\r\n\tIn the last decades, particular attention to this field has been paid to the coastal erosion problem all over the world. Indeed, the deployment of artificial reservoirs, modification of the runoff characteristics of internal areas, sand extraction from rivers, and harbor siltation, caused a decrease of sediment input on the coastal environments, and, therefore, a generalized deficit in the sediment budget. Often, dredging activities are required to collect sediment finalized to “soft” techniques to restore beaches or to move the sand trapped in the harbor (clean or contaminated).
\r\n\tMoreover, the coastal protections induced hydrodynamics and morphodynamics modifications inducing sometimes strong variations to the sediment transport regime.
\r\n\tHistorically, all these aspects are related to specific research areas ranging from engineering, geology, geomorphology, biology, etc, but it is difficult to find a comprehensive overview of these topics.
\r\n\r\n\tThis book is intended to collect original works and review concerning numerical and experimental investigation, theoretical works, methodological approaches, and any other technique that allow giving the actual state-of-the-art in the field of sediment transport.
",isbn:"978-1-80355-868-4",printIsbn:"978-1-80355-867-7",pdfIsbn:"978-1-80355-869-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"e7b1c1592e32fe87af399022616ad0f8",bookSignature:"Dr. Davide Pasquali",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11136.jpg",keywords:"Longshore Sediment Transport, Sediment Budget, Morphodynamics, Hydrodynamics, Sediment Transport, Sedimentation, Mathematical Modelling, Erosion and Deposition, Dredging, Harbor Siltation, Contaminated Sediment, Water Quality",numberOfDownloads:50,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 4th 2021",dateEndSecondStepPublish:"February 23rd 2022",dateEndThirdStepPublish:"April 24th 2022",dateEndFourthStepPublish:"July 13th 2022",dateEndFifthStepPublish:"September 11th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Davide Pasquali is currently a Research Fellow in the Department of Civil, Construction-Architectural, and Environmental Engineering (DICEAA) at the University of L’Aquila. 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The facies distribution and the corresponding changes are strongly influenced by several control factors, including the sedimentary processes, the sediment supply, the climate, the tectonics, the sea level changes, the biological activity, the water chemistry, and the volcanism. In different depositional environments, these control factors are of variable importance, but the climate and the structural setting act on the whole sedimentary environments. On the other side, the sedimentary processes are critical in deltaic and fluvial environments. On the continental margins, relative sea level fluctuations involve the shallow seas and the shorelines, more than in the continental and deep marine environments, also if their effects are not negligible [1, 2, 3, 4]. In a given depositional environment, the sedimentary processes, represented by the processes intrinsic to sedimentation, are responsible for the facies distribution and change. For instance, the progradation of the distributary channels of a delta controls a decrease of the gradient, so that the river has a short route, starting a new depositional cycle. Due to the nature itself of the depositional environments, these kinds of changes are inevitable, since the timing of these changes is controlled by unusual events, such as floods, storms, or earthquakes. These trigger causes must be distinguished from the fundamental causes represented by the delta progradation [5, 6, 7], by the river aggradation, and by the slope instability [8, 9, 10]. Sediment supply represents another important control factor. Its effect depends on the sediment availability, subsidence, and relative sea level changes. In this book, the main research topics are represented by the deltas, particularly referring to the Niger Delta; by the coastal and lacustrine sedimentary archives, particularly referring to the Lake Bafa; by the riparian zone; by the beach environments and their variations during the geological time; and, finally, by the role of the mangroves in the coastal sedimentation. These topics will be outlined in the following sections.
\nThe deltas are protuberances of the shoreline, which were formed when the rivers enter the oceans, the semi-enclosed seas, the lakes, or the lagoons sheltered by barriers. They rapidly supply sediments, which can be redistributed by basinal processes. These deltas are served by drainage systems, which are well developed and culminate in a trunk stream, supplying sediments to a restricted area of the shoreline. The drainage systems produce closely spaced rivers, inducing a uniform progradation of the whole coastal plain rather than a point-concentrated progradation. The studies of the deltaic facies started in ancient successions rather than in the modern deltas with the Gilbert deltas [11, 12], describing the Pleistocene deltaic facies in Lake Bonneville. The delta has a three-dimensional structure, generating a distinctive vertical sequence of types of bedding during the delta progradation. From the lower part of the sequence to the upper part of the sequence, there is the bottomset, composed of gently inclined fine-grained sediments; the foreset, composed of beds of sands and gravels dipping from 10 to 25°; and the topset, which is composed of flat-lying gravels [11, 13]. These terms (topset, foreset, and bottomset) have been used in order to describe the delta structure and the bedding, texture, color, and fauna of each component. Although not all the deltas show a Gilbert-type structure, these concepts have conditioned the thinking on modern deltas for several decades. Therefore, the occurrence or the lack of large and inclined foresets has been considered as an important criterion for the study of deltaic successions. Moreover, the economic relevance of deltaic facies has stimulated the execution of wide borehole programs in the Mississippi, Rhone, and Niger deltas [14, 15, 16, 17, 18, 19]. These studies have shown that the deltaic successions include a variety of vertical facies and sequences and that a type of sequence within a delta varies at different locations, as well as within the deltas. The conceptual framework of the comparative studies on deltas starts from the hinterland characteristics, controlling the fluvial regime and the sediment input, which influence the delta regime (controlled also by the basinal regime), the delta morphology, and the delta facies pattern. Of course, the delta types have been defined based on the depositional regime and illustrated by a characteristic morphology.
