\r\n\tTherefore, the objective of this book is to provide an outlook of the present research on Applied Geomorphology in different parts of the world, highlighting the main challenges mankind faces on this subject. The debate on future perspectives of anthropogenic impacts on the Earth surface and systems, the evolution of concepts on Applied Geomorphology, processes and landforms evaluation and modeling, recurring to recent technologies and methods, geomorphological hazard analysis, as well as strategies for landform conservation and promotion (for non-extractive and destructive activities, e.g. geotourism), are also objectives to pursuit on this book.
",isbn:"978-1-80356-423-4",printIsbn:"978-1-80356-422-7",pdfIsbn:"978-1-80356-424-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"f9f0fe8910dc02818cad71316650d297",bookSignature:"Prof. António Vieira",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11491.jpg",keywords:"Theory, Processes, Methodologies, GIS, Remote Sensing, UAV, Human Impact, Anthropocene, Slope Instability, Climate Change, Geomorphosites, Geotourism",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 25th 2022",dateEndSecondStepPublish:"April 27th 2022",dateEndThirdStepPublish:"June 26th 2022",dateEndFourthStepPublish:"September 14th 2022",dateEndFifthStepPublish:"November 13th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A geographer with a career of more than 20 years devoted mainly to geomorphological research, centered in the topics of granitic geomorphology, soil erosion, and geomorphological heritage, and responsible for Ph.D. and Pos-doc researchers and for research project leadership. He is an assistant professor in the Department of Geography, University of Minho (UM), Portugal, and an integrated member of the Communication and Society Research Centre (CECS), UM.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"103627",title:"Prof.",name:"António",middleName:null,surname:"Vieira",slug:"antonio-vieira",fullName:"António Vieira",profilePictureURL:"https://mts.intechopen.com/storage/users/103627/images/system/103627.png",biography:"Antonio Vieira is a geographer with a Ph.D. in Geography from the University of Coimbra, Portugal (2009). He is an assistant professor in the Department of Geography, University of Minho (UM), Portugal, and an integrated member of the Communication and Society Research Centre (CECS), UM. He is a member of several scientific organizations, including the Portuguese Association of Geomorphologists (Chair from 2017 to 2019) and the Portuguese Association of Risk, Prevention and Security (vice-president since 2015). He is also a member of FuegoRED and coordinator of the FESP International Network. Dr. Vieira’s main research includes granitic geomorphology, geomorphological heritage and changes in land use, GIS and remote sensing, and their application to land use, geomorphological heritage, and soil erosion following forest fires and mitigation measures.",institutionString:"University of Minho",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Minho",institutionURL:null,country:{name:"Portugal"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"10",title:"Earth and Planetary Sciences",slug:"earth-and-planetary-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444318",firstName:"Nika",lastName:"Karamatic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444318/images/20011_n.jpg",email:"nika@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10409",title:"Soil Erosion",subtitle:"Current Challenges and Future Perspectives in a Changing World",isOpenForSubmission:!1,hash:"100d8afa798aacadca65a149a4f902b5",slug:"soil-erosion-current-challenges-and-future-perspectives-in-a-changing-world",bookSignature:"António Vieira and Silvio Carlos Rodrigues",coverURL:"https://cdn.intechopen.com/books/images_new/10409.jpg",editedByType:"Edited by",editors:[{id:"103627",title:"Prof.",name:"António",surname:"Vieira",slug:"antonio-vieira",fullName:"António Vieira"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5962",title:"Estuary",subtitle:null,isOpenForSubmission:!1,hash:"43058846a64b270e9167d478e966161a",slug:"estuary",bookSignature:"William Froneman",coverURL:"https://cdn.intechopen.com/books/images_new/5962.jpg",editedByType:"Edited by",editors:[{id:"109336",title:"Prof.",name:"William",surname:"Froneman",slug:"william-froneman",fullName:"William Froneman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"77202",title:"Surgical Approach to Rib Fractures",doi:"10.5772/intechopen.98594",slug:"surgical-approach-to-rib-fractures",body:'
1. Introduction
The ribs are rigid and flexible structures that make up the chest skeleton and are a set of twelve paired bones. Pain, tenderness, cracking sound with movement in the chest area in cases such as compression, falling, hitting, and beating due to external factors bring to mind the rib fracture. Simple bumps, severe coughing and even sneezing can cause rib fractures in the elderly, where bones are more fragile. It is important to follow up elderly patients with multiple rib fractures in the hospital to prevent complications such as atelectasis and similar complications that may occur in the late period. If the patients are young, uncomplicated rib fractures can be followed up on an outpatient basis. After Blunt trauma rib fractures of incidence is about 30 to 40% [1].
Multiple rib fractures cause severe respiratory problems such as severe pain, dyspnea, flail chest, and atelectasis. Patients need medical or surgical intervention must be made. While the cracks in the ribs caused by traumas are insignificant, rib fractures can lead to intrathoracic organ and vascular injuries. Due to traumas, 4–9. ribs are often affected. 1.-2. fractures in ribs, subclavian vessel and brachial plexus damage, presence of fractures in one or more of the first 3 ribs of the upper thorax, major vascular injuries such as aorta indicate that the trauma is very severe. The fracture point of the ribs is often on the midaxillary line. In fractures in the lower elevations (9th–12th ribs), intraabdominal organ injuries such as liver, spleen and kidney should be investigated. 10–11. ribs fractures are rare because the ribs are more flexible. As the number of rib fractures increases, the risk increases in direct proportion. Complications may vary depending on the localization of rib fractures. Pneumothorax and hemothorax may develop as a result of the sharp end of the broken rib causing lung parenchymal damage, and after tube thoracostomy is applied, rib fractures should be intervened [2].
2. Clinical examination
Pain is the most important symptom indicating rib fracture, and it usually increases with coughing, breathing, and movement. Broken rib ends can be felt with palpation at the time of coughing or deep breathing.
3. Diagnostic methods
3.1 X-ray
It is useful in showing displaced rib fractures, hemothorax and pneumothorax. Almost 50% of rib fractures can be missed on chest radiography. Lateral rib fractures can be hidden by rib lines in the absence of significant separation. Lower rib fractures (10–12th) can be observed on thoracolombar radiographs. Although special radiographs in oblique and bone dose increase the diagnosis rate, it is unnecessary because the treatment will be made according to the clinical findings (Figure 1).
Figure 1.
PA Chest Radiography. Left multiple rib fractures, subcutaneous emphysema.
3.2 Computed tomography (CT)
It is possible to detect rib fractures, soft tissue and vascular injuries that cannot be detected by x-ray (Figure 2).
Figure 2.
Computed tomography (CT). Left displaced rib fractures, subcutaneous emphysema and pneumothorax.
Figure 3.
a–c. Judet plates (toothed plates) and surgical fixation of ribs.
3.3 Magnetic resonance imaging (MR)
It shows ridge circumference, soft tissue and organ damage. It is also effective in detecting thinner rib fractures.
4. Treatment approaches
4.1 Medical treatment
Most rib fractures, especially nondisplaced ones, heal spontaneously within about six weeks. In medical treatments, epidural catheter application, nonsteroidal anti-inflammatories, intravenous narcotic sedatives and transdermal narcotic agents can be used.
4.2 Nerve blocks
If the pain caused by rib fractures is severe and does not pass, intercostal nerve blockage (long-term anesthesia injection) can be applied.
4.3 Surgical fixation
It is an alternative method to prevent pain and complications due to rib fracture. Surgical intervention is the process of stabilizing the chest wall with rib fixations. Especially patients in intensive care, it plays an important role in reducing the duration of mechanical ventilation and the duration of stay in the intensive care unit, the cost of hospitalization, and the prevention of complications such as infection and morbidity [1].
The flail chest is formed by fractures of at least 3 adjacent ribs in at least 2 different places. Close follow-up of these patients and combating pain and secretions are important. If hypoxia develops in the sail chest, endotracheal intubation and a mechanical ventilator are required in the intensive care unit. With open reduction, rib fixation reduces the morbidity of the patient, and the need for mechanical ventilators and pulmonary infections [3, 4].
The indication for fixation of ribs is usually performing thoracotomy for another reason and applying fixation in this session. The durability of the fixation method to be chosen in the fixation application of the patient is also important. Plate application is very difficult, especially in rib fractures that develop in the posterior. A strong fixation should be provided against breathing, cough and the impacts that may come from outside. Nondisplaced rib fracture ends spontaneously heal by merging with callus formation. However, if the union does not occur at the displaced rib fracture ends, it causes serious pain in the patient (Table 1) [4, 5, 6].
Types of plates and properties used in the fixation of rib fractures.
Figure 5.
a and b. U-plates.
Figure 6.
Bio-absorbable plates.
Figure 7.
a and b. Intramedullary plates.
Cho et al. achieved a successful stabilization using the “bone graft and reconstruction plate” in a patient who had previously undergone stabilization with a kirschner wire but no callus occurred [7]. In a series where fixation is applied to the ribs with the help of an absorbable plate, The application helped the patients to leave the ventilator and even if the application was subjective, it was beneficial [8].
Plaque application is more difficult, especially in rib fractures that develop posteriorly. Researchers who found that intramedullary fixation is both easier and safer in these cases also underlined that the rib splint is more advantageous than the kirschner wire [9]. It is also important that the material to be used in stabilizing the rib fractures does not cause problems in later imaging methods (Figure 8).
Figure 8.
Chest Radiograpeouhy. Surgical fixation of right rib fractures.
Balcı et al. preferred titanium plate for this purpose and found that the material did not interfere with the visualization in thoracic CT and MRI taken after the plate application [10].
Today, MRI compatible titanium and nithinol plates are more preferred in rib fracture fixations. Very successful results are obtained in the short and long term follow-up of the patients (Figure 9).
Figure 9.
Use of nithinol plate in rib fractures (Judet plates).
5. Conclusion
Surgical stabilization of rib fractures reduces the possible pulmonary complications of patients. It shortens the duration of hospital stay and the time to return to work, improves the quality of life of the patients by physiologically improving their breathing.
