Critical success factors for implementing KM strategies in the KSA public sector organisations.
\r\n\tWithin this scenario, special attention needs to be devoted to financial implications, due to their pervasiveness. Nobody would question the key role that finance plays to complement the real sphere of the economy and that has increasingly attracted both academics and practitioners. As a result, traditional pillars – such as financial markets, products, and institutions – have evolved significantly, with financial innovation fueling further progress over time. The global side of the coin features – among others – financially connected markets, international financial exchanges, and financial conglomerates that provide valuable opportunities in terms of international corporate finance. On the other side, recent advances have involved a wider recourse to ESG factors, allowed forward steps towards a more inclusive financial system, and have made digital finance a must, rather than an option, even though much remains to be accomplished, for instance, to facilitate access to formal financial channels in many underdeveloped regions.
\r\n\r\n\t
\r\n\tThis book aims to examine emerging trends, new perspectives, and empirical applications that deal with globalization and sustainability. The goal is to provide a comprehensive overview of these important concepts as valuable support to successfully meet the challenges and take on the opportunities ahead. At the same time, drawing upon empirical evidence can contribute to bridging the gap between theory and practice, which also fits within the scope of this book.
Today, public sector organisations are also known as knowledge-based organisations and knowledge is as critical a resource to public sector organisations as it is to private sector firms [1]. Knowledge is one of the building blocks for an organisation’s success and acts as a survival strategy in this knowledge era [2]. Therefore, knowledge resource resides in employees’ minds and organisations must utilise this valuable resource for their competitive advantage [3].
Ragsdell et al. [4] noted that knowledge and know-how cannot simply and freely be flowed and shared among colleagues in organisations. Knowledge is the act of knowing or being aware or familiar by learning from experience or association. Knowledge has been defined as the factor that enhances an individual’s capabilities for taking effective actions [5]. The two dimensions of knowledge according to Nonaka and Takeuchi [6]. The explicit knowledge is organised and well-structured; hence, it is easily communicated. The second dimension is the tacit knowledge which is hard to be explained and interpreted. It is not easily communicated and is based on the individuals’ experience, emotions, values and the ideals which they espouse. Madhoushi and Sadati [7] state that KM is a planned and well-structured process that includes managing the construction, designing, disposal and transfer of explicit as well as tacit knowledge in order to gain competitive advantage and encourage innovative ideas.
Jashapara [8] highlights that knowledge is considered as a critical and important factor in organisations for competitiveness and economic growth underlying innovation. Wiig [9] argued that knowledge will be the key to success in the twenty-first century, due to knowledge generating a value for the organisation when it is employed. Egbu [10] noted that knowledge management is the interrelated cyclical and iterative processes by which knowledge is identified, captured, codified, stored and disseminated for the benefit of the organisation. Chase [11] noted that knowledge management is a discipline that some industries and people adopt in order to encourage people to share knowledge or any ideas with the purpose of creating value-added products and services. Alavi and Leidner [12], in their seminal work, concluded that KM involves distinct but interdependent processes of knowledge creation, knowledge storage and retrieval, knowledge transfer and knowledge application. Thus, KM is a natural solution for improving operations and enhancing citizen’s satisfaction. The management of both explicit and tacit knowledge is a crucial aspect of the public sector in developing their competencies.
Yahya [13] stated that, in the Middle East and North Africa region, over two-thirds of organisations are evaluating the need for KM, but less than a third have or are currently setting up a KM programme. Milner [14] suggests that the lack of enthusiasm to adopt KM in the public sector is directly linked to the required achievement of innovative and creative outcomes through the sharing of tacit knowledge, “knowledge rich open and creative operating cultures”. The Kingdom of Saudi Arabia (KSA) aims to reduce fiscal deficit by improving state efficiency, reducing costs as well as its state subsidies. Consequently, the KSA Government has announced an ambitious new strategy: Vision 2030 [15]. It is tending towards knowledge economy. Therefore, this chapter explores the critical success factors (CSFs) for effective implementation of KM strategies in the KSA public sector organisations. The KSA organisations have been implementing KM solutions, but they face several issues and challenges, such as organisational culture, technology barriers and weaknesses in leadership’s lack of learning activities [16].
Digman [17] defined CSFs as the areas where things must go right in order for the business to flourish. Critical success factors are defined as the handful of key areas where an organisation must perform well on a consistent basis so as to achieve its mission [18]. Alazmi and Zairi [19] noted that CSFs are aimed at creating a KM environment that provides organisations with some sustainable competitive advantage through the continued creation of knowledge, maintenance of current knowledge assets and creating an environment in which the KM function can survive and grow. In the context of the implementation of KM strategies, CSFs represent the essential ingredients without which a project stands little chance of success.
The aim of this study is to investigate the CSFs and to structure the relationship between these CSFs for effective implementation of KM strategies in the KSA public sector organisations en-route to organisational competitiveness. Therefore, the choice of research methodology is a crucial and difficult step in the research process.
To explore the in-depth understanding of the current study research problem, the research focuses on the perceptions of individuals relating to the CSFs for implementing KM strategies in the KSA public sector organisations. Therefore, to gain an understanding of employees’ perceptions, it is necessary to use a methodology that elicits interviewees’ inner thoughts and feelings. Kvale [20] stated that an interview’s purpose is to gather descriptions of the lifeworld of the interviewee with respect to interpretation of the meaning of the described phenomena. Ribbens and Edwards [21] noted that the suitable number of experts for qualitative research may range from five to 50. Murry and Hammons [22] suggested that, for the qualitative decision-making process, the number of experts may be in the range of 10–30. To ensure greater dependability and transferability [23], a total of 42 professionals were interviewed in the KSA public sector organisations.
The sampling method used is purposive or non-probability sampling, whereby the subjective judgements of the researcher are used in selecting the sample [24]. In purposive sampling, participants are selected to meet a specific set of criteria. The study sample included directors, advisers and managers responsible for implementation of KM strategies in their respective departments/organisations.
An important sample size issue in qualitative research involves saturation of information [25]. Saturation is a term used to describe the point when no new insights or range of ideas are generated through adding more data. In this study, data were collected until no new aspects of the CSFs were revealed. In this study, actual saturation of data occurred before the 40th interview. Therefore, 42 interviews were conducted. Content analysis was used followed by interpretive structural modelling (ISM) method.
According to Watson [26], ISM is a method involving a qualitative and interpretive approach (based on the judgement of the experts from the industry and academia) to resolve complex problems based on a structural mapping of interconnections of attributes, followed by transforming them into a multi-level structural model. The finding from content analysis was subjected to ISM method.
According to Raj et al. [27], ISM has several characteristics which make it suitable to be applied in the present study: experts’ knowledge and experience is utilised to analyse the complex system and break it into different elements to build a clearer model; it is a modelling technique wherein relationships are depicted into a diagraph model; it is intended to be used for group and individual learning; and it improves the quality of communication within the context of the problem. Although ISM has several advantages, the methodology possesses a few limitations: a limited number of variables are used in the model development, leading, thus, to ignoring the least affecting variables or issues; and people’s bias, which may impact the final result.
Malone [28] noted that ISM is an application of simple notations of graph theory used to explain the complex pattern of relationships. This methodology is widely used by researchers for exploring the direct and indirect association among the identified parameters of various disciplines in a simplified way. ISM is utilised to understand the relationships between the CSFs and to develop insights into a collective understanding of these relationships.
The eight steps involved in the ISM method are listed below [29, 30, 31, 32].
In this study, interviewees were asked to list and describe the CSFs for implementing KM strategies in their organisation through face-to-face interviews. Table 1 shows the nine CSFs for implementing KM strategies in the KSA public sector organisations. Each of these CSFs is discussed in detail below.
CSFs for effective implementation of KM strategies | Percentage of interviewees cited (N = 42) |
---|---|
Leadership | 95% (40/42) |
Organisational culture | 90% (38/42) |
Information and communication technology infrastructure | 83% (35/42) |
Reward and incentive system | 81% (34/42) |
KM strategy | 76% (32/42) |
Knowledge audit | 71% (30/42) |
Training and education | 69% (29/42) |
Knowledge sharing | 60% (25/42) |
Knowledge capture | 48% (20/42) |
Critical success factors for implementing KM strategies in the KSA public sector organisations.
Organisation leadership forms the foundation for successful KM implementation [33]. Ichijo and Nonaka [34] emphasise the role of leadership in building and managing knowledge in organisations. By reviewing the literature to provide a framework for assessing KM and KM success factors, Jennex and Olfman [35] note that leadership is one of the most important critical success factors.
