Corrosion wear models.
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In a number of industries, in particular in the chemical industry, axial and radial turbomachines (compressors, superchargers, gas turbine installations, pumps) operate under aggressive environments, as a result of which rotor blades and disks are subject to corrosion wear.
Pipelines of hydropower are subject to corrosion wear, as a result of which their service life is significantly reduced. The problem of corrosion is especially acute in nuclear energy. Pipelines are made of low-alloy pearlite-grade carbon steel with stainless steel cladding on the inner surface. We also note that all parts and assemblies of the main circulation pumps in contact with the coolant, industrial cooling water, and locking water are made of special steels that are resistant to corrosion.
The coolant of the first circuit of a nuclear reactor is not just pure water, but water with boric acid dissolved in it (H3BO3), which contributes to significant corrosion of metal in pipelines. Steam generators of nuclear plants are made of pipes clad with anticorrosive austenitic surfacing.
It should be emphasized that the influence of the stress-strain state on the rate of corrosion and erosion wear also becomes important. For example, a strain of 1% increases the rate of corrosion of silicon iron in a 0.01% solution of sulfuric acid by 53% compared with undeformed metal [1].
Stress corrosion cracking of metals was previously studied. This phenomenon takes place at certain critical (threshold) values of tension determined by the acting stresses and potential energy. Stresses less than critical have an effect on general corrosion without causing cracking.
The impellers of radial and axial turbomachines subjected to corrosion are usually thin-walled plates and shells. The problem of the durability of the elements of the impellers of turbomachines is the problem of the durability of plates and shells of a variable thickness over time, under the influence of an aggressive environment that has certain parameters (degree of chemical activity, temperature, flow rate, etc.), and the stress-strain state.
One of the first works in this direction was an article by Kornishin [2], in which a joint solution of the corrosion equation is considered, which is a linear dependence of the corrosion rate on stress and equations describing the stress-strain state of a shell of variable thickness. The system of joint equations describing the behavior of the shell in a corrosive medium is then solved in finite differences according to a two-layer explicit scheme with a time step.
To date, there are a number of semi-empirical models that approximate corrosion wear taking into account the stress state. In Table 1, a number of models used in the calculations are given [3].
Corrosion wear models.
Table 1 indicates: h is the depth of the wear layer; t is the time; σ and ε are stress and strain; T is the temperature; k, α, β, and γ are constants; and φ (t) are some functions.
The issues of corrosion wear of centrifugal fan elements were investigated in a number of works by Pukhliy and Semenenko [1, 4, 5].
Bimetallic structures are widely used in modern technology, in particular, in the manufacture of bimetallic elements in nuclear energy. These are, first of all, bimetallic pipelines, bends, etc. These elements are characterized by high strength, heat resistance, and corrosion resistance.
The structural elements of nuclear power units operate under complex loading conditions, in particular, under conditions of exposure to aggressive environments. In this regard, the determination of the time to destruction of structural elements (resource) is the most important in the study of corrosion wear of elements that are in a complex stress-strain state [6, 7, 8].
In the present paper, an analytical approach to determining the resource of structural elements of nuclear power units based on the theory of bimetallic shells, taking into account the stress-strain state and corrosion wear of the elements, is presented.
Consider a cylindrical bimetallic shell when exposed to a corrosive environment [4]. Such tasks are very important in relation to the design of pipelines of nuclear power plants (corrosion cracking).
The rate of change of thickness at a given point in the shell is taken in the form:
with the initial condition:
where x, y are the normal coordinates of the middle surface of the shell; T is the temperature; and σ is the function connecting the rate of change of the shell thickness with the stress state at a surface point.
Note that F is a known function whose form is determined from experiment and
We study the effect of the stress state on general corrosion under the assumption that the corrosion rate is a linear function of the stress intensity.
The equations of corrosion wear are written as follows:
Here
It is necessary to add the equations of the theory of bimetallic shells to Eq. (1) or (3). As a result, we obtain an unrelated problem of the theory of shells, in view of which it is possible to apply a finite-difference approximation in time to the solution of Eq. (3).
Thus, the algorithm for solving the initial-boundary-value problem is reduced to the joint solution of Eq. (3) under the initial conditions in Eq. (2) and the system of equations for bimetallic shells, in the general case of variable thickness under the corresponding boundary conditions. Moreover, at each time step from Eq. (3), we obtain numerical values of the thickness of the structural element, which are then used to construct spline functions [9]. Then the system of equations of bimetallic shells is solved, from the solution of which the values of
The criterion for terminating the step-by-step process is the following condition:
where
The resource of structural elements of nuclear power units as a whole is determined by the summation of time steps.
We obtain the equilibrium equation of the bimetallic shell on the basis of the Lagrange variational principle:
Here
We write an expression for the variation of potential energy:
where
Integration extends to the entire surface of the junction (Figure 1): from
System of curvilinear coordinates on an undeformed junction surface.
In the analysis, the following assumptions are used (Figure 1).
The curvilinear coordinate system coincides with the lines of the main curvatures. This coordinate system is a Gaussian coordinate system, it is orthogonal.
The position of the point that does not belong to the junction surface determines the coordinates of the z-distance normal to the point from the junction surface (+ if it is directed along the internal normal to the junction surface).
The movement of u and v in are the direction of the tangents to
Deformations of the junction surface are determined by relative elongations
Eq. (5) can be represented as follows:
Denote by:
Then the variation of the potential of external forces is equal to:
Substituting Eqs. (6) and (7) in Eq. (4) we obtain:
Here
The last four terms in Eq. (8) is the work of concentrated forces along the edges of the shell
From Eq. (8), we obtain the equilibrium equation and boundary conditions.
In the mechanics of a solid deformable body, equilibrium equations can be obtained by making up for the main vector and the main moment of all the forces acting on the element for the infinitely small element extracted from the shell under the influence of external and internal forces (Figure 2). Here, the equilibrium equations and boundary conditions are obtained from the variational Lagrange principle in Eq. (4).
Internal forces acting on the edge of the element.
Note that in the case of dynamics, it is necessary to apply the variational Hamilton-Ostrogradsky principle.
