",isbn:"978-1-80356-678-8",printIsbn:"978-1-80356-677-1",pdfIsbn:"978-1-80356-679-5",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"6dcb071a2e978694b6b1cb9c20afc1a3",bookSignature:"Prof. Hai-Zhi Song",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11494.jpg",keywords:"Electric Field Effect, Nano-Materials, Electric Field Design, Antenna, Microelectronics, Optoelectronics, Electric Field Stimulation, Brain and Nerve, Electric Field Imaging, Atomic Electric Field, Space Science, Climate",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in the fields of new materials, optoelectronic devices, and quantum information processing, appointed vice director of the Science and Technology Committee of SWITP, author/co-author of more than 170 research papers, and holder of 40 patents.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"196114",title:"Prof.",name:"Hai-Zhi",middleName:null,surname:"Song",slug:"hai-zhi-song",fullName:"Hai-Zhi Song",profilePictureURL:"https://mts.intechopen.com/storage/users/196114/images/system/196114.jpg",biography:"Curriculum Vitae\n\nName: Hai-Zhi Song \nGender: male\nDate of Birth: Oct. 20, 1968\nPlace of Birth: Shanxi, China\nAffiliation and Address: \nSouthwest Institute of Technical Physics\nNo.7, Section 4, Renminnan Road, Chengdu 610041, China\nAnd\nInstitute of Fundamental and Frontier Sciences,\nUniversity of Electronic Science and Technology of China,\nNo. 4, Section 2, Jianshebei Road, Chengdu 610054, China\n\nWork Phone: +86-28-68180751, +86-28-83208728\nMobile Phone: +86-158-28239155\nFax: +86-28-83201896\nE-mail: hzsong1296@163.com, hzsong@uestc.edu.cn\n \nEducation \nSept, 1990 – July, 1995:Peking University, PhD, Thesis “Visible luminescence of porous silicon and its mechanism”, Researches on hydrogen-influenced Schottky diodes and silicon-based light-emitting materials. \nSept, 1986 – July, 1990:Nanjing University, Bachelor of Science, Thesis “Study of refractory metal silicides”, Research on Ohmic contact of semiconductors.\n\nWork Experience \nJuly, 1995 – Sept. 1997: Nanjing University, Nanjing, China, Postdoctoral Researcher, Research on silicon-based light-emitting materials. \nOct, 1997 – Sept. 1998: Catholic University Leuven, Leuven, Belgium, Visiting free Researcher, Research on amorphous semiconductors. \nOct, 1998 – Sept. 2001: Tsukuba University, Tsukuba, Japan, Assistant Professor, Research on semiconductor quantum dots. \nOct, 2001 – March 2012: Fujitsu Lab. Ltd., Atsugi, Japan, Researcher/Senior Researcher, Researches on Semiconductor Quantum Dots for Quantum Information, Semiconductor Optoelectronic Materials and Devices. \nApril, 2012 – March 2014: University of Tokyo, Tokyo, Japan, Senior Researcher, Researches on Quantum Information Processing Devices. \nApril, 2014 – now: Southwest Institute of Technical Physics, Chengdu, China, Professor, Researches on Semiconductor Optoelectronic Materials and Devices. \nJune, 2015 – now: University of Electronic Science and Technology, Chengdu, China, Professor, Researches on Nanoscaled Semiconductors and Quantum Information Processing Devices.\n \nAchievements\nSystematically studied the property of porous silicon materials and verified their mechanism; found green and ultraviolet luminescence, and clarified the multiple luminescence mechanisms of nanocrystalline-silicon embedded in SiO2, which is valuable to silicon-based optoelectronic integration; realized enhanced hole mobility in amorphous silicon, verified the existence of deep trap states in amorphous selenium, providing ways to improve amorphous optoelectronic materials. \nDiscovered lateral coupling between self-assembled quantum dots (QDs) and their tuning effect to 2D electron gas; illustrated and deeply explained the metal-insulator transition in 2D ordered QD arrays, all of which are worth in optoelectronic application of semiconductor QDs. \nDeveloped Sb-free technique to double the InAs/GaAs QD density and suppress the atomic interdiffusion, helped producing 1.3 um QD lasers, which won Japanese national prizes and had been merchandized; developed 1.06 um quantum-well lasers, which have been used to produce pure-green lasers robust against high temperature. \nFound a way to access buried QDs by scanning tunneling microscope; achieved a way to prepare diluted QDs by post-annealing and clarified its mechanisms; invented a technique to control the size and site of QDs by atomic-force microscopy lithography, and an apparatus to detect single electron spin states by optically-detected magnetic resonance; designed a few types of micropillar cavities applicable to realize 1.55 um highly-efficient, even coherent (strongly coupled) InAs/InP QD single photon sources; produced fiber-integrated photon-entangled sources, all of which are very useful to the applications of QDs in quantum information processing. \nDeveloped focal-plane single-photon avalanche detectors, providing central devices for 3D laser detecting and ranging system; explored antimonide middle- and long-wavelength infrared detectors and the surface plasmon enhancement effect in such detectors; advanced the acetone-sensing function of Eu-doped SnO2 nano-belt; found Nickle Phosphide serving as a good catalyst in hydrogen-producing. Realized a series of optoelectronic quantum devices for quantum information processing, such as fiber-integrated photon-pair-entangler, chiplet heralded single photon emitter, fiber quantum memories, quantum number generator, etc.\n\nHonor and Group Memberships \nSelected Scholar of the Recruitment Program of Global Experts, China\nEditorial member of “Laser Technology”\nEditorial member of “Journal of Electronic Science and Technology”\nEditorial member of “Internal J. Mat. Sci. Appl”\nMember of APS (American Physics Society)\nMember of OSA (Optical Society of America)\nPermanent Member of China Physical Science and Technology\nPermanent Member of the Chinese Optical Society\nTechnical committee member of PIERS, organizing a series of “quantum information processing and devices” sessions\nTechnical committee member of ICICM",institutionString:"Southwest University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Southwest University",institutionURL:null,country:{name:"China"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"20",title:"Physics",slug:"physics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453623",firstName:"Silvia",lastName:"Sabo",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/453623/images/20396_n.jpg",email:"silvia@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"8356",title:"Metastable, Spintronics Materials and Mechanics of Deformable Bodies",subtitle:"Recent Progress",isOpenForSubmission:!1,hash:"1550f1986ce9bcc0db87d407a8b47078",slug:"solid-state-physics-metastable-spintronics-materials-and-mechanics-of-deformable-bodies-recent-progress",bookSignature:"Subbarayan Sivasankaran, Pramoda Kumar Nayak and Ezgi Günay",coverURL:"https://cdn.intechopen.com/books/images_new/8356.jpg",editedByType:"Edited by",editors:[{id:"190989",title:"Dr.",name:"Subbarayan",surname:"Sivasankaran",slug:"subbarayan-sivasankaran",fullName:"Subbarayan Sivasankaran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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1. Introduction
Fluctuations in electrical power greatly affect the performance of power generation systems. Changes in electrical power due to variations in demand for electrical power momentarily result in an imbalance of electricity generated by the electric power absorbed. If the power supplied is greater than there will be energy waste. And if the power supplied is smaller then there will be overload which will result in a blackout. This means that the amount of electric power generated must be balanced or not too far from the nominal value of the electrical power requirements at the load center. In fact, the use of electrical energy tends to change at any time. For this reason, it is necessary to predict the use of electric power that is able to maintain a balance between supply and consumption of electric power in the power generation system. Research of electricity load forecasting is very important in the power plant system operation plan [1]. Load forecasting studies are classified into three categories: long-term, medium-term and short-term predictions. Long-term predictions are needed for planning the peak load capacity and system maintenance schedule [2], medium-term predictions are needed for the planning and operation of the power plant system [3], and short-term predictions are needed to control and schedule the generating system [4]. So that load forecasting studies play a role in ensuring the economic value of financing, system reliability, stability and quality of electricity system services.
Fluctuations in electrical power at the load center contain a set of time-based information. The characteristics of the load from the period of use both by household, commercial, industrial and public costs, are needed so that fluctuations can be analyzed. The load characteristics, besides being able to be analyzed also contain a series of load patterns tendencies due to usage. This conduct of using electric loads contains seasonal patterns. Daily use tends to recur on certain days, as well as weekly load patterns. This trend is then analyzed through the load cluster approach to achieve load usage patterns based on seasonal patterns.
The Box-Jenkins time series study approach conducted in this research was able to increase the estimated usage and application of seasonal patterns based on electricity load clusters. The time series prediction model is an accurate choice and continues to grow to this day [5, 6, 7]. Researchers have carried out load forecasting study activities with 2.06 percent MAPE [8]. In research, the parameter estimation pattern was developed again with the least squares method which is better. And then the load cluster modeling is developed to classify the trend based on seasonal patterns.
2. Electrical load characteristics
The main purpose of an electric power distribution system is to distribute electric power from substations or sources to a number of customers or loads. The most important main factor in the distribution system planning is the characteristics of various electrical loads.
The electrical load characteristics are needed so that the system voltage, the thermal effect of loading and the loading pattern can be analyzed properly. The analysis is included in determining the initial projections in the next planning.
The characteristics of the electrical load are very dependent on the type of load it serves. This will be clearly seen from the results of recording the load curve in a time interval. The following are several factors that determine the load characteristics according to the needs of this study [9].
2.1 Load factor
Load factor is the ratio between average load and peak load measured in a certain period. Average load and peak load can be expressed in KiloWatt (KW), KiloVolt-Ampere (KVA) and so on, but the units of both must be the same. Load factor can be calculated for a certain period usually used in units of daily, monthly or yearly.
The peak load referred to in this study is a momentary peak load or average peak load in a certain interval (maximum demand), generally a maximum demand of 15 minutes or 30 minutes is used. In this study, the load data used is 30-minute interval load data.
The definition of the load factor can be written in the following equation:
when you are citing sources, the citations should be set in numbered format. All the references given in the list of references should be cited in the body of the text. Please set citations in square brackets keeping the below points in mind.
The load factor can be known from the load curve. As for the estimation of the magnitude of the burden factor in the future, it can be approached with existing statistical data as was done in this study.
When applied to the power plant, it is formulated into
Load factor=PaveragePpeak×TTE2
If T is in a year, an annual expense factor is obtained. If in 1 month the monthly load factor is obtained, as well as the daily load factor.
2.2 Daily load
Daily load factors vary according to the characteristics of the load area, whether it is a dense residential area, industrial area, trade or a combination of various types of customers.
This daily load factor will also affect the weather conditions and certain days such as holidays and so on.
2.3 Load curve
Load curves illustrate the variation of loading on a substation measured by KW or KVA as a function of time. Measurement time intervals are usually determined based on the use of measurement results, for example intervals of 30 minutes, 60 minutes, 1 day or 1 week.
