\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5759",leadTitle:null,fullTitle:"Lamination - Theory and Application",title:"Lamination",subtitle:"Theory and Application",reviewType:"peer-reviewed",abstract:"The field of lamination has developed significantly over the past 5000 years. Nowadays, we have a humongous array of structures and technological systems where composite laminates are applied. From the viewpoint of structural mechanics, an interface slip motion between two laminated structures, such as beam plate and plate in the presence of dry friction, can be utilized for slip damping systems. By scientific definition, slip damping is a mechanism exploited for dissipating noise and vibration energy in machine structures and systems. Researchers have developed several mathematical models for noise dissipation, minimization and complete vibration isolation laminated mechanisms. The purpose of this book is to describe new concepts of producing laminated structures and possible modern engineering applications.",isbn:"978-953-51-3926-3",printIsbn:"978-953-51-3925-6",pdfIsbn:"978-953-51-3973-7",doi:"10.5772/65194",price:119,priceEur:129,priceUsd:155,slug:"lamination-theory-and-application",numberOfPages:124,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"9a4f81291f9d75ed83b1f4f5e0b56f36",bookSignature:"Charles A. Osheku",publishedDate:"March 21st 2018",coverURL:"https://cdn.intechopen.com/books/images_new/5759.jpg",numberOfDownloads:7e3,numberOfWosCitations:9,numberOfCrossrefCitations:11,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:15,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:35,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 10th 2017",dateEndSecondStepPublish:"January 31st 2017",dateEndThirdStepPublish:"August 5th 2017",dateEndFourthStepPublish:"September 5th 2017",dateEndFifthStepPublish:"November 5th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"148660",title:"Dr.",name:"Charles",middleName:"Attah",surname:"Osheku",slug:"charles-osheku",fullName:"Charles Osheku",profilePictureURL:"https://mts.intechopen.com/storage/users/148660/images/6109_n.png",biography:"Dr. Charles Attah Osheku was the Director of the Centre for Space Transport and Propulsion, Epe, Lagos, an activity Centre of the National Space Research and Development Agency (NASRDA), Nigeria. He obtained BSc in Mechanical Engineering from the Obafemi Awolowo University; MSc and PhD in Mechanical Engineering (Engineering Mechanics) from the University of Lagos, Nigeria. He was the incumbent Chairman of the Lagos Branch of Nigeria Society of Engineers\\\\\\' (NSE) Space Engineering Division and a Board Member of the Division. Dr Osheku was a Research Expert in Rockets and Missiles Solid Fuel Physics, Solid Rocket Engines Design, Structural, Flow and Combustion-induced Vibrations, Aircraft and Jet Noise Modelling and Dissipation and Vibration of Laminated Structures. Dr Osheku has 63 scientific papers to his credit, published in reputable International Journals, ASME International Offshore Mechanics Conferences. He is a COREN (Nigeria) - registered Engineer and a professional member of ASME and AIAA.\r\n\r\nNote from the publisher:\r\n\r\nIt is with great sadness and regret that we inform the contributing authors and future readers of this book that the Editor, Dr. Charles Attah Osheku passed away during the publishing process of the book and before having a chance to see its publication. Dr. Osheku was IntechOpen\\'s long term collaborator and edited his first book with us in 2018 (\\'\\'Lamination\\'\\'). The book \\'\\'Ballistics\\'\\' was his secont edited volume and contains his third published chapter with us. The fruitful collaboration continued until his final days. We would like to acknowledge Dr. Osheku\\'s contribution to scientific publishing, which he made during years of dedicated work and express our gratitude for his pleasant cooperation with us.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1370",title:"Manufacturing Engineering",slug:"technology-material-science-manufacturing-engineering"}],chapters:[{id:"59643",title:"Introductory Chapter: Laminations - Theory and Applications",doi:"10.5772/intechopen.74457",slug:"introductory-chapter-laminations-theory-and-applications",totalDownloads:1247,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Charles Attah Osheku",downloadPdfUrl:"/chapter/pdf-download/59643",previewPdfUrl:"/chapter/pdf-preview/59643",authors:[{id:"148660",title:"Dr.",name:"Charles",surname:"Osheku",slug:"charles-osheku",fullName:"Charles Osheku"}],corrections:null},{id:"56537",title:"Multiscale Hierarchical Structure and Laminated Strengthening and Toughening Mechanisms",doi:"10.5772/intechopen.69976",slug:"multiscale-hierarchical-structure-and-laminated-strengthening-and-toughening-mechanisms",totalDownloads:1463,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Metal matrix composites with multiscale hierarchical structure and laminated structure have been developed to provide a novel route to achieve high strength, toughness and ductility. In this chapter, a lot of scientific research has been carried out in the preparation, processing, properties and application of metal matrix composite. Many toughening mechanisms and fracture behavior of composites with multiscale hierarchical structure and laminated structure are overviewed. It is revealed that elastic property and yield strength of laminated composites follow the “rule of average.” However, the estimation of fracture elongation and fracture toughness is complex, which is inconsistent with the “rule of average.” The fracture elongation of laminated composites is related to the layer thickness size, interface, gradient structure, strain hardening exponent, strain rate parameter and tunnel crack, which are accompanied with crack deflection, crack blunting, crack bridging, stress redistribution, local stress deformation, interfacial delamination crack and so on. The concept of laminated composites can be extended by applying different combination of individual layer, and provides theoretical as well as experimental fundamentals on strengthening and toughening of metal matrix composites.",signatures:"Baoxi Liu, Lujun Huang, Lin Geng and Fuxing Yin",downloadPdfUrl:"/chapter/pdf-download/56537",previewPdfUrl:"/chapter/pdf-preview/56537",authors:[{id:"140305",title:"Dr.",name:"Lin",surname:"Geng",slug:"lin-geng",fullName:"Lin Geng"},{id:"197727",title:"Dr.",name:"Baoxi",surname:"Liu",slug:"baoxi-liu",fullName:"Baoxi Liu"},{id:"197732",title:"Prof.",name:"Lujun",surname:"Huang",slug:"lujun-huang",fullName:"Lujun Huang"},{id:"207654",title:"Prof.",name:"Fuxing",surname:"Yin",slug:"fuxing-yin",fullName:"Fuxing Yin"}],corrections:null},{id:"56424",title:"Bending of Laminated Composite Plates in Layerwise Theory",doi:"10.5772/intechopen.69975",slug:"bending-of-laminated-composite-plates-in-layerwise-theory",totalDownloads:1367,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Determination of stress‐strain state in contemporary laminated composite plates containing layers with continuous unidirectional fibers requires the application of refined plate theories, which include layerwise theory. In contrast to homogeneous isotropic plates, heterogeneity of the anisotropic structure of laminated composite plates often leads to the appearance of imperfections in the connection between the layers. Mathematical models, which are formed on the assumption that the plate is homogeneous and isotropic, cannot properly include irregularities that can occur at the level of the layer in the process of manufacture, transportation, installation, or exploitation. Mathematical models of layerwise theory allow defining a more realistic stress‐strain state through the thickness of the plate, where consideration is carried out at the level of the layer. Additionally, this model makes possible to include delaminations that might occur on the connection between the individual layers. In this chapter, Reddy's layerwise theory is applied in order to determine equations for the problem of bending of laminated composite plates. The bending equations are solved by applying analytical method by means of double trigonometric series, as well as by using numerical methods based on the finite elements. This chapter presents examples for both applied approaches.",signatures:"Marina Rakočević",downloadPdfUrl:"/chapter/pdf-download/56424",previewPdfUrl:"/chapter/pdf-preview/56424",authors:[{id:"205043",title:"Prof.",name:"Marina",surname:"Rakocevic",slug:"marina-rakocevic",fullName:"Marina Rakocevic"}],corrections:null},{id:"58142",title:"Dynamic Modeling of a Serial Link Robot Laminated with Plastic Film",doi:"10.5772/intechopen.72441",slug:"dynamic-modeling-of-a-serial-link-robot-laminated-with-plastic-film",totalDownloads:1134,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter presents serial link robots laminated with a plastic film, a derivation of the equations of motion of the laminated robots, and numerical simulation. Recently, to become capable of wide application for several serial link robots that work outside, waterproofing and dustproofing techniques are required. We have proposed a robot packaging method to improve waterproof and dustproof properties of serial link robots. Using the proposed packaging method, rigid links with some active joints are loosely laminated with plastic film to