owners at this time. [30] It was a heated battle, where von Pettenkofer scored some political points when he in 1892 drank a cocktail of cholera bacteria without catching the disease. [31] He was probably immune. [30] By 1900, bacteria were firmly established as the contagium-vehicle. It was a landslide victory to the point where most of von Pettenkofers academic contributions were practically erased. He continued to maintain that miasma ought to be an aiding factor in the spread of diseases, until he killed himself with a pistol head shot in 1901. [30]
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Today this issue may not be altogether black or white. Ventilation and overcrowding have been shown to indirectly influence the spread of diseases. [32] It becomes difficult to conduct good scientific work when political polarization and strong emotions enter the scientific discussion. The historical lessons are not so easy to adopt, as evidenced by more recent heated scientific battles such as global warming or the present Covid-19 battles (see for example [33]).
\n
A remaining miasma-related question concerned the rising sense of discomfort experienced by humans in overcrowded rooms. It was well known at the time that enclosing people in a room with very little ventilation lead to symptoms like headache, nausea and dizziness. In severe cases it could even lead to unconsciousness and death. The father of chemistry, Antoine Lavoisier, in cooperation with Laplace had demonstrated in 1783 that the cause of death could not be attributed to lack of oxygen molecules, but probably to an excess of carbon dioxide [34]. Exhaled air of humans contain approximately 44 000 ppm of metabolic CO2. [35] This means that the excess CO2 in the blood cannot be expelled at exposures to CO2 concentrations above that. Accumulation of CO2 in the blood cause the pH to progressively decrease, and in turn this leads to a series of bodily malfunctions. Death by drowning is caused by the increasing acidity of the blood (acidosis) as the CO2 concentration accumulates and not by too few oxygen molecules in the lungs. Exposure to 20 000 ppm CO2 leads to headache and shortness of breath after a few hours. Exposure to 70 000–100 000 ppm CO2 leads to unconsciousness after a few minutes. Exposure to >170 000 ppm CO2 causes death in humans within one minute from first inhalation. [36] To illustrate how high these concentrations are: a human hermetically enclosed in a 2.5 m3 box would probably still be barely conscious after 24 hours, assuming an exhalation rate equivalent to 0.018 m3 h−1 pure CO2. [35] Pettenkofer had dismissed CO2 as the cause of diseases, but had developed simple methods to measure it and suggested that the concentration of CO2 could be used as a proxy for the supposed antropotoxins. While investigating public venues in Munich, he had found values as high as 7100 ppm CO2. [31] Pettenkofer noticed that human odours were clearly perceptible around 1000 ppm CO2 (now known as the Pettenkofer number) and proposed this as a “safe” target to strive for.
\n
The final blow to the miasma-theories was dealt by Carl Flügge in 1905. [37] He devised a series of experiments enclosing humans in glass boxes. The air supply to the breathing zone and to the rest of the box could be controlled separately, as well as other parameters such as temperature and relative humidity. Among other parameters, Flügge varied the odors in the air supply, e.g. air from sewage etc. He found that only the appetite of the subjects was adversely affected, otherwise the subjects adapted to the foul smells. The only “contaminant” that had any adverse effect on the comfort of the subjects was temperature. [38] These experiments totally obliterated the contemporary ventilation philosophy and turned it on its head. There appeared to be no evidence for regulating ventilation from a chemical perspective, as long as the physical parameters (like temperature and relative humidity) were within acceptable comfort-limits. The purpose of a window quickly changed from letting fresh air in to letting heat out. However, some practitioners argued (on the basis of proven experience) that it might be wise to retain some ventilation flows into buildings. [30] It took several years before new ventilation standards were proposed. [38]
\n
The need for ventilation, and the chemical perspective, slowly crept back via odor-control. The human nose is in fact very sensitive to certain indoor odors. From an evolutionary perspective, it appears to have been advantageous for humans to judge a dwelling by its smell. While the human nose may adapt, people were not comfortable with entering a room with foul smells. This angle provided an incentive for new and fruitful experiments on ventilation requirements. In 1936, Yaglou et al. [40] extended some experiments performed by Lehmberg et al. [41] the year before. They conducted a series of experiments on a group of people to determine their subjective acceptance of the perceived air quality upon entering a test chamber. By varying a number of parameters in the test chamber, Yaglou et al. demonstrated a correlation between the degree of acceptance, the pollution load, and the ventilation air flow into the test chamber. Their results were immediately, but cautiously, adopted by the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE). [38]
\n
\n\nFigure 1\n (inspired by Awbi [35]) shows a compilation of the ventilation requirements historically recommended by ASHRAE, including its predecessors. [38] The news of Flügge’s experiments hit like a bomb when it was presented at the ASHRAE 1911-meeting. [30] All previously accepted ventilation requirements were for all practical purposes under reevaluation until 1936. [37] (The reason why the old high ventilation requirements were maintained for some time (as shown in \nFigure 1\n) had to do with the fact that the previous requirements were included in many state laws. [37]) Yaglou also studied the ventilation requirements in relation to environmental tobacco smoke (ETS). [42] As non-smokers are very sensitive to any remaining smoke odor, he found that very high ventilation rates were required to reach acceptance (from them). Smoking was very common at the time. In 1965, 43% of U.S. adults were regular smokers. [43] As health concerns in U.S.A. regarding smoking and indoor ETS were starting to be officially recognized from 1964 and onwards, the question of ventilation requirements started to become a hot topic again. [43] In the ASHRAE Standard 62 (1981), two ventilation requirements for offices were proposed (shown in red in \nFigure 1\n). The lower one applied to offices without smokers and the higher one to offices where smoking was allowed. This was immediately perceived as a business threat by the tobacco industry. A memorandum circulated at Philip Morris concludes that adopting and enforcing this standard would at least double the maintenance costs for a workplace that allow smoking. [44] In the end, neither the American National Standards Institute (ANSI), nor the Building and Official Code Administrators adopted the 1981 standard as it was considered “controversial”. Therefore, the standard was never enforced. In the next “revised” standard that was accepted by ANSI, i.e. ASHRAE 62 (1989), the lower ventilation requirement was retained and moderate smoking was allowed. [44] The tobacco industry succeeded to block the enforcement of new ASHRAE standards until 2000. [44] The recent decreases in the recommended ventilation requirements, shown in \nFigure 1\n, can probably also be interpreted as energy-saving measures.
\n
Figure 1.
Ventilation requirements recommended by ASHRAE and predecessors. From 1936 and forward (grey) the required flow per person in a standard office is shown. The earlier values (blue) are per room. The red shows the unadopted ASHRAE 62 (1981).
