\r\n\tThis book will describe the self-assembly of materials and supramolecular chemistry design principles for a broad spectrum of materials, including bio-inspired amphiphiles, metal oxides, metal nanoparticles, and organic-inorganic hybrid materials. It will provide fundamental concepts of self-assembly design approaches and supramolecular chemistry principles for research ideas in nanotechnology applications. The book will focus on three main themes, which include: the self-assembly and supramolecular chemistry of amphiplies by coordination programming, the supramolecular structures and devices of inorganic materials, and the assembly-disassembly of organic-inorganic hybrid materials. The contributing chapters will be written by leading scientists in their field, with the hope that this book will provide a foundation on supramolecular chemistry principles to students and active researchers who are interested in nanoscience and nanoengineering fields.
",isbn:"978-1-83969-702-9",printIsbn:"978-1-83969-701-2",pdfIsbn:"978-1-83969-703-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"e9cc643ae0a219e91e445a1e61b33a22",bookSignature:"Prof. Hemali Rathnayake and Dr. Gayani Pathiraja",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11908.jpg",keywords:"Amphiphiles, Artificial Siderophores, Coordination Chemistry, Self-Assembly Design, Supramolecular Structures, Metal Oxides, Metal Particles, 2D Inorganic Materials, Supramolecular Devices, Stimuli-Responsive Materials, Assembly-Disassembly Design, Superstructures",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 27th 2022",dateEndSecondStepPublish:"July 1st 2022",dateEndThirdStepPublish:"August 30th 2022",dateEndFourthStepPublish:"November 18th 2022",dateEndFifthStepPublish:"January 17th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"17 hours",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Rathnayake is a pioneering researcher in self-assembly and supramolecular chemistry, with a Ph.D. from the University of Massachusetts Amherst, US. She is an inventor of three innovative technologies, including the Bioinspried Sub-7 nm self-assembled structures for patterning, and holder of multiple registered patents.",coeditorOneBiosketch:"Dr. Gayani Pathiraja is a Postdoctoral Research Scholar at the Joint School of Nanoscience and Nanoengineering (JSNN). She received her Ph.D. in Nanoscience from the University of North Carolina at Greensboro in 2021. Her research interests focus on the crystal growth mechanism and kinetics of metal oxide nanostructure formation via self-assembly.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"323782",title:"Prof.",name:"Hemali",middleName:null,surname:"Rathnayake",slug:"hemali-rathnayake",fullName:"Hemali Rathnayake",profilePictureURL:"https://mts.intechopen.com/storage/users/323782/images/system/323782.jpg",biography:"Dr. Hemali Rathnayake, Associate Professor in the Department of Nanoscience at the Joint School of Nanoscience and Nanoengineering, the University of North Carolina at Greensboro, USA, obtained her B.S. in Chemistry from the University of Peradeniya in Sri Lanka. She obtained her Ph.D. from the University of Massachusetts Amherst (UMass), Department of Chemistry in 2007. She was a Postdoctoral research fellow at Polymer Science & Engineering, UMass Amherst. \r\nDr. Rathnayake is a pioneer scientist and a chemist in the field of Nanomaterials Chemistry, with a focus on the interfacial interaction of nanomaterials, molecules, macromolecules, and polymers in homogeneous and heterogeneous media. Her research on the design, synthesis, self-assembly, and application of well-defined superstructures in nanoelectronics, environmental remediation, and sustainable energy has impacted the scientific community with highly rated peer-reviewed journals publications, and more than 80 invited talks to scientific and non-scientific communities including colleges and high schools.",institutionString:"University of North Carolina at Greensboro",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of North Carolina at Greensboro",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:{id:"427650",title:"Dr.",name:"Gayani",middleName:null,surname:"Pathiraja",slug:"gayani-pathiraja",fullName:"Gayani Pathiraja",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003CCSN2QAP/Profile_Picture_1644217020559",biography:"Dr. Gayani Pathiraja is a Postdoctoral Research Scholar at the Joint School of Nanoscience and Nanoengineering (JSNN). She received her Ph.D. in Nanoscience from the University of North Carolina at Greensboro (UNCG) in 2021. Her expertise area of focus is investigating the crystal growth mechanism and kinetics of metal oxide nanostructure formation via in-situ self-assembly design principles. \r\nDr. Pathiraja earned her master’s degree in electrochemistry/Environmental Engineering from the University of Peradeniya, Sri Lanka, and her Bachelor’s degree in Materials Science and Technology from Uva Wellassa University, Sri Lanka. Dr. Pathiraja started her academic career as a lecturer at the Department of Engineering Technology, University of Ruhuna, Sri Lanka in 2016. She is a co-author of several peer-reviewed journal publications and a book chapter, and she has presented her work at several regional, international, and national conferences.",institutionString:"University of North Carolina at Greensboro",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of North Carolina at Greensboro",institutionURL:null,country:{name:"United States of America"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"8",title:"Chemistry",slug:"chemistry"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"69950",title:"Sustainable Rural Development under Agenda 2030",doi:"10.5772/intechopen.90161",slug:"sustainable-rural-development-under-agenda-2030",body:'\nThe rural environment is a complex system in which the differences in development are evident both at the subnational and international level. The difficulties related to methodological analysis are due to such rural diversity and the partial lack of comparable indicators which lead to the development of objectives and indicators that respond to both national and international needs. Harmonization should be easier in view of the common goal, but policies and strategies do not always provide the required coherence.
\nThe presence of programmatic documents such as the Agenda 2030 reveals a path that can lead to good practices and reliable results even if they do not offer universal or global certainties. Politics at various levels play a decisive role and not always these take the best decisions regarding the rural environment. Thus, there is a diversity of situations, and the application of models is not necessarily a solution because of a wide spectrum of particular conditions at regional and local levels that must be taken into account. However, some mechanisms must be further developed to comply the international sustainable development perspectives to regional and local scales including rural areas.
\nAgenda 2030 relies on 17 sustainable development goals and 169 targets supported by the United Nations as a global effort to manage current challenges related to poverty, climate, environmental pollution, geographical inequalities, prosperity, peace, and justice [1]. This key strategic document continues the previous Eight Millennium Development Goals (started in 2000) committed to combat poverty, hunger, disease, and illiteracy, to promote gender equality and to ensure environmental sustainability until 2015 [2].
