\r\n\tAn update on clinical manifestations, their assessment, monitoring, and imagiology, including peripheral arthritis, enthesopathy, and extra-articular findings, and, the differential diagnosis with other diseases which evolves with axial and peripheral calcifications will be provided.
\r\n\r\n\t
\r\n\tAn important component of this book must be dedicated to the more recent treatments namely with biologic therapies but focusing also on new small molecule inhibitors and experimental therapies.
“Kidnapping the bride” of Sasak wedding practices puts as a record by the Ministry of Education and Culture as Lombok West Nusa Tenggara customs [1]. This practice is also supported by the government as a code of conduct of Sasak people [2]. Lukman [3] strengthens the position of “kidnapping the bride” in Sasak traditional culture. The practice of “kidnapping the bride,” from the independence era until
The practice of “kidnapping the bride” serves an important theme of the Indonesian novel Lombok. The theme is firstly portrayed by Nadira Khalid in the novel
Both novels represent the practice of “kidnapping the bride” differently.
Some studies [6, 7, 8, 9, 10] reveals that ethnic representation in contemporary Indonesian literary studies is assumed to be a local wisdom. These studies ignore the political movements of local people who at some stage are no longer local. Ethnic writers in the United States carry out social and political movements so that ethnic groups have important positions, both in literature and politics [11]. Lombok experiences this situation. From independence until the early reformation era, Lombok is led by a governor from Java. It is only in 2003 that the native son is elected as governor. Sasak ethnic identity has begun to emerge in the 2000s. The Indonesian literary production of Lombok is part of an ethnic revival to sound Sasak cultural identity.
\nIndonesian Literature of Lombok emerges as a meeting point of two studies, namely Lombok studies and contemporary Indonesian literary studies. Novel
This article applies Stuart Hall’s representation theory. Hall’s representation theory serves to theorize the practice of Lombok Sasak “kidnapping the bride.” It accommodates the context of contemporary Indonesian literature with Lombok as its ethnic issue. This practice also delivers a sign and a discourse. As a sign, “kidnapping the bride” is constructed as semiotic analysis in the novel. As a discourse, “kidnapping the bride” is constructed academically by several studies. The novel serves as primary data source while some studies of “kidnapping the bride” and discourse about Lombok supplies secondary data sources. The first data source is in the form of lingual units in the form of sentences or paragraphs that provide information about the practice of “kidnapping the bride.” The second data source is in the form of discursive statements from several studies of “kidnapping the bride” and Lombok. The data source delivers the perspective of Sasak people living in the Sasak culture of Lombok. The first and second analysis applies semiotic analysis and discourse. The analysis conveys the experience of researchers as Sasak people taken from the researcher’s experience. The meaning of “kidnapping the bride” in a novel is as a dialog in academic discourse.
\nThe “kidnapping the bride” study conducted by Wijaya [13] and Zuhairini [14] positions “kidnapping the bride” as a culture that needs to be criticized. Both interpret
In cultural studies, the practice of “kidnapping the bride” was conceptualized as a result of acculturation of Sasak and Bali [15]. “Kidnapping the bride” is not a native Sasak culture, but acculturation with Balinese culture [4]. Therefore, the development of sees “kidnapping the bride” experiences codification with Islamic and state law. Lukman [16] sees “kidnapping the bride” from a legal perspective. According to him, there are three laws in the “kidnapping the bride” tradition, namely religious, customary and state law ([16], 427). In the perspective of Islamic law, Basriadi [17] reviews marital law of different classes, aristocratic women with non-aristocratic men, not contrary to customary law. If in practice, there are parents who do not want to marry off their children to men of different classes, then the bride and groom are married by the guardian of the judge. Aminullah [18] explaines that the practice of “kidnapping the bride” has been modified, for example in the tradition of drinking alcohol in the process of collusion. Mahayanti [19] sees the tension of Islamic law and customary law in terms of giving
Krulfeld [20] distinguishes Sasak society based on the type of religiosity.
