Numerical comparison of NM, DUSM, and SM.
\r\n\t(1) Sustainable Waste Management;
\r\n\t(2) Micro(nano)plastics in the Environments;
\r\n\t(3) Electronic Waste and Circular Economy;
\r\n\t(4) Reducing, Recycling and Recovery of Agricultural and Food Waste;
\r\n\t(5) Biomass Valorization: Waste to Resources;
\r\n\t(6) Governmental Policy on Waste Management and Valorization.
\r\n\tThis book will offer a timely opportunity for knowledge exchange of sustainable management agenda for biological waste and remediation of soil, water and air in the local context, which satisfies the environmental compatibility, financial feasibility and social needs. It will deliberate on state-of-the-art treatment technologies, advanced management strategies, and political issues pertaining to recycling and recovery of organic waste.
",isbn:"978-1-80355-913-1",printIsbn:"978-1-80355-912-4",pdfIsbn:"978-1-80355-914-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"4ef7ac85e87a3131afb9b858b79aa870",bookSignature:"Associate Prof. Tao Zhang",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11256.jpg",keywords:"Waste Management, Microplastics, Nanoplastics, Electronic Waste, Agricultural Waste, Food Waste, Recycling, Recovery, Biomass, Resources, Governmental Policy, Environmental Protection",numberOfDownloads:64,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 10th 2021",dateEndSecondStepPublish:"December 8th 2021",dateEndThirdStepPublish:"February 6th 2022",dateEndFourthStepPublish:"April 27th 2022",dateEndFifthStepPublish:"June 26th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"7 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:'Dr. Zhang was a visiting scholar at Arizona State University in 2014 and at the University of Hohenheim in 2017. He is the director of the Circular Economy Committee of the Chinese Society for Environmental Sciences and Water Treatment and Recycling Committee of the Chinese Society for Environmental Sciences. He has been authorized 17 invention patents in China and has won the Chinese prize for the "Outstanding Young Scientist” in 2019.',coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"185487",title:"Associate Prof.",name:"Tao",middleName:null,surname:"Zhang",slug:"tao-zhang",fullName:"Tao Zhang",profilePictureURL:"https://mts.intechopen.com/storage/users/185487/images/system/185487.jpg",biography:"Dr. Tao Zhang is an Associate Professor and Ph.D. Supervisor at the College of Resources and Environmental Sciences, China Agricultural University, China. His academic background covers waste management, wastewater treatment, utilization of agricultural waste. He is awarded the Scientific Chinese - Outstanding Young Scientist Award, the Innovation Award for Industry-University-Research Cooperation of China, the Character Award - Invention and Entrepreneurship Award of China Association of Inventions. His H-index is 23 (Scopus) and he has published more than 50 papers in Chemical Engineering Journal, Water Research, Journal of Hazardous Materials, Green Chemistry, Renewable and Sustainable Energy Reviews, and so on. Amongst, 11 ESI Highly Cited Paper and 4 ESI Hot Paper. He has authorized more than 20 Chinese invention patents.",institutionString:"China Agricultural University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"China Agricultural University",institutionURL:null,country:{name:"China"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"7",title:"Business, Management and Economics",slug:"business-management-and-economics"}],chapters:[{id:"81303",title:"The Role of Biochar Systems in the Circular Economy: Biomass Waste Valorization and Soil Remediation",slug:"the-role-of-biochar-systems-in-the-circular-economy-biomass-waste-valorization-and-soil-remediation",totalDownloads:34,totalCrossrefCites:0,authors:[null]},{id:"82341",title:"Circular Economy - Recent Advances in Sustainable Construction Waste Management",slug:"circular-economy-recent-advances-in-sustainable-construction-waste-management",totalDownloads:15,totalCrossrefCites:0,authors:[null]},{id:"82278",title:"Use of Saline Waste from a Desalination Plant under the Principles of the Circular Economy for the Sustainable Development of Rural Communities",slug:"use-of-saline-waste-from-a-desalination-plant-under-the-principles-of-the-circular-economy-for-the-s",totalDownloads:15,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"429339",firstName:"Jelena",lastName:"Vrdoljak",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/429339/images/20012_n.jpg",email:"jelena.v@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"7326",title:"Phosphorus",subtitle:"Recovery and Recycling",isOpenForSubmission:!1,hash:"463481a56cd0f4b649285f54a9e5008c",slug:"phosphorus-recovery-and-recycling",bookSignature:"Tao Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/7326.jpg",editedByType:"Edited by",editors:[{id:"185487",title:"Associate Prof.",name:"Tao",surname:"Zhang",slug:"tao-zhang",fullName:"Tao Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10975",title:"Sewage",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"0933f9b6aa7b8c65e710e951e674997d",slug:"sewage-recent-advances-new-perspectives-and-applications",bookSignature:"Tao Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/10975.jpg",editedByType:"Edited by",editors:[{id:"185487",title:"Associate Prof.",name:"Tao",surname:"Zhang",slug:"tao-zhang",fullName:"Tao Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10215",title:"Circular Economy",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"161dc2ffcd5ef7e5f8144938ed7fe477",slug:"circular-economy-recent-advances-new-perspectives-and-applications",bookSignature:"Tao Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/10215.jpg",editedByType:"Edited by",editors:[{id:"185487",title:"Associate Prof.",name:"Tao",surname:"Zhang",slug:"tao-zhang",fullName:"Tao Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"71158",title:"A Shamanskii-Like Accelerated Scheme for Nonlinear Systems of Equations",doi:"10.5772/intechopen.87246",slug:"a-shamanskii-like-accelerated-scheme-for-nonlinear-systems-of-equations",body:'\nA large aspect of scientific and management problems is often formulated by obtaining the values of
where
where
In general, the problem to be considered is that for some function
This often used to represent an instantaneous change of the function at some given points [5].
\nThe Taylor’s series expansion of the function
However, continuous differentiable vector valued function does not satisfy the mean value theorem (MVT), an essential tool in calculus [6]. Hence, academics suggested the use of the following theorem to replace the mean valued theorem.
\nMost of the algorithms employ for obtaining the solution of Eq. (1) centered on approximating the Jacobian matrix which often provides a linear map
Also, if
where
If all the given component functions
The most famous method for solving nonlinear systems of equations
where
The rate of convergence is linear and improves as the initial point gets better. Suppose
The convergence theorems and proof of Eq. (7) can be referred to [9, 10]. Motivated by the excellent convergence of Newton method and low cost of Jacobian evaluation of chord method, a method due originally to Shamanskii [11, 12] that lies between Newton method and chord method was proposed and has been analyzed in Kelly [9, 13, 14, 15]. Other variants of Newton methods with different Jacobian approximation schemes include [9, 14, 16, 17, 18]. However, most of these methods require the computation and storage of the full or approximate Jacobian, which become very difficult and time-consuming as the dimension of systems increases [10, 19].
\nIt would be worthwhile to construct a derivative-free approach and analyze with existing techniques [20, 21, 22]. The aim of this work is to derive a diagonal matrix for the approximate Jacobian of Shamanskii method by means of variational techniques. The expectation would be to reduce computational cost, storage, and CPU time of evaluating any problem. The proposed method works efficiently by combining the good convergence rate of Shamanskii method and the derivate free approach employed, and the results are very encouraging. The next section presents the Shamanskii method for nonlinear systems of equations.
\nIt is known that the Newton method defined in Eq. (2) converges quadratically to
Motivated by this, a method due originally to Shamanskii [11] was developed and analyzed by [7, 13, 14, 16, 24]. Starting with an initial approximation
after little simplification, we have
\nThis method converges superlinearly with
Combining Eq. (7) and the quadratic convergence of Newton method produces the convergence rate of the Shamanskii method as in Eq. (8). Thus, the balance is between the reduced evaluation cost of Fréchet derivative and Jacobian computation for Shamanskii method and Newton method rapid convergence. This low-cost derivative evaluation as well as the rapid convergence rate of several methods including the Shamanskii method has been studied and analyzed in [13, 15]. From the analysis, the researchers conclude that that Shamanskii method has shown superior performance compared to Newton method in terms of efficiency whenever work is measured in terms of function evaluations [9]. Also, if the value of
Evaluation or inversion of the Jacobian matrix at every iteration or after few iterations does not seem relevant even though the computational cost has generally been reduced as in Shamanskii method [14, 25, 26, 27, 28]. As a matter of fact, it can be easily shown that by adding a diagonal updating scheme to a method, we would have a new low memory iterative approach which would approximate the Jacobian
Given an initial approximation
Suppose
Substituting Eq. (12) in Eq. (13), we have
\nSince
which would be used to minimize the deviation between
such that Eq. (15) holds and
where
where
and
\nAlso, for diagonal matrix
This completes the proof.
Now, from the above description of the theorem, we deduce that the best possible diagonal update
However, for possibly small
Thus, the proposed accelerated method is described as follows:
\nThe performance of this proposed method would be tested on well-known benchmark problems employed by researchers on existing methods. This would be carried out using a designed computer code for its algorithm. The problems could be artificial or real-life problems. The artificial problems check the performance of any algorithm in situation such as point of singularity, function with many solutions, and null space effect as presented in Figures 1
Functions with a huge number of significant local optima.
Functions with significant null space.
Essentially unimodal function.
While the real-life problems emerge from fields such as chemistry, engineering, management, etc., the real-life problems often contain large data or complex algebraic expression which makes it difficult to solve.
\nThis section demonstrates the proposed method and illustrates its advantages on some benchmark problems with dimensions ranging from 25 to 1,000 variables. These include problems with restrictions such as singular Jacobian or problems with only one point of singularity. To evaluate the performance of the proposed diagonal updating Shamanskii method (DUSM), we employ some tools by Dolan and Moré [33] and compare the performance with two classical Newton-type methods based on the number of iterations and CPU time in seconds. The methods include:
The Newton method (NM)
The Shamanskii method (SM)
These tools are used to represent the efficiency, robustness, and numerical comparisons of different algorithms. Suppose there exist
Requiring a baseline for comparisons, they compared the performance on problem
We suppose that parameter
Thus,
All problems considered in this research are solved using MATLAB (R 2015a) subroutine programming [37]. This was run on an Intel® Core™ i5-2410M CPU @ 2.30 GHz processor, 4GB for RAM memory and Windows 7 Professional operating system. The termination condition is set as
\nand the program has been designed to terminate whenever:
The number of iterations exceeds 500, and no point of
The CPU time in seconds reaches 500.
Insufficient memory to initiate the run.
At the point of failure due to any of the above conditions as in the tabulated results, it is assumed the number of iteration and CPU time is zero and thus that point has been denoted by “
Table 1 shows the number of iterations (NI) and CPU time for Newton method (NM), Shamanskii method (SM), and the proposed diagonal updating method (DUSM), respectively. The performance of these methods was analyzed via storage locations and execution time. It can be observed that the proposed DUSM was able to solve the test problems perfectly, while NM and SM fail at some points due to the matrix being singular to working precision. This shows that the diagonal scheme employed has provided an option in the case of singularity, thereby reducing the computational cost of the classical Newton-type methods.
