Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\\n\\n
Seeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\n
Over these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\n
We are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\n
Thank you all for being part of the journey. 5,000 times thank you!
\\n\\n
Now with 5,000 titles available Open Access, which one will you read next?
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
\n\n
"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
\n\n\n\n
Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\n
Seeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\n
Over these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\n
We are excited about the present, and we look forward to sharing many more successes in the future.
\n\n
Thank you all for being part of the journey. 5,000 times thank you!
\n\n
Now with 5,000 titles available Open Access, which one will you read next?
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"1001",leadTitle:null,fullTitle:"Tumor Microenvironment and Myelomonocytic Cells",title:"Tumor Microenvironment and Myelomonocytic Cells",subtitle:null,reviewType:"peer-reviewed",abstract:"Tumor microenvironment represents an extremely dynamic niche shaped by the interplay of different cell types (e.g. tumor cells, stromal cells), their soluble products (e.g.cytokines, chemokines and growth factors) and varied physico-chemical conditions (e.g low oxygen concentration or hypoxia). Recent studies have identified myelomonocytic cells as key players in regulating the tumor microenvironment and hence, tumor progression in a variety of cancers. In view of these findings, the present book attemps to provide a comprehensive account of the diversity of tumor microenvironment across different cancers and how myelomonocytic cells have taken the center-stage in regulating this niche to direct cancer progression. A better understanding of the myelomonocytic cells and the mechanisms by which they regulate cancer progression will open new vistas in cancer therapeutics.",isbn:null,printIsbn:"978-953-51-0439-1",pdfIsbn:"978-953-51-6946-8",doi:"10.5772/1507",price:139,priceEur:155,priceUsd:179,slug:"tumor-microenvironment-and-myelomonocytic-cells",numberOfPages:312,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a2392066cd104cd48f3b296bf72b97a6",bookSignature:"Subhra K. 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Dr. Biswas completed his Ph.D in Biotechnology at Banaras Hindu University, India, following which he did his post-doctoral study at the Istituto di Ricerche Farmacologiche \\Mario Negri\\ in Milan, Italy. He is a principal investigator at the Singapore Immunology Network (SIgN), Agency for Science, Technology & Research (A*STAR), Singapore. Dr. Biswas’s major contribution in this field was the first molecular characterization of tumor associated macrophages. Dr. Biswas is a member of the American Association of Immunologists and European Macrophage and Dendritic Cell Society and an editorial board member of Scientific Reports, Cancer Microenvironment and Frontiers in Tumor Immunity.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"A*STAR-NUS Clinical Imaging Research Centre",institutionURL:null,country:{name:"Singapore"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1083",title:"Medical Oncology",slug:"medical-oncology"}],chapters:[{id:"34378",title:"Cell Lineage Commitment and Tumor Microenvironment as Determinants for Tumor-Associated Myelomonocytic Cells Plasticity",doi:"10.5772/34377",slug:"cell-lineage-commitment-and-tumor-microenvironment-as-determinants-for-tumor-associated-myelomonocyt",totalDownloads:2022,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Raffaella Bonecchi1, Benedetta Savino1,\r\nMatthieu Pesant1 and Massimo Locati1",downloadPdfUrl:"/chapter/pdf-download/34378",previewPdfUrl:"/chapter/pdf-preview/34378",authors:[{id:"99884",title:"Prof.",name:"Massmo",surname:"Locati",slug:"massmo-locati",fullName:"Massmo Locati"}],corrections:null},{id:"34379",title:"Functions of Diverse Myeloid Cells in the Tumor Micro-Environment",doi:"10.5772/35123",slug:"functions-of-diverse-myeloid-cells-in-the-tumor-micro-environment",totalDownloads:2439,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Paola Allavena and Antonio Sica",downloadPdfUrl:"/chapter/pdf-download/34379",previewPdfUrl:"/chapter/pdf-preview/34379",authors:[{id:"103051",title:"Dr.",name:"Paola",surname:"Allavena",slug:"paola-allavena",fullName:"Paola Allavena"},{id:"104290",title:"Dr.",name:"Antonio",surname:"Sica",slug:"antonio-sica",fullName:"Antonio Sica"}],corrections:null},{id:"34380",title:"Monocyte Subsets and Their Role in Tumor Progression",doi:"10.5772/32615",slug:"monocyte-subsets-and-their-role-in-tumor-progression",totalDownloads:3765,totalCrossrefCites:3,totalDimensionsCites:6,hasAltmetrics:0,abstract:null,signatures:"Andrea Doseff and Arti Parihar",downloadPdfUrl:"/chapter/pdf-download/34380",previewPdfUrl:"/chapter/pdf-preview/34380",authors:[{id:"92127",title:"Dr",name:"Andrea",surname:"Doseff",slug:"andrea-doseff",fullName:"Andrea Doseff"},{id:"127683",title:"Dr.",name:"Arti",surname:"Parihar",slug:"arti-parihar",fullName:"Arti Parihar"}],corrections:null},{id:"34381",title:"Myeloid Derived Suppressor Cells: Subsets, Expansion, and Role in Cancer Progression",doi:"10.5772/36409",slug:"myeloid-derived-suppressor-cells-subsets-expansion-and-role-in-cancer-progression",totalDownloads:8062,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Jean-Pierre Abastado and Liang Zhi",downloadPdfUrl:"/chapter/pdf-download/34381",previewPdfUrl:"/chapter/pdf-preview/34381",authors:[{id:"34324",title:"Dr.",name:"Jean-Pierre",surname:"Abastado",slug:"jean-pierre-abastado",fullName:"Jean-Pierre Abastado"},{id:"102924",title:"Dr.",name:"Liang",surname:"Zhi",slug:"liang-zhi",fullName:"Liang Zhi"}],corrections:null},{id:"34382",title:"The Role of Hypoxia in Re-educating Macrophages in the Tumour Environment",doi:"10.5772/48976",slug:"the-role-of-hypoxia-in-re-educating-macrophages-in-the-tumour-environment",totalDownloads:2648,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Reuben J. 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\r\n\tTelehealth is a kind of health service via electronic information and technologies which allows clinicians to care for long-distance patients. Telehealth includes clinical and non-clinical services, such as monitoring, diagnosis, treatment, and even preventative and promotive care delivery. Telemedicine is a more common term that describes remote clinical services.
\r\n
\r\n\tFrom the end of 2019, the major impact caused by COVID-19 has made Telemedicine the mainstream in the coming years. This means the clinicians have to use Tele-consultation, Tele-monitoring, Tele-education, Tele-prescription, Tele-surgery, and other remote methods and technologies for disease evaluation and treatment. However, the complex nature of Telemedicine also lets us re-check whether the existing Telemedicine is sufficient to meet the higher-level medical needs in theory and practice.
\r\n
\r\n\tPatient-Centric is when the needs for information and interaction originate from the patients. Personalized data generated by the various monitoring technologies are jointly managed by patients and medical staff. Medical staff will supervise artificial intelligence (AI) algorithms to understand the patient’s specific condition and provide the best decision-making and treatment. Thus the dream of precision medicine will come true in the future.
\r\n
\r\n\tBased on these concepts, the book incorporates updated developments as well as future perspectives in the ever-expanding field of Telehealth / Telemedicine. Besides, this book will be also a great reference for medical staff(physicians, surgeons, family doctors, ENT doctors, audiologists, psychologists, registered nurses, technologists), specialists in sleep medicine, social workers, public health practitioners, researchers in basic medicine, experts in science, students, and even patients themselves.
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\n
1. Introduction
\n
Henri Poincaré, (1892–1908), [1], was first to acknowledge the possible existence of chaos in nonlinear systems while studying a 3-body problem comprising Sun, Moon and Earth. He noticed the dynamics of the system turned to be sensitive towards initial conditions, which was later termed as chaos. His results based on theoretical analysis and he could not demonstrate it because computers were not available at that time. Lorenz, a weather scientist, demonstrated existence of chaos by using a computer in 1963, [2], and in this way supported chaos theory of Poincaré. Thus, Lorenz provided the foundation of chaos theory and inspired a fundamental reappraisal of systems of nonlinearity in many disciplines of science, engineering, biological and medical sciences, atmospheric science, economics, social sciences and where not? In our everyday life, chaos happened frequently in various form like cyclone, tsunami, tornado, epidemics/pandemics etc. Spread of any uncontrollable form of disease in medical science is nothing but a chaotic and contagious nature of disease. Systematic studies in various areas resulting in numerous articles on chaos and nonlinear dynamics appeared in many well-reputed scientific journals, [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19].
\n
Most biological systems exhibit enormous diversity and structurally multicomponent resulting in ecological imbalance and disorder/disharmony in environment. Inspired by articles of Lotka, Volterra, and Allee, numerous articles appeared with diversity in assumptions depending of species and their living environmental conditions in predator-prey models, [20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44].
\n
Real systems are mostly nonlinear and many of them are with multicomponent structure. Their individual elements possess individual properties. Such systems are termed as the complex system.
\n
During evolution, a complex system exhibits chaos in some parameter space but also some other phenomena called complexity. This complexity is due to the interaction among multiple agents within the system displayed in the form of coexistence of multiple attractors, bistability, intermittency, cascading effects, exhibit of hysteresis properties etc. Thus, complexity can viewed as its systematic nonlinear properties and it is due to the interaction among multiple agents within the system. Foundation work and elaborate descriptions on complexity can viewed from some pioneer articles on complexity in nonlinear dynamics presented in [45, 46, 47, 48, 49, 50, 51]. Study of complexity means to know the results that emerging from a collection of interacting parts.
\n
A dynamical system be chaotic then it must be (i) sensitive to initial conditions, (ii) topologically mixing and (iii) its periodic orbits must be dense. In chaotic systems, there exists a strange attractor, a chaotic set, which has fractal structure. Complex systems are also sensitive to their initial conditions and two complex systems that are initially very close together in terms of their various elements and dimensions can end up in distinctly different places. Wide discussions on complex system may found in some pioneer literatures, [14, 18, 45, 46, 48, 50, 51].
\n
Chaos measured by Lyapunov exponents, (also called Lyapunov characteristic components or LCEs); LCE > 0 indicates existence of chaos and LCE < 0 indicates regularity, [52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62]. A complex system can better understood by measuring (i) chaos, (ii) Topological entropies and (iii) correlation dimension. Topological entropy, a non-negative number, provides a perfect way to measure complexity of a system. More topological entropy in any system signifies more complexity in it. Actually, it measures the evolution of distinguishable orbits over time, thereby providing an idea of how complex the orbit structure of a system is, [48, 49, 50, 61, 62, 63, 64, 65, 66, 67, 68, 69]. A system may be chaotic with zero topological entropy. In addition, a significant increase in topological entropy does not justify that it is chaotic. The book by Nagashima and Baba, [62], gives a very clear definition of topological entropy. The correlation dimension provides the dimensionality of the chaotic attractor. Correlation dimensions are non-integers and this is one reasons besides self-similarity that chaotic sets have fractal structure, [60, 68, 69, 70, 71, 72, 73].
\n
It emerges from a good number of recent researches that chaos appearing in dynamical system be controlled and suggested number techniques to control chaos, [74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88]. These techniques have some limitations depending on the models and nature of nonlinearity.
\n
Objective of this article is to investigate the emergence of chaos and complexity in nonlinear dynamical systems through examples of nonlinear models. Numerical simulations carried out for bifurcation analysis, plotting of LCEs and topological entropies for different systems. Numerical calculations extended to obtain correlation dimensions for certain chaotic attractors emerging in different systems. The study further extended to explain different types of chaos controlling technique. Studies confined to one, two and three-dimensional systems only.
\n
\n
\n
2. Dynamic models with chaos and complexity
\n
\n
2.1 One dimensional discrete models
\n
\n
2.1.1 Dynamics of laser map
\n
A highly simplified type discrete nonlinear model for laser system, arising from Laser Physics, described in articles, [12, 50, 89, 90, 91]. The model describes evolution of certain Fabry-Perot cavity containing a saturable absorber and driven by an external laser represented by
Here Q is the normalized input field and A is a parameter depends on the specifics of the parameters and A > 0. The fixed points of the map are the real root of equation
This equation has either three real roots or one real and a pair of complex conjugate roots depending on parameter space \n\n\nA\nQ\n\n\n. Stability occur in the form of stability and bistability, [89].
\n
\nFixed Points and Bifurcations:
\n
For \n\nQ\n\n fixed, \n\nQ\n=\n2.76\n\n, and \n\nA\n<\n4.3793\n\n, only one stable steady state solution exits and stable two cycle starts when \n\nA\n\n exceeds this value. Thus, approximately, \n\nA\n=\n4.3793\n\n, is the bifurcation point. At value \n\nA\n=\n4.3\n\n, the stable steady state solution is x* = 0.720533.
\n
Keeping \n\nQ\n=\n2.76\n\n and varying parameter \n\nA\n\n, bifurcation diagrams are drawn, \nFigure 1\n, for four different ranges of values of \n\nA\n\n. Similarly, keeping \n\nA\n\n fixed, \n\nA\n=\n5.4\n\n and varying \n\nQ\n\n in four different ranges, bifurcation diagrams are drawn, \nFigure 2\n. One observe clearly the appearance of periodic windows within chaotic region of bifurcations as an indication of intermittency and other complex phenomena. Periodic windows become gradually shorter and appearance become more frequent while moving forward in parameter space.
\n
Figure 1.
Bifurcation diagrams of map (1) for four cases: when Q = 2.76 and parameter A varies.
\n
Figure 2.
Bifurcation diagrams of map (1) for four cases: when A = 5.4 and parameter Q varies.
\n
Both time series plots shown in \nFigure 3\n are for chaotic evolution of system (1) and correspond to parameters (a) \n\n\nA\nQ\n\n\n = (5.3, 2.76), due to which an unstable fixed point obtained as \n\n\nx\n*\n\n=\n0.58531\n\n, and parameters (b) ) \n\n\nA\nQ\n\n\n = (5.4, 2.9), due to which an unstable fixed point obtained as \n\n\nx\n*\n\n=\n0.572218\n\n. For both cases, initial point taken is \n\n\nx\n0\n\n=\n0.5\n\n which lies nearby these points and so, also, unstable.
\n
Figure 3.
Chaotic time series plots with initial value x0 = 0.5: (a) A = 5.3, Q = 2.76 and (b) A = 5.4, Q = 2.9.
\n
\nCalculations of Lyapunov Exponents, (LCEs):\n
\n
Lyapunov exponents, LCEs, for map (1), calculated for four cases, \nFigure 4\n, positive LCEs appearing above zero line clearly indicate chaotic motion and those below this line indicate regular motion.
\n
Figure 4.
Plots of LCEs: (a) for the upper row Q = 2.76, 4.0 ≤ A ≤ 5.5 and 5.0 ≤ A ≤ 7.0; (b) for the lower row A = 5.4, 0.5 ≤ Q ≤ 3.5 and 1.4 ≤ Q ≤ 1.8.
\n
\nTopological Entropies:\n
\n
Numerical calculations further proceeded to calculate topological entropies for system (1) and shown in \nFigure 5\n; where figures of upper row obtained by varying parameter A while keeping parameter Q = 2.76 and those of lower row obtained by varying parameter Q while keeping parameter A = 5.4.
\n
Figure 5.
Topological entropy plots: (a) for upper row Q = 2.76 and 4.0 ≤ A ≤ 5.5 & 4.7 ≤ A ≤ 5.3; (b) for lower row A = 5.4 and 0.4 ≤ Q ≤ 2.5 & 1.4 ≤ Q ≤ 1.9.
\n
\nCorrelation Dimension:\n
\n
Extending further the numerical study, correlation dimensions of system (1) calculated for a chaotic attractor by using Mathematica codes, [73].
\n
Consider an orbit \n\nO\n\n\nx\n1\n\n\n\n = \n\n\n\nx\n1\n\n\nx\n2\n\n\nx\n3\n\n\n\nx\n4\n\n…\n…\n\n\n\n, of a map \n\nf\n:\nU\n→\nU\n\n, where \n\nU\n\ns an open bounded set in \n\n\nR\nn\n\n\n. To compute correlation dimension of \n\nO\n\n\nx\n1\n\n\n\n, for a given positive real number \n\nr\n\n, we form the correlation integral,
is the unit-step function, (Heaviside function). The summation indicates number of pairs of vectors closer to \n\nr\n\n when\n\n1\n≤\ni\n\n, \n\nj\n≤\nn\n\n and \n\ni\n≠\nj\n\n. \n\nC\n\nr\n\n\n measures the density of pair of distinct vectors \n\n\nx\ni\n\n\n and \n\n\nx\nj\n\n\n that are closer to \n\nr\n\n.