The load curve shows the demand or load requirements at different time intervals. With the help of this load curve, we can determine the magnitude of the largest load and then the generating capacity can also be determined.
2.4 Peak load
Peak load or maximum demand is defined as the biggest load of needs that occurs during a certain period. Certain periods can be in the form of daily, monthly or annual periods. Furthermore, the peak load must be interpreted as the average load during a certain interval, where the possibility of such load. For example, the daily load of a distribution transformer where the peak load during an interval of 1 hour, ie between 19:00 (point A) and 20:00 (point B). The average value of the A - B curve is its peak requirement.
Keep in mind here that peak needs are not instantaneous needs, but on average during a certain time interval, usually a certain time interval is 15 minutes, 30 minutes or 1 hour.
The characteristics of the burden between holidays are different from ordinary days so that they have different load variants. Load characteristics can also be distinguished by the factor of loading outside the time of the peak load, or who are at the time of the peak load. So we need load forecasting with the aim of preparing operating generating units. When electricity demand increases, it will be balanced with adequate electricity supply to prevent power outages, otherwise if electricity consumption decreases, electricity supply will be reduced so as not to over supply.
3. Electrical load analysis based on time series model
Box and Jenkins popularized the use of ARIMA models and the Box-Jenkins methodology became highly popular in the 1970s among academics [10]. The ARIMA model is also called the Box-Jenkins time series. A time series is a series of observations taken sequentially based on time [11]. The observation process is carried out at the same interval, for example in hour, daily, weekly, monthly, yearly or other intervals. The purpose of time series analysis is twofold, namely to model the stochastic mechanism found in observations based on time and to predict the value of observations in the future. The value of a variable can be predicted if the nature of the variable is known in the present and in the past.
3.1 ARIMA model classification
The ARIMA model is divided into several groups, namely: autoregressive (AR), moving average (MA), and ARMA. The ARIMA model is a nonstationary ARMA model that has gone through a differencing process so that it becomes a stationary model. The ARIMA model also contains seasonal patterns. Defined as a pattern that repeats in a fixed time interval. The application of this seasonal pattern has been developed into a double seasonal pattern [12, 13, 14]. Double seasonal ARIMA model is written with notation, as follows.
ARIMApdqP1D1Q1S1P2D2Q2S2E3
This model consists of two components, namely the first level which is usually developed from a linear forecasting model to explain seasonal trends from data or known as potential load. And at the second level developed from the ARIMA model to capture autoregressive patterns from data or called irregular loads. For stationary data, the seasonal factor can be determined by identifying the coefficient of autocorrelation at two or three time intervals that are very different from zero. So that this seasonal pattern can be identified whether it contains a tendency to have a seasonal pattern or multiple seasonal patterns and has the following general form [15]:
The prediction procedure of ARIMA Box-Jenkins model through five stages of iteration, as follows:
Preparation of data, including checking of data stationary
Identification of ARIMA model through autocorrelation function and partial autocorrelation function
Estimation of ARIMA model parameters: p, d, and q
Determination of ARIMA model equations
Forecasting.
3.3 Identification
Identification requires calculation and general review of the results of the autocorrelation function (ACF) and the parisal autocorrelation function (PACF). The results of these calculations are needed to determine the appropriate ARIMA model, whether ARIMA p00 or AR p, ARIMA 00q or MA q, ARIMA p0q or ARMA pq, ARIMA pdq. Meanwhile, to determine the presence or absence of the d model value, it is determined by the data itself. If the data form is stationary, d is 0, while the data form is not stationary, the value of d is not equal to 0 d>0. Likewise, the dual seasonal ARIMA model also refers to the autocorrelation function (ACF) and partial autocorrelation function (PACF) as well as knowledge of the system or process being studied.
Identification can be done after fixed time series data. The application of the model after ACF and PACF data has a tendency according to the reference to Table 1 and for the seasonal data patterns determined by referring to Table 2 [11].
ACF patterns
PACF patterns
ARIMA parameters
Heading to zero after lag q
Decreasing gradually/bumpy
ARIMA 0dq
Decreasing gradually/bumpy
Heading to zero after lag q
ARIMA pd0
Decreasing gradually/bumpy (until lag q is still different from zero)
Decreasing gradually/bumpy (until lag q is still different from zero)
ARIMA pdq
Table 1.
PACF and ACF patterns.
Model
ACF
PACF
AR p
Dies down (decreases exponentially) in seasonal lags
Cut off after lag ps
MA q
Cut off after lag qs
Dies down (decreases exponentially) in seasonal lags
ARMA pq
Dies down (decreases exponentially) in seasonal lags
Dies down (decreases exponentially) in seasonal lags
Table 2.
PACF and ACF seasonal patterns.
3.4 Parameter approximation
There are two basic ways to get this parameter:
By trial and error, test several different values and choose one of these values (or a set of values, if more than one parameter is estimated) that minimizes the sum of squared residuals.
Iterative approach, choosing an initial estimate and then letting the computer correct the iterative approximation.
3.5 Parameter testing
Parameter testing phase is to test whether the selection of parameters p, d, q is true and correct. The model is said to be good if the error value is random, meaning that it no longer has a certain pattern. In other words, the model obtained can capture well the existing data patterns. To see the error value of the test carried out testing the value of the autocorrelation coefficient of the error, using one of the following two statistics:
Q Box dan Pierce Test
Q=n′∑k=1mrk2E5
Ljung-Box Test
Q=n′n′+2∑k=1mrk2n′−kE6
Spread by chi squared χ2 with free degrees db=m−p−q−P−Q
Where
n′=n−d+SDE7
3.6 Testing criteria
If Q≤χ2αdb, meaning: error value is random (model is accepted)
If Q>χ2αdb, meaning: error value is not random (model cannot be accepted
3.7 Parameter estimation
This study uses the least squares method in estimating parameters [15]. The ARIMA model parameters are based on the time series observed with Z1,Z2,…,Z1. The quadratic method assumes that the best curve is the curve that has the least square error of the data set. The parameter values of the ARIMA models p,d, and q are determined through the stationary ACF and PACF chart plots.
3.8 Measuring accuracy level of forecasting result
Basically, to measure the accuracy of forecasting result can be done by various methods. Some statistical methods such as as Root Mean Square Error (RMSE), Mean Absolute Error (MEA) and Mean Absolute Percentage Error (MAPE). In this research. MAPE is used as a standard measurement of the accuracy offorecasting result. MAPE is defined as follows [13]
MAPE=∑i=1nZi−ẐiZin×100%E8
Where Zi and Ẑi is the actual and predicted values, while n is the number of predicted values.
3.9 Electric load cluster modeling
Cluster analysis performed in this study refers to the statistical description of the analysis technique. Descriptive statistics are methods relating to the collection and presentation of a group of data so as to provide useful information [16]. This description analysis includes several things, namely: frequency distribution, measurement of central tendency, and measurement of variability [17].
The data that has been obtained from a study which is still in the form of random data that can be made into grouped data is data that has been arranged into certain classes. Lists containing grouped data are called frequency distributions or frequency tables. Frequency distribution is the arrangement of data according to certain interval classes or according to certain categories in a list. Frequency distribution can be presented in groups, distribution based on rank order or ranking of distribution classes, distribution in groups, and distribution charts.
Measuring central tendency is a statistical analysis that specifically describes a representative score. The central tendency shows the location of the largest part of the value in the distribution including a general description of data frequencies such as mode, media, and mean or mean count.
While the measurement of variability to describe the degree of dispersion of quantitative data. This measure consists of interquartile range, quartile deviation, mean deviation, standard deviation and coefficient of variation, and variance. Measurement of variability serves to determine the homogeneity or heterogeneity of data. A data may have the same central tendency value but have different variance values.
4. DSARIMA-based load forecasting
The data used in this study is the consumption of electric power every 30 minutes during January 2, 2009 to November 19, 2011 in the Generating Unit service, the National Electricity Company in Gresik City, Indonesia.
The data is distributed on: 1. Data for training during January 2, 2009 to November 12, 2011, 2. Data for testing with the assumption of real data compared to training data from forecasting results during November 13–19, 2011.
Statistical Analysis System (SAS) is used as a simulation of electricity load forecasting and Minitab programming is used to analyze the electricity load cluster model.
4.1 Parameter identification
To identify data, the first step that must be taken is to plot the time series of the data. The time series plot is displayed to see the data patterns and stationarity of the data which aims to determine the ARIMA model. The pattern of data as shown in Figure 1 is very volatile. This condition is likely influenced by the integrated power distribution system in the Java-Madura-Bali Indonesia interconnection system.
Figure 1.
(a) Data plot of electricity usage every 30 minutes during January 2, 2009 to November 12, 2011; (b) plot of electrical load data with seasonal patterns (red box).
When referring to Figure 1(a), it can be seen that the data are not stationary in variance or mean. For more details, it will be seen in the autocorrelation function as shown in Figure 2. And if it refers to time series patterns there is a tendency for the data to contain seasonal patterns as shown in Figure 1(b).
Figure 2.
ACF plot data.
The data is not stationary in the variance, so it is necessary to transform the data as follows. Testing stationarity in variance if the p-value or λ=1. Based on the results of the transformation, the data is not stationary in the variance marked with the valueλ=−0.13 as shown in Figure 3a. After going through the process of transformation the data becomes significant with the value λ=1 as shown in Figure 3b.
Figure 3.
(a) Box-Cox transformation; (b) after transformation.
After the data is transformed it will be transformed back to get the active data value, as follows
Zt∗=Zt−0,13E9
Then
Zt=Zt∗−10013E10
The data is stationary in variance, but the transformation results in Figure 2b are not stationary in the mean. Data has not shown a constant value in the middle. The stationarity of the data can also be seen through the plot of the autocorrelation function (ACF). From Figure 2, it can be seen that the coefficient of autocorrelation is significantly different from zero and slowly decreases. The pattern shows that the data is not stationary in particular not stationary in the mean, while the ARIMA method requires data that is stationary.
The ACF plot also shows that there are strong indications of having a seasonal pattern in both daily and weekly seasonal averages as shown in Figure 4, below.
In Figure 4a, it can be seen that the electricity load data has a seasonal pattern that is the daily seasonal as seen in lags 48, 96, 144, etc. And in Figure 4b, the data also contains weekly seasonal as seen in lag 336, 672, 1008, 1344, etc.
Because the data is not stationary in the mean, it is necessary to do differencing d=1 . The ACF plot of differencing data results is shown in Figure 5 below.
Figure 5.
ACF plot after differencing d=1.
Based on the ACF plot in Figure 5, it appears that the nonseasonal data has been stationary. However, seasonal plots are still not stationary with an indication that ACF is still falling slowly in daily seasonal lags, ie lags 48, 96, 144, etc., and weekly seasonal lags, ie lags 336, 672, etc.
