IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\n
IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
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Designed to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\n
After a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
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Our innovative Book Series format brings you:
\n\n
\n\t
Topic Focused Publications - Each topic showcases high impact subject areas
\n\t
Renowned Editorial Expertise - Series Editors, Topic Editors, and a team of international Board Members that permanently support each Book Series
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Fast Publishing - quick turnaround which is unique for book publishing
\n\t
The benefit of ISSN and ISBN for increased citation and indexing possibilities
\n
\n\n\n\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\n
IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
We invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
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Note: Edited in October 2021
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Dr. Muhammad earned a BSc in Mechanical Engi-neering and an MSc in Manufacturing System Engineering from Lehigh University, Pennsylvania, USA. He earned his PhD in Mechanical Engineering at UTP with research on “Reliability Model for Repairable Systems with Multi-State Degradation.” He is actively involved in research col-laboration and consultancy with industries, and he supervises graduate students studying reliability and maintenance. He has twelve years of experience working in various positions at one of the leading semiconductor companies, involving pro-cess and equipment engineering, product development and material quality. He is a chartered engineer and member of the Board of Engineers Malaysia (BEM), the Institute of Engineers, Malaysia (IEM), and the American Society of Mechanical Engineers (ASME). 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\r\n\tThe importance and significance of aquifers are growing day by day as the world's population is becoming large. Many areas of the developing countries are since dependent on aquifers for their water needs; it is important to look at them holistically, whether mapping their future potential or monitoring. New tools and methods are now available, dictating the proper, judicious, and best use of our water resources that are available in the aquifers beneath the ground surface. The scientific approach to the various aspects of aquifers, including their management, will be the principal topic of focus in this book. Through case studies and technical contributions from several experienced authors all over the globe, the topic of aquifers has been covered. Most of the relevant aquifer sub-areas of significance will be described in this open access book, if not all. Hence, this publication will be a valuable one for avid book readers, particularly academicians, scientists, field personnel, researchers, and students in different countries.
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He has also received a prestigious “Jal Seva” Award of IWWA for the year 2016-17, “Best lecture” Award in 2018-19, and Linga Raja Das Memorial Trophy 2019-20, IWWA.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"271093",title:"Dr.",name:"Abhay",middleName:null,surname:"Soni",slug:"abhay-soni",fullName:"Abhay Soni",profilePictureURL:"https://mts.intechopen.com/storage/users/271093/images/system/271093.jpg",biography:"Dr. A.K. Soni, Ph.D., graduated with a degree in Mining Engineering from Ravishankar University, Raipur, Chhattisgarh, in 1983. He completed his post-graduate studies at the Birla Institute of Technology and Science (BITS), Rajasthan, India, and obtained a Ph.D. in Environmental Science and Engineering from the Centre of Mining Environment, Indian School of Mines (ISM), Dhanbad, India, in 1998. \n\n\n\nDr. Soni is currently working as Chief Scientist at CSIR-Central Institute of Mining and Fuel Research (CSIR-CIMFR) at Nagpur Research Centre and engaged in research work on 'mine environment and allied areas.” His area of research interest is 'geo-hydrological problems related to mines.” He has more than 33 years of experience working in the Indian mining industry. As part of his research work, he has visited the United States and the United Kingdom and traveled widely across India. As a research scientist and technical administrator, he has more than 115 technical publications on mining and environmental topics to his credit. Dr. Soni has authored one book, Mining in the Himalayas: An Integrated Strategy. 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From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. 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\n
1. Introduction
\n
Lifetime monitoring systems are an effective way to perform condition base maintenance of gas turbine engines [1, 2, 3]; this allows a better use of the available lifetime and improvement of the engine’s reliability.
\n
Several approaches exist to predict the remaining lifetime, such as neural networks [4, 5, 6, 7], finite element analysis (FEA) [8, 9, 10], and statistical methods [11]; however, in order to significantly enhance the accuracy of the lifetime prediction, it is necessary to estimate the lifetime in real time (on-line prediction) using actual conditions [12, 13]. All of the previously cited approaches require a large amount of computing resources, making them not suitable for an on-line application; another limitation is that none of the cited approaches take into consideration the existing engine-to-engine differences and the performance deterioration.
\n
Oleynik proposes in a study [14] an approach to perform on-line lifetime prediction of engine component condition (Figure 1); he proposes to use simple models to estimate the temperature and stresses at critical points. A major advantage of this approach is the use of actual engine operating and atmospheric conditions as input data. The methodology has been proven by practical application in monitoring of some Ukrainian engines.
\n
Figure 1.
Scheme for on-line lifetime prediction.
\n
As shown in Figure 1, one of the blocks performs the thermal condition (TC) monitoring, while the second block, the stress condition (SC) monitoring.
\n
Inside the block of TC, it is necessary to set the thermal boundary conditions (gas temperature around the critical element and the heat transfer coefficient between the gas and metal), which are not measured parameters; the author [14] proposed a methodology to develop mathematical models based on the theory of similarity to estimate these boundary conditions.
\n
In this chapter a new approach to develop physics-based models to estimate the unmeasured parameters is proposed and analyzed. This new approach emphasizes the accuracy of the models regardless of the engine-to-engine differences, taking into consideration a healthy and faulty engine condition.
\n
With the help of the thermodynamic model of the engine chosen as test case, all the necessary data for model developing and validation is simulated; the simulation of the engine’s component degradation is widely used in gas turbine monitoring and diagnostics [15, 16].
\n
A comparison between the physics-based models and the reference method based on the theory of similarity proposed by [14] is conducted to validate the accuracy of the methods.
\n
Finally, the influence of the accuracy in the prediction of the thermal boundary conditions on the errors of the engine lifetime prediction is evaluated.
\n
\n
\n
2. Test case
\n
It is well-known that the thermomechanical stresses in gas turbine hot elements are very high, particularly in the turbine blade having a significant effect on the safety and economics of the fleet operation [17]. For this reason, a turbine blade with three cooling channels has been chosen as the test case; the blade is mounted in the first stage of the high-pressure turbine (HPT) of a two-spool free turbine engine.
\n
In Table 1 the seven measured gas path parameters of the engine chosen as test case are listed.
\n
\n
\n
\n\n
\n
Designation
\n
Gas path parameter
\n
\n\n\n
\n
\n\n\n\nG\nf\n\n\n\n
\n
Fuel consumption
\n
\n
\n
\n\n\n\nT\nC\n∗\n\n\n\n
\n
Compressor discharge temperature
\n
\n
\n
\n\n\n\np\nC\n∗\n\n\n\n
\n
Compressor discharge pressure
\n
\n
\n
\n\n\n\nT\nHPT\n∗\n\n\n\n
\n
HPT discharge temperature
\n
\n
\n
\n\n\n\np\nHPT\n∗\n\n\n\n
\n
HPT discharge pressure
\n
\n
\n
\n\n\n\nT\nLPT\n∗\n\n\n\n
\n
Low-pressure turbine (LPT) discharge temperature
\n
\n
\n
\n\n\n\nn\nHP\n\n\n\n
\n
Rotational speed of the high-pressure (HP) rotor
\n
\n\n
Table 1.
List of gas path measured parameters of the engine selected as test case.
\n
Experience has shown that it is sufficient to consider a two-dimensional analysis of the mid-span section of the blade in order to save computing time; however, the same methodological approach can be applied for a three-dimensional geometry.
\n
The finite element model of the mid-span turbine blade section was built with the help of FEA software. After setting all the necessary boundary conditions, the distribution of the temperature and stresses was obtained. The critical points with the smallest safety factor were found as well; as shown in Figure 2, the critical points correspond to the numbers 101, 102, 103, and 69.
\n
Figure 2.
Critical points at the turbine blade mid-span section.
\n
Three critical points are located at the leading edge of the blade and one critical point at the trailing edge. For an easier analysis, the four critical points are organized into two groups: group a (GA) contains the critical points 101, 102, and 103, and group b (GB) contains the critical point number 69.
\n
The thermodynamic model of the engine chosen as test case [18] is used to generate all the data for model developing and validation.
\n
\n
\n
3. Engine lifetime monitoring system
\n
A brief description of the lifetime monitoring system proposed by the author [14] is presented to have a better understanding. As shown in Figure 1, the block to perform the TC contains the sub-block named “thermal boundary conditions” (unmeasured parameters). The new approach for model developing proposed in this chapter focuses all the efforts in improving the accuracy in this sub-block, as improving the efficiency in the prediction of the thermal boundary conditions directly affects the accuracy of the whole monitoring system.
\n
In the following subsection, the simple mathematical models used to estimate the blade temperature and the thermal stress at the critical points are explained.
\n
\n
3.1 Turbine blade thermal and stress monitoring models
\n
In [19] an analysis of the models proposed by [14] to estimate the blade temperature and stress applied to the same turbine blade and critical points was conducted. As a result, it was concluded that the best model to calculate the blade temperature at the critical points is:
Here \n\n\nt\ncr\n\n\n is the blade temperature at the critical point, \n\n\nT\n\nS\n1\n\n∗\n\n\n is the cooling temperature, \n\n\nT\n\nS\n2\n\n∗\n\n\n is the heating temperature, \n\nΘ\n\n is a dimensionless parameter, and \n\n\nk\nα\n\n\n is the relation of the heat transfer coefficients at current and reference engine operating modes:
\n
\n\n\nk\nα\n\n=\n\n\nα\ni\n\n\nα\nref\n\n\n\nE2
\n
Here \n\n\nα\ni\n\n\n and \n\n\nα\nref\n\n\n are the heat transfer coefficients at actual and reference engine working operating modes, respectively.
\n
The model to estimate the thermal stress at critical points is:
Here \n\n\nσ\nt\n\n\n is the thermal stress at the critical point, \n\n\nS\n¯\n\n\n is a dimensionless parameter, and \n\nn\n\n is the rotational speed.
\n
The dimensionless parameters \n\nΘ\n\n in Eq. (1) and \n\n\nS\n¯\n\n\n in Eq. (3) are calculated as dependence of \n\n\nk\nα\n\n\n using a polynomial with gas path measured parameters as arguments.
\n
The parameters \n\n\nT\n\nS\n1\n\n∗\n\n\n, \n\n\nT\n\nS\n2\n\n∗\n\n\n, and \n\n\nk\nα\n\n\n are unmeasured parameters, which further will be referred as thermal boundary conditions; since this unmeasured parameters are the input data in Eqs. (1) and (3), it is necessary to develop mathematical models for their prediction. In the following section, the model developing methodology is explained.
\n
\n
\n
\n
4. Model developing methodology
\n
As mentioned in the introduction, a new approach for model developing is proposed. Since the models will be used in an on-line monitoring system, it is necessary to meet the following requirements:
The models must be developed on physics-based relations, such as thermodynamic and kinematic relations and others.
All models must use the gas path measured parameters as input data.
The structure of the models must be simple.
The measuring error of the gas path parameters, which are the input data of the models, must be taken into account.
The models must have high robustness to the influence of engine’s component deterioration.
\n\n
Taking into account the main requirements, the following general dependence for any unmeasured parameter is proposed:
Here \n\nz\n\n is the vector of unmeasured parameters to be predicted; \n\nY\n\n is the vector of gas path measured parameters; \n\nW\n\n is the vector of the intermediate unmeasured parameters which describe the thermodynamic properties of the fluid, such as efficiencies and pressure loss factors; and \n\n\nT\nH\n∗\n\n,\n\nP\nH\n∗\n\n\n are the ambient conditions.
\n
As shown in Eq. (4), such dependence is not possible to be used in an on-line monitoring system since it includes the vector \n\nW\n\n, which is an unmeasured parameter. In order to solve this inconvenience, it is proposed to estimate each unmeasured parameter \n\nw\n\n as a function A (internal model) using one of the available gas path measured parameters as argument \n\nw\n=\nA\n\nx\n\n\n, where \n\nx\n\n is a gas path measured parameter.
\n
Besides, all the parameters are corrected to standard atmosphere to take into account the influence of atmospheric conditions [20]. After rewriting Eq. (4), the general dependence for any unmeasured parameter is:
\nFigure 3 shows the algorithm to estimate the unmeasured parameters using the previously presented model developing methodology.
\n
Figure 3.
Algorithm to estimate the unmeasured parameters.
\n
\n
4.1 Model verification
\n
The best models are selected during the model verification process. The total mean square error (MSE) is the main criteria to select the best models; the MSE consists of two components, a truncation error and an instrumental error:
\n
\n\n\nσ\nTT\n\n=\n\nσ\nTR\n\n+\n\nσ\nINS\n\n\nE6
\n
Here \n\n\nσ\nTT\n\n\n is the total MSE, \n\n\nσ\nTR\n\n\n is the truncation error, and \n\n\nσ\nINS\n\n\n is the instrumental error.