\n
The correlation dimension \n\n\nD\nc\n\n\n of \n\nO\n\n\nx\n1\n\n\n\n is then defined as
To obtain \n\n\nD\nc\n\n\n, \n\nlog\nC\n\nr\n\n\n is plotted against log \n\nr\n\n, \nFigure 6\n, and then we find a straight line fitted to this curve. The intercept of this straight line on y-axis provides the value of the correlation dimension DC. Correlation dimensions of time series attractors, \nFigure 3\n, obtained as:\n
For first attractor, Q = 2.76, A = 5.3, a plot of the correlation integral curve is shown in \nFigure 6\n. Then, the linear fit of the correlation data used in this figure obtained as
\n\ny\n=\n0.95661\nx\n+\n0.687605\n\n
\n
The y-intercept of this straight line is \n\n0.687605\n\n. Therefore the correlation dimension of the attractor in this case is \n\n\nD\nC\n\n=\n0.69\n\n\n.
In a similar way, correlation dimension for second attractor of \nFigure 3\n, A = 5.4 and Q = 2.9, as \n\n\nD\nc\n\n=\n0.56\n\n. Plots of correlation dimensions against parameters A, Q shown in \nFigure 7\n.
\n\n
Figure 6.
Plot of correlation integral curve for A = 5.3, Q = 2.76 and x0 = 0.5.
\n
Figure 7.
Plots of correlation dimensions: (a) with Q = 2.76 and varying A, (b) with A = 5.4 and varying Q.
\n
\n
\n
2.1.2 Dynamics of biological red cells model
\n
The population of red blood cells in a healthy human being oscillates within a certain tolerance interval in normal circumstances. But, sometimes, in presence of a disease such as anemia, this behavior fluctuate dramatically. A discrete model of blood cell populations, Martelli, ([73], p: 35), presented here.
\n
Let \n\n\nx\nn\n\n,\n\nx\n\nn\n+\n1\n\n\n\n representing quantities of cells per unit volume (in millions) at time \n\nn\n\n\nand \n\nn\n+\n1\n\n, respectively and \n\n\np\nn\n\n,\n\nd\nn\n\n\n are, respectively, the number of cells produced and destroyed during the nth generation then
The case a \n\n=\n1\n\n , means that during the time interval under consideration all cells that were alive at time \n\nn\n\n are destroyed. In such a case, above models simply comes as
For \n\na\n=\n0.8\n\n, \n\nb\n=\n10\n\n , \n\nr\n=\n6\n\n and \n\ns\n=\n2.5\n\n , three fixed points \n\n\n\nx\n∗\n\n0\n\n=\n0\n,\n\n\nx\n∗\n\n1\n\n=\n0.989813\n,\n\n\n\n\n\nx\n∗\n\n2\n\n=\n3.53665\n\n obtained for system (6) of which only \n\n\nx\n0\n∗\n\n=\n0\n\n\n is stable and other two are unstable. Chaotic motion observed for values of parameter \n\na\n=\n0.8\n,\nb\n=\n10\n,\nr\n=\n6\n,\ns\n=\n2.5\n\n, as shown in the time series plot, \nFigure 8\n, with initial condition \n\n\nx\n0\n\n=\n1.5\n\n.
\n
Figure 8.
Chaotic time series plot of map (6) for \n\na\n\n = 0.8, \n\nb\n\n = 10, \n\nr\n\n = 6, \n\ns\n\n\n= 2.5 and \n\n\nx\n0\n\n=\n1.5\n\n.
\n
Interesting bifurcations observed for this map: For \n\nb\n\n = 1.1 × 106, \n\nr\n\n = 8, two bifurcation diagrams are drawn; (a) in one for \n\ns\n\n =16 and \n\n0\n≤\na\n≤\n1\n\n, and (b) in another for \n\na\n=\n0.8\n\n and \n\n3.5\n≤\ns\n≤\n16.0\n\n and shown in \nFigure 9\n. In former case one finds initially period doubling bifurcation followed by loops before emergence of chaos. In later case, one finds some typical type of bifurcation showing chaos adding, folding and the bistability like phenomena. A magnification of right figure, \nFigure 10\n, for smaller range, \n\n4.5\n≤\ns\n≤\n8.5\n\n, justifying chaos adding behavior.
\n
Figure 9.
Bifurcation plots of Blood Cell model for \n\n=\n8\n\n , \n\nb\n\n = 1.1 × 106 then for (a) \n\ns\n\n= 16 and 0 ≤ \n\na\n\n ≤ 1 and for (b) \n\na\n\n = 0.1 and \n\n3.5\n≤\ns\n≤\n16\n.\n\n\n
\n
Figure 10.
Bifurcation of Blood Cell model when \n\n3.0\n≤\ns\n≤\n7.5\n\n and \n\na\n=\n0.8\n,\n\n\n\nr\n=\n8\n\n, \n\nb\n\n = 1.1 × 106.
\n
Regular and chaotic motion experienced through bifurcation diagrams, \nFigures 9\n and \n10\n, again confirmed by plots of Lyapunov exponents, \nFigure 11\n. This system, bears enough complexity and, as its measure, plot of topological entropies, \nFigure 12\n, obtained for values \n\nr\n=\n6\n\n, \n\ns\n=\n16\n\n and \n\nb\n\n = 1.1 × 106 and \n\n0\n≤\na\n≤\n1\n\n. Fluctuations in increase of topological entropies appear, approximately, in the region \n\n0.25\n≤\na\n≤\n0.95\n\n indicate existence of complexity.
\n
Figure 11.
LCE Plots for \n\n=\n6\n\n , \n\ns\n=\n16\n\n and \n\nb\n\n = 1.1 × 106 , negative and positive values of LCEs, respectively, below and above the zero line show the regular and chaotic zones of parameter space.
\n
Figure 12.
Topological entropy plot for \n\nr\n=\n6\n,\ns\n=\n16\n\n and \n\nb\n\n = 1.1 × 106 and \n\n0\n≤\na\n≤\n1\n\n.
\n
The correlation dimension of its chaotic attractor for values \n\na\n=\n0.78\n,\n\n when \n\nr\n=\n6\n\n, \n\ns\n=\n16\n\n and \n\nb\n\n = 1.1 × 106 is obtained as \n\n\nD\nc\n\n≅\n0.253\n\n.
\n
\n
\n
\n
2.2 Two-dimensional models
\n
\n
2.2.1 Two-Gene Andrecut-Kauffman System
\n
Chaos and complexity study of a discrete two-dimensional map for two-gene system, proposed by Andrecut and Kaufmann, investigated recently, [35, 71, 92]. The map used to investigate the dynamics of two-gene system for chemical reactions corresponding to gene expression and regulation. The discrete dynamic variables xn and yn describe the evolutions of the concentration levels of transcription factor proteins. The map represented by following pair of difference equations:
With parameter values \n\na\n=\n25\n\n, \n\nb\n=\n0.1\n\n, \n\nc\n=\nd\n=\n0.18\n\n and \n\nt\n=\n3\n\n, one obtains four different fixed points with coordinates (2.30409, 2.30409), (−2.52688, 2.44162), (2.44162, −2.52866), (−2.39464, −2.39464 ) and all are unstable.
\n
For \n\nc\n≠\nd\n\n and when \n\na\n=\n25\n,\nb\n=\n0.1\n,\nc\n=\n0.18\n,\nd\n=\n0.42\n\n, and \n\nt\n=\n3\n\n, again, four unstable fixed points exists as (2.2832, 2.5413), (−2.5458, 2.6566), (2.4613, −2.7288), (−2.3744, −2.61705).Therefore, for all these the cases, orbit with initial point taken nearby any of the fixed points be unstable and may be chaotic also.
\n
We intend to investigate certain dynamic behavior of system (8) for cases when \n\nc\n=\nd\n\n and when \n\nc\n≠\nd\n\n of evolutions showing irregularities due to presence of chaos and complexity.
\n
\nNumerical Simulations:\n
\n
Drawing bifurcation diagrams and calculating Lyapunov exponents, topological entropy and correlation dimensions of the system for different cases have investigated performing numerical simulations. For values of the control parameters following ranges proposed:\n\n\na\n∈\n\n0\n50\n\n\n , \n\nc\n∈\n\n\n−\n0.4,0.4\n\n\n\n, \n\nb\n=\n0.1\n\n, \n\n\nd\n=\n0.5\n\n,\n\n\nt\n=\n3\n,\n4\n,\n5\n\n.
\n
Case 1: Taking \n\nc\n=\nd\n\n, bifurcation diagrams are drawn along the directions \n\nx\n\n and \n\ny\n\n, by varying \n\nc\n\n for cases \n\nt\n\n = 3, 4, 5 and certain fixed values of other parameters as shown in \nFigure 13\n. Then, plots of attractors have been obtained for parameters \n\na\n=\n25\n,\nb\n=\n0.1\n,\nt\n=\n3\n\n and (i) for regular case \n\nc\n=\nd\n=\n0.32\n\n and (ii) for chaotic case \n\nc\n=\nd\n=\n0.18\n\n and shown in \nFigure 14\n. In each case when \n\nt\n\n = 3, 4, 5, bifurcations show period doubling leading to chaos and then to regularity. Also, bistability and folding nature of phenomena are appearing here.
\n
Figure 13.
Three cases of bifurcation scenarios of map (8) for parameters \n\nc\n=\nd\n\n: (a) \n\nt\n\n= 3, \n\na\n=\n25\n,\nb\n=\n0.1\n\n and 0 ≤ \n\nc\n\n ≤ 0.5; (b) \n\nt\n\n = 4, \n\na\n=\n35\n,\nb\n=\n0.1\n\n and 0 ≤ \n\nc\n\n ≤ 0.65; (c) \n\nt\n\n = 5, \n\na\n=\n25\n,\nb\n=\n0.1\n\n and 0 ≤ \n\nc\n\n ≤ 0.5.
\n
Figure 14.
Figures (a), (b), (c) correspond to time series, phase plane attractors and Lyapunov exponents; upper row is for regular case and the lower row is for chaotic case of map (8). Parameters values are taken as \n\na\n=\n25\n,\nb\n=\n0.1\n,\nt\n=\n3\n\n and (i) for regular case \n\nc\n=\nd\n=\n0.32\n\n and (ii) for chaotic case \n\nc\n=\nd\n=\n0.18\n\n.
\n
\nLyapunov Exponents & Topological Entropies:
\n
For chaotic evolution, when \n\na\n=\n25\n,\nb\n=\n0.1\n,\nt\n=\n3\n,\nc\n=\nd\n=\n0.18\n\n, Lyapunov exponents are obtained shown in \nFigure 15\n. Numerical investigations further proceeded for calculation of topological entropies. In \nFigure 16\n, plots of topological entropies are presented for \n\nt\n\n = 3, 4, 5 and for different ranges of parameter \n\nc\n.\n\n Analysis of these plots, gives an impression that for the case \n\nt\n\n = 3, system shows enough complexity in the range 0.05 ≤ \n\nc\n\n ≤ 0.23. For the case \n\nt\n\n = 4, the system shows high complexity in the range 0 ≤ \n\nc\n\n ≤ 0.22 and in case \n\nt\n\n = 5, high complexity appears in 0 ≤ \n\nc\n\n ≤ 0.44.
\n
Figure 15.
Plots of Lyapunov exponents for chaotic evolution of map (8). Parameters are \n\na\n=\n25\n,\nb\n=\n0.1\n,\nt\n=\n3\n,\nc\n=\nd\n=\n0.18\n\n\nand when evolving from initial point (2.1, 2.1).
\n
Figure 16.
Plots of topological entropy for map (8) when parameter \n\nc\n=\nd\n\n. From left: (i) \n\nt\n\n = 3, \n\na\n=\n25\n,\nb\n=\n0.1\n\n and 0 ≤ \n\nc\n\n ≤ 0.5; (ii) \n\nt\n\n = 4, \n\na\n=\n35\n,\nb\n=\n0.1\n\n and 0 ≤ \n\nc\n\n ≤ 0.65; (iii) \n\nt\n\n = 5, \n\na\n=\n25\n,\nb\n=\n0.1\n\n and 0 ≤ \n\nc\n\n ≤ 0.8.
\n
Case II: When c and d are different, bifurcation diagrams, \nFigure 17\n, shows clear picture of complex nature of the system.
\n
Figure 17.
Bifurcation plots when \n\nc\n≠\nd\n\n for different ranges of parameter \n\nc\n\n. Cases (a), (b), (c), corresponds to \n\nt\n\n = 3, \n\nt\n\n = 4, \n\nt\n\n = 5. Parameters are \n\na\n=\n25\n,\nb\n=\n0.1\n\n and \n\nd\n=\n0.20\n\n for plots (a) & (c) and \n\nd\n\n = 0.30 for plot (b).
\n
In \nFigure 18\n, plots of Lyapunov exponents, (LCE’s), for chaotic evolution for different cases discussed above are shown in the upper row and plots of topological entropies are shown in the lower row for these cases. For all the plots, parameters \n\na\n\n = 25 and \n\nb\n\n = 0.1 are common. Here, topological entropy plots are drawn for different ranges of parameter c.
\n
Figure 18.
Upper row plots are for LCE’s and lower row plots are for topological entropies. Plots with (a), (b), (c) are respectively corresponds to the cases \n\nt\n\n = 3, 4, 5. Parameters \n\na\n\n = 25, \n\nb\n\n = 0.1 are common for all the plots. Then, for (b) & (c) LCE’s plots, \n\nc\n\n = 0.2, \n\nd\n\n = 0.15 and that for plot (c) , \n\nc\n\n = 0.28, \n\nd\n\n = 0.12. For lower row topological entropy plots, except parameter t, parameters \n\na\n\n = 25, \n\nb\n\n = 0.1, \n\nd\n\n = 0.15 are common for all.
\n
When parameters c and d both were allowed to vary, one gets 3D plots for topological entropies as shown here in \nFigure 19\n.
\n
Figure 19.
3D plots for topological entropy variations. Parameters values are taken as \n\na\n\n = 25, \n\nb\n\n = 0.1 and then 0 ≤ \n\nc\n\n ≤ 0.5 & 0 ≤ \n\nd\n\n ≤ 0.5.
\n
\nCorrelation dimensions:
\n
Being one of the characteristic invariants of nonlinear system dynamics, the correlation dimension provides measure of dimensionality for the underlying attractor of the system. A statistical method used to determine correlation dimension. It is an efficient and practical method in comparison to others, like box counting etc. The procedure to obtain correlation dimension follows from steps of calculations in [73]:
\n
For case \n\nt\n\n = 3 and \n\na\n\n = 25, \n\nb\n\n = 0.1, \n\nc\n\n = 0.28, \n\nd\n\n = 0.12, correlation integral data calculated and its plot is obtained, \nFigure 20\n. The linear fit of correlation integral data obtained as
\n
Figure 20.
Plot of correlation integral curve for t = 3 and a = 25, b = 0.1, c = 0.28, d = 0.12.
\n
\n\nY\n=\n0.0581323\nx\n−\n0.580866\n\n
\n
The y-intercept of this straight line is 0.580866. Therefore the correlation dimension of the attractor in this case is, approximately, \n\n\nD\nc\n\n\n = 0.581.
\n
Computation of correlation dimension carried out for more cases for different set of values of parameters as shown in \nTable 1\n.
\n
\n
\n
\n
\n
\n
\n
\n\n
\n
Cases (t)/Parameters
\n
a
\n
b
\n
c
\n
d
\n
Approximate Dc\n
\n
\n\n\n
\n
t = 3
\n
25
\n
0.1
\n
0.28
\n
0.12
\n
0.581
\n
\n
\n
t = 4
\n
25
\n
0.1
\n
0.18
\n
0.18
\n
0.645
\n
\n
\n
t = 5
\n
25
\n
0.1
\n
0.18
\n
0.18
\n
0.703
\n
\n
\n
t = 4
\n
25
\n
0.1
\n
0.28
\n
0.12
\n
0.676
\n
\n
\n
t = 5
\n
25
\n
0.1
\n
0.28
\n
0.12
\n
0.772
\n
\n
\n
t = 3
\n
35
\n
0.1
\n
0.2
\n
0.2
\n
0.877
\n
\n
\n
t = 4
\n
35
\n
0.1
\n
0.2
\n
0.2
\n
0.618
\n
\n
\n
t = 5
\n
35
\n
0.1
\n
0.2
\n
0.2
\n
1.264
\n
\n\n
Table 1.
Correlation Dimensions for different sets of parameters.
\n
\n
\n
2.2.2 Complexities in micro-economic Behrens Feichtinger model
\n
Investigation on microeconomic chaotic disturbances and certain measure to control chaos appeared in some recent articles, [72, 93, 94, 95], extended here for complexity analysis. The problem proposed as an micro economic model of two firms X and Y competing on the same market of goods having asymmetric strategies. The sales \n\n\nx\nn\n\n\n and \n\n\ny\nn\n\n\n of both firms are evolving in discrete time steps.
where \n\nα\n,\nβ\n\n (\n\n0\n<\nα\n,\nβ\n<\n1\n\n) are the time rates at which the sales of both firm decays in the absence of investments. Parameters \n\na\n,\nb\n\n describe the investment effectiveness of both the firms. Parameter \n\nc\n\n is an “elasticity” measure of the investment strategies. For parameter values \n\nα\n\n = 0.46¸ \n\nβ\n\n = 0.7, \n\na\n\n = 0.16, \n\nb\n\n = 0.9, \n\nc\n\n = 105, we have observed the chaotic attractor of this model.