\nThe Niger Delta is one of the most important research topics of this book. It is a large, arched delta of a destructive wave-dominated type. A succession of marine clays, overlain by paralic deposits, in turn covered by continental sands, occurs. This sequence has been built up by superimposed offlap cycles. Basement faulting has affected the development of delta and, consequently, the sediment thickness distribution. In the paralic interval, growth fault-associated rollover structures have trapped hydrocarbons. For this reason, the Niger Delta hosts main hydrocarbon reservoirs. In this case, the growth faults have functioned as hydrocarbon migration pathways from the overpressured marine clays [20].
\nThe coastal lacustrine sedimentary archives have been deeply studied, particularly referring to their use in paleoclimatic reconstructions and to the lithological and geochemical aspects [21, 22, 23, 24]. Zolitschka [21] has outlined that the lacustrine sediments have a high potential as proxies in paleoclimatic reconstructions. The annually laminated (varved) sedimentary records in a lacustrine environment represent important high-resolution archives of paleoenvironmental conditions. The most important control factor is represented by the climate and by the anthropogenic change. The linkage between the climate and the varves has been deeply studied, in particular for the proglacial lakes linked with the clastic varves (mean summer temperature, mean summer precipitation). At the middle latitudes, the varves are also controlled by the organic productivity. Moreover, the thickness of the varves may increase with the minerogenic detritus, which can be regarded as a discharge proxy. Two kinds of information have been provided, chronological and geochemical. The varve chronology has to be calibrated through other and more precise dating methods due to several misinterpretations (Holocene sediments of Skilak Lake, Alaska; Precambrian laminites, Australia). The geochemical composition of the yearly element has been calculated. The geochemical analyses have been performed on samples having a thickness of at least 1 cm, including several years or decades of deposition. Baroni et al. [22] have analyzed a core retrieved from the Lake Frassino (northern Italy), which has provided evidence of main paleohydrological changes during the last 14 ky B.P. The lake evolution has been reconstructed during the Late Glacial and the Holocene by using lithological, malacological, and isotopic composition of freshwater shells. During the Late Glacial, the conditions were drier than in the Holocene, and a wetter period has been suggested to occur before 14 ky B.P. The oxygen isotopic data have suggested a clear bipartition during Holocene times, with a dry first part (9100–7000 years B.P.), followed by an increase in humidity (7000–6800 years B.P.), while from 5000 to 2600 years, the isotopic record was characterized by large fluctuations, suggesting alternating wet and dry periods. Basilici [23] has studied the lacustrine facies of the Tiberino Basin, which was formed after Plio-Pleistocene tectonic phases of the central Italy. Four facies associations have been distinguished, consisting of the facies association A, which was deposited in a deep-offshore lacustrine environment, consisting of massive, laminated, bluish-gray marly clays and representing the main lacustrine deposit. The other facies associations represent the marginal facies. The facies association B has been interpreted as a Gilbert-type delta system, showing gravel bodies and prodelta bodies, consisting of marly clays, alternating with sands and gravelly mud strata. The facies association C corresponds to the coastal environment, composed of interbedded muddy and sandy strata and clayey silts and lignites, interpreted as a coastal wetland. The facies association D is represented by the distal part of a muddy alluvial fan. The paleoenvironmental reconstruction has indicated that the Tiberino Basin hosted a narrow lake during Pliocene times, whose size, shape, and depth were controlled by the tectonic setting. Beck [24] has highlighted that the Late Quaternary sedimentary fill of several lakes, located in the northwestern Alps, may represent a paleoseismological sedimentary archive. These peculiar strata have been controlled by mass failures or subaqueous slope deposits (delta foresets), evolving into hyperpicnal currents, and by in situ liquefaction and flowage, more than by micro-fracturing. The paleoseismic interpretation has been extrapolated up to 16 ky B.P., reconstructing the time series and identifying from a textural point of view several kinds of slope failure deposits. This has allowed to obtain the temporal series, which are compatible with the historical seismicity due to the observed recurrence interval.
\nThe Lake Bafa is a saline-brackish wetland ecosystem, having an international importance, which is located at the southeastern part of Büyük Menderes River Delta [25]. It is bounded by the Beşparmak Mountains to the south and to the east and by the alluvial plains of Büyük Menderes Delta to the north and to the west [25]. The lake’s surface area is 6708 hectares for 25 m depth, while the average water level is only 5 m [25]. The main water source is represented by the Büyük Menderes River, but some small streams have also contributed to the water input in the lake. The Lake Bafa has been formed as the result of delta progradation of the Büyük Menderes River. The sediments of the river have filled the marine embayment (Latimian Gulf). During the last millennia, the Latimian Gulf has been transformed into a deltaic and alluvial plain.