protect the links from dust and water. In the next step of our research, we must derive the equations of motion of the laminated robots for the design and performance improvement from the viewpoint of high speed and high energy efficiency. We assume a plastic film as a closed-loop link structure with passive joints in this chapter. A rigid serial link (fin) connected with a motor-actuated joint moves a closed-loop link structure with passive joints. We numerically investigate the influence of the flexural rigidity of a plastic film on the motion of the rigid fin. This research not only contributes to the lamination techniques but also develops a novel application of waterproofing and dustproofing techniques in robotics.",signatures:"Norimitsu Sakagami and Mizuho Shibata",downloadPdfUrl:"/chapter/pdf-download/58142",previewPdfUrl:"/chapter/pdf-preview/58142",authors:[{id:"180106",title:"Dr.",name:"Mizuho",surname:"Shibata",slug:"mizuho-shibata",fullName:"Mizuho Shibata"},{id:"219910",title:"Prof.",name:"Norimitsu",surname:"Sakagami",slug:"norimitsu-sakagami",fullName:"Norimitsu Sakagami"}],corrections:null},{id:"59742",title:"Advanced Technologies in Manufacturing 3D-Layered Structures for Defense and Aerospace",doi:"10.5772/intechopen.74331",slug:"advanced-technologies-in-manufacturing-3d-layered-structures-for-defense-and-aerospace",totalDownloads:1791,totalCrossrefCites:6,totalDimensionsCites:7,hasAltmetrics:0,abstract:"In the past 20 years, a great progress has been made in additive manufacturing techniques, which has led to numerous applications in aeronautical and defense structures. Though not all advanced materials and alloys, can be automatically layered by a rapid prototyping system or machine, several interesting application have seen the light of publicity in many sectors. Efforts are underway to apply the automated layering technologies in as many materials as possible, mostly nowadays plastics, reinforced-polymers, and metals can be processed by such systems in order to produce three-dimensional parts. The work is underway internationally in order to promote more and more applications of additive manufacturing or automated layering and to lower the costs in such systems. This paper aims at presenting a review of the additive manufacturing history presenting the major steps that lead to the explosion of this technology, and with a special focus on advanced 3D structures in aerospace and defense applications. An insight is also given on the four dimensions of manufacturing concept.",signatures:"Dionysios E. Mouzakis",downloadPdfUrl:"/chapter/pdf-download/59742",previewPdfUrl:"/chapter/pdf-preview/59742",authors:[{id:"107011",title:"Associate Prof.",name:"Dionysios",surname:"Mouzakis",slug:"dionysios-mouzakis",fullName:"Dionysios Mouzakis"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6595",title:"Ballistics",subtitle:null,isOpenForSubmission:!1,hash:"3e7fa96253ce890c092b37a8678e4d03",slug:"ballistics",bookSignature:"Charles Osheku",coverURL:"https://cdn.intechopen.com/books/images_new/6595.jpg",editedByType:"Edited by",editors:[{id:"148660",title:"Dr.",name:"Charles",surname:"Osheku",slug:"charles-osheku",fullName:"Charles Osheku"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3683",title:"Engineering the Future",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"engineering-the-future",bookSignature:"Laszlo Dudas",coverURL:"https://cdn.intechopen.com/books/images_new/3683.jpg",editedByType:"Edited by",editors:[{id:"135546",title:"Prof.",name:"Laszlo",surname:"Dudas",slug:"laszlo-dudas",fullName:"Laszlo Dudas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6306",title:"Additive Manufacturing of High-performance Metals and Alloys",subtitle:"Modeling and Optimization",isOpenForSubmission:!1,hash:"0e08cc35cef3caf389096ca4b999742f",slug:"additive-manufacturing-of-high-performance-metals-and-alloys-modeling-and-optimization",bookSignature:"Igor V. 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Amid the major transitions occurring under the “digital transformation” (DX) label, there has been a surge in motivation for “industry-government-academia partnerships,” in which universities form cooperative relationships in society to undertake various projects.
Industry-government-academia partnerships can make major contributions to revitalizing universities and developing society, and for some time there have been calls to improve and strengthen these endeavors. Universities play an important role as sources of knowledge for society as a whole, and because they are places for training highly specialized professionals, for local governments and companies they are a valuable resource for vitalizing and promoting communities, industries, and other sectors. One current trend is that companies are no longer seeing universities merely as a source of workers, but also as partners in producing creative seed technologies and as places to outsource research development (R&D) and personnel development. In response to this, university education is diversifying with the goal of fostering creative and practical professionals in ways that takes the needs of industry into account. Needs for lifelong learning, such as through recurrent education, have also increased in recent years, as part of efforts to adapt to trends including the “new normal,” changes in management to incorporate VUCA (volatility, uncertainty, complexity, and ambiguity), and the increasing sophistication of industrial technology.
University education needs to be sensitive to rapidly changing societal conditions and be able to adapt quickly. To achieve this, education must not only give students problem-solving skills but also help them develop the ability to first identify problems. Our university trains students in the fields of health, medical, and welfare, and can provide assistive technology to address aspects of community and industrial health from prevention to rehabilitation. The university is capable of exploring and intervening in issues related to frailty caused by measures to control the novel coronavirus. (In this context, frailty is the deterioration of mental and physical functions and the loss of social connections from restricting one’s behavior.) To put its powers to full use for the good of society, the university has concluded comprehensive agreements with local governments and industries and is engaged in health-related initiatives to help create vibrant and independent communities. Within the university, efforts are underway to discover and develop promising seeds that will produce support and creativity based on original concepts.
“Industry” refers to the corporate sector in a broad sense, which includes private companies and nonprofit organizations. Industrial R&D plays an important role in that it is tied directly to economic activity. Companies conduct various surveys to find out the needs of their target customers. Companies that manage large shopping centers have concluded that “health” is one of the main concerns of their customers. The same is true for life insurance companies, which are always thinking about how to provide health-related initiatives. In addition, the sale of sports-related products, shoes, and clothes is no exception to this. In this, we can find some points of connection with the seeds related to health promotion developed at our university. Specifically, we have made proposals on sports/training instruction, matching the fit of footwear to growth, continuous regular exercise, and walking in large shopping centers, and have worked with companies to implement these ideas.
“Government” refers to publicly funded, government-affiliated research institutes such as R&D-type incorporated administrative agencies, as well as national and municipal organizations. Public research institutes carry out strategic research with specific goals to improve scientific and medical technology, in ways that follow basic research, cutting-edge research, and societal needs. For example, the university has collaborated with the National Center for Geriatrics and Gerontology at the Japan Science and Technology Agency, to develop effective exercise regimens for elderly people who have been forced to restrict their lifestyles due to the coronavirus pandemic, and has helped produce videos for public education. We are already looking to the post-pandemic world and exploring initiatives for the new normal. National and local governmental organizations play an important role in improving systems. The main objectives of and important challenges for public community comprehensive aid centers that support the long-term care insurance system are “preventing the need for long-term care” and “promoting health.” Through an industry-government-academia partnership, the university is planning a sustainable and effective initiative aimed at elderly people at a major shopping center. Municipal bulletins, which have a high level of public trust, will be used to promote participation. As an example of the strategic partnership, a fun setting where different age groups, including students, can interact will be used to collect data on factors such as physical function, activity levels, and psychological/behavioral changes. This will then be objectively analyzed and assessed to provide participants with feedback. It is also important to use these processes and results in educational areas.
