\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8095",leadTitle:null,fullTitle:"Liposomes - Advances and Perspectives",title:"Liposomes",subtitle:"Advances and Perspectives",reviewType:"peer-reviewed",abstract:"Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. The preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structures.The purpose of this book is to concentrate on recent developments in liposomes. The articles collected in this book are contributions by invited researchers with long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with a general background in many different biological sciences. This volume offers up-to-date, expert reviews of the fast-moving field of liposomes and is divided in two major sections: 1. Introduction; 2. Liposomes general properties",isbn:"978-1-78984-495-5",printIsbn:"978-1-78984-494-8",pdfIsbn:"978-1-83881-232-4",doi:"10.5772/intechopen.77926",price:119,priceEur:129,priceUsd:155,slug:"liposomes-advances-and-perspectives",numberOfPages:102,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"02b0d76190d551561ad19af0c80f98f2",bookSignature:"Angel Catala",publishedDate:"September 4th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/8095.jpg",numberOfDownloads:6981,numberOfWosCitations:40,numberOfCrossrefCitations:24,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:53,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:117,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 25th 2018",dateEndSecondStepPublish:"December 10th 2018",dateEndThirdStepPublish:"February 8th 2019",dateEndFourthStepPublish:"April 29th 2019",dateEndFifthStepPublish:"June 28th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"380",title:"Molecular Biology",slug:"biochemistry-genetics-and-molecular-biology-biochemistry-molecular-biology"}],chapters:[{id:"66574",title:"Introductory Chapter: Liposomes - Advances and Perspectives - My Point of View",doi:"10.5772/intechopen.85663",slug:"introductory-chapter-liposomes-advances-and-perspectives-my-point-of-view",totalDownloads:575,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Angel Catala",downloadPdfUrl:"/chapter/pdf-download/66574",previewPdfUrl:"/chapter/pdf-preview/66574",authors:[{id:"196544",title:"Prof.",name:"Angel",surname:"Catala",slug:"angel-catala",fullName:"Angel Catala"}],corrections:null},{id:"66763",title:"The Role of Water in the Responsive Properties in Lipid Interphase of Biomimetic Systems",doi:"10.5772/intechopen.85811",slug:"the-role-of-water-in-the-responsive-properties-in-lipid-interphase-of-biomimetic-systems",totalDownloads:1090,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"The lack of details in the hydration properties of lipid bilayers hinders the design of biomimetic systems that, as liposomes and vesicles, may be used for biotechnological and medical purposes. In this chapter, studies indicate water as a membrane dynamic component determining the affinity and response of lipid membranes to amino acids, peptides and others stimuli. Based on thermodynamic analysis in lipid monolayers and its comparison with swelling shrinkage processes in liposomes and vesicles, it is concluded that: (1) the interphase of a lipid bilayer in a bidimensional solution of hydrated polar groups imbibed in labile water can be exchanged with the media by osmosis and or expansion-compression. (2) Excess water beyond the hydration shell (confined water) has solvent properties for additives in the bulk water phase and confers free energy that is in excess for binding of amino acids and peptides. (3) Dissolution in the water membrane phase changes the water activity (aw) and affects the surface pressure. (4) Defects may be formed by the compression of bilayers in which carbonyl groups organized water differently. These studies indicate that a deeper understanding of the role of lipid bilayers in cellular biology and support the development of future lipid-based biotechnology that should necessarily include the role of water as a membrane dynamic component.",signatures:"Anibal Disalvo and Maria de los Angeles Frias",downloadPdfUrl:"/chapter/pdf-download/66763",previewPdfUrl:"/chapter/pdf-preview/66763",authors:[{id:"285313",title:"Ph.D.",name:"Anibal",surname:"Disalvo",slug:"anibal-disalvo",fullName:"Anibal Disalvo"},{id:"298166",title:"Dr.",name:"Maria",surname:"Frias",slug:"maria-frias",fullName:"Maria Frias"}],corrections:null},{id:"66369",title:"General Perception of Liposomes: Formation, Manufacturing and Applications",doi:"10.5772/intechopen.84255",slug:"general-perception-of-liposomes-formation-manufacturing-and-applications",totalDownloads:3256,totalCrossrefCites:16,totalDimensionsCites:38,hasAltmetrics:0,abstract:"Liposomes are currently part of the most reputed carriers for various molecular species, from small and simple to large and complex molecules. Since their discovery, liposomes have been subject to extensive evolution, in terms of composition, manufacturing and applications, which led to several openings in both basic and applied life sciences. However, most of the advances in liposome research have been more devoted to launching new developments than improving the existing technology for potential implementation. For instance, the evolution of the conventional lipid hydration methods to novel microfluidic technologies has permitted upscale production, but with increase in manufacturing cost and persistent use of organic solvents. This chapter intends to present general concepts in liposome technology, highlighting some longstanding bottlenecks that remain challenging to the preparation, characterization and applications of liposomal systems. This would enhance the understanding of the gaps in the field and, hence, provide directions for future research and developments.",signatures:"Christian Isalomboto Nkanga, Alain Murhimalika Bapolisi, Nnamdi Ikemefuna Okafor and Rui Werner Maçedo Krause",downloadPdfUrl:"/chapter/pdf-download/66369",previewPdfUrl:"/chapter/pdf-preview/66369",authors:[{id:"284670",title:"Prof.",name:"Rui",surname:"Krause",slug:"rui-krause",fullName:"Rui Krause"},{id:"284672",title:"Mr.",name:"Alain",surname:"Bapolisi",slug:"alain-bapolisi",fullName:"Alain Bapolisi"},{id:"284673",title:"MSc.",name:"Christian",surname:"Nkanga",slug:"christian-nkanga",fullName:"Christian Nkanga"},{id:"284675",title:"Mr.",name:"Okafor",surname:"Nnamdi",slug:"okafor-nnamdi",fullName:"Okafor Nnamdi"}],corrections:null},{id:"67005",title:"Dissipative Particle Dynamics Simulations of Self-Assemblies of Liposomes for Drug Delivery Applications",doi:"10.5772/intechopen.85812",slug:"dissipative-particle-dynamics-simulations-of-self-assemblies-of-liposomes-for-drug-delivery-applicat",totalDownloads:861,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Liposomes are essential components in the development of functional materials for drug delivery; this is mainly due to its ability to self-associate spontaneously and form bilayer vesicles. In these potential applications, knowing the size of self-assembled liposomes is essential for optimal performance; however, this process still has many unanswered questions. Conventional experimental techniques to study self-assemblies of liposome nanoparticles still have a great challenge. Computational simulations emerge as an alternative to understand the role of thermodynamic properties responsible for the self-assembly, particularly when they are unreachable experimentally because of limited time and length resolutions. In this chapter, we present the advantages and disadvantages of dissipative particle dynamic method to explore the functioning of liposome self-assembly in the transport of drugs.",signatures:"Ketzasmin Armando Terrón-Mejía, Inocencio Higuera-Ciapara, Evelin Martínez-Benavidez, Javier Hernández and Roberto López-Rendón",downloadPdfUrl:"/chapter/pdf-download/67005",previewPdfUrl:"/chapter/pdf-preview/67005",authors:[{id:"186353",title:"Dr.",name:"Javier",surname:"Hernandez",slug:"javier-hernandez",fullName:"Javier Hernandez"},{id:"286139",title:"Dr.",name:"Roberto",surname:"López-Rendón",slug:"roberto-lopez-rendon",fullName:"Roberto López-Rendón"},{id:"286252",title:"Dr.",name:"Ketzasmin A.",surname:"Terrón-Mejía",slug:"ketzasmin-a.-terron-mejia",fullName:"Ketzasmin A. Terrón-Mejía"},{id:"286253",title:"Dr.",name:"Inocencio",surname:"Higuera-Ciapara",slug:"inocencio-higuera-ciapara",fullName:"Inocencio Higuera-Ciapara"},{id:"286254",title:"MSc.",name:"Evelin",surname:"Martínez-Benavidez",slug:"evelin-martinez-benavidez",fullName:"Evelin Martínez-Benavidez"}],corrections:null},{id:"66325",title:"Pharmaceutical Development of Liposomes Using the QbD Approach",doi:"10.5772/intechopen.85374",slug:"pharmaceutical-development-of-liposomes-using-the-qbd-approach",totalDownloads:1199,totalCrossrefCites:7,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Quality by Design (QbD) is a systematic, risk-based approach to pharmaceutical product and manufacturing development, which uses quality-improving scientific methods upstream in the research, development, and design phases, in order to assure that quality and safety are designed into product at as early stage as possible. This work focuses on the state-of-the-art applications of the QbD principles in the development of liposomes. The QbD approach has recently been proposed as a useful tool to obtain higher-quality liposomal products, as their development is a challenging task, involving intricate formulation and manufacturing processes. Thus, the current strategies to define the relationship between the critical material attributes or process parameters and product critical quality attributes and to establish the design space are overviewed. 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Although, Candida, a yeast, normally exists in human body; on the skin and in the mouth, throat, gut and vagina, it does not normally cause infection. However, sometimes, yeast proliferation occurs, and Candida spp. cause several infections, such as oral infection affecting the mouth and throat, called oropharyngeal candidiasis (thrush), as well as vulvovaginal, oesophageal, intestinal and invasive candidiasis. Oesophageal candidiasis is a common infection in HIV/AIDS patients. Besides this, the pathogenesis of candidiasis in humans is not completely understood. Infection caused by Candida spp. presents a serious problem because of its drug resistance. Investigation of new and effective active substances against pathogenic Candida spp. and a better understanding of the role of molecular mechanisms involved in the formation of antifungal resistance will help prevent Candida infection among individuals with immunological deficiency and will make the antifungal therapy much more effective and improved. This book is intended to provide a comprehensive overview of the latest information on Candida spp. and Candidiasis.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"d745506200537aa5fd638238c1b01347",bookSignature:"Prof. Tulin Askun and Dr. Juliana Simoni Moraes Tondolo",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/9075.jpg",keywords:"Pathogenicity, Diversity, Genetic Structure, Drug Resistance, Diagnosis, Targeted Therapy, Risk Factors, Antifungal Drug Discovery",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:1,numberOfTotalCitations:1,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 25th 2019",dateEndSecondStepPublish:"February 14th 2020",dateEndThirdStepPublish:"April 14th 2020",dateEndFourthStepPublish:"July 3rd 2020",dateEndFifthStepPublish:"September 1st 2020",remainingDaysToSecondStep:"2 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"89795",title:"Dr.",name:"Tulin",middleName:null,surname:"Askun",slug:"tulin-askun",fullName:"Tulin Askun",profilePictureURL:"https://mts.intechopen.com/storage/users/89795/images/system/89795.png",biography:"Prof. Dr. Tulin Askun is working at the Balikesir University (Turkey), Faculty of Sciences and Arts, Department of Biology, as the Head of Molecular Biology Department. She received both her master's degree in 1996 and her PhD in 2002 from the Balikesir University. In 2012, she received a Project Incentive Award in Basic Sciences from the same institution. 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A WSN is a collection of wireless devices that are typically small, battery-powered, and self-contained (also known as nodes). These devices include on-board computers, communication, and sensing capabilities, enabling them to monitor and transfer data on physical or environmental factors like temperature, sound, and pressure through a unidirectional or bidirectional network. The nodes are made up of a low-power CPU with limited processing, a memory device with limited storage capacity, a radio transceiver with low-power internal/external antenna, a low-data rate and limited range, sensors (scalar, cameras, microphones), and a power supply (batteries and solar cells). In most cases, each device is powered by a battery. Examining each of these gadgets individually may seem to be pointless.
