Teaching approach.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
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\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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Accepted submissions are of high scientific value based on previous research and include novel and innovative research. This book is a valuable resource for physical clinicians who have the opportunity to treat gout. The scientific content of this book will be beneficial to patients, students, researchers, educators, and healthcare providers who are interested in the recent progress in gout research and therapy, not only physical clinicians.",isbn:"978-1-78984-322-4",printIsbn:"978-1-78984-321-7",pdfIsbn:"978-1-83880-119-9",doi:"10.5772/intechopen.77945",price:100,priceEur:109,priceUsd:129,slug:"recent-advances-in-gout",numberOfPages:82,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"737c7c9f4b2c0fb7a9a6416dc39ab844",bookSignature:"Rie Kurose",publishedDate:"February 26th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8114.jpg",numberOfDownloads:4721,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:8,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 11th 2018",dateEndSecondStepPublish:"December 3rd 2018",dateEndThirdStepPublish:"February 1st 2019",dateEndFourthStepPublish:"April 22nd 2019",dateEndFifthStepPublish:"June 21st 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"176402",title:"Dr.",name:"Rie",middleName:null,surname:"Kurose",slug:"rie-kurose",fullName:"Rie Kurose",profilePictureURL:"https://mts.intechopen.com/storage/users/176402/images/9782_n.png",biography:null,institutionString:"Hirosaki Memorial Hospital",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Hirosaki University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"184",title:"Immunology, Allergology and Rheumatology",slug:"immunology-allergology-and-rheumatology"}],chapters:[{id:"67171",title:"Introductory Chapter: Gout",doi:"10.5772/intechopen.86253",slug:"introductory-chapter-gout",totalDownloads:693,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Rie Kurose",downloadPdfUrl:"/chapter/pdf-download/67171",previewPdfUrl:"/chapter/pdf-preview/67171",authors:[{id:"176402",title:"Dr.",name:"Rie",surname:"Kurose",slug:"rie-kurose",fullName:"Rie Kurose"}],corrections:null},{id:"70571",title:"The Gout",doi:"10.5772/intechopen.90540",slug:"the-gout",totalDownloads:677,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Gout is a form of arthritis in an individual accompanied with symptoms like severe pain, stiffness, and swelling of one or more joints. Factors that influence rates of gout are many like drinking alcohol, being overweight, drinking soda, becoming dehydrated, the weather, poorly fitting shoes, medical treatments, and many more. The root cause of this condition mainly we can say is the disorder of purine metabolism. There are diagnostic options like synovial fluid test, blood test for uric acid, and differential diagnosis. Preventive measures can include both lifestyle changes and medications. In a recent trend, many treatment options are available like the use of NSAIDs, colchicine, steroids, etc. Common drugs which are on use are probenecid, allopurinol, febuxostat, and pegloticase. Our medical fraternity and researchers are continuing to work on further development.",signatures:"Narottam Pal",downloadPdfUrl:"/chapter/pdf-download/70571",previewPdfUrl:"/chapter/pdf-preview/70571",authors:[{id:"282337",title:"Dr.",name:"Narottam",surname:"Pal",slug:"narottam-pal",fullName:"Narottam Pal"}],corrections:null},{id:"66515",title:"Pharmacology of the Therapeutic Approaches of Gout",doi:"10.5772/intechopen.85717",slug:"pharmacology-of-the-therapeutic-approaches-of-gout",totalDownloads:1393,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Gout is a metabolic disorder characterized by hyperuricemia. Asymptomatic hyperuricemia ought not to be treated until arthritis; renal calculi or tophi become evident. The cornerstone of therapy of acute attack is often nonsteroidal anti-inflammatory drugs (NSAIDs), barring specific situations wherein colchicine and corticosteroids do have a role. Usually NSAIDs with stronger anti-inflammatory action are used in high and quickly repeated doses and have a slower response response as compared to colchicine, they are better tolerated. Colchicine has a unique mechanism action. Intra-articular corticosteroids provide relief in acute attack and are given in patients having inability to tolerate NSAIDs and colchicine. Chronic gout requires treatments with drugs that either promote excretion (e.g., probenecid, lesinurad) or prevent its synthesis through inhibition of enzyme xanthine oxidase (allopurinol, febuxostat, etc.). Pegloticase and rasburicase, being a recombinant uricase enzyme, oxidize uric acid to highly soluble allantoin excreted in urine. In spite of these effective treatment modalities, question arises on their safety profile. Newer treatment options are being extensively studied especially interleukin-1 (IL-1) inhibitors but their approval is still pending. The quest for an optimally designed drug with desirable efficacy and acceptable safety profile is still on.",signatures:"Rajit Sahai, Pramod Kumar Sharma, Arup Misra and Siddhartha Dutta",downloadPdfUrl:"/chapter/pdf-download/66515",previewPdfUrl:"/chapter/pdf-preview/66515",authors:[{id:"262729",title:"Dr.",name:"Dr. Arup Kumar",surname:"Misra",slug:"dr.-arup-kumar-misra",fullName:"Dr. Arup Kumar Misra"},{id:"281062",title:"Associate Prof.",name:"Pramod Kumar",surname:"Sharma",slug:"pramod-kumar-sharma",fullName:"Pramod Kumar Sharma"},{id:"281486",title:"Dr.",name:"Siddhartha",surname:"Dutta",slug:"siddhartha-dutta",fullName:"Siddhartha Dutta"},{id:"281487",title:"Dr.",name:"Rajit",surname:"Sahai",slug:"rajit-sahai",fullName:"Rajit Sahai"}],corrections:null},{id:"66245",title:"Personalized Medicine of Urate-Lowering Therapy for Gout",doi:"10.5772/intechopen.85030",slug:"personalized-medicine-of-urate-lowering-therapy-for-gout",totalDownloads:864,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Gout is a common and complex form of arthritis that is characterized with hyperuricaemia. It is required urate-lowering therapy (ULT) for lifelong management. ULT includes decreasing uric acid product in serum, increasing renal urate excretion and promoting uric acid to allantoin for excretion. Whole genome association studies in gout identified more than 40 genetic loci that influenced the serum uric acid levels. Most associated genes were found to affect renal urate excretion. Pharmacogenetics and pharmacogenomics approaches on ULT had revealed several genes that underlined the effectiveness and the adverse events of medications for gout. Together with the researches on epigenetic factors such as DNA methylations, miRNAs; and the discovery of environmental factors such as microbiota and metabolites, the current progress provides the opportunities for personalized management of ULT for treating hyperuricaemia and gout.",signatures:"Dewen Yan and Youming Zhang",downloadPdfUrl:"/chapter/pdf-download/66245",previewPdfUrl:"/chapter/pdf-preview/66245",authors:[{id:"217452",title:"Dr.",name:"Youming",surname:"Zhang",slug:"youming-zhang",fullName:"Youming Zhang"},{id:"287948",title:"Prof.",name:"Dewen",surname:"Yan",slug:"dewen-yan",fullName:"Dewen Yan"}],corrections:null},{id:"65553",title:"Prophylaxis of Acute Arthritis at Initiation of Urate-Lowering Therapy in Gout Patients",doi:"10.5772/intechopen.84456",slug:"prophylaxis-of-acute-arthritis-at-initiation-of-urate-lowering-therapy-in-gout-patients",totalDownloads:1094,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"During the first months after the initiation of urate-lowering therapy in gout patients, the risk of exacerbation of arthritis considerably rises, which often results in discontinuation of the prescribed therapy by patients. The main way to avoid this risk is preventive prescription of colchicine, NSAIDs or glucocorticoids. Such prophylaxis of acute arthritis has been specified in a large number of the latest editions of various national and international guidelines; however, this tactics is rarely used in practice. 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The GERM gained momentum across the United States, United Kingdom, Australia and New Zealand [5, 6]. Seemingly, developing countries in the Pacific Islands were also influenced by the GERM influence [7, 8], and, Papua New Guinea (PNG) a Melanesian island country had no immunity to that influence [1, 9, 10].
Developments of Globalised Education Policies (GEP) such as the Universal Basic Education (UBE), Education For All (EFA), and Universal Primary Education (UPE) guided reforms for National Education Systems (NES) world over [1, 6]. Moreover, according to the literature, GEP placed emphasis on: Having a pre-determined education model/curricula to meet market oriented demands [4, 11, 12]. The GERM, arguably, was achieved world over when NES adopted a common education model (Outcomes-Based Education), and its subsequent Outcomes-Based Curricula (OBC) [1, 13, 14, 15]. The intentions were to improve educational performances and outcomes by using a universal framework advocating for quality education.
However, literature shows that reforming NES because of global policy mandates for implementation of a universal education model and curricula is not simple and straight forward [1, 11, 16]. Arguably, the process can be a highly complex one because of different factors and actors involved [2, 17]. Moreover, it is also stressed that trying to describe exactly where any reform agenda went according to global policy intentions could be problematic as, ‘No one shoe size fits all’ [3, 18]. Thus, there is an urgent need to document relationships of the GERM on local contexts, as Fullan [11] calls for more situated studies on global educational changes.
This Chapter hopes to answer the question:
This section discusses the theoretical lenses for understanding global education changes. Then it describes the climate driving global education reforms. Next it highlights processes of policy and implementation; and, last, gives descriptions of a scenario showing relationships between global agenda influencing local settings. The terms - ‘Innovation’, ‘change’ and ‘reform’, are used interchangeably here to refer to educational changes.