\nThe beaches and the barrier islands are long and narrow sand accumulations, occurring within the deltas, along the depositional strike from deltas or in an oceanic or lacustrine context, without any relationship with the deltas. Both the depositional systems are aligned parallel to the shoreline. The beaches are attached to the land, while the barrier islands are separated from the land by a shallow lagoon and are often dissected by tidal inlets. The formation of the beaches and of the barrier island systems includes a steady supply of sands to the shoreline (river input, longshore drift) and a hydrodynamic setting characterized by low and moderate wave energy but a limited tidal range. The beaches and the barrier islands have been constructed by the wave processes, which have been intensively studied through direct observation, experimentation, and theoretical procedures. Regarding the wave processes controlling the beaches, the first process to be discussed is the wave transformation, the second one is represented by the wave-induced nearshore currents, and the third one consists of the temporal variations in the wave regime. The major storm events have the role to control the landward retreatment or the local breaching of the eolian dune ridge. The beach includes a variety of sub-environments, including the eolian sand dunes, the backshore-foreshore, and the shoreface. In particular, the eolian sand dunes form complex ridges, capping the beach face above the mean tide level and resulting from wind reworking of sands emplaced in the upper beach by the storm waves, attaining a height of several meters. The backshore represents the supratidal part of the beach, which is flooded during the storm events, whereas the foreshore represents the intertidal area. The shoreface is the subtidal part of the beach, starting at the mean low tide level and terminating at the fair-weather wave base.
\nIn the coastal protection, the root systems of the mangrove forests trap sediments flowing down rivers and towards the land. This allows to stabilize the coastline and prevents the erosion operated from waves and storms. In the areas where the mangroves have been cleared, the coastal damage from hurricanes and typhoons is stronger. The role of mangroves in the coastal sedimentation has been deeply studied [26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43]. Alongi [26] has studied the carbon sequestration in the mangrove forests. The mangrove forests are highly productive, with the carbon production rates which are equivalent to the tropical humid forests. The mangroves host more carbon below the ground and have higher carbon mass ratios than the terrestrial trees. The most of the mangrove carbon is stored as large pools in the soil and dead roots. Moreover, the mangroves account for only approximately 1% of carbon sequestration by the world’s forests, but as coastal habitats they account for 14% of carbon sequestration by the global ocean. Banerjee et al. [27] have studied four sediment cores from selected locations of the Sundarbans mangroves and Hooghly estuary (northeastern coast of India) to reconstruct the 210Pb geochronology and to individuate the trace metal distribution in the sediments. The mangroves of India account for about 5% of the world’s mangrove vegetation and are spread over an area of about 6740 km2. The region of Sundarbans hosts the 10% of the mangrove forests in the world and a half of the total area under mangroves in India. The Sundarbans mangroves and the Hooghly estuary have received a considerable pollution load from anthropogenic sources such as the industrial, the domestic, and the shipping activities in recent times, suggesting a high concentration of metals in the top few layers. The obtained results have suggested that the variation in trace metal content with depth or between mangrove and estuarine systems derives from the metal input due to the anthropogenic activities rather than to the diagenetic processes. Blasco et al. [28] have examined the mangroves as indicators of coastal changes, studying in which way these ecosystems have been used as indicators of coastal changes or sea level rises. These ecosystems are specialized, and any minor variation of their hydrological and tidal regime controls a noticeable mortality. The mangroves are highly sensitive to the inundation regime. If the tectonic, sedimentologic, and hydrological events have been modified, these species tend to readjust to new environmental conditions, or alternatively, they tend to succumb to unsuitable environmental conditions. Perhaps, the use of the remote sensing data for the mangrove ecosystem represents a good tool in the coastal monitoring. In this book, the role of mangroves in the coastal and estuarine sedimentary accretion of southeastern Asia has been discussed. In fact, the mangroves provide also characteristic mechanisms in order to trap the sediments and to accelerate the land-building processes in the tide-dominated coastal and estuarine environments.
\nThis topic examines different studies on the sedimentary processes, including:
The geologic characteristics and the production response of the N5.2 reservoir, located offshore the Niger Delta and evaluating the geological elements, mainly the sedimentary facies and the structural lineaments, which have controlled the decline in the reservoir production
The example of the Lafe Bafa as an excellent geo-archive located in the Mediterranean sea, studied through lithostratigraphy, chronostratigraphy, and geochemical data, providing evidence for a continuous accumulation during the last 4.5 ky
The sedimentary processes in the riparian zone of the Ruxi Tributary Channel (Three Gorges Reservoir, China) applying a composite fingerprinting technique to apportion the sediment sources for the riparian zone with different elevations and studying the sedimentary input from this channel as a main source of pollution for the riparian environment
The long-term changes in the beach environments along the Kaike coast (Japan), reproduced using a contour-line change model which has taken into account the grain size of the beach sediments and evaluating the long-shore transport of sands through bathymetric data analysis
The role of the mangroves in the coastal and estuarine sedimentary processes in southeastern Asia, highlighting the sediment accretion between the different types of roots, the spatial variability of the sediment accretion, and the influence of the seasonal change impacts on the sediment accretion
The relationships of the sedimentary processes with the sea level changes and the subsidence have also been examined.