\nProblem | Dim | NM | DUSM | SM | |||
---|---|---|---|---|---|---|---|
NI | CPU | NI | CPU | NI | CPU | ||
1 | 25 | 13 | 0.016102 | 8 | 0.034777 | 13 | 0.015999 |
2 | 25 | 6 | 0.009522 | 7 | 0.028231 | 7 | 0.010412 |
3 | 25 | * | * | 4 | 0.023766 | * | * |
4 | 25 | 16 | 0.019679 | 17 | 0.077072 | 22 | 0.022889 |
5 | 25 | 4 | 0.006605 | 16 | 0.061750 | 4 | 0.005761 |
1 | 50 | 13 | 0.032998 | 8 | 0.090310 | 13 | 0.032271 |
2 | 50 | 10 | 0.022134 | 7 | 0.089785 | 7 | 0.017036 |
3 | 50 | 4 | 0.010350 | 4 | 0.052899 | 4 | 0.010238 |
4 | 50 | 30 | 0.054640 | 17 | 0.228077 | 23 | 0.041569 |
5 | 50 | 4 | 0.012361 | 16 | 0.201262 | 4 | 0.010735 |
1 | 100 | 13 | 0.073565 | 8 | 0.339333 | 13 | 0.066363 |
2 | 100 | 10 | 0.054075 | 7 | 0.292001 | 7 | 0.044512 |
3 | 100 | * | * | 4 | 0.175300 | * | * |
4 | 100 | 15 | 0.075073 | 18 | 0.770165 | 25 | 0.118170 |
5 | 100 | 4 | 0.029221 | 17 | 0.755556 | 4 | 0.023154 |
1 | 1000 | 13 | 1.868606 | 8 | 27.171776 | 13 | 2.042222 |
2 | 1000 | 10 | 1.444533 | 7 | 24.295632 | 7 | 1.045329 |
3 | 1000 | * | * | 4 | 27.1250 | * | * |
4 | 1000 | 52 | 6.757533 | 19 | 63.981376 | 39 | 5.138997 |
5 | 1000 | 4 | 0.610145 | 18 | 62.364143 | 4 | 0.612590 |
Numerical comparison of NM, DUSM, and SM.
This chapter proposes a diagonal updating formula for systems of nonlinear equations which attributes to reduction in Jacobian evaluation cost. By computational experiments, we reach the conclusion that the proposed scheme is reliable and efficient and reduces Jacobian computational cost during the iteration process. Meanwhile, the proposed scheme is superior compared to the result of the classical and existing numerical methods for solving systems of equations.
\nIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible, fibrotic lung disease with unidentifiable etiology. IPF is commonly seen in the elderly aged group [1]. IPF associates with high morbidity and mortality. It is crucial to diagnose IPF, as specific antifibrotic therapy may improve survival from 2 to 5 years to 6.9–7.9 years [2].
In 2000, the American Thoracic Society (ATS), the European Respiratory Society (ERS), and American College of Chest Physician (ACCP) first collaborated and published a consensus statement for IPF diagnosis and treatment based on an experts’ opinions. This initial definition of IPF included criteria such as usual interstitial pneumonia (UIP) finding on thoracic or open lung biopsy, restrictive lung function in patients with chronic fibrosing interstitial pneumonia after excluding other causes [3].
Eleven years later, ATS, ERS, the Japanese Respiratory Society (JRS), and the Latin American Thoracic Association (ALAT) updated the guidelines with clinical, imaging, and histopathological findings in IPF diagnostic criteria based on the international evidence-based data [4]. Among patients for whom IPF was suspected, three high-resolution computed tomography (HRCT) pattens were reported; “UIP,” “possible UIP,” and “inconsistent with UIP” [4]. Surgical lung biopsy (SLB) was recommended in patients with suspected IPF who have the last two HRCT patterns [4]. SLB pattern is primarily divided into “UIP,” “probable UIP”, “possible UIP”, “unclassifiable fibrosis,” and “not UIP” [4]. Recommendations from French, German and Swiss have been proposed in 2013 and 2017, respectively [5].
In 2018, the consensus statement from Fleischner Society and clinical practice guideline ATS/ERS/JRS/ALAT for UIP/IPF diagnosis were published with numbers of similar main components (Table 1) [6, 7]. With more support data from observational studies and randomized controlled trials than 2011 guidelines, diagnosis and treatment recommendations were improved from 2011. Recently, the German respiratory society updated the German guidelines for the diagnosis of IPF in 2021 [8].
Fleischner Society consensus statement | ATS/ERS/JRS/ALAT 2018 CPG | ||
---|---|---|---|
HRCT findings | |||
Location | Subpleural & basal predominance | ||
Pattern | Honeycombing ± traction bronchiectasis | ||
Biopsy | Not recommended | ||
Location | Subplerual & basal prodominance | ||
Pattern | Traction bronchiectasis | ||
Biopsy | Not recommended | Recommended (conditional) | |
Location | Diffuse or variable | Subpleural & Basal predominant | |
Pattern | Non-UIP features | Distortion, groud glass opacity | |
Biopsy | Recommended | ||
Pattern | Feature of other diseases | ||
Biopsy | Recommended | ||
Location | Subplerual & paraseptal prodominance | ||
Pattern | Architecture remodeling, dense/patchy fibrosis, fibroblast foci | ||
Pattern | Honeycombing ± fibroblastic foci | ||
Pattern | Centrilobular injury/scarring foci Mild lymphoid hyperplasia/diffuse inflammation Diffuse homogenous fibosis | Fibrosis ± architectural distortion Some UIP | |
Pattern | UIP + finding highly suggestive of another diagnosis or non-UIP | Feature of other diseases |
Comparison of the 2018 Fleischner society consensus statement and clinical practice guideline from ATS/ERS/JRS/ALAT 2018 for UIP/IPF diagnosis [6, 7].
ATS: American Thoracic Society; CPG: clinical practice gruidline, ERS: European Respiratory Society; IPF: idiopathic pulmonary fibrosis, JRS: Japanese Respiratory Society; ALAT: Latin American Thoracic Society; HRCT: high-resolution computed tomography; UIP: usual interstitial pneumonia.
Not only HRCT and SLB, but clinical manifestations, history, and other diagnostic modalities have also been proposed to help with IPF diagnosis. Multidisciplinary discussion is of utmost importance. Due to the rapidly growing of new data in the IPF field, guidelines from worldwide pulmonary societies consensus are necessary. We will discuss the current evidence that has been used to improve the diagnosis of IPF.
IPF is typically present at age above 50 years and is predominant in men [1, 9]. Lungs are the only organ involvement in IPF. Gradual onset of shortness of breath on exertion is the most common symptom that accounts for up to 86% of the patients with IPF, which can progress to shortness of breath at rest. Chronic nonproductive cough can be found in up to 75% of the cases [10]. Other symptoms include fatigue and decreased appetite. As IPF requires the diagnosis of exclusion, autoimmune diseases, connective tissue disease-related symptoms (e.g., arthralgia, dry eyes, Raynaud phenomenon), medications, radiation history, environment exposure (e.g., home, workplace, frequent visit places, hobbies), occupation, family history should be inquired in detailed to rule out any identifiable conditions. The physical exam is usually remarkable for bibasilar crackles and rales [6]. Digital clubbing was described in 20–30% of IPF cases [8].
Smoking is an undeniable risk factor of IPF in several studies [11]. Up to 70% of patients with IPF have a smoking history. Ever tobacco smoking or even secondhand smoking cases had a higher risk of developing IPF, although the latter had lower odds [9]. The pathogenesis of smoking as the risk factor of IPF is suggested to be due to oxidative stress [12].
Chronic obstructive pulmonary disease, co-morbidity that smoking is a potent risk factor, was found in one-third of the IPF cases. Gastroesophageal reflux disease (GERD) was noted in 60–90% of the patients with IPF and was thought to cause micro-aspiration that may precipitate IPF and acute exacerbation. The majority of GERD in IPF patients are asymptomatic. Nonetheless, the relationship between GERD and IPF remains controversial as there was no significant relationship after controlling for smoking in meta-regression [13]. Diabetes was positively correlated with IPF, but causal relationships still cannot determinate [14]. The presence of obstructive sleep apnea in patients with IPF was noted to be more than 50%, but true prevalence still cannot be concluded due to the small number of participants in those studies [15]. Chronic human herpes virus-7, human herpes virus-8, Ebstein-Barr virus, and cytomegalovirus infection could increase the risk of IPF [2]. However, acute infection of these viruses did not associate with IPF [2].
The environmental exposure was reported in up to 27% [10]. Various occupational exposure has been revealed to be associated with IPF (Table 2). Silica, wood dust, metal dust/fumes, and vapors/gases/dust/fume had population attributable fractions of 3,4, 8, and 26%, respectively [16]. Deposition of dust and fumes from metal in the lung may give rise to the disturbance in the immune system. IPF risk has been reported to be increased with the longer duration of work exposure. In a meta-analysis of case–control studies by Park et al., metal dust, wood dust, pesticide had a high odds ratio (OR) in the IPF group [11]. However, textile dust, stone, and sand dust did not significantly increase the risk of IPF in this meta-analysis study [11]. The agriculture sector and farming workers showed an increased risk of IPF with an OR of 1.88 (95% CI 1.17–3.04). In contrast, demolition and building construction, and woodworker carpentry did not significantly increase the risk of IPF [11].
Tobacco Smoking |
Chronic viral infection (human herpes virus-7, human herpes virus-8, Ebstein-Barr virus, cytomegalovirus) |
Exposure (e.g., metal dust, wood dust, pesticide) |
Agriculture and farming worker |
Family history of pulmonary fibrosis |
Potential risk factors for IPF.
Although IPF cases occur sporadically, familial cases have been reported, such as familial pulmonary fibrosis (FPF), Hermansky-Pudlak syndrome (HPS), and telomere-related mutation (Table 3). Genetic testing is recommended in patients with early-onset (less than 50 years old) pulmonary fibrosis and positive family history.
Familial pulmonary fibrosis |
Hermansky-Pudlak syndrome |
Telomere-related mutation |
Family history related to IPF.
FPF is defined by two or more people in the family with a confirmed history of pulmonary fibrosis [17]. It accounts for less than five to up to 25 percent of IPF cases [18]. Pulmonary fibrosis in the family had a significant association with IPF cases with an OR of 12.6 (95% confidence interval 6.5–24.2) [9]. In addition to aiding diagnosis, family history helps predict survival. Transplant-free survival in patient-reported FPF is less in patients with IPF than patients with interstitial lung disease (ILD) other than IPF [18].
HPS, an autosomal recessive disorder, was first described in 1959 by Frantisek Hermansky and Paulus Pudlak [19]. This syndrome is characterized by oculocutaneous albinism, inflammatory bowel disease, platelet dysfunction, and pulmonary fibrosis. Pulmonary fibrosis is commonly found in HPS-1, HPS-2, and HPS-4 genetic types and affected middle-aged (HPS-1 and HPS-4) or children (HPS-2) [19].
Telomere-related mutation in IPF includes TERT, TERC, TINF2, NAF1, PARN, DKC1, and RTEL1 [20]. Premature shortening of the telomere, a region at the ends of the chromosome with repetitive DNA sections, may lead to the accelerated aging process in IPF. Screening for short telomeres should be done in patients with extrapulmonary organ involvements associated with short telomere syndrome, especially patients considered for a lung transplant. Patients with shortened telomeres have decreased lung transplant-free survival and faster disease progression [20].
High-resolution CT scan (HRCT) plays a central role in the diagnosis of IPF. As described earlier, diagnosis of IPF requires exclusion of other known causes of ILD in addition to the presence of UIP pattern on HRCT. If HRCT shows a definitive UIP pattern, further surgical lung biopsy is not required for diagnosis. HRCT patterns in suspected IPF patients can be divided into four patterns: UIP, intermediate UIP, probable UIP, and alternative diagnosis (Table 4). All the patterns are characterized by their distribution and lung parenchymal appearance [6].
UIP | Probable UIP | Indeterminate UIP | Alternative diagnosis |
---|---|---|---|
|
|
|
|
HRCT pattern categories.
UIP = usual interstitial pneumonia; GGO = ground glass opacities; CT = computed tomography; CTD = connective tissue disease; RA = rheumatoid arthritis.
UIP is the hallmark pattern of IPF. It has characteristic bilateral, peripheral, lower lobe predominance with parenchymal findings of honeycombing and traction bronchiectasis along with fine reticular opacities in the absence of extensive ground-glass opacities. Honeycombing is defined as a group of cystic airspaces 3 to 10 mm in diameter, with well-defined, thick walls. It is absent in intermediate and probable UIP patterns. Traction bronchiectasis or bronchiolectasis ranges from non-tapering of the bronchial wall to marked airway dilatation and varicosity in the presence of parenchymal distortion [6]. A typical UIP pattern is only observed in 50% of IPF patients. Thus, the IPF spectrum varies from typical UIP patterns to atypical findings such as ground-glass opacities, nodules, consolidation, or atypical distribution [21]. Mild ground glass opacities and the reticular pattern can be seen in UIP. However, presence of GGO out of proportion to the reticular pattern is inconsistent with UIP.
