\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1583",leadTitle:null,fullTitle:"Virtual Screening",title:"Virtual Screening",subtitle:null,reviewType:"peer-reviewed",abstract:"Pharmacophore modeling, QSAR analysis, CoMFA, CoMSIA, docking and molecular dynamics simulations, are currently implemented to varying degrees in virtual screening towards discovery of new bioactive hits. 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\r\n\r\n\tThe book also hopes to cover crises management and handling of communication with situational factors which cause sharp transformations on both sides economically, socially, technologically, psychologically, and so on. Theoretical and practical chapters contributing to the mentioned context are highly appreciated and welcomed.
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The expansion in the production of palm oil has created concerns about the effect of such an activity on local food security and rural livelihoods. It has also produced diverse effects on the growers and the environment. Though some studies suggest that farm households’ adoption of the crop contributes to alleviate poverty and improve households’ income and living standards [5, 7, 8, 9, 10], others have seen the activity as either promoting food security or aggravating the problem of food insecurity in some localities. For instance, [11, 12] have seen oil palm cultivation as an opportunity for fighting against rural poverty and food insecurity in several Southeast Asian countries, including in Indonesia and Malaysia.
However, [13] opined that the impact of oil palm expansion on food security is uncertain. This is possibly because, it is not always clear as to what extent, and under which prevailing circumstances, the production of the crop improves or compromises rural livelihoods and household food security [6, 14]. Some researchers [15] have argued that expansion of oil palm cultivation affects available land for food crop production and as a result food insecurity might be promoted. Others [16] have reasoned that waged employment in industrial crop plantations or smallholder oil palm cultivation can generate employment and income opportunities in rural areas of tropical region. Households can invest the obtained income to purchase food or improve farm productivity thereby increasing the yield of crops.
Available literature indicates that existing studies focused on the impact of oil palm expansion on some environmental and socio-economic issues rather than on food security; only few capture the interaction between oil palm cultivation and household food security. It is important to explore this area in order to understand the nature of the relationships between oil palm expansion in the tropics and household food security from a theoretical perspective and based on some empirical evidences. This paper, therefore, addresses the nexus between oil palm cultivation in the tropics and food security, and proffer solution on how land-use for oil palm can best be carried out to promote food security rather than food insecurity. It also aims to discuss identified several mechanisms through which oil palm production as an industrial crop interacts with the different pillars of food security – food availability, access, stability and utilization.
The Food and Agricultural Organization (FAO) projected that the agri-food sector would need to generate 50 percent more food by 2050 in order to meet the demand requirements, thereby making food security to be a global serious threat to millions of households in developing countries [17]. In the FAO’s 2019 Summit on Food Security and Nutrition in the world, several levels of food insecurity were identified: moderate food insecurity and severe food insecurity. Moderate food insecurity occurs when people face uncertainties about their ability to obtain food and thereby forced to reduce, at times during the year, the quantity and/or quality of food they consume due to lack of money or other resources. Severe food insecurity, on the other hand, affects a community or a nation when people have likely run out of food, experienced hunger and, at the most extreme, gone for days without eating, putting their health and wellbeing at serious risk.
Despite significant progress in recent decades by most countries in the oil palm producing countries of the tropics, hunger and nutritional deficiencies still constitute serious challenges in farm households. Indonesia, the leading oil palm growing country in the world, which was once self-sufficient in rice and sugar failed to keep up with demand in the face of rising population and there are doubts about the future stability in the country’s food system. This could be linked to the farm decisions of most oil palm farmers. Plantation farmers, for example, hardly cultivate food crops for their own consumption [5, 18]. Most plantation farmers heavily depend on agricultural cash income to purchase adequately diverse foods from such imperfect markets [18, 19], which consequently makes them vulnerable to substantial income and price shocks. Moreover, cultivating perennial and non-food commercial crops—that do not directly add to household dietary diversity through own consumption, are claimed to compete for resources (e.g., land) with other food crops that in turn negatively affects food availability and increase food prices [20]. This has significant implications in terms of food and nutrition security. According to the 2015 Global Hunger Index (GHI), Indonesia reduced its GHI score by about 25% and the rate was found to be higher in other oil palm growing nations like Thailand and Vietnam [21]. As a result, many of the nations have to resort to reliance on foreign imports to meet demand for key food products to ensure some level of food security. Concerning nutritional deficiencies, about 40% of the Indonesian population is affected by under-nutrition and micronutrient malnutrition, and majority of the affected group are farm households [22, 23]. It is not unlikely that similar situations may be prevalent in other oil palm growing regions of the tropical world.
For instance, [12] observed that the Jambi Province on the island of Sumatra, like other rural areas in South East Asia, has high levels of underweight and stunted children, poor household dietary diversity and pervasive micronutrient deficiency. The diets of farm households in the tropics in general are highly vulnerable to food prices and income shocks, most times due to global drop in prices of oil palm and rubber [24].