\nThe PID (Proportional Integral Differential) algorithm is the most popular feedback controller used within the process industries. It has been successfully used for over 50 years. It is a robust easily understood algorithm that can provide excellent control performance despite the varied dynamic characteristics of process plant. It is designed to generate an output that causes some corrective effort to be applied to a process so as to drive a measurable process variable towards a desired value, known as the set point. The concept is based (as shown in Figure 1) on the re-input of the system own output according to certain laws (hence the name “feedback”). It is desired for the system output to follow the set point. All feedback controllers determine their output by observing the difference, called error, between the set point and the actual process variable measurement. The PID looks at (a) the current value of the error, (b) the integral of the error over a recent time interval, and (c) the current derivative of the error signal to determine not only how much of a correction to apply, but for how long. Each of those three quantities are multiplied by a (tuning constant) and added together. Thus the PID output is a weighted sum. Depending on the application one may want a faster convergence speed or a lower overshoot. By adjusting the weighting constants, Kp, Ki, and Kd, the PID is set to give the most desired performance.
Typical closed loop control system.
As a result of enormous development in microcomputer technology, analog controllers have been replaced by digital controllers either in small or large industry. It is now a common practice to implement PID controllers in its digital version, which means that they operate in discrete time domain and deal with analog signals quantized in a limited number of levels. The trend toward digital rather than analog control is mainly due to: (1) versatility where programs can be easily modified or completely changed, (2) sophistication where advanced control laws could be implemented, (3) cost effectiveness where microcontrollers are available at very low costs compared to PLCs, industrial computers, RTUs or DCS. A typical digital feedback control system is shown in Figure 2. In digital feedback systems, the controller input and output are digital (sampled) rather than continuous signals. Thus, the continuous signal from the measurement device (sensor/transmitter) is sampled and converted periodically to a digital signal by an analog-to-digital converter (ADC). A digital control algorithm is then used to calculate the controller output as a digital signal. Because most final control elements are analog devices, the digital output signal is usually converted to a corresponding analog signal by a digital-to-analog converter (DAC).
Digital closed loop based on a microcontroller.
In feedback control, the objective is to reduce the error signal to zero where
where
The three-term PID controller.
where
A straightforward way of deriving a digital version of the parallel form of the PID controller is to replace the integral and derivative terms by finite difference approximations,
where
There are two alternative forms of the digital PID control equation, the position form and the velocity form. Substituting Eqs. (3) and (4) into (2) gives the
where
In the
Note that the summation still begins at
In this study, velocity form is chosen because of the following advantages:
It does not need initialization. The position form requires the initial value of the controller output
It is protected against integral windup. The integral mode of a controller causes its output to continue changing as long as there is a nonzero error. Often the errors cannot be eliminated quickly enough and given enough time they produce larger and larger values for the integral term, which in turn keeps increasing the control action until it is “saturated” (e.g., the valve completely opens or closes). This condition is called
It protects the process against computer failure. With the velocity algorithm one can send out a signal which is used to drive an integrating amplifier or a stepper motor. These devices will retain the last calculated position of the control valve (or other final control element) in case the computer fails, thus avoiding total loss of control of the process.
As mentioned earlier, the implementation is based on a Microchip PIC18F452 microcontroller, where the controller plays the role of the brain of the control system [5]. The right choice of the microcontroller is essential, as it will be the core of the final design. The PIC18F452 from Microchip has been chosen for the following advantages:
Speed: with its maximum internal clock rate of 20 MHz and its 16-bit-wide instruction bus, the CPU can execute most of its instructions at a single machine cycle of four clocks which is equivalent to a 0.2 μs.
Math support: unlike classical microprocessors, the controller in hand has got a hardware multiplier and divider for multiple-bytes, fixed-point numbers and for floating-point numbers so multiplication is carried out in a single instruction.
Flexible timer resources: four independent timers modules support timing measurements and output interval control with a timing resolution as fine as 0.1 μs. Those timers could be used to produce up to three pulse width modulations which could be used for electrical motor control.
Free software tools: Microchip’s Development Package MPLAB® (consisting of assembler, simulator, and user interface) as well as all manuals and application notes are available at no cost from their Web site (www.microchip.com).
Development tool versatility: it supports in-circuit debugger which permits the loading and execution of a user program as well as the use of breakpoints, memory/ register modification, and single stepping.
Build-in ADCs: it has analogue-to-digital converters with 10 bits resolution.
Built-in serial peripheral interface: it has a variety of serial bus interfaces like USART, I2C & SPI.
C programmable: it could be programmed using C language with the use of a variety of built in C libraries developed by microchip.