“Academia” is the academic sector that includes universities, inter-university research institutes, and higher technical colleges. The basic mission of these institutions is to provide education and conduct academic research, but also to contribute to society. Their role is to train and secure top-level professionals who can create new knowledge and carry forward intellectual assets into the future. The university offers off-campus practical training for nurses, physical therapists, occupational therapists, social workers, and long-term care workers to deepen students’ understanding of society. Having students learn in hospitals, care facilities, and companies will help them to reflect on and organize their own work, create new perspectives, and provide opportunities to verify outcomes. Universities contribute to their communities through a cycle of research followed by applying that knowledge to education. Constantly thinking about social significance, considering the strengths and weaknesses of one’s knowledge and wisdom, and learning in society create the ability to uncover problems, then solve them.
Industry-government-academia partnerships occur across sectors with fundamentally different missions and roles. When they are formed, it is important for the parties to understand and respect each other’s missions and roles, and to use the vitality of each to complement one another. The “cooperation agreements” that are often used in these endeavors are characterized by carrying out things through mutual contact and discussion, but not by creating continuous and stable relationships with strong bonds.
Research activities such as joint and sponsored research projects.
Practical education partnerships such as internships and practical training.
Collaborative development of educational programs in clinical and real-world settings.
Technology transfers related to research outcomes.
Consulting activities such as technical guidance and support.
Partnerships can be put into the above five categories. However, in actual industry-government-academia partnerships, these activities are closely related and it is rare for a single category to exist independently. Industry-government-academia partnerships are often constructed to involve several elements simultaneously. For example, a partnership related to low-back pain consultations among production engineering workers may include both exercises and treatments for low-back pain (technology transfers) as well as offering consultations in the work environment. In a broad sense, industry-government-academia partnerships can also include things that occur in the lead up to full-scale collaboration, such as dissemination of educational or research data, inter-sector exchanges between stakeholders, holding open lectures such as by sending corporate representatives to speak at universities, and offering space inside a company’s industry-academia exchange facility. Considering the diversity of activities associated with industry-government-academia partnerships, research is needed into how they should be implemented and the best policies for them.
To comprehensively promote new academic research, generate technological innovations, and solve social issues through these partnerships, it is important that in addition to medicine and the natural sciences, which have often been the subject of these endeavors, to also promote partnerships in the humanities and social sciences that primarily focus on relationships between people.
There is a growing awareness that as people approach 100 years of life, illness is not something that can be completely cured but is rather something they need to have a relationship with. In other words, modern rehabilitation needs the ability to adapt, to figure out how to come to terms with illness. This ability is affected not only by medical care, but also by the societies in which these people live, their surrounding environments, and their level of psychological satisfaction. Further, keeping in mind the specialization of the companies that play leading roles in industry, government, and academia; the characteristics and types of universities; and that fields of research will be at differing levels of progress, there is also a need to think about how to support progress in diversity and inclusion, or the acceptance of a wide variety of views and people. Each institution needs to make independent and strategic assessments of which activities to focus on based on their individuality and characteristics.
Universities have a certain responsibility to society as a whole to promote academic research and train highly skilled professionals. Therefore, it is important to respect the independence of universities, though they must also adopt an approach of autonomously responding to the time’s expectations of society.
Historically, education and research have been the missions of universities, but as social conditions change, so are the roles universities are expected to take on. In addition to education and research, universities are now expected to make social contributions, which is becoming a “third mission.” Human resource development and academic research make long-term contributions to the development of society, though in recent years shorter-term and more direct contributions have been sought through things like public lectures, commercialization of research results, and technology transfers. These endeavors are often referred to as the “social contribution of the third mission.” However, “social contribution” does not mean mere economic revitalization, but contributions made to the development of societies (including local communities, economic societies, and the international community) overall, in terms of local communities and welfare/environmental issues. Our university is engaged in concrete initiatives in the community under the keyword “health.” Social contribution by universities, which are institutions for educating students, should not be merely the offering of unpaid labor or the free use of facilities but should utilize their unique characteristics as bases of knowledge [3]. The goal should be to use the knowledge gained through educational and research activities to benefit local communities through joint research projects and technology transfers as part of industry-government-academia partnerships, which can improve the lives and welfare of local residents and help create a vital and prosperous society. Currently, there is growing public interest in technology transfers and the creation of new industries through industry-government-academia partnerships. These are ways universities can make social contributions, and each school should adopt approaches that are suited to its individuality and characteristics in ways that incorporate the diversity of society.
Diversity needs to be engaged with not only by each university but also at the individual faculty level. However, considering the diversity and originality of the research themes faculty are engaged in, if they are approached by industry about their own research results or themes, they should search for ways to use these results while receiving organizational support, such as by contacting the university department in charge of industry-government-academia collaboration. Therefore, regardless of the academic field, each faculty member needs to be constantly aware that the university is expected to make social contributions.
Industry-government-academia collaboration can also make great contributions to revitalizing university education. Therefore, along with providing opportunities for students to interact with companies through joint research, practical training, and internships, the industry can offer perspectives and cooperation in the realm of university education, such as by developing joint educational programs and hiring people with corporate experience. This can also be effective from the perspective of promoting practical education and training professionals who can meet the needs of industry and the rest of society. It goes without saying that the knowledge and experience faculty members gain through industry-government-academia partnerships will ultimately come back to benefit students through educational activities.
On the research side, in addition to conventional academic research, there is a growing awareness of the significance of research that focuses on and solves social issues. Thanks to rapid progress in DX and ICT, more joint research projects involving various organizations and institutions are expected. Society’s expectations and demands for industry-government-academia partnerships that make use of university research results are growing [4].
Technological innovation and the creation of new industries using the resources and potentials from R&D in the community are an important part of promoting community science and technology and of revitalizing Japan’s economy. Organic collaboration among regional institutions is needed, such as through the creation of knowledge clusters. It is relatively easy to encourage people to participate because the goal is not to generate profits but to reach out to the local community with the assistance of local governments. Once knowledge is obtained, it must be widely disseminated via feedback and public relations. Doing this over and over will help win the trust of society and lead to more inquiries from companies. No single intervention or approach is best. Each initiative must bear in mind the characteristics of the community and the conditions of local industries.
The authors declare that they have no competing interests.
Traditional societies have long considered what it means to be male or female, masculine and feminine. Ancestors have watched the sun and the moon for clues and signs as to natures of man and woman, masculine and feminine [1]. The creation stories around the world have always included roles of masculine and feminine in forming the world as we know it and its organizing principles [2, 3, 4]. Moreover, many places around the world did not organize their society within fixed, mutable concepts of positional understanding of masculine or feminine, but in the sense of balance, and acknowledged other possibilities of existence in between being male or female [5, 6, 7, 8, 9]. Both in human and animals, there has been recognition in diversity and transformative powers in the early times of society [1, 10, 11]. These societies had their own narratives on sex development and these remained throughout time.
Western narratives in sex and development have origins that can be traced back to medical and nonmedical philosophers over the last 2000 years. In Particular, the ideas from Aristotle, Plato, and Galen were influential medical thought on sex and development [12]. The ideas of how sex developed by these medical minds are somewhat strange today but set the early beginnings of scientific and medical understanding of sex development from the seventeenth century [12, 13]. For example, Aristotle did not see men and women as identical but nor did he see them as polar opposites [12]. Through the expansion of the Roman Empire, there was a strong influence of religious ideals of sex which had held until the seventeenth century. Of interesting note, and seldom discussed of Western thought, intersex people have been used to understand the true nature of sex and what it could or should mean and understanding normal and abnormal development [14].
From the seventeenth century with pioneering new medical and scientific technologies, it was possible to understand sex diversity in its elements such as genetics and chromosomes, hormones, enzymes, anatomy such as genitals and gonads, and the many others. These have been important to understanding how sex develops. This chapter does not intend to reproduce detail of each of these in defining what they are, their variations, and involvement in development. There are many textbooks and articles explaining each of these.
