More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\n
Additionally, each book published by IntechOpen contains original content and research findings.
\\n\\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\n
Simba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\n
IntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\n
Since the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\n
Additionally, each book published by IntechOpen contains original content and research findings.
\n\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n
\n\n
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In brachytherapy each treatment is best fitted by physician's' hand, and appropriate arrangement and selection of radiation sources facilitates the fitting. This book is full of essences to make a breakthrough in radiation oncology by brachytherapy. I hope this book will encourage all people related.\nContents 1: problem of currently popular dosimetric method; 2: Monte Carlo dose simulation of ruthenim-106/rhodium-106 eyes applicators; 3. Progress in Californium-252 neutron brachytherapy; 4. Clinical aspect of endobronchial brachytherapy in central airway tumor obstruction; 5. Review from principle and techniques of Iodine-125 production at nuclear reactor plant to their clinical practive in prostate cancer treatment; 6. Stereotactic Brachytherapy for Brain Tumors using Iodine-125 seed; 7. 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\r\n\tMedicinal herbs and culinary spices are very important sources of bioactive compounds for different kinds of industries. They accompany a person's life from birth to grave almost every day, in various forms is, served to our table as a part of the food. Many plants are necessary for technical and bioenergetic purposes, and a large group of plants is used in medicine, pharmacy, cosmetics as well as in folk medicine, and gastronomy. Approximately one thousand types of medicinal plants grow in Europe – about 800 are used in folk medicine, more than 300 in European officinal medicine. Nowadays, people have started to be more interesting in this kind of plant due to the benefits. The style "return back to tradition" is one of the more popular trends. The aim of this book is brought to information about medicinal herbs and spices – botany characteristics, chemical components, and the possibility of use in different kinds of industries.
",isbn:"978-1-83768-475-5",printIsbn:"978-1-83768-474-8",pdfIsbn:"978-1-83768-476-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"dbbc40b4b09244389b52ca80dcc10768",bookSignature:"Dr. Eva Ivanišová",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12143.jpg",keywords:"Medicinal Herbs, Antioxidant Activity, Polyphenols, Flavonoids, Phenolic Acids, Bioactive Compounds, Herbals, Health Benefits, Folk Medicine, Gastronomy, Plants, Traditional Culture",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 24th 2022",dateEndSecondStepPublish:"July 22nd 2022",dateEndThirdStepPublish:"September 20th 2022",dateEndFourthStepPublish:"December 9th 2022",dateEndFifthStepPublish:"February 7th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"21 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Eva Ivanišová is an assistant professor, with research focused on food technology, especially bioactive compounds of plant raw materials and foodstuffs. She is the author/co-author of 453 publications and 2 patents.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"352448",title:"Dr.",name:"Eva",middleName:null,surname:"Ivanišová",slug:"eva-ivanisova",fullName:"Eva Ivanišová",profilePictureURL:"https://mts.intechopen.com/storage/users/352448/images/system/352448.jpg",biography:"Ing. Eva Ivanišová, Ph.D. assistant professor at the Institute of Food Sciences, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture Nitra, head of Laboratory of Fats and Oils in Research Centrum AgroBioTech in SUA Nitra. She solved resp. it addresses 14 research home projects but also educational and 2 international projects. She is the author, resp. co-author of 453 publications. Her works, especially in foreign journals, are a guarantee of international acceptance. Awards: 2011 – Rector's Award for best student; 2015 and 2019, 2020 – Dean's Award for the Best of publication activity. Under her leadership, 29 Bachelors and 55 diplomats successfully defended their work. She is a member of the international network AgroBioNet; Member of EFSA; CASEE; Member of Evaluation Commission for Start-up projects EIT Food Hub; Member of Examining Commissions for State Examinations; member of scientific committees of international conferences \"Meeting of Young Researches from V4 Countries\", University of Rzeszow, Poland. She is a head of graduation commission in secondary school in Nitra (SOŠ Slančíková Nitra). She is a reviewer of the journals – Natural Product Research (IF 1.999), Journal of Food Science (IF 2.478), Acta Scientiarum Polonorum Technologia Alimentaria, Journal of Agricultural Science and Technology, BMC Complementary Medicine and Therapies (IF 2.833), Food Chemistry (IF 6.306), Journal of Food Science and Technology (IF 1.849), SN Applied Sciences, RSC Advances (IF 3.070), PLoS One (2.740), Open Life Sciences (IF 0.690), Journal of Microbiology, Biotechnology and Food Sciences, Journal of Central European Agriculture et al.",institutionString:"Slovak University of Agriculture",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Slovak University of Agriculture",institutionURL:null,country:{name:"Slovakia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"478197",firstName:"Veronika",lastName:"Radosavac",middleName:null,title:"Dr.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"veronika@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10359",title:"Landraces",subtitle:"Traditional Variety and Natural Breed",isOpenForSubmission:!1,hash:"0600836fb2c422f7b624363d1e854f68",slug:"landraces-traditional-variety-and-natural-breed",bookSignature:"Amr Elkelish",coverURL:"https://cdn.intechopen.com/books/images_new/10359.jpg",editedByType:"Edited by",editors:[{id:"231337",title:"Dr.",name:"Amr",surname:"Elkelish",slug:"amr-elkelish",fullName:"Amr Elkelish"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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1. Introduction
We are interested, in this chapter, in adaptive system control of a class of single-input single-output (SISO) non-linear systems using neural network. In fact, this system control is a very general approach to adaptive control since one can combine in principle any parameter estimation scheme with any control strategy. In addition, its architecture is based on two neural network blocks corresponding to the system controller and the model identification of the dynamic behavior of the system [1, 2].
The use of artificial neural network (ANN) for identification, diagnosis, modeling and control has generated a lot of interest for quite some time now, because they have proved to be excellent function approximators, mapping any function to an arbitrary degree of accuracy, coupled with their ability for generalization, self-organization and self-learning [3].
Many architectures of neural networks are used. Among them, the most common and the most popular architecture is the multilayered perceptron, implemented with the standardized backpropagation algorithm. If the initial set of weights is not selected properly, this algorithm, employing a gradient descent search technique is seriously prone to getting trapped in local optimum solutions. However, the calculations could slowly occurred and may even overflow or fluctuate between the optima. These limitations encouraged researchers to look for more powerful optimizations techniques that can help reach the optimal solution in an improved fashion, guarantee the convergence of control system and increase the learning speed [3].
A lot of optimization techniques of neural network are widely used. Among them, particle swarm optimization (PSO), the subject of this chapter, studied in different papers like in [3], and originates from the behavioral simulation of fish schooling and bird flocking. The conceptual model, at some point in the evolution of the algorithm, was an optimizer following which a number of parameters extraneous to optimization were eliminated leading to the basic PSO algorithm [3].
This technique is used in many applications of neural network optimization like identification, control and modeling. For instance, in [4], the authors used the PSO based neural network optimization for prediction of diameter errors in a boring machine. In their work, they established an improvement in the quality of optimization of the neural networks and error compensations with the use of the PSO algorithm, which achieves a better machining precision with fewer numbers of iterations.
The PSO algorithm is proposed to get optimal the parameters of ANN. This algorithm is well used because it has convergent result and not require many iterations, so in relative calculation relative quick. PSO is a population-based approach, which uses the swarm intelligence generated by the cooperation and competition between the particles in a swarm. It has been emerged successfully to a wide variety of search and optimization problems.
For example, in [5], the authors compared the performance of the PSO technique with other EAs for both continuous and discrete optimization problems in terms of processing time, convergence speed, and quality of the results. In addition, in [6], the authors proposed a PSO learning algorithm that self-generates radial basis function neural network (RBFN) to deal with three non-linear problems. This proposed PSO allows a high accuracy within a short training time when determining RBFN with small number of radial basis functions. Then, in [7], a PSO algorithm was developed by the authors to find the optimum process parameters which satisfy given limit, tool wear and surface roughness values and maximize the productivity at the same time. Also, in [8], the authors described an evolutionary algorithm for evolving the ANN which was based on the PSO technique. Both the architecture and the weights of the ANN were adaptively adjusted according to the quality of the neural network until the best architecture or a terminating criterion was reached. Moreover, the performance of the basic PSO algorithm with the constriction PSO on some test functions of different dimensions was compared by [9] and they found that the use of constriction PSO with mutation provided significant improvement in certain cases.
Further, in [10], it is presented an improved PSO algorithm for neural network training employing a population diversity method to avoid premature convergence. Furthermore, in [11], the authors used the PSO technique to optimize the grinding process parameters such as wheel and workpiece speed, depth and lead of dressing, etc. subjected to suitable constraints with the objective of minimizing the production cost and obtaining the finest possible surface finish. As well as, by comparing the PSO algorithm results with genetic algorithms and quadratic programming techniques, the PSO algorithm gives the global optimum solution with the objective to obtain minimum cost of manufacturing, [12]. Equally, in [13], the authors applied ANN - PSO approach for selection of optimum process parameters for minimizing burr size in drilling process. Besides that, the PSO algorithm was applied for optimization of multi objective problem in tile manufacturing process [14] and also for machinery fault detection [15]. Finally, in [16] the authors used PSO to tune the radial basis function networks for modeling of MIG welding process.