So, from the first integral of expression in Eq. (8), the first three equations of equilibrium follow:
From the expressions in Eqs. (9)–(10), two more equations follow:
The sixth equation is an identity expressing the equality of the moments of all forces acting on the element to zero relative to the axis normal to the surface of the element junction:
This equation was used to obtain Eq. (11).
The second and third integrals of expression in Eq. (8) give boundary conditions for the edges
We emphasize that if one of the lines of the main curvatures is closed, then the displacements along this line will be periodic functions.
We introduce the following notation (Figure 3): R is the radius of the surface of the junction of a cylindrical bimetallic shell; l is the shell length;
Element of cylindrical shell.
Relative deformations of a surface located at a distance z from the junction surface (Figure 4):
Deformation of surface junction shell.
Normal stresses according to Hooke’s law:
Power factors:
Here:
Equations of an infinitesimal element:
The problem of axisymmetric deformation of an elastic bimetallic cylindrical shell for any relations between thicknesses, different mechanical characteristics of the material of the layers, and arbitrary heating along the thickness and axial direction is described by the equation:
Consider the case:
Then the force factors are written as follows:
Here
In this case, instead of Eq. (13), we obtain the following equation:
The boundary conditions for bimetallic shells coincide with similar conditions for homogeneous shells.
So, for a hard-pressed edge we get:
For the free edge we have:
We write the solution of the homogeneous Eq. (13) in the following form:
For an infinitely long shell in solution in Eq. (15),
Then:
Here
Example 1. Consider a bimetallic cylindrical shell under the influence of internal pressure q and a corrosive medium (Figure 5).
Geometry and loads acting on an element of two-layer shell: 1—outer layer; 2—inner layer;
In this case, the stress intensity is constant for all points of the shell and is equal to [5]:
Given Eq. (16), Eq. (3) takes the form:
with the initial condition:
The initial thickness
Eq. (17) with the initial condition Eq. (18) is integrated in quadratures:
In case
We note that Eq. (20) differs from linear equation
Let us determine the durability of a steel two-layer cylindrical shell with
Corrosion rate,
Given Eq. (3) we get:
The final value of the thickness of the shell
Substituting the values of the coefficients in Eq. (3), we find the durability T = 11.6 years. In conventional calculations, the durability is calculated by the formula:
In conclusion, it should be noted that in the general case it is necessary to solve the unrelated problem of the theory of shells [10, 11], when at each step of integration over time it is necessary to solve the problem of the stress-strain state of a bimetallic shell by a variable thickness, for which it is necessary to use methods of integrating partial equations derivatives [12, 13].
The impellers of centrifugal pumps subjected to corrosion are usually thin-walled plates and shells. The problem of the durability of the elements of the impellers of centrifugal pumps is the problem of the durability of the plates and shells of a variable thickness over time, under the influence of an aggressive environment with certain parameters (degree of chemical activity, temperature, flow rate, etc.), and the stress-strain state.
Figure 6 shows the layout of a centrifugal pump. Consider the durability of the working blades of centrifugal pumps, which are a trapezoidal shell of variable stiffness (Figure 7). The blade is subject to the combined action of centrifugal load and corrosion wear.
Scheme of centrifugal pump: 1—confuser; 2—impeller; 3—diffuser.
Geometry and coordinate system of centrifugal pump blade.
The rate of change of thickness at a given point of the blade is taken in the form of a functional relationship:
with the initial condition:
where x, y are the coordinates of the middle surface of the scapula; T is the temperature; and σ is the function connecting the rate of change of thickness with the stress state at a surface point. Function F should be determined from experiment.
Assuming that the rate of change in corrosion wear is a linear function of stress intensity, we write Eq. (21) in the form:
Eq. (23) must be supplemented with shell theory equations of variable thickness.
Omitting the intermediate calculations, we present a system of partial differential equations of the type Margherra [14] with respect to the normal deflection w and the stress function F of the eighth order, describing the stress state of the blade of variable thickness, taking into account the temperature effect:
Here T = T(x, y, z) is the temperature field of a general form; α is the coefficient of linear expansion of the material of the blade.
Power factors due to temperature exposure are recorded as:
We introduce the dimensionless coordinate system:
and dimensionless unknown functions
Here
The boundary conditions at the edges of the blade adjacent to the disks
The boundary conditions at the inlet and outlet edges of the blade correspond to the free edge. In this case we have:
The important issue is to specify the function of changing the blade thickness h = h (x, y) in the process of erosion-corrosion wear.
In our studies, the function of changing the blade thickness was set in the form of cubic splines [9].
In the general case, the blade thickness can be represented as two-dimensional spline interpolations:
This function on each element of the surface of the scapula
is a bicubic polynomial, continuous, and has continuous partial derivatives up to and including
We represent the system of Eq. (24) in a dimensionless form:
where
The analytical solution of the system of Eq. (31) with boundary conditions in Eq. (28) is based on the application of the method of integral relations by Dorodnitsyn [13].
In accordance with the method, we write the initial system of Eq. (31) in divergent form:
where
Through
In Eq. (32)
Following the method of integral relations of Dorodnitsyn [13], we look for a solution to the system of Eq. (32) in the form of an expansion:
As approximating and weighting functions, we choose the Jacobi system of orthogonal polynomials [15, 16] and their derivatives:
Here
Note that polynomials
We also emphasize that their derivatives
Restricting ourselves to the two-term approximation and also choosing power polynomials
It should be noted that in the general case there is no exact solution of such equations in mathematics, with the exception of individual special cases, for example, the Bessel equation.
Here, the modified method of successive approximations developed by Professor Pukhliy and published by him in the Academic Press [12, 17] is applied to the solution of the boundary-value problem.
Later, the method was extended to the solution of initial-boundary value problems [4], and to accelerate the convergence of the solution, the method of telescopic shift of the power series of K. Lanczos [18] was used. For this, we used the possibility of representing any power series in terms of shifted Chebyshev polynomials [15, 16]. For the first time, such an approach was presented in the works of V.A. Pukhliy [19, 20].