It is necessary to do differencing data once more in the seasonal pattern d=1D=1s=48. After going through seasonal differencing there are strong indications that the data patterns have been stationary.
Based on the ACF plot for differencing d=1D=1s=48 it is clear that the data as a whole has been stationary in the mean. The nonseasonal data plot has been stationary in lags 1, 2, 3, …, 40. The data pattern tends to dies down and will be cuts off after lag 7 and lag 8 in Figure 6a.
Figure 6.
ACF and PACF plot after differencing d=1D=1s=48
The ACF plot for seasonal patterns s=48 after differencing has also been stationary at lags 48, 96, 144, etc. The data pattern tends to be cuts off after lag 48 in Figure 6b. The seasonal pattern s=336 tends to be cuts off after lag 336 in Figure 6c.
For PACF plots both seasonal s=48 and s=336 dies down as shown in Figure 6d. Based on the provisions in Tables 1 and 2, the parameter identification results can be rewritten in the following Table 3.
Models
ACF
PACF
Estimated parameters
Nonseasonal
Dies down
Dies down
ARMA 11
Seasonal s=48
Cuts off
Dies down
MA 148
Seasonal s=336
Dies down
Dies down
MA 1336
Table 3.
Identification plots for ACF and PACF.
The ACF and PACF data plots are stationary, the alleged nonseasonal ARIMA models are in accordance with the stationary topology in Table 1 and the seasonal ARIMA in Table 2. The temporary model of ARIMA provisional model is double seasonal based on Table 3 is DSARIMA 11101148001336 . However, there is a possibility that white noise has not been fulfilled, so it is necessary to add or change the order in accordance with the test.
4.2 Parameter estimation
AR and MA coefficients in the DSARIMA model are estimated using the least squares method. The initial estimate that has been obtained is used as the initial value of the estimation method iteratively. Obtained initial estimates of AR and MA coefficients from the interim model DSARIMA (1, 1, 1) (0, 1, 1)48 (0, 0, 1)336 as shown in Table 4 in the following.
Parameter
Estimate
Standard error
t value
Approx Pr>t
Lag
MA 1.1
−0.35184
0.01899
−18.53
<0.0001
1
MA 2.1
0>95734
0.0013007
736.02
<0.0001
48
MA 3.1
−0.04526
0.0045103
−10.03
<0.0001
336
AR 1.1
−0.14,578
0.02006
−7.27
<0.0001
1
Table 4.
An output SAS of model with CLS iterative.
Based on Table 4, AR and MA parameters have met the criteria for white noise with a p-value greater than the error tolerance value α = 5%, with an alpha significance level of less than 0.0001. However, it is necessary to re-test the residual assumptions which include the white noise assumption and meet the independent criteria and are normally distributed 0σ2.
Ljung-Box Test is used to check the assumption of independence from residuals with the following hypotheses:
H0:ρ1=ρ2=…=ρK=0
H1: there is at least one ρi that is not equal to zero for i=1,2,…,K
With an error tolerance of 5%, H0 is rejected if the ρ-value <α, which means the residual does not meet the assumption of white noise. The initial residual tests are shown in Table 5 below.
To Lag
ChiSq
DF
Pr > ChiSq
ACF results
6
153.39
2
<0.0001
−0.002
−0.019
−0.041
−0.017
−0.028
−0.008
12
274.15
8
<0.0001
−0.033
−0.027
−0.0114
−0.009
−0.014
−0.007
18
342.13
14
<0.0001
−0.009
−0.009
−0.008
−0.017
−0.016
−0.023
24
422>74
20
<0.0001
−0.023
−0.018
−0.020
−0.011
−0.013
−0.003
30
43.05
26
<0.0001
−0.009
−0.008
−0.017
−0.008
−0.017
−0.014
36
489.03
32
<0.0001
−0.011
−0.009
−0.002
0.000
−0.010
0.000
42
497.60
38
<0.0001
−0.007
−0.008
0.002
−0.005
−0.004
0.003
48
804.03
44
<0.0001
0.001
0.002
0.006
0.018
0.044
0.060
Table 5.
An output SAS of model with ACF check of residuals.
Based on the estimated AR and MA coefficient parameters in Table 5, the residual normal probability plot must meet the assumption of white noise with a limit of<±1.96n≈±0.009, where n as many as 50,160 training data. Then based on the initial estimation results in Table 5, it is necessary to estimate to meet the white noise assumption, namely by including an estimate on the lag 2, 3, 4, 5, 7, 8, 9, 11, 16, 17, 18, 19, 20, 21, 22, 23, 27, 29, 30, 31, 46, 47, and 48. The results of the residual check are shown in Table 6 below. The estimation results are significant for seasonal lag, which is lag 48.
To Lag
ChiSq
DF
Pr > ChiSq
ACF results
6
—
0
—
0.000
0.000
−0.002
0.004
0.001
0.002
12
—
0
—
−0.005
−0.002
0.008
0.000
−0.007
−0.004
18
—
0
—
0.005
0.001
−0.008
0.001
−0.003
−0.003
24
18>10
5
0.0028
−0.007
−0.000
0.001
0.003
−0.001
0.002
30
24.78
11
0.0098
−0.005
−0.005
−0.002
0.009
0.0011
−0.001
36
31.03
17
0.0198
−0.005
−0.004
−0.000
−0.001
−0.004
0.008
42
33.77
23
0.0686
−0.000
−0.005
0.004
0.000
0.000
0.004
48
37.61
29
0.1314
0.005
0.006
−0.002
−0.002
0.003
−0.000
Table 6.
An output SAS of model with ACF check of residuals.
Based on residual checking, namely by adding and subtracting AR and MA parameters, it can be seen that all lags have met the assumption of white noise with a limit of <±1,96n≈±0,009 (see ACF Results). The best iteration results of the AR and MA parameters are shown in Table 7 below.
Parameter
Estimate
Standard error
t value
Approx Pr>t
Lag
MA 1.1
0.934
0.01770
52.78
<0.0001
1
MA 1.2
−0.077
0.0072138
−10.64
<0.0001
3
MA 1.3
0.008
0.0038171
2.18
0.0293
13
MA 1.4
0.00685
0.0031724
2.16
0.0309
21
MA 1.5
0.017
0.0027856
5.92
<0.0001
27
MA 1.6
0.059
0.0067600
8.67
<0.0001
46
MA 2.1
0.98
0.0009744
1003.38
<0.0001
48
MA 3.1
−0.0364
0.0045572
−7.98
<0.0001
336
AR 1.1
1.1464
0.01855
61.81
<0.0001
1
AR 1.2
−0.295
0.0087427
−33.79
<0.0001
2
AR 1.3
−0.0104
0.0052195
−2.00
0.0454
5
AR 1.4
0.0189
0.0067496
2.80
0.0051
6
AR 1.5
−0.0234
0.0047509
−4.93
<0.0001
7
AR 1.6
−0.004
0.030582
−1.29
0.1958
11
AR 1.7
−0.0083
0.0033299
−2.49
0.0126
16
AR 1.8
−0.0125
0.0033252
−3.77
0.0002
18
AR 1.9
−0.007
0.0022520
−3.26
0.0011
35
AR 1.10
0.07
0.0067089
10.62
<0.0001
46
AR 2.1
0.03
0.0050410
5.86
<0.0001
48
Table 7.
An output SAS of model with CLS iterative.
Based on Table 7, the DSARIMA model is obtained with the coefficients 12567,11,16,18,35,4611313,21,27,4611148001336, which have met the assumption of white noise.
4.3 Electrical load forecasting results
Based on the final results of the estimated parameters in Table 4 the ARIMA coefficient parameters are obtained as follows: AR (1.1) = 1.1464, AR (1.2) = − 0.295, AR (1.3) = − 0.0104, AR (1, 4) = 0.0189, AR (1.5) = − 0.0234, AR (1.6) = − 0.004, AR (1.7) = − 0.0083, AR (1.8) = − 0.0125, AR (1.9) = − 0.0074, AR (1.10) = 0.07, AR (2.1) = 0.03, MA (1.1) = 0.934, MA (1.2) = − 0.077, MA (1.3) = 0.008, MA (1.4) = 0.00685, MA (1.5) = 0.017, MA (1.6) = 0.059, MA (2.1) = 0.98, MA (3.1) = − 0.0364.
Based on the prediction model parameters obtained DSARIMA models 12567,11,16,18,35,4611313,21,27,4611148001336 with the model equation as follows:
After going through a reverse transformation Zt electrical load for the comparison of predicted results with actual data (testing) in Figure 7 below.
Figure 7.
Comparison of actual power with forecast power.
4.4 Model testing and measuring forecasting accuracy
Accuracy testing between actual power data and prediction results. Test using the MAPE procedure and obtained at 1.56 percent.
5. Electric load modeling
The application of descriptive analytic methods in this book is presented to obtain significant information in managing optimal electrical energy as the author did [18]. Through frequency distribution, data can be arranged based on certain criteria. Data categories are presented based on rank orders that contain ranking data from the top or highest load to the lowest data value.
5.1 Data distribution forecasting results
This electricity load forecasting data is a usage data for a week at intervals every half hour measurement at the power generation. This electricity load forecasting data sample is 336 (N = 336) with mean of 370.56 MWh, meaning that the value is centered at 370.526 MWh. Standard deviation of 36.2582 or the value of this deviation is not too large, this shows the diversity of data is not too large, which means the data is homogeneous.
Furthermore, forecasting the data shown in the time measurements every half-hour of electric power consumption in the load center in Figure 8 below.
Figure 8.
Plot data forecasting.
Visualizations in other forms can be displayed in the form of boxplot graphics. Figure 9 shows of range (in a box) every hour of measurement and the average value line of every half hour of measurement.
Figure 9.
Graph forecast boxplot.
Figure 9 shows that data tend to be at the minimum level, first quartile and the median value. Electricity load increases at third quartile intervals and the maximum load. This condition occurs between 18:30 until 21:30 at night.
Each measurement of electric power absorption at the load center has a peak load. Based on the measurement data, it can be seen that the peak power load absorption occurs at 19:00 and generally the peak load tendency occurs at that hour.
Henceforth processing this distribution data through seasonal data that can be presented in the form of daily data, as follows.
The sample data used is Friday data and then the data will be presented in Table 8 below.
No
Days
Mean
StDev
Median
Minimum
Peak Load
Time of peak load
1
Friday
375.143
35.4253
375.832
327.509
444.234
19:00
2
Saturday
373.635
36.2699
375.208
325.378
445.746
19:00
3
Sunday
361.193
36.8101
357.005
312.912
438.985
19:00
4
Monday
368.672
36.5413
368.417
320.639
440.478
19:00
5
Tuesday
370.616
36.2821
371.793
321.685
439.731
19:30
6
Wednesday
371.619
36.3137
372.718
322.735
441.976
19:00
7
Thursday
372.806
36.6616
374.899
323.262
442.727
19:30
Table 8.