The PSO is well used in control system, for instance, in [17], the parameters of PID are tuned by ANN where their weights are optimized using PSO method to avoid any local minima/maxima in its searching procedure. In [18], the authors proposed a design of decentralized load-frequency controller for interconnected power systems with ac-dc parallel using PSO algorithm. The experiment result illustrated that their method have rapid dynamic response ability. In [19], the PSO algorithm is implemented to optimize the own five parameters of PIλDδ controller via El-Khazali’s approach in order to minimize several error functions satisfying some step response specifications such as the set of time domain and frequency domain constraints; overshoot, rise time and settling time. In [20], a comparative analysis of PSO algorithms is carried out, where two PSO algorithms, namely PSO with linearly decreasing inertia weight (LDW-PSO), and PSO algorithm with constriction factor approach (CFA-PSO), are independently tested for different PID structures.
In this chapter, a comparison of the performance of the PSO optimized neural network with the standard back-propagation is presented for the adaptive indirect control of nonlinear time-varying discrete system.
The present chapter is organized as follows. After this introduction, section 2 reviews the problem statement. Furthermore, in section 3 the neural network optimization methods are shown. In Section 4, tuning neural network controller using classical approach is presented. However, the section 5 details tuning neural network controller using PSO approach. An example of nonlinear system is studied, in section 6, to illustrate the proposed efficiency of the method. Section 7 gives the conclusion of this chapter.
2. Problem statement
The indirect adaptive control that is used, in this chapter, is composed of two blocks: a block of neural network model and a block of control system. The proposed control system is a neural network controller. At the simulation, it is assume that the neural network controller parameter’s depending of the model parameter’s as given in Figure 1.
Figure 1.
The architecture of indirect neural control.
In this architecture of indirect control, rk is the desired value, uk is the control law from the controller, yk is the output of the nonlinear system, yrk is the output of the neural network model, ek is the identification error, êck is the estimated tracking error, eck is the tracking error and k is the discrete time.
The aim of this chapter is to find a control law uk to the nonlinear system, given by the Eq. (1), based on the tuning neural network controller’s parameters in order that the system output yk tracks, where possible, the desired value rk.
yk+1=fyk…yk−nyuk…uk−nuE1
f. is the nonlinear function mapping specified by the model, ny and nu are the number of past output and input samples respectively required for prediction.
In this structure, the neural network controller and the neural network model must be updated at the same time. But, it is a difficult task to have a neural identifier learn the system fast enough to adapt to varying parameters. Therefore, the neural controller is ineffective on variations of the system parameters. In this chapter, to solve this problem we propose a fast learning algorithm based on a particle swarm optimization approach.
3. Neural network optimization methods
3.1 Gradient back-propagation algorithm
An Artificial Neural Networks (ANN) with randomly initialized weights usually shows poor results. That’s why the most interesting characteristic of a neural network is its ability to learn, in other words, to adjust the weights of its connections according to the training data so that after training phase the faculty of generalization is obtained. This formulation turns the problem of learning into a problem of optimization.
In general, optimizing a system’s parameters for a given task requires defining a metric that captures the inadequacy of the system for that task. This measure is called the cost function. Using an optimization algorithm, it is about finding the optimal parameters of the neural model that minimizes the cost.
For this kind of problem, there are two important classes of cost minimization search algorithms. Classical or gradient algorithms in which the central concept is that of direction of descent, are based on the derivatives of the cost function and any constraints, and advantageously made use of the specific information provided by the derivatives of different orders of these functions.
The alternative to these approaches is the use of meta-heuristics or heuristics such as genetic, stochastic, or evolutionary algorithms. Despite the notable advantage of not assuming regularity and their ability to locate the global minimum, these algorithms are strongly penalized by the relatively low convergence speeds and long computation times.
In the case of algorithms using the information provided by the derivatives of the functions defining the problem, each iteration comprises two main phases: the search for a direction of descent dk and the determination of a step of descent η given by the following formula:
xk+1=xk+ηdkE2
The difference between these algorithms is manifested in the way these two steps are performed.
There are also three classes for such algorithms according to the strategy used to calculate the direction of descent:
gradient algorithms such as:
dk=−∇fxkE3
algorithms based on Newton’s method in which the direction of descent is the solution of the system
∇2fxkdk=∇fxkE4
the algorithms of the quasi-Newton type, in which an approximation Hk of the Hessian matrix evaluated in the iterates is built, the direction being then, as for the method of Newton, the solution of the linear system
Hkdk=∇fxkE5
The gradient back-propagation algorithm is the most widely used for weight adaptation, the goal of which is to find the appropriate combination of connection weights that minimizes the error function E defined by:
E=12∑kyk−yrk2E6
yk and yrk being, respectively, the desired output and the actual output of the k neuron for a given input vector.
This procedure is based on an extension of the Delta rule which involves a gradient descent and which consists in propagating an observation of the input of the neural network through the neural layer, to obtain the output values.
Compared to the desired outputs, the resulting errors allow the weights of the output neurons to be adjusted. Without the presence of the hidden layer, the knowledge of these errors allows a direct calculation of the gradient and makes the adjustment of the weights of these single neurons, easy as shown by the Delta rule. So for a network with hidden layers, ignoring the desired outputs of the hidden neurons, it thus remains impossible to know the errors of these neurons. So, as it is, this process cannot be used for weight adjustment of hidden neurons. The intuition which solves this difficulty and which gave rise to back-propagation was as follows: the activity of a neuron is linked to neurons of the preceding layer. Thus, the error of an output neuron is due to the hidden neurons of the previous layer in proportion to their influence; therefore according to their activation and the weights that connect the hidden neurons to the output neuron. Therefore, we seek to obtain the contributions of the L hidden neurons which gave the error of the output neuron k.
The back-propagation procedure consists in propagating the error gradient (error produced during the propagation of an input vector) in the network. In this phase, the propagation of an output neuron’s error starts from the output layer to the hidden neurons.
It is therefore sufficient to retrace the original activation path backwards, starting from the errors of the output neurons, to obtain the error of all the neurons in the network. Once the corresponding error for each neuron is known, the weight adaptation relationships can be obtained.
3.2 Second order optimization method
Another class of methods, more sophisticated than the previous one, is based on second order algorithms, based on Newton’s method which adapts the weights according to the following relation:
Δw=−H−1∇EE7
where the element Hij of the Hessian matrix H relates to the second partial derivatives of the cost function, compared to the weights. The elements of this matrix are defined by
Hij=∂2E∂wi∂wjE8
Like gradient-only methods, second-order methods determine the gradient by the back-propagation algorithm and generally approximate the Hessian matrix or its inverse, since the cost of its computation may quickly become prohibitive.
This type of method localizes, in a single iteration, the minimum of a quadratic empirical error criterion and requires several iterations when this criterion is not ideally quadratic.
In practice, the convergence of the corresponding algorithm towards an optimal solution is rapid so that a good number of error hyper-surfaces present a quadratic curvature in the immediate vicinity of the minima. This method nevertheless remains subject, when the error hyper-surfaces are complex, to convergence towards non-minimal solution points for which the gradient of the empirical error criterion is canceled out at the inflection points or at the saddle points. In addition, there are the possibilities of divergence of the algorithm when the Hessian matrix is not positive definite.
The evaluation and memorization of the inverse Hessian matrix, on which the second-order methods are based, is, however, a major handicap in the context of learning large networks.
But, the main drawback lies in the calculation of the second derivatives of E which is most often expensive and very difficult to carry out. A certain number of algorithms propose to get around this difficulty by using approximations of the Hessian matrix.
This approximation, at the basis of Gauss-Newton or Levenberg–Marquardt algorithms, is widely used in the identification of rheological parameters. This method is adapted especially for the problems of small dimensions since the computation of the Hessian matrix is easy. Whereas if the problem presents a large number of variables, it is generally advised to couple it with the conjugate gradient method or a Quasi-Newton method. Or, when the relative improvement in the objective function becomes too low, we automatically switch to the conjugate gradient method.
The Levenberg–Marquardt method, Marquardt method, another second-order method, very close to the Newton method described previously, in fact offers an interesting alternative by adjusting the weights as following:
Δwij=−H+μI−1∇EE9
μ is the Levenberg–Marquardt parameter and I is the identity matrix.
This method, making a compromise between the direction of the gradient and Newton’s method, has the particularity of adapting to the shape of the error surface. Indeed, for low values of μ, the Levenberg–Marquardt method approaches Newton’s method, and for large values of μ, the algorithm is quite simply a function of the gradient, knowing that the parameter μ is automatically updated based on the convergence of each iteration.
Stabilization is possible thanks to a reiterative process, i.e. if an iteration diverges, it can be started again by increasing the parameter μ until a convergent iteration is obtained. However, the phenomenon of strong divergence when approaching the optimum, inherent in Newton’s method, is in no way suppressed here. At most, the divergence can be reduced.
Despite the interesting properties of this method, calculating the inverse of H+μI, makes its use tricky for heavy neural networks. As a result, like Newton’s method, it is advisable to automatically switch to the conjugate gradient method when this divergence phenomenon appears. Second-order methods greatly reduce the number of iterations, but increase the computation time.
3.3 Heuristic optimization methods
The advantage of heuristic optimization methods is the minimization of non-derivable cost functions, even for a large number of parameters (1<n<105).
Among the effective methods, we distinguish the optimization algorithm by Particle Swarms introduced by Kennedy and Eberhart and improved by Clerc is an optimization technique by agents which is essentially inspired by the behavior social in flocks of birds or schools of fish.