\n',keywords:"Trauma, rib, fracture, surgical fixation, plaque",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77202.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77202.xml",downloadPdfUrl:"/chapter/pdf-download/77202",previewPdfUrl:"/chapter/pdf-preview/77202",totalDownloads:156,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:40,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"May 2nd 2021",dateReviewed:"May 27th 2021",datePrePublished:"July 2nd 2021",datePublished:"February 16th 2022",dateFinished:"June 15th 2021",readingETA:"0",abstract:"Rib fractures due to thorax trauma are one of the issues that mostly concern thoracic surgeons. Treatment for rib fractures is usually conservative. However, in some cases, fractured rib can cause complicated situations and surgical repair is required. Very serious respiratory problems occur in multiple costa fractures. Therefore, many advantages of surgical stabilization of the thorax wall have been reported. Especially shortening mechanical ventilation, decreasing the duration of intensive care unit stay, is important in preventing complications. Operation indications; Persistent pain despite intercostal block, narcotic and nonsteroidal anti-inflammatory analgesics, It was determined upon the presence of leakage from the thorax tube, intrathoracic hematoma and flail chest deformity. Nowadays, nithinol plates and titanium plates are frequently used in surgeon fixation of the rib fractures.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77202",risUrl:"/chapter/ris/77202",book:{id:"10713",slug:"trauma-and-emergency-surgery"},signatures:"Turkan Dubus",authors:[{id:"233186",title:"Associate Prof.",name:"Turkan",middleName:null,surname:"Dubus",fullName:"Turkan Dubus",slug:"turkan-dubus",email:"drturkandbs@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Clinical examination",level:"1"},{id:"sec_3",title:"3. Diagnostic methods",level:"1"},{id:"sec_3_2",title:"3.1 X-ray",level:"2"},{id:"sec_4_2",title:"3.2 Computed tomography (CT)",level:"2"},{id:"sec_5_2",title:"3.3 Magnetic resonance imaging (MR)",level:"2"},{id:"sec_7",title:"4. Treatment approaches",level:"1"},{id:"sec_7_2",title:"4.1 Medical treatment",level:"2"},{id:"sec_8_2",title:"4.2 Nerve blocks",level:"2"},{id:"sec_9_2",title:"4.3 Surgical fixation",level:"2"},{id:"sec_11",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Marasco SF, Martin K, Niggemeyer L, Summerhayes R, Fitzgerald M, Baileyd M. Impact of rib fixation on quality of life after major trauma with multiple rib fractures. Injury. 2019-01-01, Volume 50, Issue 1, Pages 119-124, DOI: 10.1016/j.injury. 2018.11.005'},{id:"B2",body:'Schuurmans J, Goslings JC, Schepers T. Operative management versus non-operative management of rib fractures in flail chest injuries: a systematic review. Eur J Trauma Emerg Surg. 2017- 43:163-168. DOI: 10.1007/s00068-016-0721-2'},{id:"B3",body:'Negin Sedaghat N, Chiong C, Tjahjono R, Hsu J. Early Outcomes of Surgical Stabilisation of Traumatic Rib Fractures: Single-Center Review With a Real-World Evidence Perspective. Journal of Surgical Research, 2021-08-01, Volume 264, Pages 222-229. DOI: 10.1016/j.jss.2021.02.026'},{id:"B4",body:'Beks R, Peek J, de Jong MB, Wessem KJP, Oner CF, Hietbrink F, Leenen LPH, Groenwold RHH, Houwert RM. Fixation of flail chest or multiple rib fractures: current evidence and how to proceed. A systematic review and meta-analysis. Eur J Trauma Emerg Surg. 2019 Aug;45(4):631-644. DOI: 10.1007/s00068-018-1020-x'},{id:"B5",body:'Zhang, D., Zhou, X., Yang, Y. et al. Minimally invasive surgery rib fracture fixation based on location and anatomical landmarks. Eur J Trauma Emerg Surg 2021. DOI: 10.1007/s00068-021-01676-2'},{id:"B6",body:'Zhang Q , Song L, Ning S, Xie H, Li N, Wang Y. Recent advances in rib fracture fixation. Journal of Thoracic Disease, Vol 11, Suppl 8 May 2019. DOI: 10.21037/jtd.2019.04.99'},{id:"B7",body:'de Jonga MB, Houwert RM, van Heerdea S, de Steenwinkel M, F. Hietbrink F, Leenena LPH. Surgical treatment of rib fracture nonunion: A single center experience. Injury, 2018-03-01, Volume 49, Issue 3, Pages 599-603. DOI: 10.1016/j.injury.2018.01.004'},{id:"B8",body:'Dehghan N. Challenges in plate fixation of chest wall injuries. Injury, 2018-06-01, Volume 49, Pages S39-S43 . DOI: 10.1016/S0020-1383(18)30301-2'},{id:"B9",body:'Nirula R. Postoperative Complications After Rib Fracture Repair. Rib Fracture. Management, 2018, pp 159-163. https://doi.org/10.1007/978-3-319-91644-6_14'},{id:"B10",body:'Agababaoglu I, Hasan Ersöz H. The benefits of early rib fixation for clinical outcomes of flail chest patients in intensive care unit. Turkish Journal of Thoracic and Cardiovascular Surgery 2020;28(2):331-339. DOI: 10.5606/tgkdc.dergisi.2020.18439'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Turkan Dubus",address:"drturkandbs@yahoo.com",affiliation:'
Department of Thoracic Surgery, University of Health Sciences, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey
'}],corrections:null},book:{id:"10713",type:"book",title:"Trauma and Emergency Surgery",subtitle:null,fullTitle:"Trauma and Emergency Surgery",slug:"trauma-and-emergency-surgery",publishedDate:"February 16th 2022",bookSignature:"Selim Sözen and Burhan Hakan Kanat",coverURL:"https://cdn.intechopen.com/books/images_new/10713.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-524-7",printIsbn:"978-1-83969-523-0",pdfIsbn:"978-1-83969-525-4",reviewType:"peer-reviewed",numberOfWosCitations:0,isAvailableForWebshopOrdering:!0,editors:[{id:"90616",title:"Associate Prof.",name:"Selim",middleName:null,surname:"Sözen",slug:"selim-sozen",fullName:"Selim Sözen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"183319",title:"Associate Prof.",name:"Burhan",middleName:"Hakan",surname:"Kanat",slug:"burhan-kanat",fullName:"Burhan Kanat"},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"994"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"77320",type:"chapter",title:"Blunt Abdominal Injury",slug:"blunt-abdominal-injury",totalDownloads:156,totalCrossrefCites:0,signatures:"Pabithadevi B. Mehanathan, Subash Metha, Athisayamani Jeyapaul and Reesha Pa",reviewType:"peer-reviewed",authors:[{id:"351251",title:"Prof.",name:"Pabitha Devi",middleName:null,surname:"B. Mehanathan",fullName:"Pabitha Devi B. Mehanathan",slug:"pabitha-devi-b.-mehanathan"},{id:"418230",title:"Dr.",name:"Subash",middleName:null,surname:"Mehta",fullName:"Subash Mehta",slug:"subash-mehta"},{id:"418231",title:"Dr.",name:"Athisayamani",middleName:null,surname:"Giftson",fullName:"Athisayamani Giftson",slug:"athisayamani-giftson"},{id:"418234",title:"Dr.",name:"Reesha",middleName:null,surname:"Pa",fullName:"Reesha Pa",slug:"reesha-pa"}]},{id:"79481",type:"chapter",title:"Rectus Sheath Hematoma",slug:"rectus-sheath-hematoma",totalDownloads:102,totalCrossrefCites:0,signatures:"Serhat Doğan, Selim Sözen, Burhan Hakan Kanat, Gökhan Söğütlü, Mehmet Gençtürk and Hasan Erdem",reviewType:"peer-reviewed",authors:[{id:"90616",title:"Associate Prof.",name:"Selim",middleName:null,surname:"Sözen",fullName:"Selim Sözen",slug:"selim-sozen"},{id:"183319",title:"Associate Prof.",name:"Burhan",middleName:"Hakan",surname:"Kanat",fullName:"Burhan Kanat",slug:"burhan-kanat"},{id:"169976",title:"Dr.",name:"Hasan",middleName:null,surname:"Erdem",fullName:"Hasan Erdem",slug:"hasan-erdem"},{id:"315199",title:"Dr.",name:"Mehmet",middleName:null,surname:"Gencturk",fullName:"Mehmet Gencturk",slug:"mehmet-gencturk"},{id:"427626",title:"Dr.",name:"Serhat",middleName:null,surname:"Doğan",fullName:"Serhat Doğan",slug:"serhat-dogan"},{id:"427738",title:"Dr.",name:"Gökhan",middleName:null,surname:"Söğütlü",fullName:"Gökhan Söğütlü",slug:"gokhan-sogutlu"}]},{id:"77555",type:"chapter",title:"Blunt Traumatic Aortic Injury",slug:"blunt-traumatic-aortic-injury",totalDownloads:169,totalCrossrefCites:0,signatures:"Domenico Calcaterra",reviewType:"peer-reviewed",authors:[{id:"353908",title:"Associate Prof.",name:"Domenico",middleName:null,surname:"Calcaterra",fullName:"Domenico Calcaterra",slug:"domenico-calcaterra"}]},{id:"77038",type:"chapter",title:"The Role of Minimally Invasive Surgery in Management of Chest Trauma",slug:"the-role-of-minimally-invasive-surgery-in-management-of-chest-trauma",totalDownloads:128,totalCrossrefCites:0,signatures:"Tuba Apaydin",reviewType:"peer-reviewed",authors:[{id:"303399",title:"M.D.",name:"Tuba",middleName:null,surname:"Apaydın",fullName:"Tuba Apaydın",slug:"tuba-apaydin"}]},{id:"77202",type:"chapter",title:"Surgical Approach to Rib Fractures",slug:"surgical-approach-to-rib-fractures",totalDownloads:156,totalCrossrefCites:0,signatures:"Turkan Dubus",reviewType:"peer-reviewed",authors:[{id:"233186",title:"Associate Prof.",name:"Turkan",middleName:null,surname:"Dubus",fullName:"Turkan Dubus",slug:"turkan-dubus"}]},{id:"77595",type:"chapter",title:"Management of Traumatic Brain Injury",slug:"management-of-traumatic-brain-injury",totalDownloads:74,totalCrossrefCites:0,signatures:"Soe Wunna Htay",reviewType:"peer-reviewed",authors:[{id:"352224",title:"Ph.D. Student",name:"Soe Wunna",middleName:null,surname:"Htay",fullName:"Soe Wunna Htay",slug:"soe-wunna-htay"}]},{id:"77886",type:"chapter",title:"Acute Compartment Syndrome of the Extremities and Paraspinal Muscles",slug:"acute-compartment-syndrome-of-the-extremities-and-paraspinal-muscles",totalDownloads:159,totalCrossrefCites:0,signatures:"Balaji Zacharia and Raj Vignesh Selvaraj",reviewType:"peer-reviewed",authors:[{id:"31623",title:"Dr.",name:"Balaji",middleName:null,surname:"Zacharia",fullName:"Balaji Zacharia",slug:"balaji-zacharia"},{id:"415127",title:"Dr.",name:"Raj",middleName:null,surname:"Vignesh",fullName:"Raj Vignesh",slug:"raj-vignesh"}]},{id:"78653",type:"chapter",title:"Management and Clinical Aspects of Burned Patients Affected by SARS-COV2",slug:"management-and-clinical-aspects-of-burned-patients-affected-by-sars-cov2",totalDownloads:115,totalCrossrefCites:0,signatures:"Filippo Andrea Giovanni Perozzo, Alex Pontini, Alberto De Lazzari, Alvise Montanari, Giovanni Valotto and Bruno Azzena",reviewType:"peer-reviewed",authors:[{id:"349373",title:"Dr.",name:"Alex",middleName:null,surname:"Pontini",fullName:"Alex Pontini",slug:"alex-pontini"},{id:"429011",title:"Dr.",name:"Bruno",middleName:null,surname:"Azzena",fullName:"Bruno Azzena",slug:"bruno-azzena"},{id:"429012",title:"Dr.",name:"Filippo Andrea Giovanni",middleName:null,surname:"Perozzo",fullName:"Filippo Andrea Giovanni Perozzo",slug:"filippo-andrea-giovanni-perozzo"},{id:"429014",title:"Dr.",name:"Alvise",middleName:null,surname:"Montanari",fullName:"Alvise Montanari",slug:"alvise-montanari"},{id:"429016",title:"Dr.",name:"Alberto",middleName:null,surname:"De Lazzari",fullName:"Alberto De Lazzari",slug:"alberto-de-lazzari"},{id:"429017",title:"Dr.",name:"Giovanni",middleName:null,surname:"Valotto",fullName:"Giovanni Valotto",slug:"giovanni-valotto"}]}]},relatedBooks:[{type:"book",id:"7936",title:"Surgical Recovery",subtitle:null,isOpenForSubmission:!1,hash:"7ba422a208674f010835a5ad3378b06c",slug:"surgical-recovery",bookSignature:"Selim Sozen",coverURL:"https://cdn.intechopen.com/books/images_new/7936.jpg",editedByType:"Edited by",editors:[{id:"90616",title:"Associate Prof.",name:"Selim",surname:"Sözen",slug:"selim-sozen",fullName:"Selim Sözen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"70432",title:"American Society of Anesthesiologists Physical Status Classification System: History, Development, Reliability, and Its Future",slug:"american-society-of-anesthesiologists-physical-status-classification-system-history-development-reli",signatures:"Sohel M.G. Ahmed, Malek Ahmad Alali, Kathy Lynn Gaviola Atuel and Mogahed Ismail Hassan Hussein",authors:[{id:"205787",title:"Dr.",name:"Sohel Mohamed Gamal",middleName:null,surname:"Ahmed",fullName:"Sohel Mohamed Gamal Ahmed",slug:"sohel-mohamed-gamal-ahmed"},{id:"310363",title:"Dr.",name:"Malek Ahmad",middleName:null,surname:"Alali",fullName:"Malek Ahmad Alali",slug:"malek-ahmad-alali"},{id:"310364",title:"Dr.",name:"Kathy Lynn Gaviola",middleName:null,surname:"Atuel",fullName:"Kathy Lynn Gaviola Atuel",slug:"kathy-lynn-gaviola-atuel"},{id:"310365",title:"Dr.",name:"Mogahed Ismail Hassan",middleName:null,surname:"Hussein",fullName:"Mogahed Ismail Hassan Hussein",slug:"mogahed-ismail-hassan-hussein"}]},{id:"71795",title:"ERAS in General Thoracic Surgery",slug:"eras-in-general-thoracic-surgery",signatures:"Domenico Viggiano, Leonardo Politi, Alessandro Gonfiotti and Andrea Droghetti",authors:[{id:"308554",title:"Dr.",name:"Domenico",middleName:null,surname:"Viggiano",fullName:"Domenico Viggiano",slug:"domenico-viggiano"},{id:"308557",title:"Dr.",name:"Alessandro",middleName:null,surname:"Gonfiotti",fullName:"Alessandro Gonfiotti",slug:"alessandro-gonfiotti"},{id:"308638",title:"Dr.",name:"Andrea",middleName:null,surname:"Droghetti",fullName:"Andrea Droghetti",slug:"andrea-droghetti"},{id:"314691",title:"Prof.",name:"Leonardo",middleName:null,surname:"Politi",fullName:"Leonardo Politi",slug:"leonardo-politi"}]},{id:"69582",title:"Single-Row Versus Double-Row Repair in Rotator Cuff Tears",slug:"single-row-versus-double-row-repair-in-rotator-cuff-tears",signatures:"Michael E. Hantes, Georgios I. Chalatsis and Georgios Mpakagiannis",authors:[{id:"73667",title:"Prof.",name:"Michael E.",middleName:null,surname:"Hantes",fullName:"Michael E. Hantes",slug:"michael-e.