\n
Note that the lower limit proposed in ASHRAE Standard 62 (1981) (red in \nFigure 1\n) essentially is a revocation to the lowest ventilation requirements proposed in 1836. The guidelines for ventilation requirements are in fact influenced by a number societal parameters. By this time a fair amount of the newer buildings were mechanically ventilated. In Sweden, mechanical ventilation was primarily used in industrial buildings before 1947, but the invention of the less noisy radial fans opened the market for ventilating other buildings. [30] When the energy crisis hit in 1973, the energy used for ventilating buildings suddenly became a liability. The lowered ventilation requirements in the standard of 1981 can therefore be understood in terms of the corresponding decrease in the energy use for the fans in mechanical ventilation and for heating (or cooling) the air supplied. The air supplied into dwellings was further reduced by efforts to reduce air leakages through the building envelope, particularly in the Nordic countries. After a while, reports of occupant discomfort started pouring in. It appeared that up to 30% of the newly built office buildings had an unusually high amount of complaints. In some cases, causal relations to ill-health could be found: e.g. in the use of new materials, moisture damage, or improperly performed building techniques. [39, 45] A large group of diffuse symptoms such as headache, fatigue, lack of concentration and irritation of the skin and mucous membranes remained unexplained. In 1984 the WHO Regional Office for Europe collectively referred to these symptoms as a new medical diagnosis: Sick Building Syndrome (SBS). [46] The onset of constructing tighter building envelopes seemed to be a likely cause. This sparked a renewed research interest in finding the optimal ventilation requirements.
\n
Fanger and coworkers repeated the Yaglou experiments, but with a much larger sample size in the 1980s. [47] In addition, Fanger attempted to quantify the perceived emissions from the human body and suggested a new subjective, relative unit: olf, the emission rate of air pollutants (bio-effluents) from a standard person (from Latin olfactus “smelling”). The idea of relative units related to standard people came from previous studies of thermal comfort. Fanger’s standard person was characterized as a sedentary white-collar worker (or student) aged 18–30 with a hygienic standard corresponding to 0.7 baths/day and changing underwear daily. Deodorants were used by 80% and some were smokers, but the proportion is not specified. By varying the test chamber ventilation rate (q) in a cohort study of 1000 people judged by 168 “judges” (probably from the same cohort), Fanger found the following correlation (r\n2 = 0.79 and valid for q ≥ 0.32 L s−1 per person, or olf):
where PD is the percent dissatisfied “judges”, q is the ventilation rate (L s−1) per person, L is liters [dm\n3\n] and s is seconds. \nFigure 2\n shows the correlation curve given by Eq. (1). These results corresponded well with contemporary measurements. [48] In field studies in 15 office buildings, using a similar experimental method, Fanger et al. found that the sources of disagreeable indoor air pollutants were definitely not limited to human bio-effluents. The olf-equivalents attributed to other indoor sources were: indoor materials, 1–2 olf;: the mechanical ventilation system itself, 3 olf;: tobacco smoking, 2 olf. [49] These and other studies highlighted the necessity to control all indoor air pollution sources in order to reach an acceptable indoor environment in terms of perceived air quality. In a large study of school workers by Smedje et al. [27], it was also shown that their perceptions of the air quality at work were confounded by personal, psychosocial and domestic factors. In short, studying human perception is complicated by many factors and pose some challenges on experimental design.
\n
Figure 2.
Fanger’s correlation between the required ventilation rate per person (or olf) and the percent dissatisfied judges upon entering the test chamber. The numbers in the figure correspond to the required ventilation rates for the 10%, 20%, and 30% levels of the percent dissatisfied judges.
\n
No single factor causing SBS has yet found any consensus. Sometime after its last official document on SBS in 1995, WHO discontinued the use of SBS as a medical diagnose. A contemporary search on the homepage of WHO yields zero hits. However, that a correlation seem to exist between SBS-related issues and some ventilation parameters receives some consensus in the multidisciplinary field concerned with healthy buildings. In 2001 [50], Jan Sundell managed to convene several European principal researchers in the field to search for consensus on the connection between ventilation and health. There are few well-designed studies that adequately account for all the multiple factors that are encountered when assessing indoor environments. Out of the selected 105 scientific papers in peer-reviewed journals only 30 were deemed conclusive for the question at hand. The consensus statement include the conclusions that there is:
\n
“a strong association between ventilation and comfort (as indicated by perceived air quality) and health (as indicated by SBS symptoms, inflammation, infections, asthma, allergy, short- term sick leave). … also indicates that there is an association between ventilation rate and productivity (as indicated by performance of office work).” [50].
\n
A similar exercise, with a larger geographical spread of the researchers, was initiated by Jan Sundell and Hal Levin in 2010. Many conclusions were similar, but it should be noted that the panel members were divided as to whether the association between ventilation and health outcomes (excluding SBS) was strong or simply suggestive. [51] Both studies conclude that air change rates (see Section 2.2) below 0.5 h−1 leads to increased infestations of house dust mites in the Nordic countries. The latter was deemed important, since there is a plausible link between exposures to the feces of house dust mites and the prevalence of asthma and allergic rhinitis. [52]
\n
This concludes the selective short history of ventilation. The idea that ventilation promotes health by removing harmful substances has been a lingering and recurring theme. The effects of indoor exposure to harmful substances are typically studied as dose–response assessments. [39] The relevant exposure dose is the concentration of the harmful substance in the indoor air and the responses are the measureable effects on humans. When adverse health effects are established, the exposures of those harmful substances are usually regulated or their use simply forbidden. [39] This also means that, in principle, there should be no known harmful substances to be removed by ventilation in the indoor environment. As will be evident in Section 2.3, most guidelines for ventilation requirements are based on perceived indoor air quality, and not health, criteria.
\n
Nevertheless, there is a case for using ventilation as a precautionary measure to prevent adverse health effects caused by the indoor environment. There has been a significant increase in the number of chemicals never before encountered in the indoor environment, particularly in the last fifty years. [43] Today, literally thousands of chemicals are present in the indoor air (see for example [53]). Since most studies of dose–response assessments focus on one single substance at the time, the effects of mixtures of substances are largely unknown. [54] In addition, a majority of these new indoor chemicals have not been studied for health effects. When a harmful substance is forbidden, it is often substituted for new substances with (as yet) unknown health effects. In light of these known unknowns, it may be prudent to specify some minimum ventilation requirements as a precautionary health measure.
\n
\n
\n
2.2 Some insights from the theory of ventilation
\n
Before critically examining the existing guidelines for ventilation requirements a few theoretical explanations of the salient points are needed. Consider first the One-zone model as shown in \nFigure 3a\n. The flows of air supply to, and air exhaust from, the zone are equal. An air pollutant is emitted at a constant rate into the zone. The assumption for now is that the zone is fully mixed, i.e. the concentration of air pollutant is exactly the same everywhere in the zone. The validity of this assumption, and other assumptions, will be discussed below.
\n
Assuming that the initial concentration of air pollutant is zero and no air pollutant enters via the air supply (\n\n\nc\n0\n\n=\n\nc\next\n\n=\n0\n\n), the mass balance equation for the air pollutant in the zone is
\n
Figure 3.