In addition, genetic algorithms, evolutionary algorithms, also constitute stochastic optimization techniques inspired by the theory of evolution according to Darwin, now widely used in numerical optimization, when the functions to be optimized are complex, irregular, poorly known or in question. Combinatorial optimization.
These heuristic methods of the methods presented previously (Levenberg–Marquardt, Newton, Conjugate Gradient, …) by three main aspects:
they do not require the gradient calculation,
they study a population as a whole while deterministic methods treat an individual who will evolve towards the optimum,
they involve random operations.
Experience has also shown that if the components as well as the evolution parameters are carefully tuned, it is possible to obtain extremely efficient and fast algorithms. However, this adjustment step can be very delicate and constitutes a drawback of the implementation of these methods.
4. Tuning neural network controller using classical approach
The architecture shown in Figure 1 assumes the role of two neural blocks. Indeed, the weights of the neural model are adjusted by the identification error ek, however the weights of the neural controller are trained by the tracking error eck.
The multi-layer perceptron is used in the neural model and in the neural controller. Each block consists of three layers. The sigmoid activation function s is used for all neurons.
Concerning the neural network model, the jth output layer of the hidden layer is described as follows
hj=∑i=1n1wjixij=1,2,…,n2E10
where n1 is the number of nodes of the input layer, wji is the hidden weight, xi is the input vector of the neural model, x=ukuk−1uk−2…T, uk is the control input to the system and n2 is the number of nodes of the hidden layer given in the expression (3).
The output of the neural network model is given by the following equation
yrk+1=λs∑j=1n2w1jshjE11
where w1j is the weight from the hidden layer to the output layer and λ is a scaling coefficient. The compact form of the output is given by the following equation
yrk+1=λsh1=λsw1TSWxE12
with
x=xiT,i=1,…,n1,
W=wji,i=1,…,n1,j=1,…,n2,
SWx=shjT,j=1,…,n2,
w1=w1jT,j=1,…,n2.
The incremental change of the hidden weights Δwij, i=1,…,n1 and j=1..n2, is
Δwji=−η∂E∂wji=−η∂E∂e∂e∂h1∂h1∂hj∂hj∂wjiE13
Δwji=ηλs′h1S′Wxw1jxTekE14
with η is the learning rate, 0≤η≤1, S′Wx=diags′hjT,j=1,…,n2, s′h1 is the derivative of sh1 defined as follows
s′h1=sh11−sh1E15
ek is the identification error which is given by
ek=yk−yrkE16
and the function cost which is given by the following equation
E=12∑k=1Nek2=12∑k=1Nyk−yrk2E17
where N is the number of observations.
The incremental change of the hidden weights Δwij is used in the following equation
wjik+1=wjik+ΔwjikE18
However, the output weights are updated by the following equation
w1jk+1=w1jk+Δw1jkE19
where Δw1j is
Δw1j=−η∂E∂w1j=−η∂E∂e∂e∂h1∂h1∂w1jE20
Δw1jk=ηλeks′h1SWxE21
Concerning the neural network controller, the jth output layer of the hidden layer is
hcj=∑i=1n3vjix1ij=1,…,n4E22
where n3 is the number of nodes of the input layer, vji is the hidden weight and x1i is the input vector of the neural network controller x1=rkrk−1rk−2…T, rk is the desired value.
The output of the neural network controller is given by the following equation
uk=λcs∑j=1n4v1jshcj=λcs∑j=1n4v1js∑i=1n3vjix1iE23
where n4 is the number of nodes of the hidden layer, λc is a scaling coefficient and v1j is the output weight.
The compact form of the output of the neural network controller is given by the following equation
uk=λcshc1=λcsv1TSVx1E24
with
x1=x1iT,i=1,…,n3,
V=vji,i=1,…,n3,j=1,…,n4,
SVx1=shjT,j=1,…,n4,
v1=v1jT,j=1,…,n4.
Concerning the hidden synaptic weights, they are updated by
or in Eq. (33), yk does not depend on h1, for this reason we use yrk instead of yk under the condition that the neural model is equal to the system behavior which gives
the obtained incremental change Δv1j is rewritten as
Δv1j=ηcλcecks′h1w1jS′Wxwjis′hc1SVx1E36
In this section, we used a fixed learning rate, ηk (respectively ηck), and a derivative of sigmoid function s′h1=sh11−sh1.
This approach has two drawbacks. First, to find a suitable fixed learning rate ηk (respectively ηck), several tests are called which decreases the on-line operation. Second, when we use this type of derivative of sigmoid function, a large amount of error should not be spread to the weights of the output layer and the learning speed becomes very slow. In order to increase the learning speed, some of the new proposed approaches are proposed in the next section.
5. Tuning neural network controller using particle swarm optimization
An alternative technique is proposed, in this section, to optimize the neural network controller by implementing Particle Swarm Optimization algorithm. This algorithm works like animal behavior on finding foods and avoiding danger, where they will coordinate with each other to find the best position to settle. Likewise, PSO is directed by the movement of the best individual from the population, known as the social compound, and their own experience, known as the cognitive compound. The algorithm moves the set of solutions to find the best solution among them.
5.1 Mathematical formulation
In this study, the Particle Swarm Optimization Feedforward Neural Network (PSO NN) is applied to a multi-layered perceptron where the position of each particle, in a swarm, represents the set of synaptic weights of the neural network for the current iteration. The dimensionality of each particle is the number of synaptic weights.
Let us consider a search space of dimension D. A particle i of the swarm is modeled by a position vector
xij=xi1xi2…xiDTE37
and a velocity vector denoted
vij=vi1vi2…viDTE38
There is no concept of backpropagation in PSO NN where the direct neural network produces the learning error, objective function of each particle, based on the set of synaptic weights and biases, the positions of the particles. Each particle moves in the weighting space trying to minimize the learning error and keeps in memory the best position through which it passed, denoted
Pbestij=pbesti1pbesti2…pbestiDTE39
whereas the best position reached by the swarm is denoted
Gbestij=gbesti1gbesti2…gbestiDTE40
Changing the position means updating the synaptic weights of the neural network controller to generate the proper control law by reducing tracking error.
In each iteration k, the particles update their position by calculating the new velocity and move to the new position. At the iteration k+1, the velocity vector is calculated as follows:
w being a variable parameter making it possible to control the changing of the particle at the next iteration,
wvij is a physical changing component,
c1r1pbestijk−xijk is a cognitive changing component,
c2r2gbestijk−xijk a social component of changing,
c1 and social c2 are respectively, two cognitive confidence coefficients and social which are present the degree of attraction towards the best position of a particle and that of these informants,
r1 and r2 are two random numbers drawn uniformly in the interval 01 represent the proper exploration of particles in the search space.
The smallest learning error of each particle Pbesti and the smallest learning error found in the whole learning process Gbesti are applied to produce a fit of the positions towards the best solution or the targeted tracking error.
The position, at the iteration k+1, of particle i is then defined as follows:
xijk+1=xijk+vijkE42
Once the change in positions has taken place, an update affects both Pbesti and Gbesti vectors. At the iteration k+1, these two vectors will be updated according to the following two formulations:
Pbestik+1=Pbestikiffxik≥fPbestikxikelseE43
and
Gbestik+1=ArgminiPbestik+1E44
The algorithm is executed as long as one of the three, or all at the same time, of the following convergence criteria is verified:
the maximum number of iterations defined has not been reached,
the variation in particle speed is close to zero,
the value of the objective is satisfactory, with respect to the following relation:
∣fgbestjkk−fgbestjkk−α∣≤ε,withα∈1NE45
The parameter ε represents a tolerance chosen, most often, of the order of 10−5 and N is a number of iterations chosen of the order of 10.
5.2 The proposed algorithm of particle swarm optimization
In this section, a summary of the proposed algorithm of the PSO neural network controller is presented.
Random initialization of the positions and velocity of the N particles in the swarm,
For k: 1..N Do,
Repeat,
For all particles i Do,
Calculation of the control law uik from the controller input vector xck,
Calculation of the outputs of the system yik+1,
Evaluation of the positions of particles in the research space,
If the current positions of particle i produce the best objective function in its history Then,
Pbesti←eci,
If the objective function of particle i is the best overall objective function Then,
Gbesti←eci,
End If,
End If,
End For,
Moving of particles according to Eqs. (41) and (42),
Evaluation of particle positions,
Update Pbesti and Gbesti according to Eqs. (43) and (44),
Until reaching the stop criterion,
End of PSO.
In this section, we have proposed the PSO optimization steps of an indirect neural network adaptive controller. The corresponding algorithm will be applied for discrete SISO nonlinear systems.
6. Results and discussion
In this section, a time-varying nonlinear discrete systems is used which is described by the input–output model in the following Equation [21].
where yk and uk are respectively the output and the input of the time-varying nonlinear system at instant k; a0k, a1k and a2k are given by
a0k=1a1k=1+0.2coska2k=1+0.2sinkE47
The trajectory of a1k and a2k are given in the following Figure 2.
Figure 2.
a1k and a2k trajectories.
Figure 3.
The NN control system output and the desired values.
In this section, in order to examine the effectiveness of the proposed algorithm of neural network controller and the PSO neural network controller different performance criteria are used. Indeed, the mean squared tracking error (MSEec) and the mean absolute tracking error (MAEec) are, respectively, given by respectively, given by
MSEec=1N∑k=1Nyk−rk2E48
and
MAEec=1N∑k=1Nyk−rkE49
where yk is the time-varying system output, rk is the desired value and the used number of observations N is 100.