Rogers’ [19] diffusion of innovation theory offers three broad stages for making sense of how global education policy can influence local contexts. They are: Initiation, Implementation and Continuation.
The Initiation stage describes beginnings or diffusion of innovations/changes of something new like a reform agenda that will attempt to improve society. Changes may come from either external means (globally), or, internally from with systems or from both factors [5, 16]. If external donors drive reforms under development packages; timings and objectives could be constraints as projects have certain periods [14]. Thus, receivers of change need clarity from those initiating reforms from the onset; because, there could be sustainable issues, should subjective interpretations occur [20].
Decision makings here influence reform agendas [5]. Those dialogues can range from top-down, bottom-up, or from a combination of both approaches [21]; each has respective challenges and strengths. For example, in curricula reforms, priority considerations would need to go to: (a) Curriculum planning and policy statements, (b) Learning aims, and achievable strategies, (c) Project implementation (resources and staff development), and, (d) Classroom implementation (teaching and evaluation skills) [16, 22]. Seemingly, Initiation stages have numerous tasks, and, can be overwhelming when going into Implementation stages.
The Implementation stage happens after the initiation processes. Accordingly, implementation takes time to be embedded into systems [20, 23]. As approximations, the first three years of reforms are considered implementation periods [5, 16]. Interestingly, rejection or acceptance of reform agendas is possible in the implementation phase; both could affect reform continuation [20]. However, if the latter occurs, recipients of change may have adapted and modified practices. That illustrates surface adoptions of reforms; probably, without deep reflections of consequences [22]. Interestingly, records show political lobbying can be more influential, than rational thinking at this stage [5, 16]. Hence, the challenge of reform sustainability looms.
The Continuation phase captures sustainability of reform agendas. This stage provides spaces for research, monitoring, and evaluation [5, 16]. Two outcomes are possible here – taking ownership or retaining old ways. Outcomes may depend on the Initiation and Implementation stages which influence sustainability of reform agendas. For example, in curricula reform situations, if considerations were given to factors like teachers’ beliefs, attitudes, understandings or short trainings; then, the reform agenda could be sustained at school levels [2]. However, should resistance occur; then, literature suggests using Professional Development (PD) as intervention strategies to sustain curriculum implementation processes [23, 24]. The Continuation phase is equally challenging as; and interactive with the Initiation and Implementation stages of the diffusion of innovation theory.
In closing, the three lenses of the diffusion of innovation theory are used to examine relationships of global educational policies on a local context.
The UN developed numerous global policies for guiding operational matters worldwide. For instance, ‘Article 26’ of the Universal Declaration of Human Rights’, showed beginnings of global agenda driving national and local developments. Interestingly, the idea of UPE is entwined into - ‘Article 26′, and, thus; the notion of UBE was borne [25]. That hindsight was a global direction for countries to follow by providing quality basic education for children as obligations under the Convention on Children’s Rights [1, 15, 25].
Subsequently, the issue of UBE was given prominence on the world stage by international educational reformers in the mid-1990s (Delors [5, 26]). Apparently, EFA was the global agenda reiterating calls for countries to provide accessibility to education for all at basic levels so that retention rates could be decreased [17]. EFA was a treaty signed in 1990 in Jomtien, Thailand, and re-asserted in 2000 in Dakar, Senegal; EFA emphasised UBE; it is argued that UBE is a global indicator set by the UN to measure countries’ achievements of the Millennium Development Goals [1, 8, 13]. Educational changes that drive accessibility to learning opportunities refer to expanding education opportunities in countries [3, 17]. Seemingly, that was the common denominator of global education influence on local contexts which was also supported from the World Bank’s Reports [13, 17, 27]. In short, global education agenda guided UN member countries to align their national education frameworks within international requirements.
The literature reveals that different things on a global and local scale can also motivate educational reforms world over [5]. Some reasons include: Structural, organisational, systemic and pedagogical changes [3, 17]. For changes to take place; decision making processes are made either through top-down, bottom-up, or a combination of both [14]. Educational changes may be initiated from both outside influence as from a global perspective, or within local contexts [2, 15]. Interestingly, other reports on education reform do indicate that global education policies like the UBE and EFA had significant influence on education reforms in local contexts [3, 5, 17].
Mandated educational policies driving change are said to be top-down approaches. For instance, Education Ministries can instigate organisational changes and pass on decisions to stakeholders within their systems [3, 21]. This type of change is common in systems world over, like the Pacific Region with more centralised control from Education Ministries. Top down changes would require political will and the administrative processes within systems to drive change agendas. The discussions here show that policy of a common cause connects global and local contexts.
Policy and implementation as concepts connote relationships. Policy resonates with governance, and, is created to improve social systems [21]. Thus, official documents are deemed public policies because they are instruments guiding implementation of mandated agendas at different spheres of society. Implementation also captures meanings of Policy
Public policy evolves through three stages:
Governance - Refers to ‘authority’ [21]. This is the political decision making arena for policy development and application. This may eventuate through top-down, bottom-up, or a co-construction approach [14]. The top-down approach involves legislation from the hierarchy which is then passed down to subordinates via channels of communication within organisations. The bottom-up approach gets people working together to rectify issues. The co-construction approach refers to all stakeholders working together to develop solutions to social issues [23].
Policy - Is a legal document developed to improve social issues. Hence, mandating policy is intentional because objectives have to be achieved. Because many actors are involved in embracing policy, interpretations of it may vary and tensions may arise.
Implementation – Connotes an act of doing (implementing), which means that the activities have not yet been completed. Alternatively, it may refer to the state of having been done already (implemented) [21].
In summary, public policy has governance and implementation entwined in it and it can be clothed in different guises across different social contexts.
The GERM was pushed as policy mandates through the Outcomes-Based Education (OBE) model and it subsequent OBE curricular (OBC), [3]. A curriculum contains courses planned for studies in education systems [2]. However, that view, is narrow, as curriculum designs have inbuilt variables for understanding; before implementation can proceed. For instance: Curriculum aims, theoretical underpinnings of education model, teaching and learning theories, and developers’ intentions are few examples that illustrate a curriculum is not a single entity but contains processes that would need unpacking for clarity [2, 11]. As caution, subjective interpretations of policy curricula can happen during classroom implementation [1, 24]. Hence, that may impede continuation of reform processes.
According to literature, curriculum changes arise when there are perceived needs and, subsequently, curriculum reforms are undertaken with aims for improvement [11]. However, implementing a large scale curriculum change is not simple and straight-forward, but is a highly complex phenomenon [2]. For instance, Hall and Irving [23] noted in the New Zealand context that having a curriculum that is mandated to operate based on valid sound research could still have problems, if the policy makers, experts and practitioners are not working together to ensure that the curriculum (or curriculum innovation) not only “operates” but actually “works”; the distinction between “operating” and “working” draws attention to the need to ensure that the goals of the reform curriculum are achieved.
Furthermore, Markee [16] argues that implementing curriculum change is not just mandating policy for practices, but includes pedagogical changes to classroom practices, and; that possibly requires new teaching and testing approaches, involve new materials/resources, and possibly see alterations in teachers’ belief systems. Markee’s views show that curriculum change is complex and having one curriculum model (OBC) being championed globally can be problematic as the outcome can swing the other way as not expected. Furthermore, sometimes the intended meanings of curriculum developers may not be clearly understood by teachers who also have personalised teaching beliefs [5, 22] and this could impede practice, as Hall and Irving [23] observed in the New Zealand context. In closing, initiators of curriculum change would need to give close attention to teachers as they are vital for implementing in the classrooms any mandated reform agenda.
This section describes pre and post - independence educational issues in PNG to show relationships to global affiliations.
Educational issues in PNG have been prevalent since the 1970s. Documents from the 1974 ‘Eight Waigani Seminar’ held at the University of Papua New Guinea, showed national educators debating educational issues [2]. For instance, the type of education model adopted was considered foreign from colonial influence [28]. Assertions rose that indigenous students were alienated from village life after formal education [28, 29]. Consequently, the Matane Report (1986) was put together 11 years later to address the pre-colonial educational concerns (Ibid). The Matane Report, became the Ministerial Policy, and the
PNG’s reform from the onset was aligned with the 1990s global educational agenda, as a UN member [5, 14]. Thus, Australia through its developmental aid assisted PNG on adopting the OBE model for the national education system and embracing the OBC through a ‘Curriculum Reform Implementation Project’ (CRIP) [31, 32]. There are different interpretations of the OBE. Its champion, asserts that OBE has three main premises. It is an: 1) Education theory, 2) Instructional strategy, and, a, 3) Systems theory. Thus, having understandings of those three are crucial, as each; can influence the introduction and implementation processes of the OBC.
Seemingly, as an education theory, and, instructional strategy, OBE would resonate with student centred theories of teaching and learning. OBE discourages traditional direct instructions in classroom learning. Moreover, it asserts links with performance-based education, or an SCA way of teaching [33]. Arguably, OBE relates with principles of constructivism theory that believes students need to be proactive learners. That is, experiences and ideas from social environments are used to create new knowledge and meanings within classroom interactions. Mildly speaking, attests that schools determine successful learning outcomes. However, that comment applies to constructivism and behaviourism theories as well; so, is not only unique to OBE. Discussions here show that having both theoretical and content knowledge of curriculum model and pedagogy in subject specifications are requirements for implementing any reform curricula.