\n
\nBifurcation Diagram:
\n
Bifurcation diagrams for system (9) obtained for \n\nα\n\n = 0.46¸ \n\nβ\n\n = 0.7, \n\na\n\n = 0.16, \n\nb\n\n = 0.9 and by varying parameter \n\nc\n\n, 8 ≤ \n\nc\n\n ≤ 160 and in close range, 6 ≤ \n\nc\n\n ≤ 8, \nFigure 21\n. Then, again it obtained for values \n\nα\n\n = 0.46¸ \n\nβ\n\n = 0.7, \n\na\n\n = 0.16, \n\nb\n\n = 0.6, \n\nc\n\n = 110 and 0 ≤ \n\na\n\n ≤ 0.4, \nFigure 22\n. Appearance of period doubling followed by chaos visible from these figures.
\n
Figure 21.
Bifurcation diagrams of system (9) with respect to coordinates x and y. Lower plots are correspond to bifurcations in close range to indicate the appearance of periodic windows within bifurcation. \n\nα\n\n = 0.46¸ \n\nβ\n\n = 0.7, \n\na\n\n = 0.16, \n\nb\n\n = 0.9, 8 ≤ \n\nc\n\n ≤ 160 & 6 ≤ \n\nc\n\n ≤ 8.
\n
Figure 22.
Bifurcation of map (9) α = 0.46¸ β = 0.7, a = 0.16, b = 0.6, c = 110 and 0 ≤ a ≤ 0.4
\n
Attractors:
\n
Time series plots and a plot of chaotic attractor obtained for values \n\na\n\n = 0.16, \n\nb\n\n = 0.9, \n\nc\n\n = 105, α = 0.46, β = 0.7 of system (9) shown in \nFigure 23\n. Plots shown in \nFigure 24\n are of LCEs for the chaotic motion.
\n
Figure 23.
Time series plots and chaotic attractor of the system (9) for \n\na\n\n = 0.16, \n\nb\n\n = 0.9, \n\nc\n\n = 105, α = 0.46, β = 0.7 and initial condition (0.1, 0.1).
\n
Figure 24.
Plots of Lyapunov exponents for chaotic evolution of the system (9) for \n\na\n\n = 0.16, \n\nb\n\n = 0.9, \n\nc\n\n = 105, α = 0.46, β = 0.7.
\n
\nTopological Entropies: Topological entropies calculated numerically and plotted. These are shown in \nFigure 25\n. One finds significant increase topological entropy where the system shows regularity, (e.g., 20 ≤ c ≤ 75), and for values α = 0.46, β = 0.7, a = 0.16 and b = 0.9. This shows presence of complexities though there is no chaos.
\n
Figure 25.
Plots of topological entropies: (a) left 2D plot is obtained for 12 ≤ c ≤ 170 and values of a = 0.16, b = 0.9, α = 0.46 and β = 0.7 and (b) right 3D plot is for 120 ≤ c ≤ 150 and 0 ≤ a ≤ 0.4 keeping same values for α and β.
\n
\nCorrelation dimension:\n
\n
Following steps used for map (8), correlation dimension of chaotic the attractor for values α = 0.46, β = 0.7, \n\na\n\n = 0.16, \n\nb\n\n = 0.9, \n\nc\n\n = 105, obtained as \n\n\nD\nc\n\n\n = 0.064
\n
\n
\n
2.2.3 Continuous Volterra-Petzoldt Model
\n
A continuous 2-dimensional Lotka – Volterra type predator− prey model of constant period chaotic amplitude, (UPCA model), proposed by Petzoldt, [96] based on works, [97, 98], written as
Bifurcation diagram for predator z while varying prey parameter b shown there, Petzoldt [86], is interesting. Periodic bifurcations and chaotic attractor of this model for different parameter space are presented in the figure, \nFigure 26\n.
\n
Figure 26.
Periodic bifurcations and chaotic attractor formations of Volterra – Petzoldt model for different values of c fixed parameters \n\na\n\n = 1, \n\nb\n\n = 1, α 1 = 0.205, α 2 = 1, \n\nk\n\n\n1 = 0.05, \n\nk\n\n\n2 = 0, \n\nw\n\n = 0.006.
\n
Plots of time series for x(t), for cases of chaos, are given in \nFigure 27\n and that of Lyapunov exponents, (LCEs), of chaotic attractors shown in last two plots in \nFigure 28\n.
\n
Figure 27.
Plots of time series curves for x(t) for chaotic evolutions for values of c. Other parameters are same as in \nFigure 26\n.
\n
Figure 28.
Plots of LCEs of chaotic attractors of model (1) for values of \n\nc\n\n. Other parameters are same as in \nFigure 26\n.
\n
In conclusion, one observes that the system (10) evolve into chaos after period doubling phenomena.
\n
\n
\n
\n
\n
3. Chaos control technique
\n
As nonlinear systems are hardly comparable in the sense that behavior of one nonlinear system hardly match with another nonlinear system so the chaotic evolutions. So controlling chaos to bring any chaotic system to regularity may differ from one nonlinear system to another nonlinear system. Different types of controlling chaos technique discussed in recent literatures, [75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88].
\n
Following two chaos controlling technique discussed here:
\n
\n
3.1 Asymptotic Stability Method
\n
Asymptotic stability analysis to stabilize unstable fixed point and to control chaotic motion appeared in some recent researches, [83, 84, 85]. Though this method has some limitations, it is perfect way to control chaos in models where it can be applicable.
\n
\nDescription of the Method:\n
\n
Dynamics of the actual map X\n\nn + 1\n and that of the desired map Y\n\nn + 1\n can be explained by following mapping:
Let \n\na\n\n, \n\nb\n\n are two parameters of the system and (\n\n\nx\nn\n\n\n, \n\n\ny\nn\n\n\n ) be any unstable fixed point of above system for given values of \n\na\n\n and \n\nb\n\n. Then, our objective is to obtain two new values for \n\na\n\n and \n\nb\n\n so that this unstable point becomes stable. For this, we need the Jacobian matrices defined by
Note that in equation (13) and (14) the coefficient matrices C\n\nR\n, C\n\nD\n and C\n\nM\n are to be determined so that if the error vector e\n\nn\n= X\n\nn\n\n-Y\n\nn\n is initialized as e\n\n0\n= 0, then it will be zero for all n future times. For asymptotic stability, we must have e\n\nn\n → 0 as n → ∞, then equation (14) implies
For \n\na\n\n = 3.7, \n\nb\n\n = 3.5, \n\nc\n\n = 0.2, one obtains four fixed points obtained as: (0, 0), (0, −4.0), (0.72973, 0) & (0.25712, 0.49961) of which (0.25712, 0.49961) is unstable. So, the orbits originating nearby it would also be unstable and unpredictable & may be chaotic. Nearby this unstable fixed point, we assume a desired initial point as (0.3, 0.5). With this as initial point together with parameters \n\na\n\n = 3.7, \n\nb\n\n = 3.5, \n\nc\n\n = 0.2, time series, attractor and LCE plots are obtained and shown by \nFigure 29\n. Clearly the system (18) is showing chaos at (0.3, 0.5) with \n\na\n\n = 3.7, \n\nb\n\n = 3.5, \n\nc\n\n = 0.2.
\n
Figure 29.
Time series graphs, attractor and LCE plots of the unstable system.
\n
Then, applying asymptotic stability discussed above for the map (18). For fixed value c = 0.2, unstable fixed point obtained as (0.25712, 0.49961). Nearby this point take initial point (0.3, 0.5) and \n\n\np\n∗\n\n=\n\n\n\n\na\n\n\n\n\nb\n\n\n\n\n=\n\n\n\n\n3.7\n\n\n\n\n3.5\n\n\n\n\n\n. When above-mentioned method applied, one obtains matrices:
For the case when \n\nc\n\n = 0.2; new values of \n\na\n\n and \n\nb\n\n; \n\na\n\n = 3.91525, \n\nb\n\n = 2.99538 along with initial point (0.3, 0.5)a phase plot and a plot of Lyapunov exponents (LEC), are given in \nFigure 30\n.
\n
Figure 30.
Phase plot and LCE plot of controlled system when \n\nc\n\n = 0.2, \n\na\n\n = 3.91525, \n\nb\n\n = 2.99538.
\n
\n
\n
3.2.2 Food chain model
\n
\nNext, we have considered three dimensional food chain model, [23], written as
For values \n\na\n\n = 4.1, \n\nb\n\n = 3.7, \n\nc\n\n = 3, \n\nd\n\n = 3.5, \n\nr\n\n = 3.8 five fixed points exist for system (19) given by: P0(0, 0, 0), P1(0, 0.2632, 0.2857), P2(0.518614, 0.263158, 0.158812), P3(0.7561, 0, 0) and P4(0.3333, 0.4685, 0). Then, by stability analysis it has obtained that the fixed points P2(0.518614, 0.263158, 0.158812) and P4(0.3333, 0.4685, 0) are unstable. Then, taking nearby P2, a desired initial point P*(0.5, 0.3, 0.2), chaotic attractors drawn, \nFigure 31\n.
\n
Figure 31.
Time series and attractors of unstable system.
\n
In the process of stabilizing the desired point (0.5, 0.3, 0.2), calculations performed to replace parameters \n\na\n\n = 4.1, \n\nd\n\n = 3.5 and \n\nr\n\n = 3.8 to earlier case of map (18). After obtaining all concerned matrices, replacement matrix obtained as
At these new parameter values of \n\na\n\n, \n\nd\n\n and \n\nr\n\n, the phase plot and the plot of Lyapunov exponents of map (19) obtained, \nFigure 32\n. These show chaotic motion controlled and the system returns to regularity.
\n
Figure 32.
Phase plot and LCE plot of map (19) showing regular motion and chaos is controlled.
\n
\n
3.2.2.1 Pulsive Feedback Technique to Chaos Control
\n
Pulsive chaos control technique is discussed in detail in recent articles, [86, 87, 88]. As an application of this technique let us consider a simple 2 – dimension discrete time Burger’s map
where \n\na\n\n and \n\nb\n\n are non-zero parameters . This map evolve chaotically when \n\na\n\n= 0.9, \n\nb\n\n=0.856. To control chaotic motion we have used pulsive feedback control technique, Litak et al. [86] by
\n
Here (−0.9, 0.948683) is an unstable fixed point of the original Burger\'s map. It has been observed that above chaotic motion is controlled and display regular behavior after re-writing equations (1) as follows:
Repeating stability analysis for system (2) with the fixed point (−0.9, 0.948683), one finds this point be stable if ε < 0.45. So, taking ε = 0.435, phase plot obtained as shown in \nFigure 34\n, indicates chaotic motion, \nFigure 33\n, is now controlled.
\n
Figure 33.
Chaos in Burgerger’s map for a = 1, b = 0.9.
\n
\n
\n
3.2.4 Controlling Chaos in Volterra-Petzoldt Map
\n
Evolution of Volterra-Petzoldt map already discussed in Section 2, Eq. (10). For parameters \n\na\n\n = 1, \n\nb\n\n = 1, \n\nc\n\n = 9.7, \n\n\nα\n1\n\n\n = 0.205, \n\n\nα\n2\n\n\n = 1, \n\n\nk\n1\n\n\n = 0.05, \n\n\nk\n2\n\n\n = 0 , \n\nw\n\n = 0.006, this map shows chaotic motion. An unstable equilibrium solution P* (19.5374, 9.64328, 1.02602) exists in this case.
\n
Applying the method of pulsive feedback, and re-writing eq. (10) as
Then, using stability analysis, for stabilize the above unstable point P*, one obtains the parameter ε = −0.45.
\n
\n
\n
\n
\n
4. Discussions
\n
Regular and chaotic evolutions observed in some 1-3 dimensional discrete and continuous nonlinear models, which have applications in different areas of science. Presence of complexity in these systems viewed by indications of significant increase in topological entropies in certain parameter spaces. More increase in topological entropy in a system signified the system is more complex. Bifurcation phenomena for different systems show interesting properties like bistability, folding, intermittency, chaos adding etc. which are not common to all nonlinear systems. Proper numerical simulations performed for each system to obtain regular and chaotic attractors, Lyapunov exponents (LCEs) as a measure of chaos, (evolution is regular if LCE < 0 and chaotic if LCE > 0), topological entropies and correlation dimensions for chaotic attractors. It appears from the plots of topological entropies that obtained for discrete models that complexity exists even in absence of chaos. Correlation dimensions obtained for chaotic attractors are non-integers because these attractors bear fractal properties. A chaotic attractor is composed of complex pattern and so, in a variety of nonlinear evolving systems measurement of topological entropy is equally important, [63, 64, 65, 66, 67].
\n
To control chaotic motion, techniques of asymptotic stability analysis and that of pulsive feedback control applied here. Pulsive control technique applied to Volterra-Petzoldt map (10) and to Burger’s map (20), show chaos successfully controlled and systems returned to regularity, \nFigures 34\n and \n35\n. Application of Pulsive control method perfectly controlled chaotic motions in systems (10), (20) shown here. Chaos is also controlled by this method for system (10), [72]. Asymptotic stability analysis method applied to a prey-predator system and to a food chain model, respectively, to maps (18) and (19), and chaos effectively controlled shown, respectively, through figures, \nFigures 30\n and \n32\n. Asymptotic stability analysis technique has some limitations explained in the articles where this method proposed, [83, 84]. Though there are many ways to control chaos in dynamical systems, [74], both the techniques applied here are perfect and very effective in controlling chaos, especially in real systems.
\n
Figure 34.
Plot of regular attractor for \n\na\n\n = 1, \n\nb\n\n = 0.9 and ε = 0.435.
\n
Figure 35.
Plots of chaotic attractor changing into regular attractor by application of pulsive feedback technique.
\n
\n
Acknowledgments
\n
The author wishes to present his sincere gratitude to Professor M.K. Das of Institute of Informatics & Communication, University of Delhi South Campus, for his all support and help in preparation of this article.