\nThe Paris Agreement aims to undertake ambitious efforts to combat climate change and adapt to its effects among developed and developing countries and to build future clean and climate-resilient communities [3]. The Paris Agreement and the Agenda 2030 are the most ambitious international initiatives so far which address major concerns related to future economic development perspectives combined with societal and environmental sustainability issues. Such actions must take into consideration the huge rural-urban gaps in terms of socioeconomic conditions and reveal the exposure of rural areas to current societal and environmental threats. Despite the rural-urban migration process, rural areas comprise vast geographical regions where a significant population still lives and faces emerging threats associated with climate change, poverty, and lack of critical infrastructure, particularly across developing and transition countries. Reducing geographical and socioeconomic inequalities in terms of basic needs must be a priority at international level. On the other hand, rural lands feed all basic needs of urban areas’ (raw materials, energy sources, food supply, water, etc.) additional labor force while preserving the natural habitats of endemic species (flora and fauna) and landscapes (e.g., protected areas). Rural settlements also contribute to the cultural and patrimonial heritage of each region and country. Therefore, sustainable rural development is a complex issue (environment-economic-social nexus) which must be further addressed with the same attention by academics, international bodies, national and local authorities, professionals, and members of civil society as for urban areas.
\nRural communities are facing several challenges in the context of climate change, land degradation, deforestation, biodiversity loss, and fragmentation of natural habitats, poverty, and geographical isolation. The rural population is more prone to extreme poverty, famine, social exclusion, and environmental injustice, particularly in developing countries from Africa, Asia, and Latin America. Rural communities depend on local geographical conditions (climate, natural resources, landscape, and geographical barriers, socioeconomic conditions, demographic features) to develop agricultural, industrial, or tourism activities as economic development pathways. A traditional economy based on subsistence agriculture is still widespread across rural regions of the globe. This type of economy is volatile to natural hazards (extreme weather, flash floods, landslides, erosion, drought) and poor agricultural productivity which translates into famine, extreme poverty, land abandonment, and massive migration. Land use management is a key factor for future rural development perspectives and to find the optimal equilibrium between natural habitats, agricultural lands, and built-up areas. Figure 1 reveals the emerging societal and environmental threats, sectoral approaches, and synergic effects that must be addressed at subnational levels by each country via regional and local authorities towards rural areas.
\nChallenges of rural communities under agenda 2030 framework.
Rural areas must cope with social, demographic, economic, governance, and environmental challenges. As an example, extensive cattle ranches and emerging oil palm cultivation threaten biodiversity conservation and food security across tropical rural regions while increasing social inequalities and conflicts [4]. On the other hand, agricultural land abandonment (associated with traditional farming, low productivity, poor infrastructure, aging population, massive migration, land ownership change, political instability) has created several socioeconomic and ecological dysfunctionalities in southeastern Europe [5].
\nPoor agricultural productivity in the Global South is related to the low use of improved seed, use of inappropriate fertilizer, inadequate irrigation, and lack of incentives for farmers in the absence of remunerative markets [6]. Extreme poverty, hunger, and undernourishment and rural depopulation are critical issues to be solved across rural Africa besides the poor access to critical amenities (health/education services, sanitation, and water facilities, energy) [7]. Climate changes, land fragmentation, natural resource depletion, political instability, corruption, and conflict areas will further threaten rural areas of developing countries.
\nIn this context, rural resilience and circular economy are key strategic directions to further develop rural economies and reduce socioeconomic inequalities and environmental injustice coupled with access to proper education. A linear economy based on “take-make-dispose” model feed by consumerism society is harmful for the environment and long-term sustainability of urban and rural areas. The EU is aware of the importance of shifting economic model from linear to an ambitious circular economy framework (https://ec.europa.eu/environment/circular-economy/index_en.htm) based on the 3Rs principles such as “reduce-reuse-recycle.”
\nThere are other activities which could be integrated resulting 6Rs policy such as the revaluation (of resources), redistribution (of income) and (improve) relations or 9Rs with another three Rs added such as resilience (adaptability), reassessment (scale value) and restructuring (of the economy) (source: https://www.activesustainability.com/sustainable-life/learnsustainability-the-3rs-6rs-and-9rs/).
\nThis new policy needs to be adopted by each EU country including rural areas of Eastern Europe. In countries like Romania, with over 2800 rural municipalities (communes) and other villages included in urban administrative areas, this transition from linear to circular economy could lead to new rural business opportunities based on responsible production and consumption of natural resources (organic farming, agritourism, local niche products, upcycling or creative reuse, etc.) while promoting local traditions and preserving the rural and natural landscapes. International cooperation is needed to successfully achieve the ambitious SDGs until 2030 at the global level. The development perspectives show some critical objectives which cannot be achieved without improvement of rural conditions across each continent.
\nPoverty and poor infrastructure are the main drivers for underdevelopment and environmental degradation. Rural settlements must have access to basic public utilities to ensure a decent quality of life in areas without significant geographical restrictions.
\nAt the global level, there are huge rural-urban gaps regarding population access to critical amenities such as drinking water, sanitation, electricity, and waste management services, particularly in low- and middle-income countries. Rapid urbanization in developing countries feeds rural-urban migration where poor people have crowed in slum areas without access to urban main public services threatening public health and local environment. Uncontrolled urban expansion towards surrounding rural lands leads to such informal settlements. There are 1.9 billion rural people without access to formal waste management services, and the coverage rate is under 50 among 105 countries [8]. This critical situation translates into million tons of household waste generated and uncollected each year, which leaks into the natural environment via wild dumps, waste dumping in water bodies, or open burning practices. Freshwater ecosystems are often affected by the uncontrolled disposal of waste which further contaminates the downstream water bodies through heavy rains and floods and finally reaches the marine environment. Wildlife is heavily exposed to plastic pollution where rural communities can contribute directly through fishing activities or indirectly as land-based sources via unsound waste management activities.