Asnawi [27] emphasizes the position of the teacher as a refinement of Islamic teachings. Tuan Guru becomes the main agent of the acculturation of Islamic values in the Sasak culture [28]. The important position of
This novel presents a noble man and
As time passes from so many choices of Mamiqnya, Raihan is proposed by young nobles from the village of Gede. Handsome, handsome, smart young man. It is reported that the son of a
In Lombok culture,
Raihan is forced to choose and accept an arranged marriage with Lalu Said. The choice is taken in order to maintain the honor of his family. That choice is a manifestation of Raihan’s disdain for her love for Habib. In order to maintain that honor, Raihan choses to betray Habib’s love, an ordinary man,
“Look, sir, if we want to make peace with our family, this father as Habib’s parents, must take responsibility for several legal agreements, and sanctions if they are violated. Then, Raihan is asked to tell about her journey, but it is strange to Habib that what is told. It cannot help him to get out from the legal problem, because Raihan’s testimony is not in favor of him, in the love they were fighting for. Shed tears of sadness. How have our fathers heard the confession of this girl, then is there anyone capable of defending Habib? “That’s not right sir, that’s wrong, everything she says is her parents’ orders. “.
\n“Calm down!” The policeman snapped.
\n“Sir! How about the word peace we have discussed earlier, “asked his father. “Hearing all the stories and confessions of our girls is enough to get here and we don’t need peace money from you guys!”
\n“Alright sir, whatever the responsibility I am ready, even though I have to be in jail.
Raihan gives false testimony, so the act of carrying Raihan serves as a criminal act. Though both of them agree to elope to avoid arranged marriages Raihan with Lalu Said, the son of the noble
Raihan’s love for Habib is now a mere lie that he must throw away in his mind. However, all that is useless, it’s so hard for him to just forget it all. The betrayal of love and disappointment he gave is the most beautiful gift that is sweet at first, then bitter at the end. His best friend Nasir visits him that afternoon after a few days ago came to him. This time Nasir arrives early. From the jail, Habib comes out in a white prisoned costume bearing number 07. The iron door is opened by officers then Habib comes out with a listless face ([34], p. 49).
\nThe quote shows that Habib finally becomes a prisoner. His love has taken him to prison. The love he believes has become a lie. Betrayal love is the most beautiful gift, because that’s all that’s left. After the disappointment there is no chance to change the betrayal. What remains is memories. Betrayal is not without consequences for Raihan himself. Both are imprisoned. Habib is imprisoned in the jail and Raihan is imprisoned by tradition. Both prisons are equally limiting their actions. But the prison occupied by Raihan is a prison of eternal tradition in his life. The prison that is occupied by Habib is a prison that has physical strength, while Raihan is a prison that has power that is not only physical. Faruk [37] called it a prison because of formal normative or ethical legal issues, while the prison occupied by Raihan is cultural and philosophical because it involves the suppression of freedom of choice. Habib can only come out after he has lived according to established rules, while Raihan can only get out of traditional prison after his family dies and his marriage ends in divorce.
\nHer face is covered with sorrow, her thin body told a bitter truth. She sits not in her husband’s bed, she does not live in her in-laws’ house but she is in her house. Raihan is now veiled in gloom, she returns to her umma while her mother has passed away for a year. She returned home with full of regret and accepted his new status as a widow, lying. Guilt and betrayal of love still make an impression in her heart. Her beauty is faded even though there are still beautiful lines on her face. The blue eyes look sad, while his heart continues to whimper with prolonged injury ([34], 66).
\nRaihan divorces her husband because she is unable to give her husband offspring. Raihan is widowed. Her widowed status is unable to get her out of suffering. She still feels hurt, sorry, and guilty. Her disdain for Habib still leaves an imprint on her heart and hurt him all his life before he received an apology from Habib. Her injured heart is followed by shortness of breath and lung cancer. She dies after meeting with Habib.
\nShortness of breath and cancer undermines her lungs, Raihan is only able to lie on the bed, breathing hard. Ummi in surrender faithfully goes side by her side. While being close to her death, the verses of the Koran from the Surah Yasin continue to be recited by her family and close relatives. Her curling eyelashes look wet as she endures pain, the patient and faithful rays of her face radiate happily in the arms of her beloved Habib. The howling sound of dogs gripped together with a smile that finally silenced then the tired body stiffened. Her mom cries helplessly staring at her only daughter silently without a sound.
Raihan visits to the divine in accordance with her promise. She passes away after meeting with Habib. The meeting is at once a farewell for both.
\n“Kidnapping the bride” done by Habib and Baiq Raihan is not a custom event, but an abduction event. Therefore, “kidnapping the bride” is a criminal case. The novel positions this practice as a criminal act. Raihan is a victim and a witness who confirms that Habib kidnappes her. Though they love each other and they make the decision to do this practice together. If the novel positions Raihan in favor of Habib, then “kidnapping the bride” is a process of the Sasak wedding tradition. Habib is put in jail for kidnapping. Raihan testifies that she is kidnapped.