In this study, overwhelmingly 95% (40 of the 42) said that the absence of active management involvement is likely to mean that the KM process will be handicapped by insufficient time, finance and human resources. Therefore, it is most important that knowledge workers perceive their leaders as being actively engaged and committed to supporting knowledge activities and they recognise and reward such attempts in their co-workers. Leadership is most important because this is the authority that shapes the organisation; they can build, create, gain and implement knowledge to achieve organisational goals. If the leaders focus on the knowledge sharing and implementation, the subordinates cannot hoard knowledge. Moreover, the leaders may include KM in the organisation’s mission and vision.
For instance, one of the interviewees noted that:
The aforementioned statement suggests that organisations are creating new leadership positions at the organisation or department levels to create culture for knowledge capture and sharing. Yu et al. [36] pointed out that both the support from high-ranking officers and the activities arranged by KM groups would influence the KM performance positively. Putting transformation and change in perspective helps people balance the fears and opportunities associated with change, and to make better choices about the way that they react. Leadership is everyone’s job in an organisation, rather than the job of the leader, and it is hard to envision any degree of sustainability without it. Leadership is the essential ingredient in creating enthusiasm in an organisation, especially when the going gets tough. However, this factor is no different from that required in any other corporation driven by a strong vision [37].
In summary, leadership commitment to KM initiatives would assist in breaking down barriers in achieving KM goals—barriers such as tunnel vision, past practice, old ideas and cultural frameworks that, together, combine to discourage new visions of the future. The key to effective implementation of KM strategies in the KSA public sector organisations is for leadership to establish a culture that is proactive in formulating KM-related objectives, to pursue a strategy of continuous improvement and resource that strategy. In addition, leadership is about preparing organisations with a knowledge-based vision and values that resonate with the leadership team, all employees and key stakeholders. More importantly, top management and senior executives must demonstrate the sharing of their own knowledge, using others’ knowledge in the actions they take and giving credit to accountants who share their knowledge [38]. Therefore, leadership is crucial for implementing KM initiatives. Leadership skills need to be reinforced by the corporate values, the funding of corporate change programmes and willingness to transform organisations towards a knowledge-based view of the firm.
Of the interviewees, 90% (38 of the 42) asserted that organisational culture is one of the main critical success factors for successful implementation of KM-related initiatives in their organisations. These findings have also been supported by Al-Adaileh and Al-Atawi [58] as, in their study on the topic of significance of organisational culture in the context of Saudi Telecom; they concluded a positive direct relationship of organisational culture in the KM. The absence of active management involvement is likely to mean that the KM process will be handicapped by insufficient time, finance and human resources. Change in culture and individual behaviour must aim towards encouraging the use of knowledge, not for individual advantage, but for the benefits of the organisation as a whole [38].
Drawing on Tseng [39], organisational culture can either enable or disable the knowledge conversion process in an organisation. Liebowitz and Chen [40], for instance, found that it is more difficult to share knowledge in public sector organisations because most people associate knowledge with power, and their promotion opportunities. Tseng’s [39] proposition is based on her study to identify the extent of correlation between different types of organisational culture and knowledge conversion and corporate performance.
Schein [41] defined organisational culture as a set of implied principles held by the people in a society which determines the behavioural implications. In the nutshell, cultures are the product of the tacit underlying beliefs and values that enforce the actions needed to achieve organisational goals [42]. Wang et al. [43], in their study, also supported the idea that organisational culture determines the observable norms and practices that prevail in an organisation which then results in laying down the foundation for rituals, expectations, routines, stories and myths. On the other hand, the norms set by the culture lead to the promotion of social context for the communication between people. Hislop [44] hinted at a link between organisational culture and KM through arguing that organisational culture lays down the social context which, in return, determines the source of knowledge in an organisation, such as who holds the knowledge and who is to share the knowledge.
In this study, 83% (35 of the 42) of the interviewees noted that the effective implementation of information and communication technology (ICT) tools to facilitate knowledge capture, mapping and sharing is another important critical success factor for their organisations. An ICT infrastructure provides a broad platform for mapping knowledge, exchanging knowledge, coordinating activities, sharing knowledge and supporting globalisation of commerce. Certain technologies can go a long way in making knowledge exchange easier and more efficient.
Quintas [45] stated that ICT has an unquestionable place in organisations. Information and communication technologies must work with, and not against, the key fundamentals that make human beings knowledgeable in social contexts. This emphasises the need for the transformation from tacit to explicit knowledge. Some of the advantages of ICTs are that they can lead to effective and efficient practices through the use and exploitation of knowledge and reduction in the number of mistakes being made.
The role of a rewards and incentive system in managing knowledge is to motivate employees to map, capture and share their tacit and explicit knowledge. It is found that the motivation to contribute knowledge is an intangible critical success factor for any KM activity [46]. In this study, 81% (32 of the 42) of the interviewees stated that a rewards and incentive system to promote KM initiatives is another important critical success factor. Wang et al. [43] also supported the adverse role of monetary reward for the KM, arguing that monetary rewards promote transactional behaviour in an organisation that, in the long-term, demotivates staff and could even lead to the destruction of a firm’s financial position.
Knowledge workers are knowledge providers and value creators in an organisation [47]. As such, organisations will not be able to turn ‘our people’ into ‘our most valuable assets’ without addressing the real need of ‘our people’. Therefore, it is important to encourage, motivate and reward employees who contribute to the organisation’s knowledge and this culture-related issue remains a challenging task for most organisations [48]. However, relying solely on the monetary reward or incentive system to promote KM could prove to be a problematic task, hence, it is important for the management to keep a balance between monetary and non-monetary reward as a basis for the promotion of KM [49].
In this study, 76% (32 of 42) of the interviewees noted the need for having a robust KM strategy as one of the most important critical success factors. Many public sector organisations in the KSA suffer from the absence of a KM strategy and even those who do have one usually end up in facing resistance from upper level management to implement it [50]. In recent years, the concept of strategic management has shifted from the resource-based view to the knowledge-based view of the firm, as it enables organisations to increase their capacity and competitive advantage [51]. While the basic strategy of an organisation defines corporate direction through setting up its goals, objectives and strategic policies, when it comes to the KM, strategy becomes the logical architecture that specifies critical elements in an organisation’s strategy and serves as a tool for communicating and clarifying that strategy. Despite of the importance of the KM strategy for providing firms with competitive advantage in the marketplace, public sector organisations tend to have a lack in their ability to lay down a robust KM strategy. For instance, while studying the challenges faced by the public sector organisations for promoting open innovation, Mergel and Dsouza [52] found that even western public sector organisation’s lack in their ability to promote innovation and the core reasons behind such inability is the lack of a robust KM strategy.
In this study, 71% (30 out of 42) of the interviewees also asserted that knowledge audit is an important tool for implementing and monitoring KM practices in the public sector organisations in Saudi Arabia. Alzeban and Sawan [53], in their study on the internal audit among public sector organisations in the Saudi Arabia, concluded a lack of focus of internal audit on the KM with focus instead given to more materialistic factors, such as financial issues and service quality. Generally, an audit is described as a process that investigates whether or not the goals of an organisation are met [54]. In the light of constant changes in the way organisations are run in the modern world, a knowledge audit has become a necessary part since it assists in identifying the extent of the efficiency by which one system has been replaced by another through comparing the resources consumed during the process and the new system, hence, helping in justifying the adoption of the new system. Similarly, while studying the process of knowledge audit in the implementation of KM in the public sector organisations in Malaysia, Zulkifli et al. [55] signified the importance of KM audit in public sector organisations through arguing that the work of public sector organisations involves both tacit and explicit knowledge; however, they insisted that there tends to be more tacit knowledge involved in the daily work of public sector organisations than explicit ones, due to the involvement of a hierarchical management structure.
Furthermore, hierarchical management structure has been found to negatively impact the process of knowledge capturing and the knowledge sharing process, hence, this further necessitates the conduct of a knowledge audit in the public sector firms [55]. While investigating the auditing concept within the information management field, Yatin et al. [54] provided a knowledge spectrum that emphasises on conducting a knowledge audit on the basis of four areas: wisdom, knowledge, information and data. By wisdom, Yatin et al. [54] meant wisdom of individuals over the overall purpose of the organisation. On the other hand, Yatin et al. [54] distinguished between data and information from knowledge by arguing that, while establishment of knowledge requires an extensive amount of experience with information on a subject, ultimately, information and data merely assist in the creation of knowledge and wisdom is usually reached after acquiring sufficient knowledge about the subject matter. Therefore, it would not be wrong to argue that a knowledge audit covers all other three elements of the knowledge spectrum, such a data audit, wisdom audit and information audit, and, hence, plays an important role in leveraging the knowledge in an organisation.