\n
\n',keywords:"chaos, Lyapunov exponents, chaos indicator, bifurcation, topological entropy, correlation dimension",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/74033.pdf",chapterXML:"https://mts.intechopen.com/source/xml/74033.xml",downloadPdfUrl:"/chapter/pdf-download/74033",previewPdfUrl:"/chapter/pdf-preview/74033",totalDownloads:373,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:52,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"July 27th 2020",dateReviewed:"October 2nd 2020",datePrePublished:"December 2nd 2020",datePublished:"April 14th 2021",dateFinished:"November 12th 2020",readingETA:"0",abstract:"Chaotic phenomena and presence of complexity in various nonlinear dynamical systems extensively discussed in the context of recent researches. Discrete as well as continuous dynamical systems both considered here. Visualization of regularity and chaotic motion presented through bifurcation diagrams by varying a parameter of the system while keeping other parameters constant. In the processes, some perfect indicator of regularity and chaos discussed with appropriate examples. Measure of chaos in terms of Lyapunov exponents and that of complexity as increase in topological entropies discussed. The methodology to calculate these explained in details with exciting examples. Regular and chaotic attractors emerging during the study are drawn and analyzed. Correlation dimension, which provides the dimensionality of a chaotic attractor discussed in detail and calculated for different systems. Results obtained presented through graphics and in tabular form. Two techniques of chaos control, pulsive feedback control and asymptotic stability analysis, discussed and applied to control chaotic motion for certain cases. Finally, a brief discussion held for the concluded investigation.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/74033",risUrl:"/chapter/ris/74033",book:{id:"10413",slug:"a-collection-of-papers-on-chaos-theory-and-its-applications"},signatures:"Lal Mohan Saha",authors:[{id:"328237",title:"Prof.",name:"Lal Mohan",middleName:null,surname:"Saha",fullName:"Lal Mohan Saha",slug:"lal-mohan-saha",email:"lalmohan.saha@snu.edu.in",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Dynamic models with chaos and complexity",level:"1"},{id:"sec_2_2",title:"2.1 One dimensional discrete models",level:"2"},{id:"sec_2_3",title:"2.1.1 Dynamics of laser map",level:"3"},{id:"sec_3_3",title:"2.1.2 Dynamics of biological red cells model",level:"3"},{id:"sec_5_2",title:"2.2 Two-dimensional models",level:"2"},{id:"sec_5_3",title:"Table 1.",level:"3"},{id:"sec_6_3",title:"2.2.2 Complexities in micro-economic Behrens Feichtinger model",level:"3"},{id:"sec_7_3",title:"2.2.3 Continuous Volterra-Petzoldt Model",level:"3"},{id:"sec_10",title:"3. Chaos control technique",level:"1"},{id:"sec_10_2",title:"3.1 Asymptotic Stability Method",level:"2"},{id:"sec_11_2",title:"3.2 Applications",level:"2"},{id:"sec_11_3",title:"3.2.1 Chaos Control in a 2–Dimensional Prey-Predator map",level:"3"},{id:"sec_12_3",title:"3.2.2 Food chain model",level:"3"},{id:"sec_12_4",title:"3.2.2.1 Pulsive Feedback Technique to Chaos Control",level:"4"},{id:"sec_14_3",title:"3.2.3 Controlling Chaos in 2-D Burger’s Map",level:"3"},{id:"sec_15_3",title:"3.2.4 Controlling Chaos in Volterra-Petzoldt Map",level:"3"},{id:"sec_18",title:"4. Discussions",level:"1"},{id:"sec_19",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\nPoincaré, H. (1957): Les Methodes Nouvelles de la Mecanique Celeste. Dover, New York (1957) Paris, 1899; reprint.\n'},{id:"B2",body:'\nLorenz EN. Deterministic non-periodic flow. Journal of the Atmospheric Sciences. 1963;20(2):130-141\n'},{id:"B3",body:'\nSharkovskii, A. N. (1964).: Co-existence of cycles of a continuous mapping of the line into itself. Ukrainian Math. J. 16: 61–71.\n'},{id:"B4",body:'\nSmale, S.: Differentiable dynamical systems. Bull. Amer. Math. with Soc., 1967; 73 (6), 747--817.\n'},{id:"B5",body:'\nHènon M. Numerical study of quadratic area-preserving maoings. Quart. J. Math. 1969;27:291-311\n'},{id:"B6",body:'\nRuelle D, Takens F. On the nature of turbulence. Commun. Math. Phys. 1971;20:167-192\n'},{id:"B7",body:'\nGuckenheimer, J., Holmes, P. (1971): Nonlinear Oscillations Dynamical Systems, and Bifurcations of Vector Field. Applied Mathematical Sciences, Book Series, Springer.\n'},{id:"B8",body:'\nMay RM. Stability and Complexity in Model Ecosystem. Princeton N. J: Princeton University Press; 1974\n'},{id:"B9",body:'\nLi T-Y, Yorke JA. Period Three Implies Chaos. The American Mathematical Monthly. 1975. DOI: https://doi.org/10.2307/2318254\n'},{id:"B10",body:'\nMay RM. Simple mathematical models with very complicated dynamics. Nature. 1976;261:459-467\n'},{id:"B11",body:'\nRössler OE. An equation for hyperchaos. Physics Letters A. 1979;71:155-157\n'},{id:"B12",body:'\nK. Ikeda, H. Daido and O. Akimoto: Chaotic behavior of transmitted light from a ring cavity. Phys. Rev. Lett., 1980; 45 (9), 709 – 712.\n'},{id:"B13",body:'\nFeigenbaum MJ. Universal behavior in nonlinear systems. Physica. 1983;7D:16-39\n'},{id:"B14",body:'\nGleick, J. (1987). “Chaos: Making a New Science”.\n'},{id:"B15",body:'\nF. C. Moon (1987): Chaotic Vibrations., John Wiley & Sons New York 1987\n'},{id:"B16",body:'\nDevaney RL. An Introduction to Chaotic Dynamical System. Reading: Addison-Wesley; 1989\n'},{id:"B17",body:'\nUeda Y. Randomly transitional phenomena in the system governed by Duffing\'s equation. J. Stat. Phys. 1979;20:181-196\n'},{id:"B18",body:'\nStewart I. Does God Play Dice? Penguin Books; 1989\n'},{id:"B19",body:'\nTanaka Y and Saha LM. (2012): Nonlinear Behaviors of Pulsating Stars with Convective Zones. PASJ: Publ. Astron. Soc. Japan 2012;64, L8-1- 4.\n'},{id:"B20",body:'\nLotka AJ. Elements of Physical Biology. Baltimore MD: Williams and Wilkins; 1925\n'},{id:"B21",body:'\nVolterra, V. (1931): .Lecons sur la Thorie Mathmatique de la Lutte pour la Vie, Gauthiers-Viallars, Paris.\n'},{id:"B22",body:'\nAllee WC. Animal aggregations. The Quarterly Review of Biology. 1927;2:367-398\n'},{id:"B23",body:'\nAllee WC, Bowen E. Studies in animal aggregations: mass protection against colloidal silver among goldfishes. Journal of Experimental Zoology. 1932;61(2):185-207\n'},{id:"B24",body:'\nElsadany AA. Dynamical complexities in a discrete-time food chain. Computational Ecology and Software. 2012;\n2\n(2):124-139\n'},{id:"B25",body:'\nSmith M. Mathematical Ideas in Biology. Cambridge: Cambridge University Press; 1968\n'},{id:"B26",body:'\nFreedman HI. Deterministic Mathematical Models in Population Ecology. Marcel Dekker; 1980\n'},{id:"B27",body:'\nJ.R. Beddington, C.A. Free and J.H. Lawton. Dynamic complexity in predator–prey models framed in difference equations, Nature. 1975;255:58-60.\n'},{id:"B28",body:'\nAbrams PA, Ginzburg LR. The nature of predation: prey dependent, ratio dependent or neither? Trends in Ecology & Evolution. 2000;15(8):337-341\n'},{id:"B29",body:'\nGrafton, R.Q., Silva-Echenique J. (1994). Predator–Prey Models: Implications for Management. Atlantic Canada Economics Association Papers 23, pp. 61–71.\n'},{id:"B30",body:'\nKaitala V, Heino M. Complex non-unique dynamics in ecological interactions. Proc R Soc London B. 1996;263:1011-1015\n'},{id:"B31",body:'\nQuentin Grafton R, Silva-Echenique J. How to manage nature? Strategies, predator-prey models, and chaos. Marine Resource Economics. 1997;12(2):127-143\n'},{id:"B32",body:'\nYakubu A-A. Prey dominance in discrete predator-prey systems with a prey refuge. Mathematical Biosciences. 1997;144:155-178\n'},{id:"B33",body:'\nXiao Y, Cheng D, Tang S. Dynamic complexities in predator–prey ecosystem models with age-structure for predator. Chaos, Solitons and Fractals. 2002;14:1403-1411\n'},{id:"B34",body:'\nLiu X, Xiao D. Complex dynamic behaviors of a discrete-time predator-prey system. Chaos, Solitons & Fractals. 2007;32:80-94\n'},{id:"B35",body:'\nAndrecut, M. and Kauffman, S. A. Chaos in a Discrete Model of a Two-Gene System. Physics Letters A. 2007;367, 281-287.\n'},{id:"B36",body:'\nCanan C¸ elik, Oktay Duman. Allee effect in a discrete-time predator–prey system. Chaos, Solitons & Fractals, 2009; 40, 1956–1962.\n'},{id:"B37",body:'\nHadeler KP, Freedman HI. Predator-prey populations with parasitic infection. Journal of Mathematical Biology. 1989;27(6):609-631\n'},{id:"B38",body:'\nDanca M, Codreanu S, Bako B. Detailed analysis of a nonlinear predator-prey model. Journal of Biological Physics. 1997;23(1):11-20\n'},{id:"B39",body:'\nWan-Xiong, Yan-Bo-Zhang and Chang-zhong Liu. Analysis of a discrete-time predator-prey system with Allee effect. Ecological Complexity, 2011, 8: 81 – 85.\n'},{id:"B40",body:'\nZhao M, Yunfei D. Stability of a discrete-time predator-prey system with Allee effect. Nonlinear Analysis and Differential Equations. 2016;4(5):225-233\n'},{id:"B41",body:'\nXian-wei X-l F, Jing Z-j. Dynamics in a discrete-time predator-prey system with Allee effect. Acta Mathematicae Applicatae Sinica. 2013;20:143-164\n'},{id:"B42",body:'\nStephens PA, Sutherland WJ, Freckleton RP. What is the Allee effect? Oikos. 1999;87:185-190\n'},{id:"B43",body:'\nTang S, Chen LA discrete predator–prey system with age-structure for predator and natural barriers for prey. Mat. Model. Numer. Anal. 2001;35:675-690\n'},{id:"B44",body:'\nTang S, Chen L. Density-dependent birth rate, birth pulses and their population dynamic consequences. J. Math. Biol. 2001;44(2):185-199\n'},{id:"B45",body:'\nW. Weaver,(1948): “Science and complexity,” American Scientist, vol. 36, no. 4, p. 536.\n'},{id:"B46",body:'\nGribbin, J (2004) Deep Simplicity: Chaos, Complexity and the Emergence of Life. Penguin Press Science.\n'},{id:"B47",body:'\nSimon HA. The architecture of complexity. Proceedings of the American Philosophical Society. 1962;106(6):467-482\n'},{id:"B48",body:'\nGribble, S. 1995, Topological Entropy as a Practical Tool for Identification and Characterization of Chaotic System. Physics 449 Thesis.\n'},{id:"B49",body:'\nIwai K. Continuity of topological entropy of one dimensional map with degenerate critical points. J. Math. Sci. Univ. Tokyo. 1998;5:19-40\n'},{id:"B50",body:'\nHefferman DM. Multistability, intermittency and remerging Feigenbaum trees in an externally pumped ring cavity laser system. Phys. Lett.A. 1985;108:413-422\n'},{id:"B51",body:'\nWalby S. Complexity theory, systems theory, and multiple intersecting social inequalities. Philosophy of the Social Sciences. 2007;37(4):449-470\n'},{id:"B52",body:'\nBenettin G, Galgani L, Giorgilli A, Strelcyn JM. Lyapunov Characteristic Exponents for smooth dynamical systems and for Hamiltonian systems; a method for computing all of them. Part 1 & 2: Theory. Meccanica. 1980;15:9-30\n'},{id:"B53",body:'\nKatok A. Lyapunov exponents, entropy and periodic orbits for diffeomorphisms. Publ. Math. IHES. 1980;51:137-174\n'},{id:"B54",body:'\nP. Grassberger and Itamar Procaccia. "Measuring the Strangeness of Strange Attractors". Physica D: Nonlinear Phenomena, 1983;9 (1–2): 189–208.\n'},{id:"B55",body:'\nGrassberger P, Procaccia I. Characterization of Strange Attractors. Physical Review Letters. 1983;50(5):346-349\n'},{id:"B56",body:'\nBryant P, Brown R, Abarbanel H. Lyapunov exponents from observed time series. Physical Review Letters. 1990;65(13):1523-1526\n'},{id:"B57",body:'\nBrown R, Bryant P, Abarbanel H. Computing the Lyapunov spectrum of a dynamical system from an observed time series. Phys. Rev. A. 1991;43:2787-2806\n'},{id:"B58",body:'\nAbarbanel HDI, Brown R, Kennel MB. Local Lyapunov exponents computed from observed data. Journal of Nonlinear Science. 1992;2(3):343-365\n'},{id:"B59",body:'\nSkokos C. The Lyapunov characteristic exponents and their computation. Lect. Notes. Phys. 2009;790:63-135\n'},{id:"B60",body:'\nSyta A, Litak G, Budhraja M, Saha LM. Detection of the chaotic behavior of a bouncing ball by 0 – 1 test. Chaos, Solitons & Fractals. 2009;42:1511-1517\n'},{id:"B61",body:'\nAdler RL, Konheim AG, McAndrew MH. Topological entropy. Trans. Amer. Math. Soc. 1965;114:309-319\n'},{id:"B62",body:'\nNagashima H, Baba Y. Introduction to Chaos: Physics and Mathematics of Chaotic Phenomena. Overseas Press India Private Limited; 2005\n'},{id:"B63",body:'\nBowen R. Topological entropy for noncompact sets. Trans. Amer. Math. Soc.1973;184:125-136\n'},{id:"B64",body:'\nHolmes P. ‘Strange’ phenomena in dynamical systems and their physical implications. App. Math. Modelling. 1977;7(1):362-366\n'},{id:"B65",body:'\nP. Holmes (1979) A nonlinear oscillator with a strange attractor, Phil. Trans. Roy. Soc.Lond.\nA 292(1394): 419 – 448.\n'},{id:"B66",body:'\nBalmforth NJ, Spiegel EA, Tresser C. Topological entropy of one dimenonal maps: approximations and bounds. Phys. Rev. Lett. 1994;72:80-83\n'},{id:"B67",body:'\nStewart L, Edward ES. Calculating topological entropy. J. Stat. Phys. 1997;89:1017-1033\n'},{id:"B68",body:'\nYuasa M, Saha LM. Indicators of chaos. Science and Technology, Kinki University. Japan. No. 2008;20:1-12\n'},{id:"B69",body:'\nSaha LM, Prasad S and Yuasa M Measuring Chaos: Topological Entropy and Correlation Dimension in Discrete Maps, Science and Technology, Vol. 24, 2012, pg. 10 – 23.\n'},{id:"B70",body:'\nDeCoster GP, Mitchell DW. The efficacy of the correlation dimension technique in detecting determinism in small samples. Journal of Statistical Computation and Simulation. 1991;39:221-229\n'},{id:"B71",body:'\nSaha LM, Sharma R. Dynamics of Two-Gene Andrecut-Kauffman System: Chaos and Complexity. Accepted. Italian Journal of Pure and Applied Mathematica (IJPAM). 2018;41:405-413\n'},{id:"B72",body:'\nSaha LM, Das MK. Complexities in Micro-Economic Behrens Feichtinger Model. Indian Journal of Industrial and Applied Mathematics. 2016;7(2):127-135\n'},{id:"B73",body:'\nM. Martelli (1999) Introduction to Discrete Dynamical Systems and Chaos, Wiley- Interscience\n'},{id:"B74",body:'\nGuanrong Chen and Xiaoning Dong (1998): From Chaos to Order: Methodologies, Perspectives and Applications. World Scientific, Singapore, New Jersey, London, Hong Kong.\n'},{id:"B75",body:'\nAuerbach D, Grebogi C, Ott E, Yorke JA. Controlling chaos in high dimensional systems. Phys. Rev. Lett. 1992;69:3479-3482\n'},{id:"B76",body:'\nErjaee GH, Atabakzade MH, Saha LM. Interesting synchronization-like behavior. Int. Jour. Bifur.. Chaos. 2004;14(4):1447-1453\n'},{id:"B77",body:'\nCarroll TL, Pecora LM. Cascading synchronized chaotic systems. Physica D. 1993;67:126-140\n'},{id:"B78",body:'\nChen G. Optimal control of chaotic systems. Int’l J. of Bifur. Chaos. 1994;4:461-463\n'},{id:"B79",body:'\nOtt E, Grebogi C, Yorke JA. Controlling chaos. Phys. Rev. Lett. 1990;64:1196-1199\n'},{id:"B80",body:'\nPan S, Yin F. Using chaos to control chaotic systems. Phys. Lett. A. 1997;231:173\n'},{id:"B81",body:'\nPyragas K. Continuous control of chaos by self-controlling feedback. Phys. Lett. A. 1992;170:421-428\n'},{id:"B82",body:'\nShinbrot T, Grebogi C, Ott E, Yorke JA. Using small perturbations to control chaos. Nature. 1993;363:411-417\n'},{id:"B83",body:'\nErjaee GH. On the asymptotic stability of a dynamical system. IJST, Transaction A. 2002;\n26\n(A1):131-135\n'},{id:"B84",body:'\nSaha LM, Erjaee GH and Budhraja M. Controlling chaos in 2-dimensional systems, Iranian Jour. Sci. Tech., Trans. A, 2004;28, No.A2, 219 – 226.\n'},{id:"B85",body:'\nSaha LM, Das MK, Bhardwaj R. Asymptotic stability analysis applied to price dynamics. Ind. J, Industrial and Appl, Math. (IJIAM). 2018;9(2):186-195\n'},{id:"B86",body:'\nLitak G, Ali M, Saha LM. Pulsating feedback control for stabilizing unstable periodic orbits in a nonlinear oscillator with a non-symmetric potential. Int. J. Bifur. Chaos. 2007;17:2797-2803\n'},{id:"B87",body:'\nLitak G, Borowiec M, Ali M, Saha LM, Friswell MI. Pulsive feedback control of a quarter car forced by a road profile. Chaos Soliton and Fractals. 2007;33:1672-1676\n'},{id:"B88",body:'\nG. Litak, L. M. Saha and M. Ali (2010): Continuous and Pulsive Feedback Control of Chaos, Recent Progress in Controlling Chaos, by Miguel A. F. Sanjuan and Celso Grebogi, World Scientific (eBooks), p. 337 – 369.\n'},{id:"B89",body:'\nO’Cairbre F, O’Farrell AG, O’Reilly A. Bistability, bifurcation and chaos in a laser system. Int. Jour. Bifurcation and Chaos. 1995;5(4):1021-1031\n'},{id:"B90",body:'\nBonifacio R, Lugiato LA. Bistable absorption in a ring cavity, Lett.l. Nuovo Cimento. 1978;21(15):505-510\n'},{id:"B91",body:'\nBenefacio R, Lugato LA. Theory of optical bistability. In: Dissipative Systems in Quantum Optics. Ed. R. Benefacio: Springer-Verlag; 1982. pp. 61-92\n'},{id:"B92",body:'\nde Souza SLT, Lima AA, Caldas IL, Medrano-T RO, Guimarães-Filho ZO. Self-similarities of periodic structures for a discrete model of a two-gene system. Physics Letter A. 2012;376:1290-1294\n'},{id:"B93",body:'\nHolyst JA, Hagel T, Haag G, Weidlich W. How to control chaotic economy? J. Evol. Econ. 1996;6:31-42\n'},{id:"B94",body:'\nBehrens DA. Feichtinger G., Prskawetz A. Complexity dynamics and control of arms race. European Journal of Operational Research, 1997;100:192-215\n'},{id:"B95",body:'\nPerc M. Microeconomic uncertainties cooperative allince and social welfare. Economics Letters. 2007;95:104-109\n'},{id:"B96",body:'\nThomas Petzoldt (2003): R as a simulation platform in ecological modelling. R. News, Vol. 3/3, 8 – 16.\n'},{id:"B97",body:'\nB. Blasius, A. Huppert and L. Stone. Complex dynamics and phase synchronization in spatially extended ecological systems. Nature, 1999;399:354 – 359.\n'},{id:"B98",body:'\nBlasius B, Stone L. Chaos and phase synchronization in ecological systems. Int. J. Bifur. And chaos. 2000;10:2361-2380\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Lal Mohan Saha",address:"lmsaha.msf@gmail.com",affiliation:'
Department of Mathematics, Shiv Nadar University, Gautam Budha Nagar, India
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1. Introduction
1.1 Characteristics of nitrogen assimilation in soybean
Currently, soybean seed production is increasing worldwide, and the annual production in 2019 was 334 million tons [1]. The percentage composition of soybean seeds is proteins (35%), lipids (19%), carbohydrates (28%), minerals (5%), and water (13%) [2]. Soybean plants originate from East Asia, and Asian people including the Japanese eat various kinds of traditional soy foods such as Tofu, Miso, Shoyu, Natto, etc. [3]. Traditional Eastern soy foods are now gradually accepted by Western people for promoting their health, as well as meat substitutes made from soybean. In addition, soybean seeds are very important for feeding livestock.