Daily data samples.
Friday’s electricity load data—samples of electric load data are 48 (N = 48) with mean of 375.143 MWh, meaning that the value is centered at 375.143 MWh. Standard deviation of 35.4253 or the value of this deviation is not too large, this shows the diversity of data is not too large, which means the data is homogeneous.
On Friday shown in Figure 10, the peak load occurred at 19:00 amounting to 444.234 MWh with a minimum electric absorption range of 327.509 MWh. On Friday, the data has mean of 375.143 MWh.
Figure 10.
Data plot on Friday.
Furthermore, seasonal electricity load data on a daily scale can be restated in the form of Table 8 below.
5.2 Predicted cluster data
In descriptive analysis, frequency distribution, measurement of central tendencies and measurement of variability can be presented in the frequency distribution graph. The purpose of the presentation and information provided in addition to being able to describe the tendency of the data to form certain patterns, this analysis can also be used as a reference for changes in electric power in the power generation system.
The degree of data dispersion can be determined based on the range of interquartile intervals that indicate the homogeneity of the data. In this study, the electrical load cluster is defined as the range of quartile intervals to median value or is shown in the electrical load data below.
It can be seen that the data sample with N = 336 has an average of 370.53 MWh which means that the centralized data distribution is rated median. Standard deviation of 36.26 or the value of this deviation is not too large, this shows the diversity of data is not too large, which means the data is homogeneous.
Quartile intervals that divide data over median values form a cluster pattern, with the distribution of data presented in Table 9 below
Clusters
Interval range
Frequency
1
Min–Q1
97
2
Q1–Median
83
3
Median–Q3
86
4
Q3–Max
70
N = 336
Table 9.
Range of clusters in the data variant.
An important aspect of this data sample analysis is the presentation of data with seasonal variants. Data development by taking into account the seasonal variants of the hours and daily helped to optimize the management and operational decisions of the generating system both in scheduling and controlling.
6. Conclusion
One of the research trends in electrical engineering is time series analysis. This research includes forecasting studies and modeling of electrical load clusters. The time series analysis method is very suitable with the characteristics of the electrical load that is always fluctuating. This method is also able to produce different data or not included in the training data process.
For the purposes of this electrical load research, forecasting study using the DSARIMA method is an appropriate choice. This method accurately considers the seasonal parameters of the electricity load with MAPE of 1.56 percent when compared with the actual data.
Whereas the modeling of electrical load clusters based on descriptive analytic methods, obtained knowledge of the dynamics of electrical loads. The electrical load pattern has seasonal characteristics at daily and weekly intervals. This pattern forms a unique load characteristic at all times.
So, forecasting studies and modeling of electricity load clusters are able to answer the challenges of electricity energy utilization policies and the operation of generating systems that are able to maintain the balance of supply and demand.
Nomenclature
T
period of time (hours)
Paverage
average load in period T (watts)
Ppeak
peak load in the T (watts)
p,d,q
nonseasonal parts of the model
P,D,Q
seasonal parts of the model
S1,S2
1st and 2nd period seasonal
D1,D2,d
order of differences
S
number of period per season
m
maximum lag time
rk
autocorrelation or time-lag ,2,3,…,k
Zt
time series process in period T
Zt∗
forecasting process in transformation in period T
Q1
quartile 1
Q3
quartile 3
Greek symbols
λ
Box-Cox transformation number
αt
white noise
θqB
regular MA polynomials of order q
ΘQ1BS1,ΘQ2BS2
MA polynomials of orders
φpB
regular AR polynomials of orders p
ΦP1BS1,ΦP2BS2
AR polynomials of orders
MAPE
mean absolute percentage error
MWh
mega watt hours
\n',keywords:"electric loads, DSARIMA model, descriptive analytic, clustering, forecasting, time series",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73635.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73635.xml",downloadPdfUrl:"/chapter/pdf-download/73635",previewPdfUrl:"/chapter/pdf-preview/73635",totalDownloads:435,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:51,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"May 22nd 2020",dateReviewed:"July 27th 2020",datePrePublished:"October 16th 2020",datePublished:"January 27th 2021",dateFinished:"October 16th 2020",readingETA:"0",abstract:"Electricity consumption always changes according to need. This pattern deserves serious attention. Where the electric power generation must be balanced with the demand for electric power on the load side. It is necessary to predict and classify loads to maintain reliable power generation stability. This research proposes a method of forecasting electric loads with double seasonal patterns and classifies electric loads as a cluster group. Double seasonal pattern forecasting fits perfectly with fluctuating loads. Meanwhile, the load cluster pattern is intended to classify seasonal trends in a certain period. The first objective of this research is to propose DSARIMA to predict electric load. Furthermore, the results of the load prediction are used as electrical load clustering data through a descriptive analytical approach. The best model DSARIMA forecasting is ([1, 2, 5, 6, 7, 11, 16, 18, 35, 46], 1, [1, 3, 13, 21, 27, 46]) (1, 1, 1)48 (0, 0, 1)336 with a MAPE of 1.56 percent. The cluster pattern consists of four groups with a range of intervals between the minimum and maximum data values divided by the quartile. The presentation of this research data is based on data on the consumption of electricity loads every half hour at the Generating Unit, the National Electricity Company in Gresik City, Indonesia.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73635",risUrl:"/chapter/ris/73635",book:{id:"10062",slug:"forecasting-in-mathematics-recent-advances-new-perspectives-and-applications"},signatures:"Ismit Mado",authors:[{id:"321882",title:"Dr.",name:"Ismit",middleName:null,surname:"Mado",fullName:"Ismit Mado",slug:"ismit-mado",email:"ismitmado@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Electrical load characteristics",level:"1"},{id:"sec_2_2",title:"2.1 Load factor",level:"2"},{id:"sec_3_2",title:"2.2 Daily load",level:"2"},{id:"sec_4_2",title:"2.3 Load curve",level:"2"},{id:"sec_5_2",title:"2.4 Peak load",level:"2"},{id:"sec_7",title:"3. Electrical load analysis based on time series model",level:"1"},{id:"sec_7_2",title:"3.1 ARIMA model classification",level:"2"},{id:"sec_8_2",title:"3.2 ARIMA Box-Jenkins procedure",level:"2"},{id:"sec_9_2",title:"3.3 Identification",level:"2"},{id:"sec_10_2",title:"3.4 Parameter approximation",level:"2"},{id:"sec_11_2",title:"3.5 Parameter testing",level:"2"},{id:"sec_12_2",title:"3.6 Testing criteria",level:"2"},{id:"sec_13_2",title:"3.7 Parameter estimation",level:"2"},{id:"sec_14_2",title:"3.8 Measuring accuracy level of forecasting result",level:"2"},{id:"sec_15_2",title:"3.9 Electric load cluster modeling",level:"2"},{id:"sec_17",title:"4. DSARIMA-based load forecasting",level:"1"},{id:"sec_17_2",title:"4.1 Parameter identification",level:"2"},{id:"sec_18_2",title:"4.2 Parameter estimation",level:"2"},{id:"sec_19_2",title:"4.3 Electrical load forecasting results",level:"2"},{id:"sec_20_2",title:"4.4 Model testing and measuring forecasting accuracy",level:"2"},{id:"sec_22",title:"5. Electric load modeling",level:"1"},{id:"sec_22_2",title:"5.1 Data distribution forecasting results",level:"2"},{id:"sec_23_2",title:"5.2 Predicted cluster data",level:"2"},{id:"sec_25",title:"6. Conclusion",level:"1"},{id:"sec_28",title:"Nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'Tsekouras GJ, Dialynas EN, Hatziargyriou ND, Kavatza S. A on-linier multivariable regression model for midterm energy forecasting of power systems. Electric Power Systems Research. 2007;77(12):1560-1568'},{id:"B2",body:'McSharry PE, Bouwman S, Bloemhof G. Probabilistic forecasts of the magnitude and timing of peak electricity demand. 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Statistik Pendidikan, Buku Ajar Mata Kuliah Statistik. 2001'},{id:"B18",body:'Mado I, Soeprijanto A, Suhartono S. Electrical load adat clustering in PJB UP Gresik based on time series analysis approach. In: Proceedings of the International Conference on Vocational Education and Electrical Engineering. Surabaya, Indonesia; 2015. pp. 261-266. Available from: http://digilib.unimed.ac.id/23841/1/Fulltext.pdf'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ismit Mado",address:"ismitmado@borneo.ac.id",affiliation:'
University Borneo Tarakan, Tarakan City, Indonesia
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1. Introduction
Secondary metabolites are natural products synthesized mainly by plants, fungi and bacteria. Secondary metabolites are molecules with low molecular weight and various biological activities and chemical structures [1]. Secondary metabolites are also called specialized metabolites; they generally mediate ecological interactions by increasing their ability to survive [2]. Secondary metabolites function as a defense against herbivores and other interspecies in plants; and it was first established by A. kossel in 1910, and was discovered 20 years later as an end product of nitrogen metabolism by Friedrich Czapek a Botanist [3].
2. Plant secondary metabolites
Plants are capable of manufacturing diverse types of organic compounds which are grouped into primary and secondary metabolites [3]. Some secondary metabolites are phenylpropanoids or cinnamic acids, which protect plants from UV damage [4]. Since ancient times, the plant secondary metabolite’s biological effects in humans have been known. The herb Artemisia annua contains Artemisinin, which is widely used in herbal or traditional medicine. Plant secondary metabolites can be divided into four major classes: alkaloids, phenolic compounds, terpenes, and glucosinolates [5, 6].
2.1 Alkaloids
Plants are natural products and the oldest source of alkaloids, examples of the most widely recognized alkaloids are morphine, quinine, strychnine, and cocaine [7]. Alkaloids are present as water-soluble salts of organic acids, esters, tannins (Cinchona bark) or in plant tissues [7, 8].
Most alkaloids are isolated in the form of crystalline, non-odorous, nonvolatile and amorphous compounds, low molecular weight alkaloids, such as arecoline and pilocarpine, non-oxygen atom alkaloids such as sparteine and nicotine occur in the liquid form, these are all from plant matrices. Majority of alkaloids are colorless with a bitter taste, apart from colchicine and berberine. Alkaloids are derived from plant sources and a diverse group of nitrogen-containing basic compounds, which contain one or more nitrogen atoms. Chemically they are heterogeneous. Based on chemical structures, they are classified into two broad categories [9]:
Examples of plants with alkaloids include, Datura stramonium, Atropa belladonna, Erythroxylum coca, Solanaceae (nightshade) plant family, Papaver somniferum, and Catharanthus roseus [9].