Arguably, as a systems theory, OBE rode on the mantra of global developmental frameworks, like the Paris Declaration on effective aid delivery into PNG [2, 10]. Subsequently, OBE was seen as a ‘
In summary, there is a relationship between global and reform in a local context. As seen here, both external and internal factors drove educational reform into the PNG national education system.
Since, the paper’s aim is to understand relationship of global educational policy on a local context (PNG), the constructivism theoretical lenses was used to interpret findings from data. It is said that knowledge is socially constructed, but subjective as in relationships, and embedded in people; so that premises underpinned the chosen framework for this paper.
This paper was derived from my PhD thesis grounded in a qualitative case study [2]. Two urban secondary schools; termed School 1 (S1) and School 2 (S2) in Port Moresby, PNG were the research sites. The former is in the north-east of the city, whilst the latter, north-west. Both schools were level nine schools with accessibility to policy information about the education reform [33]. One ‘W’ research question was asked to elicit detailed responses about the relationship of global education policy on the chosen local context. The question raised was:
There were two parts to data collection: the first part consisted of reviewing literature both online and offline around global educational changes, the Outcomes-Based Education Model, and curriculum reform policies. The key words scanned were global education reform policies and literature reviewed included:
Phases two consisted of data drawn from my PhD thesis which consisted of multiple data collection methods. Primary data consisted of: One to one 15 minutes semi-structured interviews (Two) with the principals, two one hour focus group discussions, eight lesson observations (40 minutes per lesson - total 320 minutes), observation field notes, and two 10 minutes post-observation interviews. The secondary data included: Document analysis of the PNG National Department of Education (NDoE) policies, teachers’ prepared worksheets, and literature reviews.
The data analyses in phase two involved transcribing all audio recorded interviews; focus group discussions, classroom observations, document reviews, and field notes. Content, discourse, thematic analyses were used to interpret data. Meanings were guided by the research question following a deductive approach, as well as, letting concepts rise from data using a grounded theory approach. Results from the two research sites were compared against policy intentions and described separately. Lastly, a cross-case analysis was done through triangulation to give validity and reliability to the findings.
There were 10 direct participants (teachers), and 90 indirect participants (students) who had taken part in the study; all were given code names. Participants were two school principals (P1-S1 and P2-S2), six focus group English teachers (FGT1-S1, FGT2-S1, FGT3-S1, FGT1-S2, FGT2-S2, and FGT3-S2), two grade nine English class teachers (ET1-S1 and ET2-S2), and about 90 students from the two observed grade nine classes (C1 and C2). Ethical clearance was sought both from the Ethics Committee of the Education Faculty at Victoria University Wellington (March 2009), and the NDoE in PNG (July 2009). Staff participants signed consent letters to be in the research, while, parents of the observed grade nine classes signed consent letters for the student participants as they were between 15 and 16 years of age.
Three concepts are discussed showing how global education policies influenced a local context (PNG). Those are: Factors facilitating change, little alignment, and, suggestions for improving curriculum reform.
Findings from both phases of data collection revealed that both global and national factors drove the PNG education reform. Seemingly, global development discussions of the 1990s influenced worldwide educational reform, and so PNG was no exception to that. For instance, the Paris Declaration Framework for effective aid delivery to third world nations influenced reforms through the UBE and EFA agendas. Consequently, OBE as a favoured educational model was championed globally, as it was considered economically viable to be used [8, 14, 35]. External partners supported educational aid to developing countries, and PNG was no exception [1, 13, 16]. In corroborating with that argument, participants from phase two data collections also spoke on that:
Furthermore, findings also showed that nationally, PNG had issues recommending educational reforms from the pre-independence era [36]. However, due to financial constraints, reforms were stalled till external influence in the forms of bi-lateral relationships helped [1, 9, 10]. Internally, PNG used systemic practices to drive her education reform. Deeply embedded practices like - Top-down decision making processes (of the NDoE dating back to its 1970 inception); hastened reform activities [2]. That corroborated what other PNG scholars described about ‘how’ change began [9, 10]. Seemingly, in top-down decision making, schools would have little say; being on edges of decision making formalities. That meaning is seen here:
In summary, global policy guided the PNG education reform. Interestingly, PNG went through hassles of initiating and implementing the OBE curriculum reform in the early 2000s, but had it shelved in 2013, because of political decisions. That political action also raises questions about PNG’s decision making processes, and, systemic abilities for sustaining large scale curriculum reforms driven by global agenda.
Whilst, the reformed curriculum looked encouraging for PNG as she would be seen to be meeting global and national requirements [2, 13]; actual classroom practices revealed otherwise [2]. This revelation is important for others to consider when global and national policies instigate educational changes for lower levels in social systems.
First, findings showed mismatches between policy intentions and observed practices in two areas - teaching theory, and, classroom practices (Table 1).
Policy Intention | Observation finding |
---|---|
A student-centred approach allows teachers to be more flexible in determining the most effective ways to help all students … ([33], p, 20). | All four observed lessons from C2 and two from C1 were all teacher-centred, grammar lessons taught in isolation (Field notes). |
Evidence from eight random lesson observations indicated features of Teacher-Centred Lessons (TCLs). This was despite policy intentions wanting changes to teaching practices. TCLs describe traditional approaches of teacher ‘talk and chalk’ teachings. Observations noted direct transmission teaching; this implicates teachers’ world views as being sources of knowledge, while, students were passive participants in their learning. That finding contradicted global policy intentions for a SCA for classroom implementation at a local level [2].
Second, the TCLs ideas were also found in the triangulation process (field notes, speech patterns, interviews, post observation interviews and focus group discussions). Evidence indicated that teachers’ theoretical preferences and worldviews were still entrenched in TCLs acquired presumably from teacher training [2, 10]. Furthermore, this finding supports literature’s contention that processes of implementing curriculum change is complicated, and, takes time to become systemic practices [5, 20, 23]. Moreover, it could also show that if deeply entrenched practices were deemed not compatible with reform agenda; then classroom implementation was challenging [22].
Third, a mismatch of policy intentions to practice was also noted in teachers’ behaviour. Policy required an SCA, but, teachers’ preferences were the TCLs. The gist is captured here:
Interestingly, the discussions here imply that the Initiating and Implementing phases of global education agenda [5] was not systematically and effectively managed at the local level in PNG [2, 37]. Thus, the findings contradicted the OBE champion, who says that governments need to resource systems, and train practitioners appropriately, before accepting the OBE. Arguably, teachers’ claimed the reform curriculum was insufficient as seen here: “
Because discussions here showed ‘little alignment’ between global policy intentions and local practice in the first three years of aligning national education with a global educational agenda [2] – Intervention strategies are proposed to help with knowledge gaps.
Discussions here revealed that knowledge gaps existed in relationships concerning alignment of national education reform principles with intended global requirements. Therefore, evidence here suggests using PD as an intervention strategy to purposefully embed and sustain large scale curriculum changes; irrespective of curricula model [2, 5, 11, 24]. Moreover, it is also recommended that regular PD trainings are done to help foster professional learning cultures into systemic practices [1, 23]. Evidence showed that practitioners were committed to national directives underpinned by global agenda. For instance:
The
The KF also resonates with western literature discussions on using PD to embed global education policies. In support, Fullan [11] and Hall & Irving [23], also argue that, for any educational change to survive in institutions, continuous PD practices need to be inbuilt into school environments to foster a culture of professional learning for practitioners who are the most important agents of any mandated reforms. Interestingly, using the Kibung Framework to run PD sessions link well with Rogers [19] Continuation phase of the diffusion theory to assist curriculum changes.
For instance, participants in Joskin’s [2] study understood that the OBE as a policy curriculum was an instrument of governance: “It is a policy that is going to be here, so whether we like it or not, we need to implement it” (P1-S1). This citation shows subordinates conforming to a central administration, who despite various personal reactions would ultimately implement the OBE Curriculum. Thus, the Kibung Framework borrows from Hall and Irving’s [23] PD suggestions as originally taken from eight identified factors for successful PD to embed global agenda locally.
Figure 1 below illustrates the seven attributes of the KF that would need to be taken into consideration when a local context like PNG tries to align curriculum reform with global agenda.
Kibung professional development framework.
Incorporates participants’ own aspirations, skills, knowledge and understanding into the learning context.
Engages participants in analysing data from their own settings. Identification of discrepant data is a mechanism to invoke revised understanding.
Involves critical reflection enabling participants to investigate and challenge assumptions and extend their thinking.
Helps participants change educational practice, beliefs, understandings and/or attitudes.
Helps participants gain awareness of their thinking, actions, and influence on others.
Focuses on the need for inclusiveness.
Involves engagement with pedagogy, and
Involves engagement with theoretical knowledge and alternate practices.
In closing, teachers would need to view PD as something that will not only change their educational practices, but would give them insights into being reflective learners, and help contribute to sustainable education.
In conclusion, the discussions in this Chapter have revealed that global educational policies do have impacts on relationships with education reforms in local contexts.
The functional responsibility of the immune system (humoral and cell-mediated alike) is to protect against infection by destroying various infectious agents when such agents attack the body or are introduced through vaccination [1]. The functioning of the immune system is coordinated and maintained by a sequence of highly regulated and physiological mechanisms which aids the identification and recognition of both body cells and foreign cells [2].