In this study, 69% (29 out of 42) interviewees noted that training and education is an important critical success factor for effective implementation of KM strategies. Drawing on the study by Abd-Rahman et al. [56], training and education cannot provide any material benefit to the organisation unless knowledge gained through training and education is shared, applied and documented for the purpose of organisational-wide use. To this end, Abd-Rahman et al. [56], in their study, concluded that it is important for the employees to apply and protect newly gained knowledge in the organisation so that improved organisational-wide results are achieved. However, while studying the main barriers to KM in the Saudi organisations, Al-Hussain et al. [50] found that the process used for training and educating employees is weak, as it is influenced by the cultural characteristics of collectivism. Collectivism has been defined as the cultural characteristics under which people tend to give preference to people to whom they know and has been recognised as a killer for merit. Therefore, Al-Hussain et al. [50] argued that, thanks to collectivism, a ‘wastav’ (bribing and connection) system prevails in the Saudi public sector organisations which, in turn, leads to the distribution of learning and development opportunities among those employees who are close to the management and, hence, directly impacts the KM process.
In this study, 60% (25 out of 42) of the interviewees noted that sharing knowledge is the most impactful critical success factor for effective implementation of KM strategies. Among the many processes of the KM cycle, knowledge sharing has been identified as the most significant process as well as the cornerstone for effective KM [57]. Knowledge sharing has been associated with numerous positive outcomes in the past, such as organisational effectiveness, organisational innovation capability, improved productivity and team task performance. In their study on knowledge sharing, Wang and Wang [43] identified a direct relationship between knowledge sharing and organisational level innovation and performance. However, when it comes to the Saudi public sector organisations, such as Saudi Telecom Company (STC), Al-Adaileh and Al-Atawi [58] found cultural implications that prohibit the process required for the exchange of knowledge among employees in the organisation. This is despite the fact that effective KM cannot be attained unless knowledge is exchanged, distributed and shared among members of the organisation [59].
In relation to public service, knowledge sharing is able to improve the quality of a public service delivery system and enhance the productivity level of public service employees [57]. However, there is further need to identify whether the practice has been used effectively by the management or not.
In this study, only 48% (20 out of 42) interviewees noted that capturing knowledge is a key success factor for implementing KM strategies. Capturing tacit knowledge is the process through which the experience and expertise of an individual in an organisation is collected and made available to anyone who needs it [60]. Undoubtedly, capturing knowledge may be difficult, particularly in the case of tacit knowledge, but knowledge often only remains tacit until someone asks an appropriate question. At that point, tacit knowledge can become explicit, but, unless that knowledge is captured for someone else to use it again at a later date, learning, productivity and innovation are stifled. Knowledge work already represents 40% of the global economy. Unfortunately, over 50% of organisational knowledge is tacit and non-formalised. It is resident in the minds of its workers. Hence, the capture of knowledge is vital for any organisation, especially for key decisions made based on experience, which is usually shared informally.
Alamri and Abuaghayed [61] concluded that, while management in the Saudi organisations does recognise the importance of capturing knowledge for an effective KM, due to the problems at the structural level, such as public sector firms usually being run under a close rational and tightly controlled institutional mechanism, this results in the prohibition of the knowledge capturing practice.
In the present study, ISM method coupled with MICMAC (Matrix of Cross-Impact Multiplications Applied to Classification) is applied to form the interrelationships between the identified critical factors for knowledge management and establish their driving and dependence power.
The interviews were analysed closely to identify any existing pair-wise relationships. The Structural Self-Interaction Matrix (SSIM) is formulated based on the interrelationship between the nine CSFs identified, as shown in Table 2. Four symbols were used to define the direction of the relationship between the CSFs.
V | CSF i will help achieve CSF j |
A | CSF j will help achieve CSF i |
X | CSF i and j will help achieve each other |
O | No relation between CSF i and j |
Sl. no | Critical success factors | CSF1 | CSF2 | CSF3 | CSF4 | CSF5 | CSF6 | CSF7 | CSF8 | CSF9 |
---|---|---|---|---|---|---|---|---|---|---|
CSF1 | Leadership | — | X | V | V | V | O | V | V | V |
CSF2 | Organisational culture | — | — | O | V | V | O | V | V | V |
CSF3 | Information and communication technology infrastructure | — | — | — | O | X | V | V | V | V |
CSF4 | Reward and incentive system | — | — | — | — | A | O | V | V | V |
CSF5 | KM strategy | — | — | — | — | — | V | V | V | V |
CSF6 | Knowledge audit | — | X | V | V | |||||
CSF7 | Training and education | — | X | X | ||||||
CSF8 | Knowledge sharing | X | ||||||||
CSF9 | Knowledge capture |
Structural self-interaction matrix (SSIM) of the critical success factors for implementing KM strategies in the KSA public sector organisations.
The initial reachability matrix (binary matrix) shown in Table 3 is developed from the SSIM. The reachability matrix shown in Table 4 is obtained by manually adding the transitivity property to the initial reachability matrix. For instance, if a CSF i is related to j and j is related to n, then i is necessarily related to n.
Sl. no | Critical success factors | CSF1 | CSF2 | CSF3 | CSF4 | CSF5 | CSF6 | CSF7 | CSF8 | CSF9 |
---|---|---|---|---|---|---|---|---|---|---|
CSF1 | Leadership | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
CSF2 | Organisational culture | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
CSF3 | Information and communication technology infrastructure | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
CSF4 | Reward and incentive system | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
CSF5 | KM strategy | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
CSF6 | Knowledge audit | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
CSF7 | Training and education | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
CSF8 | Knowledge sharing | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
CSF9 | Knowledge capture | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Initial reachability matrix of the of the critical success factors for implementing KM strategies in the KSA public sector organisations.
Sl. no | Critical success factors | CSF1 | CSF2 | CSF3 | CSF4 | CSF5 | CSF6 | CSF7 | CSF8 | CSF9 | Driving power |
---|---|---|---|---|---|---|---|---|---|---|---|
CSF1 | Leadership | 1 | 1 | 1 | 1 | 1 | 1* | 1 | 1 | 1 | 9 |
CSF2 | Organisational culture | 1 | 1 | 1* | 1 | 1 | 1* | 1 | 1 | 1 | 9 |
CSF3 | Information and communication technology infrastructure | 0 | 0 | 1 | 1* | 1 | 1 | 1 | 1 | 1 | 7 |
CSF4 | Reward and incentive system | 0 | 0 | 0 | 1 | 0 | 1* | 1 | 1 | 1 | 5 |
CSF5 | KM strategy | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 7 |
CSF6 | Knowledge audit | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1* | 1* | 4 |
CSF7 | Training and education | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 4 |
CSF8 | Knowledge sharing | 0 | 0 | 0 | 0 | 0 | 1* | 1 | 1 | 1 | 4 |
CSF9 | Knowledge capture | 0 | 0 | 0 | 0 | 0 | 1* | 1 | 1 | 1 | 4 |
Dependence power | 2 | 2 | 4 | 5 | 4 | 9 | 9 | 9 | 9 | 53/53 |
Final reachability matrix of the of the critical success factors for implementing KM strategies in the KSA public sector organisations.
*Entries are adapted to incorporate the transitivity concept, to fill in the gap. The final reachability matrix is obtained after the incorporation of the transitivity
CSFs in which the reachability and the intersection sets are similar would be allocated the top level in the ISM hierarchy. CSFs at this level do not have any other CSFs above them. Once CSFs within the top-level are identified, they are separated from the rest of the CSFs. The same process is repeated to identify CSFs within the next levels, until all CSFs fall in each level. This level partition helps with diagraph modelling. Table 5 shows the reachability set, antecedent set, intersection set, and the initial and final levels of all the CSFs. The level evaluation process of all the nine CSFs is completed in four iterations.
Sl. no | Reachability set | Antecedent set | Intersection | Level |
---|---|---|---|---|
CSF1 | 1,2,3,4,5,6,7,8,9 | 1,2 | 1,2 | IV |
CSF2 | 1,2,3,4,5,6,7,8,9 | 1,2 | 1,2 | IV |
CSF3 | 3,4,5,6,7,8,9 | 1,2,3,5 | 3,5 | III |
CSF4 | 4,6,7,8,9 | 1,2,3,4,5 | 4 | II |
CSF5 | 3,4,5,6,7,8,9 | 1,2,3,5 | 3,5 | III |
CSF6 | 6,7,8,9 | 1,2,3,4,5,6,7,8,9 | 6,7,8,9 | I |
CSF7 | 6,7,8,9 | 1,2,3,4,5,6,7,8,9 | 6,7,8,9 | I |
CSF8 | 6,7,8,9 | 1,2,3,4,5,6,7,8,9 | 6,7,8,9 | I |
CSF9 | 6,7,8,9 | 1,2,3,4,5,6,7,8,9 | 6,7,8,9 | I |
Level partitions of the reachability matrix (iteration I to iteration IV).