In this simulation, the desired value, rk, is given in the following
rk=sin2πk/25;E50
6.1 Simulation system using classical NN controller
In this section, we examine the effectiveness of the used classical neural network controller in the adaptive indirect control system. Indeed, in offline phase, using a reduced number of observations M=3 to find, either, the parameter initialization of the neural network parameters (w1j, wji, v1j, vji).
In online phase, at instant k+1, we use the input vector of the neural network controller x1=xrkxrk−1xrk−2xrk−3xrk−4T. The results of simulation are given by Figures 3–5.
In this case, both neural network model and neural network controller consist of single input, 1 hidden layer with 8 nodes, and a single output node, identically. The used scaling coefficient is λ=λc=1 and ε1=ε2=10−2.
Using a multilayered perceptron architecture, three layers: one input layer, one hidden layer and one output layer. The result of simulation are given by the following figures.
6.2 Simulation system using PSO NN controller
The PSO parameters values are respectively the number of variables (m = 50), the population size (pop = 10), the maximum of inertia weight 0.9, the minimum of the inertia weight 0.4, the first acceleration factor (c1 = 2) and the second acceleration factor (c2 = 2).
Using a multilayered perceptron architecture, three layers: one input layer, one hidden layer and one output layer. The result of simulation are given by the following figures.
Figure 6 presents the control system output and the desired values. In this case, the neural network parameters of controller are optimized by PSO technique. A concordance between the desired values and the control system output is noticed, although the time-varying parameters.
Figure 4.
The control law.
However, Figures 7 and 8 present respectively the control law and the control error. These figures reveal that the PSO NN controller has smaller errors than the other controller.
Figure 5.
The control error.
Table 1 presents the influence of the PSO technique in the control error.
NN controller
PSO NN controller
η
variable
variable
MSEec
0.0349
3.7730e−04
maxec
0.3291
0.1372
minec
−0.4907
−9.9998e−04
MAEec
0.1305
0.0043
time (s)
323.829
100.926
Table 1.
The influence of the PSO technique in the control error.
From Table 1 we observe that, using the neural network controller, the PSO neural network controller has the smallest performance criteria in the control error eck. These results are shown in Figures 6–8.
Figure 6.
The PSO NN control system output and the desired values.
Figure 7.
The control law.
Figure 8.
The control error.
6.3 Effect of disturbances
An added noise vk is injected to the output of the time-varying nonlinear system in order to test the effectiveness of the proposed optimization technique of the neural network controller. To measure the correspondence between the system output and the desired value, a Signal Noise Ratio SNR is taken from the following equation:
SNR=∑k=0Nyk−y¯∑k=0Nvk−v¯E51
with vk is a noise of the measurement of symmetric terminal δ, vk∈−δδ, y¯ and v¯ are an output average value and a noise average value respectively. In this paper, the taken SNR is 5%.
Using the desired value rk, the sensitivity of the proposed neural network controller is examined in Table 2.
NN controller
NN PSO controller
ηc
variable
variable
MSEec
0.0351
3.7728e−04
MAEec
00.1247
0.0042
maxec
0.3123
0.1372
minec
0.5000
−9.9999e−04
time (s)
44.456972
337.728385
Table 2.
The influence of the PSO optimization in the control error.
From this table, we observe that, using the PSO as a method to optimize the parameters of neural network controller, we have got the smallest performance criteria in the control error.
According to the obtained simulation results, the lowest MSEec, MAEec and maxec are obtained using a combination between the neural network controller and the PSO technique, although the added disturbance in the system output and the time-varying parameters thanks to the PSO technique.
7. Conclusion
In this chapter, a comparative study between the neural network controller and neural network PSO controller is proposed and is applied with success in indirect adaptive control. For instance, the lowest MSEec, MAEec, minec and maxec are obtained and it is proved that the PSO method is the best. The effectiveness of the proposed algorithm is successfully applied to single-input single-output system, with and without disturbances, and it proved its robustness to reject disturbances and to accelerate the speed of the learning phase of the neural model and neural controller.
\n',keywords:"neural networks, particle swarm optimization, indirect control, nonlinear system",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/75577.pdf",chapterXML:"https://mts.intechopen.com/source/xml/75577.xml",downloadPdfUrl:"/chapter/pdf-download/75577",previewPdfUrl:"/chapter/pdf-preview/75577",totalDownloads:195,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:47,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"December 20th 2020",dateReviewed:"February 4th 2021",datePrePublished:null,datePublished:"July 14th 2021",dateFinished:"March 5th 2021",readingETA:"0",abstract:"This chapter proposes an optimization technique of Artificial Neural Network (ANN) controller, of single-input single-output time-varying discrete nonlinear system. A bio-inspired optimization technique, Particle Swarm Optimization (PSO), is proposed to be applied in ANN to avoid any possibilities from local extreme condition. Further, a PSO based neural network controller is also developed to be integrated with the designed system to control a nonlinear systems. The simulation results of an example of nonlinear system demonstrate the effectiveness of the proposed approach using Particle Swarm Optimization approach in terms of reduced oscillations compared to classical neural network optimization method. MATLAB was used as simulation tool.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/75577",risUrl:"/chapter/ris/75577",book:{id:"10390",slug:"deep-learning-applications"},signatures:"Sabrine Slama, Ayachi Errachdi and Mohamed Benrejeb",authors:[{id:"342622",title:"Associate Prof.",name:"Ayachi",middleName:null,surname:"Errachdi",fullName:"Ayachi Errachdi",slug:"ayachi-errachdi",email:"errachdi_ayachi@yahoo.fr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"344394",title:"Dr.",name:"Sabrine",middleName:null,surname:"Slama",fullName:"Sabrine Slama",slug:"sabrine-slama",email:"slema.sabrine@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Problem statement",level:"1"},{id:"sec_3",title:"3. Neural network optimization methods",level:"1"},{id:"sec_3_2",title:"3.1 Gradient back-propagation algorithm",level:"2"},{id:"sec_4_2",title:"3.2 Second order optimization method",level:"2"},{id:"sec_5_2",title:"3.3 Heuristic optimization methods",level:"2"},{id:"sec_7",title:"4. Tuning neural network controller using classical approach",level:"1"},{id:"sec_8",title:"5. Tuning neural network controller using particle swarm optimization",level:"1"},{id:"sec_8_2",title:"5.1 Mathematical formulation",level:"2"},{id:"sec_9_2",title:"5.2 The proposed algorithm of particle swarm optimization",level:"2"},{id:"sec_11",title:"6. Results and discussion",level:"1"},{id:"sec_11_2",title:"6.1 Simulation system using classical NN controller",level:"2"},{id:"sec_12_2",title:"6.2 Simulation system using PSO NN controller",level:"2"},{id:"sec_13_2",title:"6.3 Effect of disturbances",level:"2"},{id:"sec_15",title:"7. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Slama S., Errachdi A. and Benrejeb M., Adaptive PID controller based on neural networks for MIMO nonlinear systems, Journal of Theoretical and Applied Information Technology, 97, no. 2, pp. 361–371, 2019'},{id:"B2",body:'Errachdi A. and Benrejeb M., Performance comparison of neural network training approaches in indirect adaptive control, International Journal of Control, Automation and Systems, 16, no. 3, pp. 1448–1458, 2018'},{id:"B3",body:'Saurabh G., Karali P. and Surjya K.P., Particle swarm optimization of a neural network model in a machining process, Sadhana 39, Part 3, June 2014, pp. 533–548. Indian Academy of Sciences'},{id:"B4",body:'Zhou J., Duan Z., Li Y., Deng J. and Yu D., PSO-based neural network optimization and its utilization in a boring machine. J. 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Tunis El Manar University, National Engineering School of Tunis, Department of Electrical Engineering, Le Belvédère B.P. 37, Tunis, Tunisia
Tunis El Manar University, National Engineering School of Tunis, Department of Electrical Engineering, Le Belvédère B.P. 37, Tunis, Tunisia
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1. Introduction
The smart polymers hydrogels are the class of functional polymers, which finds extensive use [1, 2] in diverse areas like agricultural, medical, pharmaceutical, effluent treatment, textile, etc. They have physicochemically crosslinked three-dimensional network, which are derived from water-soluble acrylic monomers, crosslinkers and natural pre-polymers. These smart hydrogels are capable of imbibing and retaining water or aqueous fluids such as urine, blood, electrolyte solution, etc. to the extent of 200 g to 1–2 kg of fluids without dissolving [3, 4, 5]. This hydrophilic nature of hydrogel leads to managing drought conditions in arid and semi-arid regions as a matrix for the controlled release of water and fertilizers [5]. To serve this, polymers with different chemical architecture are essential for diverse soil characteristics [5].