The body’s immune units usually coexist with other cells of the body that carries a self-marker molecule. Immune reactions are only triggered when an antigen which could be a microbe, part of a microbe or a molecule is presented to the surface of the cell and perceived by the body defenses [3].
The immune system of humans is made up of two divisions which are innate and acquired immunity. The innate immunity forms the first line of defense immediately after infectious agents are recognized by the body while acquired immunity functions in the removal of pathogens at the later phase of infection [3].
When the immune system is stimulated, it targets and destroys foreign units. Still, in some abnormal situation, the immune system might be insensitive to antigens, hypersensitive to antigens or recognize the cells with self-marker as foreign cells [2].
There are disease conditions that affect the immune system, which leads to different degree and types of conditions known as the Immune diseases. Diseases of the immune system include inherited and acquired immunodeficiency and immune-proliferative disorders which includes malignancies of the immune system (multiple myeloma, lymphoma, and leukemia), autoimmune diseases (rheumatoid arthritis), and immune hypersensitivities (allergies) [4]. Inherited immunodeficiency, also is known as primary immunodeficiency, refers to a large number of immune disorders which alters either or both development and function of the immune system. Primary immunodeficiency implies conditions resulting from loss of function, a gain of function or loss of expression due to monogenic germline mutations [5]. External and environmental factors can induce an adverse effect on the immune system, and this is regarded as secondary or acquired immunodeficiency, which is encountered commonly in clinical practice and could arise from quite a number of conditions [6].
The evolvement of medical practices especially diagnosis and treatment from the usual “one size fits all” approach to a more genetic and detailed patient stratification in a bit to acquire more information about the disease condition and the patient is known as personalized medicine [7].
The complexity of the body defense system and the ability of the cells associated with it to shift between different activation states under physiological and pathological conditions are some of the reasons for diversity in the treatment approach. The immune diseases at times are diverse, and this result in variations in response to therapy. The difference in the disease course also create reasons why there should be the identification of personalized marker for diagnosis of immune disease. Therefore, the use of genetic assessment to determine the best possible therapeutic approach from the numerous available options with different mechanisms, risks, and efficacy are essential [7, 8].
The Precision medicine data types, genomic data in precision medicine, genomic and personalized medicine databases, data sharing, access and use are discussed in this chapter. Also, the use of genomic methods and data in the understanding, diagnosis of diseases using specific biomarkers, monitoring of prognosis using prognosis biomarkers, personalized treatment of immune disorders, monitoring of response to treatment using response biomarkers are also described in this chapter.
Immunity is the ability of the body to prevent infection by resisting the invasion of such a body by harmful microorganism knows as infectious agents. Immunity can be categorized broadly into two types which are:
Innate or Natural Immunity and
Acquired Immunity
The initial host protection against diseases- causing agents is the innate immunity which is mediated by phagocytes. Through germline-encoded pattern-recognition receptors (PRRs), the innate immunity of the human body recognizes microorganisms invading its body. For the immune cells to be activated, different classes of the PRRs, which include Toll-like receptors and cytoplasm receptors recognize distinct and important microbial component of invading microorganisms thereby activating immune cells [3, 9].
Immediately after the detection of non-self-agents by PRRs which could be exhibited on the outer membrane of the cell, in intracellular parts, or released in the bloodstream and fluids of the body tissues, the PRRs then perform the function of opsonization, stimulation of complement and coagulation outflow, phagocytosis, initiation of pro-inflammatory signaling pathways, and inception of apoptosis. These cascades of intracellular signaling induce the expression of overlapping and unique genes which are involved in the inflammatory immune responses and essential in precision medicine. The reaction by the innate immune system is carried out by phagocytes (neutrophils, monocytes, and macrophages), inflammatory mediators releasing cells (basophils, mast cells, and eosinophils), and natural killer (NK) cells [3, 10].
Acquired immunity is the immunity that is developed against an infectious agent by the body after the previous encounter with a pathogen or a type of immunity developed by a child by the exchange of protective materials from mother to child before and after birth or by the injection of such substances. The mediation of adaptive immunity is the function of clonally distributed T and B Lymphocytes whose characteristics are the possession of specificity and memory. Many at times, activation of the innate immune response can trigger acquired immunity. The generation of Helper T cells subsets and the production of cytokines influence adaptive immunity [11, 12].
When naïve T-helpers cells are stimulated by Antigen-presenting Cells otherwise known as APCs, they differentiate into two subsets of T helper (TH) cells such as TH1 and TH2. Interferon-γ (IFN-γ) is produced by TH1 cells that solely promote cellular immunity. TH2 cells, on the other hand, produce interleukin 4, 5, 10 and 13 (IL-4, IL-5, IL-10, and IL-13). Whereas, IL-12 is the propelling source of TH1 separation while IL-4 stimulates TH2 distinction. TH2 is majorly involved in the promotion of humoral immunity [12].
The occurrence of the immunological disease is consequent to the dysregulation of numerous and different part of the human immune system. Fundamentally, the response of the immune system recognizes and eliminates antigens but tolerates its tissues. However, predominant immunopathology lesion is the basis on which the characterization of immune-mediated diseases is based. Immune-mediated disorders can be grouped into immediate hypersensitivity, autoimmunity, immune-complex disease, and delayed-type hypersensitivity. Autoimmunity can be further classified into those mediated by adaptive immunity and those mediated by innate immunity. Most of the disorders lie between the two, which will be best described as positive pathological feedback between innate and adaptive immune mechanisms [13]. Figure 1 below represents the pathogenesis of immune diseases.
Schematic representation of the pathogenesis of immune diseases.
Personalized medicine is the process of tailoring the diagnostic procedures, treatment, and preventive measures towards the characteristics of individual patients to get an optimal outcome for each patient while emphasizing easy accessibility and cost-effectiveness [14]. In the practice of personalized medicine, the characteristics of an individual, including the uniqueness of its genetic profile guide the clinical decision in the treatment. Prognostic, diagnostic and predictive biomarkers are always being searched to guide these clinical decisions, at the same time, ensure that the best treatment is offered to the right patient at the best time [15]. The division of personalized medicine is illustrated in Figure 2.
Diagram showing the different division of precision medicine.
While the method of application of precision medicine is given in Figure 3.
A flow chart representing application method of precision medicine.
Generally, personalized medicine compose of a vast collection of genetic data. The development of power systems has helped to increase the effective use of big data in personalized or precisions medicine over time. Also, the evolution of genomics data offers limitless possibilities in the design of clinical procedures, diagnostic, prevention, addressing and prediction of most favorable therapeutics for many diseases that are related to different regions and lineage [16].
The systematic collection of patient information is now accumulating and gaining complexity, as seen in the case of neuroimaging, which is currently producing above ten petabytes of data every year [17]. Studies in the field of precision medicine research make use of relevant data types such as Imaging data (CT, PET, UltraSound and MRI), bio-sample data (serum, plasma and urine value), molecular data, genomics data (nucleotide sequences), proteomic profiling data (mass spectrometry), digital pathology data, biomedical instrument data (blood pressure, heart rate and insulin level) and clinical data (death/survival data, demographics and medical-based questionnaire) and others [18].
Some of the achievement in Precision medicine has led to solutions, such as the birth of personalized brain models for a patient with intractable epilepsy [19] and the success in epigenetics mechanism of hematopoiesis [20]. The combination and integration of these data types require a sound understanding of the different fields of informatics (data science, data management and data curation) and bioinformatics [18].
A database is an ordered set of structured information or data usually controlled by the database management system (DBMS) in an electronic computer. The data, DBMS and the applications associated with them are called database system or database in short. Each database contains certain types of data; here, we will be introducing some of the database associated with personalized or precision medicine.
The IEDB is a free to use database that is very useful in vaccine and drug development, this database catalogs data such as experimental data on antibodies, Major histocompatibility complex (MHC) binding data from different antigenic sources, Helper T lymphocyte (HTL) and Cytotoxic T Lymphocytes (CTL) epitopes for human and other animal species. This database also aids in prediction and analysis of varieties of epitopes [21]. This database can be accessed through https://www.iedb.org/.
Lifestyle medicine is the study of association between lifestyle, chronic and immune diseases. PCaLiStDB is a lifestyle database that is channeled towards precision in the prevention of prostate cancer and other diseases associated with lifestyle. The data found in this database are lifestyle associated genes, lifestyle type biomarkers and personalized lifestyle-disease associated predictors [22]. The database link is http://www.sysbio.org.cn/pcalistdb/.
ClinGen database provides data that are of clinical importance, this database is funded by the National Institute of Health (NIH), and it is aimed at collecting necessary data for use in precision medicine and research. Data such as clinically relevant gene and variants are retrieved from this database in making precise diagnosis and treatment [23]. This database is accessed via https://clinicalgenome.org/.
One of the breakthroughs of medical informatics is the personal genome project database. This is an open-access database that is channeled towards the development of a tool for personalized medicine and advancing research. The database provides a wide range of data for different regions (PGP-UK, PGP-AUSTRIA, PGP-CHINA, PGP-CANADA and PGP-UNITED STATE, etc.). Data such as Genome, Methylome, transcriptome and phenotype data are retrieved from this database for use in the procedure of precise medicine [24]. The database can be linked through https://www.personalgenomes.org/.