The chapter focuses on the narrative of the understanding of sex and development. Science as with every area of life is explained and understood through narratives. Facts never speak for themselves, rather they are understood within schemas and worldviews through those narratives. Sex and development is a good example of one such point. Science has demonstrated much diversity is the elements considered to make up sex – chromosomal, genetic, gonadal, internal genital, external genital, pubertal, and psychological [13]. These have been understood for some time now. Sex development through the elements of sex is understood through narratives, and these narratives affect people’s lives, physically, psychologically, and socially. Biologist Joan Roughgarden asks how do two fertilized eggs that start out looking about the same end up producing two adults as different as a man or woman, drag queen, or CEO [11]. How we understand the question and how it is narrated is of interest in this chapter. What is called normal and how it affects people who are outside normal is also important.
From narratives taught at school through to academic articles and books, the idea that biology controls development of the body. It is seen as a natural, biological process that begins from the joining of the two gametes – the egg and the sperm. From this point, a linear development progression begins that leads to a human being. It is that developing body that interacts with society. The chapter identifies how the current narratives either reinforce a biological essentialism or diminish the importance of biology in the narrative through social constructionism. There are issues with narrating through a biological essentialism of sex while also using a social construction of gender. Development cannot be reduced to either.
Rather the chapter focuses on the need to consider an alternative version of develop that is not focused on development like a mechanism nor as a social construction of development. The alternative is one of sex/gender narrative of becoming. It is a means of embodiment as through embodied being becomes from pre-birth through death. It is a narrativity of becoming that recognizes both a biological and social, and cultural being interacting with the surrounding environment.
The purpose of the chapter is not to debate the physiology, but how the narratives of these in development occur. It will do so through the differentiating between sex development or sex becoming. As the chapter will illustrate, the difference in the narrative is the difference of how people react to the body and the outside world throughout their life and also how medicine and society reacts to people of sex/gender diversity.
Before continuing on the focus of sex and gender development, it is important to have a brief discussion of particular framings that have been utilized in interpreting sex development. These framings have often limited discussion and the historicity of such framings have often either been ignored or been forgotten in relation to discussion of sex development.
The two framings of focus here that influence the discussion of sex development are biological determinism and social constructionism. The influences of both of these have had political impact on the biological and social lives of people over the last many hundreds of years. In particular, these framings have had negative impact on diversity of sex and gender. It is important to break these down to understand the nuggets of truth in them, if there are any, and separate from issues to have oppressed groups of people.
Biological determinism is the basic idea is that there is an underlying true essence that discontinues between forms of the essence and has a constancy in the absence of change over time (p. 13) [15]. Biological determinism represents the claim that the present states of human societies are the specific result of biological forces and the biological “nature” of the human species [16]. Biological determinism refers to the idea that human behavior originates in and is dictated by biological entities or processes, either innate or constitutional (p. 16) [17]. The essence indicates that certain phenomena are natural, inevitable, universal, and biologically determined, and any variation is attributed to the imperfect manifestation of the essences (p. 10) [15].
Biological determinism of sex thus is the criteria that determine as two discrete true forms – male and female – with no overlap or ambiguity. The biological traits (genetic, hormonal, neuro-atomical, and so on) determine a person’s sex as male or female development through life (and holds their place in social life) with a heterosexual orientation (p. 10) [15]. Furthermore, it suggests that not only the biological traits, but also psychological and orientation reside within the individual as essence of their being (p. 13) [15].
Cultural determinism is another form believing that there are determinist attributes of being male or female that continues the Western ideals, for example, through gender. Gender is the viewpoint that women and men do differ because of socialization and that women are at least equal to and possibly superior to men [19]. It is another way to foil for biological determinism except for the biological but including virtually everything in the human social world such as capitalism, colonialism, urbanism, poverty, sexism, racism, social structure, imperialism, family structure, and an assortment of other social, economic, and political variables [18].
Social constructionism is the any social influence on individual experience [15]. Burger and Luckman propose that reality is socially constructed, and that the sociology of knowledge must analyze the process in which this occurs [20]. Social constructionism is not the trait of the individual such as taken from an essentialist position. Social constructionism sees it as a process external to the individual [15]. It suggests that the power and structures have control over the individual, and their traits are non-consequential. Moreover, while essentialists suggest universal values, social constructionists acknowledge there may be some universal traits, but there is no universal standard for such traits (p. 15) [15].
Social constructionism is often reflected through the notion of gender and development. The idea is that gender is not reliant on biological development, but the social structures in which the individual develops. It is not the gendered traits of the individual but the result social processes that are external to the individual that impact upon any traits of the individual [15]. Gender is defined by interactions between people, by language, and by the discourse of a culture [15]. Rather than conceiving of sexuality as an unchanging individual essence that we might trace over time, we can investigate its contingency upon historically specific frameworks of thought and practice (p. 91) [21].
Sex and gender development is still framed as both oppositional and disembodied. Like many concepts referred to in the nineteenth and twentieth centuries, they are seen as either/or concepts. While one framing focuses on biology or physiology drives development and behavior, the other framing disregards it in favor of the social and institutional derivation.
Basing sex/gender development in either biological determinism or social constructionism is both misleading and has negative impact on people, but especially those who do not fit within the ideals of male or female. Intersex and transgender people who have had various names over the years have been the most severely impacted through these framings and still continue till today. Both deny or ignore critical elements of how human beings become who they are.
Though Western feminists in particular long criticized the notion that the behavior and abilities of women are uniquely determined by their biology [22], they adopted the social constructionist framing established by medical professionals from psychological theory – plasticity thesis. While trying to overcome being bounded by biology, they shift the focus from biology to psychology, while maintaining the oppositional binary of being male or female.
What these narratives of biological determinism and social constructionism indicate are binary understandings and how the Western concepts of opposition hold in discourse. Science in all of its forms from biological through social science has been influenced by such discourses. Science is a process of narrating around the discover of facts and evidence. In itself, it is a set of information that is available to be women into narratives. These narratives are also influenced by ideologies and their worldview. It is time for a different discourse that recognizes truths while not essentializing individuals into a particular structure and form. It is also necessary to understand that people are not just machines open to receiving and performing or adopting social structures.
Though a person’s biology does not define a person’s life, it is still very important in the development of a person. The consideration of biology as a mechanical system or a controlling essence do a disservice to the embodiment of people and their life experience. The implicit denial of the biological events of our lives has also failed to appeal to people’s ideas of “common sense” [22]. At the same time, nonrecognition of the effects and/or interconnections of society and the environment also neglect major impacts on a person and development. Both determinism and constructionism in its forms deny connectedness and agency of the person and community.
Understanding the framing of sex/gender, it is now possible to begin to consider the narrating of the sex and gender development or becoming. Narrating is core to the human experience. Human beings are self-reflexive, narrative beings transformed its raw experiences into abstractions [26]. Becoming indicates a person with capabilities and agency, a life plan, make choices and responsible to others [27]. It is organic yet susceptible to significant environmental, social, and cultural influences, for example, it assumes that it includes meaning and is value laden [27].
Self-narration is an experience of temporal dimension that gathers events together into a coherent and meaningful structure that gives significance to the overall configuration, that is, the person [28]. Narration cannot be only understood in objective social categories, and these cannot adequately account for the lived dynamic aspects, rather resulting in reductive and reified understandings [28].
To ensure an illustrative difference, the chapter will discuss a difference between the development of sex and gender and (sex) becoming. The distinction is important as it illustrates how these narratives are written into people’s lives and what impact these narratives have.
Development since the early 1600s has been used to infer improvement, but for many individuals and collectives has resulted in quite the opposite. In terms of sex and gender, development implies a procedural sense or something being developed. It also indicates that such processes will follow linear paths from the beginning to the end. There is a determinist connotation within development and questions as to whether there is agency or autonomy possible in development. Development also suggests that that any deviations from the linear development processes are abnormalities. A clear example of such deviations is a population referred to as having disorders of sex development [29]. While there is a diversity of possibilities of the various biological parts of becoming, those not part of the ideal type are considered out of the normal, abnormal, or atypical.