\n
Indonesian literature as a scientific discipline develops several paradigms in its studies of Indonesian literary works. The study of Indonesian literature in the 1990s to 2000s was dominated by structuralism [38]. Supriyadi saw the tendency of Indonesian literary studies at two universities, namely Gadjah Mada University and the University of Indonesia. Both universities represent the paradigm of Indonesian literary studies. Faruk [39] offers several paradigms in the study of Indonesian literature, for example humanist literary criticism, structuralist literary criticism, post-structural literary criticism, post -amarxist literary criticism, cultural studies and critical approaches. Faruk offers these paradigms in the context of providing various possible paradigms in Indonesian literature. The paradigm is born from literary studies which at a certain level becomes a paradigm.
\nThe paradigm in Kuhn is a model [40]. Ahimsa-Putra distinguishes paradigms and models. For Ahimsa-Putra [41], the model is part of the paradigm. The model is defined as a parable of the object [41]. Both can be used to formulate contemporary Indonesian literary study models. In the context of combining the concepts of Kuhn and Ahimsa-Putra, Saukko’s concept provides an alternative. Saukko [42] offers four paradigms in cultural studies, namely triangulation, prisms, semiotic material, and dialog. All four applies different metaphors to describe reality. Saukko’s concept can be used to see models in contemporary Indonesian literature.
\nRomantic discourse in the novel
Romantic discourse comes from a different sound. The first is a female voice and the second and third is a male voice. Women’s romantic discourse tends to unite, while men’s romantic discourse tends towards separation and unification. The study of the Indonesian novel Lombok in the third case of the Lombok novel is a model of contemporary Indonesian literary studies. The model can be used to see how ethnic representations in contemporary Indonesian literature with different ethnic cases.
\nStudies in
The meaning of “kidnapping the bride” as dominant discourse of Lombok represents Islamic context. “Kidnapping the bride” practice in Islamic and State perspective positions as a tradition which needs to adapt with Islamic and state law. The meaning of “kidnapping the bride” in
The practice of “kidnapping the bride” is commonly discussed in contemporary Indonesian literature.
This article is part of my dissertation; therefore, I would like to express my great gratitude to the Directorate of Research and Community Service, Directorate General of Strengthening for Research and Development, the Ministry of Research, Technology and Higher Education who has funded this dissertation research.
\nCancer is a generic term, which encompasses a wide group of diseases characterized essentially by an uncontrolled growth and propagation of cells with errors in the division mechanisms known as cell cycle. Cancer constitutes a major public health problem worldwide, since it is the second leading cause of death globally, with 9.6 million deaths estimated in 2018 [1]. Due to the limitations and side effects associated with available cancer treatments nowadays, it is an urgent challenge for medicinal researchers to develop more safe and selective anticancer drugs.
Among the design strategies in drug discovery, special attention has been paid to molecules containing sulfur heterocycles in their structures. Several studies have been carried out with plenty of sulfur heterocycles, including thiophene, thione, benzothiophene, and thiazine, towards different pathologies.
Thiazole ring is present in several anticancer drugs, such as bleomycin, sulfathiazole, thiazofurine, and dasatinib, and its derivatives present excellent pharmacological profiles, making this skeleton an ideal candidate to develop more potent and safer drugs, especially in cancer. Herein, an extensive revision of the most relevant research published in the past 5 years is gathered.
Some aminothiazole as commercial drugs.
Aminothiazole scaffold can be modified by derivatization of the amino group at position 2 of the thiazole ring. Rostom et al. [3] reported a study based on structural modifications including azomethine,
Sun et al. [4] synthesized a series of
Thiazole derivatives as potential antitumor agents.
In other study, a series of tri-substituted aminothiazoles were designed by Lu et al. [5] in order to obtain new antitumoral agents. Compound
A dysregulation of sirtuin 2 (Sirt2) plays an important role in the pathogenesis of cancer, among other diseases. Schiedel et al. [6] designed a series of novel aminothiazole derivatives with the aim of establishing a well-defined SAR model of sirtuin ligands. These thiazole-bearing compounds behaved as selective human sirtuins (hSirt2) inhibitors.