Because soybean seeds contain a higher amount of protein than cereals and other legume seeds, soybean requires a large amount of nitrogen for high seed yield [4]. One of soybean seeds production requires 70–90 kgN assimilation, therefore, the world average yield of 2.77 t ha−1 in 2019 requires as high as 200–250 kgN ha−1. Soybean plants depend on nitrogen fixation by root nodules (Ndfa), and the nitrogen is absorbed from soil (Ndfs) or fertilizer (Ndff) when applied. The N availability from soil mineralization during the soybean cultivation period varies widely depending on the soil fertility, but it is about 50 kgN ha−1 in Japan. Therefore, nitrogen fixation is the main source, and about 60–75% of N was derived from N derived from Ndfa in Niigata, Japan [5]. The root nodule is a symbiotic organ with soil bacteria, rhizobia. Figure 1A shows the photograph of nodulated roots of hydroponically cultivated soybean. Soybean nodules can be visible from 8 days after planting and grow and start to fix N2 around 15–20 DAP, when rhizobia were inoculated to seeds [6]. The cross-section of a soybean nodule is shown in Figure 1B. Infected rhizobia live in the red central zone of the nodule due to a high concentration of leghemoglobin, which bind to O2 supporting respiration and nitrogen fixation by rhizobia [6].
Figure 1.
Photographs of root nodules of hydroponically cultivated soybean. (A) Root nodules attached to the roots of soybean. (B) Cross-section of a soybean nodule.
Another characteristic of N assimilation in soybean is that soybean needs about 80% of N after the beginning of flowering, which is quite different from the paddy rice which assimilates only 20% of N is assimilated after heading [5]. Therefore, a long-lasting high nitrogen fixation activity after flowering is essential for high soybean seed yield. However, nitrogen fixation activity tends to decrease during the pod filling stage, due to competition of nutrients mainly photo-assimilate between seeds and nodules. Therefore, supplemental application of N fertilizers may be beneficial to support vigorous shoot growth and photosynthetic activity during the pod filling stage. However, a basal application of chemical N fertilizers often inhibits the nodule growth and nitrogen fixation activity, and they will be lost by nitrate leaching and denitrification. So, it is necessary to harmonize the N fertilization and N fixation to obtain a constant and high seed yield of soybean [7, 8].
1.2 Nitrogen inhibition on the growth and nitrogen fixation activity of soybean nodules
The inhibitory effects of combined nitrogen, especially nitrate, on nodule formation and nitrogen fixation of legumes have been studied for over 100 years [9]. According to Streeter’s review, the responses can be divided into three classes, the number of nodules per root, nitrogenase activity per unit mass of the nodules, and the nodule mass per plant [10]. The effects of nitrate concentration on the magnitude of the three responses are different. A relatively high nitrate concentration is required for the inhibition of nodule number per plant, followed by nitrogenase activity per nodule mass. The concentration effect on nodule mass is more sensitive than nodule number and nitrogen fixation activity, while low levels of nitrate stimulate nodule growth through the promotion of shoot growth.
Concerning the effects of nitrate on nodule growth, there are two different situations, the first is a direct effect or local effect in which nodules are in direct contact with the solution containing nitrate, and the second is an indirect or systemic effect in which nodules are not directly contacted with nitrate and nitrate is absorbed from the distant part of the roots [11]. In the direct effect, when soybean plants were hydroponically cultivated, the addition of 5 mM nitrate in culture solution rapidly stopped the individual nodule growth within one day as well as decreased N2 fixation activity measured by C2H2 reduction activity [12, 13].
Figure 2 shows the effect of 5 mM nitrate supply to the culture solution on the nodule growth of soybean plants. Soybean seeds were inoculated with Bradyrhizobium diazoefficiens (strain USDA110), germinated in a vermiculite bed, and the seedlings were cultivated in an N-free culture solution. The inoculated plants which had been cultivated with N-free culture solution were grown with 0 mM or 5 mM nitrate from 11 DAP (days after planting). The nodule growth with 0 mM nitrate grew from 1.23 mm diameter on 11 DAP to 3.00 mm on 19 DAP. On the other hand, the nodule with 5 mM nitrate grew from 1.03 mm on 11 DAP to 1.33 mm on 13 DAP, but the growth was almost completely stopped from 13DAP to 19 DAP. When 5 mM nitrate was removed from the culture solution back to N-free condition, the nodule growth and nitrogen fixation activity were quickly recovered in a day (Figure 3). The rapid and reversible inhibition of nodule growth by nitrate was similarly observed in the large size nodules and small nodules [12]. The quick and reversible nitrate inhibition on soybean nodules by nitrate supply was due to the decrease in the photo-assimilate supply from the shoot to nodules and it was conversely increased to the roots by isotope tracer experiments [13]. Imsande earlier reported the short-term exposure of 4 mM NO3− in hydroponic solution reversibly inhibited nitrogenase activity and nodule dry weight [14].
Figure 2.
Effect of 0 mM (A) or 5 mM (B) nitrate on the growth of nodules of hydroponically cultivated soybean from 11 days to 19 days after planting. (A) Root nodules attached to the roots of soybean cultivated with 0 mM NO3−. (B) Root nodules attached to the roots of soybean cultivated with 5 mM NO3−. (A) 0 mM NO3−, (B) 0 mM NO3−.
Figure 3.
Growth response of soybean nodules to 0 mM or 5 mM nitrate application in the culture solution. (A) Photographs of nodulated roots after nitrate treatments to 0 mM (blue arrows) or 5 mM nitrate (red arrows) from 10 DAP to 24 DAP. (B) Graphs of the changes in nodule diameter after nitrate treatments from 10 DAP to 24 DAP. (a) 0 mM NO3−, (b) 5 mM NO3−, and (c) 0,5,0 mM NO3−, white background: 0 mM NO3−, gray background: 5 mM NO3−. From Fujikake et al. [13].
As for the indirect or systemic effect of nitrate, Tanaka et al. [15] reported that nitrate supplied to one side of the split root system of soybean did not inhibit the nodule growth and nitrogen fixation activity of the other side of the roots supplied N-free medium. The upper and lower root systems were separated vertically by a two-layered pot system, the concentration and period of nitrate supply from lower roots gave a different effect on the nodule growth in the upper roots [16]. The long-term supply of a high concentration (5 mM) of nitrate from the lower roots inhibited the nodule growth (DW) of the upper roots, but the continuous supply of a low concentration (1 mM) of nitrate in the lower roots promoted the nodule growth in the upper roots through the increased in shoot growth and photosynthetic activity.
Concerning the chemical forms of N, the inhibitory responses were more sensitive to nitrate than to ammonium, and urea was only slightly inhibitory [17, 18]. The physiological meaning of the different responses to nitrogen compounds is not well understood. In this review, we would like to introduce recent advances in nitrate inhibition to nodule growth and nitrogen fixation activity first, and the effect of nitrate, ammonium, urea, and glutamine on the inhibition of nodule growth was compared.
2. Short-term effect of nitrate supply on nodule and root growth of soybean
Saito et al. [19] investigated the short-term responses of nodule growth to the 5 mM nitrate supply at one-hour intervals for 16 h under light and dark conditions (Figure 4A). Inoculated soybean plants were cultivated in a photo chamber under 16 h light at 28°C and 8 h dark at 18°C conditions. The nodule size is indicated by the nodule area (mm2) measured by a time-lapse camera and the nodule area measuring software NODAME [20, 21]. Under light conditions, the nodule growth of 13 DAP plants was constant from the start of light period to the end of the 16 h light. When 5 mM NO3− was applied under light conditions, the increase in the nodule area was the same until the initial 2 h and became significantly repressed after 7 h. The increase in the nodule area with 5 mM NO3− during the 16 h was about 60% of that with 0 mM NO3− under light conditions. This result indicated that nitrate inhibition on nodule growth begins very rapid at a few h after the addition of nitrate to the culture solution. Under dark conditions with 0 mM NO3− the nodule growth was more severely depressed (42% of 0 mM NO3− under light conditions at 16 h) than that treated with 5 mM NO3− under light conditions. The nodule growth was most severely repressed under dark conditions with 5 mM NO3− (25% of 0 mM NO3− under light conditions at 16 h) among treatments. These results support the former hypothesis that the addition of NO3− on the nodulated roots is repressed mainly through the decrease in photo-assimilate supply to the nodules because dark conditions repressed the nodule growth, and dark plus nitrate additively repressed the nodule growth.
Figure 4.
(A) Increase in nodule area with 0 mM or 5 mM NO3− under light or dark conditions, (B) Increase in primary root length with 0 mM or 5 mM NO3− under light or dark conditions, and (C) Increase in lateral root length with 0 mM or 5 mM NO3− under light or dark conditions. From Saito et al. [19].
Similar responses are observed in the increase in primary root growth with 0 mM or 5 mM NO3− under light or dark conditions (Figure 4B). The primary root growth was the fastest with 0 mM NO3− under light conditions, and that with 5 mM NO3− repressed (73% at 16 h), 0 mM NO3− under dark conditions (40% at 16 h), and 5 mM NO3− under dark conditions (29% at 16 h).
Interestingly, the opposite responses to nitrate were observed for the growth of lateral roots (Figure 4C). Under light conditions, the increase in the lateral roots with 5 mM NO3− was promoted to 121% of the 0 mM under light conditions. The increase in the lateral roots was repressed in 0 mM NO3− under dark conditions (51% at 16 h), but 5 mM NO3− still increased the lateral root growth under dark conditions compared with 0 mM NO3−.
Initial transport of photo-assimilate labeled with 11CO2 exposed to the matured leaf showed that 11C was leached to the roots and nodules within 1 h, and the distribution of photo-assimilate was higher in the root parts in contact with 5 mM NO3− solution compared with 0 mM NO3− solution [13]. Quantitative analysis of photo-assimilate transport was conducted using 14CO2 as a tracer, which was supplied to the whole shoot for 2 h, then the distribution of 14C was investigated among the organs of soybean plants supplied with 0 mM or 5 mM NO3−. The percentage distribution of 14C in roots and nodules was 5.2 and 9.1% of total fixed 14C in the plants with 0 mM NO3−, while those in the roots and nodules changed to 9.1 and 4.3%, respectively [13]. The increase in 14C was mainly in the lateral roots after supplying 5 mM NO3−, while 14C distribution in the primary roots was not changed between 0 mM and 5 mM NO3− [13].
The inhibitory effect of nitrate on nodule growth was shown to be reversible, and when 5 mM NO3− was changed to 0 mM NO3−, the nodule growth recovered in a day, when 5 mM NO3− treatment continued for 14 days [12]. This means the physiological function of nodules may be maintained under 5 mM NO3−, while the nodule growth was almost completely stopped. Figure 5 shows the 2D-PAGE of soybean nodule extract cultivated with 0 mM (A), and 5 mM NO3− (B) treatment from 10 DAP to 34 DAP. The patterns and intensities of the protein spots were similar between the 0 mM and 5 mM NO3− treatments after 24 days of treatment. Therefore, the functions of nodule were maintained under 5 mM NO3− conditions, although nodule growth and nitrogen fixation activity were strongly repressed. This might suggest that nodule function is not disintegrated in the nodule in direct contact with NO3−, whereas carbohydrate deficiency temporarily retard the nodule growth and nitrogen fixation activity. Therefore, after removal of NO3− from the culture solution quickly recovers the nodule growth and nitrogen fixation activity [12, 13].
Figure 5.
2D-Page of nodule soluble proteins with 0 mM (A) or 5 mM (B) nitrate. From Saito et al. [19].
3. Transcriptome and metabolome analyses of nitrate inhibition
The effect of nitrate supply on the gene expression and metabolite changes in nodules and roots were investigated by transcriptome and metabolome analysis [22]. After supplying 5 mM NO3− for 24 h to the nodulated soybean plants at 19 DAP, mRNA was extracted from the nodules and roots, and the cDNAs were hybridized with soybean oligo DNA microarray [22]. The results were compared with control plants supplied with 0 mM NO3−. Figure 6 shows the numbers of probe sets in the roots and nodules, which were up-regulated (4-fold, 2-fold) or down-regulated (4-fold, 2-fold) following 5 mM NO3− supply for 24 h compared with the control plants with 0 mM NO3−. The number in the 4-fold up-regulated probe sets in roots was 142 and higher than that in the nodules (78). The number of common probe sets 4-fold up-regulated both in roots and nodules was 9. On the other hand, the number of 4-fold down-regulated probe sets in the roots was 92 and lower than that in nodules (116). Similar trends were observed for the 2-fold up-regulation (C), and 2-fold down-regulation (D).
Figure 6.
Numbers of probe sets in the roots and nodules up-regulated or down-regulated by more than 4-fold or 2-fold following the addition of 5 mM nitrate to medium at the level of p < 0.05. From Ishikawa et al. [22].
The results showed that the 5 mM NO3− supply highly enhanced the gene expression in the roots related to nitrate transporter and metabolisms such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS), glutamate synthase (GOGAT), and Asparagine synthetase (AS) (Figure 7). The genes for ureide synthesis through purine synthesis and degradation in the roots were slightly increased. The gene expression related to nitrate transport and metabolism in nodules was also slightly promoted after NO3− supply, but not so high as in the roots. Figure 8 shows the ratios of gene expression related to C metabolism, glycolysis, and TCA cycle in roots (left) and nodules (right). The gene expression of the enzymes in glycolysis and TCA cycle in the roots were promoted by NO3−, while those in the nodules were mostly depressed.
Figure 7.
Comparison of the ratios of gene expression related to N metabolism in roots or root nodules with 5 mM or 0 mM nitrate (+N/−N). From Ishikawa et al. [22].
Figure 8.
Ratios of gene expression related to C metabolism (Glycolysis and TCA cycle in roots and nodules with 5 mM or 0 mM nitrate (+N/−N). From Ishikawa et al. [22].
Metabolome analysis was conducted using the same plants for the transcriptome analysis as above. The ratios of the concentrations of nitrogen compounds, phosphorus compounds, and organic acids concentrations in roots and nodules after 5 mM NO3− treatment were compared with 0 mM NO3− treatment as shown in Figure 9. Most of the nitrogen compounds in the roots were increased by NO3− treatment, especially allantoic acid (3.1-fold), glutamine (2.4-fold), and asparagine (2.1-fold). On the other hand, asparagine and N-acetylglucosamine in nodules were increased, but some amino acids were decreased such as alanine. For the phosphorous compounds, 5 mM NO3− treatment increased ATP concentration in the roots (3.9-fold) but decreased in nodules (0.7-fold). Similarly, most of the ratios of phosphorous compounds show over 1-fold in the roots, but less than 1-fold in nodules. The same was true in organic acids in roots and nodules.
Figure 9.
Ratios of N and P metabolite concentrations in roots and nodules with 5 mM or 0 mM nitrate (+N/−N). From Ishikawa et al. [22].