-hantes"},{id:"301549",title:"M.D.",name:"George",middleName:"Paraskevas",surname:"Chalatsis",fullName:"George Chalatsis",slug:"george-chalatsis"},{id:"301550",title:"Dr.",name:"George",middleName:null,surname:"Bakagiannis",fullName:"George Bakagiannis",slug:"george-bakagiannis"}]},{id:"72934",title:"Fast Recovery in Esthetic Body Contouring Surgery",slug:"fast-recovery-in-esthetic-body-contouring-surgery",signatures:"Héctor Durán, Lazaro Cardenas Camarena, Jorge Bayter, Juan Carlos Zambrano, Marcelo Uriarte and Alejandro López Echaury",authors:[{id:"67562",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Zambrano Bürgl",fullName:"Juan Carlos Zambrano Bürgl",slug:"juan-carlos-zambrano-burgl"},{id:"310471",title:"Dr.",name:"Hector Cesar",middleName:null,surname:"Duran Vega",fullName:"Hector Cesar Duran Vega",slug:"hector-cesar-duran-vega"},{id:"325384",title:"Dr.",name:"Lazaro",middleName:null,surname:"Cárdenas Camarena",fullName:"Lazaro Cárdenas Camarena",slug:"lazaro-cardenas-camarena"},{id:"325385",title:"Dr.",name:"Jorge",middleName:null,surname:"Bayter",fullName:"Jorge Bayter",slug:"jorge-bayter"},{id:"325386",title:"Dr.",name:"Marcelo",middleName:null,surname:"Uriarte",fullName:"Marcelo Uriarte",slug:"marcelo-uriarte"},{id:"325387",title:"Dr.",name:"Alejandro",middleName:null,surname:"Lopez Echaury",fullName:"Alejandro Lopez Echaury",slug:"alejandro-lopez-echaury"}]},{id:"72437",title:"Surgical Recovery of Intestinal Obstructions: Pre- and Postoperative Care and How Could it Be Prevented?",slug:"surgical-recovery-of-intestinal-obstructions-pre-and-postoperative-care-and-how-could-it-be-prevente",signatures:"Burhan Hakan Kanat, Erhan Eröz, Atakan Saçli, Nizamettin Kutluer, Mehmet Gençtürk and Selim Sözen",authors:[{id:"90616",title:"Associate Prof.",name:"Selim",middleName:null,surname:"Sözen",fullName:"Selim Sözen",slug:"selim-sozen"},{id:"183319",title:"Associate Prof.",name:"Burhan",middleName:"Hakan",surname:"Kanat",fullName:"Burhan Kanat",slug:"burhan-kanat"},{id:"315196",title:"Dr.",name:"Erhan",middleName:null,surname:"Eröz",fullName:"Erhan Eröz",slug:"erhan-eroz"},{id:"315197",title:"Dr.",name:"Atakan",middleName:null,surname:"Saçlı",fullName:"Atakan Saçlı",slug:"atakan-sacli"},{id:"315198",title:"Dr.",name:"Nizamettin",middleName:null,surname:"Kutluer",fullName:"Nizamettin Kutluer",slug:"nizamettin-kutluer"},{id:"315199",title:"Dr.",name:"Mehmet",middleName:null,surname:"Gencturk",fullName:"Mehmet Gencturk",slug:"mehmet-gencturk"}]},{id:"69995",title:"Invasive Aspergillosis in Transplant Recipients",slug:"invasive-aspergillosis-in-transplant-recipients",signatures:"Marta Wróblewska, Beata Sulik-Tyszka, Wojciech Figiel, Grzegorz Niewiński and Krzysztof Zieniewicz",authors:[{id:"303801",title:"Prof.",name:"Marta",middleName:null,surname:"Wroblewska",fullName:"Marta Wroblewska",slug:"marta-wroblewska"},{id:"303802",title:"Dr.",name:"Beata",middleName:null,surname:"Sulik-Tyszka",fullName:"Beata Sulik-Tyszka",slug:"beata-sulik-tyszka"},{id:"303803",title:"Dr.",name:"Wojciech",middleName:null,surname:"Figiel",fullName:"Wojciech Figiel",slug:"wojciech-figiel"},{id:"303804",title:"Prof.",name:"Krzysztof",middleName:null,surname:"Zieniewicz",fullName:"Krzysztof Zieniewicz",slug:"krzysztof-zieniewicz"},{id:"310186",title:"Prof.",name:"Marta",middleName:null,surname:"Wróblewska",fullName:"Marta Wróblewska",slug:"marta-wroblewska"}]}]}],publishedBooks:[{type:"book",id:"6069",title:"Essentials of Spinal Cord Injury Medicine",subtitle:null,isOpenForSubmission:!1,hash:"f0a49e24ebfbb9ed7d02f7daab9b30f6",slug:"essentials-of-spinal-cord-injury-medicine",bookSignature:"Yannis Dionyssiotis",coverURL:"https://cdn.intechopen.com/books/images_new/6069.jpg",editedByType:"Edited by",editors:[{id:"76883",title:"PhD.",name:"Yannis",surname:"Dionyssiotis",slug:"yannis-dionyssiotis",fullName:"Yannis Dionyssiotis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7046",title:"Wound Healing",subtitle:"Current Perspectives",isOpenForSubmission:!1,hash:"fa7b870ad29ce1dfcf6faeafdc060309",slug:"wound-healing-current-perspectives",bookSignature:"Kamil Hakan Dogan",coverURL:"https://cdn.intechopen.com/books/images_new/7046.jpg",editedByType:"Edited by",editors:[{id:"30612",title:"Prof.",name:"Kamil Hakan",surname:"Dogan",slug:"kamil-hakan-dogan",fullName:"Kamil Hakan Dogan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6814",title:"Current Topics in Intensive Care Medicine",subtitle:null,isOpenForSubmission:!1,hash:"5bbe8e72807443305f7cae60bfe79b9e",slug:"current-topics-in-intensive-care-medicine",bookSignature:"R?za Hakan Erbay",coverURL:"https://cdn.intechopen.com/books/images_new/6814.jpg",editedByType:"Edited by",editors:[{id:"169248",title:"Dr.",name:"Rıza Hakan",surname:"Erbay",slug:"riza-hakan-erbay",fullName:"Rıza Hakan Erbay"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7043",title:"Clinical Management of Shock",subtitle:"The Science and Art of Physiological Restoration",isOpenForSubmission:!1,hash:"0f79000187ae93618e2213631e00047c",slug:"clinical-management-of-shock-the-science-and-art-of-physiological-restoration",bookSignature:"Stanislaw P. Stawicki and Mamta Swaroop",coverURL:"https://cdn.intechopen.com/books/images_new/7043.jpg",editedByType:"Edited by",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10296",title:"Special Considerations in Human Airway Management",subtitle:null,isOpenForSubmission:!1,hash:"c11e3ca09bf246ec270063a7198fd33c",slug:"special-considerations-in-human-airway-management",bookSignature:"Nabil A. Shallik",coverURL:"https://cdn.intechopen.com/books/images_new/10296.jpg",editedByType:"Edited by",editors:[{id:"202782",title:"Dr.",name:"Nabil A.",surname:"Shallik",slug:"nabil-a.-shallik",fullName:"Nabil A. Shallik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"76490",title:"Phytochemistry and Ethnopharmacology of Vebris nobilis Delile (Rutaceae)",doi:"10.5772/intechopen.96809",slug:"phytochemistry-and-ethnopharmacology-of-em-vebris-nobilis-em-delile-rutaceae-",body:'
1. Introduction
The genus Teclea Delile subsumed into Vepris Mziray (Rutaceae-Toddalieae) were merged because of their similarity in morphological characteristics [1]. Currently, there are about 86 species in the genus vepris comprising of evergreen shrubs and trees, predominantly of tropical lowland evergreen forest, but with some species extending into submontane forests and some into drier forests and woodland distributed in Africa, Saudi Arabia and India. In Africa, the species in the genus vepris are widely distributed in countries like Ethiopia, Sudan, Somalia, Cameroon, South Africa, Kenya, Uganda and Tanzania [2].
Vepris nobilis Mziray, formerly Teclea noblis Delile (family Rutaceae) is about 2-12 m high but can be much taller in rain forests. Its bark is smooth and gray and has branchlets glabrous. The leaves are trifoliolate, occasionally 2-or 1 foliolate; petiole 1.5–6 cm long, sometimes slightly grooved at the apex usually glabrous. The leaflets are subsessile or with a petiolulate up to 10 mm long, oblong-elliptic, 5–15 cm long, 1.5–4 cm broad, acute to acuminate at the apex, narrowly cuneate at the base, glabrous, but sometimes puberulous on the midrib; lateral nerves numerous. The inflorescence of terminal and axillary panicles 4–15 cm long, glabrous. The flowers are polygamous with four Sepals united into a cupuliform calyx 0.6–0.8 mm long; lobes small, ovate, ciliate., narrowly elliptic, 3.5–4 mm long, 1.5–1.7 mm broad. The male flowers are with 4–5 stamens 3–5.5 mm long; anthers basifixed; rudimentary ovary slender and glabrous while the female flower are with 4 or 5 staminodes 0.5–1.2 mm long. The ovary are subglobose, 1–1.4 mm in diameter, glabrous unilocular, 2-ovulate; style up to 0.5 mm long. The stigma are disk-shaped and peltate, 1 mm in diameter, red, glabrous, barely foveolate, wrinkled when dry and one seeded. Its fruit are yellow, orange or red in color, round or ellipsoid becoming wrinkled 6–8 x 5–6 mm. The seed are ovoid 5.5–6.0 mm long. Vepris nobilis is native to Uganda, Kenya, Tanzania and Ethiopia [3].
2. Ethnomedicinal uses
Vepris nobilis is used in folk or traditional medicine to treat several diseases or illnesses. A decoction of the arial parts of the plant has been reported to treat malaria [4]; stem bark as a remedy for gonorrhea and pain; a mixture of the bark and leaves as analgesics and antipyretic [5, 6]; leaves as a cure for fever [2, 7], pneumonia [3] and malaria [8]; roots for treating rheumatism, arthritis, pneumonia [9, 10], as an anthelminthic [11], weight loss and chronic cough [12]. A decoction of stem bark and root in treating asthma, common cold, headache, join and chest pains [11, 13]. Steam inhalation of the leaves was reported to cures fever [3] and stem bark as a chewing stick for brushing teeth [14].
3. Chemistry
3.1 Extraction yield
The percentage extraction yield of the leaves of V. nobilis with methanol, hexane, dichloromethane and ethyl acetate was found to be 10.95, 2.73, 2.48 and 1.57%, respectively [15]. However, extraction yields for roots with methanol, and a mixture of dichloromethane (DCM) and methanol in the ratio of 1: 1 was found to be 2.12 and 2.36% [16]. Hydro distillation of the leaves of V. nobilis resulted in 0.23% essential oil yield [7].
3.2 Phytochemicals
Phytochemical analyses of the leaves, fruits, roots and stem bark have indicated presence of several phytochemicals. For instance, ethanol extract V. nobilis root bark and the leaves were found to contain tannins, reducing compounds, alkaloids, steroid glycosides, polyuronides, glucides, starch, coumarin derivatives and flavonoids [16, 17]. The fractionation of the different plant part extract has resulted in the identification of several quinoline and furoquinoline alkaloids, terpenoids and flavonoids.
3.2.1 Alkaloids
Alkaloids are organic heterocyclic nitrogen compounds that are weak bases. They form a bicyclic system in which benzene and a pyridine ring are fused together. There are several quinoline, furoquinoline and acridone alkaloids identified in the different plant parts. For instance, furoquinoline alkaloids; tecleabine [18], tecleoxine [7], isotecleoxine [19], methylnkolbisine [5], chlorodesnkolbisine [20], pteleine [21], isohaplopine-3,3-dimethylallylether [22], nobiline [23] haplopine-3,3-dimethylallylether [24] anhydroevoxine [9], kokusaginine [12] and 8-methoxyflindersine [25]; and acridone alkaloid, arborinine [26] were isolated from the aerial parts of V. nobilis [4, 5].
Similarly, furoquinoline alkaloids including nobiline [23], montrifoline [8], skimmiamine [4], flindersiamine [6] and maculine [11] were isolated from the leaves; and isoplatydesmine [2], ribalinine [27] and edilinine [1] isolated from both the leaves and fruits [8]. The fruits of V nobilis fruit were found to contain furoquinoline alkaloids; acetylmontrifoline [10], montrifoline [8], maculine [11], kokusaginine [12] and skimmiamine [4, 8]. The stem bark was found to contain furoquinoline alkaloids, Nkolbisine [28] while the root contained tecleabine [18], N -methylflindersine [29], flindersiamine [6], skimmianine [4] and desloratadine [13, 17].
3.2.2 Terpenoids
Terpenes form the largest group of natural compounds and they are usually identified on the basis of the number of isoprene units they possess. For instance, terpenes with one, two and three isoprene unit are called hemiterpene, monoterpenes and sesquiterpene, respectively. Essential oils mainly comprise of monoterpenes or/and sesquiterpenes. Ocheng et al. [14] and Al-Rehaily [7] evaluated essential oil profile of the roots and leaves respectively. In both studies, Germacrene-D [14] and Ocimene [17] were the major sesquiterpene and monoterpene hydrocarbon (Table 1). A study by Al-Rehaily et al., [19] also isolated sesquiterpenes, teclenone A [30] and teclenone B [31] from the aerial parts while a study by Al-Rehaily et al., [5] isolated lupeol from the leaves of V. nobilis. β-sitosterol was one of the setroids isolated from the aerial parts of V. nobilis [15, 19].
Essential oils from the leaves and roots of V. nobilis.