This database was initiated in the early 1960s, and the online version was created in 1985. OMIM is an open-access database that is mainly built for professionals concerned with genetic disorders, a genetics researcher and advance students in medicine. Data such as human gene, genetic disorders, clinical features, phenotype and genes are available [25, 26]. This database address is https://www.omim.org/.
This is a variant-related database that collates already known gene lesion that is responsible for human inherited diseases. The database includes precision medicine data such as gene symbol, genomics coordinates, splicing, different disease, phenotype and mutations in the human genome [27, 28]. This database is accessible via http://www.hgmd.cf.ac.uk/ac/index.php.
Clinical Genomic Database fills the critical niche in the field of clinical and genomic medicine; it also encompasses medically significant genetic data with available interventions. For each entry in the database, the CGD gives out data such as allelic conditions, gene symbol, clinical categorization (both manifestation and interventions), affected age groups mode of inheritance and pathogenic mutation for all diseases so far captured [27]. This database can be accessed via https://research.nhgri.nih.gov/CGD/.
There are other ongoing database projects to improve the existing ones, an example of this is The Human Variome Project [29]. Also, there are many websites and databases linked to precision medicine that this chapter cannot introduce all. Table 1 below provides more of the database related to precision medicine in general and their links [30].
Database linked to precision medicine in general and their links [30].
Data sharing is the potential inherent in the exchange of the same data resource with many applications or users; it encompasses the transferring of copies, accessing and enabling the reuse of data. Data can be open access (publicly available) or controlled (restricted), also, sharing data encompasses both sharing of primary (in case of nucleotide sequences) and secondary data (already used or analyzed data) [31].
Figure 4 above illustrates that precision medicine data encompasses both hospital data (information), GIS and PGHD. Sharing of the Precision medicine information (clinical data) can be accessed openly or otherwise restricted, whereby authorization will be needed by an authorized person to access and use the specified data for therapeutic, diagnostic and research purpose.
Semantic diagram of genomic and personalized medicine data sharing
Autoimmune diseases are disease conditions where the immune system respond to self-antigens as a result of damage or dysfunction or disorder in the tissues. It is controlled by a whole lot of factors of which host gene and environment play a vital role. It could affect the entire body, selected systems or selected organs and an interplay between genetic makeup with environmental factors and the self-antigen presented for recognition controls which organ or system of the body that will become the target of the immune system [32, 33].
The precision medicines of the following autoimmune diseases are discussed below:
Multiple Sclerosis
Myasthenia Gravis
Pernicious Anemia
Rheumatoid Arthritis
Sjogren Syndrome
Lupus Erythematosus
Type 1 Diabetes
Multiple sclerosis is an inflammatory/autoimmune disorder that selects the myelin in the central nervous system which is capable of affecting patients of all age and causing neurologic disability when not adequately managed [34, 35]. More than 200 loci have been identified as an independent contributor to the pathogenesis of multiple sclerosis [36]. Multiple sclerosis is usually diagnosed between age 30 and 50 in most patients and occurs more often in females than male. The best way to understand the pathogenesis of multiple sclerosis is to address it from a multifactorial perspective with a model that proposes the interaction among genetic, epigenetic, infectious, dietary, climatic, or other environmental effects, together with sunlight exposure, and smoking. These interacting factors leads to self-intolerance and depreciation of immune homeostasis in the central Nervous system [34]. The brain and spinal cord tissues get infiltrated by stimulating peripheral mononuclear cells, and this leads to the loss of myelin, gliosis, which often leads to neurological dysfunction. Two primary approach of treatment has been given to the patient with multiple sclerosis due to the autoimmune model of the pathogenesis of such disease [34]. The former treatment is the use of global immunosuppressive agents which are aggressive. At the same time, the latter is the use of more specific agents to target specific elements of the immune system.
The contribution of common variants to multiple sclerosis has been probed, and different HLA alleles variants have been modeled for their contribution to multiple sclerosis and were found to be almost as common in control as it is in the sample as it was observed that OR of the statistical analysis tends towards 1 with an increase in sample size [37]. Biomarkers are important in the genetic assessment of Multiple Sclerosis as they possess the ability to express diverse aspects of multiple sclerosis heterogeneity. They also help in the diagnosis, stratification, and disease course prediction, identification of beneficial therapies and development of a precise treatment based on the predicted treatment response. As of 2016, MRI has turned to the most appropriate tool in the diagnosis of MS. The recommendation for brain MRI is the use of 1.5 T field strength, but 3.0 T is deemed preferable. However, using 7 T field strength has been supported by recent evidence to detect central vein in brain lesion of MS patients, but this can also be depicted using T2-weighted sequences at 3 T which help in the differentiation from microangiopathic lesions. The use of MRI for the diagnosis of MS seems simplified but its complexity sets in the differentiation of MS from other disease conditions like neuromyelitis optical spectrum disorders (NMOSD) which also has short spinal cord lesion at the onset. T2-weighted and contrast-enhanced T1-weighted brain MRI are recommended for the monitoring of disease progression while MRI of the spinal cord is not encouraged. Other than the MRI biomarkers there exist a few body fluid biomarker which could mark different stages of MS disease and differentiate each step from other similar disease conditions [34].
Body fluid biomarkers can be divided into three main groups, including those marking the early phase of MS, those associated with disease course and those associated with treatment response. Low vitamin D level in Cerebrospinal fluid is a marker of the initial stage of MS. Astrocyte-derived chitinase 3-like 1 (CHI3L1) in the CSF is also a prognostic marker of which an increased level of CHI3L1 in the CSF is a significant independent risk factor connected with the progression of disability in multivariate Cox regression models. Utilizing a proteomic approach and verification of result with ELISA confirmed that CHI3L1 would be the best predictors of the conversion to MS in CIS patients. CSF CHI3L1 level with MRI and age were the best predictors of MS risk in a multivariable analysis. Neurofilaments (NF-L) has also been implicated as a biomarker in the early phase of MS [36, 37].
Transcriptional regulator high-mobility group box protein 1 help differentiates patients with relapse-onset MS from patients from primary progressive MS. Proteomic studies show that two isoforms of vitamin D-binding protein and apolipoprotein E permit discrimination between MS patients with aggressive and benign disease courses [36]. During the disease course, calcium-binding protein secretogranin-1 is decreased in the CSF when compared with the early phase of MS. Stable MS patients, when compared with relapsing patients, possess an increase in B cell activating factors in their plasma samples. Solute carrier family 9, subfamily A (SLC9A9) is a biomarker associated with the non-response to IFN beta. Upregulation of the NLR family, pyrin domain containing 3 (NLRP3) inflammasome is also a biomarker for non-responsive IFN beta treatment. Biomarkers of glatiramer acetate response are feedback gene to complement 32 (RGC-32), FasL, and IL-21. Up-regulated mRNA expression levels of RGC-32 and FasL and reduced expression of IL-21 seen in peripheral blood cells from responders in contrast to non-responders forms the basis for the use of these biomarkers [34, 36, 37].
Myasthenia gravis (MG) is an autoimmune disease treated with chronic immunosuppression due to the actions of autoantibodies against the diverse structure of the neuromuscular intersection [38]. The variation of the patient’s response to treatment and the variation in side effects to such treatment is the justifying reason for the recognition of the biological markers to predict the effectiveness of each treatment in each patient. Presence of anti-AChR antibodies is a beneficial biomarker in the diagnosis of MG. Still, it cannot judge disease severity as no specific correlation was found between MG severity and anti-AChR antibodies level [39]. MiR-323b-3p, −409-3p, −485-3p, −181d-5p, and − 340-3p has been predicted and suggested as response biomarker to project immunosuppressive drug sensitivity in MG patients.
The miRNAs can be tested in the blood, which would make it a potent response biomarker for treatment response, and any patient detected not to respond as expected will be addressed to other treatments thereby increasing cost-effectiveness. MiR-323b-3p, −409-3p and − 485-3p were downregulated in Non-responding patients while miRNA-181d-5p, and − 340-3p were upregulated in the Non-responding patients [39, 40]. A significant association has been identified between patient’s response to azathioprine and two haplotypes, the TPMT3E haplotype in the thiopurine S-methyltransferase and a haplotype in the ATP-binding cassette sub-family C member 6 transporter. The glucocorticoid therapy non-responsive MG patients were found to possess a genetic variant in the secreted phosphoprotein 1 (SPP1) gene encoding osteopontin, which associates it with the non-responsive group [40].
Pernicious anemia (PA), is an autoimmune disease which results from a long-standing infection by
Rheumatoid arthritis (RA) is a heterogeneous disease which can range from mild, self-limiting arthritis to fast progressive joint damage. It is triggered by a complex interaction between the human genetic makeup and the environment. Still, both environmental influence and genetics cannot exhaustively account for the heterogenic clinical features of the disease condition. It is also characterized by synovial hyperplasia and joint destruction, which can lead to joint deformity or [42].