In contrast, becoming is used to suggest organic nature of “becoming a person.” Becoming involves more than an individuated process. It has a multitude of influences and interconnections from the social, spiritual/cultural, and environmental embodiment of the person. Further, individual becoming always involves and is part of community sustenance and identity. Becoming is ongoing with the possibility of transformation from pre-birth through death. It is not linear nor immutable. Becoming is a narrativity of the socialized sex through the embodied physiological being with the surrounding community and context depending world.
This part of the chapter will discuss sex and gender development and the differences and similarities. It will also set out how biological determinism and social constructionism are or are not embedded in sex/gender development. It will then move to sex becoming and how that differs from sex/gender development.
To begin with, it is important to briefly describe the common narrative of sex and sex development. The common narrative also indicates particular understandings of what is abnormal, even disease, and outside of the common narrative. These variations outside of the norm have had impact on people outside of the standard ideal of the heterosexual male or female.
The narrative of sex/gender and its development must begin with the structures upon which it is based. That is, there is a norm, a standard pattern all life follows and that norm states that sex is an oppositional binary of being male or female with the male includes particular biological characteristics while the female has other characteristics. There are other general characteristics that are shared between the two – males and females.
The narrativity of sex development has an assumed foundation of an egg representing female and a sperm representing male. These are discrete and oppositional and the only possibilities. Females have XX chromosomes and particular physiology while males have XY chromosomes and particular physiology distinct from females. There are three core assumptions: it is binary (two different forms, male and female) which have distinct anatomical structures and biological functions; each form has different physical characteristics; and each form has different psychological and behavioral characteristics [30, 31]. There are two different species as male and female and not just two different reproductive systems (women have ovaries, a womb, and lactate while men are sperm producers) [32, 33, 34]. There are many texts defining these differences. Outside of these are mistakes of nature or abnormalities.
Sex development begins as process-based and linear. The very beginning of development is where the egg and the sperm meet and the egg provides an X and the sperm either an X or Y chromosome. Depending on what gene is provided from the sperm, X or Y, will determine if the newly formed zygote is a male or female. The zygote then begins the development process into either male physiology or female physiology. The presence of a Y chromosome makes the embryo develop as a male (individuals with Y will develop testes); in its absence, the default development is along the female pathway (ovaries will develop) [33]. Sex development theory assumes a master template (a master gene) as the norm that triggers a subordinate gene which cascades to downstream genes in a descending hierarchy of control [11]. As an analogy, development occurs as though a bowling ball was accurately rolled to hit a genetic kingpin at just the right spot and cause all the genetic bowling pins behind to fall down in perfect order and producing a normal baby is bowling a genetic strike [11]. This assumes there is a close linear association of “3G” sex – genetic, gonadal, and genitals – as core markers of sex [33]. The sex will then lead to the direction of other related sex characteristics. The chromosomes lead to a linear development of other anatomical structures including those often referred to as sex structures (e.g. ovaries, testes, uterus, scrotum, vagina, and clitoris) and most importantly the brain and the neural system [35].
From the time of birth, the linear development continues along the chromosomal pathway albeit at a slower pace until puberty. At puberty, sex development continues with “secondary sex characteristics” of body hair, breasts, voice, pitch, menstruation, and sexual sensations and desires [13, 35, 36]. One’s biological sex further develops into adulthood. Later in life, other factors change such as menopause in women. Up till recently, it has also been assumed that this determined sex will also determine one’s sexual relations, and hence the system of heterosexuality.
Development assumes an oppositional binary whereby from chromosomes to hormones to gonads to secondary sex characteristics there are only two choices: male (XY) or female (XX). The assumption is social sex social roles and function, expression follows on from sex development as male or female as biology established [37]. In another words, sex is understood here as a status determined by nature that unfurls into sociopolitical roles. Sex is so fundamental in the developmental program and experience is secondary to that of development in forming the male brain and male nature, or to a female brain and female nature [33].
The general sex development theory at its core is biological determinism. It infers that social development derives from the biological essence. The narrative imposed on these development systems upholds the oppression based on biological systems. It also maintains that any variation and difference is abnormal or not socially acceptable.
Prior to the 1950s, the term gender was not used, and social roles, expressions, and others relations to sex came within the umbrella of the term “sex.” The assumption was that the development of biology would extend to the developing of matching social roles and expressions and so on of society. When held strictly to such ideas, it became biological essentialism in that the person’s biology dictated the person’s position and function in society. Enforcement of biological determinism has led to sex oppression over the years, which has been often centered through patriarchy. Biological determinism of race and sex which began in the seventeenth century was recognized as having large social repercussions, especially for women and people of sex diversity [38]. Feminists have long criticized biological determinism that subordinated women to the behavior and abilities of women uniquely determined by their biology [22].
Gender as a concept and understanding arose with the rise of plasticity of human being [24]. The psychological theory posited that human beings are malleable or there is a plasticity of human beings [24]. This was the idea that humans are malleable beings and not fixed and subordinated to biological traits such as race and sex. It has its roots in the work of Konrad Lorenz concept of imprinting into dominance and adopted by Dr. John Money in establishing gender to imprint intersex people into the male–female binary [23]. The biological morphology (outer (and sometimes inner)) body was malleable and alterable [25]. The intersex and transgender persons’ bodies were alterable to fit the assigned or re-assigned gender. Dr. Robert Stoller extended the concept of gender to suggest that once a gender was assigned at birth, biology virtually superfluous except to medical professionals and produced the raw material (linear development) upon which gender developed which became known as the sex/gender split [23, 25, 39, 40, 41, 42].
Gender indicated that irrespective of the diversity of biology, a person’s development began from the assignment of gender at birth along with any necessary alteration of biology to match that assignment. A person’s gender identity derives from an inner sense of self – the psychological self – that usually matches the assignment at birth [23, 39, 43]. That sense of self develops social cues around them into the masculine and feminine person they were assigned to be. Gender development enables a concentration on the development psychological phenomena such as thoughts, behavior, and personality [23, 39]. A person has the ability to take roles that are not based on their biology in society and therefore be equal to each other – that is equality of man and woman (at least in theory). Gender development is the way a person perceives, expresses, and experiences sex identity within social relations of a social-political environment through imposed expectations (such as getting married and having children), norms, qualities, and behaviors upon an individual which vary across history societies, cultures, and classes [11, 44, 45, 46, 47, 48, 49]. Gender development is a complex process within the sociopolitical world. It is an integration of one’s “inner sense of being male or female” experienced within the sociopolitical expectations and is influenced by other’s view of themselves [50].
Gender development begins at the time of birth, though some cues are even learnt pre-birth. Late in the pre-birth process, the fetus recognizes cues of acceptability within society of what it means to be their gender [51, 52]. After birth and by the age of 5 years, a child recognizes their gender; however, the child also recognizes the what gender recognition is acceptable or needs to be concealed/suppressed within the social setting and expects them to be [53, 54]. Through the early years, the infant continues to pick up those cues around them. As the child develops, they encounter endless gender clues and hints in the real world including gender stereotypes, encouraging or discouraging words, expressions, or body language from others, and sex segregation of adult social roles [33]. These clues and hints are taken on board in the person’s gender development. Consciously or unconsciously, developing gender with its associated patterns of permitted freedoms is quickly understood including the boundaries of that gender [34].
From childhood onward, gender development is fortified through internal and external sense of their psychological self [13, 36]. Development includes socially appropriate cues of being male or female including the socially constructed roles, behavior, activities, and attributes [55]. Development is reinforced through carers, whether it is family or other members of society their own social interests in the child’s gender becoming are reinforced [56]. These considerations influence one’s inner sense of self as expectations about the characteristics men and women have, and as gender norms dictating double standards for how women and men should behave, influencing people’s interests, self-concept, performance, and beliefs about capabilities in gendered domains [33].