3.2.3 Flavonoids
Flavonoids are a class of polyphenol phytochemicals made up of a skeleton of 15-carbon atoms which consists of two benzene rings (ring A and B) linked via a heterocyclic pyrane ring [26]. Depending on the chemical structures, flavonoids are divided into clases like anthocyanins, flavones, flavonols, flavanones, dihydroflavonols, chalcones, aurones, flavonons, flavan and proanthocyanidins, isoflavonoids, isoflavones, isoflavonones, isoflavons, isoflavene, biflavonoids, neoflavonoids and flavonoid alkaloids. A study conducted by Al-Rehaily et al. [5] isolated flavanone 4,5-dihydroxy-7- prenyloxyflavanone from aerial parts of V. nobilis [5]. Phytochemical quantification of flavonoids in the roots resulted in 33.5 and 20.6 mg/g. Quercetin Equivalent while quantification of phenolic compounds resulted in 168.4 mg/g Garlic Acid Equivalent.
4. Pharmacological activity
Vepris nobilis has been reported to poses analgesic, antipyretic, anti-malarial, anti-plasmodial, antimicrobial, anti-inflammatory, anti-caseinolytic, anti-leishmanial and anti-trypanosomal activities.
4.1 Antipyretic and analgesic activities
Pyrexia or fever is the increase in body temperature above normal physiological range, which may result due to physiological stress such as during microbial infections as natural defense system of the body is activated [32]. Usually, at the elevated body temperature, there is increased production of proinflammatory mediators’ cytokines such as interleukin 1β, β, α and TNF-α which enhance the formation of prostaglandin E2 (PGE2) near the peptic hypothalamus area and the prostaglandin in turn act on the hypothalamus. To lower the elevated body temperature, antipyretic drugs administered usually inhibit COX-2 expression thereby inhibiting prostaglandin synthesis.
Since V. nobilis is used to treat fevers, a study on the antipyretic and analgesic activity of ethyl acetate fraction from the residue of the 85% ethanol extract of V. nobilis was found to exhibit a significant antipyretic effect in hyperthermic rats and rabbits [32]. Similarly, essential oils of the leaves of V nobilis showed significant analgesic and antipyretic activity recorded in both writhing and tail flick test in mice [7]. Analgesic and antipyretic activity in this study was attributed to Central nervous system depression as observed in the behavioral studies on the animals.
A study conducted by Mascolo et al. [2] by intravenous administration of 50 mg/kg of dried leaf extract of V. nobilis resulted in antipyretic and analgesic activity, and thereby causing decrease in body temperature, with the effect being equipotent to acetylsalicylic acid. The same extract also demonstrated antinociceptive activity as judged by its ability to increase the thermal response latencies of mice kept on heated surface with IC25 of 26.1 mg/kg compared to acetylsalicylic acid with IC25 of 32.5 mg/kg. In a study conducted on antipyretic and analgesic activities of ethanolic extract of V. nobilis, a compound 4,6-dimethoxy-7-((3-methylbuta-1,3-dien-1-yl)oxy)furo [2,3-b]quinolone was found as a good lead compound to be developed into a drug for managing pain.
4.2 Anti inflammatory activity
Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals, or microbiologic agents with the aim to inactivate or destroy the invading organism, remove irritants and set the stage for tissue repair. In the process, proinflammatory cytokines like TNF-α, IL-6, and IL-1β are produced in large quantities by macrophages and monocytes that stimulate the cellular responses via increasing prostaglandins (PGs) and reactive oxygen species [33]***. In laboratory animal experiments, inflammatory pain can be induced by acetic acid due it is ability to induce capillary permeability and liberating endogenous substances that excite pain nerve endings [34].
A study conducted on ethanol extract dose-related effect of V. nobilis extract on carrageenin-induced oedema at high doses of 200-300 mg/kg significantly modified carageenin oedema with IC25 of 157.5 mg/kg compared to acetylsalicylic acid with 22.5 mg/kg [2]. This biological effect was attributed to phytochemicals present in the extract because of their potential to inhibit the cyclooxygenase enzyme in peripheral tissues and interfere with the transduction mechanism of primary afferent nociceptors.
A similar study conducted by Omujal et al. [17] found that 400 and 600 mg ethanolic root bark extract / kg of body weight on formalin induced paw oedema in mice was inhibited much better than by 25 mg of Diclofenac sodium /kg body weight, and indicated that compounds including, N-methylflindersine, Skimmianine, Germacrene-D, α-Cubebene, α-Cardinol and lupeol could be responsible for the anti-inflammatory activity.
4.3 Antimicrobial activity
Microbial infection is the process of invasion of infectious agents into the organism. These infectious agents mainly include bacteria, virus, parasite and fungi naturally occurring in the environment [24]. Antimicrobial activity can be defined as a collective term for all active principles (agents) that inhibit the growth of bacteria, viruses and fungi. Although antibiotics play an essential role in treating microbial infections, extracts of plants have also been attributed to contribute significantly to antibiotic activity. Currently, some of the antimicrobial drugs on the market have been isolated from natural sources.
Studies on the antimicrobial activity of the leaves; stem bark and roots of V. nobilis on gram-negative bacteria (like Escherichia coli), gram-positive bacteria (e.g., Staphylococcus aureus and Bacillus subtilis) and fungi (e.g. Candida albican) has been conducted. For instance, the inhibition zones (in mm) of DCM, hexane, ethyl acetate and methanol crude extracts of the air-dried leaf extracts of V. nobilis showed activity against S. aureus with DCM exhibiting the highest activity among the solvent, though its activity was lower than that of ampicilin or gentamycin. In these solvents, DCM and methanol also registered some activity against S. pneumoniae and B. subtilis.
A study conducted by Kisangau et al. [12] also determined the antimicrobial activity of petroleum ether extract of the leaves of V. nobilis and found activity against B. subtilis and E. coli, though there activities were lower than ampicillin and gentamicin, respectively. Furthermore, antimicrobial activity against S. typhi and E. coli were only realized in DCM and methanol extract. A similar study conducted by Nuru et al. [16] found that methanol root extract of V. nobilis showed promising activity against S. aureus and P.aeruginosa, but not for Klebsiella pneumania and E. coli. When an extract of a mixture of solvents (DCM and methanol in the ratio of 1:1) on the same microorganism was evaluated, the results were contrary. In another study conducted on fractionated furoquinoline alkaloids e.g. maculine and benzoylbetulin isolated from its roots showed antimicrobial activity against S. aureus and P. aeruginosa [16].
Although Onyacha et al. [15] and Kuete et al. [25] found that kokusaginine, dictamine, 8-Dimethoxy-7-(3-methyl-but-2-enyloxy)-furo [2, 3-b] quinoline, and β-Sitosterol isolated from V. nobilis showed activity towards S. aureus and S. pneumonia, Michael [27] had indicated earlier that kokusaginine and dictamine had not exhibited antimicrobial activity towards a range of microorganisms at concentrations even up to 100 g/mL But a study by Kuete et al. [25] also found that that kokusaginine, kolbisine, maculine and lupeol had promising antimicrobial activity on bacteria and fungi. A similar study by Adamska-Szewczyk et al. [18] indicated that dictamine alkaloid possed anti-fungal properties while that of Onyancha et al. [13] indicated that skimmianine alkaloid showed antimicrobial sensitivity to B. subtilis, B. cereus, S. aureus, S. epidermidis, S. pyogenes, Enterobacter aerogenes, Enterococcus spp., E.coli, Klebsiella pneumonia, P. aeruginosa, E. cloacae, Shigella sonnei, Salmonella typhimurium, Burkholderia cepacia, Morganella morganii and Candida albicans, C. tropicali, C. krusei, C. parapslosis, Sacharomyces cerevisae, Cryptococcus neoformans and C. gatti [15].
Although a study by Al-Rehaily [7] indicated no microbiological potential of the essential oil from the leaves against a number of micro-organism, a study by Ocheng et al. [29] reported that essential oils from the root possessed antimicrobial sensitivity to periodontopathic and cariogenic bacteria clinically present in the dental plaque including Aggregatibacter. Actinomycetemcomitans (HK 1519) and Porphyromonas gingivalis (ATCC 33277), Bacillus megaterium (BM11), Streptococcus mutans but not to Lactobacillus acidophilus (NCTC 1723) at concentrations of 0.01%, 0.1 and 1%. An invitro antibacterial study of teclenone A (1) and teclenone B conducted against S. aureus, P. aeruginosa, C. albicans and Cryptococcus neoformans were found to be inactive [19].
4.4 Anti-malarial and antiplasmodial activity
Malaria is one of the major parasitic infection in many tropical and subtropical regions that has contributed the largest burden on public health of most developing countries with global estimates of 600 million new infections annually and at least 1 million of these infections being fatal [35]. Vepris nobilis is one of the medicinal plants used in traditional medicine to treat malaria in rural areas where malaria is the major cause of death. A study conducted by Lacroix et al. [8] on the antiplasmodial activity of ethyl acetate extracts of the fruits and leaves showed that leaves had more activity than the fruits with 98% instead of 55% growth inhibition of Plasmodium falciparum FcB1 strain at 10 mg/ml, respectively [8]. In another study conducted on the stem bark extract of V. nobilis against P. falciparum FcB1 strain (10 μg/mL), 54.7% inhibition was obtained compared to chloroquine with 98.1% Inhibition, and this showed a promising anti-plasmodial activity against P. falciparum. In terms of toxicity on two cell lines, the stem bark extract showed low cyto-toxicity of 36.0% and 22.0% with inhibition of KB cells (10 μg/mL) and MRC5 cells (10 μg/ml), respectively [4].
Further investigation of anti-plasmodial activity of skimmianine alkaloid from the arial parts and leaves of V. nobilis show a weak activity against P. falciparum with cytotoxicity being exhibited towards L-6 cells [18]. A study on the antimalarial activity of kokusaginine and maculine against chloroquine sensitive (CQS) strain of P. falciparum NF54 in vitro with concentrations ranging from 2 to 8 μM showed partial suppression of parasitic growth with significantly different from untreated control group after four days. Montrifoline alkaloid from the fruits of V. nobilis also showed a weak activity against chloroquine- resistant FcB1/Colombia strain of P. falciparum with IC50 of 56 mg/ml compared to chloroquine 0.1 mg/ml, and its cytotoxicity was found to be weak with IC50 with greater than 50 mg/ml. Arborinine alkaloid isolated from arial parts of V. nobilis was found to have moderate antimalarial activity against CQS D10 strain of P.falciparum with IC50 values of 12.3 and 24.5 mM respectively [6].
In another study by Waffo et al. [36] there was antimalarial activity of 12.3 μM of arborinine alkaloid against a Nigerian CQS strain. Similarly, Mwangi et al. [29] found anti-plasmodial activities of arborinine and skimmianine alkaloids from Teclea trichocarpa against chloroquine-resistance strain K1 to be mild with IC50 of 1.61 and 5.60, respectively compared to chloroquine with IC50 of 0.0665 μg/ml.
However, furaquinoline alkaloids including teclealbine, −tecleoxine, isotecleoxine, methylnkolbisine, chlorodesnkolbisine, anhydroevoxine and pteleine were reported to be ineffective in antimalarial tests [4]. Similarly, in vitro antimalarial activity of teclenone A and teclenone B against P. falciparum D6 and W2 clones registered no activity [19].
4.5 Anti-leishmanial and anti-trypanosomal activity
Leishmaniasis is a disease caused by a protozoa parasite from over 20 Leishmania species. Over 90 sandfly species are known to transmit Leishmania parasites through the bites of infected female phlebotomine sandflies which feed on blood to produce eggs [37]. Globally, leishmaniasis disease affects over 350 million people. Although chemotherapeutic therapies including pentavalent antimonials, miltefosine, stibogluconate, amphotericin B and paromomycin are used against leishmaniasis, medicinal plants are also potential sources of lead compounds. A study conducted by Lacroix et al. [4] on the anti-leishmanial activity of montrifoline alkaloid from the leaves of V. nobilis found moderate activity against Leishmania donovani with EC50 of 31.2 mg/ml and no activity against Trypanosoma brucei when compared with pentamidine with EC50 of 3.1 mg/ml. Even Adamska-Szewczyk et al. [18] indicated anti-leishmanial activity of skimmianine activity. Most alkaloids extracted from the fruits and leaves were found not to show Trypanosoma brucei activity with their EC50 being ≥125 mg/ml when compared with that of pentamidine with EC50 of 1.8 mg/ml [4]. N-methyl-8-methoxyflindersin, isolated from the leaves of Raputia heptaphylla was found to show antiparasitic activity against Leishmania promastigotes and amastigotes [38].
4.6 Anti-caseinolytic activity
Snakebite envenomations continue to be a threat to public health in some parts of the world. At least 1,841,000 snakebites resulting in about 94,000 deaths are recorded annually. Venomous snakebites have been traditionally treated with medicinal plants. Pharmacological invitro evaluation of aqueous methanol crude plant extract of V. nobilis demonstrated significant abilities to inhibit the caseinolytic effect of crude Bitis arietans venom and this was related to the higher composition of flavonoids, flavonols and phenolics [20]. Caseinolytic activity is the ratio of the absorbance of casein relative to the absorbance of the venom-casein mixture.