Acute exacerbation of IPF is characterized by acute onset dyspnea and hypoxemia and development of bilateral ground-glass opacities and/or consolidation on a UIP background. The clinical course of IPF can be correlated with progressive lung parenchymal changes seen on serial HRCT scans. However, there is no consensus on the role of serial HRCT scans in established patients to determine prognosis [22].
Serological testing is recommended in all patients with newly identified ILD to exclude identifiable connective tissue disease (CTD) [6]. CTD-associated ILD investigations include erythrocytes sedimentation rate, C-reactive protein, anti-nuclear antibodies, rheumatoid factors, anti-cyclic citrullinated peptide, myositis panel, muscle enzymes, and anti-neutrophil cytoplasmic antibodies. Other serologic testing may be obtained based on clinical signs and symptoms such as anti-U1 ribonucleoprotein, anti-PM/Scl75 (polymyositis/scleroderma 75), anti-PM/Scl100, anti-Ku, anti-nuclear matrix protein 2, anti-transcriptional intermediary factor 1-gamma, anti-signal recognition particle, anti-small ubiquitin-related modifier-activating enzyme, anti-3-hydroxy-3-methylglutaryl-CoA reductase, and anti-melanoma differentiation-associated protein 5 (Table 5) [8].
Systemic sclerosis | anti–Scl70/topoisomerase-1, anti-centromere, anti-RNA polymerase III, anti-Th/To, U3 RNP (fibrillarin), and anti-Ku |
---|---|
anti-Ro and anti-La | |
Creatine phosphokinase, myoglobin, aldolase, antisynthetase antibodies (anti-Jo-1 and others), anti-MDA5, anti-PM/Scl75, anti-PM/Scl100, anti-TIF1- γ, anti-SEP, anti-HMGCR, anti NXP2, anti-U1RNP | |
Rheumatoid factor, anti-cyclic citrullinated peptide | |
Antineutrophil cytoplasmic antibodies, anti myeloperoxidase antibodies, antiproteinase 3 antibodies |
Laboratory workup for common connective tissue disease-related interstitial lung diseases.
Cellular analysis from bronchoalveolar lavage (BAL) fluid is suggested in suspected IPF cases with probable UIP, indeterminate UIP, or an alternative diagnosis pattern on HRCT. This work-up is not suggested for patients with HRCT patterns of UIP [6]. BAL is not used for the IPF diagnosis by itself but might support the detection of other conditions (Tables 6 and 7).
BAL | Macrophages | Lymphocytes | Neutrophils | Eosinophils | CD4/CD8 |
---|---|---|---|---|---|
Healthy individual | >85% | 10–15% | <3% | ≤1% | 49–83% |
IPF | 49–83% | 7–27% | 6–22% | 2–8% | 1–3% |
Comparison of cellular analysis from bronchoalveolar lavage between a healthy individual and IPF [6].
Lymphocytic predominance | Sarcoidosis, HP, NSIP, Drug-induced, Radiation, COP, Lymphoproliferative disorders, CTD |
---|---|
CTD, IPF, aspiration, infection, bronchitis, asbestosis, ARDS/DAD | |
Eosinophilic pneumonia, Drug-induced, BM transplant, asthma, ABPA, Hodgkin, infection |
Cellular analysis of bronchoalveolar lavage in different conditions.
Multiple lung biopsies from few lobes are suggested in suspected IPF cases with probable UIP, indeterminate UIP, or alternative diagnosis patterns on HRCT. SLB is preferred over transbronchial lung biopsy and cryobiopsy. SLB be done by video-assisted thoracoscopic surgical (VATS) technique over open thoracotomy. When patients have a UIP pattern on HRCT, lung biopsy is not recommended in clinically suspected IPF patients after excluded other potential ILD etiologies. In these cases, diagnosis of IPF can be made without histopathology proof.
Similar to the HRCT pattern, histopathology patterns in suspected IPF individuals can be categorized into four groups; UIP, probable UIP, indeterminate UIP, and alternative diagnosis (Table 8) [6]. Classic “UIP” is the principal histopathologic feature of IPF. It frequently demonstrates dense fibrosis in paraseptal and subpleural areas of the lung with distortion of architecture, often resulting in microscopic honeycombing pattern accompanied by unaffected lung parenchyma in the low-magnification photomicrograph. For higher-magnification photomicrographs, fibroblast foci and patchy fibrosis are characteristics of UIP. The honeycombing pattern on biopsy is defined as fibrosed cystic airspace.
UIP | Probable UIP | Indeterminate UIP | Alternative diagnosis |
---|---|---|---|
|
No features of an alternative diagnosis |
Non-UIP pattern or Interstitial inflammation, chronic fibrous pleuritis, OP, granuloma, hyaline membraines, airway-centered
|
|
Histopathologic feature of idiopathic pulmonary fibrosis [6].
HP = hypersensitivity pneumonitis; IIPs = Idiopathic interstitial pneumonias; LAM = Lymphangioleiomyomatosis; OP = organizing pneumonia; UIP = usual interstitial pneumonia.
Accurate diagnosis of IPF requires the synopsis consideration of clinical manifestation, HRCT, and biopsy results (Table 9). When the HRCT pattern of clinically suspected IPF patients is not classic UIP or discordant with biopsy result, the multidiscipline decision from different subspecialties discussion such as pulmonologist, radiologist, and pathologist is suggested [6].
Biopsy result | |||||
---|---|---|---|---|---|
Clinically suspected IPF after exclusion of other ILD causes | UIP | Probable UIP | Indeterminate for UIP | Alternative diagnosis | |
IPF A biopsy is not recommended | |||||
IPF | IPF | Likely IPF | Not IPF | ||
IPF | Likely IPF | Not IPF | Not IPF | ||
Likely IPF | Not IPF | Not IPF | Not IPF |
Diagnosis of IPF using surgical lung biopsy result and high-resolution computed tomography finding [6].
HRCT = high-resolution computed tomography; IPF=Idiopathic pulmonary fibrosis; UIP = usual interstitial pneumonia.
Genetic factors affecting the susceptibility to IPF mainly depend on whether a patient has sporadic IPF or familial IPF. With the increase in the use of genome sequencing, multiple gene variants have been associated with IPF. Common variants with modest effects have been associated with sporadic IPF, whereas rare gene variants with more significant impact have been associated with a familial form of IPF.
Mucin 5B (MUC5B) variant is a common variant associated with sporadic IPF. It is a glycoprotein involved in mucociliary clearance. A MUC5B promoter single nucleotide polymorphism (rs35705950) increases the susceptibility to developing IPF four-fold [23]. Despite this, MUC5B promoter SNP is associated with decreased mortality in IPF patients. However, it is not associated with systemic scleroderma-related ILD can increase the risk of ILD in rheumatoid arthritis patients, especially in those having CT findings of UIP.
Toll interacting protein (TOLLIP) is a regulator of toll-like receptor (TLR), and variation in this gene leads to a decrease in TLR mRNA expression and increased risk of pulmonary infection [24]. TT TOLLIP genotype ((rs3750920) is associated with improved survival with N-acetyl cysteine treatment [25]. However, the other minor allele of TOLLIP (rs5743890) decreases the susceptibility to IPF development but is associated with increased mortality from IPF [26].
Desmoplakin (DSP) encodes for desmoplakin, an adhesion molecule between 2 cells and tethers the cytoskeleton to the cell membrane. Two variants in DSP have been identified in which one variant (rs2744371) is protective, whereas the other variant (rs2076295) increases the susceptibility to IPF [27].
A-kinase Anchoring protein 13 (AKAP13) is a regulator of rhoA, which is involved in the profibrotic signaling pathway. Single nucleotide polymorphism in AKAP13 has also been associated with an increased risk of IPF. AKAP 13 mRNA expression was higher in the lung biopsy section of IPF patients compared to controls [28].
Various surfactant-producing gene mutations have been identified, such as SFPT-C and SFPT-A2 associated with IPF in families. Transcription and translation of the SFPT-C gene leads to pro-SPC formation, which is further processed in the endoplasmic reticulum before being secreted in the alveolar space. SFPT-C mutation leads to the formation of pro-SPC. However, it cannot be further processed and folded, leading to protein accumulation within the endoplasmic reticulum and thus, activating unfolded protein response (UPR) within the cell. Unfolded protein response helps to protect the cell and also enhances protein folding chaperones. However, prolonged standing activation of UPR system leads to alveolar epithelial cell death through apoptosis [29]. Studies have shown markers for endothelium reticulum stress and UPR pathway activation even in the absence of SFPT-C mutation. These studies demonstrate that this pathway may contribute to the pathogenesis of IPF [30]. Similarly, SFTP-A2 gene mutations have been identified in a family with 15 members who had familial IPF, bronchoalveolar carcinoma, or underlying lung disease. SFTP-A2 also accumulates mutant surfactant protein A within the endoplasmic reticulum, leading to stress and ultimate activation of the apoptotic pathway [31].
Telomerase complex mutations have been identified in families with UIP. Telomeres are the tandem repeats of TTAGGG found at both ends of chromosomes, protecting the end of chromosomes during cell division. Telomerase helps maintain these telomeres length. Telomerase mutation leads to the shortening of telomere in the alveolar epithelial cells, which was found to be involved in the disease process. Telomere shortening has also been observed in peripheral leukocytes in these patients. New studies have shown shortened telomere length in patients with sporadic IPF and non-telomerase complex mutation IPF, indicating it might play a role in the pathogenesis of IPF [32].
Other molecular biomarkers such as elevated levels of matrix metalloproteinase 7 (MMP 7), mucin 1 (KL-6), CC chemokine ligand 18 (CCL 18), cancer antigen have also been associated with disease progression but have limited clinical value at present and requires further studies [33].
Thus, the use of genetic and biologic biomarkers can further help understand the pathogenesis of IPF and develop future targeted therapies. However, currently, more studies are required to use these markers for diagnostic purposes.
When encountering patients with clinical context and tempo of disease compatible with IPF, excluding identifiable causes by acquiring history and serology is recommended. Other investigations such as biomarkers may aid the defining of IPF. After that, IPF diagnosis can be made with the UIP pattern shown by HRCT. In patients with HRCT patterns of non-UIP, a surgical lung biopsy will assist the diagnosis. When a definite diagnosis cannot be concluded by UIP pattern from HRCT or biopsy result, the mutual agreement from the multidisciplinary discussion is recommended to help diagnose IPF.
IntechOpen has always supported new and evolving ideas in scholarly publishing. We understand the community we serve, but to provide an even better service for our IntechOpen Authors and Academic Editors, we have partnered with leading companies and associations in the scientific field and beyond.