A preliminary diagraph containing the transitive links shown in Figure 1 is obtained from the final reachability matrix. In the case of a relationship between CSF i and j, an arrow points from i to j. The final diagraph is developed after the removal of indirect links. The top-level CSFs are positioned at the top of the diagraph, followed by second level CSFs and so on.
Final diagraph showing the relationship between the CSFs.
The developed diagraph is converted into an ISM model by transforming the nodes by the CSFs’ statements, as shown in Figure 2. From Table 5, it can be seen that CSFs knowledge audit, training and education, knowledge sharing, and knowledge capture were found at level one. Therefore, these CSFs were positioned at the top-level of the ISM hierarchy. The rest of the CSFs have been positioned in the hierarchy, reflecting their levels, as presented in Figure 2. The arrow direction indicates the relationship between the different CSFs. For example, the relationship between the organisational culture and leadership was a two-way relationship. Therefore, an arrow pointing in both directions was used to denote this relationship, whereas the relationship between the leadership and KM strategy was only one direction, in which the leadership influences the KM strategy. Therefore, an arrow pointing from the leadership to the KM strategy was used. It can be observed from Figure 2 that leadership and organisational culture were significant CSFs for implementing KM strategies in the KSA public sector organisations, as they came at the base level of the ISM model.
ISM based model of CSFs.
Based on the driver power and dependence power generated inTable 4, the CSFs for implementing KM strategies in the KSA organisations were classified into four clusters (namely autonomous, dependent, linkage and driving factors) as shown in Figure 3, which are explained below.
The driving and dependence power diagram of CSFs.
Autonomous clusters are the CSFs with a weak driving as well as dependency power and are relatively disconnected from the system. These CSFs do not have much influence on the other CSFs of the system and are less significant to the policy and decision-makers. It is clear from Figure 3 that there no CSFs come under an autonomous cluster. The dependent cluster comprises of knowledge audit (CSF6), training and education (CSF7), knowledge sharing (CSF8), and knowledge capture (CSF9), having driving power value of 4 and high dependency power value of 9. In the cluster of linking factors, there is one CSF, namely reward and incentives system (CSF4), having dependency and driving power value of 5. In the driving factors cluster, there are four factors, namely leadership (CSF1) and organisational culture (CSF2), with the highest driving power of 9 and least dependency power value of 2. Two CSFs, namely information and communication technology infrastructure (CSF3) and KM strategy (CSF5), are found to have a driving power of 7 and dependency power of 4. The factors of this cluster are very significant for the decision and policy makers as these CSFs have very high influential power and less dependency on the other CSFs.
In the current study, the CSFs for implementing KM strategies within the KSA public sector organisations are identified and modelled. The study findings suggest that leadership and organisational culture are very important CSFs for successful implementation of KM strategies.
Scholars have proposed that public sector decision-makers face unique challenges, which includes declining resources, frequent political influences, demands from external sources and, generally, the requirements to accomplish more with fewer resources [62]. Hence, there is a significant need in the public sector to deliver better value for money in services with increasing pressure to deliver more with less, the public sector needs to introduce more innovative and effective solutions and reduce decision-making time and the level of bureaucracy.
KM offers a perspective, principles, methods, practices and tools that can help KSA public sector organisations become more like intelligent and adaptive organisations. KM methods, practices and tools support better decisions and actions by enabling people to integrate (identify, capture and share) relevant existing knowledge and to produce new knowledge. However, there is a vast amount of knowledge within KSA public sector organisations. In KM the role of leadership has become a key operational component in the public sector due to the ever-changing and increasing demands from the public for government employees to do more with less [63]. The leadership must ensure that there is continuous personal development and lifelong learning for employees associated with KM in order to attract the right calibre of employees with career aspirations in KM. Furthermore, the leadership must ensure that a reward and recognition system is in place that promotes a joint sense of ownership of the KM programme.
This chapter has empirically investigated CSFs for successful implementation of KM strategies in the KSA public sector organisations. Semi-structured interviews were conducted with 42 KM experts. By applying content analysis, the CSFs which emerged from the analysis were grouped into nine categories: leadership, organisational culture, information and communication technology infrastructure, reward and incentive system, KM strategy, knowledge audit, training and education, knowledge sharing, and knowledge capture. The CSFs have been then put into an ISM model to analyse the interaction between them. A hierarchical model of the CSFs was developed based on their significance by employing an ISM methodology. The developed model highlighted leadership (CSF1) and organisational culture (CSF2) as the most significant factors influencing the implementation of KM strategies in the KSA public sector organisations. The ISM-based model developed in this study provides decision-makers with a more realistic representation of the CSFs for implementing KM strategies in the KSA public sector organisations. The results demonstrated that leadership is the most important critical success factor for implementing KM strategies in the KSA public sector organisations.
Practical implication of this research would meet the Saudi Vision 2030, public sector organisations must show leadership. The scarcity of knowledge and expertise is, and will continue to be, a huge challenge for many organisations regardless of sector. The key to successful deployment of KM strategies lies in having a balance between the human, technological and process aspects of KM. It is imperative that public sector organisations view KM as a strategic tool and feel confident and positive about its impact on performance in the long term. It is essential to address the nine CSFs during the conceptualisation, design and implementation stages of KM programmes. This research has made significant original contributions, particularly on CSFs for implementing KM strategies in the KSA using an interpretive structural modelling (ISM) approach. It also gives valuable insight and guidance which will help the public sector decision-makers to accomplish KM strategies effectively.
Despite the novel insights provided by this study, it has some limitations. Given that the research reported in this chapter is largely exploratory by nature and participants were managers and directors only, the results presented are only tentative and of limited value for the purpose of generalisation. Furthermore, the findings of this chapter are limited to the KSA public sector organisations only; as such, the level of applicability outside this context may be very limited. However, we argue that the results obtained are useful to similar developed countries. Extending this study using a larger sample with more balanced representation across different public sector organisations will provide relevance of these findings to other countries’ public sector organisations. Furthermore, attitudes and behaviours towards knowledge sharing vary across national cultures. Therefore, this may limit the applicability of the findings to other countries or regions.
Eosinophils are leukocytes (white cells) found in the peripheral blood, hematopoietic, lymphatic organs, the bone marrow, spleen, and thymus, and can migrate to connective tissues and digestive tract; they are part of the group of leukocytes called granulocytes, along with basophils and neutrophils. They were described by P. Ehrlich in 1879 calling them eosinophils because their acidic granules in the cytoplasm were stained by their affinity dye aniline-eosin giving them the form of red-orange ammunition observed by optical microscopy: They are rounded cells from 8 to 15 μm in diameter, with a bilobed core with a fine nuclear bridge joining both lobes [1].
\nIdentification and quantification.
\nMethodology: Manual count in Neubauer chamber and automatic hematology analyzer using impedance and colorimetry and flow cytometry CD16 (FcƳRIII-CD16). Under normal conditions peripheral blood eosinophils represent 1–5% of total leukocytes, with an upper limit of 0.4 × 109 L,, the absolute eosinophilic count (AEC) of 350–500/mm3 and in children is greater than 0.75 × 109 L, increasing the number of eosinophils (eosinophilia) to more than 3–5 times which is indicative of an activity of infectious, parasitic, allergic, and eosinophilic and hypereosinophilic disorders [1, 2, 3, 4, 5].
\nThey originate in the bone marrow, by a process of maturation and differentiation that lasts approximately 8 days (hematopoiesis) from a pluripotential precursor cell (stem cell) differentiating itself as myeloid granulocytic line, under the influence of IL-3, IL-4 - granulocytic colony stimulation factor (GM-CSF) of eotaxin; evolving toward a mixed eosinophil-basophilic precursor and then differentiating toward eosinophils by action of IL-3, GM-CSF, and especially IL-5, they have a survival of 6–12 hours before moving to tissues where they remain between 2 and 5 days; once there is a stimulus, they respond by exercising their multiple functions regulated by T lymphocytes (Figure 1) [1, 2, 6].
\nScheme representing hematopoiesis, origin of eosinophil and its main functions associated with eosinophilic disorders. Molecules expressed on its surface (FcεRI-CD23-IgE). CCR4, CD88,H4R. Adhesion molecules: CD11b, CD11c, CD62L, and chemokines that attract eosinophils from blood to tissues [
The text begins with: Its main functions are the defense against parasites, helminths, nematodes, participate in allergic responses, inflammatory processes, restoration, and tissue repair; since they have specific chemotactic receptors on their membrane, eotaxin, cytokines (IL-3 -IL-5 and GM-CSF), eosinophil chemotactic factor of anaphylaxis (ECF-A); and nonspecific such as f MLP (from the wall of bacteria), complement activation products (C3a, C5a, C6, and C7), platelet-activating factor (PAF), leukotrienes (LTB 4 and LTD 4), histamine and IL-8. Diapedesis is mainly performed by integrins to adhere to the vascular endothelium (e.g., LFA-1-ICAM-1, the VLA-VCAM-1) and other multiple antibody receptors: IgA (Fc α R1-CD89), (FcεRIII-CD23-IgE), (FcƳεRI-degranulation), (FcƳRI-CD64-IgG1, IgG3 respiratory burst induction of microbial death), (FcƳA-CD32-Ig G1-degranulation), (FcƳRIIB-CD32-IgG1-No Phagocytosis, inhibition of cellular activity) (Figure 1) [2, 6, 8].