Simple zone models. (a) One-zone model. (b) Two-zone model.
where V [m3] is the volume of the zone, \n\n\nm\n·\n\n\n [kg h−1] is the constant emission rate of air pollutant, \n\n\nc\nt\n\n\n [kg m−3] is the concentration c of air pollutant in the zone at time t [h], and Q [m3 h−1] is the rate of air flow into and out of the zone. (The conversion factor between Q [m3 h−1] and q [L s−1] is \n\nQ\n=\n3.6\nq\n\n). The steady state solution of Eq. (2) is obtained when a constant equilibrium concentration is established in the fully mixed zone. Setting the left hand side to zero gives
\n
\n\n\nc\n∞\n\n=\n\n\nm\n·\n\nQ\n\n\nE3
\n
where \n\n\nc\n∞\n\n\n is the constant equilibrium concentration at \n\nt\n=\n∞\n\n. This is an important result. It appears that, given a constant emission rate of an air pollutant, it is the ventilation rate that determines the final concentration of air pollutant in the zone (i.e. the exposure to the air pollutant). However, this conclusion is only valid provided that the zone is completely mixed at all times.
\n
For the case of a hermetically closed zone, i.e. when \n\nQ\n=\n0\n\n in Eq. (2), it can be solved by integration to yield
\n
\n\n\nc\nt\n\n=\n\n\nm\n·\n\nV\n\nt\n.\n\nE4
\n
\nEq. (4) shows that the air pollutant concentration will increase linearly with time in a hermetically closed zone. Note that the volume of the zone (V) buffers the rate of concentration increase in the zone. The larger the volume, the slower the rate of increase of the air pollutant concentration in the zone.
\n
Another illustrative one-zone case is obtained by allowing an initial concentration \n\n\nc\n0\n\n\n of the pollutant in the zone at \n\nt\n=\n0\n\n and assuming that \n\n\nm\n·\n\n=\n\nc\next\n\n=\n0\n\n. Solving for the concentration gives
where the hourly air change rate (ACH) for a completely mixed zone is defined as \n\nN\n=\nQ\n/\nV\n\n. Eq. (5) means that for any temporary emission of air pollutant in the zone, its concentration will decay exponentially with time. The rate of decay is gauged by the air change rate N. A higher air change rate means a faster decay.
\n
The simple One-zone model of ventilation presented above has two main problems: (i) Emission sources are not evenly distributed in the zone volume. They are local and confined to surfaces, objects or humans. (ii) Complete mixing of a zone is difficult to achieve. Both points can be illustrated with a simple Two-zone model, originally proposed by Etheridge and Sandberg [55], as shown in \nFigure 3b\n. In the Two-zone model, emission sources are allowed to be slightly more local and the required mixing air flows are made slightly more explicit in terms of the inter-zonal air flows. Inter-zonal air flows are given as \n\nβQ\n\n, so when \n\nβ\n=\n1\n\n the inter zonal air flows have the same magnitudes as the supply and extract air flows. For simplicity, complete mixing of both zones are assumed. The mass balance equations in each zone for the case \n\n\nc\next\n\n=\n\nc\n10\n\n=\n\nc\n20\n\n=\n\n\nm\n·\n\n1\n\n=\n0\n\n becomes
Note that the steady state result for c1\n in Eq. (7) is the same as for the completely mixed One-zone model in Eq. (3). If nothing is known about the distribution of concentrations within the zone, the proper interpretation of steady state in Eqs. (2) and (3) is that the emitted amount equals the exhausted amount and that the accumulation of air pollutant in the zone has stopped. The interpretation that the concentration is constant in the zone is not correct. Unless, of course, complete mixing is established by other measurements. In general the concentrations are not equal, as is evident in \nFigure 4\n where the dimensionless quotient \n\n\nc\n2\n\n/\n\nc\n1\n\n\n of the steady state concentrations from Eq. (7) are plotted against β. Note that c2\n approaches c1\n very slowly as β increases in \nFigure 4\n. In order to reach complete mixing the inter-zonal air flows must be much larger than the supply and extract flows. In experiments where complete mixing of the whole zone is important, e.g. using the decay in Eq. (5) to measure the air change rate using tracer gases, several extra fans are employed to come as close as possible to the ideal case of complete mixing. It is also clear from \nFigure 4\n that the concentration of air pollutant in the lower zone rises very quickly as β decreases below unity. From an exposure point of view, it is problematic that concentrations of air pollutants may differ considerably within a room when mixing is incomplete.
\n
Figure 4.
Increase in the relative concentration in the lower zone (2) as a function of the interzonal flows. When β = 1 the interzonal flows are equal to the air supply.
\n
The special case when the fresh air from the supply flow never enters the lower zone and directly exits by the extract is called ventilation short-circuiting. In this case, β is zero and the lower zone essentially behaves as a hermetically closed zone (Eq. (4)) and the concentrations of all air pollutants emitted in the lower zone rise without bounds. To be fair, ventilation systems are designed to deliver fresh air to occupants and complete short-circuiting is rare. However, poorly designed systems do exist. One example is shown in \nFigure 5\n. Typical situations when short-circuiting may occur are: if inlet and exhaust devices are close to each other; if there are obstacles in the flow path of a mechanical ventilation air inlet; if the air supplied is warmer than the air in the room and the extract is near the roof.
\n
Figure 5.
Retrofit of cooling beam (with attached light fixture) leading to a high degree of ventilation short-circuiting. Air supply device to the left and air exhaust to the right.
\n
In a more general theoretical approach, allowing for non-homogeneous concentration distributions in the zone, all possible paths of a very small package of air from the inlet to the outlet are considered (see Etheridge and Sandberg [55] for a complete treatment). A long and tortuous path for the package or air will result in a long residence time for the package within the zone, whereas a short path corresponding to a ventilation short-circuit would lead to a very short residence time. At the outlet, packages of air escaping the zone in every instance of time will represent many different residence times. At steady state, in a similar manner as in Eqs. (3) and (7), the distribution of residence times will converge to a constant average residence time \n\n\n\nτ\nr\n\n\n\n for the air packages. The average residence time can also be interpreted as an average age of the air packages exiting the zone, if the age of an air package is set to zero as it enters into the zone through the inlet. This concept of ages of air packages is useful when examining the interior of the zone.