Here \n\n\nz\n\nj\n\ni\n\nm\n\n\n\n is the value of the unmeasured parameter calculated by the developed models, \n\n\nz\n\nj\n\ni\n\n\n\n is the true value obtained from the engine thermodynamic model, and \n\n\nN\nj\n\n\n is the sample size; in other words, it is the number of engine operating points considered for analysis corresponding the engine health condition number j.
\n
The average truncation error in percentage for any engine health conditions is obtained by:
Here \n\nQ\n\n is the amount of gas path measured parameters, and \n\nK\n\n is the amount of internal models, which are part of the developed model to estimate the unmeasured parameter\n\nz\n\n.
\n
The average instrumental error in percentage is obtained by:
Here N is the sample size—the number of engine operating points corresponding to a healthy engine condition.
\n
\n
\n
4.1.3 Model robustness analysis
\n
Engine health conditions in real life are different from engine to engine; therefore, it is necessary to take into account these shifts from the ideal engine. For the model robustness analysis, the truncation error is calculated for several engine health conditions. In [21] the most common engine faulty conditions of a two-spool free turbine engine were analyzed; as a result, 10 faulty engine conditions were selected.
\n
In Table 2 the 11 engine conditions considered for analysis are listed. The deteriorated engine condition represents a 3% shift from engine health condition.
\n
\n
\n
\n
\n\n
\n
Designation
\n
Fault parameter
\n
Deteriorated condition
\n
\n\n\n
\n
C1
\n
—
\n
Healthy engine
\n
\n
\n
C2
\n
\n\n\n\nδη\nC\n\n\n\n
\n
Compressor efficiency decrease
\n
\n
\n
C3
\n
\n\n\nδ\n\nG\nC\n\n\n\n
\n
Compressor airflow decrease
\n
\n
\n
C4
\n
\n\n\n\nδη\nCC\n\n\n\n
\n
Combustion chamber (CC) efficiency decrease
\n
\n
\n
C5
\n
\n\n\n\nδσ\nCC\n\n\n\n
\n
Decrease in the CC total pressure
\n
\n
\n
C6
\n
\n\n\n\nδη\nHPT\n\n\n\n
\n
HPT efficiency decrease
\n
\n
\n
C7
\n
\n\n\nδ\n\nF\nNBHPT\n\n\n\n
\n
HPT nozzle box (NB) area increment
\n
\n
\n
C8
\n
\n\n\n\nδσ\n\nHPT\n−\nLPT\n\n\n\n\n
\n
Decrease in the total pressure between HPT and LPT duct
\n
\n
\n
C9
\n
\n\n\n\nδη\nLPT\n\n\n\n
\n
LPT efficiency decrease
\n
\n
\n
C10
\n
\n\n\nδ\n\nF\nNBLPT\n\n\n\n
\n
LPT NB area increment
\n
\n
\n
C11
\n
\n\n\nδ\n\nG\nST\n\n\n\n
\n
Increment of the air bleed for gas pumping needs
\n
\n\n
Table 2.
Engine healthy and faulty condition considered for analysis.
\n
\n
\n
\n
\n
5. Developing and verification of models for unmeasured parameters for the test case
\n
As shown in SubSection 3.1, it is necessary to calculate the input data for Eqs. (1) and (3). For our particular test case, the selected thermal boundary conditions are shown in Table 3.
\n
\n
\n
\n\n
\n
Cooling temperature
\n
\n\n\n\nT\n\nS\n1\n\n∗\n\n=\n\nT\nC\n∗\n\n\n\n
\n
\n
\n
Heating temperature
\n
\n\n\n\nT\n\nS\n2\n\n∗\n\n=\n\nT\nW\n∗\n\n\n\n
\n
\n
\n
Relation of heat transfer coefficients for hot gases
Here \n\n\nT\nC\n∗\n\n\n is the compressor discharge temperature, and \n\n\nT\nW\n∗\n\n\n is the gas temperature in relative motion in front of the first turbine stage.
\n
It is necessary to develop alternative models for each one of the selected thermal boundary conditions. Although the compressor discharge temperature is a measured gas path parameter for our test case (Table 1), it is of particular interest to analyze the effect of its inclusion or exclusion from the list of gas path measured parameters in the overall lifetime prediction.
\n
Since many alternative models were developed, only one example will be shown in order to save available text space; for more details consult [21].
\n
\n
5.1 Model developing
\n
Let us consider the gas temperature at the inlet of the turbine \n\n\nT\ng\n∗\n\n\n. As mentioned in Section 4, the models must be physics-based; therefore, we use the relation that describes the power balance between the high-pressure turbine and the high-pressure compressor [20] as the base equation for model developing:
\n
\n\n\nN\nT\n\n⋅\n\nη\nm\n\n=\n\nN\nC\n\n\nE11
\n
Here \n\n\nN\nT\n\n\n is the turbine power, \n\n\nη\nm\n\n\n is the mechanical efficiency, and \n\n\nN\nC\n\n\n is the compressor power.
Here \n\n\nG\ng\n\n\n and \n\n\nG\na\n\n\n are the gas and air flow consumptions accordingly, and \n\n\nC\n\np\n\ng\n\n\n\n and \n\n\nC\n\np\n\na\n\n\n\n are the specific heat values at constant pressure for gas and air accordingly.
\n
Solving Eq. (11) for \n\n\nT\ng\n∗\n\n\n, we obtain:
Let us remember that all the internal models will be calculated as a polynomial functions using one of the available gas path measured parameters as argument.
\n
Finally, after making the correction to standard atmospheric conditions of Eq. (14), we arrive at the following expression:
Here \n\n\nT\n0\n\n\n = 288.15 K is the value of standard atmospheric temperature.
\n
Several models can be developed for the same unmeasured parameter based on different source equations (alternative models). Figure 4 shows the general scheme for the developing of alternative models.
\n
Figure 4.
Scheme for the developing the alternative models.
\n
Using the scheme shown in Figure 4, a total of 31 models were developed for our test case (see reference [21]). A name is given to each developed model for easier identification, for example, the model shown in Eq. (16) is named MTG1. The names and arguments for each alternative developed model are shown in Figure 5.
\n
Figure 5.
Structure of the alternative models developed for our test case.
\n
\n
\n
5.2 Model verification
\n
Let us consider the model MTG1 shown in Eq. (16), which includes the internal model \n\n\nA\n\nTG\n1\n\ncor\n\n\n\nx\n\n\n. It is necessary to analyze which of the gas path measured parameters (Table 1) is best suited to be used as argument in the polynomial, as well as the degree of the polynomial that results in the most accurate prediction of \n\n\nT\ng\n∗\n\n\n.
\n
All of the necessary data for the analysis was obtained using the thermodynamic model of the engine selected as test case [18]. A total of 245 engine operating modes for a healthy engine condition were simulated; these operating modes describe the whole range of the engine operating conditions.
\n
The generated data was randomly divided into two sets. The first set of 123 operating points is used as reference. The second set of 122 operation modes is for model validation. Using the data from the reference set, the coefficients for the polynomial functions were obtained using the least square method.
\n
The polynomial degree was changed from 1 to 4 using each one of the gas path measured parameters (see Table 1) as argument in the polynomial.
\n
Once all the polynomial coefficients describing the internal model \n\n\nA\n\nTG\n1\n\ncor\n\n\n\nx\n\n\n were obtained, the value of \n\n\nT\ng\n∗\n\n\n was calculated. According to the scheme shown in Figure 3, it is necessary to perform an inverse conversion of Eq. (16) to calculate the value of \n\n\nT\ng\n∗\n\n\n as follows:
The total error (see Eq. (6)) was the main criteria to assess the accuracy of the developed models. A total of 11 engine conditions (Table 2) were considered for the model validation (model robustness analysis).
\n
\nFigure 6(a) depicts the total error in the prediction of \n\n\nT\ng\n∗\n\n\n using the model MTG1 with different gas path measured parameters as argument in the polynomial to describe the internal model \n\n\nA\n\nTG\n1\n\ncor\n\n\n\nx\n\n\n. From this figure it is clear that the lowest error is obtained when \n\n\nT\nHPT\n∗\n\n\n is set as argument.
\n
Figure 6.
Total error in the prediction of \n\n\nT\ng\n∗\n\n\n using model MTG1. (a) Using seven different measured parameters as argument; (b) detailed view for the best argument.
\n
\nFigure 6(b) shows that it is sufficient to use a third-degree polynomial as further increment does not reduce the total error in the prediction.
\n
From this analysis the polynomial degree and the gas path measured parameter to be used as argument in Eq. (17) are selected:
The selection of the argument in the i-internal models and the best polynomial degree for all the developed models was done using the same methodology. After the model verification of all the developed models, the best models were selected. Figure 7 shows the selected models to calculate the thermal boundary conditions for the test case.
\n
Figure 7.
Selected models to monitor the thermal boundary conditions of the test case.
\n
\n
\n
\n
6. Comparative analysis for the model accuracy
\n
Let us conduct a comparative analysis between two approaches for model developing: the first approach for model developing [14] uses the theory of similarity (reference model), and the second approach is proposed in this chapter and uses a physics-based methodology.
\n
\n
6.1 Thermal boundary condition prediction
\n
The thermal boundary conditions for our test case (see Table 3) were calculated using models developed with both methodologies.
\n
The total error was calculated according to Eq. (6), and the model robustness analysis took into account the 11 engine health conditions listed in Table 2. It is of particular interest to analyze the model robustness, since such analysis for the reference methodology does not exist.
\n
In Figure 8 the truncation errors for the thermal boundary condition prediction are presented.
\n
Figure 8.
Truncation error in the prediction of thermal boundary conditions for different engine health conditions. Blue color, physics-based models; red color, models developed on theory of similarity. (a) \n\n\nT\nW\n∗\n\n\n; (b) \n\n\nT\nC\n∗\n\n\n; (c) \n\n\nk\n\nα\n\ng\n\n\n\n; (d) \n\n\nk\n\nα\n\na\n\n\n\n.
\n
From Figure 8, it is clear that the models developed using the approach introduced in this chapter are more robust; it means that the models are less sensitive to the deviations from a healthy engine condition. This is a major advantage compared to the reference methodology based in the theory of similarity [14].
\n
\n
\n
6.2 Prediction of the thermal-stress condition and engine lifetime
\n
The thermal-stress engine condition was calculated using Eqs. (1) and (2). The prediction of the turbine blade lifetime is a very complex process, which involves different factors; however, a conservative lifetime prediction will be enough to assess the impact that a new model developing methodology has on the accuracy of the lifetime prediction. According to the author [22], a practical way to predict lifetime is the Larson-Miller relation:
Here PLM is the Larson-Muller parameter; C is a coefficient, which for the test case is equal to 20.
\n
As mentioned in Section 5, it is of particular interest to analyze what is the influence of the inclusion or exclusion of the compressor temperature \n\n\nT\nC\n∗\n\n\n as a gas path measured parameter in the accuracy of TC, SC, and lifetime prediction tr\n. Therefore, the thermal-stress condition and lifetime prediction are calculated for two cases. For the first case, the compressor temperature is not measured, and for the second case, the compressor temperature is measured.
\n
\n
6.2.1 Prediction of the thermal-stress condition and engine lifetime when the compressor temperature is not measured
\n
\nFigure 9 presents the total error in the prediction of TC, SC, and lifetime tr\n. From Figure 9(a) it is clear that the physics-based models give a better prediction of TC. Figure 9(c) shows that the improvement in the prediction of SC is not as significant, especially for the critical points GB. Figure 9(e) shows that the prediction of the lifetime tr\n is highly improved compared to the results obtained when the models based on the theory of similarity are used to calculate the thermal boundary conditions.
\n
Figure 9.
Total error in the prediction of TC, SC, and tr. Blue color, physics-based models; red color, models developed on the theory of similarity. (a, c, e) \n\n\nT\nC\n∗\n\n\n is an unmeasured parameter; (b, d, f) \n\n\nT\nC\n∗\n\n\n is a measured parameter.
\n
From this analysis, it is clear that the methodology used for developing the models of the unmeasured parameters has a great impact in the final accuracy of the lifetime tr\n prediction.
\n
\n
\n
6.2.2 Prediction of the thermal-stress condition and engine lifetime when the compressor temperature is measured
\n
We repeated the calculation, but this time the value of the compressor temperature is measured. Figure 9(b) shows that the total error in the prediction of TC for both groups is still better when using physics-based models.
\n
\nFigure 9(d) shows that the accuracy in the prediction of the SC is not significantly affected. From Figure 9(f) it is clear that the improvement in the prediction of TC has a significant impact in the prediction of the lifetime tr\n, for example, for the critical point GA when using physics-based models, an improvement in the prediction of TC from 0.58 to 0.44% leads to a better lifetime prediction from 45.95 to 27.96%.