In accordance with the method, variable coefficients
Here
The general solution of the system of Eq. (34) has the form [10, 19, 20]:
where
The first approximation
Subsequent approximations are carried out according to the formulas:
The systems of fundamental functions in Eq. (37) are uniformly converging series, and the coefficients
The constants
Thus, the problem reduces to the joint solution of Eq. (23) and the system of Eq. (24) under initial conditions in Eq. (22) and boundary conditions in Eqs. (28) and (29). Moreover, at each time step, from Eq. (23) we obtain the numerical values of the thickness, which are used to construct spline functions in Eq. (30). Then the system of Eq. (24) is solved, from the solution of which the values
The criterion for terminating the step-by-step process is the condition:
where
The durability of the impeller element of centrifugal pumps is obtained by summing the steps in time.
The theory of corrosion wear of structural elements of hydropower and nuclear energy in the form of plates and shells is developed taking into account the stress state and corrosion wear.
Numerous factors affecting the speed of the corrosion wear process (degree of aggressiveness of the media, temperature, humidity, etc.) are taken into account in a generalized way by drawing up a differential equation for the rate of change of the thickness of the impeller element.
The criterion for the ultimate state of structural elements is the achievement by the structural element of the yield strength of the material
An algorithm has been developed for solving the problem of corrosion wear of bimetallic pipelines of nuclear energy, taking into account the stress-strain state of the elements.
An algorithm has been developed for the analytical solution of the problem of corrosion wear of rotor blades of centrifugal pumps based on a combination of the method of integral relations and the modified method of successive approximations in displaced Chebyshev polynomials.
Research has been funded by RFBR and City of Sevastopol under Research Project №18-48-920002.
Tumor necrosis factor (TNF) alpha is one of the first discovered cytokines shown by Carswell [1] in 1975 and was named for tumor regression activity induced in the serum of mice treated with
TNF-α is a potent mediator of inflammation, as well as many normal physiological functions in homeostasis and health and antimicrobial immunity [5]. Inflammation is a classical host defense response of vascularized living tissue to infection and injury, and in the central nervous system (CNS), the term neuroinflammation is used to denote cellular and inflammatory responses of vascularized neuronal tissue through activation of resident cells in the brain (microglia, astrocytes, and endothelial cells), the recruitment of blood-derived leukocytes including neutrophils, lymphocytes, and macrophages, and a plethora of humoral factors [6, 7]. More appropriately, neuroinflammation is a term used to denote inflammation associated with the brain and is characterized by the activation of microglia and expression of major inflammatory mediators without typical features of peripheral inflammation such as edema and neutrophil infiltration [8]. Neuroinflammation in the brain supposedly has a positive effect such as increasing blood flow and removal of damaged tissue by phagocytosis, but in a disease state, the resulting inappropriate inflammation caused negative effects which by far out weight the positive effect [6].
Nuclear factor kappa-light-chain enhancer of activated B cells (NFκB) otherwise called nuclear factor kappa B is a heterodimer and one of the most important transcription factors that activate transcription of many proinflammatory genes. It is well documented that TNF-α induces at least five different types of signals that include activation of NFκB, apoptosis pathways, extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (p38MAPK), and c-Jun N-terminal kinase (JNK) [2]. These biological functions of TNF-α makes its role in neuroinflammation critically prominent. It is therefore expedient to elucidate and expand the rational basis of TNF-α as major cytokine of neuroinflammation. Hence, this review discusses summary of literature on unique role of TNF-α in neuroinflammation and various agents that mediate neuroinflammation via TNF-α modulation.
Microglia being major immune cells involved in defense in the central nervous system, its activation is considered to be the hallmark of neuroinflammation [7, 9]. Activation of microglia cells constitutes the first key acute response in the brain to external aggression such as acute brain ischemia, traumatic brain injury, or microbial pathogen, and this microglial activation is coupled with subsequent activation of blood-borne monocytes/macrophages to yield a full-blown neuroinflammatory thick rim around ischemia infarct that becomes observable after 1 week in both human and animal models [10]. Microglia in the CNS constitutes 5–15% of total brain population; having share common precursor with peripheral macrophages, they produced transient inflammatory changes like macrophages such as phagocytosis, inflammatory cytokine production, and antigen presentation, normally returning to their basal state when the activation stimulus is resolved [11]. In a disease state such as in the onset of focal cerebral ischemia or traumatic brain injury, however, the microglia response becomes inappropriately more reactive and exaggerated to produce plethora of inflammatory mediators that trigger apoptosis and exaggerate neuronal damage [12]. Therefore, microglia/macrophages are the key immune cells concerned with the protection of brain against injury. Their architectural and functional changes are linked with the liberation of injury signals induced by pathology. These cells are usually responsible for clearance of demised neural cells and allow for restoration of lost neuronal functions. However, when markedly activated by the damage-associated molecular patterns subsequent to a disease state, they can generate a huge amount of proinflammatory cytokines that are capable of interrupting neural cells and the blood-brain barrier, and manipulate neurogenesis [9].
The primary function of microglia in the brain is to control any external aggression and neutralize its effect by a process of phagocytosis, which is a chronologically multistep system including oriented gradient motility (chemotaxis); identification of alien foreign agents by membrane lectins and receptors (recognition); encompassing flow round the injurious foreign agents into a vacuole/phagosome (engulfment); unraveling of intracellular secretor pools (granules); and liberation of innate antibiotics and enzymes into the phagosome, generation of reactive oxygen species by an intricate enzymatic system sequestrated on the phagocyte membrane and/or reactive nitrogen species by an inducible nitric oxide synthase, and decapitating and digestion of engulfed foreign substance in the multifaceted phagolysosomal medium (microbial killing) [13]. Therefore, there are four important events of phagocytosis: chemotaxis, recognition, engulfment, and microbial killing.
Chemotaxis is the immediate restricted, valuable host inflammatory reaction that is initiated by local tenant macrophages, demised cells and tissues, plasma factors, and microbial products. Specifically, the closely generated factors of inflammation (cytokines, activated complement protein, kinins, etc.) and microbial factors construct chemotactic gradients, alter endothelial cell membrane receptors, and encourage decrease of the blood flow. Blood-borne monocytes/macrophages that are rolling along the endothelial surface act in response to the chemotactic and cell-mediated signals and are primarily activated to definitely attach to the endothelium by way of their membrane integrins; the second pace is transendothelial migration, denoted as diapedesis, followed by tilting motility toward the inflammatory site (chemotaxis) [13].