Alkaloids (about 20,000) are isolated from plants, but it have also been found in microorganisms, marine organisms such as algae, dinoflagellates, and pufferfish, and terrestrial animals such as insects, salamanders, and toads [10].
Classification based on the botanical origin of the alkaloids, their Sources and pharmacological properties are listed below (Table 1). For example., Papaver (opium)alkaloids, Cinchona alkaloids, Rauvolfia alkaloids, Catharanthus alkaloids, Strychnos alkaloids, Ergot alkaloids, cactus alkaloids, and Solanum alkaloids [10], while the structures of some alkaloids are shown in Figure 1.
Alkaloid
Source
Properties
Ajmaline
Rauvolfia serpentina
Antiarrhythmic, antihypertensive
Caffeine
Coffea arabica
Stimulant, insecticide
Camptothecin
Camptotheca acuminata
Antineoplastic
Cocaine
Erythroxylon coca
Analgesic, narcotic, local anesthetic
Codeine
Papaver somniferum
Analgesic, antitussive
Emetine
Uragoga ipecacuanha
Antiamoebic, expectorant, emetic
Hyoscyamine
Atropa belladonna and others
Anticholinergic
Morphine
P. somniferum
Analgesic, narcotic
Nicotine
Nicotiana tabacum
Stimulant
Pilocarpine
Pilocarpus jaborandi
Cholinergic
Quinidine
Cinchona spp.
Antiarrhythmic
Quinine
Cinchona spp.
Antimalarial
Reserpine
R. serpentina
Tranquilizer
Scopolamine
Hyoscyamus niger and others
Sedative, anticholinergic
Strychnine
Strychnos nux-vomica
Stimulant, poison
Taxol
Taxus brevifolia
Antineoplastic
Vinblastine and vincristine
Catharanthus roseus
Antineoplastic
Table 1.
Spurces and pharmacological uses of selected plant-derived alkaloids.
Figure 1.
Structures of some alkaloids. Note that the structures of morphine and codeine are based on the same skeleton, but are decorated with different functional groups in the position represented by ‘R’. In morphine, this group is −OH, while in codeine it is CH2O. Similarly, vinblastine and vincristine are based on the same skeleton, but differ in the nature of the R-group, which for vinblastine is −CH3 and for vincristine is −CHO.
2.2 Phenolic compounds
Plant secondary metabolism produces phenolic compounds with chemical structures of one hydroxyl aromatic ring. These phenolic compounds are classified based on their carbon chain. [11]. Phenolic compounds are found in plant tissues, fruits and vegetables and are also ubiquitously distributed phytochemicals. Phenolic compounds are synthesized through phenylpropanoid and shikimic acid pathways [12]. Phenolic compounds possess numerous bioactive properties and health-protective effects, although they are not nutrients, therefore postharvest treatments have been used to enhance or preserve the phenolic compounds in fruits and vegetables [12]. Phenolic compounds possess an aromatic ring with one or more hydroxyl substituents that can be divided into several classes, which are common chemical structures essential for health benefits [13].
Plant materials like (Tropical Root and Crops) contain two classes of phenolic compounds as hydroxybenzoic acids and hydroxycinnamic acids. Phenolic compounds are present in Nigerian Centaurea perrottetii DC. [family COMPOSITAE] and other related genera (Cheirolophus, Rhaponticoides, and Volutaria) [14].
The phenolic compounds found in plants are represented in Table 2, while the categories of phenolic compounds and their representative compounds are shown in Figure 2. Phenolic compounds survive in plant material, in either a soluble or a bound form [15, 16].
Grape seed/skin, apple juice, strawberries, raspberries, pomegranate, walnuts, peach, blackberry, and plum
Lignans
Secoisolariciresinol Matairesinol
Pear
Table 2.
Selected phenolic compounds found in plants.
Figure 2.
Categories of phenolic compounds.
2.3 Terpenoids
Terpenes are a unique group of hydrocarbon-based natural products whose structures are derived from isoprene. Terpenoid secondary metabolites occur in plant tissue types often secured in secretory structures [17]. Over 30,000 members of terpenes are in an enormous class of natural products, they have been used for a broad variety of purposes including medicine, flavoring and perfume [18]. Terpenes as a broad group with ecological roles, that exhibit a range of deadly to entirely edible toxicity, which include antimicrobial properties and other properties [19, 20].
Plants and flowering plants (angiosperms) subdivisions have colonized the majority of the terrestrial surface, courtesy of rich levels of specialization and the relationships with other organisms [21].
Terpenes are important plant metabolites that include substances like floral fragrances that serve as plant hormones (gibberellic and abscisic acid), growth inhibitors, insect attractants, pine oil, and insecticides [22].
Terpenoids or isoprenoids are high in plants where many can be considered secondary metabolites and have fundamental roles in the metabolism of all organisms [23]. Terpenoid secondary metabolism in plants began with the recruitment of genes from primary metabolism [24] and accelerated due to the proliferation of cytochrome P450 and terpene synthase gene families in the genomes of plants [25].
Terpenoids play various physiological and ecological functions in plant life and human through direct and indirect plant defenses, because of their enormous applications in the pharmaceutical, food and cosmetics industries [26]. Examples of terpenoids from plant species are 1). Artemisinin, present in A. annua, Chinese wormwood. 2). Tetrahydrocannabinol, present in Cannabis sativa, cannabis. 3). Azadirachtin, present in Azadirachta indica, the (Neem tree). 4). Saponins, glycosylated triterpenes present in Chenopodium quinoa, quinoa [27, 28].
2.4 Glucosinolates
The pungent smell of plants (mustard, cabbage, and horseradish) is due to mustard oils produced from glucosinolates [29]. Glucosinolates are biosynthesized from amino acids, which consists of three glucosinolate subtypes (aliphatic, indole and aromatic glucosinolates) that have their corresponding precursors. Aliphatic glucosinolates are derived from isoleucine, alanine, valine, methionine, and leucine. Indole and aromatic glucosinolates are obtained from phenylalanine or tyrosine and tryptophan. Examples of the three classes of glucosinolates represented by 3methylsulfinylpropyl glucosinolate; indol3ylmethyl glucosinolate; and benzyl glucosinolate in Figure 3.
Figure 3.
Glucosinolates.
Glucosinolates are responsible for the pungent properties present in mustard, rucola, horseradish, cruciferous vegetables, and nasturtium and they are sulfur and nitrogen-containing glycosides, which protect against carcinogenesis [30].
The glucosinolates of sulforaphane (Glucoraphanin) present in broccoli, cabbage, and cauliflower (cruciferous vegetables) are responsible for protection against carcinogenesis. The Brown (Brassica juncea), white (Brassica alba) and black (Brassica nigra) mustards are examples of mustard seed with the family Brassicaceae [31, 32].
Secondary metabolites in plants (glucosinolates, isothiocyanates, S-methyl cysteine, allyl sulfurs, phytates, phytoestrogens) likely to protect against cancers, and antioxidant properties (phenolic compounds, flavonoids) [32].
Isothiocyanates are present in cruciferous vegetables, which is the product of the degradation of glucosinolates. S-methyl cysteine is a sulfur-containing phytochemicals found in all brassica vegetables [33, 34].
Glucosinolates contain metabolites found in the plant Arabidopsis thaliana. The strong taste of foods (horseradish, wasabi, and mustard) is as a result of glucosinolates [35, 36].
Over 130 glucosinolate compounds have been identified in plants, and one way that they vary is by the amino acid precursor that is incorporated during glucosinolates biosynthesis [37].
3. Fungal secondary metabolites
Fungi are eukaryotic organisms that can utilize various solid substrates of their biochemical and biological evolution and are also known to inhabit almost all ecological niches of the Earth. Some of the solid substrates utilized by fungi are decaying and dead material, such as live plants (endophytic, parasitic, and mycorrhizal fungi), lichens (lichenicolous and endolichenic fungi), insects (entomopathogenic fungi) and herbivore dung (saprophytic and coprophilous fungi). A characteristic feature of many of these fungi (filamentous growth and complex morphology), is their ability to produce secondary metabolites which are useful in pharmaceutical, agrochemical industries and food with different biological activities [38, 39].
In the production of secondary metabolites which occurs after fungal growth has stopped because of nutrient limitations but an abundant carbon source available, it is then possible to manipulate their formation. Some endophytic fungi can produce secondary metabolites known from plants. Examples include production paclitaxel (Taxol®) and camptothecin, by Taxomyces andreanae and Nothapodytes foetida, respectively, and a synthetic precursor of an anticancer drug, podophyllotoxin, by Phialocephala fortinii [39].
The several classes of fungal secondary metabolites are polyketides (aflatoxin and fumonisins), nonribosomal peptides (sirodesmin, peramine, siderophores) and terpenes (T-2 toxin, deoxynivalenol (DON)), indole terpenes (paxiline and lolitrems) as represented in Figure 4. Polyketides are building blocks of natural products and are the largest group of metabolites occurring in their greatest number. They are the most sought-after molecules because of their wide spectrum of activities (clinical, industrial and economical activities). Non-ribosomal peptides are catalyzed without mRNA template by a complex enzyme called Nonribosomal peptide-synthetase (NRPS) enzymes. The peptide is modified by accessory enzymes similar to polyketides and often includes noncanonical amino acids. Nonribosomal peptide-synthetase (NRPS) enzymes include B-lactam antibiotics, cyclosporine A and echinocandin [40, 41].
Figure 4.
Several classes of fungal secondary metabolites; a) Polyketides b) non-ribosomal peptides c) Terpenes and d) Indole terpenes.
The first FDA-approved secondary metabolite was Lovastatin, to lower cholesterol levels. In oyster mushrooms [42], red yeast rice [43], and Pu-erh [44], Lovastatin occurs naturally in low concentrations. Their mode of action is inhibition of HMG-CoA reductase, and it is the enzyme responsible for converting HMG-CoA to mevalonate.
Fungal secondary metabolites are dangerous to humans. The fungi Claviceps purpurea, a member of the ergot group, typically growing on rye, when ingested results in the death of humans. In C. purpurea, a build-up of poisonous alkaloids lead to spasms and seizures, Itching, diarrhea, psychosis or gangrene and paresthesias [45].
Fungi are organisms that produce a wide range of natural products often called secondary metabolites; many natural products are of agricultural, medical, and industrial importance. Examples of natural products causing harm (mycotoxins), while others are advantageous (antibiotics) to humans [46, 47]. The biosynthesis of natural products is usually associated with cell differentiation or development, the establishment of a G-protein-mediated growth pathway in Aspergillus nidulans regulates both asexual sporulation and natural product biosynthesis [48].