\n
We can conclude that the accuracy in the prediction of the lifetime is highly improved when the temperature after the compressor is a measured parameter.
\n
\n
\n
\n
\n
7. Conclusions
\n
A new approach for model developing to estimate the unmeasured parameters in an engine lifetime monitoring system was introduced. This is an effort to increase the accuracy of the lifetime prediction.
\n
All the developed models have a very simple structure and are physics-based, making them ideal to be applied in an on-line lifetime monitoring system.
\n
A turbine blade mounted on the first stage of the high-pressure turbine of a two-spool free turbine power plant is the test case.
\n
Several alternative models were developed using different basic equations. Some of the models include in their structure an internal model, which characterizes the thermodynamic properties of the working fluid, such as efficiencies, pressure loss factors, and others. The internal models were defined by a polynomial function. The best measured parameter used as argument in the polynomial and the degree of the polynomial function were selected using the mean square error as criteria.
\n
All the necessary data for model developing and validation was generated with the engine thermodynamic model.
\n
The truncation and instrumental error are the main criteria to select the best models. Ten engine faulty conditions were considered for the robustness analysis of the models.
\n
A comparative analysis between two model developing methodologies was conducted: physics-based methodology (proposed in this chapter) and models developed on the theory of similarity (reference). The results show that the physics-based models are less sensitive to shifts from the engine healthy condition.
\n
It was found that the use of the proposed model developing methodology provides a better estimation of the thermal boundary conditions, which leads to a significantly better prediction of the lifetime.
\n
It was proven that the compressor temperature has a great impact in the lifetime prediction. If this parameter is not measured, then the accuracy of the lifetime prediction is significantly worse compared to the results obtained when the compressor temperature is measured.
\n
The obtained results show that it is possible to use the proposed model developing methodology in real applications; however, it is necessary to take into account a proper interpretation of the results obtained in this chapter. The reference data, which was used to determine the accuracy of the models, is simulated data; therefore, it is possible that the errors of the lifetime monitoring under real conditions will grow. To avoid such inconvenience, it is possible to replace the data generated with the help of the engine thermodynamic model with real data. This approach is valid, since the engine thermodynamic model is not part of the proposed model developing methodology. In order to obtain the necessary real data, it will be necessary to use additional instrumentation under engine test bed conditions.
\n
\n
Nomenclature
Subscripts
\na\n
air
\ncor\n
corrected parameter
\ncr\n
critical point
\nC\n
compressor
\nCC\n
combustion chamber
\nCH\n
channel
\nf\n
fuel
\ng\n
gas
\nH\n
atmospheric conditions
\nHP\n
high pressure
\nHPT\n
high-pressure turbine
\ni\n
i-engine mode
\nINS\n
instrumental error
\nj\n
j-engine health condition
\nLPT\n
low-pressure turbine
\nm\n
value calculated with the help of models, mechanical
\nNB\n
nozzle box
\nref\n
reference engine mode
\nST\n
gas pumping station
\nS1\n
cooling
\nS2\n
heating
\nt\n
thermal
\nT\n
turbine
\nTR\n
truncation error
\nTT\n
total mean square error
\nW\n
relative velocity
Designations
G
consumption
T
temperature
p
pressure
n
rotational speed, number of engine health conditions
t
blade temperature
k
coefficient, isentropic factor
\n\n\n\nS\n¯\n\n\n\n
dimensionless parameter
z
unmeasured parameter
Y
gas path measured parameters
W
unmeasured parameters describing thermodynamic properties of the working fluid
A
internal model
x
measured parameter, argument of polynomial
\n\n\n\np\n0\n\n\n\n
standard atmospheric pressure (101.3 KPa)
\n\n\n\nT\n0\n\n\n\n
standard atmospheric temperature (288.15 K)
y
measured parameter
N
sample size (number of engine operation modes), power
C
engine condition, coefficient
L
thermodynamic work
Cp\n
specific heat at constant pressure
A
coefficient
Re
Reynolds number
Kα\n
relation of heat transfer coefficient at current and at a reference operation mode
tr\n
lifetime
Greek symbols
*
stagnation parameter
\nα\n
heat transfer coefficient
\n\n\nΘ\n\n\n
dimensionless parameter
σ
stress, mean square error, total pressure conservation
\nη\n
efficiency
δ
shift from healthy engine condition
\nμ\n
dynamic viscosity
\n',keywords:"gas turbine, lifetime prediction, model developing, thermodynamic relations, unmeasured parameters",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/70287.pdf",chapterXML:"https://mts.intechopen.com/source/xml/70287.xml",downloadPdfUrl:"/chapter/pdf-download/70287",previewPdfUrl:"/chapter/pdf-preview/70287",totalDownloads:439,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:37,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"August 16th 2019",dateReviewed:"October 29th 2019",datePrePublished:"November 29th 2019",datePublished:"May 27th 2020",dateFinished:"November 29th 2019",readingETA:"0",abstract:"Monitoring systems to predict the remaining lifetime of gas turbine engines are a major field of investigation, in particular, the monitoring systems that allow an on-line prediction. This chapter introduces and analyzes a new approach to develop mathematical models to estimate unmeasured parameters in an engine lifetime monitoring system; these models in contrast to previously developed models allow an on-line monitoring of unmeasured parameters, which are necessary to perform an on-line lifetime prediction. The blade of a high-pressure turbine (HPT) of a two-spool free turbine power plant is the test case. Several candidate models are developed for each unmeasured parameter; the best models are selected by their accuracy and robustness using the instrumental and truncation error as criteria. Ten faulty engine conditions are considered to analyze the model robustness. Two methods for model developing are compared; the first method uses physics-based models (proposed in this chapter), and the second method develops the models using the similarity concept (reference methodology). The results of the comparison show that the physics-based models are more robust to engine faults and overall they deliver a significantly more accurate prediction of the engine lifetime.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/70287",risUrl:"/chapter/ris/70287",book:{id:"8884",slug:"modeling-of-turbomachines-for-control-and-diagnostic-applications"},signatures:"Cristhian Maravilla and Sergiy Yepifanov",authors:[{id:"310553",title:"Dr.",name:"Cristhian",middleName:"Herrera",surname:"Maravilla",fullName:"Cristhian Maravilla",slug:"cristhian-maravilla",email:"cris_mahe@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Test case",level:"1"},{id:"sec_3",title:"3. Engine lifetime monitoring system",level:"1"},{id:"sec_3_2",title:"3.1 Turbine blade thermal and stress monitoring models",level:"2"},{id:"sec_5",title:"4. Model developing methodology",level:"1"},{id:"sec_5_2",title:"4.1 Model verification",level:"2"},{id:"sec_5_3",title:"4.1.1 Truncation error",level:"3"},{id:"sec_6_3",title:"4.1.2 Instrumental error",level:"3"},{id:"sec_7_3",title:"Table 2.",level:"3"},{id:"sec_10",title:"5. Developing and verification of models for unmeasured parameters for the test case",level:"1"},{id:"sec_10_2",title:"5.1 Model developing",level:"2"},{id:"sec_11_2",title:"5.2 Model verification",level:"2"},{id:"sec_13",title:"6. Comparative analysis for the model accuracy",level:"1"},{id:"sec_13_2",title:"6.1 Thermal boundary condition prediction",level:"2"},{id:"sec_14_2",title:"6.2 Prediction of the thermal-stress condition and engine lifetime",level:"2"},{id:"sec_14_3",title:"6.2.1 Prediction of the thermal-stress condition and engine lifetime when the compressor temperature is not measured",level:"3"},{id:"sec_15_3",title:"6.2.2 Prediction of the thermal-stress condition and engine lifetime when the compressor temperature is measured",level:"3"},{id:"sec_18",title:"7. Conclusions",level:"1"},{id:"sec_21",title:"Nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'\nJin H, Lodwen P, Pistor R. Remaining life assessment of power turbine disks. In: Proceedings of ASME Turbo Expo 2008: Power for Land, Sea and Air. Berlin, Germany: GT2008-51010; 2008\n'},{id:"B2",body:'\nAlexander V. Gas turbine plant thermal performance degradation assessment. In: Proceedings of ASME Turbo Expo 2008: Power for Land, Sea and Air. Berlin, Germany: GT2008-50032; 2008\n'},{id:"B3",body:'\nPhillip D, David D. Remaining life assessment technology applied to steam turbines and hot gas expanders. In: Proceedings of ASME Turbo Expo 2011: Power for Land, Sea and Air. Vancouver, Canada: GT2011-45324; 2011\n'},{id:"B4",body:'\nParthasarathy G, Menon S, Richardson K. Neural network models for usage based remaining life computation. In: Proceedings of ASME Turbo Expo 2006: Power for Land, Sea and Air. Barcelona, Spain: GT2006-91099; 2006\n'},{id:"B5",body:'\nYoon J, Kim T, Lee J. Simulation of performance deterioration of a microturbine and application of neural network to its performance diagnosis. In: Proceedings of ASME Turbo Expo 2008: Power for Land, Sea and Air. Berlin, Germany: GT2008-51494; 2008\n'},{id:"B6",body:'\nFast M, Assadi M, De S. Condition based maintenance of gas turbines using simulation data and artificial neural networks: A demonstration of feasibility. In: Proceedings of ASME Turbo Expo 2008: Power for Land, Sea and Air. Berlin, Germany: GT2008-50768; 2008\n'},{id:"B7",body:'\nPalme T, Breuhaus P, Assadi M. Early warning of gas turbine failure by nonlinear feature extraction using an auto-associative neural network approach. In: Proceedings of ASME Turbo Expo 2011: Power for Land, Sea and Air. Vancouver, Canada: GT2011-45991; 2011\n'},{id:"B8",body:'\nBlumenthal R, Hutchinson B, Zori L. Investigation of transient CFD methods applied to a transonic compressor stage. In: Proceedings of ASME Turbo Expo 2011: Power for Land, Sea and Air. Vancouver, Canada: GT2011-46635; 2011\n'},{id:"B9",body:'\nWeiss J, Subramanian V, Hall K. Simulation of unsteady turbomachinery flows using an implicitly coupled nonlinear harmonic balance method. In: Proceedings of ASME Turbo Expo 2011: Power for Land, Sea and Air. Vancouver, Canada: GT2011-46367; 2011\n'},{id:"B10",body:'\nJeromin A, Eichler C, Noll B. Full 3D conjugate heat transfer simulation and heat transfer coefficient prediction for the effusion-cooled warm of a gas turbine combustor. In: Proceedings of ASME Turbo Expo 2008: Power for Land, Sea and Air. Berlin, Germany: GT2008-50422; 2008\n'},{id:"B11",body:'\nGiuseppe F, Carlevaro F. Gas turbine maintenance policy: A statistical methodology to prove interdependency between number of starts and running hours. In: Proceedings of ASME Turbo Expo 2002: Power for Land, Sea and Air. Amsterdam, Netherlands: GT2002-30281; 2002\n'},{id:"B12",body:'\nEshati S, Abdul Ghafir M, Laskaridis P, Li Y. Impact of operating conditions and design parameters on gas turbine hot section creep life. In: Proceedings of ASME Turbo Expo 2010: Power for Land, Sea and Air. Glasgow, UK: GT2010-22334; 2010\n'},{id:"B13",body:'\nMaccio M, Rebizzo A, Traversone L, Bordo L. Rotor components life evaluation validated by field operation data. In: Proceedings of ASME Turbo Expo 2010: Power for Land, Sea and Air. Glasgow, UK: GT2010-22741; 2010\n'},{id:"B14",body:'\nOleynik A. Concepts and development of methods for lifetime monitoring based on the identification of the dynamics of the thermal-stress conditions of aviation GTE critical components [thesis]. National Aerospace University of Ukraine; 2006\n'},{id:"B15",body:'\nJiang L, Eli H, Hee-Koo M. 3D rams prediction of gas-side heat transfer coefficients on turbine blade and end wall. In: Proceedings of ASME Turbo Expo 2011: Power for Land, Sea and Air. Vancouver, Canada: GT2011-46723; 2011\n'},{id:"B16",body:'\nAbubakar M, Reyad A, Gordon E, John E. Conjugate heat transfer CFD predictions of impingement heat transfer: Influence of the number of holes for a constant pitch to diameter ratio X/D. In: Proceedings of ASME Turbo Expo 2014: Power for Land, Sea and Air. Dusseldorf, Germany: GT2014-25268; 2014\n'},{id:"B17",body:'\nWieslaw B, Zhong Z, David D, Chen W, Wu X. Residual life assessment of a critical component of a gas turbine – Achievements and challenges. In: Proceedings of ASME Turbo Expo 2014: Power for Land, Sea and Air. Dusseldorf, Germany: GT2014-26423; 2014\n'},{id:"B18",body:'\nYepifanov S, Kuzmenko B, Ryumshin N. Synthesis of Turbine Engine Control and Diagnosing Systems. Kiev, Ukraine: Technical Publishing; 1998\n'},{id:"B19",body:'\nMaravilla C, Yepifanov S, Loboda I. Improved turbine blade lifetime prediction. In: Proceedings of ASME Turbo Expo 2015: Power for Land, Sea and Air. Montreal, Canada: GT2015-43046; 2015\n'},{id:"B20",body:'\nKulagin B. Theory and Design of Aircraft Engines and Power Pants. Moscow: Mashinostroenie; 2003. p. 616\n'},{id:"B21",body:'\nMaravilla C. Improvement in the prediction of the thermal boundary conditions in a turbine blade monitoring system [thesis]. National Aerospace University of Ukraine; 2016\n'},{id:"B22",body:'\nKrykonov D. Handbook of Engine Lifetime Prediction. Kharkiv, Ukraine: National Aerospace University of Ukraine; 2005. p. 67\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Cristhian Maravilla",address:"cris_mahe@hotmail.com",affiliation:'
National Aerospace University of Ukraine, Kharkiv, Ukraine
National Aerospace University of Ukraine, Kharkiv, Ukraine
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1. Introduction
At the time this chapter is being written, the world is still experiencing the Severe Acute Respiratory Syndrome Coronavirus −2 (SARS-CoV-2)/COVID-19 pandemic. The dominant circulating strain of the virus has gone under multiple changes during the pandemic. The initial ancestral strain gave way to the alpha strain which gave way to the delta and omicron strain, which are currently the dominating circulating strains [1]. In addition, there have been emergence of other variants of interests (VOIs) or variants of concern (VOC) such as beta, gamma, P1, P2, lambda, and mu which could be a threat to international health security [1]. The emergence of these variants suggests virus adaptations to various determinants, responsible for the selection of these mutated variants.