Recognition involves identifying and attachment of particle to be ingested by the microglia/phagocytes. There are two methods of recognition: opsonin/opsonin dependent/receptor mediated and non-opsonin/opsonin independent. Opsonin/opsonin dependent is where microglia/phagocytes recognize pathogens via their membrane receptors for opsonins (e.g., complement factors C3b and iC3b and Fc component of immunoglobulins), which are present on the microbial surface, while non-opsonin/opsonin independent is where microglia/phagocytes recognize pathogens via microbial and phagocyte lectins [13]. Because microglia/phagocytes express high-affinity receptors for opsonin, the term opsonization is used to indicate a process, whereby injurious foreign particle becomes coated with substance, thereby enhancing its recognition by leukocyte and making it more open to phagocytosis. As aforementioned, the injurious foreign agents or microbes are usually opsonized by specific protein substances such as immunoglobulin G (IgG) antibodies, breakdown product of compliment (C3b), and fibrinogen all of which phagocytes express high-affinity receptors.
Engulfment refers to microglia/phagocyte extension of cytoplasm (pseudopods) flow around the injurious foreign agents or microbes after its binding with phagocyte and subsequent pinches off to form vesicles (phagosome) that enclose the injurious foreign agents or microbes. Phagocyte extensions (pseudopods) finally engulf the injurious foreign agent or microbe in a vacuole and trigger the activation of two functions: the release of granule contents into the phagosome and the oxidative burst. Coiling engulfment is the most frequent unusual uptake: unilateral pseudopods wrap around the microorganism in multiple turns, giving rise to largely self-apposed pseudopodial surfaces [13].
Microbial killing can be achieved through oxygen-dependent or oxygen-independent/non-oxygen-dependent method of pathogen or injurious agent killing. Oxygen dependent involves the use free radicals. A free radical is clearly referred to as atom or molecule having one or more unpaired electrons in valence shell or outer orbit and is competent for autonomous survival [14]. The strange quantities of odd electron(s) possess by a free radical make it unbalanced, short lived, and extremely reactive. This high reactivity makes free radical exert a pull on electrons from further compounds to reach steadiness. The newly pulled attacked molecule loses its electron and becomes a free radical itself, opening a chain of feedback cascade of reaction. Free radicals/oxidants derived from both endogenous sources and exogenous sources have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. They include reactive oxygen species (ROS) which are hydroxyl radicals (˙OH), superoxide (O2−), hydrogen peroxide (H2O2), and reactive nitrogen species (RNS) which are nitric oxide (NO) and peroxynitrite (OONO−). At reasonable or little concentrations, ROS/RNS encompasses desirable effects and engage in a variety of physiological purposes such as in immune function (i.e., guard in opposition to pathogenic microorganisms), in certain cellular signaling pathways, in mitogenic reaction, and in redox directive. Conversely, at excessively elevated concentrations, both ROS and RNS lead to oxidative stress and nitrosative stress, respectively, that potentially cause adverse effect to biological molecules [14].
The mechanism of oxygen-dependent microbial killing is initiated after engulfment where oxygen burst is activated to cause increase in oxygen consumption (50- to 100-fold increase) and metabolism; this leads to massive production of nicotinamide adenosine diphosphate (NADP) as by-product of adenosine triphosphate (ATP) generation by oxidative phosphorylation. The oxygen burst is unrelated to mitochondrial respiration and reflects the activity of the NADPH oxidase system in the cytosol and membrane constituents, which are separated in resting microglia/phagocytes and are reassembled upon microglia/phagocytes activation. The generated NADP through NADPH oxidase enzyme activity generates superoxide (O2−) which is further converted to hydrogen peroxide (H2O2) either spontaneously or through enzymatic catalysis of superoxide dismutase (SOD) enzyme by combining with hydrogen ion (H+). Both hydrogen peroxide (H2O2) and superoxide (O2−) can cause microbial killing. For instance, H2O2 in the presence of myeloperoxidase (MPO) released from microglia/phagocytes azurophilic (primary) granules and a halide generates very potent oxidizing agents such as hypochlorous acid (HOCl) and chloramines [13]. Other oxidative species such as singlet oxygen has been suggested to be important for microbial killing through the formation of ozone [15].
Non-oxygen-dependent/oxygen-independent microbial killing is mediated by protein molecule and other factors that are mostly found within the lysosome such as lysozyme, lactoferrin, and elastase. Lysozyme is an enzyme that hydrolyzes N-acetyl glucosamine bond found in glycopeptide coat of all bacterial cell wall. Thus, non-oxygen-dependent/oxygen-independent microbial killing is dependent on protein and peptide antibiotics such as bactericidal permeability-increasing protein, cationic antimicrobial protein 37, and defensins that are stored in peroxidase-positive (azurophilic, primary) granules where they are together localize with active proteases such as elastase, cathepsin G, and proteinase 3. The synergistic interaction of oxygen-dependent and non-oxygen-dependent/oxygen-independent microbial killing systems generally results in pathogen killing [13].
Pathological consequences that result from a disease state of the brain, however, make microglia response becomes inappropriately exaggerated. Microglia when transformed into phagocytes can release a variety of substances many of which are cytotoxic and/or cytoprotective. While cytoprotective substances include neurotrophic molecules such as brain-derived neurotrophic factor (BDNF), insulin-like growth factor I (IGF-I), several other growth factors, and anti-inflammatory factors, cytotoxic substances include proinflammatory cytokines such as TNF-α, IL-1β, and IL-6 as well as other potential cytotoxic molecules including nitric oxide (NO), reactive oxygen species (ROS), and prostanoids. The uniquely outburst cytokines extensively studied in acute ischemic stroke are tumor necrosis factor-α (TNF-α); the interleukins (IL), IL-1β, IL-6, IL-20, and IL-10; and transforming growth factor (TGF)-β. Although IL-1β and TNF-α are proinflammatory that appears to exacerbate cerebral injury, TGF-β and IL-10 are anti-inflammatory that may exert neuroprotective effects, and IL-6 has both pro- and anti-inflammatory effects [16]. Astrocytes, like microglia, are also capable of secreting inflammatory factors such as cytokines, chemotaxis cytokines (chemokines), and NO in response to brain pathological state.