Agrochemicals such as primary and secondary fertilizers are used to hike crop yield with substantial quality foodstuff [6]. However, the traditional method of growing foodstuffs using synthetic fertilizers will not ensure a high-quality environment [6]. Depending on the method of application and climatic conditions, about 90% of conventionally applied fertilizers never reach their objectives to realize the desirable biological response at the precise time and in the quantities required [6]. Such a mode of application provides a higher initial concentration than required for quick results. The conventional method of fertilizer amendment provides an initial concentration far above that required for immediate results to ensure the availability of sufficient nutrients. But such overdosing will result in waste of fertilizers [6] and produce undesirable side effects in the environment. Hence, there is a need for more controlled application of fertilizer, affording lower amounts of active ingredients without diminishing the efficacy. Controlled-release formulations were used to maintain an effective local concentration of active ingredients in the soil and to reduce runoff [6]. Besides, the application frequency required in the growing season could be minimized through controlled release technology. The controlled release was defined [6] as a technique or a method by which water or active chemicals were made available to a specified target at a definite rate and duration designed to accomplish an intended effect [7, 8, 9, 10, 11, 12, 13, 14, 15]. The method of choice to achieve controlled release in a particular application depends on the cost, release rate, potency and properties of the active compounds [14, 15, 16]. This chapter addresses the synthesis, characterization and controlled release applications of synthetic and natural polymer modified hydrogels in agriculture as matrices [16], different types of hydrogel used for controlled release, advantages, limitations and challenges.
2. Synthesis of hydrogels for controlled release
The smart hydrogels with controlled release characteristics have been prepared either from water-soluble acrylic monomers, crosslinkers and modified natural polymer by grafting.
2.1 From hydrophilic monomers
The hydrogels with good swelling ability are synthesized from water-soluble hydrophilic acrylic monomers such as acrylamide, acrylic acid, acrylates, itaconic acid, etc. using suitable initiators and crosslinkers through radical or photochemical polymerization methods [17]. This will be achieved either by solution or suspension or emulsion or bulk polymerization methods [17]. Free-radical polymerization mechanism is predominantly employed to synthesize hydrogel using olefinic monomers. The initiation of monomers is carried out by the initiators such as peroxides (benzoyl or t-butyl peroxides), azo-compounds (azobisisobutyronitrile) and persulphates. Peroxides and peroxy compounds can facilitate ambient temperature polymerization under the influence of tetramethylene diamine, sodium metabisulfite/ferrous salts, triethylamine, etc. [17, 18]. Benzyl alcohol, ethanol, water, and ethanol-water mixtures are commonly used solvents to achieve solution polymerization. The monomers (Table 1), cross-linkers (Table 2) and natural polymers (Table 3) that are used for hydrogel synthesis are given in the respective Tables.
Table 1.
Typical monomers used for hydrogel synthesis.
Table 2.
Typical crosslinkers used for hydrogel synthesis.
Table 3.
The representative natural pre polymers used for hydrogel synthesis.
2.2 Modification of natural pre-polymers
Water swellable hydrophilic hydrogel polymer can also be synthesized by performing appropriate chemical modification of natural polymers such as gelatin, starch, alginate, cellulose, chitosan, pectin, etc. via grafting using acrylic monomers. In-situ incorporation of micronutrient (boron) on acrylic acid grafted guar gum-based hydrogel [19], acrylic monomers grafted chitosan hydrogel [20], urea loaded cellulose [21], carboxymethylcellulose-hydroxyethylcellulose cross-linked with citric acid [22], etc. can also be used as matrices for the controlled release of fertilizers and water in agricultural field.
3. Characterization
3.1 Analytical methods
The potential applicability [23] of smart polymers are gauged based on their chemical structure, the extent of chemical and physical crosslinking, crosslink density, mechanical properties, degrees of swelling (hydrophilicity), release characteristics, hydrophobicity, surface morphology, biodegradability, biocompatibility, glass-transition temperature, thermal stability, photo-stability, bio-resorbability, interaction with biological fluids, environmental sensitivity, dielectric properties, toxicity, the toxicity of the degraded products, etc. For instance, the nature of functional groups, crystallization deformation of polymers, biodegradation, moisture uptake properties, nature of interactions between components are evaluated using Fourier Transform Infrared Analysis (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. The modification after polymerization such as chemical composition, grain size, the extent of crosslinking, pore size, pore volume are evaluated using Atomic Force Microscopy (AFM) or Scanning Electron Microscopy (SEM) and X-ray diffraction analysis. The oxidative thermal degradation, glass transition temperature, lifetime prediction, melting point, etc. are assessed through Thermal Analysis (TGA and DSC). The mechanical characteristics such as tensile strength and elastic moduli and strain are evaluated using a tensile-compressive tester.
3.2 Swelling measurements
The swelling ability of hydrogel is a significant characteristic for field application. The absorption capacity of the hydrogel can be evaluated [23] gravimetrically at successive time intervals using tea-bag, sieves, centrifugal, volumetric, microwave, gravimetric, NMR, DSC methods based on the required precision. The extent of swelling (DS) was measured using Eq. (1) by performing triplicate measurements.
DS=Wt−W0W0E1
The weight of dried (W0) and swollen polymers Wtat a particular time are measured gravimetrically.
3.3 Absorption under load (AUL)
The extent of water absorption under load is determined by performing AUL of hydrogel samples [24] using the Eq. (2). The AUL test will display the absorption capacity of smart polymer hydrogel under stressed conditions (load) and ionic strength.
AULg/g=W2−W1W1E2
W1 and W2 represents weight of dry and swollen hydrogel respectively.
3.4 Fertilizer uptake and release studies
The quantum of fertilizer absorption and release characteristics of smart hydrogels are measured based on Eq. (3). The percentage release of fertilizer from the loaded hydrogels are measured gravimetrically [12]. This procedure was followed for every two-day interval to ensure maximum fertilizer release. The percentage of urea/potash release was calculated [12] using Eq. (3).
Percentage of fertilizer released=∆Wn×100−n−1×2/2+∑i=1n−1∆WiWoE3
The amount of fertilizer released from the hydrogel in 2 and ith ml are represented by W0 and (ΔW)i respectively. The number of nutrient releases at different time intervals for the single experiment is denoted by the term “n”.
3.5 Transport kinetics
The rate of nutrient absorption by the plants depends on various parameters such as plant age, nature of fertilizers, and the concentration of fertilizers. However, the micronutrients are supplied as chelates or complexes (using synthetic complexing agents such as salicylic, lactic, formic, citric, succinic, propionic, ascorbic, tartaric and gluconic acids and their sodium, potassium and ammonium salts. Amino acids such as glutamine cysteine, glycine, and lignosulfonates can also be used as complexing agents [25]. The water, nutrients uptake and release behavior of hydrogels are regulated by their chemical constituents namely sulfonic acid, amide, hydroxyl, amine, carboxylic acid, carboxylate groups, etc.
The uptake and release mechanisms are clearly understood by analyzing the transport kinetics. The movement of solvent and solute either into or out of hydrogel is also regulated by the shrinking and swelling of hydrogels. The second-order kinetic model [Eq. (4)] was used to explain the swelling of hydrogel [23].
dMdt=ksM∞−M2E4
where, M: uptake at time t, M∞: uptake at equilibrium condition, and ks: kinetic rate constant.
The swelling rate (SR), and swellability (St) and(St+∆t) at time ‘t’ and ‘t+Δt’ respectively are measured using the Eq. (5).
SR=St+∆t−St∆tE5
3.6 Diffusion
A random molecular process causes the movements of solvent or solute molecules from one part to another part of hydrogels. Further, this movement is also influenced by temperature, pressure, solute size and viscosity. Generally, in hydrogel water molecules diffusion is connected to the extent of polymer-solvent interactions. Based on hydrogel relaxation rate, the diffusion is categorized as non-Fickian and Fickian [26], and the power-law Eq. (6) is used to evaluate the penetration characteristics of solvent into the hydrogel [26].
Mt=ktnE6
The value of diffusion exponent (n) is ranged from 0.5 to 1 and the parameter k represents the rate constant.
3.7 Fickian and non-Fickian
The diffusion mechanism [26] of solution in the hydrogel during network collapse or swelling was analyzed using Fick’s law. Fickian diffusion was noticed when the operating temperature of the system was greater than the glass transition temperature (Tg) of the hydrogel. Fickian type diffusion was also predicted if the solvent diffusion rate (Rdiff) was slower than hydrogel relaxation rate (Rrelax) i.e., (Rdiff <<Rrelax). Besides, the diffusion distance and the square root of time were found to have a direct relationship [Eq. (7)]
Mt=kt1/2E7
The value of ‘n’ provides the diffusion characteristics, for instance, if n = 0.5 in Eq. (6) Fickian diffusion is followed, and the ‘n’ values lie between 1 and 0.5 non-Fickian (anomalous) transport mechanism is followed. Further, non-Fickian model was noticed below glass transition of the hydrogel.
4. Application of hydrogel in agriculture field
The substantial foodstuff production requires an adequate amount of primary and secondary nutrients [6] along with water during cultivation. To achieve expected yield farmers used to feed an additional amount of fertilizers than the required quantity [6] during each amendment. However, 90% of the applied fertilizers are going as waste due to different climatic conditions and the application method [6]. An excess dose of fertilizers leads to economic losses, toxicity problems and effects on aquatic organisms [6] which cause uninvited effects such as water and soil pollution. Hence, there is a necessity to adopt the method, which facilitates the controlled release of fertilizers without affecting efficacy. An execution of controlled release using polymer based matrix is being used for a long time [6]. The loaded fertilizers have been released through chemical cleavage of the polymer-active agents or by depolymerization reaction (originated other factors) [6]. However, the implementation of a controlled release technique for the particular application depends on the factors namely release rate, cost, effectiveness and properties of synthetic fertilizers.