\n
The simple process of plug (or piston) flow illustrates the age concept well. It is the most efficient method to ventilate and is used in so called “clean rooms”. The idea is to achieve a laminar flow by supplying slightly colder air from the roof and letting it fall vertically to the floor where it is extracted. Ideally, all air packages entering from the whole area of the roof fall at the same speed and reach the floor simultaneously. This means that all air packages have exactly the same residence time in the zone. It is easy to show that the residence time only depends on Q and V, regardless of the shape of the zone, and is given by
where the nominal time constant of the ventilation system \n\n\nτ\nn\n\n\n is defined. For plug flow the average residence time is equal to the nominal time constant. Since the air packages follow the shortest route from the roof to the floor in plug flow, the nominal time constant can be interpreted as the shortest possible residence time. It is also easy to determine the local age of the air packages in the interior of the zone. It must increase linearly from age zero at the roof to an age equal to the residence time at the floor. Consider an arbitrarily small volume element within the zone. It will contain many air packages with ages that vary linearly with height. The local mean age of air \n\n\nτ\n¯\n\n\n is defined as the average age of the air packages within the small volume element. The local mean age of air can be interpreted in terms of how well the ventilation system delivers fresh air to the volume element. As the packages of air enters the zone, they start to equilibrate by diffusion with the concentrations of contaminants in the local environment and start to become less fresh. The older the air, the less fresh it is. Now let the volume element be as small as one package of air. The average local mean age of air with respect to the entire zone must then be equal to the local mean age at half the height. Think of a process where all volume elements with a low age above the middle height can be paired with volume elements with a high age below the middle height so that their average is exactly the local mean age of air at half height giving
This result can be generalized since the residence time and the local mean age of air of an arbitrary path of the air packages are related by
\n
\n\n\nτ\ni\n\n+\n\nτ\nrl\n\n=\n\nτ\nr\n\n\nE10
\n
where τr\n is the residence time of the path, τi\n is the time already spent in the interior of the zone (i.e. the local mean age of air of the air package) and τrl\n is the residual life time until the air package exit the zone. This is obviously valid for all paths and all air packages will eventually complete their paths to the exit. It will therefore always be possible to pair air packages (with the same residence time), so that their average local mean age is exactly half the residence time. Taking the average of all possible paths, a generally valid relation is given by
Note that the averages of the local mean age of air over all paths or over the zone space give the same results.
\n
Since no other ventilation process can be more efficient than plug flow, the average local mean age of air for other ventilation processes cannot be lower than that for plug flow. It therefore seems natural to assign a 100% air change efficiency to plug flow and consequently define the general air change efficiency in a zone as
For the case of complete mixing, the paths of all air packages should reach any volume element within the zone with the same probability. Complete mixing may also be viewed as a process where all volume elements in the zone are instantaneously considered identical at all times. All volume elements have identical characteristics, such as the same concentrations of molecules and the same local mean age of air. Air entering through the inlet will therefore, in theory, simultaneously enter all volume elements. Within each volume element, air packages with increasing ages will continue to accumulate until the steady state is reached and the local mean age of air stays constant. In analogy, the mass balance given in Eq. (2), describes how a contaminant is accumulated in each volume element until a steady state concentration is reached. Since the mixing conditions are the same, the accumulation of ages and of concentration, respectively, follow the same time evolution. Solving for ct\n in Eq. (2) gives
where Eqs.(3) and (8) were used. In the field of statistics, \n\n\nc\nt\n\n/\n\nc\n∞\n\n\n is an example of a cumulative distribution function. By analogy, it is also the cumulative distribution function for the ages of the air packages. A probability distribution function is obtained by taking the time derivative of the cumulative distribution function. Thus, it is evident that, for a completely mixed zone, the ages of the individual air packages accumulated within a volume element at steady state are exponentially distributed according to
Now the average local mean age of air for a volume element (and for the whole zone) can be evaluated to τn\n. This gives the following relations for a completely mixed system
The average air change efficiency of a mixing ventilation system is at best 50% as compared to plug flow. In analogy with the nominal air change rate N (or ACH) being given as the inverse of the nominal time constant τn\n as
\n
\n\nN\n=\n\nQ\nV\n\n=\n\n1\n\nτ\nn\n\n\n,\n\nE16
\n
An effective local air exchange rate of the zone can be defined as
\n
\n\n\nN\neff\n\n=\n\n1\n\n\nτ\n¯\n\n\n\n\nE17
\n
where Neff\n is the effective air exchange rate and note that the local mean age of air average is spatial and taken over the zone. It can be interpreted as the local ability of the ventilation system to dilute contaminants with fresh outdoor air in the point p. This an important property from an exposure viewpoint.
\n
The aim of the above theoretical exercises for two mixing models is mainly to introduce the concept of local mean age of air and its properties. The fact that it is a local property that can be determined experimentally by tracer gas techniques [55] means that interior points of any ventilated zone can be characterized by it. In particular, in means that the distribution of fresh air to the occupied volumes of a zone can be tested.
\n
The insights from this subsection can now be summarized. It has been shown that requiring a specific ventilation rate is not a guarantee for good performance of a ventilation system. The supplied air must also be distributed efficiently and this capacity should be evaluated. Possibilities for ventilation short-circuiting should be eliminated. Finally, a large zone volume can be a strategy to prevent build-up of concentrations from transient sources of air pollutants.
\n
\n
\n
2.3 A critical examination of guidelines for ventilation requirements
\n
Most of the contemporary legislative guidelines for ventilation requirements are based on criteria for perceived air quality, as concluded in Section 2.1. For more than 20 years, the basic guidelines in the U.S.A. (and also in Europe) have been based on the recommendation that no more than 20% of the occupants should be dissatisfied with the perceived indoor air quality. [56] Nevertheless, the adaptation of the human nose adds a dimension and there is a difference between the philosophy in Europe and the U.S.A on how perceived air quality should be measured. The guidelines in Europe (following Fanger et al. [49]) are based on the perceived air quality as judged by an un-adapted visitor to the room, whereas the guidelines in the U.S.A. (ASHRAE) are based on the perceived air quality by a judge that has been allowed to adapt to the room air for 15 minutes. [5] The American guidelines therefore recommend lower ventilation rates than the European guidelines at the same level of dissatisfied judges. [5]
\n
Comparison of the work place ventilation rates required per sedentary person in \nTable 1\n (i.e. 7 L⋅s−1/person) with the ventilation rates given in \nFigure 2\n, show that The Swedish Work Environment Authority appears to follow the European philosophy in the old, [57] as well as in the new, guidelines. [58] In line with the findings of Fanger et al. [49], many guidelines assume that all other indoor emissions of pollutants (e.g. from building materials and human activities, such as smoking, cleaning, and cooking) should be added to the emissions of bio-effluents from the occupants. All these emissions are lumped into a floor-area-based emission rate. The total required ventilation rate is then the sum of two contributions as shown in Eq. (18).