Food insecurity has grave consequences on people and the economy. Food insecurity could lead to stunting in children which is a significant health challenge. Between 2005 and 2015, the rate of stunting in children under the age of five in Indonesia increased from 28.6% to 36.4% According to the World Bank, children that experience stunting in their early development are less likely to graduate high school and are expected to earn ten percent less during their lifetime than their food secure peers.
In the Buvuma area of Uganda in East Africa food insecurity has been reported to be high. Poverty in the area made some farmers to sell their land cheaply to large oil palm companies. When they spent the money, several residents resorted to stealing food [25].
The farming of oil palm, which is not a food crop, contributes to food insecurity. Piesse [21] opined that oil palm production does not further food security and makes importation of food more likely. The researcher also opined that the competition for land from industry and housing has pushed many farmers out of the market thereby further reducing the ability of palm oil producing nations like Indonesia to produce their own food.
Most food-crop farmers are smallholders and face problems of economies of scale. This has made it difficult to increase food production to meet self-sufficiency targets. Other factors that affect hunger and malnutrition include economic slowdowns and downturns, world price fluctuations for countries dependent on production of primary commodities and the ability to trade in free and open markets which leads to unemployment affects income and ultimately access to food. This is mainly affecting countries dependent on primary commodity exports, in South America, Asia and some countries in Africa.
Promoting policies of oil palm nucleus estates that is not balanced with sustained programmes that gradually increase agricultural food productivity and distribution, have the potential to reduce food security. The experience of Indonesia is a case in point. Though the country has the potential to produce enough food to feed its population, but it is prevented from doing so due to some policy issues. Large tracts of its agricultural land have been developed for oil palm plantations, which, while commercially successful, do nothing to bolster food security.
The food distribution network is one of the largest barriers to food security and increased consumption of domestically produced food. Increased land use pressure from expanding industrial and urban areas makes it difficult to find new agricultural land that is close to transport infrastructure. This is found to be partly responsible for Indonesia’s poor domestic food production capacity. As the world’s largest archipelagic state, Indonesia faces unique challenges that complicate its food distribution system. Transporting food throughout its 6,000 or so inhabited islands is a particularly difficult undertaking that the government has long grappled with.
Demographic transition also poses a potential problem for food supply, especially in Indonesia. Piesse [21] noted that the Indonesian middle class is currently the fourth largest in the world, after the US, India and China. By 2030, about 20 million households are likely to belong to the middle class. As the middle class grows to occupy a larger portion of the population, a shift in food preferences is likely to follow. Middle class consumers are more likely to purchase higher-cost food products, such as meat, dairy and processed foods, which Indonesia will struggle to supply through domestic production alone. Indonesia will continue to rely on foreign imports to meet domestic demand in key food products such as rice and beef. This is likely going to be the situation in other oil palm producing countries in South East Asia, Sub-Saharan Africa and in South America.
Low commodity prices are also likely to drive food insecurity. A consistent slide in the price of commodities over time may lead to depreciation and devaluation of currencies resulting in domestic price increases, including food prices. This then affects the ability of households to buy food as the cost of food relative to their incomes increases.
Some researchers have expressed a direct relationship between palm oil production and food insecurity. For instance, [26], argues that palm oil production creates food insecurity in a direct way for local communities, especially rural and indigenous communities whenever government allocates to private plantation firms the land on which such communities depend on for their food and livelihood. Kimbowa [25] reported that Buvuma – Oil Palm Uganda Limited-BOPUL, a subsidiary of Oil Palm Uganda Limited and Bidco Uganda Limited in Kalangala arranged to acquire from the local communities 6, 500 hectares of land for oil palm cultivation while the out-growers of the companies will use 3, 500 hectares and this affected food production. Since their compensation in 2012, most of the residents have failed to secure alternative land for settlement and food production. In Nigeria, the Friends of the Earth also claimed that the allocation of agricultural land by the Cross River State Government to Wilmar International for the development of oil palm nucleus estates robbed the local communities of their land for arable crop production thereby promoting food insecurity in the affected communities.
Many plantation farmers are known to heavily depend on agricultural cash income to purchase adequately diverse foods [18, 19], thereby making them vulnerable to substantial income and price shocks. Furthermore, focusing on perennial and non-food commercial crops like oil palm that do not directly add to household dietary diversity through own consumption, is likely to encourage competition for land with other food crops which could negatively affect food availability and food prices [20].