Both transcriptome and metabolome analysis indicated that NO3− treatment caused the promotion of C and N metabolism in the roots, while depressed C metabolism in the nodules. This agrees with the changes in the photo-assimilate supply from nodules to the roots [13].
4. Effects of nitrate, ammonium, urea, and glutamine on nodule growth and nitrogen fixation activity
In addition to the inhibitory effect of nitrate on nodule growth and nitrogenase activity, the repressive effect of ammonium is also reported [14], whereas urea did not reduce nodule dry weight and nitrogen fixation activity in hydroponically grown soybean [17, 18]. The difference in inhibitory effects by the forms of N compounds is not fully understood yet. Yamashita et al. [23] investigated the effect of various forms of nitrogen; nitrate, ammonium, urea, and glutamine on the quick and reversible inhibition of nodule growth and nitrogen fixation activity of soybean plants.
Soybean plants were cultivated in a nitrogen-free nutrient solution in a glass bottle, and nitrate, ammonium, glutamine, or urea (1 mM-N) were supplied from 12 days after planting (DAP) to 17 DAP. The increase in individual nodule growth expressed by nodule volume (mm3) was shown in Figure 10. The inhibitory effects on the nodule growth were severe in nitrate and ammonium treatments, and those by urea and glutamine were smaller than in nitrate and ammonium. On 17 DAP, the increase in nodule dry volume was low in nitrate and ammonium medium in urea and glutamine compared with the control with N-free solution. After N-based solutions were replaced by N-free solutions from 17 DAP to 24 DAP, the nodule growth in all treatments showed the recoveries. These results indicated that the rapid and reversible inhibition is not only by nitrate but also by ammonium, urea, and glutamine. Figure 11A shows the dry weight of nodules per plant on 17 DAP. The application of 1 mM-N of nitrate, ammonium, urea, and glutamine for 5 days depressed the nodule weight to 45, 75, 76, and 65% of the control nodules on 17 DAP. After N-free solution was supplied for 6 days following 5-day N treatment, the nodule dry weight on 24 DAP increased in all N treatments similar to the control plants (Figure 11B). Figure 11C shows the ARA per a single plant, and the activities were depressed in nitrate, ammonium, urea, and glutamine treatment like the decrease in the nodule dry weight (Figure 11A). The specific ARA per g DW of nodules on 17DAP were almost the same (Figure 11D), so the decrease in ARA per plant is due to lower nodule dry weight and not by a decline in the specific ARA. In this experiment, the DW and N concentrations of roots, stems, and leaves increased after 5 days of N application on 24 DAP compared with the control plants supplied with N-free solution.
Figure 10.
Changes in nodule volume from 12 to 24 DAP for treatments with control (N-free), nitrate, ammonium, urea, or glutamine from 12 to 17 DAP, thereafter cultivated with a N-free culture solution (Experiment 2). Shaded background indicates N treatment period, and white background indicates cultivation with N-free medium. Average and standard error are shown (n = 5). From Yamashita et al. [23].
Figure 11.
Comparison of the dry weight of nodules at 17 DAP (A) and at 24 DAP (B), and acetylene reduction activity per plant (C), and specific acetylene reduction activity per nodule g dry weight (D) on 17 DAP of soybean plants supplied with control (N-free), nitrate, ammonium, urea, or glutamine from 12 to 17 DAP, followed by supplying N-free solution from 17 DAP to 24 DAP. Averages and standard errors are shown (n = 4). Different letters above the column indicate significant differences at <0.05 by Tukey’s test. From Yamashita et al. [23].
15N-labeled 1 mM-N nitrate, ammonium, urea, or glutamine was supplied for 3 days from 21 to 24 DAP, in which the solutions were renewed every day. The whole shoot was enclosed in a plastic bag on 23 DAP, and 13CO2 was exposed to the plants for 1 h. Then the plants supplied with 15N and 13C were harvested on 24 DAP, 26 h after 13CO2 exposure. The labeling of 15N and 13C in each organ was determined by Mass spectrometry. The amount of 15N in nodules (Figure 12A) was 0.14 mg from nitrate-15N, 0.26 mg from ammonium-15N, 0.14 mg from urea-15N, and 0.29 mg from glutamine-15N. It is interesting to note that the amount of 15N in nodules is not related to the decrease in nodule DW (Figure 11A) and ARA (Figure 11C). Figure 12B shows the amount of 13C in nodules, and it was 85 mg in control, 27 mg in nitrate, 34 mg in ammonium, 54 mg in urea, and 34 mg in glutamine treatment. The decrease in the amount of 13C in nodules was similar to the nodule DW (Figure 11A) and ARA (Figure 11C) among treatments. This result supports the hypothesis that the depression of nodule growth and nitrogen fixation activity is related to the decline in photoassimilates partitioning but not N supply.
Figure 12.
(A) Amounts of N derived from 15N-labeled source in each tissue of soybean plants on 15 DAP supplied for 3 days from 21 to 24 DAP. (B) amounts of C derived from 13C-labeled CO2 in each tissue of soybean plants on 24 DAP supplied for 1 hour at 23 DAP. From Yamashita et al. [23].
Changes in the free amino acid concentrations in nodules, roots, stems, and leaves were shown in Figure 13. The nitrate treatment significantly increased the concentration of the amino acids, especially Asp, Asn, and Glu in the nodules. The application of ammonia, urea, or glutamine also increased the concentrations of Asp and Asn in nodules compared with control plants although the increases were not higher than nitrate treatment. On the other hand, the amino acid concentrations in the roots show that ammonium treatment remarkably increased the Asn and Asp concentrations, the urea and glutamine treatments also increased the Asn concentration in the roots, but the increase in Asn in the roots treated with nitrate was relatively low. The increase in the Asn and Asp concentrations was the highest in the stems of plants supplied with urea, followed by glutamine, ammonium, and nitrate treatments. The increase in Asn and Asp was observed from nitrate, ammonium, urea, and glutamine treatments.
Figure 13.
Free amino acid concentrations in each tissue of soybean plants on 24 DAP supplied with various N compounds from 21 to 24 DAP. From Yamashita et al. [23].
Figure 14A shows the effects of nitrogen compounds on total root length on 34 DAP after long-term nitrogen treatment for 2 weeks. The application of nitrate promoted the total root length by over 2-fold compared with the control plants. On the other hand, the application of ammonium inhibited the root length by only a half of the control. The application of urea and glutamine slightly increased the total root length. Similar trends were observed for the root dry weight (Figure 14B). Figure 14C and D show the increase in primary root and lateral roots for the first week of N application from 20 to 27 DAP, and the second week from 27 to 34 DAP. By NO3− application, the growth of the lateral roots was promoted, but the primary root was not. On the other hand, the inhibitory effects of NH4+ were evident both for the primary root and the lateral roots. The promotive effects on the length of the primary root and not on the lateral root length were observed by urea and glutamine applications like nitrate.
Figure 14.
Total root length (A) and the dry weight of roots (B) on 34 DAP after two weeks of the treatments with various forms of N compounds, and the increase in the primary root length (C), and lateral root length (D) for the first week (blue bar) and the second week (red bar). (A) Total root length, (B) Root dry weight, (C) Increase in primary root length, and (D) Increase in lateral root length. From Yamashita et al. [23].
5. The N composition transported in xylem sap of soybean plants cultivated with nitrate, ammonium, urea
Soybean seeds were inoculated with Bradyrhizobium diazoefficiens (strain USDA110), and the seedlings were cultivated in an N-free culture solution until 20 DAP were treated with 5 mM-N of nitrate, ammonium, urea for 3 days until 23 DAP [24]. Control plants were cultivated continuously with N-free solution from 20 to 23 DAP. Another group of soybean plants was not inoculated, and seedlings were cultivated with 5 mM NO3− from 5 to 23 DAP. The xylem sap was collected for 1 h from the cut basal part of the stem on 23 DAP. Figure 15 shows the concentration of N compounds in xylem sap of soybean plants treated with 3 days of nitrate, ammonium, or urea. Non-nodulated plants were cultivated with NO3− due to the lack of nodules.
Figure 15.
Nitrogen concentrations of N compounds in xylem sap of nodulated soybean plants treated with control (N-free), nitrate, ammonium, urea, and non-nodulated plants with nitrate. From Ono et al. [24].
The concentration of ureides (sum of allantoin and allantoic acid) was the highest in control plants depending on nitrogen fixation, followed by ammonium, and urea treatments. The concentration of ureides was very low in nodulated plants treated with nitrate. A small amount of ureides was present in non-nodulated plants. This result is in accordance with the effect of nitrogen compounds on nitrogen fixation activity because most of the ureides in xylem sap originated from fixed nitrogen in nodules, although a small amount is produced in the roots. Nitrate was detected only in the xylem sap of soybean treated with nitrate, and the concentration of nitrate accounted for about 50% of total N in xylem sap either in nodulated or non-nodulated plants supplied with NO3−. The asparagine concentration was the lowest in control plants totally depended on nitrogen fixation, and it was higher in ammonium and urea treatments. The concentration of glutamine was also higher in ammonium and urea treatments, but very low in nitrate treatment. It is interesting that urea is always present in xylem sap and it was higher in control, ammonium, and urea treatments.
The concentrations of ureides and urea or arginine and urea in xylem sap were plotted in Figure 16. The concentration of urea was positively correlated with ureides concentration (Figure 16A), but the correlation was not observed between urea and arginine in xylem sap (Figure 16B) which is the alternative precursor of urea production [25]. Appreciable amounts of urea were present in all the organs for all treatments, and the positive correlations between urea and ureides were observed in the nodules, roots, stems, and leaves. This may indicate that some urea originated from ureides in soybean plants, especially in the roots [24].
Figure 16.
Correlations between the concentrations of ureides and urea (A), and arginine and urea (B) in the soybean xylem sap. (A) Ureide vs. Urea (B) Arginine vs. Urea. From Ono et al. [24].
The ureides, allantoin, and allantoate, are universal metabolites in all organisms including plants, animals, and microorganisms generated by the degradation of futile purines. Soybean plants transport the fixed nitrogen in the nodules mainly in the form of ureides (ca. 80–90% of total N) supplemented with amides and amino acids [26, 27]. On the other hand, nitrate and asparagine are the principal forms of N transport in the xylem sap of the non-nodulated soybean plants [26]. A small percentage of N about 10% was transported in the form of ureides from the non-nodulated roots, which means some ureides can be synthesized in the roots as well as nodules. The concentrations of ureides, nitrate, and amide N transported through xylem sap could be used to evaluate the percentage dependence of N derived from nitrogen fixation [27].
Figure 17 shows a model of ureide synthesis in the nodules and ureide degradation in soybean. The fixed ammonia from N2 in the bacteroid, a symbiotic state of rhizobia, is rapidly excreted to the cytosol of the infected cells, then the ammonium is assimilated by glutamine synthetase (GS)/glutamate synthase (GOGAT) pathway to glutamine [28, 29, 30, 31]. De novo synthesis of purine occurs in the infected cells, and urate is transported to the adjacent uninfected cells and hydrolyzed to allantoin. Some allantoin is further decomposed to allantoate in nodules, then allantoate and allantoin are transported through the xylem. There are two purine degradation pathways in microorganisms, allanotate amidinohydrolase (Pathway A in Figure 17) and allantoate amidohydrolase (Pathway B in Figure 17). In pathway A, allantoate is hydrolyzed and produces two molecules of urea and one molecule of glyoxylate. On the other hand, in pathway B-left no urea is released but 4 ammonium are sequentially released with one molecule of glyoxylate. Studies of ureide degradation in soybean have been done in the leaves, the sink organ of ureides. Shelp and Ireland [32] reported that allantoate degradation is via pathway A, however, Winkler et al. [33, 34] reported that both the leaf extracts and intact leaves of soybean directly liberate ammonium without releasing urea (Pathway B-left). Werner et al. suggested that allantoate degradation intermediates, ureidoglycine and uredoglycolate are non-enzymatically decayed and release urea and glyoxylate (Pathway B-right). In our results relatively high concentrations of urea were presented in xylem sap and all the parts of soybean, and the concentration was correlated with ureide concentration, suggesting that some part of urea may be derived from ureide degradation, especially in the roots [24].
Figure 17.
A model of ureide synthesis in the nodules and ureide degradation in soybean. GS: glutamine synthetase; GOGAT: glutamate synthase; XDH: xanthine dehydrogenase; Xan: xanthine; HIU: hydroxyisourate; OHCU: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline; UGlyAH: ureidoglycine aminohydrolase. From Ono et al. [24].
6. Conclusion
Rapid and reversible repression of nodule growth and nitrogen fixation activity of nodulated soybean were observed when nitrate was supplied in the culture solution. This may be caused by the decrease in the photo-assimilate partitioning to the nodules and not by the transport of N compounds from applied N in the solution. Transcriptome and metabolome analysis supported the above hypothesis. Conversely, the C and N metabolism in the roots was promoted by the application of nitrate. A similar rapid and reversible repression of nodule growth and nitrogen fixation activity was also observed when ammonium, urea, or glutamine was supplied as same as nitrate, however, the inhibitory effect was stronger in nitrate compared with ammonium, urea, or glutamine. Urea was detected in xylem sap and all parts of soybean, and some of the urea originated from ureide degradation.
The plant shoots and roots exchange C and N through the xylem and phloem transport systems [35]. The C and N metabolism is regulated by complex mechanisms to optimize plant organ development and growth. So, understanding the CN metabolism can be related to the agricultural crop production, and maintenance of the agroecosystem.