\nA study breaks down the rural infrastructure in China in three major categories: facilities for living and production (e.g., drinking water, irrigation, electricity, roads, wastewater treatment, and waste management), development infrastructure (education and healthcare), and environmental infrastructure (clean energy, green housing, and the environmental protection system) [9].
\nHowever, Figure 2 reveals a complex structure of public utilities as essential services for each rural municipality in the world. The lack or poor coverage of public utilities across rural regions leads to environmental degradation via air-water-soil nexus. These are essential services to maintain a decent standard of public health and to protect the natural environment against daily disturbances induced by human needs and economic activities.
\nPublic utilities as critical infrastructure for sustainable rural development.
The public utilities involve a multi-sectoral approach and a systemic perspective in adopting best current practices which will provide an easier transition to a diverse range of SDGs as shown in Figure 2. Thus, the improvement of such public services via sanitation facilities, water, and waste management, clean energy, road networks, and digital technologies will provide the base to build a sustainable development community.
\nIn nowadays, rural areas are still neglected by public services as in the case of former Soviet countries [10]. Furthermore, Central Asia is facing a growing urban-rural divide as a result of a capital city-centric growth model, economic nationalism, and water resource conflicts [11]. Additionally, rural depopulation of Russia makes more difficult to revitalize such regions, despite some recent efforts to improve population access to basic utilities [12]. Poor socioeconomic conditions in rural areas of new EU members stimulate the external migration (abroad) towards older EU countries, as in the case of Romania which facing is labor shortage. Distant rural settlements from urban areas are now facing such labor shortages combined with the aging population process. These peripheral regions lack critical amenities and have poor opportunities for economic development which still depend on traditional farming. Public investments in infrastructure and public utilities are crucial to reconnect such pockets of poverty areas to cities and emerging markets and, on the other hand, to mitigate the rural migration phenomenon.
\nImprovement of rural mobility by public transport network is essential for access to education (high schools, universities), healthcare services, justice, and social programs.
\nIn developed countries, there is a counter-urbanization process in the proximity of larger cities by movement of people to surrounding rural areas, avoiding noise and air pollution of core cities. There is an intense rural land reclamation for housing, transport, commercial, or industrial infrastructures around “peri-urban” areas including tourism and recreational activities. Therefore, the monopoly of farming activities is replaced by manufacturing, industrial, and various services close to larger urban areas where metropolitan regions emerge. However, this situation is in contrast with distant rural communities with primary focus in exploitation of natural resources and farming activities.
\nDespite the economic development in the latter years, China must manage several environmental challenges in rural areas such as [9] increasing waste generation rate with insufficient treatment capacity, crude and backward wastewater facilities, regional disparities in terms of sanitation services, and safe drinking-water sources’ issues. Similar challenges are facing Indonesia, where rural areas are poorly endowed with infrastructures like roads, sanitation, clean water, and energy [13]:
\nBiogas is a perfect solution for decentralized off-grid electricity situations in rural areas where an abundance of biowaste is available as feedstock; therefore, biogas could be used for cooking, heating, or gas lighting [14]. Anaerobic digestion is a proper solution to divert organic waste leaking into the natural environment towards an energy source (biogas) of fertilizer (digestate) for agricultural land. Animal feed and home composting practices are additional options to handle the organic waste produced at household level supporting organic farming and animal husbandry. Source separated of dry recyclables (metals, plastics, paper/cardboard, wood) would stimulate recycling and recovery practices via local small- and medium-sized enterprises (SMEs) enacting the first steps towards a rural recycling society.
\nRural communities must evaluate the exposure of its territory to natural hazards (floods, heavy rains, heatwaves, hail occurrence, drought, desertification, wildfire) and to take necessary measures to combat such threats. Poor population and peripheral rural areas are most vulnerable to climate change effects due to their reliance on subsistence agriculture.
\nRural population access to mobile phones and the Internet could improve agricultural productivity and better land use management practices based on updated knowledge. Also, digital technologies will help rural councils to reduce bureaucracy and increase transparency in community decisions. Better virtual connectivity to high-speed Internet services will provide new collaborative opportunities for rural entrepreneurs including women empowerment.
\nThe EU Cohesion Policy and Common Agricultural Policy (CAP) are two strategic initiatives which can help to reduce the geographical inequalities in Central and Eastern Europe in terms of basic infrastructure, promoting economic activity and agricultural development and improving the qualifications and skills of the inhabitants, particularly in rural areas [15]. However, the impact of such policies in case of new EU member states needs to be further adjusted with proper funding to boost local and regional economies. The gradual decline of fishery activities across EU rural coastal areas makes it difficult to revitalize these regions, despite new policy incentives such as the Common Fisheries Policy (CFP) as shown in case of Greece [16].
\nThe EU policies and financial instruments must accelerate the mitigation gap between western high-income countries and former Soviet countries of the Eastern Bloc where rural regions are regularly left behind. New projects like LiveRur (https://liverur.eu/) identify the innovative business models that are currently being developed in rural areas based on the sustainable mobilization of resources and better cooperation between operators along the value chain and lead to new services. At regional level, collective forest management supported by small-scale business projects could maintain the network of local produce markets with attractive esthetic values as well as biodiversity conservation [17].
\nThe role of small- and medium-sized enterprises in rural areas is based on local resource use, contributions to the local public budget, job creation, development of infrastructure, and engagement with community [18]. Furthermore, small-scale farmers using agroecological practices can produce the food necessary for diversified, nutritious, sustainable diets, while protecting environmental resources from further degradation [19]. Long-term growth policies should be reoriented to favor small farmers instead of big agribusiness players to maintain food security and social equity in tropical regions [4]. New urban-rural relations, in terms of organic food production, stimulate nearby farmers to adopt the best management practices and to develop nonfarming activities (e.g., tourism and recreational activities, environmental conservation, forest restoration) or urban-rural migration [20].
\nRural households that wish to market their products are restricted to local markets, or their production is sold at low prices to intermediaries [12]. This situation is specific to other Eastern European countries where the dispersion of villages, poor road networks, and the urban concentration of services are impediments in the development of direct linkages between local rural producers and urban customers. The development of farmer associations could be a solution in increasing access to regional or even national markets, to provide short supply chains and to reduce reliance on food product imports from abroad, particularly in countries with high potential in agricultural productivity like Romania. Such countries need to raise their rural economies from cheap raw material providers dedicated to exports towards manufactured products and services (e.g., furniture industry, food industry, organic farming, renewable energy, agritourism).