Secondary metabolism is connected with sporulation processes in microorganisms [49, 50], including fungi [51, 52]. Secondary metabolites connected with sporulation can be classified into three groups: (i) Sporulation activated by metabolites (A. nidulans [53, 54, 55, 56]), (ii) Sporulation structures from pigments (melanins [57, 58]), and (iii) toxic metabolites secreted at the time of sporulation by growing colonies (the biosynthesis of some deleterious natural products, such as mycotoxins [48, 59]). These examples of fungal secondary metabolites are shown in Table 3.
Secondary metabolite
Producing fungus
Association with development
References
Linoleic-acid derived psi factor
Aspergillus nidulans
Induces sporulation; affects ratio of asexual to sexual spore development
Natural products are essential for sporulation, examples of fungal strains that are sporulated and deficient in secondary metabolite production are Penicillium urticae patulin mutants [52] and A. nidulans sterigmatocystin mutants [67]. Secondary metabolites such as brevianamides A and B produced by Penicillium brevicompactum [60], some natural products have subtle effects on sporulation, as recent studies of A. nidulans sterigmatocystin mutants suggest that they display a decrease in asexual spore production [61, 62].
Secondary metabolites have easily visible effects on morphological differentiation in fungi, mycelium excretes compounds that can prompt sexual and asexual sporulation in other fungi [63, 64, 65], these compounds have not been identified but are assumed to be natural products produced as the mycelia ages. Other natural product such as Fusarium graminearum enhances perithecial production in F. graminearum and produces an estrogenic mycotoxin called zearalenone, an inhibitor of zearalenone synthesis, which inhibits the sexual development of this fungus [66].
Butyrolactone I, produced by the fungus Aspergillus terreus, is an inhibitor of eukaryotic cyclin-dependent kinases, which increases sporulation [68]. Some secondary metabolites trigger sporulation and influence the development of the producing organism and neighboring members of the same species. Natural product biosynthetic gene clusters can be conserved between organisms, for example, the sterigmatocystin-aflatoxin biosynthetic gene cluster in several Aspergillus spp. [69].
4. Bacterial secondary metabolites
The bacterial secondary metabolites are natural products source of anticholesterol agents, immune suppressants, antibiotics, antitumor agents, and other medicines; secondary metabolite-producing microorganisms synthesize these bioactive and complex molecules at the late phase and stationary phase of their growth [70, 71, 72] as shown in Figure 5a. In bacteria, the actinomycetes (streptomycetes) produce a significant number of chemically distinct secondary metabolites [73, 74, 75, 76]. Other major sources include soil pseudomonas, bacilli, and myxococci [77, 78, 79, 80]. An example of a bacterial secondary metabolite is botulinum toxin synthesized by Clostridium botulinum, with a positive and negative effect on humans. However, botulinum toxin has multiple medical uses for the treatment of muscle spasticity, migraine and cosmetics use [81].
Figure 5.
a) the secondary metabolite-producing microorganisms synthesize these bioactive and complex molecules at the late phase and stationary phase of their growth. b) Secondary metabolic pathway reactions are conducted by an individual enzyme or multienzyme complexes. Intermediate or end-products of primary metabolic pathways are channeled from their systematic metabolic pathways that lead to the synthesis of secondary metabolites.
Bacterial production of secondary metabolites starts in the stationary phase in response to environmental stress and lack of nutrients. Secondary metabolite synthesis in bacteria, allow them to better interact with their ecological niche and it is not essential for their growth. The b-lactam, shikimate, polyketide and non-ribosomal are the synthetic pathways for secondary metabolite production [82] as shown in Figure 5b. B-lactam family of cephalosporins antibiotics have been used to treat bacterial infections for 40 years and above. Gram-positive bacteria, Gram-negative bacteria, and fungi are the major sources of b-lactam antibiotics. The shikimate pathway contributes to the basic building blocks for aromatic metabolites and amino acids, which can serve as antibacterial agents. In the bacterial secondary metabolite, two enzymes can transfer a complete enolpyruvoyl moiety to a metabolic pathway, 5-enolpyruvoyl shikimate 3-phosphate synthase and chorismate synthase that require a reduced cofactor, flavin mononucleotide, for its activation. When secreted those found in the prokaryotic cell wall are endotoxins, while those poisonous compounds are known as exotoxins. Other examples of bacterial secondary metabolites are phenazine, polyketides, nonribosomal peptides, ribosomal peptides, glucosides, and alkaloids.
4.1 Phenazine
Bacteria are natural phenazines, phenazines are heterocyclic, nitrogenous compounds that differ in their physical and chemical properties. Phenazines are significant for their potential impact on bacterial interactions and biotechnological processes. It exhibits a wide range of biological activities, Pyocyanin, from Pseudomonas aeruginosa. Other phenazines from Pseudomonas sp. and Streptomyces sp. (Natural Products of Actinobacteria Derived from Marine Organisms) [83].
Phenazines produced by various bacteria species and excrete them in high quantities in the environment in a visible form to the naked eye, they are nitrogen-containing colored aromatic secondary metabolites. The main use of phenazines is to protect plants (biocontrol field), because of their antimicrobial properties. Examples of bacteria species able to produce phenazines are Pseudomonas spp. (including P. aeruginosa,P. fluorescens, and Pseudomonas chlororaphis) [84].
4.2 Polyketides
Polyketides from plants, bacteria, fungi, and animals, are a large group of secondary metabolites known to possess remarkable properties [85, 86]. Polyketides possess some bioactivities such as antibacterial (e.g., tetracycline), antifungal (e.g., amphotericin B), immune-suppressing (e.g., rapamycin), anti-cholesterol (e.g., lovastatin), anti-inflammatory activity (e.g., flavonoids), antiviral (e.g., balticolid), and anticancer (e.g., doxorubicin) [87, 88, 89, 90, 91, 92, 93]. Some organisms that can produce polyketides are plants (e.g., emodin from Rheum palmatum), fungi (e.g., lovastatin from Phomopsis vexans), bacteria (e.g., tetracycline from Streptomyces aureofaciens), protists (e.g., maitotoxin-1 from Gambierdiscus australes), mollusks (e.g., elysione from Elysia viridis), and insects (e.g., stegobinone from Stegobium paniceum) [94, 95, 96, 97, 98, 99]. These organisms can use the polyketides they produce for pheromonal communication in the case of insects and also as protective compounds.
Polyketides are a family of natural products which are synthesized by polyketide synthase (PKS) enzymes with different biological activities and pharmacological properties. They are divided into three types: type I polyketides (macrolides produced by multimodular megasynthases), type II polyketides (aromatic molecules produced by the iterative action of dissociated enzymes), and type III polyketides (small aromatic molecules produced by fungal species) [100]. Polyketides are also found in bacteria, fungi, plants, mollusks, protists, sponges, and insects. They have notable variety in their structure and function. Some examples of polyketides antibiotics are Erythromycin, Avermectin, Nystatin, and Rifamycin [100].
4.3 Nonribosomal peptides
Nonribosomal peptides (NRPs) are peptide secondary metabolites that are synthesized by nonribosomal peptide synthetases (NRPSs) (multidomain mega-enzymes), without messenger RNAs and cell ribosomal machinery [101]. Nonribosomal peptides are naturally synthesized by bacteria, fungi, and higher eukaryotes [101]. Nonribosomal peptides are also synthesized by indigoidine (pigment). Some examples of nonribosomal peptide antibiotics are; Vancomycin, bacterium, Ramoplanin, Teicoplanins, Gramicidin, Bacitracin, Polymyxin [102].
4.4 Ribosomal peptides
Streptomyces azureus is produced from several strains of streptomycetes (Thiostrepton), Escherichia coli produced from Microcins and Bacteriocins [82].
4.5 Glucosides
Streptomyces species produced from Nojirimycin [82].
4.6 Alkaloids
Pseudoalteromonas produced by Tetrodotoxin, a neurotoxin [82].
5. Conclusion
Natural products originate as secondary metabolites Plants possess different indigenous defensive mechanisms to cope with certain environmental stresses. Secondary metabolites are natural tools used by plants to combat biotic and abiotic stresses. Microorganisms can produce several antibiotics and other pharmaceutically important drugs to treat bacterial and fungal infections. The secondary metabolites from natural products help us to understand their classes, sources, pharmacological importance and examples associated with the secondary metabolites derived from plants, fungi, and bacteria.