Acknowledgments
This research was partially supported by the Grants-in-Aid for Scientific Research (No. 18380049, No. 26292036) from Japanese Society for the Promotion of Science.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"soybean, nitrogen fixation, nodules, roots, nitrate, ammonium, urea, ureides",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/82164.pdf",chapterXML:"https://mts.intechopen.com/source/xml/82164.xml",downloadPdfUrl:"/chapter/pdf-download/82164",previewPdfUrl:"/chapter/pdf-preview/82164",totalDownloads:9,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 7th 2021",dateReviewed:"May 10th 2022",datePrePublished:"June 9th 2022",datePublished:null,dateFinished:"June 9th 2022",readingETA:"0",abstract:"Soybean plants require a large amount of nitrogen either from nitrogen fixation in nodules or nitrogen absorption from roots. It is known that nitrate, a major inorganic nitrogen compound in upland soils, represses nodule growth and nitrogen fixation. Rapid and reversible inhibition of nodule growth and nitrogen fixation activity was found in the hydroponically cultivated soybeans after changing the nutrient solution with or without nitrate. Isotope tracer analysis revealed that the major cause of this inhibition depended on the changes in the partitioning of photo-assimilate between nodules and roots and was not directly related to the transported N compounds. Transcriptome and metabolome analyses supported that nitrate strongly promotes nitrogen and carbon metabolism in the roots but represses them in the nodules. The application of ammonium, glutamine, or urea also inhibited the nodule growth and nitrogen fixation like nitrate, although the inhibition was lower than that of nitrate. The degree of inhibition was related to the decrease in carbon isotope partitioning into the nodules, rather than the import of nitrogen isotope to nodules. Urea was detected in xylem sap and all parts of soybean, and some urea might be originated from ureide degradation.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/82164",risUrl:"/chapter/ris/82164",signatures:"Takuji Ohyama, Sayuri Tanabata, Norikuni Ohtake, Takashi Sato, Kuni Sueyoshi, Yoshihiko Takahashi, Shinji Ishikawa, Yuki Ono, Natsumi Yamashita and Akinori Saito",book:{id:"11364",type:"book",title:"Soybean - Recent Advances in Research and Applications",subtitle:null,fullTitle:"Soybean - Recent Advances in Research and Applications",slug:null,publishedDate:null,bookSignature:"Prof. Takuji Ohyama, Dr. Yoshihiko Takahashi, Dr. Norikuni Ohtake, Dr. Takashi Sato and Dr. Sayuri Tanabata",coverURL:"https://cdn.intechopen.com/books/images_new/11364.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-700-7",printIsbn:"978-1-80355-699-4",pdfIsbn:"978-1-80355-701-4",isAvailableForWebshopOrdering:!0,editors:[{id:"30061",title:"Prof.",name:"Takuji",middleName:null,surname:"Ohyama",slug:"takuji-ohyama",fullName:"Takuji Ohyama"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Characteristics of nitrogen assimilation in soybean",level:"2"},{id:"sec_2_2",title:"1.2 Nitrogen inhibition on the growth and nitrogen fixation activity of soybean nodules",level:"2"},{id:"sec_4",title:"2. Short-term effect of nitrate supply on nodule and root growth of soybean",level:"1"},{id:"sec_5",title:"3. Transcriptome and metabolome analyses of nitrate inhibition",level:"1"},{id:"sec_6",title:"4. Effects of nitrate, ammonium, urea, and glutamine on nodule growth and nitrogen fixation activity",level:"1"},{id:"sec_7",title:"5. The N composition transported in xylem sap of soybean plants cultivated with nitrate, ammonium, urea",level:"1"},{id:"sec_8",title:"6. Conclusion",level:"1"},{id:"sec_9",title:"Acknowledgments",level:"1"},{id:"sec_12",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'FAOSTAT. Available from: https://www.fao.org/faostat/en/#data'},{id:"B2",body:'Ohyama T. The role of legume-rhizobium symbiosis in sustainable agriculture. In: Sulieman S, Tran LP, editors. Legume Nitrogen Fixation in Soils with Low Phosphorus Availability. Berlin: Springer; 2017. pp. 1-20. DOI: 10.1007/978-3-319-55729-8_1'},{id:"B3",body:'Ohyama T. Nutrition of soybean seeds. In: Ohyama et al., editors. Traditional and Modern Japanese Soy Foods-Manufacturing, Nutrition and Cuisine of a Variety of Soy Foods for Health and Joy of Taste. New York: NOVA Publishers; 2013. pp. 1-10'},{id:"B4",body:'Ohyama T et al. Soybean seed production and nitrogen nutrition. In: Board JE, editor. A Comprehensive Survey of International Soybean Research-Genetics, Physiology, Agronomy and Nitrogen Relationships. London: InTech; 2013. pp. 115-157'},{id:"B5",body:'Ohyama T et al. Role of nitrogen on growth and seed yield of soybean and a new fertilization technique to promote nitrogen fixation and seed yield. In: Kasai M, editor. Soybean, The Basis of Yield, Biomass and Productivity. London: InTech; 2017. pp. 153-185'},{id:"B6",body:'Sato T, Onoma N, Fujikake H, Ohtake N, Sueyoshi K, Ohyama T. Changes in four leghemoglobin components in nodules of hypernodulating soybean (Glycine max [L] Merr.) mutant and its parent in the early nodule developmental stage. Plant and Soil. 2001;237:129-135'},{id:"B7",body:'Harper JE. Soil and symbiotic nitrogen requirements for optimum soybean production. Crop Science. 1974;14(2):255'},{id:"B8",body:'Rabie RK, Kumazawa K. Effect of nitrate application and shade treatment on the nitrogen fixation and yield of soybean plant. Soil Science & Plant Nutrition. 1979;25(4):467'},{id:"B9",body:'Fred EB, Graul EJ. The effect of soluble nitrogenous salts on nodule formation. Journal of American Society of Agronomy. 1916;8(5):316-328'},{id:"B10",body:'Streeter J. Inhibition of legume nodule formation and N2 fixation by nitrate. CRC Critical Reviews in Plant Sciences. 1988;7(1):1-23'},{id:"B11",body:'Ohyama T et al. Effect of nitrate on nodulation and nitrogen fixation of soybean. In: El-Shemy HA, editor. Soybean, Physiology and Biochemistry. London: InTech; 2011. pp. 333-364'},{id:"B12",body:'Fujikake H, Yashima H, Sato T, Ohtake N, Sueyoshi K, Ohyama T. Rapid and reversible nitrate inhibition of nodule growth and N2 fixation activity in soybean (Glycine max (L.) Merr.). Soil Science & Plant Nutrition. 2002;48(2):211-217'},{id:"B13",body:'Fujikake H, Yamazaki A, Ohtake N, et al. Quick and reversible inhibition of soybean root nodule growth by nitrate involves a decrease in sucrose supply to nodules. Journal of Experimental Botany. 2003;54(386):1379-1388'},{id:"B14",body:'Imsande J. Inhibition of nodule development in soybean by nitrate or reduced nitrogen. Journal of Experimental Botany. 1986;37(3):348-355'},{id:"B15",body:'Tanaka A, Fujita K, Terasawa H. Growth and dinitrogen fixation of soybean root system affected by partial exposure to nitrate. Soil Science & Plant Nutrition. 1985;31(4):637-645'},{id:"B16",body:'Yashima H et al. Long-term effect of nitrate application from lower part of roots on nodulation and N2 fixation in upper part of roots of soybean (Glycine max (L.) Merr.) in two-layered pot experiment. Soil Science & Plant Nutrition. 2005;51(7):981-990'},{id:"B17",body:'Vigue JT, Harper JE, Hageman RH, Peters DB. Nodulation of soybeans grown hydroponically on urea. Crop Science. 1977;17(1):169-172'},{id:"B18",body:'Ohyama T, Nicholas JC, Harper JE. Assimilation of 15N2 and 15NO3− by partially nitrate tolerant nodulation mutants of soybean. Journal of Experimental Botany. 1993;44(269):1739-1747'},{id:"B19",body:'Saito A et al. Effect of nitrate on nodule and root growth of soybean (Glycine max (L.) Merr.). International Journal of Molecular Sciences. 2014:4464-4480. DOI: 10.3390/ijms15034464'},{id:"B20",body:'Available from: https://www.google.com/search?client=firefox-b-d&q=NODAME'},{id:"B21",body:'Tanabata S, Tanabata T, Saito A, et al. Computational image analysis method for measuring size of nodule growth in soybean. Japanese Society of Soil Science and Plant Nutrition. 2014;85(1):43-47. (in Japanese)'},{id:"B22",body:'Ishikawa S, Ono Y, Ohtake N, Sueyoshi K, Tanabata S, Ohyama T. Transcriptome and metabolome analyses reveal that nitrate strongly promotes nitrogen and carbon metabolism in soybean roots, but tends to repress it in nodules. Plants. 2018;7(32). DOI: 10.3390/plants7020032'},{id:"B23",body:'Yamashita N, Tanabata S, Ohtake N, Sueyoshi K, Sato T, Highchi K, et al. Effects of different chemical forms of nitrogen on the quick and reversible inhibition of soybean nodule growth and nitrogen fixation activity. Frontiers in Plant Science. 2019;10(131). DOI: 10.3389/fpls.2019.00131'},{id:"B24",body:'Ono Y, Fukasawa M, Sueyoshi K, Ohtake N, Sato T, Tanabata S, et al. Application of nitrate, ammonium, or urea changes the concentrations of ureides, urea, amino acids and other metabolites in Xylem Sap and in the organs of soybean plants (Glycine max (L.) Merr.). International Journal of Molecular Sciences. 2021;22(4593):4573. DOI: 10.3390/ijms22094573'},{id:"B25",body:'Blume C, Ost J, Mühlenbruch M, Peterhänsel C, Laxa M. Low CO2 indices urea cycle intermediate accumulation in Arabidopsis thaliana. PLoS One. 2019;14(1):e0210342'},{id:"B26",body:'Takahashi Y, Chinushi T, Nagumo Y, Nakano T, Ohyama T. Relative concentration of ureides-N in root-bleeding sap of nodulated and non-nodulated soybean isoline. Japanese Society of Soil Science and Plant Nutrition. 1991;62(4):431-433'},{id:"B27",body:'Takahashi Y, Chinushi T, Ohyama T. Quantitative estimation of N2 fixation and N absorption rate in field grown soybean plants by relative ureide method. Bullut in Faculty of Agriculture Niigata University. 1993;45:91-105'},{id:"B28",body:'Ohyama T, Kumazawa K. Incorporation of 15N into various nitrogenous compounds in intact soybean nodules after exposure to 15N2 gas. Soil Science & Plant Nutrition. 1978;24(4):525-533'},{id:"B29",body:'Ohyama T, Kumazawa K. Assimilation and transport of nitrogenenous compounds originated from 15N2 fixation and 15NO3 absorption. Soil Science & Plant Nutrition. 1979;25(1):9-19'},{id:"B30",body:'Ohyama T, Kumazawa K. Nitrogen assimilation in soybean nodules. I. The role of GS/GOGAT system in the assimilation of ammonia produced by N2 fixation. Soil Science & Plant Nutrition. 1980;26(1):109-115'},{id:"B31",body:'Ohyama T, Kumazawa K. Nitrogen assimilation in soybean nodules. II. 15N2 assimilation in bacteroid and cytosol fractions of soybean nodules. Soil Science & Plant Nutrition. 1980;26(2):205-213'},{id:"B32",body:'Shelp BJ, Ireland RJ. Ureide metabolism in leaves of nitrogen-fixing soybean plants. Plant Physiology. 1985;77(3):779-783. DOI: 10.1104/pp.77.3.779'},{id:"B33",body:'Winkler RG, Polacco JC, Blevins DG, Randall DD. Enzymatic degradation of allantoate in developing soybeans. Plant Physiology. 1985;79(3):787-793. DOI: 10.1104/pp.79.3.787'},{id:"B34",body:'Winkler RG, Blevins DG, Polacco JC, Randall DD. Ureide catabolism of soybeans. II. Pathway of catabolism in intact leaf tissue. Plant Physiology. 1987;83(3):585-591. DOI: 10.1104/pp.83.3.585'},{id:"B35",body:'Marouane B, Mitsui T, Sueyoshi K, Ohyama T. Recent advances in carbon and nitrogen metabolismin C3 plants. International Journal of Molecular Sciences. 2021;22(1):318. DOI: 10.3390/ijms22010318'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Takuji Ohyama",address:"to206474@nodai.ac.jp",affiliation:'
Department of Agricultural Chemistry, Tokyo University of Agriculture, Japan
Graduate School of Science and Technology, Niigata University, Japan
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She received a MA from Warsaw University and a MD from Nicolaus Copernicus University. She works with patients (both children and adults) with neurological conditions, especially those who have cognitive deficits that result from the genetic or other somatic diseases (for example neurofibromatosis), who have developed progressive dementing disorders and who struggle with developmental neurobehavioral disorders. Beginning form the 2000 she is consultant psychologist in the Transplantology and Surgery Department in the University Hospital of Collegium Medicum in Bydgoszcz (Poland). Dr. Trzcińska is also a certified psychotherapist. She completed her postgraduate diploma in cognitive – behavioural therapy in Cognitive Behavioural Therapy Cenrtre in Warsaw in cooperation with the Oxford Cognitive Therapy Centre. 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The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
\\n\\n
2005
\\n\\n
\\n\\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\\n
\\n\\n
2006
\\n\\n
\\n\\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\\n
\\n\\n
2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\\n
\\n\\n
2013
\\n\\n
\\n\\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\\n
\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
\\n\\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\\n
\\n\\n
2015
\\n\\n
\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\\n\\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\\n\\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
\\n\\n
\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\\n
\\n\\n
2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
\n\n
\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
\n\n
2016
\n\n
\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
\n\n
2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\n\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. 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Garg"},{id:"169846",title:"Dr.",name:"Harsimran",middleName:null,surname:"Gill",slug:"harsimran-gill",fullName:"Harsimran Gill"}]},{id:"43317",doi:"10.5772/54833",title:"Extreme Temperature Responses, Oxidative Stress and Antioxidant Defense in Plants",slug:"extreme-temperature-responses-oxidative-stress-and-antioxidant-defense-in-plants",totalDownloads:11583,totalCrossrefCites:70,totalDimensionsCites:153,abstract:null,book:{id:"3226",slug:"abiotic-stress-plant-responses-and-applications-in-agriculture",title:"Abiotic Stress",fullTitle:"Abiotic Stress - Plant Responses and Applications in Agriculture"},signatures:"Mirza Hasanuzzaman, Kamrun Nahar and Masayuki Fujita",authors:[{id:"47687",title:"Prof.",name:"Masayuki",middleName:null,surname:"Fujita",slug:"masayuki-fujita",fullName:"Masayuki Fujita"},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman"},{id:"166818",title:"MSc.",name:"Kamrun",middleName:null,surname:"Nahar",slug:"kamrun-nahar",fullName:"Kamrun Nahar"}]},{id:"21989",doi:"10.5772/17184",title:"Bacillus-Based Biological Control of Plant Diseases",slug:"bacillus-based-biological-control-of-plant-diseases",totalDownloads:17384,totalCrossrefCites:64,totalDimensionsCites:150,abstract:null,book:{id:"432",slug:"pesticides-in-the-modern-world-pesticides-use-and-management",title:"Pesticides in the Modern World",fullTitle:"Pesticides in the Modern World - Pesticides Use and Management"},signatures:"Hélène Cawoy, Wagner Bettiol, Patrick Fickers and Marc Ongena",authors:[{id:"27515",title:"Prof.",name:"Patrick",middleName:null,surname:"Fickers",slug:"patrick-fickers",fullName:"Patrick Fickers"},{id:"40395",title:"Dr.",name:"Marc",middleName:null,surname:"Ongena",slug:"marc-ongena",fullName:"Marc Ongena"},{id:"108031",title:"Ms.",name:"Hélène",middleName:null,surname:"Cawoy",slug:"helene-cawoy",fullName:"Hélène Cawoy"},{id:"108032",title:"Dr.",name:"Wagner",middleName:null,surname:"Bettiol",slug:"wagner-bettiol",fullName:"Wagner Bettiol"}]},{id:"40178",doi:"10.5772/52583",title:"Molecular Markers and Marker-Assisted Breeding in Plants",slug:"molecular-markers-and-marker-assisted-breeding-in-plants",totalDownloads:23053,totalCrossrefCites:82,totalDimensionsCites:148,abstract:null,book:{id:"3060",slug:"plant-breeding-from-laboratories-to-fields",title:"Plant Breeding from Laboratories to Fields",fullTitle:"Plant Breeding from Laboratories to Fields"},signatures:"Guo-Liang Jiang",authors:[{id:"158810",title:"Dr.",name:"Guo-Liang",middleName:null,surname:"Jiang",slug:"guo-liang-jiang",fullName:"Guo-Liang Jiang"}]}],mostDownloadedChaptersLast30Days:[{id:"64570",title:"Banana Pseudo-Stem Fiber: Preparation, Characteristics, and Applications",slug:"banana-pseudo-stem-fiber-preparation-characteristics-and-applications",totalDownloads:9428,totalCrossrefCites:15,totalDimensionsCites:18,abstract:"Banana is one of the most well-known and useful plants in the world. Almost all the parts of this plant, that are, fruit, leaves, flower bud, trunk, and pseudo-stem, can be utilized. This chapter deals with the fiber extracted from the pseudo-stem of the banana plant. It discusses the production of banana pseudo-stem fiber, which includes plantation and harvesting; extraction of banana pseudo-stem fiber; retting; and degumming of the fiber. It also deals with the characteristics of the banana pseudo-stem fiber, such as morphological, physical and mechanical, durability, degradability, thermal, chemical, and antibacterial properties. Several potential applications of this fiber are also mentioned, such as the use of this fiber to fabricate rope, place mats, paper cardboard, string thread, tea bags, high-quality textile materials, absorbent, polymer/fiber composites, etc.",book:{id:"7544",slug:"banana-nutrition-function-and-processing-kinetics",title:"Banana Nutrition",fullTitle:"Banana Nutrition - Function and Processing Kinetics"},signatures:"Asmanto Subagyo and Achmad Chafidz",authors:[{id:"257742",title:"M.Sc.",name:"Achmad",middleName:null,surname:"Chafidz",slug:"achmad-chafidz",fullName:"Achmad Chafidz"},{id:"268400",title:"Mr.",name:"Asmanto",middleName:null,surname:"Subagyo",slug:"asmanto-subagyo",fullName:"Asmanto Subagyo"}]},{id:"40180",title:"Plant Tissue Culture: Current Status and Opportunities",slug:"plant-tissue-culture-current-status-and-opportunities",totalDownloads:66452,totalCrossrefCites:43,totalDimensionsCites:89,abstract:null,book:{id:"3568",slug:"recent-advances-in-plant-in-vitro-culture",title:"Recent Advances in Plant in vitro Culture",fullTitle:"Recent Advances in Plant in vitro Culture"},signatures:"Altaf Hussain, Iqbal Ahmed Qarshi, Hummera Nazir and Ikram Ullah",authors:[{id:"147617",title:"Dr.",name:"Altaf",middleName:null,surname:"Hussain",slug:"altaf-hussain",fullName:"Altaf Hussain"}]},{id:"66996",title:"Ethiopian Common Medicinal Plants: Their Parts and Uses in Traditional Medicine - Ecology and Quality Control",slug:"ethiopian-common-medicinal-plants-their-parts-and-uses-in-traditional-medicine-ecology-and-quality-c",totalDownloads:4059,totalCrossrefCites:6,totalDimensionsCites:10,abstract:"The main purpose of this review is to document medicinal plants used for traditional treatments with their parts, use, ecology, and quality control. Accordingly, 80 medicinal plant species were reviewed; leaves and roots are the main parts of the plants used for preparation of traditional medicines. The local practitioners provided various traditional medications to their patients’ diseases such as stomachaches, asthma, dysentery, malaria, evil eyes, cancer, skin diseases, and headaches. The uses of medicinal plants for human and animal treatments are practiced from time immemorial. Stream/riverbanks, cultivated lands, disturbed sites, bushlands, forested areas and their margins, woodlands, grasslands, and home gardens are major habitats of medicinal plants. Generally, medicinal plants used for traditional medicine play a significant role in the healthcare of the majority of the people in Ethiopia. The major threats to medicinal plants are habitat destruction, urbanization, agricultural expansion, investment, road construction, and deforestation. Because of these, medicinal plants are being declined and lost with their habitats. Community- and research-based conservation mechanisms could be an appropriate approach for mitigating the problems pertinent to the loss of medicinal plants and their habitats and for documenting medicinal plants. Chromatography; electrophoretic, macroscopic, and microscopic techniques; and pharmaceutical practice are mainly used for quality control