4.1 Advantages
In agricultural field, smart hydrogels have discharged numerous applications [27] and the notable merits are minimum use of fertilizers and water through controlled a release mechanism. The list of noteworthy advantages of hydrogel amendment in the soil is displayed in Figure 1. However, hydrogels used for the controlled release of fertilizers and water in the field must have
High water retaining ability with slow-release behavior
Excellent efficiency
Appreciable permeability and infiltration rate
Highly stable enough under various environmental conditions for the prolonged use
Reduced frequency of irrigation
Ability to undergo biodegradation without affecting soil fertility
Enhanced plant growth in arid and semiarid conditions
Figure 1.
Advantages of hydrogel in field.
The use of smart hydrogels in agricultural sector have attracted great attention as water management material in soil and matrices for the controlled release of primary and secondary fertilizers. The release rates of hydrogels [23, 27] are depends on the functional groups that are present in the polymer, functionality of crosslinker, pH, temperature, ionic strength of the medium, etc. Besides, the incorporation of natural pre-polymers in synthetic polymer hydrogel will bring down the operation cost, since they are readily available at a low cost and highly biodegradable. Nevertheless, natural polymer incorporation may induce a few limitations such as the lack of solubility of monomers in aqueous and non-aqueous solvents during hydrogel synthesis [16]. This characteristic behavior will result in excess utilization of pre-polymers to enhance agricultural yield.
The additional expected physicochemical and mechanical properties from the synthesized hydrogel for field applications are good stability during swelling (without dissolving), photostability, ability to uptake and hold maximum water with good swelling rate, particle size, maximum fertilizer uptake, porosity, odorless, neutral pH, colorless, low residual monomer content, non-toxicity, biodegradability without yielding toxic reside, and low cost [28, 29]. However, it should be remembered that the synthesis of hydrogel with all these features is difficult to achieve. However, some of its features namely porosity, stimuli responsiveness (pH and temperature), residual monomer content and swellability [30, 31, 32] are fine-tunable. The extent of hydrogel swellability, which are amended in the soil can be fine-tuned based on the requirement by making modification in the functional groups such as −NH2, −COOH, −OH, −CONH2, −CONH− and –SO3H. Besides, osmotic pressure, movable counter ions and capillary effect have also influenced swelling and release phenomena [33]. During swelling, the process of water uptake by the hydrogel will follow multiple steps that include hydration of polar hydrophilic and hydrophobic groups leading to the formation of primary and secondary bound water respectively. Meanwhile, infinite dilution of the hydrogel network will be resisted by the formation of either chemical or physical cross-links. Hence, the water molecules that are entering into the network during the initial and equilibrium stages are known as total bound and bulk water/free water respectively. During swelling these water molecules shall occupy the gaps available between chains and the midpoint of pores. The quantum of water uptake by the hydrogel networks is influenced by various parameters such as temperature, pH, nature of interactions, etc. that exist between networks and water molecules [33]. The list of representative hydrogels that are used as water-retaining agents and matrices for the controlled release of nitrate, potash, phosphate fertilizers are presented in Tables 4–7.
Representative hydrogels used for the controlled release of phosphate fertilizer.
4.2 Effects of hydrogel amendment
Smart hydrogel amendment in the soil during cultivation process will alter the hydraulic conductivity and pore size of soil to some extent due to water absorption [85, 86]. However, it will improve residual and saturated water content, which results in the reduction of subsequent water loss and infiltration due to percolation, this will facilitate aeration in soil due to expansion and contraction of hydrogel through absorption and evaporation [85]. The suitability of hydrogel for semi-arid and arid regions was due to the release of water and fertilizers with reference to environmental temperature, which results in increased survival [85] of plants. Besides, the hydrogel amendment has reduced the uptake of toxic metals and soil salinity by plants [87, 88].
4.3 Safety aspect and environmental concern
The practical applicability of hydrogel in field applications is dependent on safety, toxicity and eco-friendly degradability under soil conditions after its service and other environmental issues. Most of the hydrogels used in agricultural sector have stable service life (5–7 years), but their degradability is suspected. Hydrogels amended in the soil will experience stress from various factors such as microbes, light, pH, temperature, etc. The degradability of hydrogels depends on their structures and other environmental factors such as intensity of light, soil microbes, heat, pH, etc. The degradability of hydrogels could be attained by incorporating favorable functional groups such as ester, amide, urethane, anhydride, glycocidic (ether), urea, ortho-ester, carbonate, etc. in the backbone. The degradation sequence of polymers have predicted as anhydride > ester> orthoester> carbonate> urea>urethane> ether [89].
The monomers of hydrogels are known to be toxic and carcinogenic, but the polymer derived from the same monomers are proved to be non-toxic [18]. This characteristic behavior could be attributed to low boiling point and the low molecular weight of acrylic monomers and crosslinkers, which may effortlessly enter into the human body through skin absorption and inhalation [90, 91]. The studies have also recorded that these acrylic monomers imposed wide a range of health effects such as skin and eye irritation, allergic action, asthma, nerves problem, internal organ toxicity and impacts on fertility [90, 91]. The contentious exposures of acrylates will yield acrylic acid [90, 91] in the human body during metabolic activity. However, the crosslinked hydrogels will not cause any harmful effects on living organisms due to their insolubility and non-volatile nature [90, 91].
5. Conclusions
The chapter is focused on the development of smart hydrogels derived from synthetic monomers and natural pre-polymer for agricultural application as water retaining material and matrices for the controlled release of fertilizers. However, in the majority of the report, the mechanical properties of those hydrogels are not good enough for prolonged application in the field. Hence, this chapter addressed the route in which the mechanical properties of such hydrogel are fine-tuned. Besides, it focused on the typical hydrogels that are used for the controlled release of water, urea, potash and phosphate fertilizers, their advantages in the field, effects on the hydraulic conductivity of soil and their safety aspects.
Acknowledgments
The authors would like to thank Sri Ramakrishana Mission Vidyalaya College of Arts, and Science, Coimbatore and Bannari Amman Institute of Technology, Sathyamangalam, for encouraging this work.
Conflicts of interests
The authors declare that no conflicts of interests.
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Since the use of these hydrogels for controlled release application ensures the minimum utilization of water and plant nutrients in fields. Besides, this will bring down the overloading of fertilizer, soil contamination, and water pollution such as eutrophication, nitrate pollution, and micronutrient imbalance. This chapter is focused on the class of hydrogels that are used for the controlled release application in the agricultural and horticultural sectors as matrices, the possible methods of fine-tuning their structures for improving their fertilizer uptake and release behavior, safety aspects, and environmental issues.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81355",risUrl:"/chapter/ris/81355",signatures:"Dhanapal Venkatachalam and Subhapriya Pushparaju",book:{id:"11130",type:"book",title:"Hydrogels - From Tradition to Innovative Platforms With Multiple Applications",subtitle:null,fullTitle:"Hydrogels - From Tradition to Innovative Platforms With Multiple Applications",slug:null,publishedDate:null,bookSignature:"Prof. Lacramioara Popa, Dr. Mihaela Violeta Ghica and Prof. Cristina Dinu-Pirvu",coverURL:"https://cdn.intechopen.com/books/images_new/11130.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-583-6",printIsbn:"978-1-80355-582-9",pdfIsbn:"978-1-80355-584-3",isAvailableForWebshopOrdering:!0,editors:[{id:"228211",title:"Prof.",name:"Lacramioara",middleName:null,surname:"Popa",slug:"lacramioara-popa",fullName:"Lacramioara Popa"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Synthesis of hydrogels for controlled release",level:"1"},{id:"sec_2_2",title:"2.1 From hydrophilic monomers",level:"2"},{id:"sec_3_2",title:"2.2 Modification of natural pre-polymers",level:"2"},{id:"sec_5",title:"3. Characterization",level:"1"},{id:"sec_5_2",title:"3.1 Analytical methods",level:"2"},{id:"sec_6_2",title:"3.2 Swelling measurements",level:"2"},{id:"sec_7_2",title:"3.3 Absorption under load (AUL)",level:"2"},{id:"sec_8_2",title:"3.4 Fertilizer uptake and release studies",level:"2"},{id:"sec_9_2",title:"3.5 Transport kinetics",level:"2"},{id:"sec_10_2",title:"3.6 Diffusion",level:"2"},{id:"sec_11_2",title:"3.7 Fickian and non-Fickian",level:"2"},{id:"sec_13",title:"4. Application of hydrogel in agriculture field",level:"1"},{id:"sec_13_2",title:"4.1 Advantages",level:"2"},{id:"sec_14_2",title:"4.2 Effects of hydrogel amendment",level:"2"},{id:"sec_15_2",title:"4.3 Safety aspect and environmental concern",level:"2"},{id:"sec_17",title:"5. Conclusions",level:"1"},{id:"sec_18",title:"Acknowledgments",level:"1"},{id:"sec_21",title:"Conflicts of interests",level:"1"}],chapterReferences:[{id:"B1",body:'Ahmed EM. Hydrogel: preparation, characterization, and applications. Journal of Advanced Research. 2015;6:105-121. DOI: 10.1016/j.jare.2013.07.006'},{id:"B2",body:'Chen Y. Hydrogels Based on Natural Polymers. 1st ed. Amsterdam, Netherlands: Elsevier; 2019. pp. 1-533. DOI: 10.1016/C2018-0-00171-1'},{id:"B3",body:'Gul K, Gan RY, Sun CX, Jiao G, Wu DT, Li HB, et al. Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels. Critical Reviews in Food Science and Nutrition. 2021:1-6. 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DOI: 10.1002/agg2.20074'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Dhanapal Venkatachalam",address:"vdhanachemist@gmail.com",affiliation:'