WSNs play an important role in military applications. The increasing deployment of WSNs drives sensor network research. WSNs, on the other hand, maybe used for environmental monitoring, habitat monitoring, classroom/home monitoring, structural monitoring, and health monitoring, among other things. Based on its characteristics, each application has its own design concept and execution to meet its own demands. The qualities of WSN, together with technology improvements, give the greatest benefits to healthcare. A sensor network designed to identify human health indicators is known as a body sensor network (BSN). Because BSN nodes are directly attached to the human body, considerable vigilance is required. For many days, several healthcare applications need the BSN to collect patient data indefinitely without user intervention. Such applications must take into consideration the energy constraints of sensor networks [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15].
The challenges of WBS networks healthcare is a need for everyone’s quality of life in today’s environment. The population of developed countries is growing at a pace that is proportional to the government’s budget. Healthcare systems will face challenges as a result of this. One of the most difficult challenges is making healthcare more accessible to elderly people who live alone. In general, health monitoring is done on a check-in basis, with the patient remembering their symptoms; the doctor performs tests and develops a diagnosis, then monitors the patient’s progress throughout therapy. Wireless sensor network applications in healthcare provide in-home assistance, smart nursing homes, clinical trials, and research advancement. Let’s take a look at some of the challenges and basic features of BSNs before we get into the medical uses of this technology. In healthcare applications, low power, limited computing, security and interference, material restrictions, resilience, continuous operation, and regulatory requirements with elderly people are all issues.
Modern modelling approaches such as fuzzy logic (FL) and artificial neural networks (ANN) are frequently employed in hydrological modelling for a number of applications. The main benefit of these techniques is that they are not constrained by restrictive assumptions such as linearity, normality, or homoscedasticity and that they provide promising and acceptable alternatives to classical stochastic hydrological modelling in time series analysis, such as the auto regressive moving average exogenous (ARMAX) model (autoregressive moving average with exogenous inputs). When applied to hydrological systems, however, traditional stochastic models have many drawbacks, the most notable of which are short-time dependence and the normality assumption, as previously mentioned. Hydrological processes are well recognised for defying these assumptions. ANNs have been recognised as a tool for modelling difficult nonlinear systems and are widely used for hydrological prediction. Their applications range from forecasting hourly and daily river stages to further FL modelling applications in: rainfall-runoff groundwater; and time series modelling [6, 7, 8, 9, 10]. Fuzzy neural networks (FNN) are a unique approach for river flow prediction that blends FL and ANNs.
Because they can estimate any continuous function to any degree of accuracy, the Mamdani and tidal sequence (TS) systems are referred to as universal approximators. The smaller the error tolerance, the more fuzzy rules are necessary. In practise, fuzzy models can always yield nonlinear modelling solutions when the required number of fuzzy sets and rules are provided. In comparison to the TS approximator, the Mamdani approximator has the benefit of being able to use both numerical and verbal data produced from human knowledge and experience.
When nontrapezoidal/nontriangular input fuzzy sets are used, TS fuzzy systems may be more cost-effective than Mamdani fuzzy systems in terms of input fuzzy sets and fuzzy rules. They discovered that TS and Mamdani fuzzy systems have comparable minimal system configurations when trapezoidal or triangular input fuzzy sets are used. The performance of Mamdani (linguistic) and TS (clustering-based) fuzzy models was examined in the spatial interpolation of mechanical features of rocks. In terms of prediction performance, the clustering-based TS fuzzy modelling technique beats the Mamdani model, according to their results. The main purpose of this study is to develop a hybrid model for streamflow forecasting that incorporates both a genetic algorithm and fuzzy logic. Genetic algorithms and neural networks (NNs) were used to train the Mamdani and Takagi-Sugeno fuzzy logic modelling systems, respectively. According to the comparison, the Mamdani approach beats standard methods in terms of avoiding restrictive assumptions, insight into the modelling structure, and modelling accuracy.
Health is always a major concern as the human race improves in terms of technology. The current coronavirus outbreak, which has hurt China’s economy to some extent, exemplifies how healthcare has become more vital. In areas where the pandemic has spread, it is always preferable to monitor these people using remote health monitoring equipment. As a consequence, the current solution is a health monitoring system based on the IoT. Remote patient monitoring provides for patient monitoring outside of typical clinical settings (for example, at home), increasing accessibility to human services offices while cutting expenses. This project’s primary purpose is to design and build a smart patient-health monitoring system that uses sensors to monitor patient health and the internet to alert loved ones if there are any issues. The purpose of developing monitoring systems is to reduce healthcare costs by reducing the number of needed inspections. In an IOT-based framework, different consumers may be able to see sensitive aspects of the patient’s blooming. Because the information should be double-checked by visiting a website or URL, this is the case. In GSM-based patient observation, the rising parameters are communicated utilising GSM through SMS techniques.
In most rural areas, the medical facility would not be within walking distance of the residents. As a consequence, the majority of people must attend doctor’s visits, stay in hospitals, and undergo diagnostic testing procedures. Each of our bodies uses temperature and pulse recognition to determine our overall health. The sensors are linked to a microcontroller that monitors the state and, as a result, is interfaced to an liquid crystal display (LCD) as well as a remote connection that may send alarms. If the framework detects any unusual changes in heart rate or body temperature, it warns the client through IoT and also shows subtle features of the patient’s pulse and temperature on the web in real-time. An IoT-based tolerant wellness monitoring framework efficiently leverages the web to monitor quiet wellbeing metrics and save time in this manner. There is a significant ability to disregard any form of minor health concern, as shown by changes in important components such as body temperature, pulse rate, and so on in the early stages.
When a person’s health condition has developed to the point that his or her life is in peril, they seek medical assistance, perhaps wasting money. This is crucial to consider, especially if an epidemic spreads to a place where doctors are unavailable. Giving patients a smart sensor that can be monitored from afar to avoid the spread of sickness would be a realistic solution that might save many lives. Sensors monitor physiological signs, which are transformed into electrical impulses when a patient enters the healing centre. The basic electrical flag is then updated to an advanced flag (computerised data), which is then stored in RFID. To transfer computerised data to a local server, the Zigbee Protocol is employed. For this framework, Zigbee is a good choice. In this location, there are the most cell hubs. It’s better for gadgets that are smaller and use less energy. A nearby server sends information to the therapeutic server through WLAN.
When the data is transmitted to the therapeutic server, it checks to see whether the patient already has a medical record, then adds the new information to that record and sends it to the specialist. If the patient has not had any prior treatment records, the server creates a new ID and stores the data in its database. The IoT is becoming more widely recognised as a feasible solution for distant value tracking, notably in the field of health monitoring. It permits the secure cloud storage of individual health parameter data, the decrease of hospital visits for routine checks, and, most critically, the remote monitoring and diagnosis of sickness by any doctor. In this research, an IoT-based health monitoring system was developed. Body temperature, pulse rate, and room humidity and temperature were all measured by sensors and shown on an LCD. The sensor data is then wirelessly sent to a medical server. These data are then delivered to a smartphone with an IoT platform that belongs to an authorised person. Based on the findings, the doctor diagnoses the condition and the patient’s current state of health.