Moreover, as one matures, one continues to author gender as cued by relationships, society, and sociality [56]. This continues with the child as their status as sex determined, and gender authored. This becomes their sociopolitical status of life which is not escapable. It is central to and entangled within one’s social and legal life of recognition and relationality. At an early age, they pick up on cues about acceptable and non-acceptable relationships, even though they yet may not know their favored sexual relationships [53, 54]. As they turn to their teens, they begin to form relationships usually favoring culturally accepted values, such as heterosexual [53, 54]. The infant uses these ques. as a guide together with the gendered world around them in becoming their gender. These relationships primarily adhere to the sociopolitical way of life.
Gender introduced by Western feminists into the public sphere derived from and was based in the work of Dr. John Money and Dr. Robert Stoller. They accepted that through gender it was possible to socialize a person into an assigned sex stable sexed subject [23]. The focus of the theory was to normalize intersex and transgender people into the male female binary as they were creating ambiguity of the two-sex system. The sex/gender split introduced by Dr. Stoller was essential to feminist work. Removing biology as the root of the diversity enabling a capturing of these populations and normalizing them with the binary, oppositional system. Moreover, gender did not interfere with the broader institutional, patriarchal system, but only remove biology as an essence upon which it was built. This enabled women to be equal in social and psychological development as men. It was this idea that feminists adopted introducing gender into the public sphere [23, 39].
Western science has had an interesting relationship with biological diversity. As far back as the Greeks such as Aristotle and Plato, there was recognition of the diversity of being beyond male or female even though there was little acceptance of them as full human beings [12, 14]. Since the modern science period, there has been a large discovery of various diversities of sex and gender.
Sex development and diversity are not generally considered as possibility. When sex development ranged beyond the standard norm, they as considered as abnormal sex development. Though sex diversity was not fully accepted, especially in the West, under various names people we call intersex and transgender people today still existed.
Due to greater awareness of biological diversity and social unrest of norms including increasing awareness and recognition of gays and lesbians, and fear of communism, there was a need to protect the binary and diminish and erase diversity [23]. Gender was such an institution to remove sex and maintain the binary including its meaning and basis in society. Dr. John Money established gender it was to erase the possibility of intersex people and ensure they conform to being male or female to fit into society. He believed that in spite of the physiological characteristics, intersex children were malleable and could be assigned a gender – male or female – and raised accordingly [57]. Once assigned, there may be necessity to change the child’s body to match the assignment – completing what nature did not finish – and encourage child and parent bonding and development of gender [25].
Dr. Robert Stoller also worked with Money’s notion of gender in his work with transgender people. Transgender was earlier understood as a biological reality, but this was transformed by Stoller as an independent psychological phenomenon (p. 31) [23]. The development of gender identity as a psychological reality shifted sense of embodiment that transgender people once had (p. 99) [25]. Though transgender people may have desired transformative support of particular biological parts, they still would relate to the world through their body. The focus of gender changed that indicating that the relationship was through their psychological being.
Both for intersex and transgender people, they were seen as diseased and in need of a cure [11]. By fixing these groups, they could live successful lives in society. Such an implementation of social construction upon the bodies and lives of these groups was still rooted in biological determinism – the belief that there are only two human which are male or female.
Though gender was an attempt to overcome the problems of biological determinism, through using social constructionism, it is questionable to what extent it has done so. Gender and its development are underpinned by cultural determinism based in the male and female ideal (minus the control of biology). It has not freed society of the shackles of the binary understanding of the world as an immutable state and erased diversity. Though there is a use of the term gender diversity, it is in the sense of social constructionism and not including biological diversity such as intersex people exemplify nor does it provide for and enable embodiment.
The development of sex and gender indicated a linear process of development as either male or female. Any deviation was a developmental error. This has led to nonrecognition of people who are no longer recognized as a person without the help of medicine to rehabilitate them into the standardized norm as a male or female, even if it was the opposite to that assigned at birth (as with transgender people).
Narrativity of becoming is not just a different name but indicates a different way to understand a narrative of how a person becomes who they are. As mentioned earlier, it is organic interaction and interconnections of their embodied being within a social-cultural and environmental place. Embodiment moves beyond the body as a bodily form to a conception that through the body provides realms of agency, practice, custom, and so on [58]. It infers social relationality and connectedness – a sense of belonging. Embodiment indicates the agency and experience of the world through a person’s bodily form, mediated from physiology within and the cultural, social, political, and environmental world without [58]. Becoming throughout their life is inclusive of overlapping and intersecting multiplicities such as sex/gender, race, ethicality, class, (dis)ability, and so on. Becoming is a process of evolving, reinventing, or transforming nature. [62]. It is a mediation between stasis and change [28, 63] where nothing is resolved or in closure, yet often contradictory as it accommodates the emergence of new possibilities or transformations of the whole and the parts of one’s becoming [50, 62, 63, 64, 65, 66].
The very beginning of sex becoming is prenatal. As various physiological interactions begin, there are decisions made as to “pathways” of becoming of the future being. Each physiological part of a person is a the consequence of dozens of different genes and numerous pathways by which cells are assembled, differentiated, and assigned alternate functions in sex becoming [13]. Even chromosomes do not operate in isolation but require certain biochemicals called enzymes to makes the genes effective [11]. As Joan Roughgarden suggests as analogy, it is like a committee (chromosomes, hormones, enzymes, and other physiological members) that meets throughout becoming even at the early physiology stages before society and culture even have become part of the person’s becoming [11]. This analogy is important to indicate that diversity in biology and physiology is important in becoming but is not an automatic process but organic with multiple possibilities.
The processes continue from the time of birth. The only difference is that from the time of birth the social, cultural, and environmental members of the committee have more voice on the committee that they had pre-birth to continue the analogy further. Becoming continues through childhood, adolescence into adulthood. Even late into the later stages of life becoming, or even slowing of life, continues. Becoming is a recognition of the interconnectedness not only of the people around them but also the land from which they derive.
Sex becoming is the embodiment of being and belonging as male, female, both, or neither relating how they see themselves, and how they think others see them, in performing social roles, expressions, and functions through their biological body [51, 59, 60, 61]. Such a becoming enables people to connect with their spiritual and cultural ancestral beings and contribute to overall human potentiality and community sustenance and identity. Although sex becoming will always in and through social relations, the relations will not necessarily completely define us where reciprocity exists and there is respect for uniqueness of being.
Becoming is organic enables transformative possibilities. Though it recognizes biological and physiological importance, it is not as a controlling force as in biological determinism. Rather, it is in the sense of embodiment, that is through the body (whether it is in the form that one is born with or has been transformed due to medical necessity or gender-confirming need) with the social and environmental interconnectedness. What becomes clear is social constructionism does not provide the basis for embodiment and interconnectedness but leads back to a type of determinism.
The aim of this chapter was not to go through the various biological mechanisms involved in sex development. As mentioned near the beginning, there are numerous texts out there providing eloquent discussions of the various parts and their functions in the development process.
Rather, the chapter has aimed to focus on the narratives used in describing the development process. All facts are only understood when incorporated within a narrative. As noted in the chapter, all meaning is understood through narratives. Whether in early times, in the modern era, or the technological era, narratives are how humans understand the world. It is through these narratives that it is possible to indicate what something is worth and how it is valued. The narratives are also central to social organization and understanding how a person fits into the world around them and what functions they may have within society.
Sex and gender development narratives are bound within narratives that have been maintained over many years through religious and scientific dominions. The early understanding was through early form and the more direct biological determinism. Though it has largely been debunked regarding race, there is still a strong support for such ideas today regarding sex and sex development. Many of the texts do not use the words today but when read contextually still maintain such a theory.
The introduction of social constructionism, however, was aimed to curve the impact of sex determinism, or at least that is how some in the gender studies have argued. The idea of social constructionism is that biology should not and does not control destiny. Though there was oppression linked to biology as destiny, and hence the purpose for introducing social constructionism, at the same time it has led to the abandonment of embodiment. Furthermore, in particular for sex/gender development has been implemented as the same ideology as a binary, oppositional system of male and female only not based on biology determining future roles and functions of people. The result has been a cultural determinism and enforcement of a Western ideal of what is means to be male or female and the spreading of its particular narrative of sex/gender development.