",metaTitle:"Partnerships",metaDescription:"IntechOpen was built by scientists, for scientists. We understand the community we serve, but to bring an even better service to the table for IntechOpen Authors and Academic Editors, we partnered with the leading companies and associations in the industry and beyond.",metaKeywords:null,canonicalURL:"/page/partnerships",contentRaw:'[{"type":"htmlEditorComponent","content":"\\n"}]'},components:[{type:"htmlEditorComponent",content:'
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{mdrv:"www.intechopen.com"},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:8616},{group:"region",caption:"Middle and South America",value:2,count:7693},{group:"region",caption:"Africa",value:3,count:3005},{group:"region",caption:"Asia",value:4,count:15646},{group:"region",caption:"Australia and Oceania",value:5,count:1284},{group:"region",caption:"Europe",value:6,count:22554}],offset:12,limit:12,total:134465},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"8,9,10,11,14,15,20,22,24"},books:[{type:"book",id:"11124",title:"Next-Generation Textiles",subtitle:null,isOpenForSubmission:!0,hash:"093f9e26bb829b8d414d13626aea1086",slug:null,bookSignature:"Dr. Hassan Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/11124.jpg",editedByType:null,editors:[{id:"90645",title:"Dr.",name:"Hassan",surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11561",title:"Zeolite From Wastes - New Perspectives on Innovative Resources and Their Valorization Process",subtitle:null,isOpenForSubmission:!0,hash:"3ed0dfd842de9cd1143212415903e6ad",slug:null,bookSignature:"Dr. Claudia Belviso",coverURL:"https://cdn.intechopen.com/books/images_new/11561.jpg",editedByType:null,editors:[{id:"61457",title:"Dr.",name:"Claudia",surname:"Belviso",slug:"claudia-belviso",fullName:"Claudia Belviso"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11662",title:"Limnology - The Importance of Monitoring and Correlations of Lentic and Lotic Waters",subtitle:null,isOpenForSubmission:!0,hash:"f1043cf6b1daae7a7b527e1d162ca4a8",slug:null,bookSignature:"Dr. Carmine Massarelli and Dr. Claudia Campanale",coverURL:"https://cdn.intechopen.com/books/images_new/11662.jpg",editedByType:null,editors:[{id:"315689",title:"Dr.",name:"Carmine",surname:"Massarelli",slug:"carmine-massarelli",fullName:"Carmine Massarelli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11529",title:"Product Design - A Manufacturing Perspective",subtitle:null,isOpenForSubmission:!0,hash:"b6f9e61bc85962bbae25e2aa2e1bb22e",slug:null,bookSignature:"Ph.D. Evren Yasa and Dr. Ozgur Poyraz",coverURL:"https://cdn.intechopen.com/books/images_new/11529.jpg",editedByType:null,editors:[{id:"219594",title:"Ph.D.",name:"Evren",surname:"Yasa",slug:"evren-yasa",fullName:"Evren Yasa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11759",title:"Copper - From the Mineral to the Final Application",subtitle:null,isOpenForSubmission:!0,hash:"afea7aef1cb09fc3a1a5d619152d02a6",slug:null,bookSignature:"Dr. Daniel Fernández González and Dr. Luis Felipe Verdeja González",coverURL:"https://cdn.intechopen.com/books/images_new/11759.jpg",editedByType:null,editors:[{id:"211395",title:"Dr.",name:"Daniel",surname:"Fernández González",slug:"daniel-fernandez-gonzalez",fullName:"Daniel Fernández González"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11860",title:"Holography - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"dc0d34170f033ec1ab982bd15773bb2d",slug:null,bookSignature:"Prof. Joseph Rosen",coverURL:"https://cdn.intechopen.com/books/images_new/11860.jpg",editedByType:null,editors:[{id:"16544",title:"Prof.",name:"Joseph",surname:"Rosen",slug:"joseph-rosen",fullName:"Joseph Rosen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11545",title:"Tunnel Engineering - Modelling, Construction and Monitoring Techniques",subtitle:null,isOpenForSubmission:!0,hash:"abfea4d94310e94cba417826644c59d5",slug:null,bookSignature:"Dr. Kenneth Imo-Imo Israel Eshiet",coverURL:"https://cdn.intechopen.com/books/images_new/11545.jpg",editedByType:null,editors:[{id:"195037",title:"Dr.",name:"Kenneth Imo-Imo Israel",surname:"Eshiet",slug:"kenneth-imo-imo-israel-eshiet",fullName:"Kenneth Imo-Imo Israel Eshiet"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11501",title:"Qualitative and Computational Aspects of Dynamical Systems",subtitle:null,isOpenForSubmission:!0,hash:"d9d21a5db7515233f254abc02d89c2be",slug:null,bookSignature:"Dr. Kamal Shah, Dr. . Eiman and Dr. Arshad Ali",coverURL:"https://cdn.intechopen.com/books/images_new/11501.jpg",editedByType:null,editors:[{id:"231748",title:"Dr.",name:"Kamal",surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11840",title:"Arid Environment - Perspectives, Challenges and Management",subtitle:null,isOpenForSubmission:!0,hash:"4c2e03f295fbc697350f0bf3bf89a14f",slug:null,bookSignature:"Associate Prof. Murat Eyvaz, Dr. Ahmed Albahnasawi, M.Sc. Ercan Gürbulak and MSc. Mesut Tekbaş",coverURL:"https://cdn.intechopen.com/books/images_new/11840.jpg",editedByType:null,editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11862",title:"The Essence of Large-Eddy Simulations",subtitle:null,isOpenForSubmission:!0,hash:"45f71667f509dc3d62f6650fd3a1060e",slug:null,bookSignature:"Dr. Aamir Shahzad",coverURL:"https://cdn.intechopen.com/books/images_new/11862.jpg",editedByType:null,editors:[{id:"288354",title:"Dr.",name:"Aamir",surname:"Shahzad",slug:"aamir-shahzad",fullName:"Aamir Shahzad"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11446",title:"Industry 4.0 - Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"be984f45b90c1003798661ef885d8a34",slug:null,bookSignature:"Dr. Meisam Gordan and Dr. Khaled Ghaedi",coverURL:"https://cdn.intechopen.com/books/images_new/11446.jpg",editedByType:null,editors:[{id:"303193",title:"Dr.",name:"Meisam",surname:"Gordan",slug:"meisam-gordan",fullName:"Meisam Gordan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11485",title:"Wetting and Wettability - Fundamental and Applied Aspects",subtitle:null,isOpenForSubmission:!0,hash:"54b954378e0840f2317b2e94e6c467d6",slug:null,bookSignature:"Dr. Volodymyr Shatokha",coverURL:"https://cdn.intechopen.com/books/images_new/11485.jpg",editedByType:null,editors:[{id:"111000",title:"Dr.",name:"Volodymyr",surname:"Shatokha",slug:"volodymyr-shatokha",fullName:"Volodymyr Shatokha"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:36},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:22},{group:"topic",caption:"Computer and Information Science",value:9,count:23},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:14},{group:"topic",caption:"Engineering",value:11,count:60},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:14},{group:"topic",caption:"Materials Science",value:14,count:23},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:106},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:3}],offset:12,limit:12,total:164},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4438},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11042",title:"Complementary Therapies",subtitle:null,isOpenForSubmission:!1,hash:"9eb32ccbef95289a133a76e5808a525b",slug:"complementary-therapies",bookSignature:"Mario Bernardo-Filho, Redha Taiar, Danúbia da Cunha de Sá-Caputo and Adérito Seixas",coverURL:"https://cdn.intechopen.com/books/images_new/11042.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"157376",title:"Prof.",name:"Mario",middleName:null,surname:"Bernardo-Filho",slug:"mario-bernardo-filho",fullName:"Mario Bernardo-Filho"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10037",title:"Thermoelectricity",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"ad1d3f637564a29cf1636759f5401994",slug:"thermoelectricity-recent-advances-new-perspectives-and-applications",bookSignature:"Guangzhao Qin",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"188870",title:"Mr.",name:"Guangzhao",middleName:null,surname:"Qin",slug:"guangzhao-qin",fullName:"Guangzhao Qin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11357",title:"Sustainable Crop Production",subtitle:"Recent Advances",isOpenForSubmission:!1,hash:"ee41e09e4ad6a336ca9f0e5462da3904",slug:"sustainable-crop-production-recent-advances",bookSignature:"Vijay Singh Meena, Mahipal Choudhary, Ram Prakash Yadav and Sunita Kumari Meena",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"420235",title:"Dr.",name:"Vijay",middleName:null,surname:"Meena",slug:"vijay-meena",fullName:"Vijay Meena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10863",title:"Cardiac Rhythm Management",subtitle:"Pacing, Ablation, Devices",isOpenForSubmission:!1,hash:"a064ec49b85ebfc60585c9c3690af53a",slug:"cardiac-rhythm-management-pacing-ablation-devices",bookSignature:"Mart Min and Gabriel Cismaru",coverURL:"https://cdn.intechopen.com/books/images_new/10863.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"62780",title:"Prof.",name:"Mart",middleName:null,surname:"Min",slug:"mart-min",fullName:"Mart Min"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10874",title:"Insights on Antimicrobial Peptides",subtitle:null,isOpenForSubmission:!1,hash:"23ca26025e87356a7c2ffac365f73a22",slug:"insights-on-antimicrobial-peptides",bookSignature:"Shymaa Enany, Jorge Masso-Silva and Anna Savitskaya",coverURL:"https://cdn.intechopen.com/books/images_new/10874.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11137",title:"Mineralogy",subtitle:null,isOpenForSubmission:!1,hash:"e0e4727c9f1f9b34d788f0dc70278f2b",slug:"mineralogy",bookSignature:"Miloš René",coverURL:"https://cdn.intechopen.com/books/images_new/11137.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"142108",title:"Dr.",name:"Miloš",middleName:null,surname:"René",slug:"milos-rene",fullName:"Miloš René"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10882",title:"Smart Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"70c3ce4256324b3c58db970d446ddac4",slug:"smart-drug-delivery",bookSignature:"Usama Ahmad, Md. Faheem Haider and Juber Akhtar",coverURL:"https://cdn.intechopen.com/books/images_new/10882.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10885",title:"Snake Venom and Ecology",subtitle:null,isOpenForSubmission:!1,hash:"cc4503ed9e56a7bcd9f2ca82b0c880a8",slug:"snake-venom-and-ecology",bookSignature:"Mohammad Manjur Shah, Umar Sharif, Tijjani Rufai Buhari and Tijjani Sabiu Imam",coverURL:"https://cdn.intechopen.com/books/images_new/10885.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"94128",title:"Dr.",name:"Mohammad Manjur",middleName:null,surname:"Shah",slug:"mohammad-manjur-shah",fullName:"Mohammad Manjur Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10381",title:"Electrocatalysis and Electrocatalysts for a Cleaner Environment",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"9dbafb0b297cf5cbdb220707e022a228",slug:"electrocatalysis-and-electrocatalysts-for-a-cleaner-environment-fundamentals-and-applications",bookSignature:"Lindiwe Eudora Khotseng",coverURL:"https://cdn.intechopen.com/books/images_new/10381.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"236596",title:"Dr.",name:"Lindiwe Eudora",middleName:null,surname:"Khotseng",slug:"lindiwe-eudora-khotseng",fullName:"Lindiwe Eudora Khotseng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10900",title:"Prunus",subtitle:"Recent Advances",isOpenForSubmission:!1,hash:"9261926500acb26c4ae5a29eee78f0db",slug:"prunus-recent-advances",bookSignature:"Ayzin B. Küden and Ali Küden",coverURL:"https://cdn.intechopen.com/books/images_new/10900.jpg",editedByType:"Edited by",publishedDate:"July 6th 2022",editors:[{id:"200365",title:"Prof.",name:"Ayzin B.",middleName:"B.",surname:"Küden",slug:"ayzin-b.