A series of 4-amino-5-cinnamoylthiazoles as chalcone-like structures were synthesized and evaluated as antitumor agents, showing most of them significant cytotoxic activity against MCF-7, HepG2, and SW480 cell lines [8]. The most promising analog, compound
This strategy can be complementary with the inclusion of other structures with recognized biological activities. A series of indole-incorporated thiazolylcoumarins were synthesized and evaluated against a wide range of tumor cell lines [10]. Among the tested compounds, structure
Ayati et al. [11] also reported the synthesis of a series of new coumarin-containing compounds developed from the chalcone-like cinnamoylthiazoles mentioned above. Biological evaluations on the most cytotoxic compound
For the past 5 years, few examples of scaffolds bearing a thiazole ring have been reported with potent efficacy in xenograft models of various types of cancer. Figure 3 encompasses the most relevant examples gathered in the literature that are going to be discussed herein.
Representative scaffolds containing thiazole ring with proven
Attending to their structure, the thiazole analogs can be grouped as follows.
This moiety can be functionalized with several structural modifications. Novel methylsulfonyl benzothiazoles were synthetized and evaluated against HeLA cell line, with compounds
Some thiazole-fused compounds with antitumor activity.
Xie et al. [23] reported a new series of benzothiazole derivatives, with
Benzothiazole derivatives bearing pyrimidine moiety were synthetized and evaluated for anticancer activity against MCF-7, A549, and A375 cancer cell lines, with significant antitumor activity. A further study of the most promising compounds indicated an effect on the expression of proteins that cause abnormal cell proliferation, such as ERK1/2, NF-kB, and survivin [24].
This moiety can also be used in the design of new molecules with a chalcone-like structure, as it has been mentioned before. Imidazole bearing benzothiazoles were synthetized by Sultana et al. [25] and evaluated against several cancer cell lines. Compounds
A series of imidazo[2,1-
Due to the pharmacological properties of the imidazo[2,1-
Kamal et al. [32] also designed a novel series of imidazole merged with thiazole as chalcone-like derivatives and evaluated their cytotoxic activity against MCF-7, A549, HeLA, DU-145, and HT-29 cell lines. Among the compounds tested, structure
A series of thiazolo[3,2-
There is a great variability of transition metals that in combination with different ligands have been reported as antitumoral agents acting through different mechanisms. The literature revealed the considerable interest in the thiazole pharmacophore alone [39], fused to other rings [40], or incorporated into different structures [41] for cancer therapy.
On the other hand, among the most effective and well-studied class of chemotherapeutic agents are the platinum-based drugs, which comprise cisplatin, carboplatin, and oxaliplatin. Given the clinical success of the platinum-based drugs, extensive research efforts have been made to develop alternative metal ions, that is, ruthenium, copper, zinc, and nickel, with antitumor activity.
Besides, Shakir et al. [43] have reported several Cu (II) complexes derived from benzothiazole and thiazole, which showed greater antioxidant and anticancer activities than the corresponding free ligands in various cell lines.
Studies carried out with several Cu (II) complexes with 2,2,6′,2′′-terpyridines revealed that these complexes are able to promote the generation of reactive oxygen species (ROS) in the presence of mild reducing agents. This feature has been exploited to oxidatively break the DNA strands, hence inhibiting the proliferation of tumor cells. In this context, the replacement of two pyridine rings by two thiazole nuclei (compound
Some thiazole-metal complexes with antitumor activity.