4.6.1 Anthelmintic activity
Helminth infections cause major morbidity and mortality in both human and animals. In developing countries, helminth infections pose a major threat to public health and contribute to the prevalence of malnutrition, anemia, eosinophilia and pneumonia [21]. Anthelmintics can be defined as drugs that either kill or expel infesting helminths or their larvae from the gastrointestinal tract or that live in tissue. Natural products have been found as potential sources for new, effective and safe anthelmintic drug. Although V. nobilis is ethnomedicinally reported to be anthelmintic, a study by Muema et al. [2] on lupeol terpenoid isolated from V. nobiis was found not to show anthelmintic activity.
4.7 Anti-depression activity
Depression is an illness which involves not only mood or emotion disorder but also the physical body and thought process disorder including loss of interest, reduced energy and concentration. This disease is estimated to affect about 21% of the world population. Although there are existing drugs for treatment of depression, they are associated with side effects like dry mouth, fatigue, gastrointestinal or respiratory problems, anxiety, agitation, drowsiness, and cardiac arrhythmias. There are several phytochemicals with antidepressant activity. Adamska-Szewczyk et al. [18] has indicated that alkaloids like kokusaginine and skimmianine in V. nobilis inhibit 5-HT2 receptor activity, thus suggesting their significance in the treatment of various diseases related to serotonin neurotransmission including depression [18].
4.8 Toxicity of V. nobilis
Assessing the safety of medicinal plants has been regarded to be essential even if it has been used for decades. A study by Mailu et al., [11] on toxicity of dichloromethane and ethanol extracts of aerial parts of V. nobilis found mild toxicity and no toxicity to brine shrimp as showed by their LC50 of 75.5 μg/mL and 156.6 μg/mL respectively [10]. In another study using brine shrimp lethality tests conducted on various solvent leaf extracts of V. nobilis including hexane, dichromethane, ethyl acetate and methanol against Artemia salina found LD50 of 235, 165, 557 and 268 respectively [15]. It was concluded that V. nobilis leaf extracts were non-toxic. Brine shrimp results of LC50 < 1.0, 10–30, 30–100 and > 100 μg/mL are regarded highly toxic, toxic, moderately toxic, mildly toxic and none toxic respectively [10]. Even an alkaloid, 6-dimethoxy-7-((3-methylbuta-1,3-dien-1-yl) oxy) furo[2,3- b] quinolone isolated from V. nobilis was predicted with median lethal dose (LD50) of 1600 mg/kg, suggesting its toxicity to be of class 4, which has LD50 between 300 and 2000.
5. Conclusion
Vepris noblis is a rich source of furoquinoline alkaloids, terpenoids and flavonoids. The extracts and phytochemical compounds extracted from the different parts have shown promising pharmacological antimalarial, analgesic, anti-inflammatory and antipyretic activities. Toxicity studies also indicate that V. nobilis is generally safe.
\n',keywords:"Vepris nobilis, Teclea noblis, Phytochemistry, Ethnopharmacology",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76490.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76490.xml",downloadPdfUrl:"/chapter/pdf-download/76490",previewPdfUrl:"/chapter/pdf-preview/76490",totalDownloads:127,totalViews:0,totalCrossrefCites:1,dateSubmitted:"February 2nd 2021",dateReviewed:"February 24th 2021",datePrePublished:"June 24th 2021",datePublished:"May 11th 2022",dateFinished:"April 27th 2021",readingETA:"0",abstract:"Vepris nobilis Mziray (formerly Teclea noblis Delile) is an ever-green plant in the tropical climate. The different parts (leaves, stem bark, roots and fruits) of this plant are popular for treatment of various diseases including; malaria, rheumatism, arthritis, pneumonia, cough, fever, measles, asthma, common cold, headache, join and chest pains and as antithelmintic. Several phytochemical compounds including quinoline and furoquinoline alkaloids, terpenoids and flavonoids have been isolated from the different plant. Pharmacological investigations on the different crude extracts and isolated compounds covering antipyretic, analgesic, anti-inflammatory, antimicrobial, antimalarial, antileishmanial and ant-trypanosomal have been conducted.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76490",risUrl:"/chapter/ris/76490",signatures:"Francis Omujal",book:{id:"11752",type:"book",title:"Natural Drugs from Plants",subtitle:null,fullTitle:"Natural Drugs from Plants",slug:"natural-drugs-from-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-80356-021-2",printIsbn:"978-1-80356-020-5",pdfIsbn:"978-1-80356-022-9",isAvailableForWebshopOrdering:!0,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"341168",title:"Dr.",name:"Francis",middleName:null,surname:"Omujal",fullName:"Francis Omujal",slug:"francis-omujal",email:"fomujal@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Ethnomedicinal uses",level:"1"},{id:"sec_3",title:"3. Chemistry",level:"1"},{id:"sec_3_2",title:"3.1 Extraction yield",level:"2"},{id:"sec_4_2",title:"3.2 Phytochemicals",level:"2"},{id:"sec_4_3",title:"3.2.1 Alkaloids",level:"3"},{id:"sec_5_3",title:"Table 1.",level:"3"},{id:"sec_6_3",title:"3.2.3 Flavonoids",level:"3"},{id:"sec_9",title:"4. Pharmacological activity",level:"1"},{id:"sec_9_2",title:"4.1 Antipyretic and analgesic activities",level:"2"},{id:"sec_10_2",title:"4.2 Anti inflammatory activity",level:"2"},{id:"sec_11_2",title:"4.3 Antimicrobial activity",level:"2"},{id:"sec_12_2",title:"4.4 Anti-malarial and antiplasmodial activity",level:"2"},{id:"sec_13_2",title:"4.5 Anti-leishmanial and anti-trypanosomal activity",level:"2"},{id:"sec_14_2",title:"4.6 Anti-caseinolytic activity",level:"2"},{id:"sec_14_3",title:"4.6.1 Anthelmintic activity",level:"3"},{id:"sec_16_2",title:"4.7 Anti-depression activity",level:"2"},{id:"sec_17_2",title:"4.8 Toxicity of V. nobilis",level:"2"},{id:"sec_19",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Morton, C. M. (2017). Phylogenetic relationships of Vepris (Rutaceae) inferred from chloroplast, nuclear, and morphological data. Plos One, 12(3), e0172708.'},{id:"B2",body:'Mascolo, N., Pinto, A., Capasso, F., Yenesew, A., & Dagne, E. (1988). Antipyretic and analgesic studies of the ethanalic extract of Teclea nobilis delile. Phytotherapy Research, 2(3), 154-156.'},{id:"B3",body:'Orwa et al. 2009: Teclea nobilis. Agroforestry Database 4.0'},{id:"B4",body:'Lacroix, D., Prado, S., Kamoga, D., Kasenene, J., Namukobe, J., Krief, S., ... & Brunois, F. (2011). Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda. Journal of Ethnopharmacology, 133(2), 850-855.'},{id:"B5",body:'Al-Rehaily, A. J., Ahmad, M. S., Muhammad, I., Al-Thukair, A. A., & Perzanowski, H. P. (2003). Furoquinoline alkaloids from Teclea nobilis. Phytochemistry, 64(8), 1405-1411.'},{id:"B6",body:'Magadula, J. J., & Erasto, P. (2009). Bioactive natural products derived from the East African flora. Natural Product Reports, 26(12), 1535-1554.'},{id:"B7",body:'Al-Rehaily, A. J. (2001). Chemical and biological evaluation of essential oil of Teclea nobilis leaf. Pakistan Journal of Biological Sciences, 4(2), 166-168.'},{id:"B8",body:'Lacroix, D., Prado, S., Kamoga, D., Kasenene, J., & Bodo, B. (2012). Absolute configuration of 2′(R)-acetylmontrifoline and 2′(R)-montrifoline, furoquinolines from the fruits of Teclea nobilis. Phytochemistry Letters, 5(1), 22-25.'},{id:"B9",body:'Kigen, G., Kamuren, Z., Njiru, E., Wanjohi, B., & Kipkore, W. (2019). Ethnomedical survey of the plants used by traditional healers in Narok County, Kenya. Evidence-Based Complementary and Alternative Medicine, 2019.'},{id:"B10",body:'Moshi, M. J., Innocent, E., Magadula, J. J., Otieno, D. F., Weisheit, A., Mbabazi, P. K., & Nondo, R. S. O. (2010). Brine shrimp toxicity of some plants used as traditional medicines in Kagera region, north western Tanzania. Tanzania Journal of Health Research, 12(1), 63-67.'},{id:"B11",body:'Mailu, J. K., Nguta, J. M., Mbaria, J. M., & Okumu, M. O. (2020). Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya. Chinese Medicine, 15(1), 1-27.'},{id:"B12",body:'Kisangau, D. P., Lyaruu, H. V., Hosea, K. M., & Joseph, C. C. (2007). Use of traditional medicines in the management of HIV/AIDS opportunistic infections in Tanzania: a case in the Bukoba rural district. Journal of Ethnobiology and Ethnomedicine, 3(1), 1-8.'},{id:"B13",body:'Ngari, W. E., Chiuri, L.W., Kariuki, S.T., and Huckett, S. (2010). Ethnomedicne of Ogiek of River Njoro watershed, Nakuru, Kenya. Ethnobotany Research and Applications, 8, 135-152.'},{id:"B14",body:'Ocheng, F., Bwanga, F., Joloba, M., Softrata, A., Azeem, M., Pütsep, K., ... & Gustafsson, A. (2015). Essential oils from ugandan aromatic medicinal plants: chemical composition and growth inhibitory effects on oral pathogens. Evidence-Based Complementary and Alternative Medicine, 2015.'},{id:"B15",body:'Onyancha, E. M., Tarus, P. K., Machocho, A. K., & Chhabra, S. C. (2014). Phytochemical and antimicrobial studies of Teclea nobilis Del. used in traditional medicine in Kenya. The Journal of Kenya Chemical Society Volume 8: Issue, 8(1), 89.'},{id:"B16",body:'Nuru, A. E. T., Girmay, S., Melaku Y., & Endale M. (2018). Benzoylbetulin from Roots of Teclea nobilis. The Pharmaceutical and Chemical Journal, 5(4):56-62.'},{id:"B17",body:'Omujal, F., Tenda, K. I., Lutoti, S., Kirabo, I., Kasango, S. D., & Nambatya, K. G. (2020). Phytochemistry and anti-inflammatory activity of ethanolic root bark extract of Vepris nobilis Mziray (Rutaceae family). Scientific African, 9, e00484.'},{id:"B18",body:'Adamska-Szewczyk, A., Glowniak, K., & Baj, T. (2016). Furochinoline alkaloids in plants from Rutaceae family–a review. Current Issues in Pharmacy and Medical Sciences, 29(1), 33-38.'},{id:"B19",body:'Al-Rehaily, A. J., Ahmad, M. S., Mossa, J. S., & Muhammad, I. (2002). New Axane and Oppositane Sesquiterpenes from Teclea n obilis. Journal of Natural Products, 65(9), 1374-1376.'},{id:"B20",body:'Chayamiti, T., Mwenje, E., & Mahamadi, C. (2013). Spectrophotometric study of the anti-caseinolytic activity of root extracts of Teclea nobilis and Vepris zambesiaca on Bitis arietans venom. African Journal of Pharmacy and Pharmacology, 7(21), 1420-1425.'},{id:"B21",body:'Das, S. S., Dey, M., & Ghosh, A. K. (2011). Determination of anthelmintic activity of the leaf and bark extract of Tamarindus indica Linn. Indian Journal of Pharmaceutical Sciences, 73(1), 104.'},{id:"B22",body:'Gupta, P. D., & Birdi, T. J. (2017). Development of botanicals to combat antibiotic resistance. Journal of Ayurveda and Integrative Medicine, 8(4), 266-275.'},{id:"B23",body:'Jawaid, T., Gupta, R., & Siddiqui, Z. A. (2011). A review on herbal plants showing antidepressant activity. International Journal of Pharmaceutical Sciences and Research, 2(12), 3051.'},{id:"B24",body:'Khameneh, B., Iranshahy, M., Soheili, V., & Bazzaz, B. S. F. (2019). Review on plant antimicrobials: A mechanistic viewpoint. Antimicrobial Resistance & Infection Control, 8(1), 1-28.'},{id:"B25",body:'Kuete, V., Wansi, J. D., Mbaveng, A. T., Sop, M. K., Tadjong, A. T., Beng, V. P., ... & Lall, N. (2008). Antimicrobial activity of the methanolic extract and compounds from Teclea afzelii (Rutaceae). South African Journal of Botany, 74(4), 572-576.'},{id:"B26",body:'Kulkarni, Y. A., Garud, M. S., Oza, M. J., Barve, K. H., & Gaikwad, A. B. (2016). Diabetes, diabetic complications, and flavonoids. In Fruits, vegetables, and herbs (pp. 77-104). Academic Press.'},{id:"B27",body:'Michael, J. P. (2005). Quinoline, quinazoline and acridone alkaloids. Natural Product Reports, 22(5), 627-646.'},{id:"B28",body:'Muema, S. M., Abuga, K. O., Yenesew, A., & Thoithi, G. N. (2014). Phytochemical and anthelmintic study of the root bark of Teclea Trichocarpa, Engl.(Rutaceae). East and Central African Journal of Pharmaceutical Sciences, 17(2), 44-47.'},{id:"B29",body:'Mwangi, E. S. K., Keriko, J. M., Machocho, A. K., Wanyonyi, A. W., Malebo, H. M., Chhabra, S. C., & Tarus, P. K. (2010). Antiprotozoal activity and cytotoxicity of metabolites from leaves of Teclea trichocarpa. Journal of Medicinal Plants Research, 4(9), 726-731.'},{id:"B30",body:'Njeru, D. N. (2015). Phytochemical investigation of the stem bark and the leaves of Teclea simplicifolia for analgesic activity (Doctoral dissertation, University of Nairobi).'},{id:"B31",body:'Rahman, M. R., Ali, M., Sharif, M., & Tajmim, A. (2017). A review study on the traditional plants has potential antidepressant property. MOJ Cell Sci Rep, 4(5), 00100.'},{id:"B32",body:'Sultana, S., Asif, H. M., Akhtar, N., & Ahmad, K. (2015). Medicinal plants with potential antipyretic activity: A review. Asian Pacific Journal of Tropical Disease, 5, S202-S208.'},{id:"B33",body:'Umamageswari, M. S., & Maniyar, Y. A. (2015). Evaluation of anti-inflammatory activity of aqueous extract of leaves of Solanum melongena linn. in experimental animals. Journal of Clinical and Diagnostic Research: JCDR, 9(1), FF01.'},{id:"B34",body:'Takaki, I., Bersani-Amado, L. E., Vendruscolo, A., Sartoretto, S. M., Diniz, S. P., Bersani-Amado, C. A., & Cuman, R. K. N. (2008). Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models. Journal of Medicinal Food, 11(4), 741-746.'},{id:"B35",body:'Wansi, J. D., Hussain, H., Tcho, A. T., Kouam, S. F., Specht, S., Sarite, S. R., ... & Krohn, K. (2010). Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 24(5), 775-777.'},{id:"B36",body:'Waffo, A. F. K., Coombes, P. H., Crouch, N. R., Mulholland, D. A., El Amin, S. M., & Smith, P. J. (2007). Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa. Phytochemistry, 68(5), 663-667.'},{id:"B37",body:'Raj, S., Sasidharan, S., Balaji, S. N., Dubey, V. K., & Saudagar, P. (2020). Review on natural products as an alternative to contemporary anti-leishmanial therapeutics. Journal of Proteins and Proteomics, 11, 135-158.'},{id:"B38",body:'Torres Suarez, E., Granados-Falla, D. S., Robledo, S. M., Murillo, J., Upegui, Y., & Delgado, G. (2020). Antileishmanial activity of synthetic analogs of the naturally occurring quinolone alkaloid N-methyl-8-methoxyflindersin. Plos One, 15(12), e0243392.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Francis Omujal",address:"fomujal@gmail.com",affiliation:'