The advantages of AI have been extensively researched in the medical literature. Using complicated algorithms, AI can ‘learn’ characteristics from a large quantity of healthcare data and then apply the results to clinical practise. It might potentially include learning and self-correcting capabilities to improve accuracy as input changes. AI systems that give up-to-date medical information from journals, textbooks, and clinical practises may support physicians in providing proper patient care. In addition, an AI system might help to reduce diagnostic and therapeutic errors, which are inevitable in human clinical practise. Furthermore, an AI system extracts important data from a large patient population to assist in the generation of real-time health risk warnings and prediction findings [11, 12, 13, 14, 15].
In this chapter, we look at the current level of AI in healthcare and predict its future. First, we will go over four crucial factors from a medical researcher’s perspective: (1) Justifications for AI use in healthcare, and (2) The sorts of data that AI systems have examined AI devices may be classified into two classes, according to the previous description. The first category includes machine learning (ML) approaches that analyse structured data such as imaging, genomics, and EP data. ML algorithms are used in medical applications to cluster people’ traits or forecast the probability of sickness consequences. The second category includes natural language processing (NLP) tools, which extract information from unstructured data such as clinical notes and medical journals to supplement and enrich organised medical data. Texts are converted into machine-readable structured data, which may then be analysed using ML algorithms.
Lung- and heart-related ailments are at the top of the list of health-related problems/complications. Wireless technology, which is a relatively new concept, may be used to track one’s health. Wireless health monitoring systems make use of wearable sensors, portable remote health systems, wireless communications, and expert systems, among other technologies. Life is valuable, even a single life is valuable, but people are dying due to the lack of health facilities, sickness awareness, and sufficient access to healthcare systems. In all conditions, the IoT assists in the identification of diseases and the treatment of patients. In IoT healthcare systems, there are wireless systems in which different applications and sensors are linked to patients, information is gathered, and the information is communicated to a doctor or specialist through an expert system. Medical devices for the Internet of Things (MD-IoT) are connected to the Internet and use sensors, actuators, and other communication devices to monitor patient health. The expert system uses these devices to transfer patient data and information to a secure cloud-based platform, where it is stored and analysed.
Telemedicine is the practise of caring for a clinician and a patient while they are not physically present with each other. ‘The delivery of healthcare services at a distance’ is how telemedicine is defined. Telemedicine provides a variety of benefits, but it also has many disadvantages. Providers, payers, and politicians all recognise the difficulty of navigating some grey zones. While the sector will rapidly develop over the next decade, it will also provide practical and technological challenges. IoT is the most trustworthy and cost-effective alternative in certain circumstances, and the connection between different devices and interactive communication systems also need further formal examination. By communicating information to healthcare teams such as doctors, nurses, and specialists, IoT (Internet of Things) and mobile technologies make it easier to monitor a patient’s health. Professionals would benefit from using the store and forward method to save and collect patient data that could be accessed at any time.
A smart healthcare system is a piece of technology that enables patients to be treated while also improving their overall quality of life. The smart health concept incorporates the e-health concept, which emphasises a number of technologies such as electronic record management, smart home services, and intelligent and medically connected items. Sensors, smart devices, and expert systems all help to create a smart healthcare system. Healthcare facilities are a big concern in today’s globe, especially in developing countries where rural areas lack access to high-quality hospitals and medical experts. Artificial intelligence has benefited health in the same way it has benefited other aspects of life. The IoT is expanding its capabilities in many areas, including smart cities and smart healthcare. The IoT is now being used in healthcare for remote monitoring and real-time health systems. Controlling and preventing catastrophic events, such as the one that happened in 2020 when the coronavirus disease (COVID-19) ravaged the world, maybe done via IoT technologies without imposing severe restrictions on people and enterprises. COVID-19, unlike SARS in 2003, causes respiratory symptoms and seems to be more contagious. One way to restrict viral transmission until a vaccine is developed is to keep a close eye on physical (or social) distance. Improved surveillance, healthcare, and transportation networks will make it less probable for contagious diseases to spread. An IoT system combined with artificial intelligence (AI) may give the following advantages when considering a pandemic: (1) utilising surveillance and image recognition technologies to enhance public security, (2) using drones for supply, transportation, or disinfection, and (3) leveraging AI-powered apps and platforms to monitor and limit people’s access to public places.
In healthcare, an IoT system is often made up of a number of sensors that are all connected to a computer and allow real-time monitoring of the environment or patients. AI-assisted sensors might be employed in the case of a pandemic to help predict whether or not people are sick based on symptoms like body temperature, coughing patterns, and blood oxygen levels. The ability to monitor people’s locations is another useful function. During an outbreak of severe disease, tracking the distance between people may provide vital information. Using technologies like Bluetooth, we can get a good estimate of how much distance people maintain when walking in public places. This information might be used to target people who are not physically separated by a specified distance, such as 2 m, to stop the virus from spreading further. To prevent the abuse of personal information, security and data management must be addressed throughout the development of such platforms. Following a pandemic, governments may try to use these platforms and data for long-term monitoring to control and monitor people’s behaviour.
One of the problems with traditional medical diagnosis is its inaccuracy and imprecision, which has resulted in the deaths of thousands of people. The development of various algorithms, models, and technologies to ensure accuracy and precision has considerably reduced the number of people who die every day in hospitals, and fuzzy logic, a branch of artificial intelligence, is one of these technologies. Medical diagnostic processes are carried out with the use of computer-assisted technologies, which are growing more common by the day. These systems are based on AI and are designed to diagnose as well as recommend treatments based on symptoms. Many decision support systems (DSSs) have been developed in the medical field, such as Aaphelp, Internist I, Mycin, Emycin, Casnet/Glaucoma, Pip, Dxplain, Quick Medical Reference, Isabel, Refiner Series System, and PMA, to assist medical practitioners in their decisions for diagnosis and treatment of various diseases.
The medical diagnostic System (MDS) is used to diagnose various ailments in an expert system like this. Fuzzy logic was chosen as the AI tool in the recommended system since it is one of the most efficient qualitative computational approaches. Fuzzy logic has been proved to be one of the most effective techniques to offer clarity to the medical field. Medical applications include CADIAG, MILORD, DOCTORMOON, TxDENT, MedFrame/CADIAG-IV, FuzzyTempToxopert, and MDSS, to name a few.
Control systems, household appliances, decision-making systems, and the medical and automotive industries all use fuzzy logic-based automated systems. Some of the concepts used in fuzzy logic include fuzzification, defuzzification, membership function, rules, domains, linguistic variables, and so on. While Boolean algebra’s set values are confined to 0 and 1 or False and True, fuzzy logic proposes that there are extra values between 0 and 1 or False and True, referred to as in-between values. To put it another way, on its set of 0 and 1, Boolean logic employs entirely inclusive and exclusive rules, while fuzzy logic employs wholly inclusive, exclusive, and ‘in between values’ rules. Both expert systems and fuzzy logic control systems are designed to tackle difficult and intricate jobs, but a fuzzy logic control system has the benefit of being able to cope with ambiguity. Language standards are employed to enhance decision-making in the face of uncertainty, emulating a human operator. This decision-making power saves time and reduces or eliminates the need for the human element in control models, which was previously required. A closer look into this cluster reveals that similar themes include the use of intelligent data analysis and related domains to anticipate outbreaks, simulate disease transmission, and screen for the virus on a broad scale. Epidemiology is the term used to describe all of this. Modelling and forecasting the spread of COVID-19 using AI and ML methods may help governments, health organizations, corporations, and people manage the pandemic. In this regard, NNs have also played a significant role. To forecast situations, multi-layer feed-forward NNs and convolution neural networks (CNNs) were utilized. Other well-known algorithms for predicting time series data, such as ARIMA (auto-regressive integrated moving average model) and support vector machine (SVM), have been studied. Several of these models have been used to estimate daily infections during various sorts of lockdowns, assisting government decision-making. Public policies have been effectively planned using ML approaches.
In the creation of vaccines, AI and intelligent data analysis have also proven critical. ML and AI are particularly useful for repetitive activities that need large-scale data processing, making them ideal for drug-development. Deep learning has shown to be a very useful technique for predicting the qualities and uses of pharmaceutical compounds that might trigger a body’s immune response to an illness. Because this analytical method often needs long periods of testing and a considerable expense, automating this contact would be quite beneficial. Scientists have developed algorithms that anticipate which immunogenic regions should be included in a vaccine, allowing the immune system to learn and prepare for specific antigens. Antigens already found in pathogens that may be related to antigens for a new infection may also be recognised by AI, speeding up the process even further.
AI is assisting in the development of vaccines by simplifying the comprehension of viral protein structures and assisting clinical professionals in sifting through hundreds of relevant study findings at a faster rate than would be achievable otherwise. The ability to understand the structure of a virus may aid in the creation of effective vaccination.
AI and soft computing (SC) play a crucial role in healthcare medical diagnostics. Doctors nowadays are unable to advance without the help of technological advancement. This digital advancement will be incomplete if AI and SC are not included. AI is a technique for constructing intelligent machines. The SC is a collection of computer algorithms for seeing and learning real-world information, which allows computers to create AI. As a consequence, the computer can perform as well as a person if the philosophy of human labour can be expressed using AI and SC technologies. In the healthcare sector, this technological development is being used for long-term medical diagnosis. AI is defined by Alan Turing, the discipline’s inventor, as ‘the science and engineering of building machines, especially sophisticated computer programmes.’ Artificial intelligence systems are computer programmes that can mimic human cognitive processes.