In addition, the copper complexes have been recognized as promising drugs for metastatic tumors. For example, copper complexes of pyrrolidine dithiocarbamate (Cu(PDTC)2) possessed potent anticancer activity on cisplatin-resistant neuroblastoma cells. Additionally, two copper thiosemicarbazone complexes showed similar effect on cisplatin-resistant neuroblastoma cells and prostate cancer. Xie et al. [46] reported the synthesis and antitumoral activity of two copper complexes of (4
It is notably that a number of copper (II) complexes have been shown to present antitumor activity, through inhibition of human topoisomerase IIα. Recently, Sandhaus et al. [47] have identified a new complex (compound
Rubino and co-workers [50] have reported two new mono-Pt(II) and binuclear chloro-bridged Pd(II) complexes with 2,2′-dithiobis(benzothiazole) as ligand. Only platinum derivative has emerged as an effective inductor of apoptotic death on HepG2 and MCF-7 cells and caused cell cycle arrest at G0/G1 phase while palladium was inactive. On the other hand, the inclusion of 2-(4-substituted)benzothiazoles (compound
In addition, thiazolidinone-derived complexes, specifically with (
Cobalt (II) complexes are one of the most studied, and they have been reported as cytotoxic agents
In recent years, lanthanum (III) complexes are emerging as promising agents due to their more physiological activities and lower toxicities after coordination with ligands. The main mechanism of action associated is the interaction with DNA by intercalation mode. Likewise, these compounds are useful as clinical biomarkers for early diagnosis of the presence of prostate cancer. One of the most relevant lanthanum (III) derivative is 2,3-dihydro-1
Another relevant option is the gold(I) compounds that can act as prodrugs. Thus, 2-mercapto thiazoline as ligand by reaction with K[Au(CN)2] resulted in the nitrogen-coordinated complex [NCAu(N-mtz)]. On the other hand, reaction with [(Ph3P)AuCl] yielded the sulfur-coordinated complex [(Ph3P)Au(S-mtz)]. Both of them inhibited the growth of tumorigenic cell lines such as the human ovarian carcinoma (A2780), human colon carcinoma (HCT116), and human breast adenocarcinoma (MCF7) [58].
Finally, another strategy to design new complexes as antitumoral agents is the combination of anti-inflammatory derivatives with metals. In this approach, the 1,2-benzothiazines nuclei, which are present in meloxicam and piroxicam, were complexed with ruthenium and osmium to obtain new derivatives with potent activity against cancer cell lines [59].
Thiazoles and thiazolines are quite common motifs present in peptides isolated from natural sources, many of them known for having biological activity, typically antibacterial. These peptides are biosynthesized from nonribosomal peptide synthase (NRPS) or ribosomally produced and post-translationally modified. Both processes involve cyclodehydrations of cysteine residues to yield thiazolines and subsequent dehydrogenations to give thiazoles [60]. In this context, marine organism (cyanobacteria, fungi, sponges, tunicates, ascidians, etc.) provide an endless source of new structures with biological potential, cancer included [61]. Many isolated thiazole-containing peptides from nature have anticancer properties
Cyanobacteria-derived bisebromoamide was isolated and tested against HeLa S3 cells, showing a very low IC50 [62]. It was also shown to induce apoptosis through ERK and mTOR inhibition in renal carcinoma cell lines [63]. A modification of central thiazoline of bisebromoamide by a thiazole and alanine scanning [64] provided new analogs, getting insights in the structural dependence of the cytotoxicity. Four analogs showed nanomolar cytotoxicity activity against human colon tumor cell line HCT116.
P-glycoprotein (P-gp, multidrug resistance protein 1) is overexpressed in patients suffering from chemotherapy resistance. In this sense, cyclic and acyclic (
Thiazole/thiazoline containing peptides and peptidomimetics with anticancer activity.
Polyamides based on 2 and 3 repeating units of 2-aminothiazole-4-carboxylic acid were synthetized [69] and proved to bind selectively to c-
Thiazole scaffold is also present in short peptides known for inhibiting tubulin polymerization. Dolastatin 10 was firstly isolated from
Another thiazole-containing peptides targeting to tubulin polymerization are the tubulysins (Figure 6), isolated first from myxobacteria. Great number of modifications have been attempted to date, and numerous SAR studies have shed light into tubulysin mode of action (for a review, see ref. [72]).
In this context, a pretubulysin (tubulysin biosynthetic precursors) lacking of
One objective for researchers working with tubulysins is the improvement of their therapeutic efficacy by the targeted cancer therapy as antibody-drug conjugation (ADC) or small molecule drug conjugates (SMDC), acting the tubulysins as payloads. This represents a very powerful tool, which is already being applied to all class of tubulin inhibitors [78]. Tubulysin warheads are therefore being used in ADC; one of them (AZ13599185) is in phase I clinical trials targeting HER2 receptors, involved in breast cancer development [79]. Following this trend, the modifications of tubulysins for an easier linking to conjugates is a new goal. New derivatizations at
Cyclic depsipeptide largazole was discovered from cyanobacteria
Largazole inhibition of HDAC is actually attained by largazole thiol derived from thioester hydrolysis. The thiol forms a thiolate-Zn2+ complex [88], a critical binding for the activity, since substitution by other poorer Zn-binding groups correlated to less HDAC inhibition and lower cytotoxicity [89]. The octanoyl side chain on the thioester allows good cell permeability. Thus, modifications can be made for a better membrane permeability and thiol liberation inside the cell. In this sense, controlled release of largazole thiol from an isobutylene-caged largazole thiol derivative, which possesses a high permeability, has been achieved by UV light photoactivation of a thiol-ene triggering reaction [90].