\nGranular content: Eosinophil mature contains in its cytoplasm primary granules rich in phospholipase A, rich in crystalline proteins of Charcot-Leyden-specific secondary granules containing the major or main basic protein (MBP), the eosinophilic peroxidase (EPO), eosinophilic protein (ECP)), and eosinophil-derived neurotoxin (EDN) that also appears in basophils and neutrophils; its response capacity is less than 1 hour, small granules containing arylsulfatase B and acid phosphatase and five lipid bodies main source of arachidonic acid, can be presenting cells, proliferation of T lymphocytes and basophils are capable of deliberating more than 35 cytokines, chemokines, and growth factors (Figure 1) [5, 9].
\nThe severity of eosinophilia has been arbitrarily divided into mild (AEC from the upper limit of normal to 1500/mm3), moderate (AEC 1500–5000/mm3), and severe (AEC >5000/mm3).
\nThe classification of eosinophilic diseases was revised in 2008 and reaffirmed in 2016. In 2017 its diagnosis, risk stratification (prognosis), and management (treatment) proposed by the World Health Organization were covered [10].
\nEosinophilic diseases can be classified in two types: primary, intrinsic hematology due to clonal disorders, and secondary, extrinsic or reactive disorders to an external cause that cause damage to different organs. Primary eosinophilias or clonal disorders can be diagnosed by studying the blood and bone marrow by the following methods: standard cytogenetics, molecular biology with monoclonal antibodies, flow cytometry, in situ hybridization, and evaluation of T cell clonality.
\nThe major category of primary diseases corresponds to myeloid/lymphoid neoplasms with eosinophilia and rearrangements PDGFRA, PDGFRB, or FGR1; with PCMiJAK2 and MPN, a subtype of chronic eosinophilic leukemia or not specified by CEL-NOS, there is another lymphoid-eosinophilic variant of aberrant T cell clone.
\nThe modern definition of hypereosinophilic syndrome (HES) is a vestige of the historical criteria outlined by Chusid and colleagues in 1975: The absolute eosinophil count is >1500/mm3 for more than 6 months, and tissue damage is present [10, 11].
\nThe Working Conference on Eosinophil Disorders and Syndromes proposed a new terminology for eosinophilic syndromes. Hypereosinophilia (HE) for persistent and marked eosinophilia (AEC >1500/mm3) in turn, HE subtypes were divided into a hereditary (familiar) variant (HEfa); HE of undetermined significance (HEus), primary (clonal-neoplastic), HE produced by clonal/neoplastic eosinophils (HEn), and secondary (reactive) (HEr) can be considered a provisional diagnosis until a primary or secondary cause of eosinophilia is ascertained [12].
\nTo have to a better understanding of the pathogenetic aspects of eosinophilia, other classifications of eosinophilic diseases were generated according to the site of eosinophilic infiltration associated with organ damage and dysfunction. The primary cause of eosinophilia located within the eosinophils (and/or eosinophil precursors) themselves or in other cells, similar to allergic diseases, can be divided in IgE-mediated (extrinsic) and non-IgE-mediated (intrinsic) diseases; the terms extrinsic and intrinsic eosinophilic disorders indicate whether the primary cause of eosinophilia is inside or outside the eosinophil lineage [11].
\nChronic eosinophilic leukemias belong to a special group of chronic myeloid leukemias, in which eosinophil differentiation is dominant, resulting in blood eosinophil counts of greater than 1500/mm3. However, other lineages are also affected, because the disease is the result of a mutation in a pluripotent hematopoietic stem cell. The chromosomal translocations related to breakpoints on chromosome 8p11 result in fibroblast growth factor receptor 1 fusion genes with increased kinase activity causing the so-called 8p11 syndrome. The increase in tyrosine kinase activity is caused by gene 1 and the growth factor, and this leukemia has a worse prognosis, which transforms chronic leukemia to an acute, 1–2 years. Another type of cause may be the increase in tyrosine kinase by fusion of the platelet growth factor alpha receptor genes (PDGFRA). PDGFRA is fused by the Fip1-like 1 (FIP1L1) gene as a result of a 4q12.9 chromosome damage. This is both in eosinophils and in other hematopoietic lineages such as neutrophils, monocytes, lymphocytes, and mast cells. This type of leukemia is pluripotent hematopoietic stem cell which responds to the tyrosine kinase inhibitor (imatinib) [10, 11].
\nMutations in multipotent myeloid stem cells: In the chronic myeloid leukemias with eosinophilia, eosinophils are part of the clone. This is because eosinophil differentiation is often not as prominent as other myeloid cells, such as monocytes, which also show increased differentiation. Chromosomal translocations related to breakpoints on chromosome 5q33 are common and represent the basis for the formation of platelet-derived growth factor receptor b (PDGFRB) fusion genes; this result increases the tyrosine kinase activity. There are patients with positive Philadelphia chromosome who can develop chronic leukemia with eosinophilia due to two factors: fusion by breakpoint cluster region-Abelson (ABL) and fusion of transcription gene 6 (ETV6). Marked eosinophilia often associated with a cytogenetic evolution and other accelerated phases of ABL can occur during an acute transformation; ABL may be fused with the transcription factor E26 by means of variant ETV6 triggering chronic leukemia [10].
\nMyelodysplastic syndromes: During hematopoiesis there may be an inefficient process in the differentiation of stem cell by mutations, malignant clones producing myelodysplastic syndromes that lead to myeloproliferative diseases such as polycythemia vera, essential thrombocythemia, and agnogenic myeloid metaplasia. The exact molecular genetic abnormalities resulting in eosinophilia in these disorders remain to be determined [10, 11].
\nT cell-mediated eosinophilias: The common diseases are allergic rhinoconjunctivitis, bronchial asthma, drug allergic, eosinophilic esophagitis, and atopic dermatitis. Eosinophilia and IgE production due to the polarization of TH2 cells whose causes are extrinsic or external by stimulation of environmental immunogens or chemical compounds, which are presented by APC-MHC, stimulating the release of pro-inflammatory cytokines (IL4, IL5, and IL13), induce the increase in eosinophils of IgE survival, high affinity receptors with PKC activation, cross-linking and signaling for histamine release, as well as vasoactive amines that produce inflammatory processes and organ damage [10, 11].
\nInfectious diseases: TH2 inflammatory responses are induced by helminths; these responses are characterized by IgE antibody production and eosinophilia; both have been implicated in mediating protective immunity to the parasites. In contrast, there is little doubt that eosinophils contribute to tissue damage and therefore to the pathogenesis of these infections.
\nViral infections are not common; however, when virus-specific T cells are generated in a TH2 environment, they can also release IL-5 and therefore trigger eosinophilia. In chronic rhinosinusitis, eosinophilia is related to fungal infections with certain molds (e.g., Alternaria) which is present in the nasal and paranasal cavities [5, 10, 11].
\nAutoimmune diseases: Because these diseases are often associated with a TH1-associated inflammatory response, eosinophilia is not frequent, but in systemic sclerosis, levels of major basic protein and extracellular major basic protein depositions were observed in skin and lung tissues. In primary biliary cirrhosis, eosinophilia is a distinctive feature that might be useful in the diagnosis of the disease [10, 11, 13].
\nGraft-versus-host diseases: When an allogeneic bone marrow transplant is carried out and there are differences in MHC molecule polymorphism, these can be recognized by the immune system, and responses can be made against the alloantigens, producing graft-versus- host-disease (GVHDs), carrying out a reaction antigen antibody, cellular or cytotoxic that produces lysis and destruction in specific organs (skin, liver, and gastrointestinal tract mainly).
\nDrug-induced diseases: Hypersensitivity drug reactions may present in some cases increased eosinophils. The manifestations range from maculopapular rashes of the skin to severe life-threatening drug reactions with eosinophilia and systemic symptoms (DRESS). Drugs and their metabolites can produce hypersensitivity by means of mechanisms mediated by APC-MHC TCR pi concept, generating TH2 polarity or TH1 with memory T cells [10, 11, 13].
\nThere are other subgroups of this syndrome as episodic angioedema and hereditary eosinophilia. Where there is evidence of mechanism mediated by IL-5-producing T cells [5].