\nDigital technologies provide new ways to access price and market information, to coordinate input/output resources (including transport and logistics, finance, and production techniques) which could help the agriculture sector in the Global South as shown in several case studies [6].
\nImprovement of water harvesting, cultivating drought-resistant crops, ecological restoration, combined with better local governance, financial instruments, integrated resource management, sound public services, and better urban-rural linkages could help rural communities around the world to become more sustainable.
\nRemote rural areas of developing countries should rely on renewable energy sources due to poor coverage of electric grids, high costs of fuel transportation, unsuitable roads, and increasing consumption of biomass fuels with related pollution issues [21].
\nIn this context, “Smart Village” is a promising initiative to provide energy access to remote villages as a catalyst development route for other related sectors such as clean water, sanitation, education, healthcare, and gender equity and support the local markets and democratic engagement as stipulated by SDGs [22].
\nIn poor rural areas of developing countries like Bangladesh, where energy source is based on wood or dried cattle dung, the bioenergy systems (e.g., anaerobic digestion of biowaste) at household level could be a solution in achieving several SDGs [3, 4, 5, 7] with societal and environmental benefits despite of major challenges in implementing such projects at large scale associated with severe poverty, poor education, lack of awareness, social and cultural barriers, etc. [23]. Training activities and environmental awareness should combat such barriers, and fortunately, domestic biogas activities start to emerge in developing and transition countries across the globe such as Pakistan, India, China, Vietnam, Laos, Cambodia, Vietnam, Indonesia (Asia); Morocco, Algeria, Cote D‘Ivoire, Burkina Faso, Eritrea, Ethiopia, Kenya, Tanzania, Burundi, Rwanda, Uganda (Africa), Colombia, Peru, and Bolivia (South America) [14].
\nRural tourism, agritourism, religious tourism, and ecotourism are alternatives or complementary economic activities that could further stimulate rural entrepreneurship while decreasing rural community dependency on one main economic sector (agriculture, forestry, energy, mining, or fishing activities).
\nRural communities must respond to wide range of shocks (such as natural events, policy changes, economic disturbances, and insecurity), and successfully managing such risks increases the resilience of a rural community [24]. Sustainable development based on three basic pillars (social, economic, and environmental) could not be achieved without the proper education of the rural population.
\nThe literacy rate is directly proportional to development; thus, full access of rural communities to educational services should be regarded as starting point to achieve ambitious SDGs in developing countries. Also, rural-urban linkages must be addressed as a pathway to stimulate rural development perspectives. These rural-urban dependences may be positive, negative, or neutral. The positive ones are visible especially in developed countries, the negative ones especially in the less developed countries, but neutral relations are difficult to manage particularly in the proximity of urban areas. Regional convergence aims to reduce the geographical inequalities in the distribution of wealth between large cities, towns, and rural municipalities which are part of an administrative region or county. Such approach could strength the urban-rural relations in common projects regarding infrastructure, public services, mobility, business opportunities (e.g., start-up firms, employment growth) and tourism activities involving local stakeholders in community decisions.
\nThis chapter draws attention to the societal and environmental threats which rural communities around the world are facing. Agenda 2030 and SDGs aim to eradicate extreme poverty, famine, open defecation, and other critical issues in developing countries associated with lack of public utilities, mainly in rural areas, and to reduce the huge gaps between countries and regions. To achieve all range of SGDs across the globe, proper attention must be paid to rural development perspectives such as quality of life improvement, sustainable agriculture, rural resilience, and circular economy and reduced inequalities. Sustainable rural development involves a holistic approach where daily basic needs of rural populations must be covered by reliable public utilities combined with technical, socioeconomic, and environmental conditions to support regional economies and urban-rural linkages. Rural communities must develop several nonfarming activities coupled with agricultural systems (adapted to local geographical conditions) to become more resilient to economic shocks or environmental disturbances in the context of climate change. Rural areas should receive the same attention and opportunities from decision-makers, academics, and professionals regarding sustainable development policies and investments in infrastructure projects. Agenda 2030 could be achieved if sustainable rural development policies will be implemented in each country next to urban areas.
\nThe concept of negative pressure wound therapy (NPWT) was pioneered in 1997 by Morykwas, applying vacuum-assisted closure (VAC) on a pig wound model. Morykwas’ initial methodology involved packing the wound with foam, covering and sealing with an adhesive drape, and applying 125 mm Hg of negative pressure either continuously or intermittently [1]. The rudimentary NPWT led to increased blood f low, granulation tissue, and f lap survival, with decreased bacterial growth [1].
NPWT refers to wound healing technology consisting of three major parts: a wound dressing, covers, and a pump [2]. Wound dressing aids in transferring pressure from the pump to the wound itself, and modern NPWT typically utilizes reticulated open-pore polyurethane foam, intended to equalize the negative pressure across the entire wound surface [2]. The cover creates an airtight seal over an open wound, and the pump applies the negative pressure [2, 3].
There are four major types of NPWT [4]. The first is a large, battery-powered NPWT in the acute inpatient setting, while the second is a portable, battery-powered NPWT designed for outpatient use, but cannot be purchased over the counter and tends to be noisy [4]. The third type is a longer-lasting battery-powered NPWT that can be purchased over the counter and is designed to last 7 days and subsequently discarded, while altered models designed for inpatient use that include additional functions, such as negative pressure wound therapy with instillation-dwelling (NPWTi-d) and incisional negative pressure wound therapy (iNPWT), are the last [4].
By drawing f luid out of the wound, negative pressure increases blood f low, decreases the bacterial burden, cleans the wound, reduces local edema, and removes soluble inf lammatory mediators that may delay wound healing [2, 3, 4]. It has been postulated that NPWT draws antibiotics into the wound, but evidence is lacking [2]. The application of pressure applies forces to the wound, exerting effects macroscopically, through macrodeformation, as well as microscopically, through microdeformation [2, 5]. Naturally, negative pressure on a sealed wound draws the wound edges together [2]. However, it is important to note that the effect is reliant upon tissue parameters such as elasticity and tension, and the strength of the negative pressure does not seem to affect the amount of macrodeformation that occurs [2].