The group or population that has suffered the most of both of these ideas has been those of sex/gender diversity. While under sex biological determinism has led to limited or no recognition and acceptance, under social constructionism it led to enforced transformation into assigned or reassigned genders which often also involved changing the morphology of the body to match their newly assigned genders. A greater impact for both intersex and transgender people was the loss of embodiment as the move to gender concentrated a person’s knowledge and sense of oneself was based in their psychology. Not only did it deny a relationship with the person’s body and being, but also it was an individualizing process separating people from community and connectedness. The effect of social constructionism, or even it could be argued cultural determinism, was a loss of ability to develop a diversity of being, for example as intersex or transgender, that was outside of the framing of maleness or femaleness.
Realizing development as a becoming enables a return to embodiment. It is a relation to the body (even if it be transformed from that at birth) and at the same time, a relatedness to the social and environmental world around them. Mover, becoming was organic, not linear nor immutable. It provided a means of agency yet still had bounds of social and cultural responsibility.
Understanding development as becoming recognized the complex organic being with multiple interconnected communicating with each other. From both internal and external directions, the physiological, social, psychological, and cultural multiplicities communicate and discuss at various stages of becoming of what possibilities there are and which direction to become. It is an ongoing process that continues through death where even some cultures would suggest that some of these multiplicities continue becoming in some way.
Becoming does not deny that there are external forces, yet at the same time recognizes that agency derives through the embodied being, and not simply a psychological sense of self. It is a means of acknowledging a cultural and spiritual connectedness of being along with its collective identity rather than the individualized and atomized notion of being. Becoming is a narrativity of the socialized sex through the embodied physiological being with the surrounding community and context depending world.
Understanding development through a different paradigm does not deny biological or physiological reality but does change the narrative of how life, society, and the surrounding environment connect and organize together. It provides a narrative of cohesiveness yet respect for difference and uniqueness, while individuals have duties to one another. As such, it provides a space of relationality rather the separateness and individuality that derives from sex/gender development.
The author declares no conflict of interest.
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\n\n\n\nBook Chapters and Monographs
\n\nThe Claremont Colleges are pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\n\nCorresponding authors will receive a 15% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\n\nThe University of Massachusetts, Amherst is pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\n\nCorresponding authors will receive a 10% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\n\nThe University of Surrey is pledging funds via the Knowledge Unlatched program to ensure academics can publish Open Access content more easily.
\n\nCorresponding authors will receive a 10% discount on their Open Access Publication Fees (OAPF) for Open Access book chapters or monograph publications. To use the discount you will need to verify your institutional email address. These discounts are valid from 2020 to 2022.
\n\nMonographs Only
\n\n\n\nImportant: You must be a member or grantee of the above listed institutions in order to apply for their Open Access publication funds.
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Unfortunately, the comorbidities of aging have created a large economic and health burden on society. Osteoporosis is the most prevalent age-related disease. It is characterized by uncoupled bone resorption that leads to low bone mass, compromised microarchitecture and structural deterioration that increases the likelihood of fracture with minimal trauma, known as fragility fractures. These fractures lead to disproportionally high mortality rate and a drastic decline in quality of life for those affected. While estrogen loss is one known trigger of osteoporosis, a number of recent studies have shown that osteoporosis is a multifactorial condition in both humans and rodent models. The presence or absence of certain factors are likely to determine which subset of the population develop osteoporosis. 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Therefore, the objective of this chapter is to describe the use of these parameters as an auxiliary mechanism in the detection of low bone mineral density, as well as to characterize the radiographic findings of patients with osteoporosis.",book:{id:"10323",slug:"osteoporosis-recent-advances-new-perspectives-and-applications",title:"Osteoporosis",fullTitle:"Osteoporosis - Recent Advances, New Perspectives and Applications"},signatures:"Plauto Christopher Aranha Watanabe, Giovani Antonio Rodrigues, Marcelo Rodrigues Azenha, Michel Campos Ribeiro, Enéas de Almeida Souza Filho, Rafael Angelo Soares Vieira and Fabio Santos Bottacin",authors:[{id:"76171",title:"Prof.",name:"Plauto C. A.",middleName:null,surname:"Watanabe",slug:"plauto-c.-a.-watanabe",fullName:"Plauto C. A. 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Anti-inflammatory diet is designed to improve health and prevent the occurrence and development of chronic diseases associated with inadequate diet. Proper nutrition is based on the anti-inflammatory pyramid and changes in poor eating habits are the long-term strategy for preventing inflammation and chronic diseases. Inflammatory factors from food may play a role in the development of osteoporosis and an anti-inflammatory diet may be a way to control and reduce long-term inflammation and prevent bone loss. Pro-inflammatory cytokines from the fat tissue, through activation of the RANKL/RANK/OPG system could intervene with bone metabolism in a way of increased bone loss. Therefore the special attention need to be given to obese patients due to twofold risk, one related to pro-inflammatory cytokines release and the other related to the deprivation of the vitamin D in the fat tissue.",book:{id:"10323",slug:"osteoporosis-recent-advances-new-perspectives-and-applications",title:"Osteoporosis",fullTitle:"Osteoporosis - Recent Advances, New Perspectives and Applications"},signatures:"Olga Cvijanović Peloza, Sandra Pavičić Žeželj, Gordana Kenđel Jovanović, Ivana Pavičić, Ana Terezija Jerbić Radetić, Sanja Zoričić Cvek, Jasna Lulić Drenjak, Gordana Starčević Klasan, Ariana Fužinac Smojver and Juraj Arbanas",authors:[{id:"339281",title:"Associate Prof.",name:"Olga",middleName:null,surname:"Cvijanović Peloza",slug:"olga-cvijanovic-peloza",fullName:"Olga Cvijanović Peloza"},{id:"346420",title:"Prof.",name:"Sandra",middleName:null,surname:"Pavičić Žeželj",slug:"sandra-pavicic-zezelj",fullName:"Sandra Pavičić Žeželj"},{id:"346421",title:"BSc.",name:"Ivana",middleName:null,surname:"Pavičić",slug:"ivana-pavicic",fullName:"Ivana Pavičić"},{id:"346423",title:"Prof.",name:"Ana Terezija",middleName:null,surname:"Jerbić Radetić",slug:"ana-terezija-jerbic-radetic",fullName:"Ana Terezija Jerbić Radetić"},{id:"346424",title:"Prof.",name:"Sanja",middleName:null,surname:"Zoričić Cvek",slug:"sanja-zoricic-cvek",fullName:"Sanja Zoričić Cvek"},{id:"346426",title:"MSc.",name:"Jasna",middleName:null,surname:"Lulić Drenjak",slug:"jasna-lulic-drenjak",fullName:"Jasna Lulić Drenjak"},{id:"346427",title:"Prof.",name:"Gordana",middleName:null,surname:"Starčević Klasan",slug:"gordana-starcevic-klasan",fullName:"Gordana Starčević Klasan"},{id:"346428",title:"MSc.",name:"Ariana",middleName:null,surname:"Fužinac Smojver",slug:"ariana-fuzinac-smojver",fullName:"Ariana Fužinac Smojver"},{id:"346429",title:"Prof.",name:"Juraj",middleName:null,surname:"Arbanas",slug:"juraj-arbanas",fullName:"Juraj Arbanas"},{id:"350011",title:"Dr.",name:"Gordana",middleName:null,surname:"Kenđel Jovanović",slug:"gordana-kendjel-jovanovic",fullName:"Gordana Kenđel Jovanović"}]},{id:"76351",doi:"10.5772/intechopen.97416",title:"Glucocorticoid-Induced Osteoporosis",slug:"glucocorticoid-induced-osteoporosis",totalDownloads:246,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The use of glucocorticoids (GC) in the medium and long term, causes several considerable side effects, being one of the main ones the reduction of bone mineral density (BMD). Prolonged corticosteroid therapy reduces BMD by up to 20% in trabecular bone and approximately 2–3% in cortical bone in the first year of use. This loss rate declines and stabilizes at approximately 2% in subsequent years. Therefore, there is a considerable increase in the incidence of pathological fractures, whether clinically symptomatic or asymptomatic (detected as a radiological finding), which varies between 30 and 50% of patients who use GC for more than three months. In view of the above, it is essential to prevent fractures and treat osteoporosis in patients using glucocorticoids for long periods (in particular, greater than or equal to 3 months), which may or may not be associated with clinical risk factors or previous fractures. The guidelines for the treatment and prevention of this comorbidity are well established for postmenopausal women and men over 50 years of age. 