\nSevere primary (IL-5) and secondary immunodeficiencies (HIV) are associated with eosinophilia when there is polarization of TH2 by the immunogen (allergen) or drug (antiretroviral); infections such as tuberculosis are the cause of infections and resistance to treatment (Figure 2) [11].
\nDiagnostic algorithm for patients with hypereosinophilia. Due to the fact that eosinophilia can occur in different pathologies, an exclusion of the unlikely causes for hypereosinophilia is performed, in addition to a three-step follow-up treatment with imatinib due to mutation processes that is considered. Laboratory tests would be at the discretion of the doctor according to the medical history and the search according to the type of response to the genes involved [
Corticosteroids should be considered a first-line treatment, which are potent anti-eosinophil agents, effective in producing rapid reductions. Maximal dose was 1 mg × kg 2 months, with symptom control and reduction of the eosinophil count to below 1500/mm3 after 1 month of treatment.
\nHydroxyurea is an effective first-line agent for HES which may be used in conjunction with corticosteroids or in steroid nonresponders. A typical starting dose is 500–1000 mg daily which can serve as effective palliative to control leukocytosis and eosinophilia but with no proven role in favorably altering the natural history of HES or CEL-NOS (Figure 2) [10, 12, 14].
\nIFN-a has demonstrated hematologic responses and reversion of organ injury in patients with HES and CEL-NOS refractory to therapies including prednisone and/or hydroxyurea. Remissions have been associated with improvement in clinical symptoms and organ disease, including hepatosplenomegaly, cardiac and thromboembolic complications, mucosal ulcers, and skin involvement [5, 10, 11, 12].
\nMepolizumab anti-IL-5 antibody is a fully monoclonal IgG antibody that inhibits binding of IL-5 chain of the IL-5 receptor expressed on eosinophils [5, 14].
\nAlemtuzumab is an anti-CD52 monoclonal antibody that has been evaluated in idiopathic HES based on expression of the CD52 antigen on eosinophils. In patients with refractory HES, alemtuzumab was administered intravenously at a dose of 5–30 mg once to thrice weekly.
\nBone marrow/peripheral blood stem cell allogeneic transplantation has been attempted in patients with aggressive disease; a disease-free survival ranging from 8 months to 5 years has been reported.
\nImatinib is a small-molecule tyrosine kinase inhibitor 100 mg per day; it also shows activity against platelet-derived growth factor receptor (PDGF-R), c-Kit, Abl-related gene (ARG), and their fusion proteins while sparing other kinases (Figure 3) [10].
\nDiagnostic and treatment algorithm based on revised 2016 WHO classification of eosinophilic disorders. According to the algorithm, the type of eosinophilia can be monitored according to the cases where other drugs other than imatinib should be used, with three pathological options being present: chronic leukemia with eosinophilia, idiopathic hypereosinophilia, and lymphocyte variant, all share the administration of imatinib and corticosteroids (idiopathic hypereosinophilia and lymphocyte variant) [
Mastocytosis: Develops from a neoplastic proliferation of mast cells. It develops from a neoplastic clonal proliferation of mastocytes that accumulate in one or more organ systems and are organize as compact cohesive aggregate groups or multifocal groups of abnormal mastocytes. This disorder is diverse; it can be found as cutaneous lesions that may naturally recede, to highly aggressive neoplasias related with multiple organ failure and short outliving. Mastocytosis subtypes are principally characterized by the clinical manifestations and the spread of the disease. When cutaneous mastocytosis (CM) occurs, mastocyte infiltration is restricted to the skin, whereas systemic mastocytosis (SM) includes at least one extracutaneous organ, with or without skin lesions. Mastocytosis must be distinguished from mastocyte hyperplasia or from the mastocyte activation states, without the morphological or molecular abnormalities that characterize neoplastic proliferation [15]. The WHO classification includes seven types:
Cutaneous mastocytosis
Indolent systemic mastocytosis (ISM)
Systemic mastocytosis with associated clonal, hematologic non-mast cell lineage disease (SM-AHNMD)
Aggressive systemic mastocytosis (ASM)
Mast cell leukemia (MCL)
Mast cell sarcoma (MCS)
Extracutaneous mastocytoma
Hypereosinophilic syndrome (HES): It has been described as a condition associated with persistent eosinophilia in the peripheral blood, organ damage, and exclusion of any other underlying disease or condition that may explain eosinophilia or organ damage [4, 16, 17, 18]. The diagnostic algorithm must begin with the evaluation of peripheral blood hypereosinophilia (HE), defined as a persistent increase of blood eosinophils, above 1.5 X 109/L blood [4, 16, 17, 18]. The term “tissue HE” has also been proposed, and it may be useful in the evaluation and the classification of the disorders related to HES [16, 19]. The establishment of an HES diagnosis must be considered: (a) the existence of an underlying disease or condition and (b) the presence of clinical signs and symptoms or laboratory abnormalities that show organ damage induced by HE (HES) [19]. There are four important groups of underlying disorders in patients with documented HES:
Hematopoietic neoplasias
Other neoplasias (non-hematopoietic) (paraneoplastic HE)
Common allergic, reactive, or immunological conditions
Infrequent clinical syndromes that present HE, including rare hereditary disorders [19]
Lymphoid and myeloid leukemias: Many hematologic disorders may present eosinophilia, but only a few present clonal (primary) neoplasias, and just a small number of neoplasms present HE and organ damage. Myeloid neoplasias that present HE include rare acute eosinophilic leukemia types. The most common type of chronic leukemia is chronic eosinophilic leukemia (CEL), which is frequently associated with the FIP1L1-PDGFRA rearrangement in endomyocardial fibrosis/thrombosis and other myeloid neoplasias with rearrangements, such as the 8p11 syndrome [19, 20]. Clonal eosinophilia is frequently observed in advanced cases of systemic mastocytosis [19, 21, 22].
\nLymphoid neoplasms may present HE, and in most cases, a T cell lymphoma is diagnosed. Nevertheless, in such patients with 8p11 syndrome and other rare entities, both eosinophils and lymphocytes may be involved in the neoplastic clonal processes [19, 21].
\nParaneoplastic conditions associated with hypereosinophilia. Different types of cancers may be preceded or accompanied by eosinophilia. Cancers associated with HE include lung, gastrointestinal tract, pancreas, and thyroid adenocarcinomas, gynecologic tumors, and skin cancer. Although pathogenesis is unclear, there is a widely accepted hypothesis stating that carcinogenic cells or cancer or the cancer microenvironment around fibroblasts produce eosinophilopoietic cytokines [19, 23].
\nIdentification and quantification.
\nClassic methodology: Clinical manifestations and diagnosis depend on the type of disease and other factors, where different organs may be involved in patients with HES, for example, skin, gastrointestinal tract, heart, and central nervous system.
\nIn order to establish an HES diagnosis, it is recommended to include clinical and laboratory parameters, such as:
Physical exam of organs and body systems
Laboratory exams: white blood cell count (eosinophils, basophils, neutrophils), hemoglobin, platelet count, B12 vitamin, hepatic enzymes, kidney function tests, and urinalysis
Organic functional tests: electrocardiogram, echocardiogram, pulmonary function tests, chest computed tomography and radiography, abdominal ultrasound, and normal endoscopic study [19]
Molecular detection of some translocations, such as TCR, BCR/ABL1, JAK2 V617F, KITD816V, PDGFRA/PDGFRB, and FGR1
Immunoglobulins rearrangements are detected by real-time polymerase chain reaction with TaqMan molecular probes, such as TCR, BCR/ABL1, JAK2 V617F, KITD816V, PDGFRA/PDGFRB, and FGR1. The most recommended bone marrow exams are cytogenetic assays and fluorescence in situ hybridization (FISH)—other studies which do not include molecular detection are tissue immunohistochemistry and histology (Figure 4) [16].
\nFlow diagram to perform real-time PCR. In a simplified way, the preparation of the sample with its corresponding primer and the distribution of the samples for its reaction are shown, which can be seen in real time by monitoring the amplification as the cycles in the thermal cycler pass.
The WHO defines an ADR to any predictable noxious reaction that appears at therapeutic doses, depends on the doses, and is related to pharmacological actions. Other unpredictable reactions: hypersensitivity or allergic (DHRs) associated with immunological mechanisms, susceptibility (atopy), and polymorphism (pharmacogenetic, MHC-HLA) [24, 25, 26, 27].
\nIt is considered as a public health problem due to its high morbidity and mortality being 20%; hence, the importance of its clinical diagnosis and laboratory tests is being considered at all stages of life (prenatal, postnatal, childhood, adolescence, adult, and older adult).