This perspective chapter considers different biological determinants capable to contribute to viral mutations and thereby, emergence of new variants and the potential impact of this on the tools (vaccines and antibody therapy) against the SARS-CoV-2. However, it is important to note the determinants mentioned here may not be an exhaustive list of potential mechanisms to induce mutations. This chapter is based on theoretical and fundamental scientific concepts known to be involved from past outbreaks or current case reports from the ongoing pandemic. It is known that biological and environmental, among other determinants may drive viral mutations by different processes or mechanisms. Furthermore, by considering the roles these potential determinants may or already contribute to future SARS-CoV-2 variants we can improve global pandemic responses, saves lives, and contribute to the international health security.
2. Methods
A scoping literature review in search for current topics associated with SARS-CoV-2 or COVID-19 viral replication, adaptations, and biological determinants known to cause variant emergence (e.g., molecular factors, animal reservoirs, immunological factors, etc.) was conducted in biomedical databases such as PubMed, MEDLINE, and Google search engine. Additionally, World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), and Food and Drug Administration (FDA) websites were relied upon to get the most recent information related to content of the chapter. Papers related to the biological determinants commonly associated with viral replication, recombination, adaptation, and immunological seletion were chosen based on the scope of the chapter. Biological determinants of variant emergence and their possible or current implications on the COVID-19 pandemic are presented below.
3. Biological determinants of SARS-CoV-2 variants emergence
3.1 Molecular determinants
3.1.1 Viral replication/recombination
SARS-CoV-2, a beta coronavirus, is a RNA virus using an error-prone RNA-dependent RNA polymerase for replication [2]. The virus encodes a proofreading 3′ exonuclease (nsp140) but despite this activity, it accumulates genomic changes having a potential to create heterogenous mixture of antigenic proteins resulting in emergence of new variants [2]. The genomic mutation rate of SARS-CoV-2 in humans is estimated at 0.8–2.38 x 10−3 nucleotide substitutions per site per year with experimental data suggesting the virus capable of mutating and accumulating changes when it encounters new cell types [3, 4]. Thus, high viral load means high viral replication and thus higher potential for genomic errors due to replication. Along with the replication associated changes, dramatic changes in the virus phenotype can be observed due to genomic recombination in a cell infected with more than one coronavirus [2, 5]. Till now eight recombination events have been observed in SARS-CoV-2 but the frequency of such events is not known [6]. Random errors accumulated during replication/recombination along with population level natural and vaccine induced immunity, play an important role in Darwinian selection of these variants [2].
3.2 Zoonotic determinants
Although the exact precursor of SARS-CoV-2 is unknown, it is established it is of wild origin. The initial December 2019 outbreak in Wuhan, China was linked to the seafood and live animal city market [7]. This market was reported to trade poultry, snakes, hedgehogs, and other wild animals [8].
The different SARS-CoV-2 variants detected in animals including dogs, cats, tigers, lions, minks, and gorillas all had genomes related to the human variant yet had additional mutations. The presence and infection of these animal reservoirs with SARS-CoV-2 virus also increases the possibility of viral mutations/recombinations and emergence of variants. Zoonotic reservoirs capable of carrying and providing an environment for viral multiplication are listed below.
3.2.1 Bats and pangolins
At the beginning of the pandemic bats were declared as the possible SARS-CoV-2 reservoir because of the genomic similarities with other coronaviruses infecting bats [9]. During the initial molecular epidemiological investigations, it was found the SARS-CoV-2 genome had similarities with coronaviruses isolated in Rhinolophus bats [10]. In Cambodia, a coronavirus with 93% genomic similarities was detected in horseshoe bats Rhinolophus shameli, but this specific bat species does not reside at the location of original SARS-CoV-2 outbreak [11, 12]. Similarly, 200 novel coronaviruses have been identified among bats worldwide [13]. Furthermore, bats are reservoirs for other emerging pathogens like Ebola, Nipah, rabies, Hendra, and rotaviruses [14]. Nevertheless, there are three events contradicting the hypothesis that bats were the initial reservoir from which SARS-CoV-2 jumped into other species: 1) during the beginning of the pandemic bats were hibernating; 2) bats were not sold at the animal market during the initial outbreak; and 3) although other bat coronaviruses have up to 96% genomic similarities, SARS-CoV-2 has not been detected among bat species [15].
The fist isolated variant of SARS-CoV-2 was identified as pangolin-CoV because of similarities with coronaviruses isolated in the carcasses of Malayan pangolins Manis javanica [16]. SARS-CoV-2 has 89% nucleotide and 98% amino acid similarities with the pangolin coronavirus genome [17]. Moreover, recent investigations done in other pangolin species conclude the pangolin coronavirus can be the precursor of SARS-CoV-2 because of their high genetic variation and given no coronaviruses were found in pre-COVID-19 pangolin samples [18].
3.2.2 SARS-CoV-2 variants in domestic and wild animals
The virus has been detected in domestic cats and dogs [14]. Therefore, the transmission from humans to domestic animals is plausible. Specifically, the B.1.1.7 (Alpha) variant has been identified in domestic cats as well as in domestic dogs [19]. In contrast it appears that cattle, goats, and sheep are not infected by the virus [20].
Among animals kept in zoos the virus has been detected in gorillas, tigers, pumas, cougars, Asian small-clawed otters, and snow leopards. The genetic variability of SARS-CoV-2 is evident from the 9 genomes identified in tigers, lions, and their keepers [21]. The B.1.1.7 (Alpha) variant has been detected in gorillas, lions, leopards, and tigers [20, 22]. In another study the B.1.617.2 (Delta) variant was reported in Asiatic lions from India [23]. Farmed wild animals have been diagnosed with SARS-CoV-2. Specifically, SARS-CoV-2 has been identified in American minks (Neovison vison) and in ferrets (Musteal furo) [20].
Therefore, this possibility of emergence of new variants is ever present due to SARS-CoV-2 spread to different ecological environments and newer animal reservoirs resulting in a subsequent risk for spillover into humans and other species.
3.3 Immunological determinants
3.3.1 Herd immunity
Lately, the phrase “Herd Immunity” is constantly brought up in news outlets, in commentaries, opinion pieces, and peer-reviewed articles. First introduced almost 100 years ago, it only recently gained popularity [24]. Although Herd Immunity is now a widely accepted concept, it may take on multiple meanings, each slightly different than the next. Some researchers consider Herd Immunity a threshold of the proportion of immune individuals that leads to a decline in infections or outbreaks [25, 26]. While others may use it to describe the proportion immune to a specific infection among a population or refer to it as a protective immunity pattern [25]. Herd Immunity is most referred to as the reduction of risk, of an infection, to susceptible individuals by the proximity and presence of immune individuals [25]. Herd Immunity may be used interchangeably as “indirect protection” or “herd effect”. Regardless of the definition variations, Herd Immunity leads to one outcome – the reduction of infection incidence. This concept, in conjunction with vaccines, has contributed to some of the most important public health achievements in the 20th and 21st century such as the smallpox eradication, polio elimination, and other vaccine-preventable diseases. This section explores the concepts behind Herd Immunity and current and future implications during the COVID-19 pandemic.
3.3.1.1 Theories which constructed herd immunity
Topley and Wilson (1923) were the first to coin the term “Herd Immunity” and specifically look at host resistance in comparison with mass infection. After first mention of Herd Immunity, the term and overall concept started appearing and developing soon after [27, 28, 29]. Dudley [27] explored the idea of a “herd” or community and how it could be defined. He defined the idea of “infection pressure” (i.e., fundamental parasite factor) which may be determined by the infectious agent distribution frequency rates which is in the members of the herd [27]. He claimed, infectious pressure reacts with Herd Immunity, the increase of one increases the other and then decreases it to zero. This introduced the idea of needing a minimum amount of Herd Immunity, a threshold, in order to keep the infectious pressure at zero. Furthermore, he mentioned those two factors contributed to the type, quantity, infection speed (i.e., now known as R0) and the frequency and distribution of cases and their severity [27].
Yet Herd Immunity had one large limitation—to provide protection, a high proportion of the population must be immune to the pathogen. Before immunizations individuals had to survive and pass the pathogen to become immune; depending on the pathogen, likelihood of survival and being left with life-altering morbidities varied. However, as concepts behind Herd Immunity were evolving, vaccinations were becoming a staple of public health practice, allowing a large proportion of the population to be safely immunized against specific pathogens. Vaccination allowed for the fulfillment of Herd Immunity at a much faster rate and safer manner. This allowed for the concepts to be turned into mathematical possibilities.
Before vaccination and Herd Immunity there were two main hypotheses as to why outbreaks would end even though not all susceptible were affected: (1) the agent naturally loses virulence (2) the dynamics between susceptible, infected, and immune [26]. The later hypothesis, prevailed with its mathematical idea of “mass action principle” (MAP) [26]. This principle was based on a simple logical argument in favor of indirect protection given by Herd Immunity and became an epidemiological theoretical cornerstone. Eventually three theories converged into one general theory driving Herd Immunity: MAP, case reproduction rates (later called base reproductive rates [BRR]), and the Reed-Frost heterogenous population simulation approach [26]. The current formula used for Herd Immunity is H = 1–1/R0 = (R0–1)/R0, where R0 is the BRR. H is the Herd Immunity threshold, the proportion of immunes needed in order to reduce incidence and R0 is derived from the duration of contagiousness of an infected individual, the likelihood of infection per contact between a susceptible person and an infectious person or vector, and the contact rate [30]. The BRR serves as an indicator of the contagiousness of an infectious agent—the higher the R0, the more transmissible. An R0 > 1 indicates an outbreak will continue, while a R0 < 1 indicates the end of an outbreak, if R0 = 1 then the outbreak is stable [30]. In novel outbreaks, where everyone is susceptible the R0 defines the infectiousness of a pathogen. However, as individuals pass the infection or become immunized, the number of susceptible decreases and immune increases, and although this does not technically reduce the BRR, because the definition of R0 assumes a completely susceptible population, one can use the effective reproduction number (R) in lieu, which is similar to R0 but does not assume complete population susceptibility and, thus, can be estimated with populations with immune members [30]. Efforts aimed at reducing the number of susceptible persons through vaccination would result in a reduction of the R value, rather than R0 value.
3.3.1.2 Herd immunity in the context of COVID-19
Currently there are multiple vaccines approved internationally for human use and immunization campaigns are urging communities to get vaccinated, therefore reducing the number of susceptible in hopes to achieve herd immunity. However, there are multiple factors to consider in achieving herd immunity from the SARS-CoV-2 virus.