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Unfortunately, the comorbidities of aging have created a large economic and health burden on society. Osteoporosis is the most prevalent age-related disease. It is characterized by uncoupled bone resorption that leads to low bone mass, compromised microarchitecture and structural deterioration that increases the likelihood of fracture with minimal trauma, known as fragility fractures. These fractures lead to disproportionally high mortality rate and a drastic decline in quality of life for those affected. While estrogen loss is one known trigger of osteoporosis, a number of recent studies have shown that osteoporosis is a multifactorial condition in both humans and rodent models. The presence or absence of certain factors are likely to determine which subset of the population develop osteoporosis. In this chapter, we review the factors that contribute to osteoporosis with an emphasis on its multifactorial nature and the therapeutic consequences.",book:{id:"10323",slug:"osteoporosis-recent-advances-new-perspectives-and-applications",title:"Osteoporosis",fullTitle:"Osteoporosis - Recent Advances, New Perspectives and Applications"},signatures:"Di Wu, Anna Cline-Smith, Elena Shashkova and Rajeev Aurora",authors:[{id:"339667",title:"Associate Prof.",name:"Rajeev",middleName:null,surname:"Aurora",slug:"rajeev-aurora",fullName:"Rajeev Aurora"},{id:"347366",title:"Mr.",name:"Di",middleName:null,surname:"Wu",slug:"di-wu",fullName:"Di Wu"},{id:"347367",title:"Ms.",name:"Anna",middleName:null,surname:"Cline-Smith",slug:"anna-cline-smith",fullName:"Anna Cline-Smith"},{id:"347579",title:"Dr.",name:"Elena",middleName:null,surname:"Shashkova",slug:"elena-shashkova",fullName:"Elena Shashkova"}]},{id:"75742",title:"Osteoporosis and Dietary Inflammatory Index",slug:"osteoporosis-and-dietary-inflammatory-index",totalDownloads:230,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Healthy bones are constantly being renewed and proper nutrition is an important factor in this process. Anti-inflammatory diet is designed to improve health and prevent the occurrence and development of chronic diseases associated with inadequate diet. Proper nutrition is based on the anti-inflammatory pyramid and changes in poor eating habits are the long-term strategy for preventing inflammation and chronic diseases. Inflammatory factors from food may play a role in the development of osteoporosis and an anti-inflammatory diet may be a way to control and reduce long-term inflammation and prevent bone loss. Pro-inflammatory cytokines from the fat tissue, through activation of the RANKL/RANK/OPG system could intervene with bone metabolism in a way of increased bone loss. Therefore the special attention need to be given to obese patients due to twofold risk, one related to pro-inflammatory cytokines release and the other related to the deprivation of the vitamin D in the fat tissue.",book:{id:"10323",slug:"osteoporosis-recent-advances-new-perspectives-and-applications",title:"Osteoporosis",fullTitle:"Osteoporosis - Recent Advances, New Perspectives and Applications"},signatures:"Olga Cvijanović Peloza, Sandra Pavičić Žeželj, Gordana Kenđel Jovanović, Ivana Pavičić, Ana Terezija Jerbić Radetić, Sanja Zoričić Cvek, Jasna Lulić Drenjak, Gordana Starčević Klasan, Ariana Fužinac Smojver and Juraj Arbanas",authors:[{id:"339281",title:"Associate Prof.",name:"Olga",middleName:null,surname:"Cvijanović Peloza",slug:"olga-cvijanovic-peloza",fullName:"Olga Cvijanović Peloza"},{id:"346420",title:"Prof.",name:"Sandra",middleName:null,surname:"Pavičić Žeželj",slug:"sandra-pavicic-zezelj",fullName:"Sandra Pavičić Žeželj"},{id:"346421",title:"BSc.",name:"Ivana",middleName:null,surname:"Pavičić",slug:"ivana-pavicic",fullName:"Ivana Pavičić"},{id:"346423",title:"Prof.",name:"Ana Terezija",middleName:null,surname:"Jerbić Radetić",slug:"ana-terezija-jerbic-radetic",fullName:"Ana Terezija Jerbić Radetić"},{id:"346424",title:"Prof.",name:"Sanja",middleName:null,surname:"Zoričić Cvek",slug:"sanja-zoricic-cvek",fullName:"Sanja Zoričić Cvek"},{id:"346426",title:"MSc.",name:"Jasna",middleName:null,surname:"Lulić Drenjak",slug:"jasna-lulic-drenjak",fullName:"Jasna Lulić Drenjak"},{id:"346427",title:"Prof.",name:"Gordana",middleName:null,surname:"Starčević Klasan",slug:"gordana-starcevic-klasan",fullName:"Gordana Starčević Klasan"},{id:"346428",title:"MSc.",name:"Ariana",middleName:null,surname:"Fužinac Smojver",slug:"ariana-fuzinac-smojver",fullName:"Ariana Fužinac Smojver"},{id:"346429",title:"Prof.",name:"Juraj",middleName:null,surname:"Arbanas",slug:"juraj-arbanas",fullName:"Juraj Arbanas"},{id:"350011",title:"Dr.",name:"Gordana",middleName:null,surname:"Kenđel Jovanović",slug:"gordana-kendjel-jovanovic",fullName:"Gordana Kenđel Jovanović"}]},{id:"76351",title:"Glucocorticoid-Induced Osteoporosis",slug:"glucocorticoid-induced-osteoporosis",totalDownloads:248,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The use of glucocorticoids (GC) in the medium and long term, causes several considerable side effects, being one of the main ones the reduction of bone mineral density (BMD). Prolonged corticosteroid therapy reduces BMD by up to 20% in trabecular bone and approximately 2–3% in cortical bone in the first year of use. This loss rate declines and stabilizes at approximately 2% in subsequent years. Therefore, there is a considerable increase in the incidence of pathological fractures, whether clinically symptomatic or asymptomatic (detected as a radiological finding), which varies between 30 and 50% of patients who use GC for more than three months. In view of the above, it is essential to prevent fractures and treat osteoporosis in patients using glucocorticoids for long periods (in particular, greater than or equal to 3 months), which may or may not be associated with clinical risk factors or previous fractures. The guidelines for the treatment and prevention of this comorbidity are well established for postmenopausal women and men over 50 years of age. However, for patients below this range, studies are still lacking.",book:{id:"10323",slug:"osteoporosis-recent-advances-new-perspectives-and-applications",title:"Osteoporosis",fullTitle:"Osteoporosis - Recent Advances, New Perspectives and Applications"},signatures:"José Renan Vieira da Costa Júnior and Sérgio Luchini Batista",authors:[{id:"164388",title:"Prof.",name:"Sergio",middleName:null,surname:"Luchini Batista",slug:"sergio-luchini-batista",fullName:"Sergio Luchini Batista"},{id:"354032",title:"Dr.",name:"José Renan",middleName:null,surname:"Vieira Da Costa Júnior",slug:"jose-renan-vieira-da-costa-junior",fullName:"José Renan Vieira Da Costa Júnior"}]}],onlineFirstChaptersFilter:{topicId:"1414",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). 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Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. His research interests include biochemistry, oxidative stress, reactive species, antioxidants, lipid peroxidation, inflammation, reproductive hormones, phenolic compounds, female infertility.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. 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