-kuden",fullName:"Ayzin B. Küden"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"53",title:"Genomics",slug:"genomics",parent:{id:"6",title:"Biochemistry, Genetics and Molecular Biology",slug:"biochemistry-genetics-and-molecular-biology"},numberOfBooks:16,numberOfSeries:0,numberOfAuthorsAndEditors:365,numberOfWosCitations:170,numberOfCrossrefCitations:150,numberOfDimensionsCitations:325,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"53",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10741",title:"Synthetic Genomics",subtitle:"From BioBricks to Synthetic Genomes",isOpenForSubmission:!1,hash:"eb1cebd0b9c4e7e87427003ff7196f57",slug:"synthetic-genomics-from-biobricks-to-synthetic-genomes",bookSignature:"Miguel Fernández-Niño and Luis H. Reyes",coverURL:"https://cdn.intechopen.com/books/images_new/10741.jpg",editedByType:"Edited by",editors:[{id:"158295",title:"Dr.",name:"Miguel",middleName:null,surname:"Fernández-Niño",slug:"miguel-fernandez-nino",fullName:"Miguel Fernández-Niño"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9744",title:"DNA",subtitle:"Damages and Repair Mechanisms",isOpenForSubmission:!1,hash:"470a5da792f88551c8380519604524a5",slug:"dna-damages-and-repair-mechanisms",bookSignature:"Payam Behzadi",coverURL:"https://cdn.intechopen.com/books/images_new/9744.jpg",editedByType:"Edited by",editors:[{id:"45803",title:"Ph.D.",name:"Payam",middleName:null,surname:"Behzadi",slug:"payam-behzadi",fullName:"Payam Behzadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9394",title:"Genotoxicity and Mutagenicity",subtitle:"Mechanisms and Test Methods",isOpenForSubmission:!1,hash:"9ee7e597358dbbfb5e33d0beb76e6fff",slug:"genotoxicity-and-mutagenicity-mechanisms-and-test-methods",bookSignature:"Sonia Soloneski and Marcelo L. Larramendy",coverURL:"https://cdn.intechopen.com/books/images_new/9394.jpg",editedByType:"Edited by",editors:[{id:"14863",title:"Dr.",name:"Sonia",middleName:null,surname:"Soloneski",slug:"sonia-soloneski",fullName:"Sonia Soloneski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8992",title:"Gene Expression and Phenotypic Traits",subtitle:null,isOpenForSubmission:!1,hash:"88ec966a7a8eecaf5cdbdc8b20295737",slug:"gene-expression-and-phenotypic-traits",bookSignature:"Yuan-Chuan Chen and Shiu-Jau Chen",coverURL:"https://cdn.intechopen.com/books/images_new/8992.jpg",editedByType:"Edited by",editors:[{id:"185559",title:"Dr.",name:"Yuan-Chuan",middleName:null,surname:"Chen",slug:"yuan-chuan-chen",fullName:"Yuan-Chuan Chen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9377",title:"Non-Coding RNAs",subtitle:null,isOpenForSubmission:!1,hash:"ff4f15e339216fa9426d2b9fdf3b5901",slug:"non-coding-rnas",bookSignature:"Lütfi Tutar, Sümer Aras and Esen Tutar",coverURL:"https://cdn.intechopen.com/books/images_new/9377.jpg",editedByType:"Edited by",editors:[{id:"158530",title:"Dr.",name:"Lütfi",middleName:null,surname:"Tutar",slug:"lutfi-tutar",fullName:"Lütfi Tutar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6582",title:"Chromatin and Epigenetics",subtitle:null,isOpenForSubmission:!1,hash:"afa23decc7c15bdf48cfeebb5f0c38fb",slug:"chromatin-and-epigenetics",bookSignature:"Colin Logie and Tobias Aurelius Knoch",coverURL:"https://cdn.intechopen.com/books/images_new/6582.jpg",editedByType:"Edited by",editors:[{id:"212809",title:"Associate Prof.",name:"Colin",middleName:null,surname:"Logie",slug:"colin-logie",fullName:"Colin Logie"}],equalEditorOne:{id:"68430",title:"Dr.",name:"Tobias Aurelius",middleName:null,surname:"Knoch",slug:"tobias-aurelius-knoch",fullName:"Tobias Aurelius Knoch",profilePictureURL:"https://mts.intechopen.com/storage/users/68430/images/system/68430.png",biography:"Born in the Rhein-Neckar region Mannheim/Heidelberg, Germany, Dr. Knoch studied Physics, Mathematics, and Biology at the University of Heidelberg. In 1998, he graduated in (bio-)physics with 'Three-Dimensional Organization of Chromosomes domains in Simulation and Experiment”, followed by his dissertation 'Approaching the Three-Dimensional Organization of the Human Genome' both at the German Cancer Research Center (DKFZ), Heidelberg, in 2002. In 2002/2004 Dr. Knoch founded his group Biophysical Genomics located at the Kirchhoff Institute for Physics, University of Heidelberg, and until today at the Cell Biology Department, Erasmus Medical Center, Rotterdam, The Netherlands. His work is focusing on the determination and understanding of genome organization from the DNA sequence level to the entire nuclear morphology. Therefore, approaches from theoretical physics have been combined with molecular biology in highly interdisciplinary projects ranging from advanced DNA sequence analyses, parallel high-performance computer modelling of genomic architectures, and new image analysis methods, to advanced fluorescence in situ hybridization and high-resolution chromatin conformation interaction genome mapping. Major achievements have been: an artefact-free in vivo labelling method of nuclear chromatin, the first system-biological genome browser (GLOBE 3D Genome Browser), the set-up of one of the largest desktop computing grids, and last but not least the final determination of the general structural organization of higher mammalian genomes leading to a consistent systems genomics view of genomes from genotype to phenotype. All this has resulted in patents, publications, the foundation/coordination of international interdisciplinary cooperative networks, and consortia. He also (co-)founded many initiatives improving institutional/university study and management performance including the science outreach to the public and industry. Besides, he also conducts environmental and human ecology research, has achieved law-changing contributions in the human-rights sector, is an increasingly recognized artist in the fine arts, and last but not least has founded and is running two companies in the renewable energy production and development sector. His achievements have resulted in prestigious scholarships, awards, and prices as early as 1983.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Erasmus University Medical Center",institutionURL:null,country:{name:"Netherlands"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6987",title:"Antisense Therapy",subtitle:null,isOpenForSubmission:!1,hash:"5d60550dc1e3afbb083fe61925b33caa",slug:"antisense-therapy",bookSignature:"Shashwat Sharad and Suman Kapur",coverURL:"https://cdn.intechopen.com/books/images_new/6987.jpg",editedByType:"Edited by",editors:[{id:"80113",title:"Dr.",name:"Shashwat",middleName:null,surname:"Sharad",slug:"shashwat-sharad",fullName:"Shashwat Sharad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8029",title:"Transcriptome Analysis",subtitle:null,isOpenForSubmission:!1,hash:"19e7bd55dd90a5187ee806a307ef112d",slug:"transcriptome-analysis",bookSignature:"Miroslav Blumenberg",coverURL:"https://cdn.intechopen.com/books/images_new/8029.jpg",editedByType:"Edited by",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7995",title:"Epigenetics",subtitle:null,isOpenForSubmission:!1,hash:"33c1f5868ce0c29fbde6eafdc50af702",slug:"epigenetics",bookSignature:"Rosaria Meccariello",coverURL:"https://cdn.intechopen.com/books/images_new/7995.jpg",editedByType:"Edited by",editors:[{id:"143980",title:"Prof.",name:"Rosaria",middleName:null,surname:"Meccariello",slug:"rosaria-meccariello",fullName:"Rosaria Meccariello"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8605",title:"DNA Repair",subtitle:"An Update",isOpenForSubmission:!1,hash:"f32305a1299fabc5119b721f69cc97cb",slug:"dna-repair-an-update",bookSignature:"Maddalena Mognato",coverURL:"https://cdn.intechopen.com/books/images_new/8605.jpg",editedByType:"Edited by",editors:[{id:"41691",title:"Dr.",name:"Maddalena",middleName:null,surname:"Mognato",slug:"maddalena-mognato",fullName:"Maddalena Mognato"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7331",title:"Modulating Gene Expression",subtitle:"Abridging the RNAi and CRISPR-Cas9 Technologies",isOpenForSubmission:!1,hash:"436fdc4857ca5c7f496e439de1034b6b",slug:"modulating-gene-expression-abridging-the-rnai-and-crispr-cas9-technologies",bookSignature:"Aditi Singh and Mohammad W. Khan",coverURL:"https://cdn.intechopen.com/books/images_new/7331.jpg",editedByType:"Edited by",editors:[{id:"240724",title:"Dr.",name:"Aditi",middleName:null,surname:"Singh",slug:"aditi-singh",fullName:"Aditi Singh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8891",title:"Gene Editing",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"25f0d7de56709fc0558c0bb8212a0d03",slug:"gene-editing-technologies-and-applications",bookSignature:"Yuan-Chuan Chen and Shiu-Jau Chen",coverURL:"https://cdn.intechopen.com/books/images_new/8891.jpg",editedByType:"Edited by",editors:[{id:"185559",title:"Dr.",name:"Yuan-Chuan",middleName:null,surname:"Chen",slug:"yuan-chuan-chen",fullName:"Yuan-Chuan Chen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:16,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"65601",doi:"10.5772/intechopen.84455",title:"Epigenetic Modifications in Plants under Abiotic Stress",slug:"epigenetic-modifications-in-plants-under-abiotic-stress",totalDownloads:1572,totalCrossrefCites:13,totalDimensionsCites:17,abstract:"Plants face a plethora of biotic and abiotic stresses ranging from extreme temperatures to salinity, drought, nutritional deficiencies, chemical toxicity, and pathogen attacks. As a consequence, plants have acquired several sophisticated regulatory mechanisms that allow them to cope with such adverse conditions. Epigenetic regulation plays a key role in the mechanisms of plant response to the environment, without altering DNA sequences. Epigenetics refers to heritable alterations in chromatin architecture that do not involve changes in the underlying DNA sequence but alter gene expression through DNA methylation or histone modifications. The epigenetic regulation of the plant genome is a highly dynamic process that fine-tunes the expression of a pertinent set of genes under certain environmental or developmental conditions. Over the past two decades rapid advancements in the field of high throughput sequencing unveil epigenetic information at genome wide level in various plant species. In view of the adverse effects of global climatic change, utilizing epigenetic differences for developing improved crop varieties is of paramount importance.",book:{id:"7995",slug:"epigenetics",title:"Epigenetics",fullTitle:"Epigenetics"},signatures:"Garima Singroha and Pradeep Sharma",authors:[{id:"142882",title:"Dr.",name:"Pradeep",middleName:null,surname:"Sharma",slug:"pradeep-sharma",fullName:"Pradeep Sharma"},{id:"281215",title:"Dr.",name:"Garima",middleName:null,surname:"Singroha",slug:"garima-singroha",fullName:"Garima Singroha"}]},{id:"64908",doi:"10.5772/intechopen.82738",title:"Therapeutic Implication of miRNA in Human Disease",slug:"therapeutic-implication-of-mirna-in-human-disease",totalDownloads:1520,totalCrossrefCites:7,totalDimensionsCites:16,abstract:"MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that are involved in development and diseases. Early studies are focusing on the miRNA profile as a biomarker in disease. As discovery of human miRNAs increased in the setting of disease, the research focus was gradually shifted towards miRNA therapeutic strategy for diagnostic and treatment of disease. Increasing evidences suggest that miRNAs are the next important class of antisense therapeutic molecules, which have significant advantage over antisense such as siRNAs because miRNAs are naturally occurring endogenous molecules. Aberrant alteration of the endogenous miRNAs has been linked to the development of certain diseases. Correcting these altered miRNAs by their mimics or inhibitors has been developed as potential therapeutic approaches. Some of the miRNA-based therapeutics are processed in preclinical and clinical trial for treatment hepatitis C, liver cancer, and other diseases. Currently, the major focus in the development of miRNA-based therapeutics is how to increase the miRNA stability and optimize delivery systems for specific disease with minimal off-target effect. This chapter will first overview the miRNA biogenesis, patho- and physiologic function, and regulation of miRNA molecules. Then, we discuss the miRNA-based potential therapeutic approaches and implication in disease.",book:{id:"6987",slug:"antisense-therapy",title:"Antisense Therapy",fullTitle:"Antisense Therapy"},signatures:"Andrew Walayat, Meizi Yang and DaLiao Xiao",authors:[{id:"188957",title:"Dr.",name:"DaLiao",middleName:null,surname:"Xiao",slug:"daliao-xiao",fullName:"DaLiao Xiao"},{id:"269866",title:"Ph.D. Student",name:"Andrew",middleName:null,surname:"Walayat",slug:"andrew-walayat",fullName:"Andrew Walayat"},{id:"283826",title:"Dr.",name:"Meizi",middleName:null,surname:"Yang",slug:"meizi-yang",fullName:"Meizi Yang"}]},{id:"32799",doi:"10.5772/33525",title:"GC3 Biology in Eukaryotes and Prokaryotes",slug:"gc3-biology-in-eukaryotes-and-prokaryotes",totalDownloads:1985,totalCrossrefCites:7,totalDimensionsCites:15,abstract:null,book:{id:"1723",slug:"dna-methylation-from-genomics-to-technology",title:"DNA Methylation",fullTitle:"DNA Methylation - From Genomics to Technology"},signatures:"Eran Elhaik and Tatiana Tatarinova",authors:[{id:"95992",title:"Dr.",name:"Tatiana",middleName:"Valerievna",surname:"Tatarinova",slug:"tatiana-tatarinova",fullName:"Tatiana Tatarinova"},{id:"105570",title:"Dr.",name:"Eran",middleName:null,surname:"Elhaik",slug:"eran-elhaik",fullName:"Eran Elhaik"}]},{id:"63488",doi:"10.5772/intechopen.80874",title:"Nontransformative Strategies for RNAi in Crop Protection",slug:"nontransformative-strategies-for-rnai-in-crop-protection",totalDownloads:2054,totalCrossrefCites:5,totalDimensionsCites:13,abstract:"RNAi in crop protection can be achieved not only by plant-incorporated protectants through plant transformation (transgenic) but also by nontransformative strategies such as formulations of sprayable dsRNAs used as direct control agents, resistance factor repressors, or developmental disruptors. Therefore, the RNAi-based biopesticides are expected to reach the market also in the form of nontransgenic strategies such as sprayable products, stem injection, root drenching, seed treatment, or powder/granule. While the delivery of dsRNA by transgenic expression is well established, it requires generations of crop plants and is costly, which may take years and delays for practical application, depending on the regulatory rules, plant transformability, genetic stability, and public acceptance of genetically modified crop species. DsRNA delivery as a nontransgenic approach was already published as a proof-of-concept work, so it is time to point out some directions on how the real potential for agriculture and crop protection is.",book:{id:"7331",slug:"modulating-gene-expression-abridging-the-rnai-and-crispr-cas9-technologies",title:"Modulating