\n
\n
\n
\n
\n
\n\n
\n
\n
FoHMFS 2014:18
\n
AFS 2009:2
\n
AFS 2020:1
\n
\n\n\n
\n
Air supply/person
\n
≥ 4 L⋅s−1\n ≥ 7 L⋅s−1 (schools)
\n
≥ 7 L⋅s−1\n
\n
≥ 7 L⋅s−1\n
\n
\n
\n
Air supply/m2\n
\n
≥ 0.35 L⋅s−1\n + 0.35 L⋅s−1 (schools)
\n
+ 0.35 L⋅s−1\n
\n
+ 0.35 L⋅s−1\n
\n
\n
\n
Air change rate
\n
≥ 0.5 h−1\n
\n
\n
\n
\n
\n
CO2 concentration
\n
Normally < 1000 ppm
\n
Normally < 1000 ppm
\n
Normally < 1000 ppm
\n
\n
\n
Air change efficiency
\n
\n
≥ 40 %
\n
≥ 40 %
\n
\n\n
Table 1.
Values are extracted from the official Swedish guidelines for ventilation requirements and air quality. FoHMFS are the ventilation guidelines issued by The Public Health Agency of Sweden. [59] AFS are the old [57] and the new guidelines (valid from 1 January, 2021) [58] issued by The Swedish Work Environment Authority. The +-sign signifies that the required air supply per m2 must be added to the air supply per person.
where qtot\n is the total required room ventilation rate [L⋅s−1], np\n is the number of occupants, qp\n is the required ventilation rate per person [L⋅s−1/person], A is the room area [m2], and qA\n is the required ventilation rate per square meter [L⋅s−1⋅m2]. The required qA\n in \nTable 1\n are based on a room with very low emitting materials and no smoking. The Pettenkofer number (1000 ppm CO2) can also be recognized in the guidelines in \nTable 1\n. However, the lowest required qp\n (4 L⋅s−1/person) from The Public Health Agency of Sweden [59] can only keep the CO2 concentrations below 1500 ppm in most realistic scenarios. [60] The Public Health Agency of Sweden is the only government agency recommending a specified air change rate of 0.5 h−1. [59] Note that the floor area based ventilation rate 0.35 L⋅s−1⋅m2 corresponds to an air change rate (N) equal to 0.5 h−1 if the room height is 2.5 m (a common room height in the Swedish building stock). While there are common elements between the required ventilation rates in \nTable 1\n, it is clear that the more generally valid recommendations from The Public Health Agency of Sweden prescribe lower ventilations rates than the recommendations from The Swedish Work Environment Authority that are valid only in nonresidential buildings.
\n
There are mutual dependencies between the ventilation rates presently required by government agencies and the properties of the existing building stock. [8] If the building stock can be shown to cause health problems that can be traced to inadequate ventilation, then the government agencies will try to improve the situation by requiring higher ventilation rates. On the other hand, if air leakages through the building envelopes provide ample contributions to the ventilation of the building stock, in addition to the controllable ventilation rates, then the required ventilation rates need not be as stringent because the total ventilation rate will be sufficient anyway. The point here is to highlight plausible dependencies on average, even though there may be a wide spectrum of properties in the building stock. Thus, changes in the properties of the building stock will lead to changes in the ventilation requirements recommended by government agencies.
\n
The EPBD objective to transform the building stock to NZE- buildings with tighter building envelopes should, with the above logic, lead to a more stringent requirements for ventilation rates. [8] However, as mentioned in the Introduction, the “energy efficiency first” principle in EPBD [12] pushes other incentives towards their minimum legal limits when they are in conflict with the efforts to improve the energy performance of buildings. Maintaining a good indoor air quality by ventilation is such an incentive, and therefore ventilation rates will be pushed towards their minimum legal limits. As a consequence, in the coming EPBD transformation of the building stock, the minimum legally required ventilation rates play a critical role as counterbalances to prevent a decline in indoor air quality. The required ventilation rates will probably need to be increased to maintain the present levels of indoor air quality in the building stock.
\n
It is therefore doubly worrying that the ventilation requirements in the standards on the European level recently have been lowered as shown in \nTable 2\n. For example, in a standard 10 m2 office for one person, the required ventilation rate (qtot\n) is lowered by 43% from 10.5 L⋅s−1 in the old guideline CEN-EN15251:2006 [61] to 6 L⋅s−1 in the new guideline CEN-EN16798:2019. [62] The change corresponds to recommending 30% dissatisfied un-adapted judges in the new guidelines as compared to 20% in the old guidelines. The guidelines in the European Standards provide the “floor” upon which the legal requirements of the member countries rests. Lowering the required ventilation rates in the European Standard opens for a corresponding lowering in the legislation of the member states. While it is slightly encouraging that the Swedish legislation is unchanged at the moment, as seen in \nTable 1\n, it is obvious that the risk of EPBD creating unhealthy indoor environments will be augmented. The present levels of indoor air quality in the building stock risk being lowered by the combined effect of tighter building envelopes and the prospect of lower required ventilation rates.
\n
\n
\n
\n
\n
\n
\n\n
\n
Category
\n
CEN EN 15251:2006
\n
CEN EN 16278.1:2019
\n
\n
\n
\n
Expected Percent Dissatisfied [%]
\n
Airflow per person [L⋅s−1/person]
\n
Expected Percent Dissatisfied
\n
Airflow per person L⋅s−1/person
\n
\n\n\n
\n
I
\n
10
\n
10
\n
10
\n
10
\n
\n
\n
II
\n
\n20\n
\n
\n7\n
\n
20
\n
7
\n
\n
\n
III
\n
30
\n
\n
\n30\n
\n
\n4\n
\n
\n
\n
IV
\n
< 30
\n
< 4
\n
40
\n
2.5
\n
\n
\n
\n
\nExpected Percent Dissatisfied [%]\n
\n
\nVery low polluting building [L⋅s−1/m2]\n
\n
\nExpected Percent Dissatisfied\n
\n
\nVery low polluting building [L⋅s−1/m2]\n
\n
\n
\n
I
\n
10
\n
0.5
\n
10
\n
0.5
\n
\n
\n
II
\n
\n20\n
\n
\n0.35\n
\n
20
\n
0.35
\n
\n
\n
III
\n
30
\n
\n
\n30\n
\n
\n0.2\n
\n
\n
\n
IV
\n
< 30
\n
<0.2
\n
40
\n
0.15
\n
\n\n
Table 2.
Values are extracted from the official European guidelines for ventilation requirements and air quality. CEN EN 15251:2006 are the old guidelines from 2006 [61] and CEN EN 16278.1:2019 are the new guidelines (valid from 8 May, 2019) [62] issued by European Committee for Standardization. The bold figures are the recommended values.