Originally, with an estimated BRR of 2–3, researchers estimated the proportion of the population needed to be immunized to induce Herd Immunity around 50–67% [31, 32, 33]. Since then, the emergence of new SARS-CoV-2 variants, most famously the Delta variant, studies suggest a higher BRR (>5) [34, 35] than the alpha variant (2–3) [31, 32, 33, 36, 37, 38, 39] increasing the vaccination/immune threshold needed in order to achieve a protective effect. An increase in the necessary number of individuals vaccinated propose additional hurdles in reaching Herd Immunity, with the ever-increasing anti-vax movement or individuals acting as “freeloaders” (i.e., individuals who are not vaccinated, yet expect to be protected by the rest of the community being vaccinated).
Secondly, future SARS-CoV-2 variants may mutate enough where the protection offered by the currently available vaccines or natural immunity may no longer suffice. The emergence of the Delta variant showed a reduced vaccine effectiveness compared to the previous variants, which the vaccines were developed from [40, 41]. While currently approved vaccines still provide significant protection from the Delta variant for reduced risk of infection and disease severity, the reduction in vaccine effectiveness is alarming. If emerging variants significantly or completely evade the protection offered by current vaccines or natural immunity, individuals may no longer fall under the immune proportion of the population. An example of this possible situation was reported in Manaus, Brazil, where by December 2020 the population was estimated to have naturally achieved the herd immunity threshold (i.e., before vaccinations were approved and available), estimated at 67%, yet experienced a wave of hospitalizations in January 2021 [42]. This case study further highlighted the limitations with calculating Herd Immunity. Possible reasons for the Manaus outbreak were an overestimation of the immune population, a possible waning immune response, mutants capable of evading responses from previous natural infection, and mutants may have higher transmissibility than previously circulating lineages [42]. Future scenarios where Herd Immunity may not be achievable or severely reduced would be staggering in relation to vaccination campaigns and reaching herd immunity—a grave threat to international health security.
3.3.2 Artificial immunization/natural infection
All COVID-19 vaccines authorized or have received emergency use authorization (EUA) by FDA, EU/EEA, or WHO require a two-dose schedule except for the Janssen vaccines. All these vaccines require a period of 21 days to 12 weeks spacing between the primary and secondary dose [43]. In the early phase of the pandemic to reduce widespread community transmission, logistical issues, and shortages, many countries (e.g., UK, Canada) elected to delay the second dose in the population, thereby increasing the number of individuals with at least one dose. Policies such as the aforementioned in conjunction with waning of immunity after SARS-CoV-2 natural infection may result in large groups of people with only partial immunity against SARS-CoV-2 [43].
The Darwinian selection of variants with mutations for immune escape and its transmission in the community will depend on substantial selection pressure [44]. The greatest potential for the emergence of these immune escape mutations will be in those hosts with highest viral loads (increased mutations) while the greatest selection pressure will be in those with strongest immunological response [2, 44]. The level of immunological protection conferred after first dosage is dependent on the type of vaccine product in addition to the individual characteristics and variant [43]. In individuals with poor immunological response after first dose, there is potential for greater infection burden [44]. These individuals will have higher assumed rates of evolutionary adaptation because of higher viral load and replication. In those individuals with strong but partial immunological response, the infection rates would be lower but evolutionary selection pressure would be large, resulting in high rates of viral adaptations. Previous phylogenic research done on influenza viruses suggested the viral evolution and emergence of immune escape variants is maximum in those individuals with partial immunity (i.e., intermediate levels of selection and viral replication) [45]. Thus, having partially immunized individuals could lead to short-term benefits such as reduced peak of disease but in long term can result in higher infection burden and substantially higher risk of viral evolution to immune escape variants [44].
3.3.2.1 Chemical and biological therapy
Several monoclonal antibodies were developed against the spike protein of SARS-CoV-2 to block the transmission of the virus inside the cells [46]. A single (Bamlanivimab) or combination monoclonal antibodies (Bamlanivimab/Etsevimab or Casirivimab/Imdevimab) received EUA for therapeutic management of SARS-CoV-2 and post-exposure prophylaxis [47, 48]. In theory, administration of monoclonal antibody therapy can alter the immunological selective pressure resulting in viral adaptation for the emergence of variants resistant to one or more monoclonal antibodies [49, 50]. This potential for the emergence of monoclonal antibody resistance has been observed in immunocompromised patients [51, 52, 53]. In trials for monoclonal antibodies, mutations resistant to antibodies were detected by next generation sequencing (NGS) assay in 10% of the patients receiving therapy with its transmissibility not determined [54]. Recently, a Wisconsin (WI) study using Bamlanivimab described the emergence of new resistant mutation E484K with further transmission to nearby contacts [55]. The emergence of variants with reduced susceptibility to neutralizing antibodies after polyclonal convalescent plasma therapy provides further proof of the effect of immunological selective pressure on emergence of new variants [49, 56]. It is conceivable, the widespread use of monoclonal or polyclonal antibody therapy may reduce barriers for the emergence of resistant variants to these antibodies which can further transmit to wider communities, potentially becoming a variant of concern. A widespread genomic surveillance is warranted to identify and control the spread of these antibody resistant variants [55].
3.3.3 Immunosuppressed individuals
During evaluation of the efficacy of vaccines, subjects with inhered or acquired immunodeficiencies are excluded from clinical trials. Therefore, there are limited information about the immunogenicity of SARS-CoV-2 vaccines among these patients. Field studies evaluating the effectiveness of COVID-19 vaccines demonstrate that immunocompromised subjects mount a lower antibody response when compared with immunocompetent subjects [57].
Viruses are highly sophisticated molecular machines that can go into an adaptive evolution in the human host establishing a latent reservoir, integrating into the human genome, or causing a chronic infection. Viruses such as hepatitis B virus, hepatitis C virus, and human immunodeficiency virus go into latent stage evading the host immune response while other viruses like Ebola can persist in immune sanctuaries [58]. Considering COVID-19 is an infection of pandemic proportions, it is plausible to think human host immune pressure can contribute to SARS-CoV-2 genetic diversity and selection with phenotypic changes [59]. Consequently, it is necessary to address the relationship between viral persistence in the immunosuppressed host. As a matter of fact, one of the hallmarks of SARS-CoV-2 is its capacity to co-opt various cellular factors and machineries damping the immune response [60]. Although not yet demonstrated, it is plausible to suggest SARS-CoV-2 may establish a latent infection or remain in immune sanctuary. However, SARS-CoV-2 persistence in the immunocompromised patient is well documented [61, 62], with viral persistence reported among cancer patients and transplant recipients [61, 63, 64, 65, 66, 67]. Viral coronavirus RNA has been detected up to ~60 days in cancer patients that developed respiratory symptoms. Moreover, the longest persistence of coronavirus RNA is recorded at 151 days in a patient with anti-phospholipid syndrome, which suggest these pathogens are of the opportunistic characteristic [68, 69, 70]. In the aforementioned patient, there were 31 substitutions and 3 deletions identified in the genome sequencies from the isolated agent. There were 12 mutations in the spike protein including 7 in the receptor-binding domain segment. Due to severe pulmonary complication the patient died [71]. Increased viral changes were also detected in another immunocompromised patient, whose disease prolonged for 101 days, where viral changes were limited during the first 60 days but increased after receiving plasma form a convalescent patient at days 63 and 65. Moreover, rapid shifts were observed in the spike area during the last days of the monitoring [71]. In another case-series, three patients receiving chimeric antigen receptor (CAR) T cells because of B-cell acute lymphocytic leukemia, showed multiple escape SARS-CoV-2 variants [71]. Consequently, like SARS-CoV-2 longer persistence in immunosuppressed patients, immunosusceptible elderly patients may also harbor the virus for prolonged periods compared to immunocompetent patients. Gaspar-Rodriguez et al. enunciated in 2021 that SARS-CoV-2 and other coronaviruses potentially establish a long-term, non-productive persistent infection in epithelial, myeloid, and neural host cells until viral clearance is achieved [62]. Prolonged COVID-19 in the immunosuppressed patient can be a determinant of the development of SARS-CoV-2 variants which can be spread among the general population [71]. This persistence of the virus in different types of immunosuppression are listed below.
3.3.3.1 SARS-CoV-2 in Cancer patients
Cancer patients are in immunodepression conditions because of the malignancy and oncological treatments like chemotherapy, radiotherapy, transplants, and immunotherapy. Patients with lung, blood, and bone marrow carcinomas are at a higher risk of harboring the virus for prolonged periods when compared with other cancer patients [72]. Patients with chronic lymphocytic leukemia (CLL) have shown inadequate levels of antibodies as well as cellular immune response [73]. These inadequate immune responses in CLL patients correlates with severe and prolonged forms of COVID-19 and has been supported by late conversion to negative PCR monitoring tests and longer hospitalizations [74]. The impaired humoral and cellular immune response in the CLL patients make these patients long term shedders of SARS-CoV-2 until infection is passed. One case study showed a COVID-19 positive CLL patient having persistent positive PCR test for 105 days after diagnosis [63]. Moreover, during this period a continuous variability in predominant viral variants was observed [63]. This delay in viral clearance in COVID-19 patients has been observed in patients receiving intravenous immunoglobulins as well as in those with hypertension [75].
3.3.3.2 SARS-CoV-2 in organ transplant patients
Organ transplant recipients are patients with long-lasting immunosuppression; therefore, organ transplant recipients have been declared subjects with high risk for severe COVID-19. When COVID-19 positive liver transplant patients were compared with COVID-19 immunocompetent patients, the transplant recipients showed lower prevalence of antibodies against SARS-CoV-2, as well as a faster antibody decline [57]. Regarding viral shedding, immunocompetent asymptomatic COVID-19 infection subjects experience a faster viral clearance when compared with symptomatic individuals [76]. Kidney transplant patients with immunosuppression showed a longer shedding of the virus, of more than 28 days, which was correlated with a prolongation of symptoms [77].
3.3.3.3 SARS-CoV-2 in elderly patients
It is demonstrated SARS-CoV-2 causes highest mortality among elderly populations. Also, viral shedding is increased, enhancing the spread of the virus as it was observed in the increased transmission in nursing homes. An explanation for these complications may be due to the elderly immune system being less competent than in young populations. In the elderly, it appears the production of cytokine and T-cells production worsen the inflammation process especially among those with comorbidities [78]. The increased shedding of SARS-CoV-2 is associated with a more severe clinical presentation and higher viral load peaks [79, 80, 81]. The delayed viral clearance in elderly patients’ airways can be explained by a decreased respiratory muscle function and diminished mucociliary function [79, 82].
3.3.3.4 SARS-CoV-2 in patients with corticosteroid treatment
Although corticosteroid therapy is being used to ameliorate the inflammation process, the use of corticosteroids at an early stage can suppress the immune cells which can prolong the clearance of the virus as well as its shedding. In a randomized study in the patients without respiratory failure, the methylprednisolone group showed a median viral shedding of 10 days vs. 6 days in the control group [83].
4. Discussion
The molecular mechanisms of viral replication, multiple animal reservoirs, and immunological selection methods have the possibility for viral evolution to immune escape variants (Figure 1). Such epidemiological and evolutionary mechanisms are already seen in the emergence of different VOC worldwide [44].
Figure 1.
Biological determinants of emergence of SARS-CoV-2 variants. An infection of SARS-CoV-2 in humans results in viral replication. In born errors of viral replication or genomic recombination can result in viral mutations. People with natural/artificial immunity will neutralize the non-mutated virus but has non-neutralizing immune response against mutated variant. Mutated SARS-CoV-2 thus undergoes this immunological selection for emergence of SARS-CoV-2 variant. Infection in animals with different host cell machinery led to mutated SARS-CoV-2 with potential for species jump and spillover into humans and emergence of SARS-CoV-2 variant.
4.1 Impact of emergence of new variants on vaccine
Since the beginning of the pandemic, VOC having selective advantage of more transmissibility and resistance to natural or vaccine induced immunity have been evolving and supplanting previously circulating strains [43, 84]. The emergence of these VOC affects the effectiveness of vaccines in both partially and fully immunized individuals [43]. In vitro studies demonstrated lower neutralization capacity against all VOC compared to ancestral strains [41, 85, 86]. Based on evidence available for all vaccine types, partially immunized individuals have a lower degree of protection against symptomatic infection, moderate disease, and probable transmission with Delta VOC than Alpha VOC. In general, the vaccine effectiveness for all variants against symptomatic disease was much lower than those reported against severe diseases. The fully immunized individuals confer nearly equivalent protection for all outcomes against Alpha to that of Delta variants [43]. Table 1 summarizes the results of vaccine effectiveness by type of vaccine, outcome, and VOC.