Gene Expression",fullTitle:"Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies"},signatures:"Deise Cagliari, Ericmar Avila dos Santos, Naymã Dias, Guy Smagghe\nand Moises Zotti",authors:null},{id:"65775",doi:"10.5772/intechopen.84628",title:"The Role of DNA Repair in Cellular Aging Process",slug:"the-role-of-dna-repair-in-cellular-aging-process",totalDownloads:1277,totalCrossrefCites:3,totalDimensionsCites:11,abstract:"Aging is defined as the time-dependent decline of functional properties. One common denominator of aging is mitochondrial dysfunction and accumulation of genetic damage throughout life. In fact, the imperfect maintenance of nuclear and mitochondrial DNA likely represents a critical contributor of aging. Each day, the integrity and stability of DNA are challenged by exogenous physical, chemical, or biological agents, as well as by endogenous processes, including DNA replication mistakes, spontaneous hydrolytic reactions, and reactive oxygen species. In this way, DNA repair systems have evolved a complex network that is collectively able of dealing with most of the damages inflicted. However, their efficiency may decrease with age and, therefore, influence the rate of aging. Thus, the purpose of this work is to summarize the recent knowledge in cellular aging process and its link with DNA repair systems, with a particular emphasis on the molecular mechanisms associated.",book:{id:"8605",slug:"dna-repair-an-update",title:"DNA Repair",fullTitle:"DNA Repair- An Update"},signatures:"Francisco Alejandro Lagunas-Rangel and Rosa María Bermúdez-Cruz",authors:[{id:"205238",title:"Dr.",name:"Rosa",middleName:null,surname:"Bermudez",slug:"rosa-bermudez",fullName:"Rosa Bermudez"},{id:"287111",title:"MSc.",name:"Francisco-Alejandro",middleName:null,surname:"Lagunas-Rangel",slug:"francisco-alejandro-lagunas-rangel",fullName:"Francisco-Alejandro Lagunas-Rangel"}]}],mostDownloadedChaptersLast30Days:[{id:"69649",title:"Introductory Chapter: Gene Expression and Phenotypic Traits",slug:"introductory-chapter-gene-expression-and-phenotypic-traits",totalDownloads:1242,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"8992",slug:"gene-expression-and-phenotypic-traits",title:"Gene Expression and Phenotypic Traits",fullTitle:"Gene Expression and Phenotypic Traits"},signatures:"Yuan-Chuan Chen",authors:[{id:"185559",title:"Dr.",name:"Yuan-Chuan",middleName:null,surname:"Chen",slug:"yuan-chuan-chen",fullName:"Yuan-Chuan Chen"}]},{id:"66368",title:"Introductory Chapter: Gene Editing Technologies and Applications",slug:"introductory-chapter-gene-editing-technologies-and-applications",totalDownloads:1152,totalCrossrefCites:0,totalDimensionsCites:3,abstract:null,book:{id:"8891",slug:"gene-editing-technologies-and-applications",title:"Gene Editing",fullTitle:"Gene Editing - Technologies and Applications"},signatures:"Yuan-Chuan Chen",authors:[{id:"185559",title:"Dr.",name:"Yuan-Chuan",middleName:null,surname:"Chen",slug:"yuan-chuan-chen",fullName:"Yuan-Chuan Chen"}]},{id:"64290",title:"Strand Displacement Amplification for Multiplex Detection of Nucleic Acids",slug:"strand-displacement-amplification-for-multiplex-detection-of-nucleic-acids",totalDownloads:2177,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"The identification of various targets such as bacteria, viruses, and other cells remains a prerequisite for point-of-care diagnostics and biotechnological applications. Nucleic acids, as encoding information for all forms of life, are excellent biomarkers for detecting pathogens, hereditary diseases, and cancers. To date, many techniques have been developed to detect nucleic acids. However, most of them are based on polymerase chain reaction (PCR) technology. These methods are sensitive and robust, but they require expensive instruments and trained personnel. DNA strand displacement amplification is carried out under isothermal conditions and therefore does not need expensive instruments. It is simple, fast, sensitive, specific, and inexpensive. In this chapter, we introduce the principles, methods, and updated applications of DNA strand displacement technology in the detection of infectious diseases. We also discuss how robust, sensitive, and specific nucleic acid detection could be obtained when combined with the novel CRISPR/Cas system.",book:{id:"7331",slug:"modulating-gene-expression-abridging-the-rnai-and-crispr-cas9-technologies",title:"Modulating Gene Expression",fullTitle:"Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies"},signatures:"Lingwen Zeng, Omar Mukama, Xuewen Lu, Shilin Cao and Donghai\nLin",authors:null},{id:"63557",title:"Molecular Identification of Genetically Modified Crops for Biosafety and Legitimacy of Transgenes",slug:"molecular-identification-of-genetically-modified-crops-for-biosafety-and-legitimacy-of-transgenes",totalDownloads:1993,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Crops undergo artificially DNA modifications for improvements are considered as genetically modified (GM) crops. These modifications could be in indigenous DNA or by introduction of foreign DNA as transgenes. There are 29 different crops and fruit trees in 42 countries, which have been successfully modified for various traits like herbicide tolerance, insect/pest resistance, disease resistance and quality improvement. GM crops are grown worldwide and its area is significantly increasing every year. Many countries have very strict rules and regulations for GM crops and are also a trade barrier in some situations. Hence, identification and testing of crops for GM contents is important for identity and legitimacy of transgene to simplify the international trade. Normally, molecular identification is performed at three different levels, i.e., DNA, RNA and protein, and each level has its own importance in testing about the nature and type of GM crops. In this chapter, current scenario of GM crops and different molecular testing tools are described in brief.",book:{id:"8891",slug:"gene-editing-technologies-and-applications",title:"Gene Editing",fullTitle:"Gene Editing - Technologies and Applications"},signatures:"Shahid Nazir, Muhammad Zaffar Iqbal and Sajid-ur-Rahman",authors:null},{id:"38872",title:"Repetitive DNA: A Tool to Explore Animal Genomes/Transcriptomes",slug:"repetitive-dna-a-tool-to-explore-animal-genomes-transcriptomes",totalDownloads:4690,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"2748",slug:"functional-genomics",title:"Functional Genomics",fullTitle:"Functional Genomics"},signatures:"Deepali Pathak and Sher Ali",authors:[{id:"33032",title:"Dr.",name:"Sher",middleName:null,surname:"Ali",slug:"sher-ali",fullName:"Sher Ali"},{id:"141455",title:"Dr.",name:"Deepali",middleName:null,surname:"Pathak",slug:"deepali-pathak",fullName:"Deepali Pathak"}]}],onlineFirstChaptersFilter:{topicId:"53",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81708",title:"High Throughput Methods to Transfer DNA in Cells and Perspectives",slug:"high-throughput-methods-to-transfer-dna-in-cells-and-perspectives",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.104542",abstract:"Genome sequencing led to thousands of genes to study and their molecular cloning to provide ORF collection plasmids. The main approach to study their function involves analysis of the biological consequences of their expression or knockdown, in a cellular context. Given that, the starting point of such experiments is the delivery of the exogenous material, including plasmid DNA in cells. During the last decades, efforts were made to develop efficient methods and protocols to achieve this goal. The present chapter will first give a rapid overview of the main DNA transfer methods described so far: physical, chemical, and biological. Secondly, it will focus on the different methods having reached high-throughput nowadays. Finally, it will discuss the perspectives of this field in terms of future enhancements.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Colin Béatrice and Couturier Cyril"},{id:"81720",title:"Genetic Transformation in Prokaryotic and Eukaryotic Cells",slug:"genetic-transformation-in-prokaryotic-and-eukaryotic-cells",totalDownloads:27,totalDimensionsCites:0,doi:"10.5772/intechopen.103839",abstract:"Improving the quality and quantity of an organism and its products can be approached by molecular characters enhancement through the insertion of a gene of interest into cells of the desired organism. Genetic transformation of an organism involves isolation, identification, cloning a gene of interest into a vector, and transferring the gene to the target organism. This chapter reviews the process of genetic transformation into the organism’s cell from bacterial (Escherichia coli), yeast, plant (Onion, Tobacco, and Orchids), and mammalian. The discussion will be focused on the introduction of DNA molecules into plant cells and protoplast mediated by polyethylene glycol (PEG), electroporation, and gene gun using particle bombardment. Further discussion on the transient protein expression system of plant-based on protoplast, onion cell, and tobacco will also be covered in this chapter as well. The systems have been proven as a powerful tool for determining subcellular protein localization, protein-protein interactions, identifying gene function, and regulation. Finally, it can be clearly seen, the differences and similarities in the mechanism of genetic transformation both in prokaryotic and eukaryotic systems.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Endang Semiarti, Yekti Asih Purwestri, Saifur Rohman and Wahyu Aristyaning Putri"},{id:"81647",title:"Diabetes and Epigenetics",slug:"diabetes-and-epigenetics",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.104653",abstract:"As we attempt to understand and treat diseases, the field of epigenetics is receiving increased attention. For example, epigenetic changes may contribute to the etiology of diabetes. Herein, we review the histology of the pancreas, sugar metabolism and insulin signaling, the different types of diabetes, and the potential role of epigenetic changes, such as DNA methylation, in diabetes etiology. These epigenetic changes occur at differentially-methylated sites or regions and have been previously linked to metabolic diseases such as obesity. In particular, changes in DNA methylation in cells of the pancreatic islets of Langerhans may be linked to type 2 diabetes (T2D), which in turn is related to peripheral insulin resistance that may increase the severity of the disease. The hypothesis is that changes in the epigenome may provide an underlying molecular mechanism for the cause and deleterious metabolic health outcomes associated with severe obesity or T2D. Conversely, reversing such epigenetic changes may help improve metabolic health after therapeutic interventions.",book:{id:"9672",title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg"},signatures:"Rasha A. Alhazzaa, Thomas Heinbockel and Antonei B. Csoka"},{id:"81604",title:"Nonribosomal Peptide Synthesis",slug:"nonribosomal-peptide-synthesis",totalDownloads:31,totalDimensionsCites:0,doi:"10.5772/intechopen.104722",abstract:"Nonribosomal peptides (NRPs) are a type of secondary metabolite with a wide range of pharmacological and biological activities including cytostatics, immunosuppressants or anticancer agents, antibiotics, pigments, siderophores, toxins. NRPs, unlike other proteins, are synthesized on huge nonribosomal peptide synthetase (NRPS) enzyme complexes that are not dependent on ribosomal machinery. Bacteria and fungi are the most common NRPs producers. Furthermore, the presence of these peptides has been confirmed in marine microbes. Nowadays, many of these peptides are used in the treatments of inflammatory, cancer, neurodegenerative disorders, and infectious disease for the development of new therapeutic agents. The structure, function, and synthesis of NRPs, as well as producer microorganisms and their several application areas, are covered in this chapter.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Sadık Dincer, Hatice Aysun Mercimek Takci and Melis Sumengen Ozdenefe"},{id:"81051",title:"CRISPR Technology: Emerging Tools of Genome Editing and Protein Detection",slug:"crispr-technology-emerging-tools-of-genome-editing-and-protein-detection",totalDownloads:30,totalDimensionsCites:0,doi:"10.5772/intechopen.102516",abstract:"CRISPR technology has seen rapid development in applications ranging from genomic and epigenetic changes to protein identification throughout the last decade. The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) protein systems have transformed the ability to edit, control the genomic nucleic acid and non-nucleic acid target such as detection of proteins. CRISPR/Cas systems are RNA-guided endonucleases exhibiting distinct cleavage activities deployed in the development of analytical techniques. Apart from genome editing technology, CRISPR/Cas has also been incorporated in amplified detection of proteins, transcriptional modulation, cancer biomarkers, and rapid detection of POC (point of care) diagnostics for various diseases such as Covid-19. Current protein detection methods incorporate sophisticated instrumentation and extensive sensing procedures with less reliable, quantitative, and sensitive detection of proteins. The precision and sensitivity brought in by CRISPR-dependent detection of proteins will ensure the elimination of current impediments. CRISPR-based amplification strategies have been used for accurate estimation of proteins including aptamer-based assay, femtomolar detection of proteins in living cells, immunoassays, and isothermal proximal assay for high throughput. The chapter will provide a comprehensive summary of key developments in emerging tools of genome editing and protein detection deploying CRISPR technology, and its future perspectives will be discussed.