\nMedications are usually non-immunogenic haptens of different types:
\nPro-haptens. Drugs are generally non-immunogenic haptens of different types: Pro-haptens (non-active reagents) low molecular weight chemicals of less than 1000 D; examples aromatic, heterocyclic, sulfonamides, OH, halogens, resonance, and beta-lactam are processed and presented in the CPA-MHC context and produce a humoral response, IgE, IgG and IgM or cellular.
\nActive reagents: aromatic, polar, with nitrogen, to induce an immune response CPA-MHC.
\nInert TCR pi (pharmacological interaction with immune receptors): Some drugs are able to bind non-covalently to TCR pi receptors pre-developed by a previous immune response to a non-covalently reversible drug and signaling toward a response of hypersensitivity and explain the rapid appearance of symptoms, some cross reactions to the drug, or its metabolites.
\nPi concept and HLA restriction in hypersensitivity: In the pi concept, drugs primarily activate TCR, for example, abacavir associated with the HLA-B * 5701 allele in whites, Stevens-Johnson syndrome (SJS) with carbamazepine treatment in Chinese associated in patients with the HLA-B * 1502, and HLA-B * 5801 allele in allopurinol-induced adverse reactions such as SJS and toxic epidermal necrolysis (TEN) [28, 29, 30, 31].
\nHypersensitivity is an exacerbated immune response, which produces a clinical picture with dermal, systemic disorders, and sometimes sudden death. In 1930 Coombs systematized these reactions according to the period of time in which the symptoms appear, and the dose of challenge has been fundamental to guide the diagnosis, treatment, and monitoring. It has many points in common with autoimmunity, where the antigens are their own; in the case of allergies to medications, the antigens are allergens: drugs or metabolic derivatives. Hypersensitivity reactions require that the individual has been previously sensitized or exposed to at least the antigens in question. The classification of allergic or hypersensitivity reactions into four types (I, II, III, and IV) and subsequently Pichler in 2003 proposed the subdivision of type IV into IVa, IVb, IVc, and IVd (Table 1) [28, 29].
\nType | \nType of immune response | \nClinical symptoms | \nIn vitro diagnostics | \nIn vivo diagnostics | \n
---|---|---|---|---|
I | \nMeasured by IgE eosinophils, mast cells, and basophils (immediate) | \nUrticaria Angioedema Rhinitis Bronchospasm Anaphylaxis | \nIgE specific Serum tryptase Cell stimulation test (CAST) BAT(MDB, CD63) | \nCutaneous tests (prick, intradermal) Challenge tests Proving tests [Coombs] | \n
II | \nCytotoxicity dependent on IgG and IGM antibodies (not immediate) and complement | \nHemolytic Anemia Thrombocytopenia Neutropenia Autoimmunity | \nCoombs test Ab vs. platelets Ab vs. neutrophils | \nOnly challenges to the drug can make diagnosis but are high risk [Coombs] | \n
III | \nDeposit of immunocomplexes [IgG and IgM] (not immediate) Complement or FcR | \nSerum disease Vasculitis, LES-like by medications Glomerulonephritis drug | \nC3, C4, ANA, ANCA, CCP, antithyroid, etc. Liver and kidney function tests Pathological anatomy | \nBiopsies with immunofluorescence [Coombs] | \n
IVa | \nTH1 (IFNγ), TNFα, IL12, and macrophages (late) | \nContact dermatitis | \nLymphocyte transformation test (LT or BT), MLIF, cytotoxic T lymphocyte precursors (CTLp), cytokines (ELISA, PCR) | \nPatch tests [Pichler] | \n
IVb | \nTH2 (IL-4, IL5, IL13) eosinophils | \nMaculopapular eruptions (MPE) with eosinophilia (DRESS) | \nCBC with check eosinophil cellularity, atypical lymphocytes MLIF, BT, LT | \nPatch tests [Pichler] | \n
IVc | \nCLT, CD4/CD8 (perforin, granzyme B, Fas L) | \nContact dermatitis, maculopapular, and bullous diseases(SJS), TEN | \nMLIF, liver function tests, CD4/CD8 (death keratinocytes) Activity of IgM vs. herpes virus, Epstein-Barr, and cytomegalovirus (CMV) | \nPatch tests [Pichler] | \n
IVd | \nT cells, IL8, CXCL8 cells Neutrophils Inflammation | \nAcute generalized exanthemic pustulosis (AGEP) pharmacodermias associated with neutrophilia | \nCBC T cells CD4/CD8 | \nPatch tests [Pichler] | \n
Hypersensitivity classification according to the Gell and Coombs modified by Sell, Pichler, and ICON.
Hypersensitivity reactions require that the individual has been previously sensitized or exposed at least once to the antigens in question. The classification of allergic or hypersensitivity reactions into four types (I, II, III, and IV) and subsequently Pichler in 2003 proposed the subdivision of type IV into IVa, IVb, IVc, and IVd [27, 28, 29].
Modified basophil degranulation (MBD): The test is a basophil activation test (BAT) which consists of incubating the basophils in vitro with the suspected drug to be carried out: epitope-paratope binding, activating the basophils and causing degranulation and release of the aforementioned content (specificity 100%, sensitivity 84.0%) [28, 29].
\nCD63 flow cytometry: Basophils with specific IgE when incubated with the suspected drug are activated by Fcε I receptors; high affinity and low affinity cause cross-linking and protein kinase signal transduction (MAP, PKC) that stimulate expression of the receptor (CD63) -gp53 (lysosomal-transmembrane protein tetraspanin LAMP-31) on the surface of the basophil while the eosinophilic expresses CD23 [30].
\nModified leukocyte migration inhibition factor (MLIF) type IV a, b, and c. Associated with anaphylactic degranulation: It has been reported that leukocytes including basophils (BAT-Chemotaxis) also play a role in directional chemotaxis; therefore, when microhematocrits are incubated in Bloom chambers with medications in two dilutions (1 and 0.1 mg/mL) in an RPMI medium, with negative and positive controls, at 37°C, the first (20 min at 2 hours) and delayed migration can be measured (4, 6, and 18 hours); the % of MLIF can also be calculated against the negative control, as well as the reference values (RV) for MLIF (0–25% inhibition of leukocyte migration) [29].
\nEosinophilia in the peripheral blood is a common cause in patients who consume medications, especially in developed countries, who are monitored and can restrict their consumption without changes. However, for the doctor, concern may arise in cases of impending hypersensitivity reaction (HSR). Severe HSRs associated with peripheral blood may include specific reactions of organs (heart, kidney, liver, lungs, joints, central nervous system, and skin) and adverse skin reactions (SCAR) where SJS, TEN, and DRESS are included [32, 33].
\nThe prolongation of eosinophilia can cause tissue damage, although without being clarified specifically, adding to the condition infections as another factor that preserves eosinophilia (parasitic and fungal infestations) or decreases (eosinopenia due to bacterial and viral infections). The diagnosis can be complicated because of the presence of the drug which worsens a preexisting eosinophilia, particularly in atopic patients [33].
\nDRESS is more common in adult patients than in children, with approximately 50 drugs being described, highlighting anticonvulsants (phenytoin, phenobarbital, and carbamazepine) and antibiotics as the main causes of the syndrome and, to a lesser extent, sulfate derivatives, antidepressants, NSAIDs, and antidiuretics [34]. There is no clear association between variability of the type of drug and the affected organ with the degree of eosinophilia, which can be mild or self-limited and severe when multisystemic complications are generated due to the presence of symptoms that are not appreciated in the mild form [32, 33].
\nOther proposals that lead to the pathogenesis of DRESS include detoxification defects at the time of the formation of reactive metabolites, slow acetylation, and reactivation of the human herpes virus (HHV-6-7) or EBV [34].
\nIn general, the diagnostic algorithm for eosinophilia linked to SCAR can be visualized as a hypersensitivity response type IVb (SJS and NET) and type IVc (DRESS), which in some way can highlight the pathogenesis proposals previously mentioned not only by DRESS but identify an atopic patient (Table 1).
\nEosinophils are leukocytes (white blood cells) found in the peripheral blood, hematopoietic, lymphatic organs, thymus, connective tissue, and digestive tract. They are identified and quantified by manual counting (Neubauer chamber), automated count with autoanalyzer hemocytometers (impedance, colorimetry, and differential in optical microscope), flow cytometry after the advent of monoclonal antibodies, currently the most used to identify surface markers and immunoenzymatic methods (ELISA, RAST, IMMUNOCAP) for cytoplasmic granules.
\nThe classification of eosinophilic diseases “eosinophilic disorders” was revised in 2008 and confirmed in 2016; its study focused on external (extrinsic) and internal (intrinsic) causes (optimized) and optimized and failed diagnosis by precise and timely diagnosis. The algorithms are used and started with the main pillar: The clinical history (clinical criteria, anamnesis, and exploitative maneuvers leading to clinical laboratory algorithms, with initial, basic, and special tests including imaging, tomography, and X-rays to finally improve the prognosis and modify the natural history. The intrinsic and extrinsic disorder algorithm planting is different; this is due to the recognition of molecular altered T cell clones, bone marrow studies, and markers of apoptotic genes, PCM1-JAK2, Fas L, and bcl2.