In the early phases of AI, philosophy, potential, demonstrations, dreams, and imagination all played a part. In response to a variety of conflicting needs, possibilities, and interests, the field of IA developed. In a range of fields, including healthcare, AI combined with analytics (AIA) is becoming increasingly commonly employed. Medicine was one of the most successful applications of analytics, and it is now a prospective AI application sector. As early as the mid-twentieth century, clinical applications were designed and provided to physicians to assist them in their practise. Among the applications are clinical decision support systems, automated surgery, patient monitoring and assistance, healthcare administration, and others. The current methodologies are mostly focused on knowledge discovery via data and ML, ontologies and semantics, and reasoning, as we will see in the next sections. We will look at how AI has advanced in healthcare over the last 5 years in this piece.
Data mining, ontologies, semantic reasoning, and ontology-extended clinical recommendations, clinical decision support systems, smart homes, and medical big data will be the focus of the examination. The multiple artificial intelligence features of our study were not chosen at random. Indeed, we have noticed that they have developed a strong interest in medicine in recent years. Data mining methods are used in learning and prediction, as well as picture and speech processing, and anything involving emotion and sentiment. Because of their ability to reason, as well as its usage as a way of learning, sharing, reuse, and integration, ontologies have gained momentum in medicine. Clinical decision support systems that assist improve the quality of treatment in clinical practise draw on both disciplines. They are also used in smart homes to help those with cognitive impairments with daily tasks. Big data in medicine is becoming increasingly common, and its application in analytics is unavoidable.
Electricity engineers formerly concentrated their efforts on the production and transmission levels, with the distribution system receiving less attention. Engineers have only recently been provided with the tools necessary to cope with the computational burden of distribution systems to undertake realistic modelling and simulation. The majority of primary distribution systems are built up in a radial configuration, with one end providing each load point. The radial type system is the simplest and most often used for effective coordination of their protective systems. Fuzzy set theory has been developed and used in a range of engineering and non-engineering domains where the evaluation of actions and observations is ‘fuzzy’ in the sense that no clear boundaries exist. The fuzzy set theory provides for the inaccurate representation of evaluations and observations, which may then be utilised to describe and solve issues.
The use of fuzzy set theory to distribution system analysis may aid professional judgement and prior knowledge in distribution system planning, design, and operations. Future computer technology will be considerably more advanced than our greatest imaginations, and far more advanced than anything we can envision right now. The IoT is one of the most cutting-edge technologies, with IoT-enabled things all around us. With the help of RFID (radio frequency identification) and sensors, it will create its own world in which everything will be managed and transmitted over the Internet. The devices will create their own environment. The enormous amount of data created will be recorded, analysed, and presented in a timely, seamless, and understandable way. Cloud computing will provide us with virtual infrastructure for visualisation platforms and utility computing, enabling us to integrate device monitoring, storage, client delivery, analytics tools, and visualisation in one place. Cloud computing, which will provide an end-to-end solution, will allow users and businesses to access applications on-demand from anywhere. One of the most important IoT applications is in the field of healthcare. We designed a health monitoring device using current low-cost sensors to monitor and maintain human health parameters such as heart rate, temperature, and air quality. The approach of fuzzy logic was used. In 1965, Lotfi Zadeh presented the concept of fuzzy logic for the first time.
Fuzzy logic is a kind of multivalued logic with truth values ranging from 0 to 1. Fuzzy logic deals with the concept of partial truth, in which the truth value varies from completely false to completely true. The fuzzy logic technique includes fuzzification, inference, and defuzzification. The sensors capture crisp input data, which is then converted via membership functions into a fuzzy input set, linguistic words, and linguistic variables. The rules are used to make inferences. The system will work on the same principles as the IF-THEN system. The membership function is used to convert the fuzzy output to crisp output.
Vital signs are the four most important markers that reveal the condition of the body’s vital functions. These measurements are used to assess a person’s general physical well-being, detect probable diseases, and monitor healing progress. The fuzzy inference system is a computer framework that makes choices based on fuzzy set theory, fuzzy if-then logic, and fuzzy reasoning. Over the last decade, fuzzy set theory has advanced in many directions, with applications in taxonomy, topology, linguistics, automata theory, logic, control theory, game theory, information theory, psychology, pattern recognition, medicine, law, decision analysis, system theory, and information retrieval, to name a few. A fuzzy inference requires three parts: a membership function generation circuit that calculates the goodness of fit between an input value and the membership function of an antecedent part, a minimum value operation circuit that finds an inference result for each rule, and a maximum value operation circuit that integrates a plurality of inference results. When these components are combined into a system, the system can do inference. Each externally supplied input value, this membership function generating circuit creates one membership function value. The decision-making logic of the fuzzy inference machine is crucial, and it may be the system’s most adaptive component. The fuzzification interface corresponds to our sensory organs (e.g., eye, ear), the de-fuzzification interface to our action organs (e.g., arms, feet, etc.), the fuzzy rule base to our memory, and the fuzzy inference machine to our thought process when a fuzzy system is compared to a human controller. It is called a fuzzy expert system when an expert system uses fuzzy data to reason. It is important to know what makes up a fuzzy expert system. The fuzzy expert system consists of a fuzzy knowledge base (based on fuzzy rules), an interference engine, a working memory subsystem, an explanation subsystem, natural language interference, and knowledge acquisition.
The number of individuals visiting hospitals has grown in recent decades as a result of population expansion and changing lifestyles throughout the world. As a result, the medicare healthcare system is overburdened. On the other hand, for the old, crippled, underprivileged, or those who live far away, visiting the hospital is quite tough. As a consequence, their health may worsen to the point where they die. The Internet has now become a necessary component of our daily life. Education, finance, business, industry, entertainment, social networking, retail, and e-commerce are just a few of the uses of the internet. The IoT is the web’s next big thing (IoT). As a consequence, remote healthcare solutions were created to meet the medicare health system’s above-mentioned difficult challenges. The patient’s vital signs are monitored by electronic sensors and communicated to the hospital server through the Internet, allowing the doctor to examine, diagnose, and prescribe the required medicine to treat the patient without the patient needing to visit the hospital.
Though neither of these quotes is quite true, they lead this introduction because those who are working to heal broken brains and stop the suicide epidemic are closer to winning than when they started. There are no guarantees that collective successes will overcome medical resistance to accepting the obvious: what “they” are doing does not work to heal brain wounds, and “they” ignore and denigrate a safe and effective treatment that does. Yet those trying to get urgent help to suicidal brain wounded service members see victory on the near horizon for the varieties of truths told in the research and worldwide clinical medicine. As with many advances, an anecdote helps elucidate the main point: changing minds and medicine, even with science, data and facts, is not easy work.
Two renegade Australian MDs, Barry Marshall and J. Robin Warren, in
As you read these pages, we expect that you will be whipsawed by the truths exposed as authors and readers wonder about the answer to the Obvious Question:
On August 30, 2002, Medicare announced its intention to issue a national coverage determination (NCD) for Hyperbaric Oxygen Therapy (HBOT) in the treatment of diabetic wounds of the lower extremities. The arguments that led to that determination [3] established that oxygen under pressure was safe and effective for this fourteenth indication, or disease state.
The evolution in thinking and the subsequent research was enabled by the 1999 refinement and restatement of the drug definition of HBOT as the use of greater than atmospheric pressure oxygen as a drug to treat basic pathophysiologic processes and their diseases [4]. The UHMS defines hyperbaric oxygen (HBO2) as an intervention in which an individual breathes near 100% oxygen intermittently while inside a hyperbaric chamber that is pressurized to greater than sea level pressure (1 atmosphere absolute, or ATA) [5]. With that definition the totality of on-label indications could be understood as cohesive sets of diagnoses connected by HBOT effects on the acute and/or chronic underlying pathophysiology common to the diseases.
Doctors noticed that the definition necessarily could be applied to the use of HBOT for additional diseases that shared this pathology. Of the 14/15 indications accepted by the FDA/CMS, at least five are non-healing wounds and therefore closely related to brain wounding from blast, falls, impact, stroke, Improvised explosive devices, and concussion. Those indications are: Crush injury, compartment syndrome, and other acute traumatic ischemias; Arterial Insufficiency, entailing enhancement of healing in selected problem wounds (includes uses like Diabetic Foot Wounds, Hypoxic Wounds); Radiation tissue damage (soft tissue and bony necrosis); Skin grafts and flaps (compromised); and Air or gas embolism (resulting from rapid decompression and blast injury [6].)
The accurate drug definition of HBOT, and its implications for the findings and data in research into traumatic brain injury, is used in this paper to argue for HBOT safety and effectiveness in the treatment of Traumatic Brain Injury. The argument is constructed by identifying the underlying pathophysiology in traumatic brain injury. Evidence for the beneficial effects of HBOT on TBI is presented. Benefits to patients with TBI is discussed. Evidence for HBOT for TBI risk/benefit and cost/are discussed. The conclusion is simple: coverage of HBOT for TBI.
Research over the last two decades has revealed the complex microcosms of multiple pathophysiological processes resulting from insults to the brain, including traumatic brain injury [7]. The three essential components determining the outcome of head injuries are brain blood flow; the pressure in the skull leading to swelling; and hypoxia, the lack of oxygen [8].
According to the Centers for Disease Control and Prevention (CDC), “traumatic brain injury (TBI) is caused by a bump, blow or jolt to the head or a penetrating head injury that disrupts the normal function of the brain.” TBI severity ranges from “mild,” i.e., a brief change in mental status or consciousness to “severe,” i.e., an extended period of unconsciousness or amnesia after the injury [9]. The CDC keeps current statistics on TBI death and disability.