Cyclic thiazole- and oxazoline-containing octapeptides and patellamides, isolated from marine tunicates, have also been an object of modification. It has been shown that changes in the position of thiazoles and oxazolines in ascidiacyclamide can influence their cytotoxic activity, obtaining inactive derivatives and 10 times more active compounds depending on the conformations attained [91].
Apratoxin- and thiazoline-containing depsipeptides are known potent cytotoxins isolated from marine cyanobacteria. Apratoxins are known for being potent anticancer agents and co-translational translocation inhibitors. Different derivatives have been synthetized, involving thiazoline stereogenic configuration change at
Incorporation of thiazole ring into different molecules have demonstrated to be a novel and promising approach to design more potent and safer antitumor drugs. The results of this chapter might help to enlighten other researchers to better design bioactive molecules. This thiazole ring can be incorporated as part of mono- or fused-cycles, metal complexes, or as a part of peptides. In many of these cases, the deletion of thiazole ring entails the loss of the bioactivity pointing out the importance of this ring for the anticancer activity. Thus, we consider this class of compounds and excellent starting point to achieve future drug candidates to treat cancer.
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\n\nWe have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
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There are 91 (33) TCs and 113 (50) cases with CE identified in the WNP (ATL). Three CE structural change types are classified as follows: a CE with the inner eyewall dissipated in an eyewall replacement cycle (ERC, 51 and 56% in the WNP and ATL), a CE with the outer eyewall dissipated first and the no eyewall replacement cycle (NRC, 27 and 29% in the WNP and ATL), and a CE structure that is maintained for an extended period (CEM, 23 and 15% in the WNP and ATL). The moat size and outer eyewall width in the WNP (ATL) basin are approximately 20–50% (15–25%) larger in the CEM cases than that in the ERC and NRC cases. Our analysis suggests that the ERC cases are more likely dominated by the internal dynamics, whereas the NRC cases are heavily influenced by the environment condition, and both the internal and environmental conditions are important in the CEM cases. A good correlation of the annual CE TC number and the Oceanic Niño index is found (0.77) in WNP basin, with most of the CE TCs occurring in the warm episodes. In contrast, the El Niño/Southern Oscillation (ENSO) may not influence on the CE formation in the ATL basin. After the CE formation, however, the unfavorable environment that is created by ENSO may reduce the TC intensity quickly during warm episode. The variabilities of structural changes in the WNP basin are larger than that in the ATL basin.",book:{id:"5180",slug:"recent-developments-in-tropical-cyclone-dynamics-prediction-and-detection",title:"Tropical Cyclone Dynamics, Prediction, and Detection",fullTitle:"Recent Developments in Tropical Cyclone Dynamics, Prediction, and Detection"},signatures:"Yi-Ting Yang, Hung-Chi Kuo, Eric A. Hendricks and Melinda S. 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An analysis of regime shift index reveals that the worldwide TC activity experienced four significant abrupt changes during 1960–2014, including (i) an abrupt increase/decrease in the eastern North Pacific (ENP)/western North Pacific (WNP) in the early 1970s, (ii) an abrupt increase in the ENP and WNP in the early 1980s, (iii) an abrupt increase in the North Atlantic and ENP in the middle 1990s, and (iv) an abrupt decrease in the WNP and western South Pacific in the late 1990s. Three of them are identified concurrent with a significant CRS. The possible influence of a CRS on the abrupt change of TC activity in various genesis regions is addressed. We demonstrate that a CRS induced time mean state shift results in a rapid change in the large-scale dynamic and thermodynamic conditions, which substantially contributes to the abrupt change of TC activity in various genesis regions. 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Maximum temperatures, however, have already registered higher values in different regions of the world, increasing the number, duration and intensity of heat waves. With the increase of maximum temperatures and the increase of significance of heat wave events, reports of mortality episodes due to heat effects have been increasing. According to the information from the Centre for Research on Epidemiology of Disasters (CRED), 5 of the 20 deadliest disasters between 1996 and 2015 were heat wave events. This chapter analyzes heat wave events, the criteria for determining dangerous temperature thresholds, as well as trends already observed, and those expected due to climate change. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. 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