\nSome allergies to medications with symptomatology related to specific organ and severe cutaneous against antiepileptics (phenytoin, phenobarbital, carbamazepine) as well as other medications (antibiotics, NSAIDs, antidiuretics) can be related, which rethinks the proposed immunological response algorithm not only in basophil evaluation but also the search for eosinophils in flow cytometry or optical microscopy to assess not only damage but neutralization (eosinophil histaminase).
\nCorticosteroids are considered the first line of treatment because of their potent anti-eosinophilic effect for disease control, prognosis, and prevention. So the new treatment alternatives could displace steroids with monoclonal antibodies such as the IL-5 inhibitor that show less long-term toxicity.
\nThanks to the headquarters and staff of the Department of Allergy and Immunology of the Juarez Hospital of Mexico, Dr. Ruben Humberto Meyer Gomez of the Angeles Hospital, and the laboratory technician Isabel Guerrero Vargas of the LCEIL Laus Deo.
\nThere is no conflict of interest.
\n absolute eosinophil count hypersensitivity reaction severe cutaneous adverse reaction Stevens-Johnson’s syndrome toxic epidermal necrolysis drug rash eosinophilia and systemic symptoms complete blood count drug hypersensitivity reaction
IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors. To that end we maintain a flexible Copyright Policy guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
',metaTitle:"Publication Agreement - Journals",metaDescription:"IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors",metaKeywords:null,canonicalURL:"/page/publication-agreement-journals",contentRaw:'[{"type":"htmlEditorComponent","content":"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Journal Article:
\\n\\n1. DEFINITIONS
\\n\\nCorresponding Author: The Author of the Article who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author. Co-Author: All other Authors of the Article besides the Corresponding Author. IntechOpen: IntechOpen Ltd., the Publisher of the Journal.
\\n\\nJournal: The publication as a collection of Articles compiled by IntechOpen .
\\n\\nArticle: The original literary work created by Corresponding Author and any Co Author that is the subject of this Agreement.
\\n\\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\\n\\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\\n\\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\\n\\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\\n\\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\\n\\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\\n\\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\\n\\n3. CORRESPONDING AUTHOR'S DUTIES
\\n\\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\\n\\n3.2 When submitting the Article, the Corresponding Author agrees to:
\\n\\n• Comply with all instructions and guidelines provided by IntechOpen;
\\n\\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\\n\\n• Submit all the corrections in due time as defined during the publishing process schedule.
\\n\\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\\n\\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\\n\\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\\n\\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\\n\\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n"}]'},components:[{type:"htmlEditorComponent",content:"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Journal Article:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Article who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author. Co-Author: All other Authors of the Article besides the Corresponding Author. IntechOpen: IntechOpen Ltd., the Publisher of the Journal.
\n\nJournal: The publication as a collection of Articles compiled by IntechOpen .
\n\nArticle: The original literary work created by Corresponding Author and any Co Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Article, including the right to deposit the Article in open access digital repositories.
\n\n• An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Article in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Article under a Creative Commons 4.0 International Licence).
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Article but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Article as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world. The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Article and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Article.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Article as a consequence of IntechOpen's changes to the Article arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Article, the Corresponding Author agrees to credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Journal in which the Article has been published as the source of first publication, as well as IntechOpen, when they are distributing or re publishing the Article.
\n\n3.2 When submitting the Article, the Corresponding Author agrees to:
\n\n• Comply with all instructions and guidelines provided by IntechOpen;
\n\n• Produce the Article with all due skill, care and diligence, and in accordance with good scientific practice;
\n\n• Submit all the corrections in due time as defined during the publishing process schedule.
\n\nThe Corresponding Author will be held responsible for the payment of the Article Processing Charge.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Article worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Article does not and will not breach any applicable law or the rights of any third party and, specifically, that the Article contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Article is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Article has not been formally published in any other peer-reviewed journal or in a Journal or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication
\n\nAgreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Article to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Article was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Article on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Article attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Article and has the right to contact the Corresponding Author and any Co-Author until the Article is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Article,
\n\nIntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
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I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. 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Marquis, Éric Guillaume and Carine Chivas-Joly",authors:[{id:"44307",title:"Dr",name:"Damien",middleName:"Michel",surname:"Marquis",slug:"damien-marquis",fullName:"Damien Marquis"},{id:"44317",title:"Prof.",name:"Carine",middleName:null,surname:"Chivas-Joly",slug:"carine-chivas-joly",fullName:"Carine Chivas-Joly"}]},{id:"52860",doi:"10.5772/65937",title:"Cerium Oxide Nanostructures and their Applications",slug:"cerium-oxide-nanostructures-and-their-applications",totalDownloads:5365,totalCrossrefCites:23,totalDimensionsCites:55,abstract:"Due to excellent physical and chemical properties, cerium oxide (ceria, CeO2) has attracted much attention in recent years. This chapter aimed at providing some basic and fundamental properties of ceria, the importance of oxygen vacancies in this material, nano‐size effects and various synthesis strategies to form diverse structural morphologies. Finally, some key applications of ceria‐based nanostructures are reviewed. We conclude this chapter by expressing personal perspective on the probable challenges and developments of the controllable synthesis of CeO2 nanomaterials for various applications.",book:{id:"5510",slug:"functionalized-nanomaterials",title:"Functionalized Nanomaterials",fullTitle:"Functionalized Nanomaterials"},signatures:"Adnan Younis, Dewei Chu and Sean Li",authors:[{id:"191574",title:"Dr.",name:"Adnan",middleName:null,surname:"Younis",slug:"adnan-younis",fullName:"Adnan Younis"}]}],mostDownloadedChaptersLast30Days:[{id:"71103",title:"Preparation of Nanoparticles",slug:"preparation-of-nanoparticles",totalDownloads:3140,totalCrossrefCites:11,totalDimensionsCites:25,abstract:"Innovative developments of science and engineering have progressed very fast toward the synthesis of nanomaterials to achieve unique properties that are not the same as the properties of the bulk materials. The particle reveals interesting properties at the dimension below 100 nm, mostly from two physical effects. The two physical effects are the quantization of electronic states apparent leading to very sensitive size-dependent effects such as optical and magnetic properties and the high surface-to-volume ratio modifies the thermal, mechanical, and chemical properties of materials. The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:72,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:78,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:124,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",isOpenForSubmission:!0,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",isOpenForSubmission:!0,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. 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Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}]},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",biography:"Dr. Emad Shalaby is a professor of biochemistry on the Biochemistry Department Faculty of Agriculture, Cairo University. He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:5,paginationItems:[{id:"11576",title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",hash:"5a01644fb0b4ce24c2f947913d154abe",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 26th 2022",isOpenForSubmission:!0,editors:[{id:"76041",title:"Prof.",name:"Pier Paolo",surname:"Piccaluga",slug:"pier-paolo-piccaluga",fullName:"Pier Paolo Piccaluga"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11577",title:"Tick-Borne Diseases - A Review and an Update of Knowledge on Infections in Human and Animal Population",coverURL:"https://cdn.intechopen.com/books/images_new/11577.jpg",hash:"3d72ae651ee2a04b2368bf798a3183ca",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 29th 2022",isOpenForSubmission:!0,editors:[{id:"51521",title:"Prof.",name:"Elisa",surname:"Pieragostini",slug:"elisa-pieragostini",fullName:"Elisa Pieragostini"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11570",title:"Influenza - New Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11570.jpg",hash:"157b379b9d7a4bf5e2cc7a742f155a44",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"139889",title:"Dr.",name:"Seyyed Shamsadin",surname:"Athari",slug:"seyyed-shamsadin-athari",fullName:"Seyyed Shamsadin Athari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11569",title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",hash:"069d6142ecb0d46d14920102d48c0e9d",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"May 31st 2022",isOpenForSubmission:!0,editors:[{id:"189561",title:"Dr.",name:"Mihaela Laura",surname:"Vica",slug:"mihaela-laura-vica",fullName:"Mihaela Laura Vica"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11568",title:"Staphylococcal Infections - Recent Advances and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11568.jpg",hash:"92c881664d1921c7f2d0fee34b78cd08",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"59719",title:"Dr.",name:"Jaime",surname:"Bustos-Martínez",slug:"jaime-bustos-martinez",fullName:"Jaime Bustos-Martínez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. His research interests include biochemistry, oxidative stress, reactive species, antioxidants, lipid peroxidation, inflammation, reproductive hormones, phenolic compounds, female infertility.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"14",type:"subseries",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. 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