Traumatic brain injury (TBI) is a major cause of death and disability in the United States. Those who survive a TBI can face effects that last a few days, or the rest of their lives. Among TBI-related ED visits and hospitalizations in 2014, statistics notable for the CDC include:
Hospitalization rates were highest among persons 75 years of age and older
The highest rates of ED visits included persons 75 years of age and older
For adults 55 years of age and older, falls were the leading cause of hospitalizations and ED visits
Among TBI-related deaths in 2014, rates were highest for persons 75 years of age and older
In 2014, an average of 155 people in the United States died each day from injuries that include a TBI
Between 2001 and 2010, the estimated average annual numbers of TBI in the US equaled: TBI contributed to the deaths of 56,800 people; 282,000 hospitalizations; and 2.5 M ER visits.
Accidental traumatic brain injuries contributed to more deaths than suicides and homicides together [10].
Approximately 5.3 M people in the US live with a permanent TBI [11]
The lifetime economic cost of TBI, including direct and indirect medical costs, was estimated to be approximately $76.5 billion (in 2010 dollars) [12].
Current estimates put the yearly costs of TBI among veterans at $48 billion [13].
UCLA researchers, citing animal and human studies, speak of “a neurometabolic cascade of events that involves bioenergetic challenges, cytoskeletal and axonal alterations, impairments in neurotransmission and vulnerability to delayed cell death and chronic dysfunction.. .. linking the neurometabolic cascade to clinical characteristics as well as on new connections being made between acute post-concussion pathophysiology, long-term biological changes and chronic sequelae.” [14] Further: “The etiology of postconcussive syndrome is debated, but may be caused by diffuse axonal injury or persistent metabolic alterations resulting in neuronal dysfunction and develops in 38–80% of patients with TBI….” [15].
Advanced neuroimaging reveals the basic neurobiology of concussion/mild TBI in animal models, which is increasingly corroborated in human studies. These images of the brain with such techniques as diffusion tensor imaging (DTI) validate the wounding from the brain injury.
Since HBOT has been studied as a science for over 84 years [16], a wealth of evidence exists - with or without brain imaging or functional imaging such as SPECT scans - that points to the wounding of the brain as an underlying cause of TBI and, in many cases, the cooccurrence of Post-traumatic stress disorder (PTSD). Controversy continues to wage over proper diagnoses of TBI and PTSD. The author is aware for over a decade of clinical medicine and the accumulation of “anecdotal evidence” in over 7500 successful uses of HBOT to help treat and heal TBI, that those combat veterans presenting with “PTSD only” diagnoses from the VA are overwhelmingly afflicted with undiagnosed TBI. Researchers have not yet fully understood how TBI commonly affects the neurological and clinical presentation of PTSD [17]. Despite this high prevalence, the pathogenesis of TBI, PTSD and TBI/PTSD remains largely unknown, hindering prevention and treatment efforts [18].
No matter how acquired, TBI in a veteran or a civilian, is an injury to the brain tissue. Damage is physiological, behavioral, and emotional. Symptoms can include altered consciousness; headaches; structural damage to brain matter and blood vessels and nerves; loss of neurological function that can lead to loss of motor, sensory, coordination, balance, vision, hearing and other abilities; inability to multi-task, slowed reaction time, decreased attention and concentration, inability to think fast; and frequent incapacity to work, sleep, relax, think or discern what is normal. When wounded, the brain, like all body organs, responds with the inflammatory process which proceeds to form scars, scar tissue, and chronic wounds. When the brain injury is compounded by post traumatic stress disorder (PTSD) the victim is subjected to hyperarousal, avoidance behaviors, trauma re-experiencing, increased mental vigilance, difficulty falling asleep, nightmares, constant anxiety resulting from progressive sleep deprivation and elevation of injurious stress hormones. Behaviors and emotions are magnified, intensifying the patient’s negative responses: relationship problems, domestic violence, substance abuse, depression, criminal activity, unemployment, incarceration, homelessness, and too frequently suicide. Where the degenerative cycle can be arrested with drugs or psychological interventions, the result may be a lifetime of degraded quality of life on welfare – not only for the patient but typically for the caregiver as well.
In 2016, researchers at the Uniformed Services University of the Health Sciences in Bethesda, Md., found evidence of tissue damage caused by blasts alone, not by concussions or other injuries [19]. According to the New York Times, this could be the medical explanation for shell shock and the sequalae of psychological problems called PTSD [20]. The implications are clear: IEDs, breeching, enemy and/or friendly fire from personal weapons can lead directly to physical brain damage and the accompanying effects, many of which are diagnosed as “only PTSD.”
Not to be overlooked are the complex interactions among brain injury, trauma, and physical/emotional/behavior/mental health. Psychiatrist Bessel van der Kolk, in The
Several studies have looked at this downward cycle in untreated brain injuries [22] and noted a correspondence between the symptoms resulting from that brain injury and the HBOT Mechanisms of Action that work to arrest and heal the traumatic brain injury.
Medical studies have shown that Hyperbaric Oxygen Therapy is medicine’s best way to provide oxygen to all parts of the body in the shortest period of time. Among many effects, HBOT has been shown to be effective in:
Reducing local swelling (edema) and reperfusion injury
Promoting wound healing
Improving and repairing injury, by increasing oxygen delivery to damaged tissues
Improving infection control
Releasing nitric oxide with migration to point of injury
Increasing the production of collagen
Releasing stem cells with migration to area of injury
Improving blood flow to the affected area of the brain
Restarting stunned cellular metabolism and stunned mitochondria
Generating blood vessel growth (angiogenesis)
Activating stem cells 8x normal to repair neural pathways (neurogenesis)
Decreasing markers of inflammation in the body and brain [23]
While it is uncommon to hear HBOT talked about in terms of healing wounds to the brain, the facts are now obvious: a major organ of the body is damaged. “Treatments” in the DoD and Veterans Administration for a brain-wounded population of at least 414,000 post-9/11 veterans typically resolve to rest and “a mix of cognitive, physical, speech, and occupational therapy, along with medication to control specific symptoms such as headaches or anxiety.” [24] Virtually the last time TBI is referred to as a wound is when speaking of “the Invisible Wounds of War.”
Brain wound healing demands that the body grow new tissue: blood vessels, connective tissue, new brain tissue. Cells have to grow and divide to form new tissue, necessitating stimulation of cells to divide and multiply. DNA must be stimulated [25]. By 2008 DNA analysts found that a single hyperbaric treatment turns on as many as 8101 genes in the 24 hours following HBOT treatment [26]. In short, “the turned-on genes are those genes that code for growth and repair hormones and the anti-inflammatory genes.” [27] As already noted, HBOT is already approved for several on-label indications collectively similar as wound healing. It is worth noting that HBOT chambers are present in 1158 of a total of 3342 hospitals in the US [28]. Those chambers are primarily used for Wound Healing. For a variety of reasons, those chambers are not put to use on off-label uses of HBOT. Nevertheless, the bulk of science on animal and human patients with TBI has been collected in both hospital-based and private clinics.
Dr. Paul Harch prepared voluminous evidence on HBOT for wound healing in his arguments for recognition of DFW in 2002 [29]. More specific to TBI, Dr. Philip James, in “Head Injuries – the Curse of Life in the Fast Lane,” [30] traces the development of HBOT-for-TBI research as far back as 1972 [31]. The study found that tissue oxygen levels that fight hypoxia rise with the increase in either the oxygen concentration or pressure: hyperbaric oxygenation. James writes that “
Of no small importance is groundbreaking research from Washington State University. Researchers found that HBOT can halve the pain and symptoms of opiate withdrawal/detox [37].
And in current investigations of the use of HBOT to arrest and reverse the effects of COVID-19, preliminary evidence from China [38] (five cases) strongly suggests that based on the immutable science of HBOT and recent clinical application to deteriorating severely hypoxemic COVID-19 pneumonia patients, HBOT has significant potential to impact the COVID-19 pandemic. Fifty-eight patients as of this writing have been positively affected. Further, clinicians in at least five independent studies in the US using HBOT are raising the PO2 levels in patients in ICUs to the point where they avoid being put on ventilators and, in many cases, are being sent home after as few as five treatments [39].
A review of the scientific evidence produced in both animal and human HBOT trials over the past twenty years demonstrates conclusively that Hyperbaric Oxygenation of TBI is safe and effective [40]. As early as 1977, Holbach and Wasserman demonstrated that HBOT at 1.5ata puts the most oxygen into the brains of chronic stroke patients [41]. The overriding principle of wound healing, of course, is that the wound must have energy and oxygen to heal. Hypoxia is the most pervasive result of brain insults of all kinds, occasioned by inflammation that leads to reduced oxygen delivery to all body organs.
Following a Consensus Conference in 2008, at which it was declared that HBOT was safe [42], DoD/Army/VA researchers commenced a series of studies to discern whether HBOT was effective in treating TBI. Those studies over nearly eight years consumed over $126Million. Other studies in the private sector costing orders of magnitude fewer dollars were also conducted. To date, there have been at least seventeen peer-reviewed studies that have produced data and findings [43].