Natural Chemotherapeutics Research Institute, Ministry of Health, Kampala, Uganda
'}],corrections:null},book:{id:"11752",type:"book",title:"Natural Drugs from Plants",subtitle:null,fullTitle:"Natural Drugs from Plants",slug:"natural-drugs-from-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-80356-021-2",printIsbn:"978-1-80356-020-5",pdfIsbn:"978-1-80356-022-9",isAvailableForWebshopOrdering:!0,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"96615",title:"MSc.",name:"Alice",middleName:null,surname:"Herlinger",email:"alaschuk@gmail.com",fullName:"Alice Herlinger",slug:"alice-herlinger",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"3",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Universidade Federal do Espírito Santo",institutionURL:null,country:{name:"Brazil"}}},booksEdited:[],chaptersAuthored:[{id:"24574",title:"Breast and Ovarian Cancer Treatment: Facing Forward Women's Health Care",slug:"breast-and-ovarian-cancer-treatment-facing-forward-women-s-health-care",abstract:null,signatures:"Alice Laschuk Herlinger, Klesia Pirola Madeira, Renata Dalmaschio Daltoé, Ian Victor Silva, Marco César Cunegundes Guimarães and Leticia Batista Azevedo Rangel",authors:[{id:"47457",title:"Prof.",name:"Marco",surname:"Guimarães",fullName:"Marco Guimarães",slug:"marco-guimaraes",email:"marco@ccs.ufes.br"},{id:"60339",title:"Prof.",name:"Renata",surname:"Dalto�",fullName:"Renata Dalto�",slug:"renata-dalto",email:"redaltoe@yahoo.com.br"},{id:"60340",title:"Prof.",name:"Ian",surname:"Silva",fullName:"Ian Silva",slug:"ian-silva",email:"iasilva@pq.cnpq.br"},{id:"60359",title:"Dr.",name:"Letícia",surname:"Rangel",fullName:"Letícia Rangel",slug:"leticia-rangel",email:"lbarangel@yahoo.com"},{id:"96614",title:"Dr.",name:"Klesia",surname:"Madeira",fullName:"Klesia Madeira",slug:"klesia-madeira",email:"kleopirola@yahoo.com.br"},{id:"96615",title:"MSc.",name:"Alice",surname:"Herlinger",fullName:"Alice Herlinger",slug:"alice-herlinger",email:"alaschuk@gmail.com"}],book:{id:"374",title:"Current Cancer Treatment",slug:"current-cancer-treatment-novel-beyond-conventional-approaches",productType:{id:"1",title:"Edited Volume"}}},{id:"42057",title:"Conventional Cancer Treatment",slug:"conventional-cancer-treatment",abstract:null,signatures:"Isabella dos Santos Guimarães*, Renata Dalmaschio Daltoé*, Alice\nLaschuk Herlinger, Klesia Pirola Madeira, Taciane Ladislau, Iuri\nCordeiro Valadão, Paulo Cilas Morais Lyra Junior, Sarah Fernandes\nTeixeira, Gustavo Modesto Amorim, Diandra Zipinotti dos Santos,\nKarina Rangel Demuth and Leticia Batista Azevedo Rangel",authors:[{id:"60339",title:"Prof.",name:"Renata",surname:"Dalto�",fullName:"Renata Dalto�",slug:"renata-dalto",email:"redaltoe@yahoo.com.br"},{id:"60359",title:"Dr.",name:"Letícia",surname:"Rangel",fullName:"Letícia Rangel",slug:"leticia-rangel",email:"lbarangel@yahoo.com"},{id:"96614",title:"Dr.",name:"Klesia",surname:"Madeira",fullName:"Klesia Madeira",slug:"klesia-madeira",email:"kleopirola@yahoo.com.br"},{id:"96615",title:"MSc.",name:"Alice",surname:"Herlinger",fullName:"Alice Herlinger",slug:"alice-herlinger",email:"alaschuk@gmail.com"},{id:"165908",title:"BSc.",name:"Taciane",surname:"Ladislau",fullName:"Taciane Ladislau",slug:"taciane-ladislau",email:"taciladislau@hotmail.com"},{id:"165909",title:"BSc.",name:"Isabella",surname:"Guimarães",fullName:"Isabella Guimarães",slug:"isabella-guimaraes",email:"isasguimaraes@hotmail.com"},{id:"165910",title:"Ms.",name:"Sarah",surname:"Teixeira",fullName:"Sarah Teixeira",slug:"sarah-teixeira",email:"sarah@multicast.com.br"},{id:"165911",title:"Mr.",name:"Paulo",surname:"Lyra-Junior",fullName:"Paulo Lyra-Junior",slug:"paulo-lyra-junior",email:"pj_lab@yahoo.com.br"},{id:"165912",title:"Mr.",name:"Iuri",surname:"Valadão",fullName:"Iuri Valadão",slug:"iuri-valadao",email:"iuricv__@hotmail.com"},{id:"165918",title:"MSc.",name:"Gustavo",surname:"Amorim",fullName:"Gustavo Amorim",slug:"gustavo-amorim",email:"gustavomamor@gmail.com"},{id:"165919",title:"Ms.",name:"Diandra",surname:"Santos",fullName:"Diandra Santos",slug:"diandra-santos",email:"didizip3@hotmail.com"},{id:"165920",title:"Dr.",name:"Karina",surname:"Demuth",fullName:"Karina Demuth",slug:"karina-demuth",email:"karinarangeldemuth@yahoo.com.br"}],book:{id:"3273",title:"Cancer Treatment",slug:"cancer-treatment-conventional-and-innovative-approaches",productType:{id:"1",title:"Edited Volume"}}},{id:"44426",title:"Target Cancer Therapy",slug:"target-cancer-therapy",abstract:null,signatures:"Taciane Ladislau, Klesia P Madeira, Renata D Daltoé, Isabella S\nGuimarães, Sarah F Teixeira, Paulo CM Lyra-Júnior, Iuri C Valadão,\nLeticia BA Rangel and Alice L Herlinger",authors:[{id:"60339",title:"Prof.",name:"Renata",surname:"Dalto�",fullName:"Renata Dalto�",slug:"renata-dalto",email:"redaltoe@yahoo.com.br"},{id:"60359",title:"Dr.",name:"Letícia",surname:"Rangel",fullName:"Letícia Rangel",slug:"leticia-rangel",email:"lbarangel@yahoo.com"},{id:"96614",title:"Dr.",name:"Klesia",surname:"Madeira",fullName:"Klesia Madeira",slug:"klesia-madeira",email:"kleopirola@yahoo.com.br"},{id:"96615",title:"MSc.",name:"Alice",surname:"Herlinger",fullName:"Alice Herlinger",slug:"alice-herlinger",email:"alaschuk@gmail.com"},{id:"165908",title:"BSc.",name:"Taciane",surname:"Ladislau",fullName:"Taciane Ladislau",slug:"taciane-ladislau",email:"taciladislau@hotmail.com"},{id:"165909",title:"BSc.",name:"Isabella",surname:"Guimarães",fullName:"Isabella Guimarães",slug:"isabella-guimaraes",email:"isasguimaraes@hotmail.com"},{id:"165910",title:"Ms.",name:"Sarah",surname:"Teixeira",fullName:"Sarah Teixeira",slug:"sarah-teixeira",email:"sarah@multicast.com.br"},{id:"165911",title:"Mr.",name:"Paulo",surname:"Lyra-Junior",fullName:"Paulo Lyra-Junior",slug:"paulo-lyra-junior",email:"pj_lab@yahoo.com.br"},{id:"165912",title:"Mr.",name:"Iuri",surname:"Valadão",fullName:"Iuri Valadão",slug:"iuri-valadao",email:"iuricv__@hotmail.com"}],book:{id:"3273",title:"Cancer Treatment",slug:"cancer-treatment-conventional-and-innovative-approaches",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"47457",title:"Prof.",name:"Marco",surname:"Guimarães",slug:"marco-guimaraes",fullName:"Marco Guimarães",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"55375",title:"Dr.",name:"Yukihide",surname:"Kanemitsu",slug:"yukihide-kanemitsu",fullName:"Yukihide Kanemitsu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"59094",title:"Prof.",name:"Marcos",surname:"Paiva",slug:"marcos-paiva",fullName:"Marcos Paiva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"60339",title:"Prof.",name:"Renata",surname:"Dalto�",slug:"renata-dalto",fullName:"Renata Dalto�",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"60340",title:"Prof.",name:"Ian",surname:"Silva",slug:"ian-silva",fullName:"Ian Silva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"60359",title:"Dr.",name:"Letícia",surname:"Rangel",slug:"leticia-rangel",fullName:"Letícia Rangel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/60359/images/system/60359.jpeg",biography:"Leticia B. A. Rangel, Pharm.D., Ph.D., is a Full Professor of the Department of Pharmaceutical Sciences, as well as a member of the Biotechnology Program/RENORBIO and the Biochemistry and Pharmacology Program at the Federal University of Espirito Santo (UFES). As the Head of the Laboratory of Cellular and Molecular Biology of Human Cancer, she coordinates projects on ovarian and breast cancers, with emphasis on the cellular and molecular mechanisms of these diseases, the development of biotechnology products and processes, and the discovery of new anticancer molecules. Her scientific network includes the Institute of Biophysics Carlos Chagas Filho (Federal University of Rio de Janeiro), the Division of Clinical Research of the Brazilian National Cancer Institute, The Department of Molecular Medicine, University of Texas at San Antonio (USA), the H. Lee Moffitt Cancer Center (USA), and the Department of Pathology at the John Hopkins University (USA), as well as the private sector. Aside from papers published in international journals, and ongoing patent negotiations, she has been awarded by the Brazilian government in recognition to her contribution in cancer research.",institutionString:"Federal University of Espirito Santo",institution:{name:"Universidade Federal do Espírito Santo",institutionURL:null,country:{name:"Brazil"}}},{id:"60990",title:"Prof.",name:"Joel",surname:"Sercarz",slug:"joel-sercarz",fullName:"Joel Sercarz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"96614",title:"Dr.",name:"Klesia",surname:"Madeira",slug:"klesia-madeira",fullName:"Klesia Madeira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal do Espírito Santo",institutionURL:null,country:{name:"Brazil"}}},{id:"119443",title:"Dr.",name:"Marcel",surname:"Palumbo",slug:"marcel-palumbo",fullName:"Marcel Palumbo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"119445",title:"Dr.",name:"Barbara",surname:"Greggio",slug:"barbara-greggio",fullName:"Barbara Greggio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}}]},generic:{page:{slug:"open-access-funding-funders-list",title:"List of Funders by Country",intro:"
If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
IMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
",metaTitle:"List of Funders by Country",metaDescription:"If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).",metaKeywords:null,canonicalURL:"/page/open-access-funding-funders-list",contentRaw:'[{"type":"htmlEditorComponent","content":"
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
\n