Currently, the treatment of RA is based on the control of inflammation with which an effective therapy that comes early ensures a drastic reduction in the risk of joint damage, mortality and disability. As of 2017, major researches has focused on the identification of biomarkers that can predict patient’s response to only Methotrexate (MTX) which is the first non-biologic therapeutic agent administered. Also, TNF inhibitors (TNFi) has been established to be ineffective in about 30% of patients but remains the first choice of available biologic therapeutic agents. Solute carrier family 19 member 1 (SLC19A1) gene possess the most consistent and relevant evidence. It is one of the many transport carriers that allow the transport of MTX into the cell [43].
Anti- CCP antibodies a genomic marker associated with poor prognosis as it relates to the severity of disease and the extent of damage caused on the joint, HLA-DRB1 alleles coding for shared epitope is another marker for severity in RA [44].
Sjögren’s syndrome (SS) is a form of B cell hypersensitivity which is manifested in the formation of excess autoantibodies and a strong propensity for NHL of B cell emergence [45]. About 5% of patients of primary SS are at risk of lymphoma development. However, it is vital to have a specific biomarker to identify such patient early to be able to monitor and detect early and select appropriate therapy. The diagnostic biomarkers will guide in the diagnosis, and the predictive biomarkers are meant to show another aspect of clinical decision. Cytopenias is an established prognostic biomarker for the development of lymphoma [46]. A lot of proposed biomarkers in the assessment of SS are yet to be confirmed in more extensive studies before adoption into clinical use [47].
The systemic lupus erythematosus (SLE) has a broad spectrum of signs and symptoms which varies among patients and involves numerous organs with skin, joints, kidneys, lungs and CNS included. It is a chronic inflammatory autoimmune disease [48]. An association has been established between SLE and human leukocyte antigen (HLA) haplotypes (HLA-DR3; DR9; DR15; DQA1*0101 especially). The extensive association has also been found between vitamin D matching up with serum concentrations and vitamin D-receptor genomic binding domains [49].
The type 1 diabetes (T1D) takes place as a result of autoimmune beta-cell destruction, which leads to insufficient production of insulin and results in hyperglycemia [50]. Although the role of precision medicine in type 1 diabetes is not well defined, patient with T1D severity varies with difference in their pancreatic autoantibodies profile and the rate at which their beta cells destroy [51].
In genetic studies (an important feature of precision medicine), identification of over 50 genetic signals in notably HLA region has been found to influence T1D predisposition [52]. The diagnostic biomarkers (serum biomarkers) use in the diagnosis of T1D includes the combination of glucose, C-peptide, glycated molecules and autoantibodies established for T1D. Still, these molecules often mark the late stage of the disease [53].
So far, advance in genomic research introduces the administration of islet autoantigens or peptides into a recipient with the risk of T1D; these studies suggest promising changes in immune regulation of islet autoimmunity. The challenges remain dosing frequency, dosage, route of administration, and adjuvants use.
A systemic follow up of variant genes like the TNFRSF1A that is connected with multiple sclerosis risk should be closely investigated by researchers. This gene could give an essential perception of the etiology of multiple sclerosis and new treatment strategies.
Myasthenia gravis-related loci may display their involvement in the pathogenesis of immune disease by increasing immune response, repression of the mechanism involved in immune suppression, alteration of procedure that differentiates between autologous and heterologous molecular configuration through immune tolerance, therefore investigations into Single nucleotide polymorphisms (SNPs) in the general population that is associated with Myasthenia gravis will improve diagnosis, therapy and its outcome.
Genome editing technologies have been used with a degree of success in the treatment of sickle cell disease and β-thalassemia, this could be introduced into the precise treatment of pernicious anemia with proper study of the gene encoding for mitochondrial transport of vitamin B12.
Rheumatoid arthritis research should focus on discovering more associated genes and their resultant effects. Transcriptomic and epigenomic strategies should also be used in discovering biomarkers of response to treatments and pathways that are related to therapies. Integration of genetic, clinical and environmental data are also crucial in achieving the aim of precision medicine in the treatment of rheumatoid arthritis.
Selection of novel treatments could be achieved for sjogren syndrome by identification of genetic risk factors like that of profound interferon signaling pathway by IRF5 and STAT 4 genes.
Prevention of systemic lupus erythematosus by assaying genetic profile, developing new biomarkers of immune activation and alteration is the precise future treatment of this condition.
Investigations into genes and pathways of type 1 diabetes may reveal on time the pathogenic role of the destruction of β-cell and production of clinical disease by the innate and adaptive immune system. Type 1 Diabetes Genetics Consortium (T1DGC) international have resources that could help in diagnosis, interventions, and monitoring outcomes of treatment of type 1 diabetes.
As the era of ‘Big Health Data’ continues, it is essential for the diagnosis, prognosis and treatment monitoring efforts on autoimmune diseases to take advantage of the data and different machine learning and deep learning algorithms to establish patterns and clusters within the disease groups. This will help in the identification of more relevant biomarkers and also help in the easy transition of biomarker researches to the bedside.
Indeed, the application of precision medicine in autoimmune diseases depends on the progress of next-generation sequencing program, which at the same time will strive to provide not only a whole-exome, or transcriptome, but at an exact process that is cost-efficient.
The information provided by the Genomics data is an indispensable component of precision medicine as it holds the key to the explanation in individual variability and evolution [54]. But, the clinical use of genomic data still needs to be improved on to overcome challenges stated by Kim et al. [55] like:
The incongruity between the form of genomic and clinical information: as a result of extensive (several tens of gigabytes of sequence) data in the genomic data, clinical data cannot be processed in the clinical practice without additional processing [55, 56].
The difference in the properties of genomic data and observational data used in the clinical settings: given that the genomic workflows hold a large number of data, data obtained from this workflows is undoubtedly different from systems parallel to the clinical plan [57].
Difficulty in mapping the genomic and clinical data for medical interpretation: as seen in the case of targeted sequencing, where most data are processed before medical analysis [58].
Also, there is no international validation for biomarkers in use; there is a need for international collaboration to validate biomarkers presently in existence.
Overcoming these challenges will open up more opportunities for the use of genomic data in clinical practices.
The authors declare no conflict of interest.
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Extreme weather conditions and changes in humidity rates significantly affect the concrete compressive strength development. Concrete as one of the substantial material used in residential buildings and infrastructures is subjected to a massive strength change under extreme weather conditions. For understanding, the different concrete’s behavioral aspects, various commercial cement types under different temperatures, and humidity rates are investigated in this chapter. The experiments are aimed to investigate the concrete strength development over time when the material is cast at lower to mild temperatures and different humidity index rates. Results show that reducing the curing temperature more than 15° could result in 20% reduction in total compressive strength, while decreasing humidity rates by 50% leads to less than 10% drop in ultimate strength. To understand the strength developing process, maturity tests are conducted. It is shown that concrete is not able to reach to the expected ultimate strength if the temperature is significantly low regardless of curing time. The effect of temperature change during the curing process is more tangible on strength development compared to cement type and humidity rate values.",book:{id:"8757",slug:"compressive-strength-of-concrete",title:"Compressive Strength of Concrete",fullTitle:"Compressive Strength of Concrete"},signatures:"Alireza Farzampour",authors:null},{id:"51720",doi:"10.5772/64574",title:"Microstructure of Concrete",slug:"microstructure-of-concrete",totalDownloads:4908,totalCrossrefCites:16,totalDimensionsCites:21,abstract:"Concrete is a composite material that consists of a binding medium and aggregate particles and can be formed in several types. It may be considered to consist of three phases: a cement paste, the aggregate, and the interfacial transition zone (ITZ) between them. In addition to ordinary Portland cement, the essential components of the base of concrete are aggregates and water. For practical requirements, additives and admixtures can be added to these raw materials to improve some desirable characteristics. The following requirements should be considered in producing high performance concrete (HPC): (i) low water/cement (w/c) ratio; (ii) fine aggregate; (iii) large quantity of mineral additives, silica fume, and fly ash; (iv) high dosage of superplasticizer; and (v) high-pressure steam curing. The microstructure of high performance concrete (HPC) is more homogenous than that of normal concrete (NC) due to the physical and chemical contribution of the additives (silica fume and fly ash) as well as it is less porous due to reduced w/c ratio with the addition of a superplasticizer. Inclusion of additives (individually or in combination) helped in improving the strength and durability of concrete mixes due to the additional reduction in porosity of cement paste and an improved interface between it and the aggregate.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Ameer A. Hilal",authors:[{id:"180518",title:"Dr.",name:"Ameer",middleName:null,surname:"Hilal",slug:"ameer-hilal",fullName:"Ameer Hilal"}]},{id:"51861",doi:"10.5772/64779",title:"Concretes with Photocatalytic Activity",slug:"concretes-with-photocatalytic-activity",totalDownloads:2860,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"This chapter is a short review about the modified concretes with photocatalytic activity. In the beginning, the photocatalysis process is explained; the authors are focused on the mechanism of organic contamination and nitrogen oxide decomposition. Next the three main methods for concretes modification are presented: the first group is when the concrete is covered by thin layer of TiO2 materials, e.g., paints or TiO2 suspensions. The second group is the concretes with thick layer of photoactive concrete on the top. The third group constitutes concretes modified in mass with TiO2. The two main methods for photocatalytic activity of the modified concrete determination were shown: an air purification by a nitrogen oxide decomposition and the self-cleaning properties by dyes decomposition. Also in this chapter the mechanical properties of the modified concrete are presented. In the end, the examples of the buildings made of photocatalytic concretes are shown.