The PIC18F452 microcontroller is a 40 or 44-pin depending on the package, where in the 40 pins configuration, a dual inline package is used; whereas in the 44 pins configuration, either thin quad flat package or dual flat no leads package is used. Its design is based on Harvard technology where the program and data have different buses. This type of microcontrollers is very cheap, small in size, and could be customized. It could be easily programmed on-line using either assembly language, BASIC or C language. In fact, it is ideal for small application such as the one in hand. The controller has a 24 kbytes of flash memory and 2048 bytes of SDRAM. It also has a 8 × 10 bits analog to digital channels. It also has 5 bidirectional digital ports with 33 inputs/outputs, configured as follows: 3 × 8 digital I/O ports (PORTB, PORTC and PORTD), one six digital I/O port (PORTA) and one three digital I/O port (PORTE). Unfortunately, one of the drawbacks of microcontrollers, it is very seldom to find one with a digital to analog converter. Luckily, they are few manufacturers around including microchip, which make serial DACs which could be programmed through Serial Port Interface (SPI) using only three wires. The PIC18F452 has four timer/counters which could be programmed either as 8 or 16 bit timers/counters. It also has two ports which could be configured either as capture, compare or pulse width modulation (PWM). It has two serial peripheral interfaces: (SPI) and an inter-integrated circuit (I2C). An asynchronous port (USART) is also provided. For the microcontroller to output analogue data, an MCP4921 device is used. The device is a 12-bit buffered single voltage output Digital-to-Analog Converter (DAC). The device operates from a single 2.7 V to 5.5 V supply with an SPI compatible Serial Peripheral Interface. The user can configure the full-scale range of the device to be VREF or 2*VREF by setting the gain selection option bit (gain of 1 of 2). The user can shut down the device by setting the Configuration Register bit. In Shutdown mode, most of the internal circuits are turned off for power savings, and the output amplifier is configured to present a known high resistance output load (500 kΩ, typical). The device includes double-buffered registers, allowing synchronous updates of the DAC output using the LDAC pin. The device also incorporates a Power-on Reset (POR) circuit to ensure reliable powerup. The device utilizes a resistive string architecture, with its inherent advantages of low Differential Non-Linearity (DNL) error and fast settling time. The device is specified over the extended temperature range (+125°C). It provides high accuracy and low noise performance for consumer and industrial applications where calibration or compensation of signals (such as temperature, pressure and humidity) is required. The MCP4921 device is available in the PDIP, SOIC, MSOP and DFN packages. Figure 4 shows the chip pin configuration. The MCP4921 device is designed to interface directly with the Serial Peripheral Interface (SPI) port, which is available on the PIC18F452 microcontroller and supports Mode 0,0 and Mode 1,1. Commands and data are sent to the device via the SDI pin, with data being clocked-in on the rising edge of SCK. The communication is unidirectional; this means the data cannot be read out of the MCP4921. The CS (chip select active low) pin must be held low for the duration of a write command. The write command consists of 16 bits and is used to configure the DAC’s control and data latches. Register shown in Figure 5, details the write command which is loaded into the input register that is used to configure and load the DAC register [6].
MCP4921 pin configuration.
Write command register for MCP4921 (12-bit DAC).
The write command is initiated by driving the CS pin low, followed by clocking the four Configuration bits and the 12 data bits into the SDI pin on the rising edge of SCK. The CS pin is then raised, causing the data to be latched into the DAC’s input register. The MCP4921 utilizes a double-buffered latch structure to allow the analog output to be synchronized with the LDAC pin, if desired. By bringing the LDAC pin down to a low state, the content stored in the DAC’s input register is transferred into the DAC’s output register (VOUT), and VOUT is updated. The write to the MCP4921 device is 16-bit words. Any clocks past the 16th clock will be ignored. The Most Significant 4 bits are Configuration bits. The remaining 12 bits are data bits. No data can be transferred into the device with CS high. This transfer will only occur if 16 clocks have been transferred into the device. If the rising edge of CS occurs prior to that, shifting of data into the input register will be aborted. The most four significant bits are defined as follows:
bit 15 0 = Write to DAC register
1 = Ignore this command
bit 14 BUF: VREF Input Buffer Control bit
1 = Buffered
0 = Unbuffered
bit 13
1 = 1x (VOUT = VREF * D/4096)
0 = 2x (VOUT = 2 * VREF * D/4096)
bit 12
1= Active mode operation. VOUT is available.
0 = Shutdown the device. Analog output is not available.
VOUT pin is connected to 500 kΩ (typical).
This module is designed to display the value of the temperature detected by the temperature sensor and to guide the user in changing the parameters of the controller. The LCD is a 16 × 2 alphanumeric display with the built-in Hitachi 44780 controller and LED backlighting. It works with an 8-bit data bus, which means it will require a total of 11 data lines. Three control lines (connected to port E) plus the 8 lines for the data bus (connected to port D) [7].
The system is design around a stand-alone PIC18F452 controller, where the measured variable (MV) is read through channel0 (pin 2). The MV is subtracted from the set point automatically by the controller. The error is treated by the PIC PID and produces a digital control variable. This control variable is outputted through PIC serial data output pin (SDO pin 24) together with serial clock pin (SCK pin 18) to synchronize the conversion process. For the conversion to take place, the serial DAC chip select (CS) has to be pulled low. The CS is connected to pin RC0. The positive reference voltage is connected to +5 V (pin 6) and the negative reference voltage (pin 7) is tied to zero volt. The analog output is read through pin8 (Vout). This voltage is small to drive an electric motor. This voltage is pulled up to +12 V through the non-inverting operational amplifier (LM358). The Darlington transistor 2SD1409 is used to bust the current. The motor is connected to the emitter follower so that the driving current is sufficient enough to drive the motor. Needless to say that the diode 1N4148 is used to protect the Darlington transistor against any spike due to the change of current. Figure 6 shows the schematic of the system. The LCD is used to display the measured temperature. To manipulate the setting of different parameters, six push buttons are used as follows:
System schematic circuit showing all the connection to the microcontroller, as well as the liquid crystal display and the final control element.