A link between oil palm cultivation and food security has been established through some empirical studies. Using panel farm household data from Jambi province on the island of Sumatra, Indonesia, [24] examined the effects of oil palm adoption on dietary diversity, quantities of fruits and vegetables consumed calories, and food expenditure. Endogenous switching regression was applied to control for selection bias and to obtain counterfactual outcomes. Panel logit regression was also used to estimate the impact of oil palm adoption on dichotomous variables of household’s diets, indicating whether or not the diet met the minimum adequacy level of fruits and vegetables consumed as well as intake of calorie, iron, zinc, vitamin A, and the average of the three micronutrients. Regardless of the diet indicator, oil palm adoption was found to have statistically significant and positive effects, indicating that oil palm cultivation leads to higher food and micronutrient adequacy in general. On an average, the adoption of oil palm increases the probability of consuming fruits and vegetables by 33.6%, calorie adequacy by 38.6%, iron adequacy by 36.4%, zinc adequacy by 54.9%, vitamin A adequacy by 33.1%, and average adequacy of the three micronutrients by 35%. Together, with the results from the endogenous switching regression, it was deduced that oil palm adoption improves the diets of farm households in the tropics, whether they belong to the migrants or the local communities. Hence, the nutritional impact might justify why farm households in the tropical region are rapidly expanding oil palm cultivation. Moreover, several socioeconomic, farm, and demographic factors impact oil palm adoption and, at the same time, shape the diversity and adequacy of diets in those households. The study therefore supports the idea that adopting a perennial and non-food commercial crop like oil palm does not worsen dietary quality and diversity in farm household. Rather land-use change through oil palm adoption significantly improves the diets of farm households in the tropics.
An exploratory study was also carried out by [6] to assess the food security outcomes of smallholder-based oil palm and rubber production at the household level in the forest region of Guinea using six standardized metrics of food security. The selected metrics covered different aspects of food security related to diet diversity, perceptions of hunger and coping behaviors in the face of food scarcity. Households involved in industrial crop production were compared with households that only grow food crops under subsistence conditions, using statistical tools like Propensity Score Matching (PSM) and Endogenous Treatment Effect Regression (ETER). The results obtained are mixed. Both oil palm and rubber have significantly lower levels of diet diversity (Food Consumption Score, FCS) than subsistence farmers. However, industrial crop smallholders have lower levels of perception of hunger compared to subsistence farmers, with oil palm farmers having significantly better values than other groups. Both the PSM and ETER analyses suggest that involvement in industrial crop production decreases food security in terms of diet diversity, but when it comes to perception of hunger, the involvement of oil palm production improves food security. The results of the ETER regarding involvement in oil palm production and coping strategy index were statistically significant and therefore suggest that involvement in industrial crop production improves coping strategy index thereby enhancing food security. Overall, results show that oil palm and rubber smallholders perform better than subsistence farmers on metrics that capture perceptions of hunger and coping behaviors. However, involvement in oil palm and rubber production reduces the levels of food security metrics that use shorter time scales and measure food diversity. This implies that involvement in industrial crop production does not enhance consistently food security across all metrics. This could be explained to arise from the strong sense of security that steady and higher income provides across time (food stability), that outweighs the shortcomings on diet diversity (food utilization).
Furthermore, [27] established a causal relationship between oil palm cultivation and farmers’ household food security. Their study applied OLS and quantile regression models to household data in Indonesia to find the socio-economic factors that influence farmers’ food expenditure and calorie intake, and to estimate the effect of oil palm expansion on food security across quantiles. The study indicated a statistically significant influence of the income from oil palm expansion on calorie intake. The study further showed that expansions of oil palm cultivated area, resulting in more crop income, could lead farmers to consume more nutritious food, but the food share in the household budget decreases, which is consistent with Engel’s law. This is in consonant with the work of [5] who found that expansion of oil palm plantation by smallholder farmers positively affected nutritious food intake, particularly at the mid to upper tail of the expenditure distribution, implying that households in such categories spend their income to not only satisfy their basic calorie needs, but also consider the nutrient intake quantities in their daily diets.
In addressing how oil palm mitigates or promotes food insecurity, we want to look at palm oil and the pillars of food security: availability, access, utilization and stability. There is the availability of palm oil in the tropical world – through production, distribution, and exchange. The crop is efficiently produced in comparison with other vegetable oil. Less land and other resources are required per hectare to produce palm oil and associated by-products. There is an efficient distribution system of the product through storage, processing, transport, packaging and marketing in most oil palm producing countries which eliminates waste in the value chain. This tends to make palm oil available in the countries that consume the product. A system of exchange or cash economy exists to acquire oil palm products in all seasons, thereby promoting food security. However, climate change affects the crop productivity and thus its products availability [28].
Oil palm products are accessible. They are affordable and preferable to individuals and households because of the nutrients in them. Palm oil, for instance, contains beta carotene, a precursor of vitamin A and also contains equal proportion of saturated and unsaturated fatty acids [29]. Oil palm products are sold in units that almost every household can access. Since the crop has been found to lift many of its growers out of poverty [30, 31], the revenue obtained from the sale of oil palm products can be used to access other food items not produced in the environment. Based on the crop income per hectare of average oil palm smallholder farmer estimated to be $2,200 per annum in Nigeria [31] and $1,400 per annum in Indonesia [13], most families in oil palm producing communities are likely have enough financial resources to purchase food at prevailing prices or have sufficient land and other resources to grow their own food.