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Magdalena Janus and Kamila Zając",authors:[{id:"180824",title:"Associate Prof.",name:"Magdalena",middleName:null,surname:"Janus",slug:"magdalena-janus",fullName:"Magdalena Janus"}]},{id:"64801",doi:"10.5772/intechopen.82489",title:"Bitumen and Its Modifier for Use in Pavement Engineering",slug:"bitumen-and-its-modifier-for-use-in-pavement-engineering",totalDownloads:1572,totalCrossrefCites:5,totalDimensionsCites:12,abstract:"This chapter focuses on bitumen specifically. This chapter consists of several parts that can be mentioned, including the history of the appearance of bitumen and the types of constituent elements, as well as its mechanical properties and chemical structure and its thermal sensitivity. In all parts, the effects of bitumen on asphalt are discussed. In the following sections, the bitumen modification mechanism, polymer modifiers, and their behavior on the bitumen resistance to asphalt failures are also discussed. This chapter is very suitable for students and researchers interested in improving polymerization asphalt and bitumen and will help them to carry out research and concepts.",book:{id:"8412",slug:"sustainable-construction-and-building-materials",title:"Sustainable Construction and Building Materials",fullTitle:"Sustainable Construction and Building Materials"},signatures:"Mehrdad Honarmand, Javad Tanzadeh and Mohamad Beiranvand",authors:[{id:"268734",title:"M.Sc.",name:"Mehrdad",middleName:null,surname:"Honarmand",slug:"mehrdad-honarmand",fullName:"Mehrdad Honarmand"},{id:"271251",title:"Prof.",name:"Javad",middleName:null,surname:"Tanzadeh",slug:"javad-tanzadeh",fullName:"Javad Tanzadeh"}]},{id:"64787",doi:"10.5772/intechopen.82525",title:"A Decade of Research on Self-Healing Concrete",slug:"a-decade-of-research-on-self-healing-concrete",totalDownloads:1484,totalCrossrefCites:7,totalDimensionsCites:9,abstract:"The main findings of a decade of research on the design and development of the first self-healing concrete are summarized in this chapter. The autonomous healing concept is introduced, and plethora of design campaigns is enlisted. Healing agent encapsulation and agent tubes vascular networks are reported as the most efficient healing configurations for laboratory-scale and real-size applications, respectively. Crack formation, closure after healing and further damage are phenomena tracked by using advanced experimental monitoring methods and their performance is critically revised. The effect of self-healing technology on concrete mechanical response, durability and long-term response to damage are critically discussed. The study contributes to the open discussion in the scientific research community regarding self-healing concrete upscaling feasibility and finally it aims to contribute as a base for the future studies dealing with concrete design optimization.",book:{id:"8412",slug:"sustainable-construction-and-building-materials",title:"Sustainable Construction and Building Materials",fullTitle:"Sustainable Construction and Building Materials"},signatures:"Eleni Tsangouri",authors:[{id:"263163",title:"Ph.D.",name:"Eleni",middleName:null,surname:"Tsangouri",slug:"eleni-tsangouri",fullName:"Eleni Tsangouri"}]}],mostDownloadedChaptersLast30Days:[{id:"70605",title:"Designing a Tunnel",slug:"designing-a-tunnel",totalDownloads:2790,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"Designing a tunnel is always a challenge. For shallow tunnels under cities due to the presence of buildings, bridges, important avenues, antiquities, etc. at the surface and other infrastructures in the vicinity of underground tunnels, parameters like vibrations and ground settlements must be tightly controlled. Urban tunnels are often made in soils with very low values of overburden. Risks of collapse and large deformations at the surface are high; thus negative impact on old buildings are likely to occur if appropriate measures are not taken in advance, when designing and constructing the tunnel. For deep tunnels with high overburden and low rock mass properties, squeezing conditions and excessive loads around the excavation can jeopardize the stability of the tunnel, leading to extensive collapse. The aim of the chapter is to give details on advance computational modelling and analytical methodologies, which can be used in order to design shallow and deep tunnels and to present real case studies from around the world, from very shallow tunnels in India with only 4.5 m overburden to a deep tunnel in Venezuela with extreme squeezing conditions under 1300 m overburden.",book:{id:"7690",slug:"tunnel-engineering-selected-topics",title:"Tunnel Engineering",fullTitle:"Tunnel Engineering - Selected Topics"},signatures:"Spiros Massinas",authors:[{id:"295762",title:"Dr.",name:"Spiros",middleName:null,surname:"Massinas",slug:"spiros-massinas",fullName:"Spiros Massinas"}]},{id:"70990",title:"Engineering Geology and Tunnels",slug:"engineering-geology-and-tunnels",totalDownloads:1991,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Currently, knowledge and understanding of the role of geological material and its implication in tunnel design is reinforced with advances in site investigation methods, the development of geotechnical classification systems and the consequent quantification of rock masses. However, the contribution of engineering geological information in tunnelling cannot be simply presented solely by a rock mass classification value. What is presented in this chapter is that the first step is not to start performing numerous calculations but to define the potential failure mechanisms. After defining the failure mechanism that is most critical, selection of the suitable design parameters is undertaken. This is then followed by the analysis and performance of the temporary support system based on a more realistic model. The specific failure mechanism is controlled and contained by the support system. A tunnel engineer must early assess all the critical engineering geological characteristics of the rock mass and the relevant mode of failure, for the specific factors of influence, and then decide either he or she will rely on a rock mass classification value to characterise all the site-specific conditions. Experiences from the tunnel behaviour of rock masses in different geological environments in Alpine mountain ridges are presented in this chapter.",book:{id:"7690",slug:"tunnel-engineering-selected-topics",title:"Tunnel Engineering",fullTitle:"Tunnel Engineering - Selected Topics"},signatures:"Vassilis Marinos",authors:[{id:"298713",title:"Associate Prof.",name:"Vassilis",middleName:null,surname:"Marinos",slug:"vassilis-marinos",fullName:"Vassilis Marinos"}]},{id:"51720",title:"Microstructure of Concrete",slug:"microstructure-of-concrete",totalDownloads:4905,totalCrossrefCites:16,totalDimensionsCites:21,abstract:"Concrete is a composite material that consists of a binding medium and aggregate particles and can be formed in several types. It may be considered to consist of three phases: a cement paste, the aggregate, and the interfacial transition zone (ITZ) between them. In addition to ordinary Portland cement, the essential components of the base of concrete are aggregates and water. For practical requirements, additives and admixtures can be added to these raw materials to improve some desirable characteristics. The following requirements should be considered in producing high performance concrete (HPC): (i) low water/cement (w/c) ratio; (ii) fine aggregate; (iii) large quantity of mineral additives, silica fume, and fly ash; (iv) high dosage of superplasticizer; and (v) high-pressure steam curing. The microstructure of high performance concrete (HPC) is more homogenous than that of normal concrete (NC) due to the physical and chemical contribution of the additives (silica fume and fly ash) as well as it is less porous due to reduced w/c ratio with the addition of a superplasticizer. Inclusion of additives (individually or in combination) helped in improving the strength and durability of concrete mixes due to the additional reduction in porosity of cement paste and an improved interface between it and the aggregate.",book:{id:"5214",slug:"high-performance-concrete-technology-and-applications",title:"High Performance Concrete Technology and Applications",fullTitle:"High Performance Concrete Technology and Applications"},signatures:"Ameer A. Hilal",authors:[{id:"180518",title:"Dr.",name:"Ameer",middleName:null,surname:"Hilal",slug:"ameer-hilal",fullName:"Ameer Hilal"}]},{id:"77899",title:"Review of Existing Methods for Evaluating Adhesive Bonds in Timber Products",slug:"review-of-existing-methods-for-evaluating-adhesive-bonds-in-timber-products",totalDownloads:248,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Gluing is an integral part of the majority of production processes in the timber industry. The effectiveness of adhesive application, glue bond development and glue penetration into the wood structure is becoming more and more important as more structural glued timber products are used in construction and other applications. The continued increase in utilisation of mass timber products (MTPs) such as CLT, glulam and LVL in tall timber buildings requires an accurate and in-depth understanding of adhesive roles and their performance effectiveness during the life span of any of those products in relation to the type of loading applied, environmental effects (e.g. RH and temperature) and in-service condition of elements (e.g. exposure to major wet events and degradation from decay). This review aims to provide a comprehensive summary of existing imaging and other visualisation methods used to assess the glue line properties and examine the performance of glue lines in relation to factors such as species, product type and environmental conditions during manufacture and in-service life.",book:{id:"10584",slug:"engineered-wood-products-for-construction",title:"Engineered Wood Products for Construction",fullTitle:"Engineered Wood Products for Construction"},signatures:"Maryam Shirmohammadi and William Leggate",authors:[{id:"346973",title:"Dr.",name:"Maryam",middleName:null,surname:"Shirmohammadi",slug:"maryam-shirmohammadi",fullName:"Maryam Shirmohammadi"},{id:"426650",title:"Dr.",name:"William",middleName:null,surname:"Leggate",slug:"william-leggate",fullName:"William Leggate"}]},{id:"78315",title:"Engineered Wood Products as a Sustainable Construction Material: A Review",slug:"engineered-wood-products-as-a-sustainable-construction-material-a-review",totalDownloads:438,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Engineered wood products are considered as best building materials due to environmentally friendly. Huge change to the way in which wood has been utilized in primary application of construction in the course of the most recent 25 years are in light of decreased admittance to high strength timber from growth forests, and the turn of events and creation of various new design of manufactured wood