\n
As concluded in the previous section, simply specifying required ventilation rates cannot guarantee an adequately low exposure to indoor pollutants. [63] Legislation also need to address the air distribution. In the European Standard [62] and in the ASHRAE Standard [56], the given ventilation rates assume complete mixing in the room. Thus, they presuppose a mixing mechanical ventilation system. Other ventilation systems are accommodated by dividing with a correction factor. ASHRAE [26] proposes a correction factor called the air change effectiveness defined as \n\n\nε\nI\n\n=\n\nτ\nn\n\n/\n\n\nτ\n¯\n\n\n\n evaluated in the breathing zone. [56] For mixing ventilation this gives \n\n\nε\n\nI\n,\nmixed\n\n\n=\n1\n\n and for plug flow \n\n\nε\n\nI\n,\nplugflow\n\n\n=\n2\n\n. The correction factor in the European Standard is similarly defined, but evaluated as a room average, and is called ventilation effectiveness εv\n. (The nomenclature for the correction factors is a bit confusing and may be easily mixed-up with the air change efficiency defined in Eq. (12).) If the system is not fully mixed, the correction factor is less than unity and the required ventilation rate should be correspondingly increased. If displacement or plug flow ventilation systems are used, that are more efficient than mixing ventilation, the correction factor is larger than unity and the required ventilation rates may be correspondingly decreased.
\n
Legal ventilation requirements also address air distribution, but rephrased into requirements that newly installed ventilation should be shown to function as designed, that the ventilation rate should be sufficient, or by requiring a specified air change efficiency as in \nTable 1\n. I have the impression that air change efficiency is seldom tested in the field. The control of newly installed ventilation systems mostly consist of ensuring that the design ventilation flows are obtained, otherwise the ventilation system components are assumed to function with the same efficiency as in laboratory tests. However, there are a number of factors that may lower the ventilation system efficiency in a real building. Some of these factors were mentioned in connection with ventilation short-circuiting in previous section (see also \nFigure 5\n); ventilation systems may be very complex and design choices may have unforeseeable consequences; a ventilation designer may enter late in the planning process and may be forced to make suboptimal choices, e.g. inlets vents may end up too close to outlet vents; or occupants may tamper with the intended function of the ventilation components to minimize perceived draft. It may be prudent to verify that air is distributed with the intended efficiency in new and old ventilation installations.
\n
The above standards clearly favor mechanical ventilation systems where ventilation rate is an easy parameter to measure. It is not that easy to measure ventilation rate for natural ventilation systems. It is more difficult to demonstrate that natural ventilation systems are in compliance with the legal requirements than it is for mechanical ventilation systems. In addition, rooms with natural ventilation systems typically have higher room heights, than rooms with mechanical ventilation systems. Naturally ventilated rooms require larger room volumes to prevent concentration build-up of transient pollution sources to offset the natural fluctuations in the ventilation rate. Historically, the introduction of mechanical ventilation systems allowed building entrepreneurs to squeeze in three floors in the same volume where previously there would be two floors in older naturally ventilated buildings. [30] Using this observation, rooms with natural ventilation are roughly estimated to be 50% larger than rooms with mechanical ventilation. If there is a legally required air change rate or a required ventilation rate per floor area (as exemplified in \nTable 1\n), the prescribed ventilation rates will also be 50% larger for naturally ventilated rooms, as compared to a mechanically ventilated room. This increase is probably unnecessary and it arises because the legal requirements does not consider the different ventilation strategies used in natural ventilation systems. It would be desirable that all ventilation strategies should be treated equally in the eyes of the law, with the same objective requirements for adequate indoor air quality.
\n
If the objective of the legal regulations is to ensure that 80% of the occupants find the perceived air quality to be acceptable, as it appears to be, then it would be more fitting to simply require that less than 20% of the occupants are feeling uncomfortable. This could be tested in a questionnaire. Note that this approach is suggested in some environmental certification systems for buildings, e.g. the level GULD in Miljöbyggnad 3.1. [64] The problem with such an approach is that other factors, than the actual air quality, may affect the outcome. [27] Alternatively, the regulations should apply specifically to the occupied zone of a room. This would lead to more balanced demands on natural ventilation systems as compared to the demands on mechanical ventilation systems. To specify concentration limits in the occupied zone would be preferable because of the direct link to exposure, but the challenge is that the human nose is very sensitive so some substances and there may be difficulties to measure such low concentrations at the present time. An indirect approach would be to specify some local ventilation parameter, such as the local mean age of air, in the occupied zone.
\n
The fact that ventilation requirements primarily targets occupant comfort, does not mean that ventilation is irrelevant for the health of the occupants. Adverse health effects caused by exposure to indoor air pollution have been estimated to cause that approximately two million disability-adjusted lifetime years (DALYs) are lost annually, based on the population in 26 European countries. In economic terms this corresponds to a societal cost exceeding €200 billion. [60] It is very likely that the combined effect of the lower ventilation requirements and tighter building envelopes due to EPBD will increase this societal cost considerably. The prospect of turning buildings into unhealthy containers for the occupants certainly tempers my enthusiasm for the projected EPBD energy savings.
\n
\n
\n
\n
3. Conclusions
\n
Most legislations concerning ventilation are based on perceived air quality, but ventilation is also important for the health of the occupants. Perceived air quality can be viewed as a pragmatic tool to achieve an adequate ventilation for precautionary health measures. From a perceived air quality and health perspective, the ventilation rate and an efficient air distribution are both important for achieving a healthy and comfortable indoor environment. Yet, most legislative requirements focus on the ventilation rate. This is not enough, and it is recommended that legislation also address the air distribution with equal zeal. In particular, verifying the efficient distribution of fresh air to the occupied zones or the concentrations of pollutants in the occupied zones.
\n
Because there are clear links between ventilation and health, [3, 4, 50, 51, 60], it is extremely worrying that the “energy efficiency first” principle advocated in EPBD has led to decreasing ventilation requirements in the EU legislations, at the same time as the objective is to aggressively tighten the envelopes of the building stock. A second consequence of EPBD is probably that many naturally ventilated buildings will be retrofitted with mechanical ventilation systems. It is not clear that this would be the more sustainable solution in the long run.
\n
Every citizen’s right to a healthy indoor environment has been suggested to be a basic Human Right by WHO. [65] Adequate ventilation is at the heart of the solutions to reach this commendable goal. The mantra “build tight – ventilate right” [66] is a good one, but do not forget the second part!
\n
\n
Acknowledgments
\n
The author wishes to acknowledge helpful discussions with Jan Sundell. He will be missed.
\n
Conflict of interest
The author also works as a ventilation consultant.