\n',keywords:"secondary metabolites, natural products, alkaloids, phenolic compounds, terpenes",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/80477.pdf",chapterXML:"https://mts.intechopen.com/source/xml/80477.xml",downloadPdfUrl:"/chapter/pdf-download/80477",previewPdfUrl:"/chapter/pdf-preview/80477",totalDownloads:104,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 1st 2021",dateReviewed:"December 20th 2021",datePrePublished:"February 16th 2022",datePublished:null,dateFinished:"February 15th 2022",readingETA:"0",abstract:"Natural products are substances that are confined from living organisms, they are in the form of primary or secondary metabolites. Secondary metabolites are compounds with varied chemical structures, produced by some plants and strains of microbial species. Unlike primary metabolites (nucleotides, amino acids, carbohydrates, and lipids) that are essential for growth, secondary metabolites are not. Secondary metabolites are produced or synthesized during the stationary stage. In this chapter, we will discuss secondary metabolites from natural products synthesized mainly by plants, fungi, and bacteria. Plants synthesize a large diversity of secondary metabolites; plant secondary metabolites are split into four groups namely alkaloids, phenolic compounds, terpenoids, and glucosinolates. Several classes of fungal and bacterial secondary metabolites, their sources, and pharmacological uses associated with the secondary metabolites are also discussed. Therefore, several classes of secondary metabolites are responsible for the biological and pharmacological activities of plants and herbal medicines.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/80477",risUrl:"/chapter/ris/80477",signatures:"Stella Omokhefe Bruce",book:{id:"11331",type:"book",title:"Secondary Metabolites - Trends and Reviews",subtitle:null,fullTitle:"Secondary Metabolites - Trends and Reviews",slug:null,publishedDate:null,bookSignature:"Dr. Ramasamy Vijayakumar and Dr. Suresh Selvapuram Sudalaimuthu Raja",coverURL:"https://cdn.intechopen.com/books/images_new/11331.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-208-8",printIsbn:"978-1-80355-207-1",pdfIsbn:"978-1-80355-209-5",isAvailableForWebshopOrdering:!0,editors:[{id:"176044",title:"Dr.",name:"Ramasamy",middleName:null,surname:"Vijayakumar",slug:"ramasamy-vijayakumar",fullName:"Ramasamy Vijayakumar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"341144",title:"Dr.",name:"Stella Omokhefe",middleName:null,surname:"Bruce",fullName:"Stella Omokhefe Bruce",slug:"stella-omokhefe-bruce",email:"stellaobruce@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Plant secondary metabolites",level:"1"},{id:"sec_2_2",title:"2.1 Alkaloids",level:"2"},{id:"sec_3_2",title:"2.2 Phenolic compounds",level:"2"},{id:"sec_4_2",title:"2.3 Terpenoids",level:"2"},{id:"sec_5_2",title:"2.4 Glucosinolates",level:"2"},{id:"sec_7",title:"3. Fungal secondary metabolites",level:"1"},{id:"sec_8",title:"4. Bacterial secondary metabolites",level:"1"},{id:"sec_8_2",title:"4.1 Phenazine",level:"2"},{id:"sec_9_2",title:"4.2 Polyketides",level:"2"},{id:"sec_10_2",title:"4.3 Nonribosomal peptides",level:"2"},{id:"sec_11_2",title:"4.4 Ribosomal peptides",level:"2"},{id:"sec_12_2",title:"4.5 Glucosides",level:"2"},{id:"sec_13_2",title:"4.6 Alkaloids",level:"2"},{id:"sec_15",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Návarová H, Bernsdorff F, Döring AC, Zeier J. Pipecolic acid, any endogenous mediator of defense amplification and priming, is a critical regulator of inducible plant immunity. 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Targeted disruption of a melanin biosynthesis gene affects conidial development and UV tolerance in the Japanese pear pathotype of Alternaria alternata. Molecular Plant-Microbe Interactions. 1999;12:59-63'},{id:"B59",body:'Trail F, Mahanti N, Linz J. Molecular biology of aflatoxin biosynthesis. Microbiology. 1995;141:755-765'},{id:"B60",body:'Bird BA, Remaley AT, Campbell IM. Brevianamides A and B are formed only after conidiation has begun in solid cultures of Penicillium brevicompactum. Applied and Environmental Microbiology. 1981;42:521-525'},{id:"B61",body:'Ramaswamy A. Ecological analysis of secondary metabolite production in Aspergillus spp. Master\'s thesis. College Station: Office of Graduate Studies of Texas A & M University; 2002'},{id:"B62",body:'Sim SC. Characterization of Genes in the Sterigmatocystin Gene Cluster and Their Role in Fitness of Aspergillus nidulans. Master’s thesis. College Station: Office of Graduate Studies of Texas A & M University; 2001'},{id:"B63",body:'Hadley G, Harrold CE. The sporulation of Penicillium notatum westling in submerged liquid cultures. Journal of Experimental Botany. 1958;9:418-428'},{id:"B64",body:'Park D, Robinson PM. Sporulation in Geotrichum candidum. Br. Mycol. Soc. 1969;52:213-222'},{id:"B65",body:'Onyegbule FA, Okoli OG, Bruce SO. In vivo evaluation of the antimalarial activity of the aqueous ethanol extract of Monodora myristica seed in Albino Mice. International Journal of Science and Research (IJSR). 2019;8(6):1530-1538'},{id:"B66",body:'Wolf JC, Mirocha CJ. Regulation of sexual reproduction in Gibberella zeae (Fusarium roseum ‘Graminearum’) by F-2 (zearalenone). Canadian Journal of Microbiology. 1973;19:725-734'},{id:"B67",body:'Shimizu K, Keller NP. Genetic involvement of cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. 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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
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Open Access Funding
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For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
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Indexing and listing across major repositories, see details ...
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Long-term archiving
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Live Performance Metrics to track readership and the impact of your chapter
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Dissemination and Promotion
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Benefits of Publishing with IntechOpen
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Proven world leader in Open Access book publishing with over 10 years experience
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+184,650 citations in Web of Science databases
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It explains principles of communication, communication process, purpose of communication, types of communication, barriers to effective communication, models of communication and strategies of improving communication and guidelines for successful therapeutic interactions.",book:{id:"6615",slug:"nursing",title:"Nursing",fullTitle:"Nursing"},signatures:"Maureen Nokuthula Sibiya",authors:[{id:"73330",title:"Dr.",name:"Nokuthula",middleName:null,surname:"Sibiya",slug:"nokuthula-sibiya",fullName:"Nokuthula Sibiya"}]},{id:"19615",title:"Everything Under Control: How and When to Die - A Critical Analysis of the Arguments for Euthanasia",slug:"everything-under-control-how-and-when-to-die-a-critical-analysis-of-the-arguments-for-euthanasia",totalDownloads:6576,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"242",slug:"euthanasia-the-good-death-controversy-in-humans-and-animals",title:"Euthanasia",fullTitle:'Euthanasia - The "Good Death" Controversy in Humans and Animals'},signatures:"Josef Kuře",authors:[{id:"30926",title:"Prof.",name:"Josef",middleName:null,surname:"Kuře",slug:"josef-kure",fullName:"Josef Kuře"}]},{id:"19620",title:"Debate For and Against Euthanasia in the Control of Dog Populations",slug:"debate-for-and-against-euthanasia-in-the-control-of-dog-populations",totalDownloads:12576,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"242",slug:"euthanasia-the-good-death-controversy-in-humans-and-animals",title:"Euthanasia",fullTitle:'Euthanasia - The "Good Death" Controversy in Humans and Animals'},signatures:"Antonio Ortega-Pacheco and Matilde Jiménez-Coello",authors:[{id:"30340",title:"Dr.",name:"Matilde",middleName:null,surname:"Jimenez-Coello",slug:"matilde-jimenez-coello",fullName:"Matilde Jimenez-Coello"},{id:"30393",title:"Dr.",name:"Antonio",middleName:null,surname:"Ortega-Pacheco",slug:"antonio-ortega-pacheco",fullName:"Antonio Ortega-Pacheco"}]},{id:"61494",title:"Transcultural Nursing",slug:"transcultural-nursing",totalDownloads:2688,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Culture is defined as the sum of all the material and spiritual values created in the process of social development and the tools that are used to create and hand these values down to next generations and show the extent of the man’s authority and control over their natural and social environment. The term “culture”, which diversifies in each community and so is experienced differently, also affects the way individuals perceive the phenomena such as health, illness, happiness, sadness and the manner these emotions are experienced. The term health, whose nature and meaning is highly variable across different cultures requires care involving cultural recognition, valueing and practice. The nursing profession, which plays an important role in the health team, is often based on a cultural phenomenon. The cultural values, beliefs and practices of the patient are an integral part of holistic nursing care. The aim of nursing is to provide a wholly caring and humanistic service respecting people’s cultural values and lifestyles. Nurses should offer an acceptable and affordable care for the individuals under the conditions of the day. Knowing what cultural practices are done in the target communities and identifying the cultural barriers to offering quality health care positively affects the caring process. Nurses should explore new ways of providing cultural care in multicultural societies, understand how culture affects health-illness definitions and build a bridge for the gap between the caring process and the individuals in different cultures.",book:{id:"6615",slug:"nursing",title:"Nursing",fullTitle:"Nursing"},signatures:"Vasfiye Bayram Değer",authors:[{id:"228268",title:"Associate Prof.",name:"Vasfiye",middleName:null,surname:"Bayram Değer",slug:"vasfiye-bayram-deger",fullName:"Vasfiye Bayram Değer"}]},{id:"72954",title:"Value-Based Healthcare",slug:"value-based-healthcare",totalDownloads:832,totalCrossrefCites:0,totalDimensionsCites:3,abstract:"Value-based healthcare is a new health-care model in which what is important is value to the patient. Value is a broad term, but in essence, it is the best outcome for the patient per dollar spent. To provide value to the patient, the medical practice should be centered around conditions and care cycles and the results must be measured. We now know that the model we have right now, the fee-for-service model, is not linked to quality of the patient. All around the world, many hospitals and clinics are making the transition to this value-based model. To provide the best for the patient, we must have the best medical evidence to follow. In the following chapter, we will cover a few aspects of value-based healthcare, its reimbursement model, the integrated practice units, and the information technology necessary to implement it.",book:{id:"9566",slug:"bioethics-in-medicine-and-society",title:"Bioethics in Medicine and Society",fullTitle:"Bioethics in Medicine and Society"},signatures:"Patrick Rech Ramos",authors:[{id:"321359",title:"Dr.",name:"Patrick",middleName:"Rech",surname:"Rech Ramos",slug:"patrick-rech-ramos",fullName:"Patrick Rech Ramos"}]}],onlineFirstChaptersFilter:{topicId:"167",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81683",title:"An Examination of Safe Injection Sites and Ethical Issues in Philadelphia, United States",slug:"an-examination-of-safe-injection-sites-and-ethical-issues-in-philadelphia-united-states",totalDownloads:13,totalDimensionsCites:0,doi:"10.5772/intechopen.104565",abstract:"The opioid epidemic in the United States has been an ever-increasing public health crisis. Despite being a major issue in the United States for decades, relatively little action has been taken to address the opioid crisis. To mitigate the harm the opioid epidemic has caused in the United States, safe injection sites have emerged as a promising solution. Despite the exhaustive benefits of safe injection sites, including the reduction in the number of opioid overdose deaths, safe injection sites have faced opposition in the United States. Most of these concerns in the United States question the legality of safe injection sites, along with potential community implications. Through examining the ethics of safe injection sites from a Catholic social teaching perspective and performing an integrative literature review, safe injection sites are clearly ethical and would aid in respecting the dignity and life of people who inject drugs (PWID). With safe injection sites being ethical and recommendations in this paper to overcome concerns about safe injection sites, safe injection sites are a viable option to combat the opioid crisis in the United States.",book:{id:"10878",title:"Bioethical Issues in Healthcare",coverURL:"https://cdn.intechopen.com/books/images_new/10878.jpg"},signatures:"Peter A. Clark and David Grana"},{id:"80067",title:"The Risk of Inequality in Italian Healthcare Due to Covid-19",slug:"the-risk-of-inequality-in-italian-healthcare-due-to-covid-19",totalDownloads:63,totalDimensionsCites:0,doi:"10.5772/intechopen.97514",abstract:"The Italian National Health Service, characterized by the principles of universality, equality and fairness, has undergone changes over the years that have involved these essential characteristics. The decrease in financial resources was the first element that touched the Italian health organization. The spread of Covid-19 has attacked the balance of healthcare in Italy and put the equality of the entire care system at risk. The reform of the Italian health system, especially through the correct use of European financial resources, is the real test for the Italian health system of the future. It can be a moment of relaunch or the certification of a decline that jeopardizes constitutional rights.",book:{id:"10878",title:"Bioethical Issues in Healthcare",coverURL:"https://cdn.intechopen.com/books/images_new/10878.jpg"},signatures:"Carlo Ciardo"},{id:"79666",title:"Good Pharmacy Practice in India: Its Past, Present and