Table 1 reveals researches of various agents that mediate neuroinflammation via TNF modulation.
Treatment | Experimental model | Related TNF finding | References |
---|---|---|---|
Puerarin | Stroke model of rat middle cerebral artery occlusion | Modulate neuroinflammation by mark reduction in mRNA expression of tumor necrosis factor-α (TNF-α) | [17] |
Edaravone and scutellarin | Stroke model of rat intraluminal middle cerebral artery occlusion | Modulate neuroinflammation by attenuating expression levels of TNF-α | [18] |
Matrix metalloproteinase-8 inhibitor (M8I) | Stroke model of rat middle cerebral artery occlusion | Modulate neuroinflammation by abrogating TNF-α expression | [19] |
Wogonin (5,7-dihydroxy-8-methoxyflavone) | Stroke model of rat middle cerebral artery occlusion | Modulate neuroinflammation by decrease in production of TNF-α | [20] |
Nicotine | Stroke model of rat global cerebral ischemia | Modulate neuroinflammation by significant reduction of enhanced expression of tumor necrosis factor alpha (TNF-α) | [21] |
Glycyrrhizin (GRZ) | Brain cognitive impairment and neuroinflammation of lipopolysaccharide treated Mice | Modulate neuroinflammation through inhibition of proinflammatory TNF-α | [8] |
Atorvastatin | Stroke model of rat intracerebral hemorrhage | Modulate neuroinflammation by dose-dependent reduction of TNF-α | [22] |
Angiotensin-(1–7) | Stroke model of mice intracerebral hemorrhage | Modulate neuroinflammation by decrease in levels of TNF-α | [23] |
Milk fat globule-EGF factor VIII (MFG-E8) | Stroke model of rat permanent middle cerebral artery occlusion | Modulate neuroinflammation through decrease in expression of cerebral TNF-α level | [24] |
Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol) | Stroke model of mice transient middle cerebral artery occlusion | Modulate neuroinflammation through inhibition of lipopolysaccharide-induced production of TNF-α | [25] |
Kaempferol glycosides | Stroke model of rat transient middle cerebral artery occlusion | Modulate neuroinflammation by inhibiting expression of tumor necrosis factor alpha | [26] |
Angiotensin-(1–7) | Stroke model of rat permanent middle cerebral artery occlusion | Modulate neuroinflammation by inhibiting increase in TNF-α | [27] |
Nicotine | Stroke model of rat global ischemia | Modulate neuroinflammation by reduction of enhanced expression of tumor necrosis factor alpha (TNF-α) induced by ischemia/reperfusion | [21] |
Propofol | Brain neuroinflammation of lipopolysaccharide-induced inflammation in activated microglia | Modulate neuroinflammation by inhibiting lipopolysaccharide-mediated production TNF-α | [28] |
Zileuton | Stroke model of rat permanent middle cerebral artery occlusion | Modulate neuroinflammation through attenuating release of TNF-α in the serum | [29] |
Caffeic acid ester fraction (Caf) | Stroke model of rat middle cerebral artery occlusion in vivo and lipopolysaccharide-induced microglial activation in vitro | Modulate neuroinflammation by inhibiting TNF-α induced by lipopolysaccharide treatment in primary microglia in a dose-dependent manner | [30] |
Telmisartan | Stroke model of rat intracerebral hemorrhage | Modulate neuroinflammation by decrease in tumor necrosis factor-α | [31] |
Setarud (IMOD™) | Human patients with acute ischemic stroke | Modulate neuroinflammation by decrease in TNF-α levels | [32] |
Caffeine | Brain neuroinflammation of lipopolysaccharide (LPS)-stimulated murine BV2 microglial cells | Modulate neuroinflammation by suppressing generation of proinflammatory TNF-α | [33] |
SCH58261 | Stroke model of rat bilateral common carotid artery occlusion | Modulate neuroinflammation by reversing ischemia reperfusion injury induced elevation of TNF-α. | [34] |
Caffeine | Stroke model of rat bilateral common carotid artery occlusion | Modulate neuroinflammation by reduction of TNF-α activity | [35] |
Fluoxetine | Stroke model of rat subarachnoid hemorrhage | Modulate neuroinflammation by decreasing the expression of proinflammatory mRNA levels of TNF-α | [36] |
Matrix metalloproteinases 8 (MMP-8) inhibitor | Brain neuroinflammation of lipoteichoic acid (LTA)-stimulated rat primary astrocytes | Modulate neuroinflammation by inhibiting lipoteichoic acid (LTA) induced expression of TNF-α | [37] |
Sildenafil | Brain neuroinflammation and demyelination induced by cuprizone in Mice model of multiple sclerosis. | Modulate neuroinflammation by reduction in the expression of the proinflammatory cytokines TNF-α | [38] |
Various agents that mediate neuroinflammation via TNF modulation.
In a comprehensive review of agents that induce neuroinflammation, Nazeem [39] has classified models of neuroinflammation based on mechanism through which agents induce neuroinflammation into three as follows:
The most commonly studied model of neuroinflammation is LPS-induced neuroinflammation which activates microglia in the brain [40]. LPS also termed endotoxin is a constituent of the external membrane of Gram-negative bacteria, and the mechanism of LPS-induced neuroinflammation is mediated through LPS binding with CD14 on microglia membranes. The LPS-CD14 complex then interacts with the Toll-like receptor-4 (TLR-4), which, in turn, activates microglia by initiating signal transduction cascades leading to rapid transcription and release of proinflammatory cytokines, chemokines, and the complement system proteins, as well as anti-inflammatory cytokines like IL-10 and transforming growth factor-β (TGF-β) [39].
Another popular emerging noninvasive, effective, and sterile method of induction neuroinflammation in animal model is MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of contrast agent microbubbles (MB). This MRI-guided pFUS+MB has advantage over all other methods of inducing neuroinflammation in a way that it induces neuroinflammation without systemic involvement [40].