Oil palm farmers enjoy both direct access to food and financial resources. Many of them, especially those who integrate food crops into their farms, produce food using human and material resources available to them while some others purchase food produced elsewhere, with financial resources obtained from oil palm farming. However, access to food must be available in socially acceptable ways, without, for example, resorting to emergency food supplies, scavenging, stealing or other forms of coping strategies as experienced in the Kalangala region of Uganda where large oil palm companies stripped the locals of their agricultural land and were left without land to farm, though compensated. The amount paid could not keep them for long.
Palm oil and associated products are safe for human and livestock consumption, thereby promoting food utilization as a pillar of food security. With the Roundtable on Sustainable Palm Oil (RSPO), emphasizing certification of oil palm fields and operations, palm oil is safe for ingestion and the nutrients therein are enough to meet the physiological requirements of each individual consumer. The Malaysian Oil Palm Council is doing a lot of sensitization about nutrition and palm oil preparation which can affect oil palm products’ utilization and improve on food security.
Palm oil supply and prices can be considered to be relatively stable thereby making it possible to obtain the product supply over time. However, some forms of transitory palm oil food insecurity has existed in the past, thus making the products unavailable during certain periods of time. This has been due to drought resulting in crop failure and decreased food availability. There have also been cases of instability in markets resulting in food-price hikes causing transitory food insecurity. In virtually all oil palm producing nations, there are seasonal palm oil food insecurity resulting from the regular pattern of growing seasons of the crop. In Nigeria, for instance, the production level decreases during the rainy season which reduces the supply of the product to the market, thereby causing price rise. This limits the ability of some poor households to access the product or reduce the quantity bought.
There must be changes to the use of palm oil if the direct and indirect food security contributions of the crop are to be maintained. One of such measures is through private regulatory regimes such as voluntary certification as practised under the Roundtable on Sustainable Soy. So, palm oil sustainability should be effectively promoted in order that plantation areas can be certified by the Roundtable on Sustainable Palm Oil (RSPO) established since 2014 under the Swiss Civil Code. Oil palm producing nations should adopt the food security criteria developed by ZEF in 2015. It is expected to be integrated in sustainability standards for different crops. This is likely to ensure that human rights to food at local level is not violated and the nations buying palm oil are complying with good purchasing practices required by international bodies like UN, OECD and EU.
In order to further reduce the direct consequences of large oil palm plantations on food and livelihood security of rural and indigenous communities, the government of oil palm producing areas regions should allow only acquisition of reserve agricultural land or unused land instead of “grabbing lands” that are already in use by local communities. This is because acquiring forested land or forest dwellings or lands that are lived on and farmed by local communities for generations is likely to cause conflict and deprive the local people from using the area for arable crop production most beneficial to their livelihood.
Another way to promote food security while encouraging oil palm cultivation is through food crop integration into plantations [32]. With crop integration as practised in Malaysia, Nigeria and other oil palm growing nations, food availability is promoted. Crops integrated include – pineapple, groundnut, banana, soya bean, sugar cane, sorghum, sweet corn, sweet potato, green pea, etc. In some cases livestock are reared and made to graze under the palms as being practised by Siat in their plantations in Nigeria, Ghana, and Gabon. In Eastern part of Nigeria, the farmers carry out spacing of their oil palm trees, large enough to prevent the tress from forming canopy, to promote arable farming in the midst of the palms. In this way, the smallholder farmers have adequate supply of vegetable oil and food crops like cassava, yam, vegetables, sweet corn and cocoyam planted in between the oil palms. Thus, food security is promoted.
The paper examined the nexus between oil palm cultivation in the tropics and food security. It was established that food security is real in oil palm producing nations of the tropical world and has grave consequences on people and the economies. Some of the identified drivers of food insecurity include oil palm production policies that do not support food production, problem of economies of scale among smallholder farmers, increased land use pressure from expanding industrial and urban areas as well as poor food distribution system, among others. From theoretical perspective, some authors expressed a direct relationship between palm oil production and food insecurity. However, a number of empirical studies from different regions of the tropics indicated that palm oil production promote food security. In addressing how oil palm cultivation mitigates or promote food insecurity, we looked at palm oil and the pillars of food security – food availability, access, stability and utilization. For this to be achieved there must be changes to the use of palm oil through private regulatory regimes like the Roundtable on Sustainable Palm Oil (RSPO), acquisition of only reserve agricultural land or unused land instead of grabbing land already in use by local communities, and ensuring food crop integration into plantations. Thus, policy makers willing to maintain the tropical rain forest, expand cultivation of oil palm must consider the drivers of food insecurity and how expansion of oil palm cultivation, especially under smallholdings, promotes or negatively affects food security in the tropical region.