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Rita Lakkakul and Pradip Hirapure"},{id:"80374",title:"Viral Vectors in Gene Therapy and Clinical Applications",slug:"viral-vectors-in-gene-therapy-and-clinical-applications",totalDownloads:34,totalDimensionsCites:0,doi:"10.5772/intechopen.102559",abstract:"Developments in gene therapy, coupled with advances in genome sequencing and a greater understanding of DNA sequences, have given rise to an exciting area of research. The use of viral vectors in gene therapy has become a very promising and fast-emerging technology over the past few decades. Despite previous setbacks, the approval of viral vector therapies worldwide, with many in late-stage clinical trials has led to a significant increase in research in this area of gene therapy. Retroviral, adenoviral, adeno-associated viral, and lentiviral vectors are all key vectors currently being researched and used in clinical trials. There are many challenges with the use of viral vectors that are yet to be overcome including cost of production, the immune response, and the ability to precisely regulate the expression of the transgene. However, with increased numbers of clinical trials showing efficacy, safety, and growing financial investment, the future use of viral vectors in gene therapy is increasingly promising.",book:{id:"11356",title:"Molecular Cloning",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg"},signatures:"Alexandra L.G. Mahoney, Najah T. Nassif, Bronwyn A. O’Brien and Ann M. Simpson"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:6,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:17,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"22",title:"Business, Management and Economics",doi:"10.5772/intechopen.100359",issn:"2753-894X",scope:"
\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. Topics will include asset liability management, financial consequences of the financial crisis and covid-19, financial accounting, mergers and acquisitions, management accounting, SMEs, financial markets, corporate finance and governance, managerial technology and innovation, resource management and sustainable development, social entrepreneurship, corporate responsibility, ethics and accountability, microeconomics, labour economics, macroeconomics, public economics, financial economics, econometrics, direct marketing, creative marketing, internet marketing, market planning and forecasting, brand management, market segmentation and targeting and other topics under business and management. This book series will focus on various aspects of business and management whose in-depth understanding is critical for business and company management to function effectively during this uncertain time of financial crisis, Covid-19 pandemic, and military activity in Europe.
",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"June 27th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. He has published more than 400 works in his academic career and visited twenty-two universities worldwide as a visiting professor. Dr. Bobek is a member of the editorial boards of six international journals and a member of the Strategic Council of the Minister of Foreign Affairs of the Republic of Slovenia. He has a long history in academia, consulting, and entrepreneurship. His own consulting firm, Palemid, has managed twenty significant projects, such as Cooperation Program Interreg V-A (Slovenia-Austria) and Capacity Building for the Serbian Chamber of Enforcement Agents. He has also participated in many international projects in Italy, Germany, Great Britain, the United States, Spain, Turkey, France, Romania, Croatia, Montenegro, Malaysia, and China. Dr. Bobek is also a co-founder of the Academy of Regional Management in Slovenia.",institutionString:"Universities of Applied Sciences FH Joanneum, Austria",institution:{name:"Universities of Applied Sciences Joanneum",institutionURL:null,country:{name:"Austria"}}},editorTwo:{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",slug:"tatjana-horvat",fullName:"Tatjana Horvat",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hXb0hQAC/Profile_Picture_1642419002203",biography:"Tatjana Horvat works as a professor for accountant and auditing at the University of Primorska, Slovenia. She is a Certified State Internal Auditor (licensed by Ministry of Finance RS) and Certified Internal Auditor for Business Sector and Certified accountant (licensed by Slovenian Institute of Auditors). At the Ministry of Justice of Slovenia, she is a member of examination boards for court expert candidates and judicial appraisers in the following areas: economy/finance, valuation of companies, banking, and forensic investigation of economic operations/accounting. At the leading business newspaper Finance in Slovenia (Swedish ownership), she is the editor and head of the area for business, finance, tax-related articles, and educational programs.",institutionString:null,institution:{name:"University of Primorska",institutionURL:null,country:{name:"Slovenia"}}},editorThree:null},{id:"87",title:"Economics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/87.jpg",isOpenForSubmission:!0,editor:{id:"327730",title:"Prof.",name:"Jaime",middleName:null,surname:"Ortiz",slug:"jaime-ortiz",fullName:"Jaime Ortiz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002zaOKZQA2/Profile_Picture_1642145584421",biography:"Dr. Jaime Ortiz holds degrees from Chile, the Netherlands, and the United States. He has held tenured faculty, distinguished professorship, and executive leadership appointments in several universities around the world. Dr. Ortiz has previously worked for international organizations and non-government entities in economic and business matters, and he has university-wide globalization engagement in more than thirty-six countries. He has advised, among others, the United Nations Development Program, Inter-American Development Bank, Organization of American States, Pre-investment Organization of Latin America and the Caribbean, Technical Cooperation of the Suisse Government, and the World Bank. Dr. Ortiz is the author, co-author, or editor of books, book chapters, textbooks, research monographs and technical reports, and refereed journal articles. He is listed in Who’s Who in the World, Who’s Who in America, Who’s Who in Finance and Business, Who’s Who in Business Higher Education, Who’s Who in American Education, and Who’s Who Directory of Economists. Dr. Ortiz has been a Fulbright Scholar and an MSI Leadership Fellow with the W.K. Kellogg Foundation. His teaching interests revolve around global economies and markets while his research focuses on topics related to development and growth, global business decisions, and the economics of technical innovation.",institutionString:null,institution:{name:"University of Houston",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},{id:"88",title:"Marketing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/88.jpg",isOpenForSubmission:!0,editor:{id:"203609",title:"Associate Prof.",name:"Hanna",middleName:null,surname:"Gorska-Warsewicz",slug:"hanna-gorska-warsewicz",fullName:"Hanna Gorska-Warsewicz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSD9pQAG/Profile_Picture_2022-06-14T11:58:32.jpeg",biography:"Hanna Górska-Warsewicz, Ph.D. is Associate Professor at Warsaw University of Life Sciences and Head of Department of Food Market and Consumption Research. She specializes in the subject of brands, brand equity, and brand management in production, service, and trade enterprises. She combines this subject with marketing and marketing management in both theoretical and practical aspects. Prof. Hanna Górska-Warsewicz also analyzes brands in the context of trademarks, legal regulations and the protection of intangible. She is an author or co-author of over 200 publications in this field, including 8 books. She works with the business sector and has participated in projects for the Ministry of Agriculture and Rural Development and the Ministry of Education and Science in Poland.",institutionString:null,institution:{name:"Warsaw University of Life Sciences",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:8,paginationItems:[{id:"82289",title:"Consumer Culture and Abundance of Choices: Having More, Feeling Blue",doi:"10.5772/intechopen.105607",signatures:"Ondřej Roubal",slug:"consumer-culture-and-abundance-of-choices-having-more-feeling-blue",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"A New Era of Consumer Behavior - Beyond the Pandemic",coverURL:"https://cdn.intechopen.com/books/images_new/11581.jpg",subseries:{id:"88",title:"Marketing"}}},{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82395",title:"Toward a Better Understanding of Green Human Resource Management’s Impact on Green Competitive Advantage: A Conceptual Model",doi:"10.5772/intechopen.105528",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"toward-a-better-understanding-of-green-human-resource-management-s-impact-on-green-competitive-advan",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82269",title:"CSR Reporting and Blockchain Technology",doi:"10.5772/intechopen.105512",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Piyachart Phiromswad",slug:"csr-reporting-and-blockchain-technology",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}}]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:8,paginationItems:[{id:"11662",title:"Limnology - The Importance of Monitoring and Correlations of Lentic and Lotic Waters",coverURL:"https://cdn.intechopen.com/books/images_new/11662.jpg",hash:"f1043cf6b1daae7a7b527e1d162ca4a8",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"315689",title:"Dr.",name:"Carmine",surname:"Massarelli",slug:"carmine-massarelli",fullName:"Carmine Massarelli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11665",title:"Recent Advances in Wildlife Management",coverURL:"https://cdn.intechopen.com/books/images_new/11665.jpg",hash:"73da0df494a1a56ab9c4faf2ee811899",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 25th 2022",isOpenForSubmission:!0,editors:[{id:"75563",title:"Dr.",name:"Farzana Khan",surname:"Perveen",slug:"farzana-khan-perveen",fullName:"Farzana Khan Perveen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11666",title:"Soil Contamination - Recent Advances and Future Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11666.jpg",hash:"c8890038b86fb6e5af16ea3c22669ae9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 9th 2022",isOpenForSubmission:!0,editors:[{id:"299110",title:"Dr.",name:"Adnan",surname:"Mustafa",slug:"adnan-mustafa",fullName:"Adnan Mustafa"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",hash:"727e7eb3d4ba529ec5eb4f150e078523",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 22nd 2022",isOpenForSubmission:!0,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12222",title:"Advances and Challenges in Microplastics",coverURL:"https://cdn.intechopen.com/books/images_new/12222.jpg",hash:"a36734a551e0997d2255f6ce99eff818",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 1st 2022",isOpenForSubmission:!0,editors:[{id:"347657",title:"Prof.",name:"El-Sayed",surname:"Salama",slug:"el-sayed-salama",fullName:"El-Sayed Salama"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11650",title:"Aquifers - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11650.jpg",hash:"27c1a2a053cb1d83de903c5b969bc3a2",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 12th 2022",isOpenForSubmission:!0,editors:[{id:"271093",title:"Dr.",name:"Abhay",surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12223",title:"Sustainable Management of Natural Resources",coverURL:"https://cdn.intechopen.com/books/images_new/12223.jpg",hash:"1881a08bbd8f5dc1102c5cb7c635bc35",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 19th 2022",isOpenForSubmission:!0,editors:[{id:"144417",title:"Dr.",name:"Mohd Nazip",surname:"Suratman",slug:"mohd-nazip-suratman",fullName:"Mohd Nazip Suratman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11668",title:"Mercury Pollution",coverURL:"https://cdn.intechopen.com/books/images_new/11668.jpg",hash:"0bd111f57835089cad4a9741326dbab7",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 22nd 2022",isOpenForSubmission:!0,editors:[{id:"196849",title:"Dr.",name:"Ahmed",surname:"Abdelhafez",slug:"ahmed-abdelhafez",fullName:"Ahmed Abdelhafez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:6,paginationItems:[{id:"81909",title:"Educational Paradigm with Ubuntu Mindset: Implications for Sustainable Development Goals in Education",doi:"10.5772/intechopen.104929",signatures:"George Frempong and Raavee