of herbal medicines.",book:{id:"8502",slug:"plant-science-structure-anatomy-and-physiology-in-plants-cultured-in-vivo-and-in-vitro",title:"Plant Science",fullTitle:"Plant Science - Structure, Anatomy and Physiology in Plants Cultured in Vivo and in Vitro"},signatures:"Admasu Moges and Yohannes Moges",authors:[{id:"249746",title:"Ph.D.",name:"Admasu",middleName:null,surname:"Moges",slug:"admasu-moges",fullName:"Admasu Moges"},{id:"297761",title:"MSc.",name:"Yohannes",middleName:null,surname:"Moges",slug:"yohannes-moges",fullName:"Yohannes Moges"}]},{id:"70658",title:"Factors Affecting Yield of Crops",slug:"factors-affecting-yield-of-crops",totalDownloads:4044,totalCrossrefCites:25,totalDimensionsCites:40,abstract:"A good understanding of dynamics involved in food production is critical for the improvement of food security. It has been demonstrated that an increase in crop yields significantly reduces poverty. Yield, the mass of harvest crop product in a specific area, is influenced by several factors. These factors are grouped in three basic categories known as technological (agricultural practices, managerial decision, etc.), biological (diseases, insects, pests, weeds) and environmental (climatic condition, soil fertility, topography, water quality, etc.). These factors account for yield differences from one region to another worldwide. The current chapter will discuss each of these three basic factors as well as providing some recommendations for overcoming them. In addition, it will provide the importance of climate-smart agriculture in the increase of crop yields while facilitating the achievement of crop production in safe environment. This goes in line with the second goal of 2030 Agenda for Sustainable Development of United Nations in transforming our world formulated as end hunger, achieve food security, improve nutrition and promote sustainable agriculture.",book:{id:"8153",slug:"agronomy-climate-change-food-security",title:"Agronomy",fullTitle:"Agronomy - Climate Change & Food Security"},signatures:"Tandzi Ngoune Liliane and Mutengwa Shelton Charles",authors:[{id:"313819",title:"Dr.",name:"Liliane",middleName:null,surname:"Tandzi",slug:"liliane-tandzi",fullName:"Liliane Tandzi"},{id:"314316",title:"Prof.",name:"Charles Shelton",middleName:null,surname:"Mutengwa",slug:"charles-shelton-mutengwa",fullName:"Charles Shelton Mutengwa"}]},{id:"59402",title:"Robotic Harvesting of Fruiting Vegetables: A Simulation Approach in V-REP, ROS and MATLAB",slug:"robotic-harvesting-of-fruiting-vegetables-a-simulation-approach-in-v-rep-ros-and-matlab",totalDownloads:2797,totalCrossrefCites:7,totalDimensionsCites:8,abstract:"In modern agriculture, there is a high demand to move from tedious manual harvesting to a continuously automated operation. This chapter reports on designing a simulation and control platform in V-REP, ROS, and MATLAB for experimenting with sensors and manipulators in robotic harvesting of sweet pepper. The objective was to provide a completely simulated environment for improvement of visual servoing task through easy testing and debugging of control algorithms with zero damage risk to the real robot and to the actual equipment. A simulated workspace, including an exact replica of different robot manipulators, sensing mechanisms, and sweet pepper plant, and fruit system was created in V-REP. Image moment method visual servoing with eye-in-hand configuration was implemented in MATLAB, and was tested on four robotic platforms including Fanuc LR Mate 200iD, NOVABOT, multiple linear actuators, and multiple SCARA arms. Data from simulation experiments were used as inputs of the control algorithm in MATLAB, whose outputs were sent back to the simulated workspace and to the actual robots. ROS was used for exchanging data between the simulated environment and the real workspace via its publish-and-subscribe architecture. Results provided a framework for experimenting with different sensing and acting scenarios, and verified the performance functionality of the simulator.",book:{id:"6265",slug:"automation-in-agriculture-securing-food-supplies-for-future-generations",title:"Automation in Agriculture",fullTitle:"Automation in Agriculture - Securing Food Supplies for Future Generations"},signatures:"Redmond R. Shamshiri, Ibrahim A. Hameed, Manoj Karkee and\nCornelia Weltzien",authors:[{id:"182449",title:"Prof.",name:"Ibrahim",middleName:"A.",surname:"Hameed",slug:"ibrahim-hameed",fullName:"Ibrahim Hameed"},{id:"203413",title:"Dr.",name:"Redmond R.",middleName:null,surname:"Shamshiri",slug:"redmond-r.-shamshiri",fullName:"Redmond R. Shamshiri"},{id:"241193",title:"Dr.",name:"Manoj",middleName:null,surname:"Karkee",slug:"manoj-karkee",fullName:"Manoj Karkee"},{id:"241194",title:"Dr.",name:"Cornelia",middleName:null,surname:"Weltzien",slug:"cornelia-weltzien",fullName:"Cornelia Weltzien"}]}],onlineFirstChaptersFilter:{topicId:"5",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82508",title:"Introductory Chapter: Global Cotton Research Development Trends for the Past Five Years - Key Directions",slug:"introductory-chapter-global-cotton-research-development-trends-for-the-past-five-years-key-direction",totalDownloads:0,totalDimensionsCites:0,doi:"10.5772/intechopen.105748",abstract:null,book:{id:"11362",title:"Cotton",coverURL:"https://cdn.intechopen.com/books/images_new/11362.jpg"},signatures:"Ibrokhim Y. Abdurakhmonov"},{id:"82512",title:"Antimicrobial Residues in Meat and Meat Products",slug:"antimicrobial-residues-in-meat-and-meat-products",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.105784",abstract:"The presence of antimicrobial residues (AMRs) in meat is considered a serious threat to public health in the twenty-first century. This work aims at addressing the problem of AMRs in meat regarding their sources, negative effects, detection tests, and prevention and control practices. The health risks associated with such residues include direct toxicity, drug allergy, hypersensitive reactions, and the development of antibiotic-resistant bacteria. Moreover, disturbance of gut microbiota and bone marrow disorders are also direct consequences of continuous exposure to small quantities of antimicrobial residues (AMRs). Due to long-term exposure to antibiotic residues during gestation, various congenital anomalies were also seen in newborn children. Carcinogenic impacts and mutagenic effects are other negative impacts of antibiotic residues on the food. Different practices are known to introduce AMRs into meat and meat products, such as misuse of chemotherapeutic medications, violating withdrawal periods, even with the proper administration of anti-infective agents, and usage of antibiotics as growth promoters and feed additives. The prevention of this problem requires multi-sector cooperation to restrict the improper use of antimicrobial drugs, standardize the rationale usage, and development of alternative chemicals or biologics for the purposes of preservation of meat products and as growth promoters for food-producing animals.",book:{id:"11638",title:"Meat Science and Nutrition - Recent Advances and Innovative Processing Technologies",coverURL:"https://cdn.intechopen.com/books/images_new/11638.jpg"},signatures:"Dhary Alewy Almashhadany, Hero I. Mohammed, Thaera Abdulwahid M. Muslat, Rzgar F. Rashid, Rawaz R. Hassan and Abdullah O. Hassan"},{id:"81769",title:"Biological Control of Agricultural Insect Pests",slug:"biological-control-of-agricultural-insect-pests",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.104464",abstract:"Pests are highly responsible for heavy crop losses and reduced food supplies, poorer quality of agricultural products, economic hardship for growers and processor. Generally, chemical control methods are practiced for their control which is neither always economical nor effective and may have associated unwanted health, safety and environmental risks. However, to meet the challenge of feeding to the ever increasing human population, an efficient, economical and environment friendly disease control methods are requisites. In this regard, biological control may be an effective means of reducing or mitigating the pests and pest effects through the use of natural enemies. Biological control is an environmentally sound which involves the use of beneficial microorganism to control plant pathogens and diseases they cause. Therefore, in this chapter we will provide a comprehensive account of this environmental friendly approach for effectively management of plant diseases. This chapter will also accentuate the development of biological control agents for practical applications and the underlying mechanism. The contents in the chapter will be beneficial and advantageous to all those working in academia or industry related to crop protection.",book:{id:"11015",title:"Insecticides",coverURL:"https://cdn.intechopen.com/books/images_new/11015.jpg"},signatures:"Mrinalini Kumari, Atul Srivastava, Shyam Babu Sah and Subhashini Sini"},{id:"82474",title:"Vitamin D Deficiency in Childhood Obesity: Behavioral Factors or Altered Metabolism?",slug:"vitamin-d-deficiency-in-childhood-obesity-behavioral-factors-or-altered-metabolism",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105819",abstract:"Obesity childhood is related to vitamin D deficiency, but the mechanisms for this association still remain questionable. We hypothesized that behavioral factors would be decisive in reducing the body content of vitamin D in patients with obesity. A cross-sectional clinical and analytical study (calcium, phosphorus, calcidiol, and parathyroid hormone) was carried out in a group of 377 patients with obesity (BMI-DS >2.0), 348 patients with severe obesity (BMI-DS >3.0), and 411 healthy children. The place of residence was categorized as urban or rural. Vitamin D status was defined according to the US Endocrine Society criteria. The prevalence of vitamin D deficiency was significantly higher (p < 0.001) in severe obesity (48.6%) and obesity groups (36.1%) than in the control group (12.5%). Vitamin D deficiency was more frequent in severe obesity and obesity groups living in urban areas than in those living in rural areas (not in the control group). The patients with obesity living in urban residence did not present significant seasonal variations in vitamin D deficiency throughout the year in contrast to those patients with obesity living in rural residence. These findings suggest that the most probable mechanism for vitamin D deficiency in children and adolescents with obesity, rather than altered metabolic, is the behavioral factors (sedentary lifestyle and lack of adequate sunlight exposure).",book:{id:"11639",title:"Vitamin D Deficiency - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11639.jpg"},signatures:"Teodoro Durá-Travé and Fidel Gallinas-Victoriano"},{id:"82475",title:"Pharmacological Efficacy and Mechanism of Vitamin D in the Treatment of “Kidney-Brain” Disorders",slug:"pharmacological-efficacy-and-mechanism-of-vitamin-d-in-the-treatment-of-kidney-brain-disorders",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105820",abstract:"Accumulating evidences have shown that serum 25-hydroxyvitamin D concentrations were inversely correlated with the incidence or severity of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and that vitamin D deficiency might be associated with an increased susceptibility to many of the complications accompanied by COVID-19, such as disorders in kidney and brain. Our previous experimental studies demonstrated that vitamin D and its analogs could protect from kidney diseases, neuroinflammation, and musculoskeletal disorders such as osteoporosis and muscle atrophy, through the suppressive effects on overactivation of the renin-angiotensin system (RAS) in tissues. Moreover, we published a review describing the therapeutic effects of traditional Chinese medicine (TCM) for organ injuries associated with COVID-19 by interfering with RAS. In the TCM principle “Kidney dredges brain,” this chapter will emphasize the potential preventive and therapeutic effects of vitamin D on both renal injuries and central nervous system disorders in COVID-19 patients and further elucidate the pharmacological effects with underlying mechanisms of vitamin D in “Kidney-Brain” disorders.",book:{id:"11639",title:"Vitamin D Deficiency - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11639.jpg"},signatures:"Jia-Li Zhang, Yong-Jun Wang and Yan Zhang"},{id:"82217",title:"Sustainable Management Plans in Fisheries and Genetic Tools: An Overview of the Challenge in Invertebrates’ Fisheries at the Central Area of the Southern Bay of Biscay, Spain",slug:"sustainable-management-plans-in-fisheries-and-genetic-tools-an-overview-of-the-challenge-in-inverteb",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.105353",abstract:"The fishing and aquaculture sectors are an important source of development around the globe. In Asturias (Spain), the diversity and richness of the fishing grounds of the Cantabrian Sea favored the historical settlement of a large number of communities closely linked to the marine environment and fishing resources, forming an integral part of the region’s cultural and natural heritage. However, aquatic ecosystems are facing, nowadays, important threats from anthropogenic activities. To address these problems and avoid their impact on fishing activities, it is essential to know the ecological and genetic status of the species. Despite this, the application of genetic tools is still incipient in many species of commercial interest; however, its use can help to generate data that allow better regulation and fisheries planning. Here, the use of genetic markers and educational strategies in the management of some shellfish species of great commercial and cultural value in Asturias are reviewed. Moving toward sustainable fisheries management is a priority that can only be achieved through R + D + i, educational strategies, and the development and implementation of a regional strategy oriented toward the sustainable management and exploitation.",book:{id:"10748",title:"Fishery",coverURL:"https://cdn.intechopen.com/books/images_new/10748.jpg"},signatures:"Marina Parrondo, Lucía García-Florez, Eduardo Dopico and Yaisel J. Borrell"}],onlineFirstChaptersTotal:354},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"22",title:"Business, Management and Economics",doi:"10.5772/intechopen.100359",issn:"2753-894X",scope:"
\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. Topics will include asset liability management, financial consequences of the financial crisis and covid-19, financial accounting, mergers and acquisitions, management accounting, SMEs, financial markets, corporate finance and governance, managerial technology and innovation, resource management and sustainable development, social entrepreneurship, corporate responsibility, ethics and accountability, microeconomics, labour economics, macroeconomics, public economics, financial economics, econometrics, direct marketing, creative marketing, internet marketing, market planning and forecasting, brand management, market segmentation and targeting and other topics under business and management. This book series will focus on various aspects of business and management whose in-depth understanding is critical for business and company management to function effectively during this uncertain time of financial crisis, Covid-19 pandemic, and military activity in Europe.
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He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. 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\r\n\tThe integration of tissues and organs throughout the mammalian body, as well as the expression, structure, and function of molecular and cellular components, is essential for modern physiology. The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
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He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},onlineFirstChapters:{paginationCount:20,paginationItems:[{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",signatures:"Zuhair S. 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\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
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\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
\r\n\tWater is not only a crucial substance needed for biological life on Earth, but it is also a basic requirement for the existence and development of the human society. Owing to the importance of water to life on Earth, early researchers conducted numerous studies and analyses on the liquid form of water from the perspectives of chemistry, physics, earth science, and biology, and concluded that Earth is a "water polo". Water covers approximately 71% of Earth's surface. However, 97.2% of this water is seawater, 21.5% is icebergs and glaciers, and only 0.65% is freshwater that can be used directly by humans. As a result, the amount of water reserves available for human consumption is limited. The development, utilization, and protection of freshwater resources has become the focus of water science research for the continued improvement of human livelihoods and society.
\r\n
\r\n\tWater exists as solid, liquid, and gas within Earth’s atmosphere, lithosphere, and biosphere. Liquid water is used for a variety of purposes besides drinking, including power generation, ecology, landscaping, and shipping. Because water is involved in various environmental hydrological processes as well as numerous aspects of the economy and human society, the study of various phenomena in the hydrosphere, the laws governing their occurrence and development, the relationship between the hydrosphere and other spheres of Earth, and the relationship between water and social development, are all part of water science. Knowledge systems for water science are improving continuously. Water science has become a specialized field concerned with the identification of its physical, chemical, and biological properties. In addition, it reveals the laws of water distribution, movement, and circulation, and proposes methods and tools for water development, utilization, planning, management, and protection. Currently, the field of water science covers research related to topics such as hydrology, water resources and water environment. It also includes research on water related issues such as safety, engineering, economy, law, culture, information, and education.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",keywords:"Water, Water resources, Freshwater, Hydrological processes, Utilization, Protection"}],annualVolumeBook:{},thematicCollection:[{type:"book",id:"11672",title:"Chemokines Updates",subtitle:null,isOpenForSubmission:!0,hash:"c00855833476a514d37abf7c846e16e9",slug:null,bookSignature:"Prof. Murat Şentürk",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",editedByType:null,submissionDeadline:"May 6th 2022",editors:[{id:"14794",title:"Prof.",name:"Murat",middleName:null,surname:"Şentürk",slug:"murat-senturk",fullName:"Murat Şentürk",profilePictureURL:"https://mts.intechopen.com/storage/users/14794/images/system/14794.jpeg",biography:"Dr. Murat Şentürk obtained a baccalaureate degree in Chemistry in 2002, a master’s degree in Biochemistry in 2006, and a doctorate degree in Biochemistry in 2009 from Atatürk University, Turkey. Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. Dr. Şentürk serves as the editorial board member of several international journals.",institutionString:"Ağrı İbrahim Çeçen University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Ağrı İbrahim Çeçen University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}],selectedSeries:{title:"Environmental Sciences",id:"25"},selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:318,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/74033",hash:"",query:{},params:{id:"74033"},fullPath:"/chapters/74033",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()