Vitamin D is a secosteroid hormone, which is known to be related to the regulation of the musculoskeletal system. It affects calcium and phosphate metabolism and is related to bone health. Recently, the extraskeletal effects of vitamin D are under intense research and have attracted the interest of the scientific community [1, 2, 3, 4, 5, 6]. In particular, the relationship of vitamin D with the immune system is in the focus of scientific evaluation [7, 8, 9]. In the chapter herein, the effects of vitamin D on the immune system will be discussed, and the relationship of vitamin D deficiency with the development of autoimmune diseases will be reviewed.
\nThe classic function of vitamin D is to enhance intestinal absorption of calcium by regulating several calcium transport proteins in the small intestine [4]. However, various cells express the vitamin D receptor (VDR) and the vitamin D activating enzyme 1-α-hydroxylase. Various cells of the immune system also express the VDR and harbor 1-α-hydroxylase [10, 11]. Thus, cells of the immune system respond to vitamin D and also activate vitamin D in a paracrine or autocrine fashion. The extra-renal 1-α-hydroxylase is not upregulated by PTH, and thus, production of 1,25(OH)2D3 is dependent on concentrations of the substrate 25(OH)D3, and it may be regulated by inflammatory signals, such as lipopolysaccharide and cytokines [12, 13]. Cells of the immune system, which express the VDR and harbor 1-α-hydroxylase, are macrophages, T cells, dendritic cells, monocytes, and B cells (Figure 1) [9]. Vitamin D is involved in the regulation of the innate immunity as it enhances the defense system of the organism against microbes and other pathogenic organisms, and it modulates the adaptive immune system through direct effects on T-cell activation and on the phenotype and function of antigen-presenting cells, particularly dendritic cells.
\nCells of the immune system regulated in part by vitamin D.
The innate immune system is a first line of defense against infection. Vitamin D is a regulator of the innate immune system [1, 14]. The first data on the effect of vitamin D on the innate immune system have been generated on the treatment of diseases caused by mycobacteria, such as tuberculosis and leprosy [15, 16, 17, 18]. Vitamin D has been used as a treatment of infections for more than 150 years. In 1849, Williams reported favorable results with the use of cod-liver-oil, an excellent source of vitamin D, in the treatment of patients with tuberculosis [19]. Fifty years later, Niels Finsen received the third Nobel Prize in Medicine for his description of using UV light, an effective method to increase vitamin D status, to treat lupus vulgaris, a cutaneous form of tuberculosis [20, 21]. Alfred Windaus contributed to the discovery of the chemical structure of vitamin D2 and vitamin D3 found in cod-liver-oil and received the Nobel prize [22, 23, 24]. Thereafter, several groups used vitamin D2 and D3 as a treatment for tuberculosis [22, 25]. Rook et al. [26] demonstrated in the 1980s that 1,25(OH)2D3 inhibited the proliferation of
Data regarding other infections also exist. Thus, children with low vitamin D status may be more prone to urinary tract infections due to low production of cathelicidin and defensin β2 [38, 39]. Also, adults with asthma may be less prone to infection after treatment with vitamin D due to increased production of cathelidicin and modulation of inflammatory cytokines [40, 41]. Low levels of vitamin D may be related to chronic obstructive pulmonary disease severity [42]. Vitamin D may increase resistance to HIV infection. Low levels of vitamin D have been associated with disease progression and mortality [43]. The ability of the immune cells to hydroxylate 25(OH)D3 locally suggests that in patients with infections, it may be better to administer 25(OH)D3 rather than hydroxylated metabolites to allow for local production and the feedback system to function.
\nThe natural history of autoimmunity remains largely unknown. However, the theory is that both genetic susceptibility and environmental factors play a role in the development of clinical autoimmune disease. Vitamin D has known immunomodulatory effects on a wide range of immune cells, including T and dendritic cells [44, 45]. Each of these immune cells expresses VDR and produces the enzymes 1-α-hydroxylase and 24-hydroxylase and is therefore capable of locally producing active 1,25(OH)2D3 [46, 47, 48, 49]. Activation of CD4+ T cells results in a significant increase in VDR expression enabling regulation of many genes responsive to 1,25(OH)2D3 [50]. 1,25(OH)2D3 suppresses T-cell receptor induced T cell proliferation and changes their cytokine expression. The overall shift is away from T helper Th1 phenotype toward a more tolerogenic Th2 response [51, 52, 53]. Vitamin D appears to directly inhibit Th1 cells and may additionally modulate a skewing toward a Th2 response [54]. Th17 cells are a subset of CD4+ T cells involved in organ-specific autoimmunity playing a role in maintaining inflammation, which can lead to tissue damage. 1,25(OH)2D3 suppresses autoimmunity and tissue destruction by inhibiting the Th17 response at several levels [55, 56]. Altogether, the evidence suggests an important role for vitamin D in influencing T-cell responses and in tempering inflammation and tissue damage.