U.S. and Israelis clinical trials have provided well-structured, controlled studies demonstrating HBOT medicinal properties in mild TBI and persistent post-concussive symptoms [44]. Positive symptom scores for TBI and PTSD symptom scores for the two government-sponsored studies [45], the Army-sponsored study of Miller et al. [46], a civilian-sponsored study of Harch et al. [47], and an Israeli civilian study [48] show statistically significant improvements over baseline after HBOT treatments.
The studies involved patients with TBI who also suffered from Persistent Post-Concussive Syndrome (PPCS) for at least two years. It was highly unlikely that spontaneous recovery would occur. Five studies provide useful cross-study comparable measures. The U.S. studies used the Immediate Post-Concussion Assessment, Cognitive Testing, Rivermead Post-Concussion Questionnaire, and PTSD Checklist–Military (PCL-M) as the primary and secondary endpoint measures. Even though the Army/VA/DoD sponsored studies claim to be “sham-controlled,” they are really dosing and-pressure-varying trials.
Clinical improvements in the studies were significant and consistent. Looking at dose response profiles shows that lower oxygen levels (100% O2) and lower pressures (2.0 ATA) are probably better for PTST/mTBI and PPCS symptom recovery.
Government-sponsored study authors assumed incorrectly that their control groups received inactive treatment. Yet they write; “We recognize that a sham is not inert, and we cannot completely discount the physiological effects of minimal increases in nitrogen or oxygen from pressurized room air. However, we believe it is biologically implausible that air at 1.2 ATA (equivalent to 2 m of seawater pressure) has a beneficial effect on healing the damaged brain remotely after mTBI [49]. (It is worth noting that the comment bears on relationship to the established science about the medicinal effects of low levels of either oxygen or pressure.) [50] Positive improvements from pretreatment (baseline) measures are observed in all the DoD/VA/Army and civilian studies. The measured responses to both HBO and HBA treatment groups are therapeutic, but a minimal effective dose of O2 at 1ata pressure has not been established in the hyperbaric medical literature. Thus, the use of a sham is problematic and confounding for study interpretation.
Deng and his team in a metanalysis evaluated nine studies comparing the efficacy between hyperbaric oxygen treatment and controls in traumatic brain injury patients [51]. “Brain metabolism, cognitive function, and outcome were taken into consideration. Results showed that HBO treatment significantly improved the Glasgow outcome scale (GOS) score and reduced overall mortality in patients with severe TBI compared with controls. In patients with mild TBI, HBO showed function alleviating the cognitive disorder after trauma, including memory, executive function, attention, and information processing speed.” In patients with TBI, HBO showed significant improvement of Glasgow outcome scale score and reduction of overall mortality while NBO may play a favorable role in improving brain metabolism.
For over four years, clinical and “evidence-based” medicine continue to show that HBOT is safe and effective in treating brain injuries. Objective analysis of the data from all the pivotal RCTs and crossover studies show in over 700 patients that positive improvements result from HBOT treatment protocols. And objective analyses of the studies and data reinforce the findings and the clinical evidence [52].
Dr. Wolf is a principle co-author of the first Army study. This recent USAF paper reanalyzing the data in the cornerstone DOD/VA/Army study concludes: “This pilot study demonstrated no obvious harm [and] both groups showed improvement in scores and thus a benefit. Subgroup analysis of cognitive changes and PCL-M results regarding PTSD demonstrated a relative risk of improvement…. There is a potential gain and no potential loss. The VA/Clinical Practice Guidelines define a “B evidence rating” as “a recommendation that clinicians provide (the service) to eligible patients. At least fair evidence was found that the intervention improves health outcomes and concludes that benefits outweigh harm …. Hyperbaric oxygen therapy for mild traumatic brain injury and PTSD should be considered a legitimate adjunct therapy if future studies demonstrate similar findings or show comparable improvement to standard-of-care or research-related treatment modalities.” [53] Subsequent studies meet those criteria.
The Journal of Hyperbaric Medicine is the most prestigious journal on Hyperbaric Medicine in the world. In 2012 its editor wrote: “ While we applaud good science, there comes a point.. .. of stagnation as the standard of evidence required for the blessing of organized medicine exceeds reality (where most of us live.… I feel, as do many of my colleagues, that there is sufficient clinical and research evidence to justify the use of [HBOT] as a standard-of-care treatment for [TBI] that should be reimbursed by CMS and Tricare…. I have no doubt that, over the next several years, [HBOT] will be proven beyond a reasonable doubt to be one of the most effective treatments for [TBI]…. There is a preponderance of evidence now to justify the use and funding for the treatment….” [54] Wang et al. concur: “Compelling evidence suggests the advantage of hyperbaric oxygen therapy (HBOT) in traumatic brain injury. …Patients undergoing hyperbaric therapy achieved significant improvement. … with a lower overall mortality, suggesting its utility as a standard intensive care regimen in traumatic brain injury.” [55].
The Samueli Institute wrote of DoD studies: “Results showed that both the HBO and sham procedures were associated with significant improvements in post-concussion symptoms and secondary outcomes, including PTSD (which most participants had), depression, sleep quality, satisfaction with life, and physical, cognitive, and mental health functioning.. .. these results are consistent with 2 other sham-controlled clinical trials among service members and veterans involving a range of HBOT doses. … The most remarkable lesson of this study was the difference in clinical outcomes between the 2 chamber procedures (HBO 1.5 ATA and ‘sham’ air 1.3 ATA) and routine post-concussion care. … These findings reinforce the argument that effective interventions [i.e., the current standard of care practiced by military medicine] do not yet exist within the present structure of care or that routine post-concussion interventions within the [DOD or VHA] may even have iatrogenic effects that contribute to symptom persistence, the equivalent of a negative placebo (nocebo) effect.” [56].
While this research has been going on, the VA has been quietly conducting a controlled “demonstration project” to monitor the effects of HBOT for “PTSD-only” veterans. For nearly three years, first two and now five sites around the US are using HBOT to treat PTSD and TBI patients: Tulsa OK, Travis AFB, Joint Base Sam Houston, Tampa, and Fargo ND. While the numbers are small, the results are extremely positive. 30 out of 30 patients have all shown positive medical improvement [57]. Significantly, numerous of the participants are diagnosed with TBI by the VA or have been found to have undiagnosed TBI. Either way, the overwhelming number of patients have improved significantly. These results are significant for reasons related to previous attempts to treat PTSD. The National Academies, writing in 2014 stated: “DoD and VA are spending substantial time, money, and effort on the management of PTSD in service members and veterans [$9.3Billion+ through 2014] [yet] neither department knows with certainty whether those many programs and services are actually successful in reducing the prevalence of PTSD in service members or veterans and in improving their lives.” [58].
A Summary of the positive findings in the studies sponsored by DoD/VA/Army is instructive. They find that HBOT “offered statistical and in some measures clinically significant improvement over local routine TBI care.” They even note the improvements in all groups when measured against the no-treatment group. Even their “expert” consultants wrote that HBOT heals brain injuries. The Army’s premier researcher, Dr. Scott Miller, despite seeming to be looking for “the final nail in the coffin” of HBOT, says on the Veterans Affairs web site: “People did get better and we can’t ignore those results.” [59].
Expert commentary on the issues surrounding the HBOT “sham” revealed the fundamental flaws in the DoD/VA/Army research [60]. In a sham treatment, the researcher goes through the motions without actually performing the treatment. The intent is to have an inert or medically inactive procedure or substance used to compare results with active substances. A placebo is often used with half the people in a drug trial to help show whether the drug being studied is more effective than an inactive “sugar pill.” The results of each group are compared. [NOTE: Debate continues on whether it is possible, under the circumstances of HBOT treatment, to construct a true sham-controlled study.]
The placebo effect is very difficult, if not impossible, to prove in HBOT studies on patients suffering from PPCS that accompanies TBI. Further studies cannot ignore a placebo, but the overwhelmingly positive effects in so many, and so widely different studies, make the likelihood of a placebo unusual. [NOTE: when physiologic changes, such as both structural and functional increases in brain mass and activity are noted – as they were not in DoD/VA/Army studies, since they refuse to perform such objective science – it is impossible to ascribe the changes to the placebo effect. In numerous of the non-government published peer-reviewed studies on the use of HBOT for TBI, however, such positive transformations have been noted in the treated patients. Objective evidence of changes are shown in peer-reviewed research using such methods as SPECT scans, RightEye, qEEG, etc. Those changes can only be the effect of exposure to HBOT [61].]
A worldwide surge of challenges arose when the DoD/Army/VA studies purported to use a sham in their studies and reported that HBOT “does not work.” [62] International researchers and authorities could read that both the data and the discussion in all the purported randomized controlled studies said virtually the same thing: “Both intervention groups [sham and treated] demonstrated improved outcomes compared with PCS care alone” [63] Dr. Pierre Marois spoke for many: “By definition “sham” is “something false or empty”. Hyperbaric treatments at 1.2 ATA substantially increase the amount of dissolved oxygen in the blood and simultaneously induce cascades of metabolic changes and genes activation. Therefore, the supposedly sham treatment of Miller’s study is not close to being a placebo.” [64].
The clearest example to date that demonstrates that these gas/pressure combinations have a therapeutic effect on brain injury models is the article by Malek et al. [65] They demonstrated that HBO (100% O2) and HBA (21% O2/79% N2) were equivalent in protecting neurons after transient forebrain ischemia in the gerbil using 2.5 ATA. The role of a potential placebo effect was ruled out in this study and demonstrates the activity of HBO and HBA in a neurologic injury model.