Within the brain, TNF-α is produced and discharged in the brain predominantly by glial cells and neurons, with microglia and astrocytes being the major glial cells involved. Upon arrival of appropriate TNF-α production stimulus, TNF-α is formed as a 27-kDa (233 amino acids) precursor, which binds to cell membrane of producing cells. This precursor is cleaved by proteolysis to liberate a 17-kDa (157 amino acids) subunit by the action of TNF alpha-converting enzyme (TACE). TACE also known as ADAM17 is well-identified proteinase enzyme that mediates the process TNF-α production and is a member in the family of mammalian adamalysins (or ADAMs: A disintegrins and metalloproteinases) [41].
Upon cleavage by TACE/ADAM17, the free TNF-α forms a bioactive homotrimer that lead to biological effect of TNF-α. The actions of TNF-α is achieved through two distinct cell surface receptors: TNFR1 and TNFR2. TNF-α generates the activation of TNF receptors (TNFR1 and TNFR2), and the resultant TNF-induced TNFR signaling pathways are complex and wide ranging in different cell types, and precise circumstances, thereby accounting for TNF-α pleiotropic nature of action [5]. For instance, with TNFR1 signaling pathway, binding of TNF-α to the cognate receptor leads to the recruitment of TNF-α adaptor protein termed as TNF receptor-associated death domain (TRADD), which then creates a platform for binding of additional cytoplasmic adaptor proteins including TNF receptor-associated factor 2 (TRAF2), receptor-interacting protein (RIP), and FAS-associated death domain (FADD). The TRAF2 and RIP are concerned in escalating the transcriptional gene regulation; TRAF2 triggers the activation of a mitogen-activated protein kinase (MAPK) pathway, thereby leading to the activation of c-Jun N-terminal kinase (JNK), thus increasing its transcriptional activity; the RIP is a protein kinase vital to the activation of the transcription factor NFκB by phosphorylation of IκB kinase (IKK). On the other hand, FADD pathway leads to activation of caspase-8, thereby leading to initiate a caspase cascade of apoptosis cellular demise [41]. Although TNF-α binds to both TNFR1 and TNFR2 receptors with high affinity, there are some species specificity in terms of the receptor subtype and TNF-α binding [42]. TNF-α-induced p38 MAPK pathway transcription activity has been also implicated to induce proinflammatory IL-6 synthesis [43].
Neuroinflammation involves activation of microglia and astrocytes as well as influx of hematogenous cells recruited by cytokines, adhesion molecules, and chemokines across the activated blood vessel wall [44]. Neuroinflammatory signaling involves a coordinated effort of different molecules and cells types and is largely coordinated by a ubiquitous transcription factor NFκB. This signal transduction pathway for the activation of the transcription factor NFκB leads to control the expression of numerous genes activated during inflammation (i.e., cytokines, chemokines, growth factors, immune receptors, cellular ligands, and adhesion molecules). Thus, NFκB regulates a number of genes (including those coding for key inflammatory cytokines, like IL-6, TNF-α, etc.) involved in inflammation, making it the most important transcription factor that plays a key role in the inflammatory response. The collective gene targets of NFκB include various adhesion molecules, cytokines and chemokines (involved in proinflammatory signaling and NFκB activation, e.g., IL-1β and TNF-α), metalloproteinases (e.g., MMP-9), immune receptors, acute phase proteins, cell surface receptors, and inflammatory enzymes [45]. Various stimuli, such as cytokines, viruses, and oxidants, result in the activation of the transcription factor NFκB by separating it from inhibitor of NFκB alpha (IκBα)-bound protein in the cytoplasm, which becomes degraded and allows NFκB to move to the nucleus, where it binds to the DNA of the genes for numerous inflammatory mediators, resulting in their increased production and secretion [46].
It is pertinent to note that neuroinflammatory microglia-/macrophage-mediated phagocytosis is instrumental in neutralizing injurious foreign agent and conducting brain cleanup, the process which must occur to allow for tissue repair and functional recovery. This fast and efficient removal of apoptotic, dislocated, and damaged cells, before the discharge of injurious and proinflammatory cell contents occur, may help to reduce secondary damage. But inappropriate inflammatory responses generated by microglia/macrophages in a disease state may aggravate brain injury [45].
Proinflammatory TNF-α being one of the most key important early initiators of neuroinflammation interacts with two receptors R1 and R2, to mediate extrinsic apoptotic death signal via Fas-associated death domain (FADD) and inflammation via nuclear factor kappa-light-chain enhancer of activated B cells (NFĸB), respectively [5]. NFκB is a major regulatory transcription factor with a pivotal role in inducing genes involved in inflammation [47]. In its dormant state, NFκB resides in the cytosol where it is bound to its inhibitory proteins known as inhibitors of NFκB (IκB), most commonly inhibitor of NFκB alpha (IκBα), making it unable to translocate into the nucleus [48]. Inflammatory stimuli resulting from wide range of brain pathological processes, such as cerebral ischemia, leads to degradation of these inhibitors upon their phosphorylation by the IκB kinase (IKK), which allows NFκB to migrate into the nucleus, where it binds with DNA, and activates transcription of many proinflammatory genes [49]. This includes increase in expression of the genes for proinflammatory cytokines, chemokines, enzymes that generate mediators of inflammation, and adhesion molecules [50]. Thus, TNF-α both activate and are activated by NFκB, creating a type positive regulatory loop that amplify and perpetuate local inflammation [50]. Hence, these pathways of TNF-α-induced NF-kB explain the ability of TNF-α to induce other inflammatory cytokines such as IL-6 and IL-8 and synergize with interferons [5].
Apart from IκB-NFκB pathway, another intracellular signaling pathway through which TNF-α induces other inflammatory cytokines is Janus family of tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. This JAK-STAT pathway can be initiated when there is TNF-α signaling after binding to its cognate receptors and consequently stimulates STATs. The STATs subsequently become activated and translocate to the nucleus to transmit transcriptional genetic expression of many cytokines, thereby leading to their synthesis [43].