\n',keywords:"ventilation requirements, ventilation rates, air distribution, air change rate, local mean age of air, air change efficiency, indoor air quality, EPBD, natural ventilation",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76623.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76623.xml",downloadPdfUrl:"/chapter/pdf-download/76623",previewPdfUrl:"/chapter/pdf-preview/76623",totalDownloads:137,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 1st 2020",dateReviewed:"April 14th 2021",datePrePublished:"May 6th 2021",datePublished:null,dateFinished:"May 6th 2021",readingETA:"0",abstract:"Most legislations concerning ventilation are based on perceived air quality criteria, but ventilation is also important for the health of the occupants. The perceived air quality criteria can be viewed as a pragmatic tool to achieve an adequate ventilation for precautionary health measures. From a comfort and health perspective, the ventilation rate and an efficient air distribution are both important for achieving a healthy and comfortable indoor environment. Yet, most legislative requirements focus on the ventilation rate. This is not enough, and it is recommended that legislation also address the air distribution with the same zeal. In particular, the efficient distribution of fresh air to the occupied zones or lowering the concentrations of pollutants in the occupied zones. Because there are clear links between ventilation and health, it is extremely worrying that the “energy efficiency first” principle advocated in the Energy Performance of Buildings Directive (EPBD) has led to decreasing ventilation requirements in the European Union legislations, at the same time as the objective is to aggressively tighten the envelopes of the building stock. A second consequence of EPBD is probably that many naturally ventilated buildings will be retrofitted with mechanical ventilation systems. It is not clear that this would be the more sustainable solution in the long run.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76623",risUrl:"/chapter/ris/76623",signatures:"Mikael Björling",book:{id:"10811",type:"book",title:"Urban Transition - Perspectives on Urban Systems and Environments",subtitle:null,fullTitle:"Urban Transition - Perspectives on Urban Systems and Environments",slug:null,publishedDate:null,bookSignature:"Ph.D. Marita Wallhagen and Dr. Mathias Cehlin",coverURL:"https://cdn.intechopen.com/books/images_new/10811.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83962-413-1",printIsbn:"978-1-83962-412-4",pdfIsbn:"978-1-83962-414-8",isAvailableForWebshopOrdering:!0,editors:[{id:"337569",title:"Ph.D.",name:"Marita",middleName:null,surname:"Wallhagen",slug:"marita-wallhagen",fullName:"Marita Wallhagen"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Requirements for ventilation",level:"1"},{id:"sec_2_2",title:"2.1 A short history of ventilation and health effects",level:"2"},{id:"sec_3_2",title:"2.2 Some insights from the theory of ventilation",level:"2"},{id:"sec_4_2",title:"2.3 A critical examination of guidelines for ventilation requirements",level:"2"},{id:"sec_6",title:"3. Conclusions",level:"1"},{id:"sec_7",title:"Acknowledgments",level:"1"},{id:"sec_10",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'\nEuropean Union. The Directive 2010/31/EU of the European Parliament and of the Council of 19 May 2010 on the energy performance of buildings. Official Journal of the European Union, 53. Brussels, Belgium: European Union; 2010. Available at: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:153:0013:0035:EN:PDF. [Accessed: 2021-02-05]\n'},{id:"B2",body:'\nAllen J. The Nexus of Buildings, Global Health, and the U.N. 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DOI: 10.1016/0160-4120(86)90022-X\n'},{id:"B53",body:'\nFarmer DK, Vance ME, Abbatt JPD, Abeleira A, Alves MR, Arata C, Boedicker E, Bourne S, Cardoso-Saldana F, Corsi R, DeCarlo PF, Goldstein AH, Grassian VH, Hildebrandt Ruiz L, Jimenez JL, Kahan TF, Katz EF, Mattila JM, Nazaroff WW, Novoselac A, O’Brien RE, Or VW, Patel S, Sankhyan S, Stevens PS, Tian Y, Wade M, Wang C, Zhou S, Zhou Y. Overview of HOMEChem: House Observations of Microbial and Environmental Chemistry. Environ. Sci.: Processes Impacts, 2019;21:1280–1300. DOI: 10.1039/C9EM00228F\n\n'},{id:"B54",body:'\nEC (European Commission). Toxicity and assessment of chemical mixtures. Brussels: European Commission. Directorate-General for Health & Consumers – Scientific Committee on Health and Environmental Risks (SCHER), Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR), Scientific Committee on Consumer Safety (SCCS), final approved opinion; 2011. Available from: http://ec.europa.eu/health/scientific_committees/environmental_risks/docs/scher_o_155.pdf [Accessed: 2021-02-05]\n'},{id:"B55",body:'\nEtheridge DW, Sandberg M. Building ventilation: theory and measurement. Chichester: Wiley; 1996\n'},{id:"B56",body:'\nVentilation for Acceptable Indoor Air Quality; ASHRAE Standard 62.1. Atlanta, GA, USA: American Society of Heating, Refrigerating, and Air-Conditioning Engineers; 2017\n'},{id:"B57",body:'\nWorkplace design: Provisions of the Swedish Work Environment Authority on workplace design and general recommendations on the implementation of the provisions (AFS 2009:2) [Internet]. Stockholm: The Swedish Work Environment Authority. Available from: https://www.av.se/globalassets/filer/publikationer/foreskrifter/engelska/workplace-design-provisions-afs2009-2.pdf [Accessed: 2021-02-05]\n'},{id:"B58",body:'\nArbetsplatsens utformning (AFS 2021:1) [Internet]. Stockholm: The Swedish Work Environment Authority. Available from: https://www.av.se/globalassets/filer/publikationer/foreskrifter/arbetsplatsens-utformning-afs2020-1.pdf [Accessed: 2021-02-05]\n'},{id:"B59",body:'\nFolkhälsomyndighetens allmänna råd om ventilation (FoHMFS 2014:18) [Internet]. Stockholm: The Public Health Agency of Sweden. Available from: https://www.folkhalsomyndigheten.se/contentassets/641784832543443ea4eebe9b300c244e/fohmfs-2014-18.pdf [Accessed: 2021-02-05]\n'},{id:"B60",body:'\nCarrer P, de Oliveira FE, Santos H, Hänninen O, Kephalopoulos S, Wargocki P. On the Development of Health-Based Ventilation Guidelines: Principles and Framework. Int. J. Environ. Res. Public Health. 2018;15:1360. DOI: 10.3390/ijerph15071360\n'},{id:"B61",body:'\nIndoor environmental input parameters for design and assessment of energy performance of buildings addressing indoor air quality, thermal environment, lighting and acoustics; EN 15251. Brussels, Belgium: European Committee for Standardization; 2007\n'},{id:"B62",body:'\nEnergy performance of buildings – Ventilation for buildings –Part 1: Indoor environmental input parameters for design and assessment of energy performance of buildings addressing indoor air quality, thermal environment, lighting and acoustics –Module M1-6; EN 16798.1. Brussels, Belgium: European Committee for Standardization; 2019\n'},{id:"B63",body:'\nFanger PO. New principles for a future ventilation standard. In: Proceedings of the Fifth International Conference on Indoor Air Quality and Climate; 29 July-3 August 1990; Toronto. Canada: ISIAQ; 1990. p. 353–363\n'},{id:"B64",body:'\nSweden Green Building Council. Miljöbyggnad 3.1. Available from: https://www.sgbc.se/app/uploads/2020/05/Milj%C3%B6byggnad-3.1-Nybyggnad.pdf [Accessed: 2021-02-05]\n'},{id:"B65",body:'\nWorld Health Organization. The Right to Healthy Indoor Air. In: Proceedings of the WHO Meeting, Bilthoven, The Netherlands, 15–17 May 2000; Copenhagen, Denmark: WHO Regional Office for Europe; 2000\n'},{id:"B66",body:'\nPerera E, Parkins L. Build tight – ventilate right. London: Building Services, Chartered Institution of Building Services Engineers;1992\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Mikael Björling",address:"mikael.bjorling@hig.se",affiliation:'
Department of Electrical Engineering, Mathematics and Science, Faculty of Engineering and Sustainable Development, University of Gävle, Gävle, Sweden
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We believe financial barriers should not prevent researchers from publishing their findings. With the need to make scientific research more publicly available and support the benefits of Open Access, more and more institutions and funders are dedicating resources to assist faculty members and researchers cover Open Access Publishing Fees (OAPFs). In addition, IntechOpen provides several further options presented below, all of which are available to researchers, and could secure the financing of your Open Access publication.