Department of Chemistry, Sri Ramakrishana Mission Vidyalaya College of Arts and Science, India
Department of Chemistry, Bannari Amman Institute of Technology, India
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Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"27687",doi:"10.5772/29869",title:"Heavy Metals and Human Health",slug:"heavy-metals-and-human-health",totalDownloads:18954,totalCrossrefCites:83,totalDimensionsCites:191,abstract:null,book:{id:"1012",slug:"environmental-health-emerging-issues-and-practice",title:"Environmental Health",fullTitle:"Environmental Health - Emerging Issues and Practice"},signatures:"Simone Morais, Fernando Garcia e Costa and Maria de Lourdes Pereira",authors:[{id:"13875",title:"Prof.",name:"Simone",middleName:null,surname:"Morais",slug:"simone-morais",fullName:"Simone Morais"},{id:"79715",title:"Prof.",name:"Maria De Lourdes",middleName:null,surname:"Pereira",slug:"maria-de-lourdes-pereira",fullName:"Maria De Lourdes Pereira"},{id:"87294",title:"Prof.",name:"Fernando",middleName:null,surname:"Garcia E Costa",slug:"fernando-garcia-e-costa",fullName:"Fernando Garcia E Costa"}]}],mostDownloadedChaptersLast30Days:[{id:"64851",title:"Herbal Medicines in African Traditional Medicine",slug:"herbal-medicines-in-african-traditional-medicine",totalDownloads:14207,totalCrossrefCites:30,totalDimensionsCites:52,abstract:"African traditional medicine is a form of holistic health care system organized into three levels of specialty, namely divination, spiritualism, and herbalism. The traditional healer provides health care services based on culture, religious background, knowledge, attitudes, and beliefs that are prevalent in his community. Illness is regarded as having both natural and supernatural causes and thus must be treated by both physical and spiritual means, using divination, incantations, animal sacrifice, exorcism, and herbs. Herbal medicine is the cornerstone of traditional medicine but may include minerals and animal parts. The adjustment is ok, but may be replaced with –‘ Herbal medicine was once termed primitive by western medicine but through scientific investigations there is a better understanding of its therapeutic activities such that many pharmaceuticals have been modeled on phytochemicals derived from it. Major obstacles to the use of African medicinal plants are their poor quality control and safety. Traditional medical practices are still shrouded with much secrecy, with few reports or documentations of adverse reactions. However, the future of African traditional medicine is bright if viewed in the context of service provision, increase of health care coverage, economic potential, and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will hold much promise for the future.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Ezekwesili-Ofili Josephine Ozioma and Okaka Antoinette Nwamaka\nChinwe",authors:[{id:"191264",title:"Prof.",name:"Josephine",middleName:"Ozioma",surname:"Ezekwesili-Ofili",slug:"josephine-ezekwesili-ofili",fullName:"Josephine Ezekwesili-Ofili"},{id:"211585",title:"Prof.",name:"Antoinette",middleName:null,surname:"Okaka",slug:"antoinette-okaka",fullName:"Antoinette Okaka"}]},{id:"76640",title:"Control of Clinical Laboratory Errors by FMEA Model",slug:"control-of-clinical-laboratory-errors-by-fmea-model",totalDownloads:1131,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Patient safety is an aim for clinical applications and is a fundamental principle of healthcare and quality management. The main global health organizations have incorporated patient safety in their review of work practices. The data provided by the medical laboratories have a direct impact on patient safety and a fault in any of processes such as strategic, operational and support, could affect it. To provide appreciate and reliable data to the physicians, it is important to emphasize the need to design risk management plan in the laboratory. Failure Mode and Effect Analysis (FMEA) is an efficient technique for error detection and reduction. Technical Committee of the International Organization for Standardization (ISO) licensed a technical specification for medical laboratories suggesting FMEA as a method for prospective risk analysis of high-risk processes. FMEA model helps to identify quality failures, their effects and risks with their reduction/elimination, which depends on severity, probability and detection. Applying FMEA in clinical approaches can lead to a significant reduction of the risk priority number (RPN).",book:{id:"9808",slug:"contemporary-topics-in-patient-safety-volume-1",title:"Contemporary Topics in Patient Safety",fullTitle:"Contemporary Topics in Patient Safety - Volume 1"},signatures:"Hoda Sabati, Amin Mohsenzadeh and Nooshin Khelghati",authors:[{id:"340486",title:"M.Sc.",name:"Hoda",middleName:null,surname:"Sabati",slug:"hoda-sabati",fullName:"Hoda Sabati"},{id:"348872",title:"M.Sc.",name:"Amin",middleName:null,surname:"Mohsenzadeh",slug:"amin-mohsenzadeh",fullName:"Amin Mohsenzadeh"},{id:"348874",title:"MSc.",name:"Nooshin",middleName:null,surname:"Khelghati",slug:"nooshin-khelghati",fullName:"Nooshin Khelghati"}]},{id:"64762",title:"Mechanism and Health Effects of Heavy Metal Toxicity in Humans",slug:"mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans",totalDownloads:10236,totalCrossrefCites:100,totalDimensionsCites:229,abstract:"Several heavy metals are found naturally in the earth crust and are exploited for various industrial and economic purposes. Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"65467",title:"Anesthesia Management for Large-Volume Liposuction",slug:"anesthesia-management-for-large-volume-liposuction",totalDownloads:5965,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The apparent easiness with which liposuction is performed favors that patients, young surgeons, and anesthesiologists without experience in this field ignore the many events that occur during this procedure. Liposuction is a procedure to improve the body contour and not a surgery to reduce weight, although recently people who have failed in their plans to lose weight look at liposuction as a means to contour their body figure. Tumescent liposuction of large volumes requires a meticulous selection of each patient; their preoperative evaluation and perioperative management are essential to obtain the expected results. The various techniques of general anesthesia are the most recommended and should be monitored in the usual way, as well as monitoring the total doses of infiltrated local anesthetics to avoid systemic toxicity. The management of intravenous fluids is controversial, but the current trend is the restricted use of hydrosaline solutions. The most feared complications are deep vein thrombosis, pulmonary thromboembolism, fat embolism, lung edema, hypothermia, infections and even death. The adherence to the management guidelines and prophylaxis of venous thrombosis/thromboembolism is mandatory.",book:{id:"6221",slug:"anesthesia-topics-for-plastic-and-reconstructive-surgery",title:"Anesthesia Topics for Plastic and Reconstructive Surgery",fullTitle:"Anesthesia Topics for Plastic and Reconstructive Surgery"},signatures:"Sergio Granados-Tinajero, Carlos Buenrostro-Vásquez, Cecilia\nCárdenas-Maytorena and Marcela Contreras-López",authors:[{id:"273532",title:"Dr.",name:"Sergio Octavio",middleName:null,surname:"Granados Tinajero",slug:"sergio-octavio-granados-tinajero",fullName:"Sergio Octavio Granados Tinajero"}]},{id:"30178",title:"Chest Mobilization Techniques for Improving Ventilation and Gas Exchange in Chronic Lung Disease",slug:"chest-mobilization-techniques-for-improving-ventilation-and-gas-exchange-in-chronic-lung-disease",totalDownloads:31193,totalCrossrefCites:0,totalDimensionsCites:5,abstract:null,book:{id:"648",slug:"chronic-obstructive-pulmonary-disease-current-concepts-and-practice",title:"Chronic Obstructive Pulmonary Disease",fullTitle:"Chronic Obstructive Pulmonary Disease - Current Concepts and Practice"},signatures:"Donrawee Leelarungrayub",authors:[{id:"73709",title:"Associate Prof.",name:"Jirakrit",middleName:null,surname:"Leelarungrayub",slug:"jirakrit-leelarungrayub",fullName:"Jirakrit Leelarungrayub"}]}],onlineFirstChaptersFilter:{topicId:"3",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81607",title:"Does Physical Activity Mediate the Effect of Loneliness on Inflammatory and Metabolic Processes?",slug:"does-physical-activity-mediate-the-effect-of-loneliness-on-inflammatory-and-metabolic-processes",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.104915",abstract:"The study to be presented in the chapter explores one potential behavioral mechanism by which loneliness affects inflammatory and metabolic processes in old age. Specifically, it addresses whether physical activity mediates the loneliness—inflammatory/metabolic dysregulation association. Multivariate linear regressions were applied to data derived from the Health and Retirement Study (HRS). The findings revealed that loneliness was prospectively associated with elevated values of log C-reactive protein (log-CRP) and with amplified levels of Glycated hemoglobin (HbA1c), Cystatin C (CysC), and Body Mass Index (BMI), after controlling for socio-demographics. Second, physical activity mediated the association between loneliness with prospective values of log-CRP and also mediated associations between loneliness and prospective levels of metabolic biomarkers. These findings affirm the contribution (i.e., the mediation), of physical activity to the associations between loneliness and immune and metabolic processes and provide insights concerning the mechanism by which this social—biological connection operates.",book:{id:"11226",title:"Geriatric Medicine and Healthy Aging",coverURL:"https://cdn.intechopen.com/books/images_new/11226.jpg"},signatures:"Sharon Shiovitz-Ezra, Ohad Parag and Howard Litwin"},{id:"81961",title:"Antioxidants as an Adjuncts to Periodontal Therapy",slug:"antioxidants-as-an-adjuncts-to-periodontal-therapy",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105016",abstract:"It has been established that periodontal diseases are related with the hyperactivity of neutrophils. Reactive oxygen species are produced mainly by neutrophils. In order to maintain the balance with reactive oxygen species, the need for antioxidants is increasing. As for supplements to the conventional periodontal therapy, different antioxidants have been applied in an attempt to provide new possibilities in the periodontal treatment. This chapter focused on recent studies that used different antioxidants as adjuncts to conventional periodontal treatments.",book:{id:"11567",title:"Dental Trauma",coverURL:"https://cdn.intechopen.com/books/images_new/11567.jpg"},signatures:"Sura Dakhil Jassim and Ali Abbas Abdulkareem"},{id:"82462",title:"Quantitative Assessment Methods for the Severity