Therefore, TNF-α is a proinflammatory cytokine that plays a critical role under both homeostatic and pathophysiological status within the central nervous system. Under healthy status, TNF-α has regulatory functions on vital physiological processes such as synaptic plasticity, learning and memory, sleep, food and water intake, and astrocyte-mediated synaptic amplification [51]. Under pathological status, astrocytes and mainly microglia excessively release massive concentration of TNF-α, thereby leading important constituent of neuroinflammatory response that marks a characteristic of several neurological disorders. Neuroinflammation itself at the first initial stage is a protective response in the brain, but excessively inappropriate inflammatory responses are detrimental, and in fact, it diminish the neuronal regeneration thereby leading to neurodegenerative diseases and other neurological disorders [52, 53].
Microglia is a pivotal brain endogenous protective mechanism against various injuries agents. If such an injury is tolerable, it triggers cellular responses that protect the brain and precondition the body against more severe stimuli. Beyond tolerable level, it triggers response that may potentially aggravate brain injury. TNF-α is released by microglia-induced NFκB activation, and activated NFκB in turn activates more TNF-α. The IκB-NFκB pathway together with other intracellular signaling pathway such as p38 MAPK pathway and JAK-STAT pathway that all orchestrate cascade of cytokine production makes TNF-α so-called master regulator of neuroinflammatory cytokine production. This phenomenon forms the basis of TNF-α as major cytokine of brain neuroinflammation.
The author declares no conflict of interest.
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The existing variety of proposed approaches is classified in accordance with the “big five rules” for these assays, including proper sample, receptor, interaction, response, and output. The solutions for rapid extraction of target analytes and preventing negative influence of extractants are considered. Role to antibodies affinity and specificity is characterized. Potential of alternate bioreceptor molecules is discussed. Immunoreactants’ compositions, concentrations, and locations on the test strip are characterized as factors determining assay parameters. The existing variety of labels is compared in terms of their optical and alternate registration. Tools to modulate a sequence of analytical reactions and to form aggregates of the detected labels are considered. The discussed approaches are illustrated through developments of test strips for detection of mycotoxins, veterinary drugs, and other analytes.",book:{id:"6470",slug:"rapid-test-advances-in-design-format-and-diagnostic-applications",title:"Rapid Test",fullTitle:"Rapid Test - Advances in Design, Format and Diagnostic Applications"},signatures:"Anatoly V. Zherdev and Boris B. Dzantiev",authors:[{id:"175229",title:"Dr.",name:"Anatoly",middleName:null,surname:"Zherdev",slug:"anatoly-zherdev",fullName:"Anatoly Zherdev"},{id:"224281",title:"Prof.",name:"Boris",middleName:"B",surname:"Dzantiev",slug:"boris-dzantiev",fullName:"Boris Dzantiev"}]},{id:"33156",doi:"10.5772/38038",title:"Serology Applied to Plant Virology",slug:"serology-applied-to-plant-virology",totalDownloads:4265,totalCrossrefCites:6,totalDimensionsCites:17,abstract:null,book:{id:"1697",slug:"serological-diagnosis-of-certain-human-animal-and-plant-diseases",title:"Serological Diagnosis of Certain Human, Animal and Plant Diseases",fullTitle:"Serological Diagnosis of Certain Human, Animal and Plant Diseases"},signatures:"J. Albersio A. Lima, Aline Kelly Q. Nascimento, Paula Radaelli and Dan E. Purcifull",authors:[{id:"115306",title:"Dr.",name:"Jose Albersio A.",middleName:"Araujo",surname:"Lima",slug:"jose-albersio-a.-lima",fullName:"Jose Albersio A. 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Nascimento"},{id:"137876",title:"Dr.",name:"Dan",middleName:null,surname:"Purcifull",slug:"dan-purcifull",fullName:"Dan Purcifull"},{id:"137877",title:"Dr.",name:"Radaelli",middleName:null,surname:"Paula",slug:"radaelli-paula",fullName:"Radaelli Paula"}]},{id:"33154",doi:"10.5772/36464",title:"Serodiagnosis of Peste des Petits Ruminants Virus",slug:"serodiagnosis-of-peste-des-petits-ruminants-virus",totalDownloads:4460,totalCrossrefCites:6,totalDimensionsCites:8,abstract:null,book:{id:"1697",slug:"serological-diagnosis-of-certain-human-animal-and-plant-diseases",title:"Serological Diagnosis of Certain Human, Animal and Plant Diseases",fullTitle:"Serological Diagnosis of Certain Human, Animal and Plant Diseases"},signatures:"Muhammad Munir, Muhammad Abubakar, Siamak Zohari and Mikael Berg",authors:[{id:"108444",title:"Dr.",name:"Muhammad",middleName:null,surname:"Munir",slug:"muhammad-munir",fullName:"Muhammad Munir"},{id:"113339",title:"Dr.",name:"Muhammad",middleName:null,surname:"Abubakar",slug:"muhammad-abubakar",fullName:"Muhammad Abubakar"},{id:"113341",title:"Dr.",name:"Siamak",middleName:null,surname:"Zohari",slug:"siamak-zohari",fullName:"Siamak Zohari"},{id:"113342",title:"Prof.",name:"Mikael",middleName:null,surname:"Berg",slug:"mikael-berg",fullName:"Mikael Berg"}]}],mostDownloadedChaptersLast30Days:[{id:"61451",title:"Ways to Reach Lower Detection Limits of Lateral Flow Immunoassays",slug:"ways-to-reach-lower-detection-limits-of-lateral-flow-immunoassays",totalDownloads:2751,totalCrossrefCites:11,totalDimensionsCites:24,abstract:"This chapter considers factors influencing sensitivity of lateral flow immunoassay and modern developments that are focused on reaching lower detection limits. The existing variety of proposed approaches is classified in accordance with the “big five rules” for these assays, including proper sample, receptor, interaction, response, and output. The solutions for rapid extraction of target analytes and preventing negative influence of extractants are considered. Role to antibodies affinity and specificity is characterized. Potential of alternate bioreceptor molecules is discussed. Immunoreactants’ compositions, concentrations, and locations on the test strip are characterized as factors determining assay parameters. The existing variety of labels is compared in terms of