\nVitamin D appears to have a direct effect on B cells and inhibits immunoglobulin production [57]. Additionally, differentiation of B cells is interrupted when exposed to 1,25(OH)2D3. 1,25(OH)2D3 also has effects on dendritic cells. Dendritic cells have important functions in maintaining both protective immunity and self-tolerance [58, 59]. Physiologic levels of 1,25(OH)2D3 inhibit maturation of dendritic cells and maintain an immature and tolerogenic phenotype with inhibition of activation markers such as MHC class II, CD40, and others and upregulation of inhibitory molecules [60, 61]. Thus, it appears that the maturational state of dendritic cells can be modulated by 1,25(OH)2D3, making it possible that the vitamin D status of an individual is likely to have important immunologic consequences.
\nThere are several animal models of autoimmunity, in which disease could either be prevented or ameliorated with the administration of either 1,25(OH)2D3 or one of its analogues. These animal models are models of autoimmune encephalomyelitis, collagen-induced arthritis, type 1 diabetes mellitus, inflammatory bowel disease, autoimmune uveitis, and lupus [44, 56, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76]. These studies show that treatment with active vitamin D is effective in modulating immune function and ameliorating autoimmune disease. Vitamin D deficiency is a risk factor for the development of some autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes mellitus type 1, multiples sclerosis, inflammatory bowel disease, and Hashimoto’s thyroiditis [49, 69, 74, 77, 78, 79, 80, 81, 82, 83, 84, 85] (Figure 2). Additionally, vitamin D deficiency has been observed in patients with systemic sclerosis [86].
\nAutoimmune diseases related to vitamin D deficiency.
A meta-analysis showed that low vitamin D intake is associated with the development of RA [87]. Thereafter, several studies performed in various areas all over the world showed that vitamin D deficiency is observed in patients with RA and that vitamin D deficiency is associated with disease activity [78, 82, 83, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97]. A meta-analysis of the good quality studies performed regarding the association between vitamin D deficiency and RA showed that vitamin D deficiency is observed in RA patients significantly more than in a control group and that vitamin D levels are inversely correlated with disease activity, meaning that low vitamin D levels are associated with high-disease activity [98]. Moreover, an association has been shown between VDR polymorphism and RA. Specifically, the Fokl F allele of the VDR may be a risk factor for the development of RA [99]. Further studies are needed to unravel the exact association between vitamin D deficiency and RA and to determine the best method of vitamin D supplementation and whether it may be used for the prevention of RA or for the best management of the disease [77, 100]. In addition, it has been proposed that vitamin D may contribute to the management of pain in RA and may be used along with TNF-α inhibitors in RA treatment [77, 101].
\nIn SLE, the inflammatory milieu drives the development of T cells into proinflammatory pathways, defective function of Tregs, and survival and activation of B cells, which produce autoantibodies [78, 81]. Patients with systemic lupus erythematosus have lower 25(OH)D3 levels compared to controls, suggesting that vitamin D deficiency may be a risk factor for SLE [81, 84, 102, 103, 104, 105, 106, 107]. The majority of studies have also found higher SLE disease activity associated with lower levels of 25(OH)D3 [84, 103]. As patients with SLE have often photosensitivity and are advised to avoid direct sun exposure, detecting vitamin D deficiency and replacing 25(OH)D3 with oral supplementation is critical and may impact disease activity [108].
\nType 1 diabetes mellitus is one of the most prevalent chronic diseases with onset in childhood and is the result of immune-mediated destruction of pancreatic insulin producing β cells. There appears to be a geographic variation in incidence following a gradient in latitude, which is the inverse of the global distribution of ultraviolet B irradiation, critical for the production of vitamin D within the skin [109]. Studies have shown higher incidence of vitamin D deficiency in patients with type 1 diabetes [110, 111, 112, 113]. One environmental factor thought to be protective against the development of type 1 diabetes mellitus is early supplementation with vitamin D [114]. A number of large case control studies showed that the risk of type 1 diabetes mellitus was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented [115, 116, 117]. Additionally, a lower incidence of type 1 diabetes was observed in infants born to mothers who were administered cod liver oil during pregnancy [118]. A birth cohort study in Finland, now more than 50 years ago, evaluated the effects of vitamin D supplementation on rickets and the development of type 1 diabetes mellitus [85]. All women due to give birth in 1966 were enrolled. There was an 80% reduction in the risk for type 1 diabetes mellitus in children having received >2000 IU vitamin D/day compared to those receiving less or not receiving supplementation with vitamin D. Evidence from both human and animal studies shows that vitamin D may be protective as far as the development of type 1 diabetes mellitus is concerned [68, 71, 76]. Thus, the administration of vitamin D may prevent diabetes mellitus type 1; however, once the destruction of pancreatic beta cells has taken place, it will not act therapeutically to reverse diabetes mellitus type 1.