Six push buttons were used in the project to allow the user to change the setting and the controller parameters. Their functions are as follows:
Reset: To reset the microcontroller.
Stop: interrupt the program to allow the user to change the controller settings
Run: To run the program
Mode: To allow the user to change between setting modes.
Increment: To increment the controller variables by 1 or 0.1.
Decrement: To decrement the controller variables by 1 or 0.1.
These switches are connected to PIC PORTB to allow the user to use the internal build-in pull up resistors to prevent floating instead of using external pull-down resistors. The reset has got a separate button connected to MCLR pin. A buzzer is used as an alarm to indicate that the temperature is more than what the user specifies. Three LEDs were used to show the user the status of the microcontroller program. The three colors green, yellow, and orange were used as follows:
Green: means that the PID controller is working properly.
Yellow: means that the program is interrupted by (STOP) push button.
Red: means that the alarm is triggered.
To implement the control program, three major routines are used; the main routine along with the timer and external interrupts. The program starts with the main routine which contains all the configurations of the external pins whether outputs or inputs. It also contains the configurations of timer and external interrupts, so when one of these interrupts is triggered, the microcontroller will stop its current execution and perform another action. The trigger will be caused by either an overflow in timer register or a change on an external pin (RB0/INT0).
Because the time is a crucial element in digital control, the PID algorithm is controlled through a timer interrupt. This choice allows the user the ability to calculate the sampling time accurately. On the other hand, an external interrupt (INT0) is used to interrupt the program in order to allow the user a chance to modify the controller parameters. In the following we discuss in some details about the functions of each routine.
This routine, as mentioned earlier, is dedicated to configure the direction of external pins as well as interrupt sources. It also allows the user to choose the measured variable (temperature, flow, level or others). The flow chart of this routine is shown in Figure 7.
Main routine.
First PORTA (pin RA0) is configured as an analog input channel0 and PORTB as input digital port which is connected to the push button switches; while all other pins are configured as outputs.
The configuration of the LCD was performed by separate software from Microchip called Application Maestro [8]. With the aid of this software, a configuration code was produced after modifying the module parameters. It was then incorporated into the project. Once incorporated, the LCD is configured and ready to work. One feature of using Application Maestro is its ability to use the prewritten code that this software provides to initialize or to write to the LCD.
Timer0 can operate as a timer or as a counter. In Timer mode, the Timer0 module will increment with every instruction cycle (without prescaler). It is configured by setting a special function register called T0CON (timer0 control byte). This register is a readable and writable register that controls all the aspects of Timer0, including the prescale selection. In the design in hand, T0CON register is set to 0x85 (0b10000101) as shown below [9, 10].
This value will configure the timer0 as follows:
● | TMR0ON | = 1 | : Timer0 is enabled | ||
● | T08BIT | = 0 | : Timer0 is configured as a 16-bit timer | ||
● | T0CS | = 0 | : Internal instruction cycle clock | ||
● | T0SE | = 0 | : This bit is used only with external clock | ||
● | PSA | = 0 | : Timer0 prescaler is assigned | ||
● | T0PS2 | = 1 | : Bit2: T0PS2 =1: | } | 1:64 prescaler value |
● | T0PS1 | = 0 | : Bit1: T0PS1 =0: | ||
● | T0PS0 | = 1 | : Bit0: T0PS0 =1: |
There are ten registers which are used to control internal and external interrupt operations to accommodate a variety of interrupts [11]. In the project in hand, only two interrupts are required INT0 and timer0 interrupt. To do so, only three control registers are required. These registers are INTCON, INTCON2, and RCON. INTCON register contains various enable bits as well as several interrupt flags. RCON is the Reset Control register which contains flag bits that allow differentiation between the sources RESET. Timer0 interrupt is enabled by setting TMR0IE bit (<5>) while external interrupt is enabled by setting INT0IE (INTCON<4>). Note that the interrupt flags are reset before enabling the interrupt in order to avoid unwanted interruptions.
To start the interrupt, the global interrupt bit GIE/GIEH (INTCON<7>) must be set. If set, it enables all unmasked interrupts, so if more than one interrupt source is used (as in our case) the Interrupt Priority Enable bit IPEN (RCON<7>) must be set and the interrupt sources should be specified either as high or low priority interrupt. The interrupt priority bit TMR0IP (INTCON2<2>) is used to specify the interrupt priority for Timer0. This bit is reset so timer0 interrupt is set to low priority. On the other hand, no need to specify the priority of the external interrupt (INT0), because it is already set to high priority by default.
After configuring the interrupts, the program will enter an infinite loop until one of the interrupt sources is triggered.