of Drug Dependences and Corresponding Rehabilitation Programs",slug:"quantitative-assessment-methods-for-the-severity-of-drug-dependences-and-corresponding-rehabilitatio",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105582",abstract:"Drug use is a worldwide issue, and how to treat it is even a greater challenge. It is important for drug dependences to receive interventions and treatments in time. Before receiving treatments, an effective screening or diagnosis assessment is necessary, and patients should have an assessment to understand the severity of drug use–related disorders. For more than 40 years, the instruments to assess the severity of drug dependence have been developed well, and different quantitative methods can cover almost every field of the symptoms in different periods and stages of drug addiction. This chapter reviews more than 20 drug dependence screening and diagnosis assessments and different types of treatments. These quantitative assessments can provide drug dependences a comprehensive diagnosis of their drug use–related disorders. The treatments should be designed for different level of drug dependence.",book:{id:"11589",title:"Substance Use Disorder - New Research Perspectives in the Diagnosis, Treatment, and Prognosis",coverURL:"https://cdn.intechopen.com/books/images_new/11589.jpg"},signatures:"Zeng-Hui Ding, Yu-Xiang Qian, Cun-Feng Yuan, Xian-Jun Yang, Yu Liu, Yi-Ning Sun and Mu Wang"},{id:"82464",title:"Large Animal Models in Cardiovascular Research",slug:"large-animal-models-in-cardiovascular-research",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105754",abstract:"Studies of not only preclinical cardiovascular research but also those of life science, medical, and pharmacological fields commonly utilize small animal models. However, for the advancement of cardiovascular medicine, researches using large animal models are important step for preclinical validation of therapeutic efficacy and safety by virtue of having models with a body and heart size comparable with that of a human, providing clinically relevant experiments without the concern of over- or under-estimating therapeutic effects and risks. In particular, pigs are considered as a suitable animal model for research in cardiovascular medicine because of the similarities in physiology, metabolism, genomics, and proteomics to those in humans. Another advantage of pigs is the availability of various heart disease models such as myocardial infarction and genetically established cardiomyopathy. The present review updates the contributions of large animal model-based research to the development of cardiovascular medicine, especially focusing on the utility of pig models.",book:{id:"11711",title:"Animal Models and Experimental Research in Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11711.jpg"},signatures:"Hiroaki Osada, Kozue Murata and Hidetoshi Masumoto"},{id:"82345",title:"Cannabis Medicines: Guidance for the Selection, Purchase and Supply for Clinical Trials",slug:"cannabis-medicines-guidance-for-the-selection-purchase-and-supply-for-clinical-trials",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105682",abstract:"Cannabis medicines are in demand from the public for treating a range of diseases and symptoms; however, clinicians are reluctant to prescribe these products because of limited evidence and prescribing information. To generate this evidence, quality clinical trials of cannabis medicines must be undertaken, yet their design is a complex, often uncharted territory, and involves the cooperation and sharing of knowledge of multiple stakeholders. Before designing a clinical trial, researchers require a clear understanding of the potential therapeutic benefit cannabis medicines may have, the form and formulation of the product, and the dose to be investigated. Researchers must also be aware of the applicable pharmaceutical regulations in the country or jurisdiction where the research is to be undertaken, as well as manufacturing or licensing regulations that may be imposed at the source of the cannabis product. Importantly, collaborations with industry are a key to the successful outcome of cannabis medicines clinical trials. Without funding and sponsorship of clinical trials, the ability to generate quality data will be limited and the evidence for cannabis medicines to be registered as therapeutics lacking. Collaborations between researchers, industry, and regulators, working together in sharing knowledge, are therefore critical to generate high quality cannabis medicines research.",book:{id:"11714",title:"Cannabinoids - Recent Perspectives and Applications in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/11714.jpg"},signatures:"Peter Galettis, John Barlow, Jaroslav Boublik, Stefania Capra, Rachel Galettis, Myfanwy Graham, Courtney Hill, Paul Mavor, Jasminka Nikolajevic-Sarunac, Rosemary Richards, Janet Schloss, Melinda Thompson, Linda Truong, Berzenn Urbi, Katrina Weston-Green and Aaron K. Wong"},{id:"82463",title:"Side Effects of the COVID-19 Vaccines",slug:"side-effects-of-the-covid-19-vaccines",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105668",abstract:"Vaccination against COVID-19 was one of the most important discoveries in the fight against the pandemic and saved millions of lives. As with any vaccine, side effects have been reported, but the benefit of vaccination is much more important and should be considered. The most common side effects are mild to moderate, especially at the injection site, as well as self-limiting; non–life-threatening systemic reactions and severe reactions after vaccination are rare. In this chapter, the author will describe all types of side effects related to COVID-19 vaccines, information obtained from Web of Science, PubMed, Medline, Embase, Cochrane Library, Centre for Disease Control Prevention (CDC), cdc.gov database, and Vaccine Adverse Event Reporting System (VAERS).",book:{id:"11724",title:"COVID-19 Vaccines - Current State and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11724.jpg"},signatures:"Irina Magdalena Dumitru"}],onlineFirstChaptersTotal:793},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"June 20th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:13,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). 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She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"93",type:"subseries",title:"Inclusivity and Social Equity",keywords:"Social contract, SDG, Human rights, Inclusiveness, Equity, Democracy, Personal learning, Collaboration, Glocalization",scope:"
\r\n\tThis topic is dedicated to the efforts and promotion of UNESCO SDG4, the UNESCO initiative on the future of education, and the need for a new social contract for education. It aims to disseminate knowledge on policies, strategies, methods, and technologies that increase the resilience and sustainability of the development of the future of education and the new social contract for education. It will also consider the global challenges such as globalization, demographic change, digital transformation, climate change, environment and the social pillars of sustainable development.
\r\n
\r\n\tResponses to the pandemic and the widespread discontent that preceded it must be based on a new social contract and a New Global Deal for education that ensures equal opportunities for all and respects all people’s rights and freedoms (UNESCO; 2021). Such a new social contract, as proposed by UNESCO, must be based on the general principles underlying human rights - inclusion and equality, cooperation and solidarity, and collective responsibility and interconnectedness - and be guided by the following fundamental principle: Ensure that everyone has access to quality education throughout their lives.
\r\n
\r\n\tWe face the dual challenge of delivering on the unfulfilled promise of ensuring the right to quality education for every child, youth, and adult, as well as fully realizing the transformative potential of education as a pathway to a more sustainable collective future. To achieve this, we need a new social contract for education that eliminates inequities while transforming the future. This new social contract must be based on human rights and the principles of non-discrimination, social justice, respect for life, human dignity, and cultural diversity. It must include an ethic of care, reciprocity and solidarity. The new social contract builds on inclusiveness, equity, lifelong learning, SDG, collaboration and personal learning in a global context for democracy.
\r\n
\r\n\tAt an international level, the adoption of the Open Educational Resources recommendation and the Open Science recommendation represents an important step towards building more open and inclusive knowledge societies as well as the achievement of the UN 2030 Agenda. Indeed, implementing the recommendations will help to achieve at least five more Sustainable Development Goals (SDGs) that are intertwined with the topic of this book series, namely SDG 5 (Gender equality), SDG 9 (Industry, innovation and infrastructure), SDG 10 (Reduced inequalities within and across countries), SDG 16 (Peace, justice and strong institutions) and SDG 17 (Partnerships for the goals).
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11977,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null,series:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null},editorialBoard:[{id:"320585",title:"Ph.D.",name:"Deborah",middleName:null,surname:"Young",slug:"deborah-young",fullName:"Deborah Young",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002vZLcTQAW/Profile_Picture_2022-05-10T08:30:47.jpg",institutionString:"Empowering Communities Globally",institution:null},{id:"348038",title:"Associate Prof.",name:"Feyza",middleName:null,surname:"Bhatti",slug:"feyza-bhatti",fullName:"Feyza Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/348038/images/system/348038.jpg",institutionString:"Girne American University",institution:{name:"Girne American University",institutionURL:null,country:{name:"Cyprus"}}},{id:"302382",title:"Dr.",name:"Gina",middleName:null,surname:"Alvarado",slug:"gina-alvarado",fullName:"Gina Alvarado",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002mZoL9QAK/Profile_Picture_2022-05-26T08:14:10.jpg",institutionString:"Landesa, Seattle",institution:null},{id:"128665",title:"Prof.",name:"Man-Chung",middleName:null,surname:"Chiu",slug:"man-chung-chiu",fullName:"Man-Chung Chiu",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bR9OrQAK/Profile_Picture_2022-03-09T08:36:59.JPG",institutionString:null,institution:{name:"Beijing Normal University",institutionURL:null,country:{name:"China"}}}]},onlineFirstChapters:{paginationCount:7,paginationItems:[{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? 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