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Paying the OAPF
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The first step in obtaining funds for your Open Access publication begins with your institution or library. IntechOpen’s publishing standards align with most institutional funding programs. Our advice is to petition your institution for help in financing your Open Access publication.
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Please consult our Open Access Funding page to explore some of these funding opportunities and learn more about how you could finance your IntechOpen publication. Keep in mind that this list is not definitive, and while we are constantly updating and informing our Authors of new funding opportunities, we recommend that you always check with your institution first.
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IntechOpen Waivers in Action
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For Authors who are unable to obtain funding from their institution or research funding bodies and still need help in covering publication costs, IntechOpen offers the possibility of applying for a Waiver.
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While providing support and advice to all our international Authors, waiver priority will be given to those Authors who reside in countries that are classified by the World Bank as low-income economies. In this way, we can help ensure that the scientific work being carried out can make an impact within the worldwide scientific community, no matter where an Author might live.
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How to Apply for a Waiver
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Note: All data represented above was collected by IntechOpen from 2013 to 2017.
At IntechOpen, the majority of OAPFs are paid by an Author’s institution or funding agency - Institutions (73%) vs. Authors (23%).
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The first step in obtaining funds for your Open Access publication begins with your institution or library. IntechOpen’s publishing standards align with most institutional funding programs. Our advice is to petition your institution for help in financing your Open Access publication.
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Please consult our Open Access Funding page to explore some of these funding opportunities and learn more about how you could finance your IntechOpen publication. Keep in mind that this list is not definitive, and while we are constantly updating and informing our Authors of new funding opportunities, we recommend that you always check with your institution first.
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IntechOpen Waivers in Action
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For Authors who are unable to obtain funding from their institution or research funding bodies and still need help in covering publication costs, IntechOpen offers the possibility of applying for a Waiver.
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Our mission is to support Authors in publishing their research and making an impact within the scientific community. Currently, 14% of Authors receive full waivers and 6% receive partial waivers.
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While providing support and advice to all our international Authors, waiver priority will be given to those Authors who reside in countries that are classified by the World Bank as low-income economies. In this way, we can help ensure that the scientific work being carried out can make an impact within the worldwide scientific community, no matter where an Author might live.
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How to Apply for a Waiver
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The application process is open after your submitted manuscript has been accepted for publication. To apply, please fill out a Waiver Request Form and send it to your Author Service Manager. If you have an official letter from your university or institution showing that funds for your OA publication are unavailable, please attach that as well. The Waiver Request will normally be addressed within one week from the application date. All chapters that receive waivers or partial waivers will be designated as such online.
Feel free to contact us at funders@intechopen.com if you have any questions about Funding options or our Waiver program. If you have already begun the process and require further assistance, please contact your Author Service Manager, who is there to assist you!
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Note: All data represented above was collected by IntechOpen from 2013 to 2017.
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These geological elements have been evaluated to understand possible cause(s) of rapid decline in pro¬duction. The N5.2 reservoir, located in shallow marine sandstones, offshore Niger Delta, has experienced decline in oil rate with a corresponding increase in water-cut within two years of beginning of production. The main objective of this study is the determination of reservoir architecture in order to individuate the possible cause(s) of rapid production decline. To this aim, several methods have been used, including the seismic attribute analysis, electrofacies analysis, well log and petrophysical correlations. The obtained results show that the N5.2 reservoir is a massive sandy unit, occurring within the paralic Agbada Formation of about 2133 m thick. A contour depth map of the reservoir shows the occurrence of a structural saddle associated with an elongated closure having two structural culminations. Further analysis using the root mean square (RMS) and anti-tracking seismic attributes has indicated a seismic facies parallel to the paleo-coastline direction and several faults and fractures. The high quality of the reservoir, fractures, poor management and water injection may have induced rapid fluid flow and consequently early watercut and decline in production.",book:{id:"7768",slug:"sedimentary-processes-examples-from-asia-turkey-and-nigeria",title:"Sedimentary Processes",fullTitle:"Sedimentary Processes - Examples from Asia, Turkey and Nigeria"},signatures:"Prince Suka Momta",authors:[{id:"228567",title:"Dr.",name:"Prince Suka",middleName:null,surname:"Momta",slug:"prince-suka-momta",fullName:"Prince Suka Momta"}]},{id:"54964",title:"Intermittent Formation, Sedimentation and Deformation History of Cenozoic Forearc Basins along the Northwestern Pacific Margins as an Indicator of Tectonic Scenarios",slug:"intermittent-formation-sedimentation-and-deformation-history-of-cenozoic-forearc-basins-along-the-no",totalDownloads:3058,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"This chapter examines the basin-filling stratigraphy and major unconformity events of the Cenozoic forearc basins in the NE Japan, SW Japan, Ryukyu and Izu-Bonin forearc territories along the northwestern Pacific margins to obtain information on the background tectonic scenarios along the plate subduction zones. The forearc basin type and tectonic history are characteristic for each forearc territory, reflecting the differences in plate tectonic processes. Several major unconformity events seem to be synchronous for a forearc territory or whole forearc territories around Japan, suggesting that these events originated from more or less wider scale plate tectonic events. In the NE Japan forearc territory, the Oligocene unconformity can be the largest events, which transformed the forearc basin styles from the trench slope break-uplifted, fluvial system-dominated type to the tensional, deeper marine sloped type. In the SW Japan and Ryukyu forearc territories, the latest Oligocene to Middle Miocene gap was the transformation phase from the Palaeogene Shimanto-type forearc and accretionary complex, to the Neogene compressive, sloped to ridged forearc basins, developments of which have been interrupted by several unconformity events possibly related to changes in plate tectonic condition. 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\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"May 19th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. His research interests include biochemistry, oxidative stress, reactive species, antioxidants, lipid peroxidation, inflammation, reproductive hormones, phenolic compounds, female infertility.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"18",type:"subseries",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",slug:"cesar-lopez-camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{paginationCount:3,paginationItems:[{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. 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Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. 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Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. 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