The certainty that hyperbaric medicine begins with any increase in oxygen concentration and/or pressure is further substantiated by on-going work at the University of Wisconsin [66]. Animal studies already show a significant increase in mobilized stem progenitor cells and decrease in Inflammatory cytokines when HBOT and HBAT (room-air) are applied at pressures as low as 1.2ata. Together these findings support the likelihood of biologic activity, consubstantial with HBOT, being activated at much lower dose of hyperoxia than previously postulated. Those results, coupled with decades of experiments by the US Navy and US Air Force [67], demonstrate that the Army’s and UHMS’s claims that hyperbaric medicine only occurs at pressures higher than 1.4ata are fallacious. Any increase in oxygen concentration and/or pressure is a medical intervention.
The USAF TBI study used the Agency for Healthcare Quality and Research recommendations for future HBOT research for TBI. One pertinent comment was the following: “Whether placebo-controlled trials are necessary to evaluate HBOT has received a great deal of attention in discussions about HBOT. Participants on all sides of this debate make the assumption that an “evidence-based” approach implies devotion to double-blind, placebo-controlled trials without regard to practical or ethical considerations. This assumption is false. Double-blind, placebo-controlled trials are the “gold standard” for government regulators overseeing the approval of new pharmaceuticals, but not for clinical decision-making or insurance coverage decisions. Evidence-based clinical decisions rely more heavily on comparisons of one treatment to other potentially effective therapies, not to placebos.” [68].
In what will be a ground-breaking analysis released on Veterans’ Day, November 11, 2020, The TreatNOW Coalition, building on the seminal work done in 2011 [69], will update and expand the “true cost of ownership” to the American taxpayer of untreated brain injuries. Most studies attempting to estimate costs typically pay attention to the obvious cost categories – drugs, yearly health care costs, ER visits, hospitalizations, psychiatric care, home health care, long term care, lost wages, and sometimes even the impact on the family. TreatNOW has gone much further in examining the “ripple effect” through the family and into society.
The Study looks at impact on the family in categories such as physical and mental damage to immediate family members, including children and care-givers; social services for children affected by turmoil; and spousal suicides occasioned by violence and abuse. Divorce, homelessness, drug abuse, incarceration, death-by-cop, and the estimated 135 people seemingly affected with every suicide [70].
A major “cost” to society beyond the medical expenditures are the tax implications of taking a brain-wounded citizen out of the work force. In too many cases, that actually equates to two lost incomes and taxes because a care-giver is typically a full-time aide to the wounded.
Brain Injury Facts about veterans are hard to pin down accurately since there are so much missing data. For example, the VA estimates that 70% of veterans are not part of the VA system. The VA also estimates TBIs alone for the period of 2000–2017 is over 414,000. RAND estimates that about one-third of all returning vets reported symptoms of some mental health or cognitive condition. More recent estimates range up to 800,000+ for post-9/11, and an equal number of living veterans from service in the 20th century. Civilian casualties are estimated by the CDC as 2.5 million per year, with more than 5 million American effectively unemployable and unable to perform activities of daily living.
To summarize a much more robust analytical picture: untreated brain injuries cost billions of dollars each year when many of them could be reversed by application of HBOT to help heal the underlying and frequently ignored or misdiagnosed brain injury. It costs somewhere between $40,000 and $60,000 per year for each brain injured patient. HBOT treatment has shown an 85% probability of making a significant contribution to the health and welfare of treated patients, at a cost of approximately $20,000. Thus, for less than 2% of the costs of sustaining the brain wounded on welfare, those brain injuries could be treated. The possibility of returning Quality of life and independence to a significant fraction of those wounded is high.
Should further research be required before HBOT for TBI receives an indication, the Center for Medicare and Medicaid (CMS) issued Guidance for the Public, Industry, and CMS Staff, Coverage with Evidence Development, November 20, 2014 [71]. CMS and AHRQ declared that the principal purpose of the study would be to test whether the item or service (HBOT for TBI) meaningfully improves health outcomes of affected beneficiaries who are represented by the enrolled subjects. Unsurprisingly, the data and the demographics support immediate use of HBOT.
It has been the experience of independent scientists over the last decade that peer-reviewed evidence from around the world attests to the safety and efficacy of HBOT in treating and helping to heal TBI and other neurological disorders. Yet the bulk of research on brain diseases and injury focuses on description and causes rather than treatments. Research into “treatments” is by design focused on treating symptoms. Clinical Practice Guidelines from the VA/DoD, for example, specifically focus on the “management” of concussion/mild traumatic brain injury [72]. Their CPG is a compendium of best practices for dealing with symptoms, not with healing or curing. No mention is made in the document of the wound to the brain, nor to healing that wound. And none of the treatments listed as standard of practice are approved by the FDA for treating TBI [73].
Unsurprisingly, huge sums are being poured into worldwide research, some coordinated, most in a competitive surge to devise better ways to understand the structure, function, aberrations and diseases, and treatments for the brain. The US (the Brain Initiative), Europe (Human Brain Project), Japan (Brain/MINDS Project), China (Brain Project), Israel, Australia and Canada have funded major projects [74]. Groups like One Mind and Paul Allen’s Brain Institute are exploring how the brain works and what causes neurological disorders. While the projects vary slightly in their aims, the thrust is on knowledge rather than clinical medicine and healing. Longer-term goals of course include medicine to the patient. Yet precious little in all the efforts is being done to find immediate-use methods to intervene in areas of wide and profound importance to human mental health.
On a more mundane basis, federal, state, local, public and private efforts continue year-after-year to address in conferences and papers and legislation the perennial, interrelated issues of suicide, mental health, brain injury, addiction, and neurocognitive and neurological decline. It is hardly surprising that the expenditures promise phenomenal rewards for breakthroughs. Meanwhile, billions are expended treating symptoms of underlying brain damage that the science demonstrates is both treatable and potentially reversible, not later, but now.
Wright and Figueroa summarize for the majority of researchers on the use of HBOT to treat and help heal TBI: “There is sufficient evidence for the safety and preliminary efficacy data from clinical studies to support the use of HBOT in mild traumatic brain injury/persistent post concussive syndrome (mTBI/PPCS). The reported positive outcomes and the durability of those outcomes has been demonstrated at 6 months post HBOT treatment. Given the current policy by Tricare and the VA to allow physicians to prescribe drugs or therapies in an off-label manner for mTBI/PPCS management and reimburse for the treatment, it is past time that HBOT be given the same opportunity. This is now an issue of policy modification and reimbursement, not an issue of scientific proof or preliminary clinical efficacy.” [75].
It is time to recognize the worldwide body of data, reduce healthcare costs, improve the lives of millions of brain-wounded and their families, and avoid lifetimes of lost earnings and the social impact of avoidable suffering. HBOT should be endorsed for the treatment of Traumatic Brain Injury. This can be achieved by extending CMS coverage to this diagnosis.