The main purpose of this routine is to calculate the controller output and send it to the DAC serially through the synchronous SPI module [12]. Figure 8 shows the routine function.
Timer interrupt routine.
Because of the importance of time in calculating the timed controller output, timer0 is used as an accurate hardware timer. The source clock of the timer is the crystal oscillator which is fed to the clock pin of Timer0 internally. The clock used is a 20 MHz derived from a stable crystal oscillator. This frequency is automatically divided by 4 because the controller machine cycle is 4 clocks to give a 5 MHz which is fed to the timer. The timer is exactly clocked every 0.2 μs and takes 13107.2 μs (16-bit mode) to count from zero to zero again. However, by loading the timer with a suitable value, a smaller time interval could be obtained. For example, by loading the timer with the value 4095 (0xFFF), the overflow would occur after 12288.2 μs. Alternatively, the time period can be extended by using a prescaler as was done in the main routine. If a divide by 64 prescaler is selected, timer0 only overflows after 838.848 ms. This is obtained as follows:
This time period is less than one second, while a one second sampling time is required for the design in hand. To obtain a one second sampling time, the timer should count 78,125 pulses.
Because timer0 register is only 16 bit wide, it is only limited to count up to 65,535 pulses. The interruption is trigged several times to obtain one second timing, after which the controller computes the control action and sends it to the DAC. By using MPLAP simulator, it was found that 5362 cycles are required to calculate the controller output and send it to the DAC besides 51 extra cycles needed to reload the timer with time constant. If the interruption is required to repeat itself five times before calculating the controller output, one needs 5362 + 51 × 5 = 5617 cycles (1.1234 ms). Thus, in order to get exactly one second sampling time, the timer register (TMR0) has to be reloaded with a value that interrupts the program every 998.8766 ms (1 s–1.1234 ms). The following shows how this value is obtained:
By using a timer with 64 prescaler:
When we repeat the interrupt for 5 times:
But because the timer counts in ascending order (from 0x0000 to 0xFFFF):
However, the timer register accepts only integer numbers, thus the final value that should be added to the timer register is 49918. Because we omitted the numbers after the decimal point, our error will be ± 1 count which is equal to 64 cycles. Therefore, our error in calculating the sampling time will be:
This calculation is for getting 1 s sampling time. To expand the calculation in order to enable the user to change the sampling time, one defines two integer variables (repeat and cycle). The first variable repeat is to determine how many times we need to repeat the interrupt, while the second one cycle is the final value that should be added to the timer register. The following pseudo code shows the general formula used to reload the timer register.
The ADC module normally operates at 10-bits resolution, giving output digital values 0–1024 [13]. It needs a reference voltage to set the maximum and minimum values for the input conversion. This reference can be provided internally as Vdd and Vss (supply values) or externally through Vref+ and Vref− pins. To configure this module, OpenADC function from Microchip C library is used. This function performs a bitwise AND operation (“&”) between its arguments which are defined in the file adc.h. The parameters of this function along with their meaning of each argument are discussed below [1]
ADC_FOSC_32: FOSC/32.
A clock divider to allow the minimum specified conversion time (about 20 μs). A 32 prescaler was chosen because the clock source is 20 MHz
ADC_RIGHT_JUST: Right justified.
Because the ADRES register pair (where the converted values are loaded) is 16-bit wide. But the ADC is only 10bit wide. The ADC module could either be configured as right or left justified. In this project, right justified is chosen as shown in Figure 9. This sets the 6 most significant bits of register ADRES to zeros.
ADC_8ANA_0REF: VREF+ = VDD, VREF− = VSS
The supply values are chosen as the voltage references to the ADC.
ADC_CH0: Channel0 (AN0) is selected
ADC_INT_OFF: Interrupts of ADC interrupts are disabled.
Once the A/D conversion is completed, the result is stored in an integer variable called result. After reading the analog value by the ADC module, the result will be compared with the variable alarm-trigger which was previously specified. If the result is greater than this value, the microcontroller triggers the buzzer and lights the red LED.
Choosing right justified for data input.
Due to the limitation in the microcontroller’s memory, the PID equation is divided into three terms (term_1, term_2, and term_3) and after calculating each term separately, they are added together along with the previous output to give the controller output which will be sent to the DAC. The following code shows how to calculate the controller output
To send the control variable to the final control element, the serial DAC, which is interfaced to the Serial Peripheral Interface (SPI) port, is used. The SPI is initiated using Microchip C library called OpenSPI. This function also performs a bitwise AND operation between its arguments which are defined in the file SPI.h according to the following formula.
SPI_FOSC_16: Master mode and the clock = FOSC/16
MODE_00: Mode 0,0 (change takes place on the rising edge)
SMPEND: Input data sample at end of data out
After configuring the module, it is time to write a command to the DAC in order to convert it into analog signal. The write command is initiated by driving the CS pin low, followed by clocking the four configuration bits and the 12 data bits into the SDI pin on the rising edge of SCK. The CS pin is then raised, causing the data to be latched into the DAC’s input registers and when the LDAC pin is pulled down through RC1, the values held in the DAC’s input registers are transferred into the DAC’s output registers to provide the analog signal. It is important to mention here that we wrote the write command in two steps (as shown in the following code) because the SPI module send only 8 bit at a time.