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6630},{group:"region",caption:"Middle and South America",value:2,count:5911},{group:"region",caption:"Africa",value:3,count:2404},{group:"region",caption:"Asia",value:4,count:12562},{group:"region",caption:"Australia and Oceania",value:5,count:1009},{group:"region",caption:"Europe",value:6,count:17573}],offset:12,limit:12,total:132971},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"-dateEndThirdStepPublish",src:"C-T-0"},books:[{type:"book",id:"9985",title:"Geostatistics",subtitle:null,isOpenForSubmission:!0,hash:"423cb3896195a618c4acb493ce4fd23d",slug:null,bookSignature:"Prof. Jeffrey M. Yarus, Dr. Marko Maucec, Dr. Timothy C. Coburn and Associate Prof. Michael Pyrcz",coverURL:"https://cdn.intechopen.com/books/images_new/9985.jpg",editedByType:null,editors:[{id:"78011",title:"Prof.",name:"Jeffrey M.",surname:"Yarus",slug:"jeffrey-m.-yarus",fullName:"Jeffrey M. Yarus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11983",title:"Biomedical Signal and Image Processing",subtitle:null,isOpenForSubmission:!0,hash:"81ebecb28b5cad564075e6f5b2dc7355",slug:null,bookSignature:"Distinguished Prof. Lulu Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11983.jpg",editedByType:null,editors:[{id:"257388",title:"Distinguished Prof.",name:"Lulu",surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12058",title:"Future Housing",subtitle:null,isOpenForSubmission:!0,hash:"e7f4a1e57fab392b61156956c1247b9e",slug:null,bookSignature:"Dr. Ivan Oropeza-Perez and Dr. Astrid Helena Petzold-Rodríguez",coverURL:"https://cdn.intechopen.com/books/images_new/12058.jpg",editedByType:null,editors:[{id:"282172",title:"Dr.",name:"Ivan",surname:"Oropeza-Perez",slug:"ivan-oropeza-perez",fullName:"Ivan Oropeza-Perez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12006",title:"Advances in Clay Science and Technology",subtitle:null,isOpenForSubmission:!0,hash:"64e16abe1a29e6bf30c582970a5bc1ed",slug:null,bookSignature:"Prof. Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/12006.jpg",editedByType:null,editors:[{id:"7153",title:"Prof.",name:"Gustavo",surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12033",title:"Recent Updates in HVAC Systems",subtitle:null,isOpenForSubmission:!0,hash:"c911b61042fae2c465f4ee69077e0a4b",slug:null,bookSignature:"Dr. César Martín-Gómez",coverURL:"https://cdn.intechopen.com/books/images_new/12033.jpg",editedByType:null,editors:[{id:"76725",title:"Dr.",name:"César",surname:"Martín-Gómez",slug:"cesar-martin-gomez",fullName:"César Martín-Gómez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12034",title:"Underwater Acoustics - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"220f7e2a9580345ffbfaa433f1ca858e",slug:null,bookSignature:"Dr. Jie Deng",coverURL:"https://cdn.intechopen.com/books/images_new/12034.jpg",editedByType:null,editors:[{id:"428272",title:"Dr.",name:"Jie",surname:"Deng",slug:"jie-deng",fullName:"Jie Deng"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12162",title:"Helicobacter pylori Infection - An Up to Date on the Pathogenic Mechanisms, Diagnosis and Clinical Management",subtitle:null,isOpenForSubmission:!0,hash:"03c019e4753a62191c6b0c84cde99283",slug:null,bookSignature:"Dr. Daniela Cornelia Lazar",coverURL:"https://cdn.intechopen.com/books/images_new/12162.jpg",editedByType:null,editors:[{id:"26188",title:"Dr.",name:"Daniela Cornelia",surname:"Lazar",slug:"daniela-cornelia-lazar",fullName:"Daniela Cornelia Lazar"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11690",title:"COVID-19 Drug Development - Recent Advances, New Perspectives, and Applications",subtitle:null,isOpenForSubmission:!0,hash:"f8092a491f68ca0b63cc6d40936a010a",slug:null,bookSignature:"Dr. Arli Aditya Parikesit",coverURL:"https://cdn.intechopen.com/books/images_new/11690.jpg",editedByType:null,editors:[{id:"72288",title:"Dr.",name:"Arli Aditya",surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11952",title:"Response Surface Methodology - Research Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"a22fd44ae22d422a792470bb5c441a81",slug:null,bookSignature:"Prof. Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/11952.jpg",editedByType:null,editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11612",title:"Landraces - Its Productive Conservation",subtitle:null,isOpenForSubmission:!0,hash:"9c3ea2c2248cc3c8a2888e525c732c26",slug:null,bookSignature:"Emeritus Prof. Arnoldo González-Reyna and Dr. Prashant Kaushik",coverURL:"https://cdn.intechopen.com/books/images_new/11612.jpg",editedByType:null,editors:[{id:"470479",title:"Emeritus Prof.",name:"Arnoldo",surname:"González-Reyna",slug:"arnoldo-gonzalez-reyna",fullName:"Arnoldo González-Reyna"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11918",title:"LabVIEW - Virtual Instrumentation in Education and Industry",subtitle:null,isOpenForSubmission:!0,hash:"789e06b22e11ce2be68ba43311d46abd",slug:null,bookSignature:"Dr. Petru Adrian Cotfas, Dr. Daniel Tudor Cotfas and Dr. Horia Hedesiu",coverURL:"https://cdn.intechopen.com/books/images_new/11918.jpg",editedByType:null,editors:[{id:"460635",title:"Dr.",name:"Petru Adrian",surname:"Cotfas",slug:"petru-adrian-cotfas",fullName:"Petru Adrian Cotfas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:42},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:24},{group:"topic",caption:"Computer and Information Science",value:9,count:19},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:18},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:29},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:124},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:3},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:3}],offset:12,limit:12,total:424},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3385,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1875,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3842,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3008,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1109,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1010,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3918,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",publishedDate:"May 11th 2022",numberOfDownloads:1654,editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7686,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3444,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10522",title:"Coding Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"6357e1dd7d38adeb519ca7a10dc9e5a0",slug:"coding-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Sudhakar Radhakrishnan and Sudev Naduvath",coverURL:"https://cdn.intechopen.com/books/images_new/10522.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"26327",title:"Dr.",name:"Sudhakar",middleName:null,surname:"Radhakrishnan",slug:"sudhakar-radhakrishnan",fullName:"Sudhakar Radhakrishnan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10821",title:"Automation and Control",subtitle:"Theories and Applications",isOpenForSubmission:!1,hash:"18463c2291ba306c4dcbabd988227eea",slug:"automation-and-control-theories-and-applications",bookSignature:"Elmer P. Dadios",coverURL:"https://cdn.intechopen.com/books/images_new/10821.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. Dadios"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11348",title:"Mutagenesis and Mitochondrial-Associated Pathologies",subtitle:null,isOpenForSubmission:!1,hash:"001972b3c5b49367314b13025a449232",slug:"mutagenesis-and-mitochondrial-associated-pathologies",bookSignature:"Michael Fasullo and Angel Catala",coverURL:"https://cdn.intechopen.com/books/images_new/11348.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"258231",title:"Dr.",name:"Michael",middleName:"Thomas",surname:"Fasullo",slug:"michael-fasullo",fullName:"Michael Fasullo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11123",title:"Epoxy-Based Composites",subtitle:null,isOpenForSubmission:!1,hash:"c1c5447cf3b9d6c7688276ac30e80de6",slug:"epoxy-based-composites",bookSignature:"Samson Jerold Samuel Chelladurai, Ramesh Arthanari and M.R.Meera",coverURL:"https://cdn.intechopen.com/books/images_new/11123.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"247421",title:"Dr.",name:"Samson Jerold Samuel",middleName:null,surname:"Chelladurai",slug:"samson-jerold-samuel-chelladurai",fullName:"Samson Jerold Samuel Chelladurai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10632",title:"Theory and Practice of Tunnel Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7ba17749f9d0b6a62d584a3c320a1f49",slug:"theory-and-practice-of-tunnel-engineering",bookSignature:"Hasan Tosun",coverURL:"https://cdn.intechopen.com/books/images_new/10632.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"79083",title:"Prof.",name:"Hasan",middleName:null,surname:"Tosun",slug:"hasan-tosun",fullName:"Hasan Tosun"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10906",title:"Fungal Reproduction and Growth",subtitle:null,isOpenForSubmission:!1,hash:"f84de0280d54f3b52e3e4585cff24ac1",slug:"fungal-reproduction-and-growth",bookSignature:"Sadia Sultan and Gurmeet Kaur Surindar Singh",coverURL:"https://cdn.intechopen.com/books/images_new/10906.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"176737",title:"Dr.",name:"Sadia",middleName:null,surname:"Sultan",slug:"sadia-sultan",fullName:"Sadia Sultan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10914",title:"Effective Elimination of Structural Racism",subtitle:null,isOpenForSubmission:!1,hash:"f6a2562646c0fd664aca8335bc3b3e69",slug:"effective-elimination-of-structural-racism",bookSignature:"Erick Guerrero",coverURL:"https://cdn.intechopen.com/books/images_new/10914.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"294761",title:"Dr.",name:"Erick",middleName:null,surname:"Guerrero",slug:"erick-guerrero",fullName:"Erick Guerrero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10664",title:"Animal Reproduction",subtitle:null,isOpenForSubmission:!1,hash:"2d66af42fb17d0a6556bb9ef28e273c7",slug:"animal-reproduction",bookSignature:"Yusuf Bozkurt and Mustafa Numan Bucak",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10940",title:"Plant Hormones",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"5aae8a345f8047ed528914ff3491f643",slug:"plant-hormones-recent-advances-new-perspectives-and-applications",bookSignature:"Christophe Hano",coverURL:"https://cdn.intechopen.com/books/images_new/10940.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10207",title:"Sexual Abuse",subtitle:"An Interdisciplinary Approach",isOpenForSubmission:!1,hash:"e1ec1d5a7093490df314d7887e0b3809",slug:"sexual-abuse-an-interdisciplinary-approach",bookSignature:"Ersi Kalfoğlu and Sotirios Kalfoglou",coverURL:"https://cdn.intechopen.com/books/images_new/10207.jpg",editedByType:"Edited by",publishedDate:"May 25th 2022",editors:[{id:"68678",title:"Dr.",name:"Ersi",middleName:null,surname:"Kalfoglou",slug:"ersi-kalfoglou",fullName:"Ersi Kalfoglou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"18",title:"Neuroscience",slug:"life-sciences-neuroscience",parent:{id:"2",title:"Life Sciences",slug:"life-sciences"},numberOfBooks:65,numberOfSeries:0,numberOfAuthorsAndEditors:1649,numberOfWosCitations:1070,numberOfCrossrefCitations:727,numberOfDimensionsCitations:1699,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"18",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10922",title:"Music in Health and Diseases",subtitle:null,isOpenForSubmission:!1,hash:"6a079df045b086b404399c5ed4ac049a",slug:"music-in-health-and-diseases",bookSignature:"Amit Agrawal, Roshan Sutar and Anvesh Jallapally",coverURL:"https://cdn.intechopen.com/books/images_new/10922.jpg",editedByType:"Edited by",editors:[{id:"100142",title:"Prof.",name:"Amit",middleName:null,surname:"Agrawal",slug:"amit-agrawal",fullName:"Amit Agrawal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10554",title:"Proprioception",subtitle:null,isOpenForSubmission:!1,hash:"e104e615fbd94caa987df3a8d8b3fb8b",slug:"proprioception",bookSignature:"José A. Vega and Juan Cobo",coverURL:"https://cdn.intechopen.com/books/images_new/10554.jpg",editedByType:"Edited by",editors:[{id:"59892",title:"Prof.",name:"José A.",middleName:null,surname:"Vega",slug:"jose-a.-vega",fullName:"José A. Vega"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9853",title:"Connectivity and Functional Specialization in the Brain",subtitle:null,isOpenForSubmission:!1,hash:"79f611488f3217579b5c84978f870863",slug:"connectivity-and-functional-specialization-in-the-brain",bookSignature:"Thomas Heinbockel and Yongxia Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/9853.jpg",editedByType:"Edited by",editors:[{id:"70569",title:"Dr.",name:"Thomas",middleName:null,surname:"Heinbockel",slug:"thomas-heinbockel",fullName:"Thomas Heinbockel"}],equalEditorOne:{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",biography:"Yongxia Zhou obtained a Ph.D. in Biomedical Imaging from the University of Southern California. Her research interest is radiology and neuroscience technology and application. She had been trained as an imaging scientist at several prestigious institutes including Columbia University, the University of Pennsylvania, and the National Institutes of Health (NIH). Her research focuses on multi-modal neuroimaging integration such as MRI/PET and EEG/MEG instrumentation to make the best use of multiple modalities for better interpretation of underlying disease mechanisms. She is the author and editor of more than twelve books for well-known publishers including IntechOpen and Nova Science. She has published more than 100 papers and abstracts in many reputed international journals and conferences and served as reviewer and editor for several academic associations.",institutionString:"University of Southern California",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9629",title:"Electroencephalography",subtitle:"From Basic Research to Clinical Applications",isOpenForSubmission:!1,hash:"8147834b6c6deeeec40f407c71ad60b4",slug:"electroencephalography-from-basic-research-to-clinical-applications",bookSignature:"Hideki Nakano",coverURL:"https://cdn.intechopen.com/books/images_new/9629.jpg",editedByType:"Edited by",editors:[{id:"196461",title:"Prof.",name:"Hideki",middleName:null,surname:"Nakano",slug:"hideki-nakano",fullName:"Hideki Nakano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10475",title:"Smart Biofeedback",subtitle:"Perspectives and Applications",isOpenForSubmission:!1,hash:"8d2bd9997707c905959eaa41e55ba8f1",slug:"smart-biofeedback-perspectives-and-applications",bookSignature:"Edward