\nMultiple sclerosis is characterized by inflammation, demyelination, axonal or neuronal loss, and astrocytic gliosis in the central nervous system, which can result in disability. Epidemiological studies have suggested that vitamin D insufficiency may contribute to the risk of multiple sclerosis [62, 63, 75, 119, 120]. Moreover, several genetic studies in multiple sclerosis patients have shown that diverse abnormalities in vitamin D metabolism are related to the risk of the disease. It appears that vitamin D deficiency may interact with genetic and environmental protective and risk factors, such as the allele HLA BRB1*1501, infections, obesity, smoking, and sexual hormones and may modulate the risk of the disease [63, 74, 80]. Thus, vitamin D deficiency may be a risk modulating factor for the development of multiple sclerosis. Vitamin D acts as an immunomodulatory factor affecting T and B lymphocytes, and it may exert neuroprotector and neurotrophic actions within the central nervous system. Several studies have shown that vitamin D supplementation exerts multiple beneficial immunomodulatory effects in multiple sclerosis [121, 122, 123, 124]. On the contrary, a Cochrane review states that there appears to be no benefit from vitamin D supplementation in patients with multiple sclerosis; however, the level of evidence is very low [125]. Nevertheless, it should be noted that robust statistical models used in association studies have already predicted a favorable vitamin D effect reducing relapses by 50–70% [121]. There is little doubt that vitamin D exerts a beneficial action on multiple sclerosis, the inflammatory component in particular, less so the degenerative. Until more information becomes available, vitamin D supplementation of multiple sclerosis patients, using a moderate physiological dose essentially correcting their vitamin insufficiency, is recommended.
\nVitamin D deficiency has been observed in patients with inflammatory bowel disease, Crohn’s disease, and ulcerative colitis [126]. It was found to be related to disease activity in Crohn’s disease and ulcerative colitis. Vitamin D supports the integrity of the intestinal barrier and is related to microbiota homeostasis in this cohort of patients [127, 128]. Thus, vitamin D may contribute to the prevention of inflammatory bowel disease by supporting the integrity of the intestinal barrier, contributing to bacterial homeostasis and ameliorating disease progression via anti-inflammatory action. Vitamin D deficiency in inflammatory bowel disease is aggravated by decreased absorption of the vitamin via the gastrointestinal tract [128].
\nStudies have observed an association between autoimmune Hashimoto’s thyroiditis and low vitamin D levels [79, 129]. These studies have not observed low vitamin D levels in patients with Graves’ disease. A meta-analysis of 26 observational studies confirmed an association between vitamin D deficiency and autoimmune Hashimoto’s thyroiditis [130]. The aforementioned meta-analysis found that although there was heterogeneity between the results of the various studies performed all over the globe, studies had similar results in populations from different countries and also in populations in different age ranges, in particular pediatric and adult populations.
\nSystemic sclerosis is a chronic, inflammatory, fibrotic disorder thought to be related to autoimmune etiology. Vitamin D deficiency has been observed in patients with systemic sclerosis [86, 131], especially in patients with the diffuse type of the disease [131].
\nThe molecule used to assess vitamin D sufficiency in a population is 25(OH)D3 [9]. It appears that vitamin D has physiologic effects beyond those related to bone physiology and mineral homeostasis. It may be that the alarming prevalence of vitamin D deficiency observed all over the globe may be contributing to the development of autoimmune diseases. Based on bone-related biomarkers such as intact parathyroid hormone, calcium absorption, and bone mineral density, maintaining a 25(OH)D3 level of at least 32 ng/ml appears sufficient.
\nIt appears that vitamin D is a potent immunomodulator. It has multiple and diverse effects on the immune system. In particular, it potentiates the innate immune response enhancing the production of cathelicidin from human macrophages, monocytes, and keratinocytes, thus enhancing and potentiating the immune response against external pathogens. It affects the adaptive immune response shifting the phenotype of the adaptive immune response toward a more tolerogenic phenotype. Vitamin D deficiency is related to various autoimmune disorders. Vitamin D deficiency appears to be related to the development of RA and correlates with disease severity. Vitamin D deficiency is observed in patients with SLE. It was found to be related to disease severity and activity in some but not all studies. Vitamin D deficiency is observed in patients with multiple sclerosis, and vitamin D administration may ameliorate disease severity. Vitamin D deficiency is also observed in patients with inflammatory bowel disease, Crohn’s disease, and ulcerative colitis, and it is related to disease activity. Vitamin D contributes to the integrity of the intestinal barrier and bacterial homeostasis. In addition, vitamin D absorption is decreased making supplementation important. Vitamin D deficiency is also observed in patients with autoimmune Hashimoto’s thyroiditis. Vitamin D deficiency is found in patients with systemic sclerosis, especially the diffuse form of the disease. It appears that optimal levels of vitamin D are important for immune function and for the prevention of autoimmunity in the human organism.
\nThe authors declare no conflict of interest.