Variant
Original
Original
Alpha
Beta
Gamma
Delta
Delta
Vaccine
SI
SD
SI
SI
SI
SI
SD
Comirnaty (Pfizer/BioNTech)
95%
100%
89.5%
75%
61%
87.9%
96%
SpikeVax (Moderna)
94.1%
100%
↓ Ant Neu
↓ Ant Neu
↓ Ant Neu
↓ Ant Neu
Vaxzeria (AstraZeneca)
70.4%
81.3%
66.1%
10.4%
↓ Ant Neu
59.8%
92%
Johnson & Johnson
74.2%
85.4%
64%
↓ Ant Neu
Cansino
90–95%
Sputnik V
91.6%
100%
No difference
↓ Ant Neu
Sinovac
78.1%
100%
↓ Ant Neu
↓ Ant Neu
↓ Ant Neu
Soberana (Cuba)
62%
Table 1.
Vaccine effectiveness of two dose of vaccines against symptomatic infection and severe disease caused by non-VOCs, alpha, and Delta VOCs.
SI, symptomatic disease; SD, Severe disease.
The emergence of new vaccine-resistant variants may necessitate the development of modified vaccines based on new sequences to prevent the prolonged circulation of vaccine-resistant variants [84]. It is important to conduct studies of these modified vaccines to determine its efficacy in developing a neutralizing immunological response against vaccine-resistant variants. This research is important despite the deployment of these newer vaccines not required until there is evidence of failure of current vaccines. Once the modified vaccines are introduced the molecular and immunological determinants of viral adaptation will necessitate to repeat the cycle of monitoring for even newer variants that might require further modifications in the antigenic sequence in vaccines.
4.2 Impact of emergence of new variants antibody therapy
Like vaccines, the viral adaptations seen against the monoclonal antibody therapy can complicate the deployment of these treatments at large scale in the general population [55]. The initial widespread use of Bamlanivimab as a single therapy and later removal due to epidemiologic trend further provides evidence for judicious use of monoclonal antibody therapy [87]. The usage of cocktail of antibodies should in theory reduce the probability of random selection of resistant variants however it does not totally remove this possibility [55]. This combined with monoclonal antibodies not preventing transmission, not providing immediate cure, lacking durable immunity, and potentially leading to antibody strains with some cross-resistance against vaccine or natural-acquired immunity suggests the need for caution before widespread usage of monoclonal antibody therapy [41, 55]. Increasing the scale of surveillance for mutations along with research into monoclonal antibodies against newer antigens should be adopted if the scale of use of monoclonal antibody has to be expanded [55].
Thus, the determinants of emergence of SARS-CoV-2 variants necessitates the inclusion of epidemiological, evolutionary, clinical, animal, and in vitro data related to changing antigenic sequences, vaccine and monoclonal antibody efficacy in the decision making of which antigens to be included in vaccines or targeted for therapy [84]. Lastly, it is important to recognize the limitations of the concepts presented in this chapter. This is a prospective chapter piece using concepts and theoretical ideologies commonly attributed to variant emergence. The inclusion of the determinants presented are a combination of expert knowledge on behalf of the authors and a scoping literature review conducted on SARS-CoV-2 and its current variants, therefore, this chapter is not meant to replace a systematic review.
5. Conclusion
This chapter presents theoretical and current determinants for variant emergence, specifically for SAR-CoV-2. The emergence of different VOC through the evolutionary cycle of the SARS-CoV-2 virus during the current pandemic (2019- ongoing) makes it important to understand the biological determinants of new emerging variants. The inherent errors in viral replication in humans and animal reservoirs combined with immunological selective pressure result in the Darwinian selection of variants of SARS-CoV-2 with potential for higher transmissibility and resistance to vaccine-based immunity or monoclonal antibodies. The different types of vaccines and associated immune response, partial immunization, waning of immunity, and heterogenicity in worldwide immunity results in wide differences in immunological selective pressure based on regions and virus evolutions. The global inequality in vaccine distribution further complicates this immunological selection pressure. The epidemiological and evolutionary cycle can result in viral adaptations with potential for selection of variants with higher transmissibility and immune escape properties. The emergence of these dangerous new variants can influence vaccine and antibody therapy effectiveness necessitating modifications in antigenic sequences used in production. This emergence of novel variants thus is a concern for international health security with a potential for furthering the COVID-19 pandemic and its associated negative health, economic, and social effects.
\n',keywords:"SARS-CoV-2, COVID-19, variants, determinants",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/81865.pdf",chapterXML:"https://mts.intechopen.com/source/xml/81865.xml",downloadPdfUrl:"/chapter/pdf-download/81865",previewPdfUrl:"/chapter/pdf-preview/81865",totalDownloads:9,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 8th 2021",dateReviewed:"March 31st 2022",datePrePublished:"May 19th 2022",datePublished:null,dateFinished:"May 19th 2022",readingETA:"0",abstract:"In epidemic and pandemic circumstances, mutant RNA viruses go into a Darwinian selection of species with the predominance of the most transmissible, pathogenic, and virulent variants. Nevertheless, our current knowledge about the determinants of emergence of the new mutants is limited. The perspective chapter presents theoretical concepts related to biological determinants responsible for viral mutations or potential variant emergence. A scoping literature review was done in biomedical databases (PubMed, Medline) and google search engine with papers selected based about the book chapter. Public health and governmental agency websites were utilized for most recent information. Molecular determinants, the heterogenic herd immunity achieved by world populations, partial induced natural immunity by the disease, partial artificial immunity caused by incomplete immunization schedules, animal reservoirs, immunosuppression and chemical and biological antiviral therapies can result in genomic mutations combined with immunological selective pressure resulting in emergence of variants of concern. These variants could be resistant to current vaccines and monoclonal antibodies and can influence the future directions of the COVID-19 pandemic. This can be a threat to international health security and thus it is important to increase the genomic surveillance for mutations and research into modified vaccines and monoclonal antibodies against newer antigens to prevent the prolongation of the pandemic.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81865",risUrl:"/chapter/ris/81865",signatures:"Ricardo Izurieta, Tatiana Gardellini, Adriana Campos and Jeegan Parikh",book:{id:"11113",type:"book",title:"Contemporary Developments and Perspectives in International Health Security - Volume 3",subtitle:null,fullTitle:"Contemporary Developments and Perspectives in International Health Security - Volume 3",slug:null,publishedDate:null,bookSignature:"Dr. Stanislaw P. Stawicki and Prof. Ricardo Izurieta",coverURL:"https://cdn.intechopen.com/books/images_new/11113.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-837-8",printIsbn:"978-1-83969-836-1",pdfIsbn:"978-1-83969-838-5",isAvailableForWebshopOrdering:!0,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"336849",title:"Prof.",name:"Ricardo",middleName:null,surname:"Izurieta",fullName:"Ricardo Izurieta",slug:"ricardo-izurieta",email:"rizuriet@health.usf.edu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/293169/images/system/293169.png",institution:{name:"University of South Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"336851",title:"MSc.",name:"Adriana",middleName:null,surname:"Campos",fullName:"Adriana Campos",slug:"adriana-campos",email:"elba@usf.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of South Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"336852",title:"Dr.",name:"Jeegan",middleName:null,surname:"Parikh",fullName:"Jeegan Parikh",slug:"jeegan-parikh",email:"jeeganparikh@usf.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of South Florida",institutionURL:null,country:{name:"United States of America"}}},{id:"336859",title:null,name:"Tatiana",middleName:null,surname:"Gardellini Guevara",fullName:"Tatiana Gardellini Guevara",slug:"tatiana-gardellini-guevara",email:"tgardell@usf.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methods",level:"1"},{id:"sec_3",title:"3. Biological determinants of SARS-CoV-2 variants emergence",level:"1"},{id:"sec_3_2",title:"3.1 Molecular determinants",level:"2"},{id:"sec_3_3",title:"3.1.1 Viral replication/recombination",level:"3"},{id:"sec_5_2",title:"3.2 Zoonotic determinants",level:"2"},{id:"sec_5_3",title:"3.2.1 Bats and pangolins",level:"3"},{id:"sec_6_3",title:"3.2.2 SARS-CoV-2 variants in domestic and wild animals",level:"3"},{id:"sec_8_2",title:"3.3 Immunological determinants",level:"2"},{id:"sec_8_3",title:"3.3.1 Herd immunity",level:"3"},{id:"sec_8_4",title:"3.3.1.1 Theories which constructed herd immunity",level:"4"},{id:"sec_9_4",title:"3.3.1.2 Herd immunity in the context of COVID-19",level:"4"},{id:"sec_11_3",title:"3.3.2 Artificial immunization/natural infection",level:"3"},{id:"sec_11_4",title:"3.3.2.1 Chemical and biological therapy",level:"4"},{id:"sec_13_3",title:"3.3.3 Immunosuppressed individuals",level:"3"},{id:"sec_13_4",title:"3.3.3.1 SARS-CoV-2 in Cancer patients",level:"4"},{id:"sec_14_4",title:"3.3.3.2 SARS-CoV-2 in organ transplant patients",level:"4"},{id:"sec_15_4",title:"3.3.3.3 SARS-CoV-2 in elderly patients",level:"4"},{id:"sec_16_4",title:"3.3.3.4 SARS-CoV-2 in patients with corticosteroid treatment",level:"4"},{id:"sec_20",title:"4. Discussion",level:"1"},{id:"sec_20_2",title:"4.1 Impact of emergence of new variants on vaccine",level:"2"},{id:"sec_21_2",title:"4.2 Impact of emergence of new variants antibody therapy",level:"2"},{id:"sec_23",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'World Health Organization. Tracking SARS-CoV-2 variants. 2021. Available from: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/ [Accessed 31-10-2021]'},{id:"B2",body:'Banerjee A, Mossman K, Grandvaux N. Molecular determinants of SARS-CoV-2 variants. Trends in Microbiology. 2021;29(10):871-873'},{id:"B3",body:'Massimo A.et al. Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution, Evolution, Medicine, and Public Health. 2022;10(1):142-155'},{id:"B4",body:'De Maio N et al. Mutation rates and selection on synonymous mutations in SARS-CoV-2. Genome Biology and Evolution. 2021;13(5):1-14'},{id:"B5",body:'Lai MM et al. 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Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization. Nature. 2021;596(7871):276-280'},{id:"B42",body:'Sabino EC et al. Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence. Lancet. 2021;397(10273):452-455'},{id:"B43",body:'European Center for Disease Control and Prevention. Partial COVID-19 Vaccination, Vaccination Following SARS-CoV-2 Infection and Heterologous Vaccination Schedule: Summary of Evidence. ECDC: Stockholm; 2021'},{id:"B44",body:'Saad-Roy CM et al. Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes. Science. 2021;372(6540):363-370'},{id:"B45",body:'Grenfell BT et al. Unifying the epidemiological and evolutionary dynamics of pathogens. Science. 2004;303(5656):327-332'},{id:"B46",body:'Lloyd EC, Gandhi TN, Petty LA. Monoclonal antibodies for COVID-19. JAMA. 2021;325(10):1015-1015'},{id:"B47",body:'U.S. Food and Drug Adminsitration. FDA Authorizes Monoclonal Antibodies for Treatment of COVID-19. 2020'},{id:"B48",body:'U.S. Food and Drug Adminsitration, FDA authorizes bamlanivimab and etesevimab monoclonal antibody therapy for post-exposure prophylaxis (prevention) for COVID-19. 2021'},{id:"B49",body:'Colson P et al. A possible role of Remdesivir and plasma therapy in the selective sweep and emergence of new SARS-CoV-2 variants. Journal of Clinical Medicine. 2021;10(15):3276'},{id:"B50",body:'Kreuzberger N et al. SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19. Cochrane Database of Systematic Reviews. 2021;9(9):Cd013825'},{id:"B51",body:'Jensen B et al. Emergence of the E484K mutation in SARS-COV-2-infected immunocompromised patients treated with bamlanivimab in Germany. The Lancet Regional Health–Europe. 2021;8:100164'},{id:"B52",body:'Lohr B et al. Bamlanivimab Treatment Leads to Rapid Selection of Immune Escape Variant Carrying the E484K Mutation in a B.1.1.7-Infected and Immunosuppressed Patient. Clinical Infectious Diseases. 6 Dec 2021;73(11):2144-2145'},{id:"B53",body:'Peiffer-Smadja N et al. Emergence of E484K mutation following Bamlanivimab monotherapy among High-risk patients infected with the alpha variant of SARS-CoV-2. Viruses.2021;13(8):1642'},{id:"B54",body:'Chen P et al. SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19. New England Journal of Medicine. 