their optical and alternate registration. Tools to modulate a sequence of analytical reactions and to form aggregates of the detected labels are considered. The discussed approaches are illustrated through developments of test strips for detection of mycotoxins, veterinary drugs, and other analytes.",book:{id:"6470",slug:"rapid-test-advances-in-design-format-and-diagnostic-applications",title:"Rapid Test",fullTitle:"Rapid Test - Advances in Design, Format and Diagnostic Applications"},signatures:"Anatoly V. Zherdev and Boris B. Dzantiev",authors:[{id:"175229",title:"Dr.",name:"Anatoly",middleName:null,surname:"Zherdev",slug:"anatoly-zherdev",fullName:"Anatoly Zherdev"},{id:"224281",title:"Prof.",name:"Boris",middleName:"B",surname:"Dzantiev",slug:"boris-dzantiev",fullName:"Boris Dzantiev"}]},{id:"60908",title:"Microarrays as Platform for Multiplex Assays in Biomarker and Drug Discovery",slug:"microarrays-as-platform-for-multiplex-assays-in-biomarker-and-drug-discovery",totalDownloads:1126,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Despite the tremendous advances in the understanding of the molecular mechanisms and the complexity of the diseases is one of the present challenges for the scientific community; then, novel strategies are required to be designed and developed for effective strategies for early diagnosis and treatment. As many cellular alterations are observed at protein level, high-throughput assays are dramatically needed for biomarker discovery. Herein, we describe advantages and limitations of protein microarrays, as proteomics strategy useful for multiplex and high-throughput protein characterization in clinical samples. Finally, a few examples are discussed; mostly of them related to currently disease biomarkers already identified in proximal fluids by protein arrays are discussed.",book:{id:"6470",slug:"rapid-test-advances-in-design-format-and-diagnostic-applications",title:"Rapid Test",fullTitle:"Rapid Test - Advances in Design, Format and Diagnostic Applications"},signatures:"Pablo Juanes-Velasco, Javier Carabias-Sanchez, Rodrigo Garcia-\nValiente, Jonatan Fernandez-García, Rafael Gongora, Maria\nGonzalez-Gonzalez and Manuel Fuentes",authors:[{id:"173804",title:"Dr.",name:"Manuel",middleName:null,surname:"Fuentes",slug:"manuel-fuentes",fullName:"Manuel Fuentes"}]},{id:"33740",title:"Interferences in Immunoassays",slug:"interference-in-immunoassays",totalDownloads:17492,totalCrossrefCites:14,totalDimensionsCites:53,abstract:null,book:{id:"1499",slug:"advances-in-immunoassay-technology",title:"Advances in Immunoassay Technology",fullTitle:"Advances in Immunoassay Technology"},signatures:"Johan Schiettecatte, Ellen Anckaert and Johan Smitz",authors:[{id:"105883",title:"Mr.",name:"Johan",middleName:null,surname:"Schiettecatte",slug:"johan-schiettecatte",fullName:"Johan Schiettecatte"},{id:"113099",title:"Dr.",name:"Ellen",middleName:null,surname:"Anckaert",slug:"ellen-anckaert",fullName:"Ellen Anckaert"},{id:"113100",title:"Prof.",name:"Johan",middleName:null,surname:"Smitz",slug:"johan-smitz",fullName:"Johan Smitz"}]},{id:"61519",title:"SLE, An Overlooked Disease: Possibilities for Early Rescue by Early Diagnosis",slug:"sle-an-overlooked-disease-possibilities-for-early-rescue-by-early-diagnosis",totalDownloads:1200,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Systemic lupus erythematosus (SLE) is a progressive autoimmune disease associated with widespread organ damage that can eventually cause death. Worldwide prevalence of SLE is difficult to report mainly due to difficulty in diagnosis as a result of its heterogeneous nature and nonspecific protean manifestations. Currently, circulating anti-DNA antibodies are the most specific diagnostic biomarkers for SLE where many detection assays are being employed in clinical practice. However, the diagnostic value of these techniques is challenged by the detection of only subpopulations of these antibodies with varying sensitivity and specificity. This is mainly attributed to differences in the antigen source and presentation and in the employed reaction conditions. This chapter will thoroughly discuss the technology, advantages, and limitations of each assay in addition to a special focus on the recently developed diagnostic technologies and novel biomarkers. Moreover, SLE will be presented as a disease model highlighting the importance of personalized medicine.",book:{id:"6470",slug:"rapid-test-advances-in-design-format-and-diagnostic-applications",title:"Rapid Test",fullTitle:"Rapid Test - Advances in Design, Format and Diagnostic Applications"},signatures:"Reem K. Arafa and Mariam M. Ahmed",authors:[{id:"231130",title:"Prof.",name:"Reem",middleName:null,surname:"Arafa",slug:"reem-arafa",fullName:"Reem Arafa"},{id:"231133",title:"MSc.",name:"Mariam",middleName:null,surname:"Magdy",slug:"mariam-magdy",fullName:"Mariam Magdy"}]},{id:"33151",title:"Helicobacter pylori Infection and Undiagnosed Dyspepsia in Dyspeptic Populations Under 45 of Age Tested by ELISA, Urease Breath Test and Helicotest",slug:"the-level-of-elisa-antibody-and-h-pylori-infection",totalDownloads:3314,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"1697",slug:"serological-diagnosis-of-certain-human-animal-and-plant-diseases",title:"Serological Diagnosis of Certain Human, Animal and Plant Diseases",fullTitle:"Serological Diagnosis of Certain Human, Animal and Plant Diseases"},signatures:"Małgorzata Palka",authors:[{id:"110466",title:"Dr.",name:"Margaret",middleName:null,surname:"Palka",slug:"margaret-palka",fullName:"Margaret Palka"}]}],onlineFirstChaptersFilter:{topicId:"902",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:290,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"93",type:"subseries",title:"Inclusivity and Social Equity",keywords:"Social contract, SDG, Human rights, Inclusiveness, Equity, Democracy, Personal learning, Collaboration, Glocalization",scope:"\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems.
\r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
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",annualVolume:11967,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},{id:"40",title:"Ecosystems and Biodiversity",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation",scope:"