With NPWT, 5–20% of the wound surface experiences tissue stress, and by using a reticulated wound dressing, the action of drawing the wound bed into each pore via negative pressure constitutes the microdeformation that promotes tissue healing processes: increases in cell proliferation, angiogenesis, granulation tissue formation, and epithelialization and decreases in inf lammation [2, 5]. NPWT has the potential to grow granulation tissue over exposed bone, tendon, or devices [4]. Specifically, NPWT increases the concentration of VEGF, TGF-beta, FGF-2, PDGF, and IL-8 in the wound, with IL-10 increasing in the body, and decreased concentrations of TNF-alpha, IL-1 beta, and matrix metalloproteases (MMPs) [2]. In patients with type-2 diabetes, the pro-angiogenic and pro-epithelization proteins GDNF family receptor alpha-2 (GFRA2), which complement C1q binding protein (C1QBP), RAB35, and synaptic inositol 1,4,5-triphosphate 5-phosphatase 1 (SYNJ1), were increased [2].
Traditional NPWT has been utilized for chronic and acute open wounds and has become a mainstay of wound management [4, 6, 7].
Indications for NPWT are as follows [5, 8]:
Acute, chronic, and dehisced surgical wounds
Diabetic, pressure, and venous leg ulcers
Open abdominal wounds
Fasciotomies
Split-thickness skin graft (STSG) recipient sites
Flaps
Partial-thickness burns
Contraindications of NPWT include fistulas, malignancy, osteomyelitis, or infection, and NPWT should never be applied over exposed critical anatomic structures or in wounds with necrotic tissue [4, 5]. Despite the benefits of NPWT, there are several key reminders to remember in order for treatment to be effective. The cover and drainage tube must be assessed carefully as loss of seal or f luid buildup in the tube can lead to skin loss or maceration [5]. It is also important to monitor the pump to minimize the risk of exsanguination.
There is significant variability regarding the application of NPWT that depends on wound characteristics [2, 5]. The wound packing can be foam or gauze [2]. The pump may be mechanically or electrically driven [2]. The strength of negative pressure can vary from −50 mm Hg to −150 mm Hg [2]. The pattern of negative pressure application can be intermittent, continuous, or variable, with a continuous pattern the most common [2]. Selection of parameters is typically at the physician’s discretion, but a recommended pressure is 125 mm Hg applied in a pattern alternating between a 5-minute negative pressure and a 2-minute suction [4, 5]. Although studies suggest intermittent NPWT is the most effective pattern in inducing granulation tissue formation and increasing blood f low, it also increases pain for the patient [4, 5]. As a result, continuous pressure is often used for painful wounds, as well as wounds with overlying skin grafts, and particularly edematous wounds [5]. Beyond wound outcomes, NPWT reduces the number of dressing changes, healthcare labor, time spent in the hospital, and costs, and this is most demonstrated in portable NPWT, which allows treatment to be done at home [5, 9].
Beyond its indications listed previously, the use of NPWT has been expanding into newer wound types, including tunneling wounds and avascular tissue, and new published case series have demonstrated the use of NPWT in wounds such as necrotizing fasciitis [4, 5, 10]. Alterations to traditional NPWT led to negative wound pressure therapy with installation (NPWT-i) and incisional negative pressure wound therapy (iNPWT), the latter of which is utilized on closed wounds.
Incisional NPWT (iNPWT) has been used since 2006, as an adjunct treatment to augment wound healing and prevent surgical site infections (SSI) and wound complications.
Surgical incisions are a break in the skin and its defenses in avoiding translocation of infectious pathogens into the deeper tissues. It’s imperative to cover and isolate these incisions by a sterile protective dressing in the sterile environment of the operating room. Advances in these sterile protective dressings have taken place over decades and, in the present form, are made up of a nonadherent, antimicrobial-containing dressing covered with sterile gauze or abdominal pads, which are held in place by tapes or transparent film.
In the 1990s, NPWT demonstrated promising results in the management of acute and chronic open wounds, and Argenta and Morykwas proposed improved perfusion and wound contraction, which had a profoundly positive effect on the success of wound healing [1].
Gomoll et al., in 2006, pioneered the idea of incisional NPWT and described the application of NPWT on 35 orthopedic trauma patients, considered high-risk for infections [11]. A permeable nonadherent dressing was applied over the incision and covered with standard VAC sponge cut into 1-inch wide strips and then sealed with conventional VAC adhesive material. The negative pressure was maintained for 3 days, and patients were followed up for SSI for a minimum of 3 weeks. None of these 35 patients reported infections, which led to heightened interest in application of NPWT for surgical incisions.
Efficacy of NPWT depends on a number of factors, namely, foam width, foam thickness, magnitude of negative pressure, and its duration and frequency.
To achieve reproducible and standardized results, the NPWT dressing includes a skin interface layer, which is directly placed over the incision site, over which reticulated foam dressing is secured with occlusive drape. The VAC pump along with the canister is then connected via tubes attached through the foam dressing and secured underneath the occlusive drape to maintain an airtight seal. It’s imperative to secure and maintain an airtight seal, in order to achieve efficacy and prevent complications like maceration of peri-wound skin.
Several studies and trials have proposed these mechanisms of iNPWT (Figure 1):
Physical barrier to external contamination
Microdeformation of the wound edges and release of local growth factors
Approximation of wound edges and minimizing lateral tension and dead space
Fluid egress and exudate removal
Cross-sectional depiction of an incision closed with sutures without incisional NPWT (a). Application of incisional NPWT decreases lateral tissue tension and increases incisional apposition (b), reducing dead space. The applied pressure causes microdeformation and release of local growth factors, promoting healing of the surgical incision (reprinted with permission from Ref. [
The negative pressure is commonly used
Another alternative, to bridge the gap between continuous and interrupted pressure, is
The role of foam width and thickness is important, as it’s proportional to the lateral tension attenuation, as described later in the chapter. Hence, a standard foam width of 60 mm is recommended. Cutting thin strips of the foam and using as a construction dressing are also discouraged, as it limits the efficacy and benefits of the iNPWT.