2020;384(3):229-237'},{id:"B55",body:'Sabin AP et al. Acquisition and onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab- treated patient. medRxiv. 2021: 1-14. https://doi.org/10.1101/2021.10.02.21264415'},{id:"B56",body:'Andreano E et al. SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma. Proceedings of the National Academy of Sciences. 2021;118(36):e2103154118'},{id:"B57",body:'Deborska-Materkowska D, Kaminska D. The immunology of SARS-CoV-2 infection and vaccines in solid organ transplant recipients. Viruses. 2021;13(9):1879'},{id:"B58",body:'Zhou Y et al. Viral (hepatitis C virus, hepatitis B virus, HIV) persistence and immune homeostasis. Immunology. 2014;143(3):319-330'},{id:"B59",body:'Centers for Disease Control and Prevention. Science Brief: Emerging SARS-CoV-2 Variants. 2021. Available from: https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-emerging-variants.html [Accessed 30-10-2021]'},{id:"B60",body:'Desimmie BA et al. Insights into SARS-CoV-2 persistence and its relevance. Viruses. 2021;13(6):1025'},{id:"B61",body:'Fung M, Babik JM. COVID-19 in immunocompromised hosts: What we know so far. Clinical Infectious Diseases. 2021;72(2):340-350'},{id:"B62",body:'Gaspar-Rodriguez A, Padilla-Gonzalez A, Rivera-Toledo E. Coronavirus persistence in human respiratory tract and cell culture: An overview. The Brazilian Journal of Infectious Diseases. 2021;25(5):101632'},{id:"B63",body:'Avanzato VA et al. Case study: Prolonged infectious SARS-CoV-2 shedding from an asymptomatic immunocompromised individual with Cancer. Cell. 2020;183(7):1901-1912 e9'},{id:"B64",body:'Decker A et al. Prolonged SARS-CoV-2 shedding and mild course of COVID-19 in a patient after recent heart transplantation. American Journal of Transplantation. 2020;20(11):3239-3245'},{id:"B65",body:'Moore JL et al. A 63-year-old woman with a history of non-Hodgkin lymphoma with persistent SARS-CoV-2 infection who was seronegative and treated with convalescent plasma. American Journal of Case Reports. 2020;21:e927812'},{id:"B66",body:'Nakajima Y et al. Prolonged viral shedding of SARS-CoV-2 in an immunocompromised patient. Journal of Infection and Chemotherapy. 2021;27(2):387-389'},{id:"B67",body:'Wei L et al. Prolonged shedding of SARS-CoV-2 in an elderly liver transplant patient infected by COVID-19: A case report. Annals of Palliative Medicine. 2021;10(6):7003-7007'},{id:"B68",body:'Choi B et al. Persistence and evolution of SARS-CoV-2 in an immunocompromised host. New England Journal of Medicine. 2020;383(23):2291-2293'},{id:"B69",body:'Dominguez SR, Robinson CC, Holmes KV. Detection of four human coronaviruses in respiratory infections in children: A one-year study in Colorado. Journal of Medical Virology. 2009;81(9):1597-1604'},{id:"B70",body:'Ogimi C et al. Prolonged shedding of human coronavirus in hematopoietic cell transplant recipients: Risk factors and viral genome evolution. The Journal of Infectious Diseases. 2017;216(2):203-209'},{id:"B71",body:'Corey L et al. SARS-CoV-2 variants in patients with immunosuppression. New England Journal of Medicine. 2021;385(6):562-566'},{id:"B72",body:'Pratapa SK et al. Caring for Cancer patients during Corona pandemic-(COVID-19)-a narrative review. South Asian Journal of Cancer. 2021;10(1):19-22'},{id:"B73",body:'Mihaila RG. Management of patients with chronic lymphocytic leukemia during the SARS-CoV-2 pandemic. Oncology Letters. 2021;22(2):636'},{id:"B74",body:'Paneesha S et al. Covid-19 infection in therapy-naive patients with B-cell chronic lymphocytic leukemia. Leukemia Research. 2020;93:106366'},{id:"B75",body:'Chen X et al. Risk factors for the delayed viral clearance in COVID-19 patients. Journal of Clinical Hypertension (Greenwich, Conn.). 2021;23(8):1483-1489'},{id:"B76",body:'Cevik M et al. SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: A systematic review and meta-analysis. The Lancet Microbe. 2021;2(1):e13-e22'},{id:"B77",body:'Laracy JC, Miko BA, Pereira MR. The solid organ transplant recipient with SARS-CoV-2 infection. Current Opinion in Organ Transplantation. 2021;26(4):412-418'},{id:"B78",body:'Smorenberg A et al. How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity. European Journal of Internal Medicine. 2021;83:1-5'},{id:"B79",body:'Ho JC et al. The effect of aging on nasal Mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia. American Journal of Respiratory and Critical Care Medicine. 2001;163(4):983-988'},{id:"B80",body:'Liu Y et al. Viral dynamics in mild and severe cases of COVID-19. The Lancet Infectious Diseases. 2020;20(6):656-657'},{id:"B81",body:'To KK-W et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: An observational cohort study. The Lancet Infectious Diseases. 2020;20(5):565-574'},{id:"B82",body:'Svartengren M, Falk R, Philipson K. Long-term clearance from small airways decreases with age. The European Respiratory Journal. 2005;26(4):609-615'},{id:"B83",body:'Tang X et al. Early use of corticosteroid may prolong SARS-CoV-2 shedding in non-intensive care unit patients with COVID-19 pneumonia: A Multicenter, single-blind, randomized control trial. Respiration. 2021;100(2):116-126'},{id:"B84",body:'Krause PR et al. SARS-CoV-2 variants and vaccines. New England Journal of Medicine. 2021;385(2):179-186'},{id:"B85",body:'Liu C et al. Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell. 2021;184(16):4220-4236.e13'},{id:"B86",body:'Yadav PD et al. Neutralization of Beta and Delta variant with sera of COVID-19 recovered cases and vaccinees of inactivated COVID-19 vaccine BBV152/Covaxin. Journal of Travel Medicine. 2021;28(7):1-3'},{id:"B87",body:'U.S. Food and Drug Administration, FDA Revokes Emergency Use Authorization for Monoclonal Antibody Bamlanivimab. U.S. FDA: Silver Spring, MD,U.S.; 2021'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ricardo Izurieta",address:"ricardoi@usf.edu",affiliation:'
College of Public Health, University of South Florida, Tampa, Florida, United States
College of Public Health, University of South Florida, Tampa, Florida, United States
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Although the wet process using acid is in practical use in the in-plant recycle of sludge, higher selectivity between rare earths and Fe at room temperature is desired. We have recently proposed a pretreatment of corrosion before the hydrochloric acid (HCl) leaching and the oxalic acid precipitation. Almost full recovery of rare earths can be achieved even at room temperature process. In practical extraction methods, employing wet processes, the discharge of waste acid solution is a problem that needs to be solved to reduce the environmental impact. We further present an encouraging demonstration of rare earth extraction from NdFeB magnet using a closed-loop HCl-based process. Triple extraction has been conducted, and the recovery ratio of rare earths is approximately 50% in each extraction, which is reduced from almost 100% recovery in a one-shot extraction. Despite the reduced extraction efficiency, our method with a rather small number of procedures at almost room temperature is still highly advantageous in terms of cost and environmental friendliness. 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If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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IMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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Lubarsky, D. Shcherbik, O. Bibik, Y. Gopala and B. T. Zinn",authors:[{id:"65353",title:"Dr.",name:"Eugene",middleName:null,surname:"Lubarsky",slug:"eugene-lubarsky",fullName:"Eugene Lubarsky"}]},{id:"57228",doi:"10.5772/intechopen.71002",title:"Thresholding Algorithm Optimization for Change Detection to Satellite Imagery",slug:"thresholding-algorithm-optimization-for-change-detection-to-satellite-imagery",totalDownloads:1631,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"To detect changes in satellite imagery, a supervised change detection technique was applied to Landsat images from an area in the south of México. At first, the linear regression (LR) method using the first principal component (1-PC) data, the Chi-square transformation (CST) method using first three principal component (PC-3), and tasseled cap (TC) images were applied to obtain the continuous images of change. Then, the threshold was defined by statistical parameters, and histogram secant techniques to categorize as change or unchanged the pixels. A threshold optimization iterative algorithm is proposed, based on the ground truth data and assessing the accuracy of a range of threshold values through the corresponding Kappa coefficient of concordance. Finally, to evaluate the change detection accuracy of conventional methods and the threshold optimization algorithm, 90 polygons (15,543 pixels) were sampled, categorized as real change/unchanged zones, and defined as ground truth, from the interpretation of color aerial photo slides aided by the land cover maps to obtain the omission/commission errors and the Kappa coefficient of agreement. The results show that the threshold optimization is a suitable approach that can be applied for change detection analysis.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"René Vázquez-Jiménez, Rocío N. Ramos-Bernal, Raúl Romero-\nCalcerrada, Patricia Arrogante-Funes, Sulpicio Sanchez Tizapa and\nCarlos J. Novillo",authors:[{id:"213505",title:"Dr.",name:"René",middleName:null,surname:"Vázquez-Jiménez",slug:"rene-vazquez-jimenez",fullName:"René Vázquez-Jiménez"},{id:"213527",title:"Dr.",name:"Raúl",middleName:null,surname:"Romero-Calcerrada",slug:"raul-romero-calcerrada",fullName:"Raúl Romero-Calcerrada"},{id:"213529",title:"Dr.",name:"Rocío N.",middleName:null,surname:"Ramos-Bernal",slug:"rocio-n.-ramos-bernal",fullName:"Rocío N. Ramos-Bernal"},{id:"213530",title:"MSc.",name:"Patricia",middleName:null,surname:"Arrogante-Funes",slug:"patricia-arrogante-funes",fullName:"Patricia Arrogante-Funes"},{id:"213531",title:"Dr.",name:"Carlos J.",middleName:null,surname:"Novillo",slug:"carlos-j.-novillo",fullName:"Carlos J. Novillo"},{id:"221412",title:"Dr.",name:"Sulpicio",middleName:null,surname:"Sánchez-Tizapa",slug:"sulpicio-sanchez-tizapa",fullName:"Sulpicio Sánchez-Tizapa"}]},{id:"53153",doi:"10.5772/66343",title:"Fractal Light Vortices",slug:"fractal-light-vortices",totalDownloads:1788,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Vortex lenses produce special wavefronts with zero-axial intensity, and helical phase structure. The variations of the phase and amplitude of the vortex produce a circular flow of energy that allows transmitting orbital angular momentum. This property is especially in optical trapping, because due to the orbital angular momentum of light, they have the ability to set the trapped particles into rotation. Vortex lenses engraved in diffractive optical elements have been proposed in the last few years. These lenses can be described mathematically as a two-dimensional (2D) function, which expressed in polar coordinates are the product of two different separable one-dimensional (1D) functions: One, depends only on the square of radial coordinate, and the other one depends linearly on the azimuthal coordinate and includes the topological charge. The 1D function that depends on the radial coordinate is known as a zone plate. Here, vortex lenses, constructed using different aperiodic zone plates, are reviewed. Their optical properties are studied numerically by computing the intensity distribution along the optical axis and the transverse diffraction patterns along the propagation direction. It is shown that these elements are able to create a chain of optical traps with a tunable separation, strength and transverse section.",book:{id:"5370",slug:"vortex-dynamics-and-optical-vortices",title:"Vortex Dynamics and Optical Vortices",fullTitle:"Vortex Dynamics and Optical Vortices"},signatures:"Federico J. Machado, Juan A. Monsoriu and Walter D. Furlan",authors:[{id:"186344",title:"Prof.",name:"Walter",middleName:null,surname:"Furlan",slug:"walter-furlan",fullName:"Walter Furlan"}]},{id:"58322",doi:"10.5772/intechopen.72603",title:"Image Segmentation Based on Mathematical Morphological Operator",slug:"image-segmentation-based-on-mathematical-morphological-operator",totalDownloads:1555,totalCrossrefCites:2,totalDimensionsCites:7,abstract:"Image segmentation is the process of partitioning a digital image into multiple regions (sets of pixels); the pixels in each region have similar attributes. It is often used to separate an image into regions in terms of surfaces, objects, and scenes, especially for object location and boundary extraction. Until now, many general-purpose algorithms and techniques have been proposed for image segmentation. Typical and traditional methods are: (1) threshold-based method; (2) edge-based method; and (3) region-based method. In this chapter, we propose an approach of image segmentation based on mathematical morphology operator: toggle operator. The experimental result shows that the proposed method can segment natural scene images into homogeneous regions effectively.