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Contact angle is the main parameter that characterizes the drop shape on the solid surface and is also one of the directly measurable properties of the phase interface. In this chapter, the wettability and its related properties of pristine and modified polymer foils will be described. The wettability depends on surface roughness and chemical composition. Changes of these parameters can adjust the values of contact angle and, therefore, wettability. In the case of pristine polymer materials, their wettability is unsuitable for a wide range of applications (such as tissue engineering, printing, and coating). Polymer surfaces can easily be modified by, e.g., plasma discharge, whereas the bulk properties remain unchanged. This modification leads to oxidation of the treated layer and creation of new chemical groups that mainly contain oxygen. Immediately after plasma treatment, the values of the contact angles of the modified polymer significantly decrease. In the case of a specific polymer, the strongly hydrophilic surface is created and leads to total spreading of the water drop. Wettability is strongly dependent on time from modification.",book:{id:"5319",slug:"wetting-and-wettability",title:"Wetting and Wettability",fullTitle:"Wetting and Wettability"},signatures:"Nikola Slepickova Kasalkova, Petr Slepicka, Zdenka Kolska and\nVaclav Svorcik",authors:[{id:"144929",title:"Prof.",name:"Vaclav",middleName:null,surname:"Svorcik",slug:"vaclav-svorcik",fullName:"Vaclav Svorcik"},{id:"146297",title:"Dr.",name:"Petr",middleName:null,surname:"Slepicka",slug:"petr-slepicka",fullName:"Petr Slepicka"},{id:"147600",title:"Ph.D.",name:"Nikola",middleName:null,surname:"Slepičková Kasálková",slug:"nikola-slepickova-kasalkova",fullName:"Nikola Slepičková Kasálková"},{id:"153983",title:"Dr.",name:"Zdeňka",middleName:null,surname:"Kolská",slug:"zdenka-kolska",fullName:"Zdeňka Kolská"}]},{id:"30975",doi:"10.5772/36619",title:"Solution Properties of κ-Carrageenan and Its Interaction with Other Polysaccharides in Aqueous Media",slug:"solution-properties-of-k-carrageenan-and-its-interaction-with-other-polysaccharides-in-aqueous-media",totalDownloads:7591,totalCrossrefCites:5,totalDimensionsCites:32,abstract:null,book:{id:"1601",slug:"rheology",title:"Rheology",fullTitle:"Rheology"},signatures:"Alberto Tecante and María del Carmen Núñez Santiago",authors:[{id:"109087",title:"Prof.",name:"Alberto",middleName:null,surname:"Tecante",slug:"alberto-tecante",fullName:"Alberto Tecante"},{id:"109098",title:"Dr.",name:"Maria Del Carmen",middleName:null,surname:"Nunez-Santiago",slug:"maria-del-carmen-nunez-santiago",fullName:"Maria Del Carmen Nunez-Santiago"}]},{id:"48822",doi:"10.5772/60808",title:"Wettability of Nanostructured Surfaces",slug:"wettability-of-nanostructured-surfaces",totalDownloads:3128,totalCrossrefCites:11,totalDimensionsCites:32,abstract:"There are many studies in literature concerning contact angle measurements on different materials/substrates. It is documented that textiles can be coated with multifunctional materials in form of thin films or nanoparticles to acquire characteristics that can improve the protection and comfort of the wearer. The capacity of oxide nanostructures to inhibit fungal development and neutralize bacteria is a direct consequence of their wetting behavior [1–6]. Moreover, the radical modification of wetting behavior of nanostructures from hydrophilic to hydrophobic when changing the pulsed laser deposition (PLD) ambient will be thoroughly discussed.",book:{id:"5319",slug:"wetting-and-wettability",title:"Wetting and Wettability",fullTitle:"Wetting and Wettability"},signatures:"L. Duta, A.C. Popescu, I. Zgura, N. Preda and I.N. Mihailescu",authors:[{id:"17636",title:"Prof.",name:"Ion N.",middleName:null,surname:"Mihailescu",slug:"ion-n.-mihailescu",fullName:"Ion N. 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Mineral acids like hydrochloric and sulfuric acids are most widely used in pickling baths to remove the metal oxides formed on the surface. The multidisciplinary aspect of corrosion problems combined with the distributed responsibilities associated with such problems only increase the complexity of the subject. Inhibitors are used in industrial and commercial processes to minimize both the metal loss and acid consumption.",book:{id:"7550",slug:"corrosion-inhibitors",title:"Corrosion Inhibitors",fullTitle:"Corrosion Inhibitors"},signatures:"Geethamani Palanisamy",authors:[{id:"253697",title:"Dr.",name:"Geethamani",middleName:null,surname:"Palanisamy",slug:"geethamani-palanisamy",fullName:"Geethamani Palanisamy"}]}],mostDownloadedChaptersLast30Days:[{id:"48768",title:"TiO2 -Based Surfaces with Special Wettability – From Nature to Biomimetic Application",slug:"tio2-based-surfaces-with-special-wettability-from-nature-to-biomimetic-application",totalDownloads:5010,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"Super-wetting/antiwetting surfaces with extremely high contrast of surface energy and liquid adhesion have attracted a lot of interest in both fundamental research and industry. Various types of special wetting surfaces can be constructed by adjusting the topographical structure and chemical composition. In this chapter, recent advance of the super-wetting/antiwetting surfaces with special solid/liquid adhesion has been reviewed, with a focus on the biomimetic fabrication and applications of TiO2-based surfaces. Special super-wettability examples include lotus-leaf-inspired surfaces with low adhesion, rose-petal-inspired surfaces with high adhesion, spider silk bio-inspired surfaces with directional adhesion, fish-scale-inspired underwater superoleophobic surface, and artificial surfaces with controllable or stimuli-responsive liquid adhesion. In addition, we will review some potential applications related to artificial antiwetting surface with controllable adhesion, e.g., self-cleaning, antifogging/anti-icing, micro-droplet manipulation, fog/water collection, water/oil separation, anti-bioadhesion, micro-template for patterning, and friction reduction. Finally, the difficulty and prospects of this renascent and rapidly developing field are also briefly proposed and discussed.",book:{id:"5319",slug:"wetting-and-wettability",title:"Wetting and Wettability",fullTitle:"Wetting and Wettability"},signatures:"Jian-Ying Huang and Yue-Kun Lai",authors:[{id:"175512",title:"Prof.",name:"Yuekun",middleName:null,surname:"Lai",slug:"yuekun-lai",fullName:"Yuekun Lai"}]},{id:"64392",title:"Corrosion Inhibitors",slug:"corrosion-inhibitors",totalDownloads:3318,totalCrossrefCites:18,totalDimensionsCites:28,abstract:"Corrosion is a natural process driven by energy consideration. Inhibition is a preventive measure against corrosive attack on metallic materials. Corrosion inhibitors have been frequently studied, since they offer simple solution for protection of metals against corrosion in aqueous environment. Mineral acids like hydrochloric and sulfuric acids are most widely used in pickling baths to remove the metal oxides formed on the surface. The multidisciplinary aspect of corrosion problems combined with the distributed responsibilities associated with such problems only increase the complexity of the subject. Inhibitors are used in industrial and commercial processes to minimize both the metal loss and acid consumption.",book:{id:"7550",slug:"corrosion-inhibitors",title:"Corrosion Inhibitors",fullTitle:"Corrosion Inhibitors"},signatures:"Geethamani Palanisamy",authors:[{id:"253697",title:"Dr.",name:"Geethamani",middleName:null,surname:"Palanisamy",slug:"geethamani-palanisamy",fullName:"Geethamani Palanisamy"}]},{id:"68236",title:"The Arrhenius Acid and Base Theory",slug:"the-arrhenius-acid-and-base-theory",totalDownloads:1380,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Swedish Svante Arrhenius, in 1884 proposed the concept of acid and base based on the theory of ionization. According to Arrhenius, the acids are the hydrogen-containing compounds which give H+ ions or protons on dissociation in water and bases are the hydroxide compounds which give OH− ions on dissociation in water. This concept is only applicable to those compounds which dissolved in aqueous solution (or you can say where water is the solvent). It covers many common acids, bases and their chemical reactions, but there are also other compounds that have the characteristics of acids and bases but they do not fit into Arrhenius concept.",book:{id:"10050",slug:"corrosion",title:"Corrosion",fullTitle:"Corrosion"},signatures:"Shikha Munjal and Aakash Singh",authors:[{id:"290524",title:"Ms.",name:"Shikha",middleName:null,surname:"Munjal",slug:"shikha-munjal",fullName:"Shikha Munjal"}]},{id:"71924",title:"Technological Background and Properties of Thin Film Semiconductors",slug:"technological-background-and-properties-of-thin-film-semiconductors",totalDownloads:886,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Especially with the development of nanotechnology and polymer science, interest in research and production of both efficient and lower-cost semiconductor thin film materials is increasing day by day. The use of nano-structured thin films for efficient use of solar cells in production of n-type semiconductor materials is one of the most important sources of energy and new-generation energy. Considering the indicated trends and energy requirements, it has been important to transfer this technology in detail regarding the surface technologies related to the semiconductor materials produced with thin film technologies instead of bulk materials. With this aim, this book chapter “Technological Background and Properties of Thin Film Semiconductors” includes a brief story about semiconductors, band gap theory, thin film applications, and besides traditional thin film processing methods finally a new technology called aerosol deposition technique which allows room temperature processing of several materials for semiconductor applications, respectively. It is thought that it will make important contributions to the relevant field and bring a new perspective and direct scientific research in “process-structure–property-performance” relation.",book:{id:"10061",slug:"21st-century-surface-science-a-handbook",title:"21st Century Surface Science",fullTitle:"21st Century Surface Science - a Handbook"},signatures:"Orkut Sancakoglu",authors:[{id:"177188",title:"Dr.",name:"Orkut",middleName:null,surname:"Sancakoğlu",slug:"orkut-sancakoglu",fullName:"Orkut Sancakoğlu"}]},{id:"60426",title:"Applications of Viscoelastic Fluids Involving Hydrodynamic Stability and Heat Transfer",slug:"applications-of-viscoelastic-fluids-involving-hydrodynamic-stability-and-heat-transfer",totalDownloads:1331,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Rayleigh and Marangoni convection and rheology are linked in the thermal convection of viscoelastic fluids to some recent technological applications. Such technology developments as the ones presented here undoubtedly shall be based on interdisciplinary projects involving not only rheology or fluid mechanics but several other disciplines. Three practical applications which use Rayleigh or Marangoni convection in their working principle are presented along with some technical details. This contribution focus mainly on the physical mechanism and the involved hydrodynamics of some lab and industrial applications. Finally, a short discussion on the role play by the convective mechanisms is given in order to provide integration of the exposed ideas.",book:{id:"6702",slug:"polymer-rheology",title:"Polymer Rheology",fullTitle:"Polymer Rheology"},signatures:"Ildebrando Pérez-Reyes, René Osvaldo Vargas-Aguilar, Samuel\nBernardo Pérez-Vega and Alejandro Sebastián Ortiz-Pérez",authors:[{id:"183938",title:"Dr.",name:"Samuel",middleName:null,surname:"Perez-Vega",slug:"samuel-perez-vega",fullName:"Samuel Perez-Vega"},{id:"186659",title:"Prof.",name:"Ildebrando",middleName:null,surname:"Pérez-Reyes",slug:"ildebrando-perez-reyes",fullName:"Ildebrando Pérez-Reyes"},{id:"242858",title:"Prof.",name:"Rene Osvaldo",middleName:null,surname:"Vargas-Aguilar",slug:"rene-osvaldo-vargas-aguilar",fullName:"Rene Osvaldo Vargas-Aguilar"},{id:"242859",title:"Prof.",name:"Alejandro Sebastian",middleName:null,surname:"Ortiz-Perez",slug:"alejandro-sebastian-ortiz-perez",fullName:"Alejandro Sebastian Ortiz-Perez"}]}],onlineFirstChaptersFilter:{topicId:"160",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"\r\n\tScientists have long researched to understand the environment and man’s place in it. 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