Da-Yin Liao",coverURL:"https://cdn.intechopen.com/books/images_new/10475.jpg",editedByType:"Edited by",editors:[{id:"3875",title:"Dr.",name:"Edward Da-Yin",middleName:null,surname:"Liao",slug:"edward-da-yin-liao",fullName:"Edward Da-Yin Liao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8059",title:"Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice",subtitle:null,isOpenForSubmission:!1,hash:"8cc2c649900edf37ff3374fdc96a1586",slug:"neurostimulation-and-neuromodulation-in-contemporary-therapeutic-practice",bookSignature:"Denis Larrivee and Seyed Mansoor Rayegani",coverURL:"https://cdn.intechopen.com/books/images_new/8059.jpg",editedByType:"Edited by",editors:[{id:"206412",title:"Prof.",name:"Denis",middleName:null,surname:"Larrivee",slug:"denis-larrivee",fullName:"Denis Larrivee"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8851",title:"Advances in Neural Signal Processing",subtitle:null,isOpenForSubmission:!1,hash:"a44ac118b233b29a3d5b57d61680ec38",slug:"advances-in-neural-signal-processing",bookSignature:"Ramana Vinjamuri",coverURL:"https://cdn.intechopen.com/books/images_new/8851.jpg",editedByType:"Edited by",editors:[{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8751",title:"Somatosensory and Motor Research",subtitle:null,isOpenForSubmission:!1,hash:"86191c18f06e524e0f97a5534fdb2b4c",slug:"somatosensory-and-motor-research",bookSignature:"Toshiaki Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/8751.jpg",editedByType:"Edited by",editors:[{id:"70872",title:"Prof.",name:"Toshiaki",middleName:null,surname:"Suzuki",slug:"toshiaki-suzuki",fullName:"Toshiaki Suzuki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9347",title:"Neuroimaging",subtitle:"Neurobiology, Multimodal and Network Applications",isOpenForSubmission:!1,hash:"a3479e76c6ac538aac76409c9efb7e41",slug:"neuroimaging-neurobiology-multimodal-and-network-applications",bookSignature:"Yongxia Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/9347.jpg",editedByType:"Edited by",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8938",title:"Inhibitory Control Training",subtitle:"A Multidisciplinary Approach",isOpenForSubmission:!1,hash:"bd82354f3bba4af5421337cd42052f86",slug:"inhibitory-control-training-a-multidisciplinary-approach",bookSignature:"Sara Palermo and Massimo Bartoli",coverURL:"https://cdn.intechopen.com/books/images_new/8938.jpg",editedByType:"Edited by",editors:[{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6998",title:"Synucleins",subtitle:"Biochemistry and Role in Diseases",isOpenForSubmission:!1,hash:"2b4b802fec508928ce8ab9deebd1375f",slug:"synucleins-biochemistry-and-role-in-diseases",bookSignature:"Andrei Surguchov",coverURL:"https://cdn.intechopen.com/books/images_new/6998.jpg",editedByType:"Edited by",editors:[{id:"266540",title:"Dr.",name:"Andrei",middleName:null,surname:"Surguchov",slug:"andrei-surguchov",fullName:"Andrei Surguchov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:65,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"46296",doi:"10.5772/57398",title:"Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity",slug:"physiological-role-of-amyloid-beta-in-neural-cells-the-cellular-trophic-activity",totalDownloads:5886,totalCrossrefCites:18,totalDimensionsCites:31,abstract:null,book:{id:"3846",slug:"neurochemistry",title:"Neurochemistry",fullTitle:"Neurochemistry"},signatures:"M. del C. Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. Gómez-Virgilio, G. Ramírez-Rodríguez, E. Vera-\nArroyo, R. Fiorentino-Pérez, U. García, J. Luna-Muñoz and M.A.\nMeraz-Ríos",authors:[{id:"42225",title:"Dr.",name:"Jose",middleName:null,surname:"Luna-Muñoz",slug:"jose-luna-munoz",fullName:"Jose Luna-Muñoz"},{id:"114746",title:"Dr.",name:"Marco",middleName:null,surname:"Meraz-Ríos",slug:"marco-meraz-rios",fullName:"Marco Meraz-Ríos"},{id:"169616",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Cardenas-Aguayo",slug:"maria-del-carmen-cardenas-aguayo",fullName:"Maria del Carmen Cardenas-Aguayo"},{id:"169857",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Silva-Lucero",slug:"maria-del-carmen-silva-lucero",fullName:"Maria del Carmen Silva-Lucero"},{id:"169858",title:"Dr.",name:"Maribel",middleName:null,surname:"Cortes-Ortiz",slug:"maribel-cortes-ortiz",fullName:"Maribel Cortes-Ortiz"},{id:"169859",title:"Dr.",name:"Berenice",middleName:null,surname:"Jimenez-Ramos",slug:"berenice-jimenez-ramos",fullName:"Berenice Jimenez-Ramos"},{id:"169860",title:"Dr.",name:"Laura",middleName:null,surname:"Gomez-Virgilio",slug:"laura-gomez-virgilio",fullName:"Laura Gomez-Virgilio"},{id:"169861",title:"Dr.",name:"Gerardo",middleName:null,surname:"Ramirez-Rodriguez",slug:"gerardo-ramirez-rodriguez",fullName:"Gerardo Ramirez-Rodriguez"},{id:"169862",title:"Dr.",name:"Eduardo",middleName:null,surname:"Vera-Arroyo",slug:"eduardo-vera-arroyo",fullName:"Eduardo Vera-Arroyo"},{id:"169863",title:"Dr.",name:"Rosana Sofia",middleName:null,surname:"Fiorentino-Perez",slug:"rosana-sofia-fiorentino-perez",fullName:"Rosana Sofia Fiorentino-Perez"},{id:"169864",title:"Dr.",name:"Ubaldo",middleName:null,surname:"Garcia",slug:"ubaldo-garcia",fullName:"Ubaldo Garcia"}]},{id:"58070",doi:"10.5772/intechopen.72427",title:"MRI Medical Image Denoising by Fundamental Filters",slug:"mri-medical-image-denoising-by-fundamental-filters",totalDownloads:2564,totalCrossrefCites:17,totalDimensionsCites:30,abstract:"Nowadays Medical imaging technique Magnetic Resonance Imaging (MRI) plays an important role in medical setting to form high standard images contained in the human brain. MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7157,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1439,totalCrossrefCites:13,totalDimensionsCites:23,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4558,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:9,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",slug:"arli-aditya-parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",slug:"cesar-lopez-camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]},overviewPageOFChapters:{paginationCount:18,paginationItems:[{id:"81778",title:"Influence of Mechanical Properties of Biomaterials on the Reconstruction of Biomedical Parts via Additive Manufacturing Techniques: An Overview",doi:"10.5772/intechopen.104465",signatures:"Babatunde Olamide Omiyale, Akeem Abiodun Rasheed, Robinson Omoboyode Akinnusi and Temitope Olumide Olugbade",slug:"influence-of-mechanical-properties-of-biomaterials-on-the-reconstruction-of-biomedical-parts-via-add",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:null,authors:null,book:{title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11405.jpg",subseries:{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering"}}},{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},overviewPagePublishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null}]},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:50,paginationItems:[{id:"81927",title:"Purinergic System in Immune Response",doi:"10.5772/intechopen.104485",signatures:"Yerly Magnolia Useche Salvador",slug:"purinergic-system-in-immune-response",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. Alhazzaa, Thomas Heinbockel and Antonei B. Csoka",slug:"diabetes-and-epigenetics",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81580",title:"Graft-Versus-Host Disease: Pathogenesis and Treatment",doi:"10.5772/intechopen.104450",signatures:"Shin Mukai",slug:"graft-versus-host-disease-pathogenesis-and-treatment",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81533",title:"Prenylation of Natural Products: An Overview",doi:"10.5772/intechopen.104636",signatures:"Kantharaju Kamanna and Aravind Kamath",slug:"prenylation-of-natural-products-an-overview",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kantharaju",surname:"Kamanna"}],book:{title:"Modifications of Biomolecules",coverURL:"https://cdn.intechopen.com/books/images_new/11098.jpg",subseries:null}},{id:"81067",title:"Encapsulation of Essential Oils and Their Use in Food Applications",doi:"10.5772/intechopen.103147",signatures:"Hamdy A. Shaaban and Amr Farouk",slug:"encapsulation-of-essential-oils-and-their-use-in-food-applications",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}}]},subseriesFiltersForOFChapters:[{caption:"Proteomics",value:18,count:3,group:"subseries"},{caption:"Metabolism",value:17,count:10,group:"subseries"},{caption:"Cell and Molecular Biology",value:14,count:17,group:"subseries"},{caption:"Chemical Biology",value:15,count:19,group:"subseries"}],publishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9959",title:"Biomedical Signal and Image Processing",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9959.jpg",slug:"biomedical-signal-and-image-processing",publishedDate:"April 14th 2021",editedByType:"Edited by",bookSignature:"Yongxia Zhou",hash:"22b87a09bd6df065d78c175235d367c8",volumeInSeries:10,fullTitle:"Biomedical Signal and Image Processing",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",institutionString:"University of Southern California",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9973",title:"Data Acquisition",subtitle:"Recent Advances and Applications in Biomedical Engineering",coverURL:"https://cdn.intechopen.com/books/images_new/9973.jpg",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering",publishedDate:"March 17th 2021",editedByType:"Edited by",bookSignature:"Bartłomiej Płaczek",hash:"75ea6cdd241216c9db28aa734ab34446",volumeInSeries:9,fullTitle:"Data Acquisition - Recent Advances and Applications in Biomedical Engineering",editors:[{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9905",title:"Biometric Systems",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9905.jpg",slug:"biometric-systems",publishedDate:"February 10th 2021",editedByType:"Edited by",bookSignature:"Muhammad Sarfraz",hash:"c730560dd2e3837a03407b3a86b0ef2a",volumeInSeries:8,fullTitle:"Biometric Systems",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",institutionString:"Kuwait University",institution:{name:"Kuwait University",institutionURL:null,country:{name:"Kuwait"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8622",title:"Peptide Synthesis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8622.jpg",slug:"peptide-synthesis",publishedDate:"December 18th 2019",editedByType:"Edited by",bookSignature:"Jaya T. Varkey",hash:"de9fa48c5248dbfb581825b8c74f5623",volumeInSeries:0,fullTitle:"Peptide Synthesis",editors:[{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",institutionString:"St. Teresa’s College",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",slug:"computer-vision-in-dentistry",publishedDate:"September 18th 2019",editedByType:"Edited by",bookSignature:"Monika Elzbieta Machoy",hash:"1e9812cebd46ef9e28257f3e96547f6a",volumeInSeries:7,fullTitle:"Computer Vision in Dentistry",editors:[{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",editedByType:"Edited by",bookSignature:"Anna Nowinska",hash:"da2c90e8db647ead30504defce3fb5d3",volumeInSeries:6,fullTitle:"Novel Diagnostic Methods in Ophthalmology",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska",profilePictureURL:"https://mts.intechopen.com/storage/users/261466/images/system/261466.jpeg",institutionString:"Medical University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7437",title:"Nanomedicines",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7437.jpg",slug:"nanomedicines",publishedDate:"February 13th 2019",editedByType:"Edited by",bookSignature:"Muhammad Akhyar Farrukh",hash:"0e1f5f6258f074c533976c4f4d248568",volumeInSeries:5,fullTitle:"Nanomedicines",editors:[{id:"63182",title:"Dr.",name:"Muhammad Akhyar",middleName:null,surname:"Farrukh",slug:"muhammad-akhyar-farrukh",fullName:"Muhammad Akhyar Farrukh",profilePictureURL:"https://mts.intechopen.com/storage/users/63182/images/system/63182.png",institutionString:"Forman Christian College",institution:{name:"Forman Christian College",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",institutionString:"University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",value:9,count:1},{group:"subseries",caption:"Bioinspired Technology and Biomechanics",value:8,count:2},{group:"subseries",caption:"Bioinformatics and Medical Informatics",value:7,count:9}],publicationYearFilters:[{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:3}],authors:{paginationCount:617,paginationItems:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"8",type:"subseries",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{paginationCount:0,paginationItems:[]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/77202",hash:"",query:{},params:{id:"77202"},fullPath:"/chapters/77202",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()