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"Jianjun Chen, Haijian Shao and Chunlong Hu",authors:[{id:"212306",title:"Ph.D.",name:"Jianjun",middleName:null,surname:"Chen",slug:"jianjun-chen",fullName:"Jianjun Chen"}]},{id:"53041",doi:"10.5772/66323",title:"Partially Coherent Vortex Beam: From Theory to Experiment",slug:"partially-coherent-vortex-beam-from-theory-to-experiment",totalDownloads:2046,totalCrossrefCites:4,totalDimensionsCites:6,abstract:"Partially coherent vortex beam exhibits some unique and interesting properties, for example, correlation singularities (i.e., ring dislocations) exist in its correlation function, and one can determine the magnitude of the topological charge of the vortex phase from the number of the ring dislocations. Modulating the coherence of a vortex beam provides a convenient way for shaping its focused beam spot, which is useful for material processing and optical trapping. Furthermore, a partially coherent vortex beam has an advantage over a partially coherent beam without vortex phase for reducing turbulence‐induced scintillation, which will be useful in free‐space optical communications. We introduce recent theoretical and experimental developments on partially coherent vortex beams.",book:{id:"5370",slug:"vortex-dynamics-and-optical-vortices",title:"Vortex Dynamics and Optical Vortices",fullTitle:"Vortex Dynamics and Optical Vortices"},signatures:"Xianlong Liu, Lin Liu, Yahong Chen and Yangjian Cai",authors:[{id:"186341",title:"Prof.",name:"Yangjian",middleName:null,surname:"Cai",slug:"yangjian-cai",fullName:"Yangjian Cai"},{id:"194234",title:"Dr.",name:"Xianlong",middleName:null,surname:"Liu",slug:"xianlong-liu",fullName:"Xianlong Liu"},{id:"194235",title:"Dr.",name:"Lin",middleName:null,surname:"Liu",slug:"lin-liu",fullName:"Lin Liu"},{id:"194236",title:"Dr.",name:"Yahong",middleName:null,surname:"Chen",slug:"yahong-chen",fullName:"Yahong Chen"}]}],mostDownloadedChaptersLast30Days:[{id:"53106",title:"Dynamical Particle Motions in Vortex Flows",slug:"dynamical-particle-motions-in-vortex-flows",totalDownloads:2264,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Circular vortex flows generate interesting self-organizing phenomena of particle motions, that is, particle clustering and classification phenomena. These phenomena result from interaction between vortex dynamics and relaxation of particle velocity due to drag. This chapter introduces particle clustering in stirred vessels and particle classification in Taylor vortex flow based on our previous research works. The first part of this chapter demonstrates and explains a third category of solid-liquid separation physics whereby particles spontaneously localize or cluster into small regions of fluids by taking the clustering phenomena in stirred vessels as an example. The second part of this chapter discusses particle classification phenomena due to shear-induced migration. Finally, this chapter discusses about process intensification utilizing these self-organizing phenomena of particle motions in vortex flows.",book:{id:"5370",slug:"vortex-dynamics-and-optical-vortices",title:"Vortex Dynamics and Optical Vortices",fullTitle:"Vortex Dynamics and Optical Vortices"},signatures:"Steven Wang and Naoto Ohmura",authors:[{id:"186403",title:"Prof.",name:"Naoto",middleName:null,surname:"Ohmura",slug:"naoto-ohmura",fullName:"Naoto Ohmura"},{id:"187311",title:"Dr.",name:"Steven",middleName:null,surname:"Wang",slug:"steven-wang",fullName:"Steven Wang"}]},{id:"53651",title:"Vortex Spinning System and Vortex Yarn Structure",slug:"vortex-spinning-system-and-vortex-yarn-structure",totalDownloads:5009,totalCrossrefCites:1,totalDimensionsCites:5,abstract:"Studying the yarn formation with the swirling air concept arouse of interest of the researchers for a long time because it appears to be easy to understand as a spinning principle. These kinds of systems are known as the vortex yarn spinning systems. The air-jet spinning methods have been developed since it is possible to eliminate the movable elements as the spindle and the traveler in ring spinning or the centrifuge in rotor spinning. The success of Murata vortex spinning (MVS) system which is the newest system after all studies of air-jet systems has been much acceptable especially for the spinning ability of 100% cotton in high speeds (500 m/min) and the yarn structure resembling ring yarn structure rather than rotor yarns. This study summarizes the historical background of vortex spinning, the spinning principle and the structure of the yarn spun on this system, as well as the factors influencing the yarn quality and finally the developments in vortex spinning technology.",book:{id:"6028",slug:"vortex-structures-in-fluid-dynamic-problems",title:"Vortex Structures in Fluid Dynamic Problems",fullTitle:"Vortex Structures in Fluid Dynamic Problems"},signatures:"Gizem Karakan Günaydin and Ali Serkan Soydan",authors:[{id:"186277",title:"Dr.",name:"Gizem",middleName:null,surname:"Karakan Günaydin",slug:"gizem-karakan-gunaydin",fullName:"Gizem Karakan Günaydin"},{id:"186607",title:"Dr.",name:"Ali",middleName:null,surname:"Serkan Soydan",slug:"ali-serkan-soydan",fullName:"Ali Serkan Soydan"}]},{id:"57228",title:"Thresholding Algorithm Optimization for Change Detection to Satellite Imagery",slug:"thresholding-algorithm-optimization-for-change-detection-to-satellite-imagery",totalDownloads:1631,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"To detect changes in satellite imagery, a supervised change detection technique was applied to Landsat images from an area in the south of México. At first, the linear regression (LR) method using the first principal component (1-PC) data, the Chi-square transformation (CST) method using first three principal component (PC-3), and tasseled cap (TC) images were applied to obtain the continuous images of change. Then, the threshold was defined by statistical parameters, and histogram secant techniques to categorize as change or unchanged the pixels. A threshold optimization iterative algorithm is proposed, based on the ground truth data and assessing the accuracy of a range of threshold values through the corresponding Kappa coefficient of concordance. Finally, to evaluate the change detection accuracy of conventional methods and the threshold optimization algorithm, 90 polygons (15,543 pixels) were sampled, categorized as real change/unchanged zones, and defined as ground truth, from the interpretation of color aerial photo slides aided by the land cover maps to obtain the omission/commission errors and the Kappa coefficient of agreement. The results show that the threshold optimization is a suitable approach that can be applied for change detection analysis.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"René Vázquez-Jiménez, Rocío N. Ramos-Bernal, Raúl Romero-\nCalcerrada, Patricia Arrogante-Funes, Sulpicio Sanchez Tizapa and\nCarlos J. Novillo",authors:[{id:"213505",title:"Dr.",name:"René",middleName:null,surname:"Vázquez-Jiménez",slug:"rene-vazquez-jimenez",fullName:"René Vázquez-Jiménez"},{id:"213527",title:"Dr.",name:"Raúl",middleName:null,surname:"Romero-Calcerrada",slug:"raul-romero-calcerrada",fullName:"Raúl Romero-Calcerrada"},{id:"213529",title:"Dr.",name:"Rocío N.",middleName:null,surname:"Ramos-Bernal",slug:"rocio-n.-ramos-bernal",fullName:"Rocío N. Ramos-Bernal"},{id:"213530",title:"MSc.",name:"Patricia",middleName:null,surname:"Arrogante-Funes",slug:"patricia-arrogante-funes",fullName:"Patricia Arrogante-Funes"},{id:"213531",title:"Dr.",name:"Carlos J.",middleName:null,surname:"Novillo",slug:"carlos-j.-novillo",fullName:"Carlos J. Novillo"},{id:"221412",title:"Dr.",name:"Sulpicio",middleName:null,surname:"Sánchez-Tizapa",slug:"sulpicio-sanchez-tizapa",fullName:"Sulpicio Sánchez-Tizapa"}]},{id:"57575",title:"Colorimetry and Dichromatic Vision",slug:"colorimetry-and-dichromatic-vision",totalDownloads:1739,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Normal trichromats have three types of cone photoreceptors: L, M, and S cones (most sensitive to long, medium, or short wavelengths, respectively). Therefore, standard colorimetry is based on three variables (X, Y, Z). Dichromats only have two types of functional cones due to genetic factors. The main consequences are that dichromats (1) confuse colors that can only be discriminated by the response of the type of cone they lack and (2) make errors when naming colors. Chromaticity diagrams can be used to specify dichromats’ color confusions. Confusion points represent imaginary stimuli that only activate L, M, or S cones. Confusion lines radiate from confusion points and represent pseudoisochromatic stimuli (i.e., colors confused by the corresponding type of dichromat if presented at an appropriate intensity). Dichromat’s color appearance models have been developed to simulate the colors supposedly seen by dichromats, and there exist color simulation tools that implement some of those models.",book:{id:"6126",slug:"colorimetry-and-image-processing",title:"Colorimetry and Image Processing",fullTitle:"Colorimetry and Image Processing"},signatures:"Humberto Moreira, Leticia Álvaro, Anna Melnikova and Julio Lillo",authors:[{id:"208770",title:"Dr.",name:"Humberto",middleName:null,surname:"Moreira Villegas",slug:"humberto-moreira-villegas",fullName:"Humberto Moreira Villegas"},{id:"208826",title:"Dr.",name:"Leticia",middleName:null,surname:"Álvaro",slug:"leticia-alvaro",fullName:"Leticia Álvaro"},{id:"208827",title:"BSc.",name:"Anna",middleName:null,surname:"Melnikova",slug:"anna-melnikova",fullName:"Anna Melnikova"},{id:"208828",title:"Prof.",name:"Julio",middleName:null,surname:"Lillo",slug:"julio-lillo",fullName:"Julio Lillo"}]},{id:"31571",title:"Fluid Dynamics of Gas - Solid Fluidized Beds",slug:"fluid-dynamics-of-gas-solid-fluidized-beds",totalDownloads:10130,totalCrossrefCites:1,totalDimensionsCites:3,abstract:null,book:{id:"1013",slug:"advanced-fluid-dynamics",title:"Advanced Fluid Dynamics",fullTitle:"Advanced Fluid Dynamics"},signatures:"Germán González Silva, Natalia Prieto Jiménez and Oscar Fabio Salazar",authors:[{id:"64562",title:"Dr.",name:"German",middleName:null,surname:"Gonzalez Silva",slug:"german-gonzalez-silva",fullName:"German Gonzalez Silva"},{id:"64572",title:"MSc.",name:"Natalia",middleName:null,surname:"Prieto Jimenez",slug:"natalia-prieto-jimenez",fullName:"Natalia Prieto Jimenez"},{id:"80971",title:"MSc.",name:"Oscar Fabio",middleName:null,surname:"Salazar",slug:"oscar-fabio-salazar",fullName:"Oscar Fabio Salazar"}]}],onlineFirstChaptersFilter:{topicId:"1217",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:16,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:4,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"
\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
",coverUrl:"https://cdn.intechopen.com/series/covers/25.jpg",latestPublicationDate:"June 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"197485",title:"Dr.",name:"J. Kevin",middleName:null,surname:"Summers",slug:"j.-kevin-summers",fullName:"J. Kevin Summers",profilePictureURL:"https://mts.intechopen.com/storage/users/197485/images/system/197485.jpg",biography:"J. Kevin Summers is a Senior Research Ecologist at the Environmental Protection Agency’s (EPA) Gulf Ecosystem Measurement and Modeling Division. He is currently working with colleagues in the Sustainable and Healthy Communities Program to develop an index of community resilience to natural hazards, an index of human well-being that can be linked to changes in the ecosystem, social and economic services, and a community sustainability tool for communities with populations under 40,000. He leads research efforts for indicator and indices development. Dr. Summers is a systems ecologist and began his career at the EPA in 1989 and has worked in various programs and capacities. This includes leading the National Coastal Assessment in collaboration with the Office of Water which culminated in the award-winning National Coastal Condition Report series (four volumes between 2001 and 2012), and which integrates water quality, sediment quality, habitat, and biological data to assess the ecosystem condition of the United States estuaries. He was acting National Program Director for Ecology for the EPA between 2004 and 2006. He has authored approximately 150 peer-reviewed journal articles, book chapters, and reports and has received many awards for technical accomplishments from the EPA and from outside of the agency. Dr. Summers holds a BA in Zoology and Psychology, an MA in Ecology, and Ph.D. in Systems Ecology/Biology.",institutionString:null,institution:{name:"Environmental Protection Agency",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"302145",title:"Dr.",name:"Felix",middleName:null,surname:"Bongomin",slug:"felix-bongomin",fullName:"Felix Bongomin",profilePictureURL:"https://mts.intechopen.com/storage/users/302145/images/system/302145.jpg",institutionString:null,institution:{name:"Gulu University",institutionURL:null,country:{name:"Uganda"}}},{id:"45803",title:"Ph.D.",name:"Payam",middleName:null,surname:"Behzadi",slug:"payam-behzadi",fullName:"Payam Behzadi",profilePictureURL:"https://mts.intechopen.com/storage/users/45803/images/system/45803.jpg",institutionString:"Islamic Azad University, Tehran",institution:{name:"Islamic Azad University, Tehran",institutionURL:null,country:{name:"Iran"}}}]},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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