Kadam",slug:"educational-paradigm-with-ubuntu-mindset-implications-for-sustainable-development-goals-in-education",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82394",title:"Learning by Doing Active Social Learning",doi:"10.5772/intechopen.105523",signatures:"Anat Raviv",slug:"learning-by-doing-active-social-learning",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82310",title:"Knowledge of Intergenerational Contact to Combat Ageism towards Older People",doi:"10.5772/intechopen.105592",signatures:"Alice Nga Lai Kwong",slug:"knowledge-of-intergenerational-contact-to-combat-ageism-towards-older-people",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11479.jpg",subseries:{id:"90",title:"Human Development"}}},{id:"81993",title:"Emergent Chemistry: Using Visualizations to Develop Abstract Thinking and a Sense of Scale Within the Preschool Setting",doi:"10.5772/intechopen.105216",signatures:"Karina Adbo",slug:"emergent-chemistry-using-visualizations-to-develop-abstract-thinking-and-a-sense-of-scale-within-the",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82252",title:"Early Childhood: Enriched Environments and Roles of Caring Adults",doi:"10.5772/intechopen.105157",signatures:"Analía Mignaton",slug:"early-childhood-enriched-environments-and-roles-of-caring-adults",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"81996",title:"Perspective Chapter: New Active Learning Models in Africa",doi:"10.5772/intechopen.105217",signatures:"Fred Awaah, Cosmas Lambini Kombat and Emmanuel Okyere Ekwam",slug:"perspective-chapter-new-active-learning-models-in-africa",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}}]},subseriesFiltersForOFChapters:[{caption:"Human Development",value:90,count:1,group:"subseries"},{caption:"Education",value:89,count:5,group:"subseries"}],publishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"10664",title:"Animal Reproduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",slug:"animal-reproduction",publishedDate:"May 25th 2022",editedByType:"Edited by",bookSignature:"Yusuf Bozkurt and Mustafa Numan Bucak",hash:"2d66af42fb17d0a6556bb9ef28e273c7",volumeInSeries:11,fullTitle:"Animal Reproduction",editors:[{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",slug:"animal-feed-science-and-nutrition-production-health-and-environment",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Amlan Kumar Patra",hash:"79944fc8fbbaa329aed6fde388154832",volumeInSeries:10,fullTitle:"Animal Feed Science and Nutrition - Production, Health and Environment",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",slug:"rabies-virus-at-the-beginning-of-21st-century",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Sergey Tkachev",hash:"49cce3f548da548c718c865feb343509",volumeInSeries:9,fullTitle:"Rabies Virus at the Beginning of 21st Century",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",institutionURL:null,country:{name:"Russia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10496",title:"Advanced Studies in the 21st Century Animal Nutrition",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10496.jpg",slug:"advanced-studies-in-the-21st-century-animal-nutrition",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"László Babinszky, Juliana Oliveira and Edson Mauro Santos",hash:"8ffe43a82ac48b309abc3632bbf3efd0",volumeInSeries:8,fullTitle:"Advanced Studies in the 21st Century Animal Nutrition",editors:[{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",slug:"canine-genetics-health-and-medicine",publishedDate:"June 2nd 2021",editedByType:"Edited by",bookSignature:"Catrin Rutland",hash:"b91512e31ce34032e560362e6cbccc1c",volumeInSeries:7,fullTitle:"Canine Genetics, Health and Medicine",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8545",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",slug:"animal-reproduction-in-veterinary-medicine",publishedDate:"January 20th 2021",editedByType:"Edited by",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",hash:"13aaddf5fdbbc78387e77a7da2388bf6",volumeInSeries:6,fullTitle:"Animal Reproduction in Veterinary Medicine",editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",institutionString:"Independent Researcher",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9081",title:"Equine Science",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",slug:"equine-science",publishedDate:"September 23rd 2020",editedByType:"Edited by",bookSignature:"Catrin Rutland and Albert Rizvanov",hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",volumeInSeries:5,fullTitle:"Equine Science",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8460",title:"Reproductive Biology and Technology in Animals",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8460.jpg",slug:"reproductive-biology-and-technology-in-animals",publishedDate:"April 15th 2020",editedByType:"Edited by",bookSignature:"Juan Carlos Gardón Poggi and Katy Satué Ambrojo",hash:"32ef5fe73998dd723d308225d756fa1e",volumeInSeries:4,fullTitle:"Reproductive Biology and Technology in Animals",editors:[{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8524",title:"Lactation in Farm Animals",subtitle:"Biology, Physiological Basis, Nutritional Requirements, and Modelization",coverURL:"https://cdn.intechopen.com/books/images_new/8524.jpg",slug:"lactation-in-farm-animals-biology-physiological-basis-nutritional-requirements-and-modelization",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Naceur M'Hamdi",hash:"2aa2a9a0ec13040bbf0455e34625504e",volumeInSeries:3,fullTitle:"Lactation in Farm Animals - Biology, Physiological Basis, Nutritional Requirements, and Modelization",editors:[{id:"73376",title:"Dr.",name:"Naceur",middleName:null,surname:"M'Hamdi",slug:"naceur-m'hamdi",fullName:"Naceur M'Hamdi",profilePictureURL:"https://mts.intechopen.com/storage/users/73376/images/system/73376.jpg",institutionString:null,institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7144",title:"Veterinary Anatomy and Physiology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",slug:"veterinary-anatomy-and-physiology",publishedDate:"March 13th 2019",editedByType:"Edited by",bookSignature:"Catrin Sian Rutland and Valentina Kubale",hash:"75cdacb570e0e6d15a5f6e69640d87c9",volumeInSeries:2,fullTitle:"Veterinary Anatomy and Physiology",editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7233",title:"New Insights into Theriogenology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7233.jpg",slug:"new-insights-into-theriogenology",publishedDate:"December 5th 2018",editedByType:"Edited by",bookSignature:"Rita Payan-Carreira",hash:"74f4147e3fb214dd050e5edd3aaf53bc",volumeInSeries:1,fullTitle:"New Insights into Theriogenology",editors:[{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Animal Nutrition",value:20,count:2},{group:"subseries",caption:"Animal Reproductive Biology and Technology",value:28,count:4},{group:"subseries",caption:"Animal Science",value:19,count:5}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:1},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:303,paginationItems:[{id:"313921",title:"Dr.",name:"Hassan M.",middleName:null,surname:"Heshmati",slug:"hassan-m.-heshmati",fullName:"Hassan M. Heshmati",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313921/images/system/313921.jpg",biography:"Dr. Hassan Massoud Heshmati is an endocrinologist with 46 years of experience in clinical research in academia (university-affiliated hospitals, Paris, France; Mayo Foundation, Rochester, MN, USA) and pharmaceutical companies (Sanofi, Malvern, PA, USA; Essentialis, Carlsbad, CA, USA; Gelesis, Boston, MA, USA). His research activity focuses on pituitary tumors, hyperthyroidism, thyroid cancers, osteoporosis, diabetes, and obesity. He has extensive knowledge in the development of anti-obesity products. Dr. Heshmati is the author of 299 abstracts, chapters, and articles related to endocrinology and metabolism. He is currently a consultant at Endocrinology Metabolism Consulting, LLC, Anthem, AZ, USA.",institutionString:"Endocrinology Metabolism Consulting, LLC",institution:null},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. in Chemistry in July 2000, and his Ph.D. in Physical Chemistry in 2007 from the University of Khartoum, Sudan. In 2009 he joined the Dr. Ron Clarke research group at the School of Chemistry, Faculty of Science, University of Sydney, Australia as a postdoctoral fellow where he worked on the Interaction of ATP with the phosphoenzyme of the Na+, K+-ATPase, and Dual mechanisms of allosteric acceleration of the Na+, K+-ATPase by ATP. He then worked as Assistant Professor at the Department of Chemistry, University of Khartoum, and in 2014 was promoted to Associate Professor ranking. In 2011 he joined the staff of the Chemistry Department at Taif University, Saudi Arabia, where he is currently active as an Assistant Professor. His research interests include:\r\n(1) P-type ATPase Enzyme Kinetics and Mechanisms; (2) Kinetics and Mechanism of Redox Reactions; (3) Autocatalytic reactions; (4) Computational enzyme kinetics; (5) Allosteric acceleration of P-type ATPases by ATP; (6) Exploring of allosteric sites of ATPases and interaction of ATP with ATPases located in the cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, México. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 270 peer-reviewed papers, 32 book chapters, and 4 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:null,institution:null},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"428313",title:"Dr.",name:"Sambangi",middleName:null,surname:"Pratyusha",slug:"sambangi-pratyusha",fullName:"Sambangi Pratyusha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"CGIAR",country:{name:"France"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},onlineFirstChapters:{paginationCount:10,paginationItems:[{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:30,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81471",title:"Semantic Map: Bringing Together Groups and Discourses",doi:"10.5772/intechopen.103818",signatures:"Theodore Chadjipadelis and Georgia Panagiotidou",slug:"semantic-map-bringing-together-groups-and-discourses",totalDownloads:21,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79491",title:"Fuzzy Perceptron Learning for Non-Linearly Separable Patterns",doi:"10.5772/intechopen.101312",signatures:"Raja Kishor Duggirala",slug:"fuzzy-perceptron-learning-for-non-linearly-separable-patterns",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Raja Kishor",surname:"Duggirala"}],book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81331",title:"Machine Learning Algorithm-Based Contraceptive Practice among Ever-Married Women in Bangladesh: A Hierarchical Machine Learning Classification Approach",doi:"10.5772/intechopen.103187",signatures:"Iqramul Haq, Md. Ismail Hossain, Md. Moshiur Rahman, Md. Injamul Haq Methun, Ashis Talukder, Md. Jakaria Habib and Md. Sanwar Hossain",slug:"machine-learning-algorithm-based-contraceptive-practice-among-ever-married-women-in-bangladesh-a-hie",totalDownloads:21,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"80937",title:"Assessing Heterogeneity of Two-Part Model via Bayesian Model-Based Clustering with Its Application to Cocaine Use Data",doi:"10.5772/intechopen.103089",signatures:"Ye-Mao Xia, Qi-Hang Zhu and Jian-Wei Gou",slug:"assessing-heterogeneity-of-two-part-model-via-bayesian-model-based-clustering-with-its-application-t",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"78846",title:"Clustering Algorithms: An Exploratory Review",doi:"10.5772/intechopen.100376",signatures:"R.S.M. Lakshmi Patibandla and Veeranjaneyulu N",slug:"clustering-algorithms-an-exploratory-review",totalDownloads:146,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"78463",title:"Clustering by Similarity of Brazilian Legal Documents Using Natural Language Processing Approaches",doi:"10.5772/intechopen.99875",signatures:"Raphael Souza de Oliveira and Erick Giovani Sperandio Nascimento",slug:"clustering-by-similarity-of-brazilian-legal-documents-using-natural-language-processing-approaches",totalDownloads:157,totalCrossrefCites:1,totalDimensionsCites:1,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},publishedBooks:{paginationCount:7,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Dr.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:null,institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6667",title:"Influenza",subtitle:"Therapeutics and Challenges",coverURL:"https://cdn.intechopen.com/books/images_new/6667.jpg",slug:"influenza-therapeutics-and-challenges",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"105e347b2d5dbbe6b593aceffa051efa",volumeInSeries:1,fullTitle:"Influenza - Therapeutics and Challenges",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:6,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:17,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"7",title:"Bioinformatics and Medical Informatics",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine"},{id:"8",title:"Bioinspired Technology and Biomechanics",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation"},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/71158",hash:"",query:{},params:{id:"71158"},fullPath:"/chapters/71158",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()