Future with Need and Status in COVID 19",slug:"good-pharmacy-practice-in-india-its-past-present-and-future-with-need-and-status-in-covid-19",totalDownloads:150,totalDimensionsCites:0,doi:"10.5772/intechopen.100635",abstract:"The pandemic of COVID-19 has highlighted the importance of emergency preparedness and response (EP and R) in India’s education, training, capacity building, and infrastructure growth. Healthcare professionals, especially pharmacy professionals (PPs) in India, continued to provide drugs, supplies, and services during the pandemic. The public-private healthcare system in India is complicated and of varying quality. Patients face problems as a result of gaps in pharmacy practice education and training, as well as a lack of clarity about pharmacists’ positions. Job requirements and effective placement of healthcare professionals in patient care, as well as on (EP and R) task forces or policy representation, are complicated by this lack of distinction. We have also seen malpractice and spurious distribution in the healthcare and pharmaceutical domain in terms of personal protective kits, medications, injectable, life-saving oxygen, and other items during this unprecedented pandemic situation. A few of the incidents are as follows. The central division police in Bangalore (the Global BPO & IT Hub of India) booked a case of bed-blocking at a private hospital and arrested three people, one of whom is an Arogya Mitra (primary contact for the beneficiaries at every empaneled hospital care provider), for allegedly extorting ₹1.20 lakh from the son of a COVID-19 patient who later passed away. At least 178 COVID-19 patients in India have died because of oxygen shortage in recent weeks. Another 70 deaths have been attributed to an oxygen shortage by patients’ families, but this has been denied by the authorities. The Allahabad High court made a remark “Death of COVID patients due to non-supply of oxygen not less than genocide” on reports circulating on social media regarding the death of COVID-19 patients due to lack of oxygen in Lucknow and Meerut. A day ago, the Delhi police busted an industrial manufacturing unit in Uttarakhand’s Kotdwar where fake Remdesivir injections were being manufactured and arrested five people. These depict the ground reality and ethical standards of good pharmacy practice in this country. There is an utmost necessity to relook and re-establish the standards of pharmacy practice in healthcare setups available in each and every corner of the country in line with guidelines provided by the World Health Organization (WHO) and the International Pharmaceutical Federation (FIP). For that, the dependency and responsibilities are very high on healthcare professionals, particularly in this pandemic situation. The pharmacy zone is adaptable, evolving, and increasingly diverse, offering a wide range of work and management opportunities to execute. PPs are human service professionals whose responsibilities include safeguarding individuals by dispensing medications based on prescriptions. Representing the world’s third-largest medicinal services with active gathering, and in India, there are over 1,000,000 (1 million) enrolled PPs employed in various capacities and readily contributing to the country’s well-being. Pharmacy practice, which includes clinical, community, and hospital pharmacy, is referred to as total healthcare in its true sense. Through adaptation and implementation of GPP in healthcare setup, PPs form an essential link between physicians, nurses, and patients in the social community group, with an ultimate emphasis on patient well-being and protection. To instill quality and raise the standard in this chaotic situation there are strict measures required in the country. The International Pharmaceutical Federation and World Health Organization define good pharmacy practice (GPP) as practices that meet the personal needs of patients or those using pharmacy services by offering appropriate evidence-based care. In developed countries, pharmaceutical assistance is defined as a pharmaceutical practice model that involves attitudes, ethical values, behaviors, skills, appointments, and co-responsibility to prevent diseases, promote and recovery health in an integrated manner as part of the healthcare process, highlighting, among other, the requirement that the institution fully adopts the GPP. There is a need for a GPP Program designed by the Indian Govt. or its stakeholders in the context of the Indian healthcare system and adopting “new normal” due to the unprecedented event of COVID 19 and also raising the standard and importance of GPP for the healthcare professionals in the current scenario.",book:{id:"10878",title:"Bioethical Issues in Healthcare",coverURL:"https://cdn.intechopen.com/books/images_new/10878.jpg"},signatures:"Mrinmoy Roy"},{id:"79358",title:"Determination of Death: Ethical and Biomedical Update with International Consensus",slug:"determination-of-death-ethical-and-biomedical-update-with-international-consensus",totalDownloads:187,totalDimensionsCites:0,doi:"10.5772/intechopen.100604",abstract:"Humanity has been confronted with the concept and criteria of death for millennia and the line between life and death sustains to be debated. The profound change caused by life support technology and transplantation continues to challenge our notions of life and death. Despite scientific progress in the previous few decades, there remain big variations in diagnosis criteria applied in each country. Death is a process involving cessation of physiological function and determination of death is the final event in that process. Legally, a patient could be declared dead due to lack of brain function, and still may have a heartbeat when on a mechanical ventilator. Though there is no point in supporting ventilation in a dead person, withdrawing a ventilator before the legal criteria for death may involve the physician in both civil and criminal proceedings. To identify the moment of death is vital to avoid the use of unnecessary medical intervention on a patient who has already died and to ensure the organ donation process, clear and transparent. The age-old standard of determination of death is somatic standard and cardiopulmonary standard. Harvard report (1968) defines irreversible coma as a replacement criterion for death and prescribed clinical criteria for the permanently nonfunctioning brain. The current unifying concept of death: irreversible loss of the capacity for consciousness combined with irreversible loss of the capacity to breathe. WHO (2014) adopted minimum determinant death criteria, acceptable for medical practice globally, achieving international consensus on clinical criteria to maintain public trust and promote ethical practices that respect fundamental rights of individuals and minimize philosophical and biomedical debate in human death. AAN (2019) endorses that the brain death is the irreversible loss of all functions of the entire brain and equivalent to circulatory death.",book:{id:"10878",title:"Bioethical Issues in Healthcare",coverURL:"https://cdn.intechopen.com/books/images_new/10878.jpg"},signatures:"Md. Shah Alam Panna"},{id:"77450",title:"For a Model of Revision, Assistance and Care of Identities",slug:"for-a-model-of-revision-assistance-and-care-of-identities",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.98415",abstract:"The global crisis scenario has highlighted the weaknesses of advanced personal assistance and care systems, based on the absolute primacy of technical knowledge. Almost all health organizations have been challenged by the new Coronavirus. The universal system because it is realistically unable to reach everyone efficiently and effectively. The private model, albeit moderated by intentions of global care, because it is onerous and, in fact, not very inclusive. This study, without any pretense of completeness, thanks to an examination of the most well-known documents published by the organizations for the promotion of human health, both EU and international, highlights the essential aspects and purposes of some of the main models of health care, also identifying the critical issues and the remedies prepared. The main purpose of the text is to highlight and reflect on possible alternative solutions to the current strategies to combat the pandemic, implemented by the states. The probable contributing causes that have contributed to the spread of the new coronavirus and its variants globally and that have their roots in now dated issues are then analyzed. The lesson that the Pandemic teaches us is that “no one is saved alone” and that the problems of each family, social, national etc., represent the problems of everyone. The document concludes in the sense that, only through a new approach to individual and collective health care, marked by greater solidarity and respect for individual, specific identities and frailties, starting from those “hidden” in society (adolescents, elderly, of handicaps, immigrants, etc.) it will be possible to promote welfare systems that are more attentive to the needs imposed by the challenges of globalization and therefore really more effective, economical and efficient, and therefore more humane.",book:{id:"10878",title:"Bioethical Issues in Healthcare",coverURL:"https://cdn.intechopen.com/books/images_new/10878.jpg"},signatures:"Federico D’Angiolillo"},{id:"77679",title:"Compassion Versus Care in Healthcare Institutions: What’s the Difference?",slug:"compassion-versus-care-in-healthcare-institutions-what-s-the-difference",totalDownloads:97,totalDimensionsCites:0,doi:"10.5772/intechopen.97860",abstract:"In February 2013, the Francis Report outlined what it described as ‘systematic failings’ at Mid Staffordshire NHS Foundation Trust resulting in the death and suffering of many patients through neglect (in the UK context, hospitals can apply to gain foundation trust status. Foundation trust hospitals are part of the National Health Service (NHS) but are not directed by central government and have greater freedom to decide the way services are delivered. They adhere to core NHS principles of free medical treatment based on need and not the ability to pay.) A lack of compassion, particularly among nursing staff, was identified as one of the contributing factors to poor care. The NHS was founded on the core value of compassion that today is one of six values all NHS staff are expected to demonstrate. Frequently invoked as a means to ensuring good patient care, it is a concept that is contested by a number of writers who argue that such moral emotions are not only unnecessary but dangerous. The purpose of this work is to explore the difference between compassion and care (but not medical treatment) in the context of the NHS. The paper draws on the work of Anca Gheaus, who argues there is a distinction to be made between the two and that while it is possible to be compassionate towards everybody, the ability to care, is limited to fewer people and is a more intense and engaged activity. Regarded as the founding myth of the NHS, the work also draws on the parable of the Good Samaritan to make the distinction between the two concepts more visible, and argues the roles played by the Good Samaritan and the innkeeper, remain relevant to the workings of today’s healthcare system. It also reflects on the need for kindness within the system.",book:{id:"10878",title:"Bioethical Issues in Healthcare",coverURL:"https://cdn.intechopen.com/books/images_new/10878.jpg"},signatures:"Una P. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:31,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. 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\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation"},{id:"39",title:"Environmental Resilience and Management",scope:"
\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
\r\n\tWater is not only a crucial substance needed for biological life on Earth, but it is also a basic requirement for the existence and development of the human society. Owing to the importance of water to life on Earth, early researchers conducted numerous studies and analyses on the liquid form of water from the perspectives of chemistry, physics, earth science, and biology, and concluded that Earth is a "water polo". Water covers approximately 71% of Earth's surface. However, 97.2% of this water is seawater, 21.5% is icebergs and glaciers, and only 0.65% is freshwater that can be used directly by humans. As a result, the amount of water reserves available for human consumption is limited. The development, utilization, and protection of freshwater resources has become the focus of water science research for the continued improvement of human livelihoods and society.
\r\n
\r\n\tWater exists as solid, liquid, and gas within Earth’s atmosphere, lithosphere, and biosphere. Liquid water is used for a variety of purposes besides drinking, including power generation, ecology, landscaping, and shipping. Because water is involved in various environmental hydrological processes as well as numerous aspects of the economy and human society, the study of various phenomena in the hydrosphere, the laws governing their occurrence and development, the relationship between the hydrosphere and other spheres of Earth, and the relationship between water and social development, are all part of water science. Knowledge systems for water science are improving continuously. Water science has become a specialized field concerned with the identification of its physical, chemical, and biological properties. In addition, it reveals the laws of water distribution, movement, and circulation, and proposes methods and tools for water development, utilization, planning, management, and protection. Currently, the field of water science covers research related to topics such as hydrology, water resources and water environment. It also includes research on water related issues such as safety, engineering, economy, law, culture, information, and education.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",keywords:"Water, Water resources, Freshwater, Hydrological processes, Utilization, Protection"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 24th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:314,numberOfPublishedBooks:31,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/73635",hash:"",query:{},params:{id:"73635"},fullPath:"/chapters/73635",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()