products. Engineered wood products are available in different variety of sizes and measurements like laminated veneer lumber, glued laminated timber, finger jointed lumber, oriental strand board etc. It is utilized for rooftop and floor sheathing, solid structure, beams and the hull of boats. This review objectively explores not only the environmental aspects of the use of different engineered wood composites as a building material, but also their economic aspects, to understand their effect on sustainability.",book:{id:"10584",slug:"engineered-wood-products-for-construction",title:"Engineered Wood Products for Construction",fullTitle:"Engineered Wood Products for Construction"},signatures:"Ranjana Yadav and Jitendra Kumar",authors:[{id:"335083",title:"Dr.",name:"Jitendra",middleName:null,surname:"Kumar",slug:"jitendra-kumar",fullName:"Jitendra Kumar"},{id:"354856",title:"Dr.",name:"Dr Ranjana",middleName:null,surname:"Yadav",slug:"dr-ranjana-yadav",fullName:"Dr Ranjana Yadav"}]}],onlineFirstChaptersFilter:{topicId:"284",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81503",title:"The Data Representations of a Building Project: BIM Model, and IFC or IFCXML Data Standard",slug:"the-data-representations-of-a-building-project-bim-model-and-ifc-or-ifcxml-data-standard",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.104580",abstract:"Building regulations in the construction industry are legal documents written in human language. These are interpreted and implemented by people and generally controlled by local governments. Traditional building regulation control and supervision methods emerge as a time-consuming and error-prone process for architects, engineers, and public authorities. Therefore, BIM\\'s effective building regulation control is considered a promising field of study in the construction industry. Automated Code Compliance Checking (ACCC) method is a rule-based method that provides simultaneous control of the computer’s building regulations. ACCC takes into account the characteristics of the building elements and related building regulations. BIM is recognized as the most effective platform for information exchange of building projects in the construction industry. It supports the development of various software. It facilitates automated or semi-automated ACCC of the building projects for compliance with building regulations and standards for the participants involved in the building production process. The data of the building project are represented in two ways in the ACCC. These are BIM Model, and IFC or IFCXML Data Standard. In this study, the BIM, IFC, and IFCXML representations of the building project data were explained over the sample housing project in the ACCC process.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Murat Aydın"},{id:"81506",title:"Bentonite Clay Modified Concrete",slug:"bentonite-clay-modified-concrete",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.103803",abstract:"Replacing cement with pozzolanic materials to some extent in construction is found to be one of the sustainable approaches in the construction industry. Pozzolanic materials of industrial origin like fly ash and Ground Granulated Blast furnace Slag will have to be replaced with natural pozzolanic materials once the world moves towards renewable energy sources. Bentonite is one such pozzolanic clay material that is rich in SiO2 content. A little research was made to assess the performance of bentonite modified concrete. Based on those, an improvement in the fresh, hardened, durability properties was reported. This chapter presents the current scenario on the development of bentonite modified concrete. It also reviews the literature about the physical & chemical properties of bentonite, bentonite blended cement mortar, bentonite modified cement concrete, and reinforced concrete. The history and development of Bentonite modified concrete were also briefly presented in this chapter.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Metta Achyutha Kumar Reddy and Veerendrakumar C. Khed"},{id:"81381",title:"Oil Contaminated Sand: Sources, Properties, Remediation, and Engineering Applications",slug:"oil-contaminated-sand-sources-properties-remediation-and-engineering-applications",totalDownloads:26,totalDimensionsCites:0,doi:"10.5772/intechopen.103802",abstract:"Oil leakage during the exploration, production, and transportation of crude oil is a significant issue worldwide because crude oil spills severely impact the physical and chemical properties of the surrounding soil. A range of remediation methods for oil-contaminated soil is recommended, consisting of sand washing, bioremediation, electro-kinetic sand remediation, and thermal desorption; however, none are cost-effective. To find a suitable alternative remediation method, oil-contaminated sand utilisation in construction was considered. Several researchers found that oil contamination generally has an adverse effect on the mechanical properties of sand, but certain levels of contamination have beneficial effects on some of the important properties of the sand and its produced concrete. This chapter reviews the main sources of oil contamination and the existing remediation methods for this waste material. It analyses the different factors that affect the properties of oil-contaminated sand and concrete, including the type of crude oil and permeability of sand, like its properties, absorption, chemical composition, and spillage quantity. Furthermore, the intensive evaluation results of light crude oil effects on the geotechnical properties of fine sand, cement mortar and concrete were presented. Potential applications for oil-contaminated sand were also identified for the re-use of this material in engineering and construction.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Rajab Abousnina and Rochstad Lim Allister"},{id:"81175",title:"Thermal Conductivity and Mechanical Properties of Organo-Clay-Wood Fiber in Cement-Based Mortar",slug:"thermal-conductivity-and-mechanical-properties-of-organo-clay-wood-fiber-in-cement-based-mortar",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.102321",abstract:"This paper orientated to study the compressive resistance and thermal conductivity of compressed and stabilized clay blocks in the cement matrix. The effect of the content of wood fiber (WF) became studied as a reinforcement material in cement mortars. The porosity, compressive energy, thermal conductivity and composite of cement hydration had been investigated. The addition of NFC suggests a very good pore reduction, and the fine result becomes acquired with the emulsion of a combination incorporating 2%wt of WF inside the presence of an anionic surfactant (SDBS). The results revealed that used in this study were a mix of water with ordinary portland cement and organo-clay (OC) modified with Cetyltrimethylammonium bromide at water-to-solid ratios 1%. The effect depending on w/s ratio of OC used samples with cement substitution for organoclay showed from 2% higher compressive strength results than that of the plain cement paste and a decrease of the thermal conductivity by addition of 2%wt of WF from 2.26 to 0.8 W/m °C. It was also observed that with increasing w/s ratio higher amount of cement can be replaced by OC. These analyses have revealed that the presence of WF promoted the hydration, by producing more portlandite and calcium silicate gel.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Fadhel Aloulou and Habib Sammouda"},{id:"80651",title:"The Effects of Mill Conditions on Breakage Parameters of Quartz Sand in the District of Şile on the Black Sea Coast of İstanbul",slug:"the-effects-of-mill-conditions-on-breakage-parameters-of-quartz-sand-in-the-district-of-ile-on-the-b",totalDownloads:54,totalDimensionsCites:0,doi:"10.5772/intechopen.102554",abstract:"Casting, glass, ceramic, construction, plastic, dyeing, and abrasive industries are the main consumption areas of quartz sand, which are formed as a result of the weathering of igneous metamorphic rocks. In such industries, it is very important to select the correct ball size in order to grind the raw material to the desired particle size in optimum time. In this study, the changes in the specific rate of breakage of the quartz sand sample were investigated by using alloy steel balls of five different sizes. For this purpose, three different mono-size samples were prepared according to 4√2 series in the range of 0.090–0.053 mm. The quartz sand prepared in these three intervals was ground with 6.35, 7.94, 9.52, 12.70, and 19.05 mm alloy steel balls for different durations. The specific rate of breakage values was obtained from the particle size distributions acquired after various grinding periods. As a result of grinding tests, an increase in the rate of breakage is observed due to the increase in ball diameter.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Serhan Haner"},{id:"80288",title:"The Role of Sand in Mortar’s Properties",slug:"the-role-of-sand-in-mortar-s-properties",totalDownloads:58,totalDimensionsCites:0,doi:"10.5772/intechopen.102489",abstract:"Mortars are diachronic composite materials used in masonry construction to serve multiple roles. Their durability and esthetic harmonization in constructions of the different eras were the reasons why numerous research works have been realized over recent decades. Each time, the role of the mortars’ components revealed significant pieces of information on the technology used. Despite the indisputable role of the binders on the mortar’s quality, aggregates of different characteristics had a significant role in the behavior of mortars. The addition of aggregates to a binding system in mortars technology has proved to confer technical advantages as they contribute to volume stability, durability, and structural performance. Apart from the different types of aggregates, as their mineralogy and origin are concerned, the volume content in the mixture, the maximum size, and their gradation influences the structure of a binder—aggregate mixture and the performance of mortars overall. In the present article, the diachronic presence of mortars is presented. The role of aggregates is emphasized to understand their impact on the longevity and durability of the mortars.",book:{id:"11186",title:"Sand in Construction",coverURL:"https://cdn.intechopen.com/books/images_new/11186.jpg"},signatures:"Maria Stefanidou and Parthena Koltsou"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. He is also a reviewer and a member of editorial boards of a number of international journals.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorTwo:{id:"484980",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Garbacz",slug:"katarzyna-garbacz",fullName:"Katarzyna Garbacz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003St8TAQAZ/Profile_Picture_2022-07-07T09:45:16.jpg",biography:"Katarzyna Maria Garbacz, MD, is an Associate Professor at the Medical University of Gdańsk, Poland and she is head of the Department of Oral Microbiology of the Medical University of Gdańsk. She has published more than 50 scientific publications in peer-reviewed journals. She has been a project leader funded by the National Science Centre of Poland. Prof. Garbacz is a microbiologist working on applied and fundamental questions in microbial epidemiology and pathogenesis. Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:303,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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