The optimum negative pressure has been a debatable aspect of NPWT. A lot of research focused on negative pressure of −80 mm Hg with positive results, followed by a paper published by Morykwas et al., using −125 mm Hg. The results of this trial were promising as it demonstrated improved healing and granulation as compared to the earlier results published by the same team and others. Recent literature and guidelines recommend a pressure of −125 mm Hg; however, pressures ranging from −80, −100, and −125 mm Hg have been employed, and encouraging results have been published.
Application of iNPWT on perineal wounds, following abdominoperineal resection (APR) for colonic and anal lesions, demonstrated improved wound healing and reduced complications and infection rates, while using pressure of −80 mm Hg. The increase in negative pressure beyond −125 mm Hg does not demonstrate improved wound outcomes, either in open or closed wounds.
As the uses and application of the NPWT system develop for closed incision surgical wounds, results of various large-scale clinical trials would emerge, and further modifications would evolve to maximize the clinical benefits of this promising therapeutic modality for postoperative surgical wounds.
Several studies have described the benefits of incisional NPWT (iNPWT) in general, colorectal, cardiac, vascular, plastic, and orthopedic surgeries. These benefits have been classified as immediate, intermediate, and long-term effects and result from the sterile isolation of the incision; mechanical stabilization and reduction in the tensile forces; obliteration of dead space; reduction of local edema, hematoma, and seroma; and increased perfusion and lymphatic f low.
Nam et al. proposed benefits of iNPWT [12], as
Immediate effects
Protection of incision from external contamination
Decreased lateral tension on the incision
Increased appositional strength
Normalized stress distribution
Increased skin perfusion
Intermediate effects
Decreased edema
Decreased hematoma/seroma formation
Increased lymphatic f low
Long-term effects
Improved Incision quality
Mechanical strength
Histology
Gene expression
Surgical site infections (SSIs) result in significant morbidity and increased healthcare costs, accounting for 21.8% of the 721,800 healthcare-associated infections recorded annually in the United States [13].
SSIs are estimated to increase average hospital stay by 9.6 days, resulting in an added cost of $38,656 and around $10 billion in direct and indirect costs annually [14].
With emphasis on lowering healthcare costs and advancing quality of care, SSIs pose a major physical, psychological, and economic burden.
Incisional NPWT immediately provides protection and isolation of the incision from external contamination. Multiple studies in trauma surgery, general surgery, and plastic surgery have attributed decreased local edema, f luid egress, lower hematoma/seroma rates, lower time to healing, and improved genomic profile, in terms of reduction of pro-inf lammatory cytokines and chemokines in surgical incisions covered with NPWT. An international expert panel in 2017 recommended ciNPWT for patients at high risk for surgical site complications [15]. Notable high-risk features include diabetes, ASA score ≥ 3, obesity (BMI ≥ 30 kg/m2), tobacco use, hypoalbuminemia, corticosteroid use, high-tension wounds and revision surgery.
Multiple studies across different specialties reported a threefold to fivefold reduction in the surgical site infection risk, following the use of ciNPWT [16, 17, 18].
Notably, Grauhan and team reported findings of a prospective study of 150 obese patients who underwent cardiac surgery via a median sternotomy. A significant reduction of fourfold in the incidence of wound infection was seen in the iNPWT group compared to conventional dressings, at 1 week of surgery [19]. Similar findings were reported by Matatov in groin infections covered with iNPWT, after vascular procedures (6 vs. 30%, p = 0.0011) [20]. Bonds described a reduction in the rate of SSIs in the iNPWT group, after open colectomy (12.5 vs. 29.3%, p < 0.05) [21].
Contrastingly, a study analyzing 398 patients concluded incisional NPWT improved short-term wound complications but had no effect on long-term infection rate following knee and hip arthroplasty. A higher proportion of iNPWT patients reported wound drainage at day 7, though similar increase was not seen at different time intervals. This study is the largest RCT comparing outcomes of NPWT dressing in elective lower extremity arthroplasty and supporting improved soft tissue healing response and lower wound-related complications, but no effect on the risk of late superficial or deep infections [22].
Evidence supporting the use of iNPWT in hand and spine surgery is new and fewer. SSIs occur is 0.4–20% of patients undergoing spine surgery and contribute to increased morbidity, hospitalization, and costs [23, 24, 25, 26]. Various treatment modalities such as drains, copious irrigation, and prophylactic antibiotics are employed. Adogwa et al. reported a 30% reduction in wound infection rate and 50% reduction in wound dehiscence rates in patients after long-segment thoracolumbar spine fusion and suggested ciNPWT as a safe and effective means of wound management for high-risk spine incisions.
Recent literature suggests incisional NPWT as a safe and effective method in preventing SSIs and wound complications in high-risk patients.
As modern healthcare strives to deliver quality and efficient yet cost-effective care, continued efforts are warranted to evaluate economic viability of NPWT use and its application in various specialties.
An estimated cost of $100 per day was associated with the use of the PREVENA (V.A.C therapy, KCI, San Antonio, TX) system, which showed significant reduction in SSI risk [27]. With a typical use of 5–7 days, cost of ciNPWT is estimated around $500–700. When used in high-risk populations and higher-cost wound management modality, such additional costs of the NPWT system are validated, as they lead to overall reduction in total healthcare expenditure. SSIs prolong hospital stay, on an average of 9 days, and are associated with an increase in costs up to $20,000 [28].
When compared with indirect costs associated with treatment of wound dehiscence and complications, and direct costs such as daily dressing changes, the economic viability of the iNPWT system in high-risk population seems justified. Chopra et al. found an estimated cost saving of $1456 with ciNPWT use in abdominal wall surgeries. Raymund Horch and his team proposed a cost saving of $163 in obese patients and $203 in morbidly obese patients employing iNPWT in post-bariatric patients undergoing abdominal and thigh dermolipectomy. The authors determined that a 28 and 25% reduction in SSIs’ rate in the obese and morbidly obese patients, respectively, was needed to achieve cost savings with iNPWT. Lewis et al. proposed cost savings with iNPWT if wound complications are reduced by one-third in patients undergoing laparotomy for gynecological malignancies [29]. Further evaluation of the applicability of the NPWT system and its costs is warranted in diverse patient population (high vs. low risk), healthcare setups (inpatient vs. at-home), and specialties.