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During the discussion, a wide number of examples and methodologies are exposed according to different tools and sensors, including the description of a recent method of terrain assessment using normal vectors analysis. Indeed, normal vectors has demonstrated great potentialities in the field of terrain irregularity assessment in both on‐road and off‐road environments.",book:{id:"5263",slug:"robot-control",title:"Robot Control",fullTitle:"Robot Control"},signatures:"Mauro Bellone",authors:[{id:"158265",title:"Dr.",name:"Mauro",middleName:null,surname:"Bellone",slug:"mauro-bellone",fullName:"Mauro Bellone"}]},{id:"51960",title:"Induced Force Hovering of Spherical Robot by Under-Actuated Control of Dual Rotor",slug:"induced-force-hovering-of-spherical-robot-by-under-actuated-control-of-dual-rotor",totalDownloads:1776,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"This chapter discusses the design and modelling of a spherical flying robot. The main objective is to control its hovering and omnidirectional mobility by controlling the air mass differential pressure between two asynchronous coaxial rotors that are aligned collinearly. The spherical robot design has embedded a gyroscopic mechanism of three rings that allow the rotors’ under-actuated mobility with 3DOF. The main objective of this study is to maintain the thrust force with nearly vertical direction. The change in pressure between rotors allows to vary the rotors’ tilt and pitch. The system uses special design propellers to improve the laminar air mass flux. A nonlinear fitting model automatically calibrates the rotors’ angular speed as a function of digital values. This model is the functional form that represents the reference input to control the rotors’ speed, validated by three types controllers: P, PI, and PID. The robot’s thrust and induced forces and flight mechanics are proposed and analysed. The simulation results show the feasibility of the approach.",book:{id:"5263",slug:"robot-control",title:"Robot Control",fullTitle:"Robot Control"},signatures:"G. Santos-Medina, K.Y. Heras-Gaytán, E.A. Martínez-García, R.\nTorres-Córdoba and V. Carrillo-Saucedo",authors:[{id:"84958",title:"Dr.",name:"Edgar A.",middleName:"Alonso",surname:"Martínez García",slug:"edgar-a.-martinez-garcia",fullName:"Edgar A. Martínez García"},{id:"185784",title:"B.Sc.",name:"Gerson",middleName:null,surname:"Santos-Medina",slug:"gerson-santos-medina",fullName:"Gerson Santos-Medina"},{id:"185785",title:"BSc.",name:"Karla",middleName:null,surname:"Heras-Gaytan",slug:"karla-heras-gaytan",fullName:"Karla Heras-Gaytan"},{id:"185786",title:"Dr.",name:"Rafael",middleName:null,surname:"Torres-Córdoba",slug:"rafael-torres-cordoba",fullName:"Rafael Torres-Córdoba"},{id:"185787",title:"Dr.",name:"Victor",middleName:null,surname:"Carrillo-Saucedo",slug:"victor-carrillo-saucedo",fullName:"Victor Carrillo-Saucedo"}]},{id:"51927",title:"Adaptive Steering and Trajectory Control of Wheeled Mobile Robots for Autonomous Navigation",slug:"adaptive-steering-and-trajectory-control-of-wheeled-mobile-robots-for-autonomous-navigation",totalDownloads:1973,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter presents a new reactive navigation algorithm for a wheeled mobile robot (WMR) with a differential drive mechanism moving in unknown environments [1]. The mobile robot is controlled to travel to a predefined goal position safely and efficiently without any prior map of the environment. The navigation is achieved by modulating the steering angle and turning radius. To avoid obstacles while seeking the goal position, the dimensions and shape of the robot are incorporated to determine the set of all possible collision-free steering angles. The algorithm then selects the optimum steering angle candidate to contour the obstacle. Simulation and experimental results on a WMR prototype are used to validate the proposed algorithms.",book:{id:"5263",slug:"robot-control",title:"Robot Control",fullTitle:"Robot Control"},signatures:"Mariam Al-Sagban and Rached Dhaouadi",authors:[{id:"183057",title:"M.Sc.",name:"Mariam",middleName:null,surname:"Al-Sagban",slug:"mariam-al-sagban",fullName:"Mariam Al-Sagban"}]},{id:"10584",title:"Visual Odometry and Mapping for Underwater Autonomous Vehicles",slug:"visual-odometry-and-mapping-for-underwater-autonomous-vehicles",totalDownloads:3024,totalCrossrefCites:2,totalDimensionsCites:9,abstract:null,book:{id:"3711",slug:"robot-localization-and-map-building",title:"Robot Localization and Map Building",fullTitle:"Robot Localization and Map Building"},signatures:"Silvia Botelho, Gabriel Oliveira, Paulo Drews, Monica Figueiredo and Celina Haffele",authors:null}],onlineFirstChaptersFilter:{topicId:"1305",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). 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He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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In recent years, emerging technologies such as multi-omics, high-throughput technologies, and genome editing tools could assist plant physiologists in unraveling molecular mechanisms in specific critical pathways. The global picture of physiological processes in plants needs to be investigated continually to increase our knowledge, and the resulting technologies will benefit sustainable agriculture.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11409,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:null,institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. 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