To write characters to the LCD, required prewritten functions are provided by Application Maestro. Some of These functions are listed in following table:
It is used to initialize the LCD module according to the Application Maestro options | |
It sends the clocking signal and data to be displayed to the LCD | |
Points to the first address location of line one of the LCD | |
Points to the first address location of line two of the LCD | |
Clears the DDRAM content of the LCD and points to the 00 address location | |
Displays String in Program memory | |
Displays String in Data memory | |
It sends clocking signal and instructions to the LCD |
For numbers to be displayed, they are first converted into strings (characters) before being sent to the LCD, since the latter only accepts strings. To do so a C function called sprintf is called upon. This function saves the number in an array after converting it into string. The subroutine to do so is shown below [4]:
The main function of this routine is to allow the user to change the controller parameters. The routine is initiated by pressing the push button (STOP) which is connected to the external interrupt pin (RB0/INT0). Once initiated, the user is able to change all the parameters of the controller (KC, τI, τD, sampling time, alarm trigger and sensitivity) by using three push buttons (MODE, INCREMENT and DECREMENT [11].
To determine which action the microcontroller should take if any push button is pressed, we defined two integer variables (present_button and present_mode) to be used as statuses. That is, each bit of them has specific meaning as described below:
present_button
Np | ____ | ____ | ____ | ____ | ____ | ____ | ____ | ____ | ____ | ____ | ____ | ____ | dec | inc | Mod |
bit15 | bit0 |
● | |
● | Unimplemented |
● | |
● | |
● |
present_mode
____ | Srt | Spt | KC | TI | TD | Stm | Sen | Alm | Tun | Dp | Tp | Kp | ____ | ____ | ____ |
bit15 | bit0 |
● | Unimplemented |
● | |
● | |
● | |
● | |
● | |
● | |
● | |
● | |
● | |
● | |
● | |
● | |
● | Unimplemented |
Initially, before pressing any push button, present_button variable is loaded with 0x8000 (no push button pressed), and present_mode with 0x2000 (starting mode).Then if any push button is pressed, the corresponding bit of that push button will be set, giving a specific value of present_button which indicates the push button that was pressed by the user. So by performing a bitwise OR operation between the two variables (present_button and present_mode) we will come up with a number indicates the push button pressed and the present mode and based on that number we can decide the proper action to be taken by the microcontroller. The following code shows how to perform the OR operation after checking which of the push buttons was pressed. Beside changing the controller variables, this routine has another feature, it gives the user preliminary values of the controller parameters after entering the process variables. The result is derived based on Cohen-Koon tuning method. However, this feature is impractical if the sampling time is big [14].
To test the system, a first order system given by the equation below was used. To run the control action, the system was converted into a difference equation given by Eq. (10).
The process transfer function is first order, thus the discrete transfer function obtained using Zero-Order Hold will be:
where:
If
Therefore the difference equation of the output is:
After getting the difference equation, the control scheme was tested and the output of Figure 10 was obtained with the parameters set to:
Controller response with Kc = 0.2, Ti = 4.0 and Td = 0.
Controller response with Kc = 0.1, Ti = 3.0 and Td = 0.2.
By referring to the previous graphs, it could be concluded that the response tracks the set point as expected. In addition, the increase in controller gain (
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From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. 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He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. 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His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},onlineFirstChapters:{paginationCount:21,paginationItems:[{id:"80761",title:"Extractions Methods and Biological Applications of Essential Oils",doi:"10.5772/intechopen.102955",signatures:"Sonu Kumar Mahawer, Himani, Sushila Arya, Ravendra Kumar and Om Prakash",slug:"extractions-methods-and-biological-applications-of-essential-oils",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"81545",title:"Physiochemical Properties of Essential Oils and Applications",doi:"10.5772/intechopen.104112",signatures:"Sunil Kumar Yadav",slug:"physiochemical-properties-of-essential-oils-and-applications",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"81067",title:"Encapsulation of Essential Oils and Their Use in Food Applications",doi:"10.5772/intechopen.103147",signatures:"Hamdy A. Shaaban and Amr Farouk",slug:"encapsulation-of-essential-oils-and-their-use-in-food-applications",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"80959",title:"Biological Application of Essential Oils and Essential Oils Components in Terms of Antioxidant Activity and Inhibition of Cholinesterase Enzymes",doi:"10.5772/intechopen.102874",signatures:"Mejra Bektašević and Olivera Politeo",slug:"biological-application-of-essential-oils-and-essential-oils-components-in-terms-of-antioxidant-activ",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"80859",title:"Antioxidant Effect and Medicinal Properties of Allspice Essential Oil",doi:"10.5772/intechopen.103001",signatures:"Yasvet Yareni Andrade Avila, Julián Cruz-Olivares and César Pérez-Alonso",slug:"antioxidant-effect-and-medicinal-properties-of-allspice-essential-oil",totalDownloads:34,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"80777",title:"Starch: A Veritable Natural Polymer for Economic Revolution",doi:"10.5772/intechopen.102941",signatures:"Obi P. 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