NPWT has been applied successfully as a therapeutic modality to treat open wounds for decades, which led to heightened interest in the scientific community to use it over closed wounds, incisions, and skin grafts. Many trials and studies have proposed the following mechanisms of incisional NPWT:
Foam dressing protects wound from external mechanical stress.
Decrease wound tension and tensile forces in deeper dermal layers.
Continuous removal of exudate and f luids.
Decrease local edema improving physiologic adaptation of the wound.
Increase in local perfusion, oxygenation, and lymphatic f low.
Decrease hematoma/seroma rates.
Decrease in time-to-heal duration.
On a molecular level, iNPWT has been hypothesized to remove toxic inf lammatory mediators and increase the concentration of local tissue growth factors, via microdeformation [30].
An immediate benefit of the iNPWT is the foam dressing that protects the incision/wound from external contamination as well as its ability to minimize the lateral tension around the suture line by 50%. It also normalizes tensile forces in the deep dermal tissue to decrease dead space, which aids in wound healing and reduced seroma/hematoma rates. In wound mechanics, study conducted on an incision made on silicon surface found when iNPWT was applied, 51% more force was required to pull apart a sutured incision, and 43% more force was required to pull apart a stapled incision than non-iNPWT-treated incisions. An interesting correlation was the proportional association between the width of the foam dressing and the force required to pull the incision apart. The study concluded that a foam width of 60 mm is required to increase the tensile strength of the incision.
Studies on earlier techniques of NPWT discouraged the construction method (dressing of the incision by cutting foam into thin strips) as it likely decreased the positive effect of reduced lateral tension on the incision [1].
Early application of iNPWT on pig wound model demonstrated improved healing in terms of mechanical, histomorphometric, and gene expression properties. These incisions showed significantly improved mechanical properties (strain energy density, peak strain) and a narrower scar, extending in the deep dermis [31].
Long-term genomic analysis on surgical wounds reveals pro-inf lammatory chemokine and cytokine signals in conventional dressing (sterile absorbent abdominal dressing)-treated incisions compared to iNPWT-treated incisions. Thus, the latter seemed superior in wound strength and wound maturity compared to conventional dressing-covered incisions [31].
Early application of iNPWT promotes f luid egress and continuous removal of exudates. This leads to reduction in local edema, reduced hematoma/seroma rates, improved time to hematoma resolution, decreased time to wound healing, and with split-thickness skin grafts (STSG), improved survival with NPWT [12]. When used with grafts and skin substitutes, the f luid egress with iNPWT minimizes sheer stress and provides tight apposition to the underlying recipient wound bed, which promotes incorporation of the graft or skin substitutes and reepithelialization of graft interstices [32, 33, 34]. Maruccia et al. described faster healing, fewer dressing changes, and quicker maturity of mesh skin grafts when combined with NPWT. This combined treatment provides higher integration, better immobilization of the graft, expulsion of f luids, and a moist clean wound bed [35].
The reduction in local edema and removal of f luids in sites such as the abdomen and breast help in reducing the need for postoperative drainage. There is renewed interest in analyzing results to conclude reduced need and duration for postoperative drains. Several studies in general surgery, plastic surgery, and orthopedic surgery have demonstrated reduced drainage with iNPWT-covered incisions. Raymund Horch and his team, in 2014, demonstrated the benefits of iNPWT in a post-bariatric patient population undergoing dermolipectomy of the abdomen and who presented with reduced exudate formation, earlier drain removal, and decreased length of hospitalization [36].
Pain relief with iNPWT has been reported rarely, as very few studies have focused on reporting pain scores with this modality. Maruccia et al., in 2016, reported a statistically significant reduction in pain scores and wound area in skin graft patients. This could be explained by faster healing and improved uptake of the graft, along with less frequent need for dressing changes [35].
Recent literature shows
An important aspect of iNPWT is its ability to alter
Timmers et al. found a fivefold increase in perfusion, assessed with Doppler probes, after application of NPWT over the forearms of healthy volunteers [38].
In a study on iNPWT published in 2016 from the University of Chicago, comprising of 228 patients undergoing immediate expander-based breast reconstruction (study and control groups of 45 and 183, respectively), it was concluded that the application of iNPWT significantly decreased the rate of major mastectomy f lap necrosis rate (requiring operative intervention), overall mastectomy f lap necrosis rates, and overall complication rates [39].
An important supplement to the improved perfusion is
Kilpadi and Cunningham reported 63% reduced hematoma/seroma rates with iNPWT and injected isotope-labeled nanospheres in the subcutaneous tissue to discover their highest concentration in lymph nodes closest to, draining the incision site [40]. Recent literature is overwhelmingly in favor of reduced seroma/hematoma rates, across various surgical procedures covering different surgical specialties and incision sites. To name a few, iNPWT and reduced seroma/hematoma have been demonstrated at f lap donor sites, like scapular and latissimus dorsi free f lap harvest sites, total hip and knee arthroplasty, over abdominal (e.g., cesarean, laparotomy, and abdominoplasty), thoracic incisions (e.g., sternotomy), breast incisions (expander-based and autologous reconstruction), lower extremity (trauma and fractures), and groin incisions (vascular procedures involving femoral vessels) [40, 41, 42, 43].
Reduced hospital stay with iNPWT use has been demonstrated extensively, via reduced time-to-heal duration, as well as decreased SSI and wound dehiscence and complication rates. A recent systematic review on abdomen procedures estimates reduction of ICU stay but required more extensive clinical RCT and research [44]. Though, it’s difficult to quantify this reduction in hospital stay across various procedures, NPWT as an incision management tool has been demonstrated to optimize and accentuate the wound healing process.
These rates have been assessed in a recent meta-analysis comparing efficacy of NPWT in high-risk patients undergoing abdominal wall reconstruction. Both outcomes were low in the iNPWT group as compared to control [9 vs. 14% and 3 vs. 14%, respectively; RR = 0.68 CI (0.46–0.99)].
Wound dehiscence and complications are lowered with the use of iNPWT and its aforementioned benefits. Recent literature estimates a reduction of ~50% reduction in wound dehiscence rates, across various surgical specialties [23, 45, 46, 47, 48, 49, 50].
The proposed mechanism of improved wound healing, increased perfusion, decreased infection rates, decreased hematoma/seroma rates, decreased lateral and deep wound tension, improved wound maturity, and strength and obliteration of dead space augurs well for low wound dehiscence and complication rate.
Besides the cost-benefit analysis, an incision management tool with these benefits and improved scar appearance definitely requires further clinical trials and recommendations for use, especially in high-risk patients.
Interest in the use of iNPWT has been peaking in the last few years as favorable outcomes seem promising and with easy adaptability and application of at-home single-use canister-based NPWT. This single-use NPWT can be used for 7 days and improves patient acceptability and compliance. A lot of research has been invested in the safety of these systems and to identify complications impeding its widespread use.
The risk of hemorrhage, especially in patients on anticoagulants and with clotting disorders, has been described with the use of iNPWT. Any evidence of fistulas or communication to visceral cavities needs further imaging and management before the application of negative pressure. Allergic reaction to the dressings is a contraindication to the use of iNPWT. Minor skin irritation and ecchymosis are the most frequently encountered complications.
The earliest description of the use of negative pressure in wound healing was in the management of soft tissue injury associated with open fractures. The beneficial outcomes seen in various animal models spurred the development of a wide range of clinical indications including abdominal, breast, orthopedic, vascular, cardiac, and plastic surgeries (e.g., skin graft, burns, muscle f lap) [51].
The use of incisional NPWT in high-risk patients undergoing abdominal surgeries decreased wound complications such as surgical site infections and wound healing complications. The primary goals of incisional NPWT wound management include active removal of exudates, estimation of third-space f luid loss, and avoidance of mechanical contamination of the abdominal viscera [51].
With the help of the dressing, NPWT applies negative pressure uniformly, thus promoting healing by reducing edema, approximating the wound, and removing infectious material and exudates [52].
Some studies showed that NPWT improves the removal of abdominal f luid, which helps in early fascial closure. The removal of f luids is especially beneficial in reducing inf lammatory responses that may occur [53, 54]. This is supported by the septic/hemorrhagic shock porcine model, which showed that NPWT efficacy was partially due to a reduction in the anti-inf lammatory response [55].
On a recent comparative study on incisional NPWT and conventional dressing following abdominal wall reconstruction, the authors demonstrated a statically significant reduction in the incidence of skin dehiscence and overall wound complications in the incisional NPWT group compared with the conventional dressing group [30].
In a study comparing the rates of SSI of patients who underwent surgery for pancreatic, colorectal, or peritoneal surface malignancies between incisional NPWT and conventional dressings, the incidence of SSI was significantly lower in the incisional NPWT group than the conventional group [56].
The use of incisional NPWT as an effective prophylactic tool has been examined in studies from various surgical specialties. The results show that its use facilitates healing of incisional wounds and reduces the incidence of wound healing disorders [57].
Breast reconstruction using the expander-/implant-based breast reconstruction is usually performed after mastectomy and plays a crucial role in psychosocial and oncological outcomes in breast cancer patients.
One of the most common and significant complications in the immediate expander-based breast reconstruction is mastectomy f lap necrosis, which has been reported to occur in up to 30% of the patients [58]. Authors of a recent study evaluated the incidence of mastectomy f lap necrosis in patients with incisional NPWT after immediate expander-based breast reconstruction compared with the incidence in patients with conventional dressing.
The incisional NPWT group had a lower overall complication rate, overall mastectomy f lap necrosis rate, and major mastectomy f lap necrosis than the conventional dressing group [59].
Besides oncological breast surgery, the use of incisional NPWT was also assessed in a multicenter study on reduction mammoplasty. The results have shown that incisional NPWT applied to closed incision appeared to be most effective on dehiscence in the higher BMI categories and benefit most in preventing complications in the higher tissue resection weight categories [60] (Figure 2). The results thus suggest applying incisional NPWT devices in reduction mammoplasty where the BMI is over 25 or resection weight is above 500 mg [60] (Figure 3).
Progression of incisions in patient treated with iNPWT and standard wound care after bilateral reduction mammaplasty. Wound complications and dehiscence are reduced with iNPWT (reprinted with permission from Ref. [
Relation of body mass index (BMI) on wound dehiscence rates in patients undergoing reduction mammaplasty. The NPWT group shows lower wound dehiscence rates than standard wound care (reprinted with permission from Ref. [
The safety and efficacy of incisional NPWT in elderly patients undergoing breast surgery were studied previously. The results of the study suggest that the rates of infections and surgical site events (SSE) were lower with the use of incisional NPWT. The use of incisional NPWT is thus highly recommended in elderly patients, who have significant increased risk of developing SSE when compared with younger patients [61]. Other studies have concluded that incisional NPWT applied to closed surgical incisions on healthy patients after breast reduction surgery prevented postsurgical wound complications significantly [62].
Complications related to high-risk lower extremity fractures such as calcaneal, pilon, and tibial plateau are particularly common. Common complications include infection and wound healing problems. In a prospective randomized multicenter clinical trial evaluating the use of NPWT after calcaneus, pilon, or tibial fractures, the authors have found a significant reduction of infection in the NPWT group [48]. The beneficial effects of NPWT on wounds after total ankle replacement or calcaneus fractures were recognized in a study that showed decreased total time required to achieve complete healing, decreased risk of infections, and decreased pain and swelling [63]. Several retrospective studies showed positive effects of incisional NPWT on wounds after open reduction and internal fixation of acetabular fractures. The NPWT group showed reduced rates of wound dehiscence, deep wound infections, and infection rates [64, 65].
A prospective randomized clinical study examined the wounds of patients after total hip arthroplasty using ultrasound examination to evaluate for the development of potential seroma, a possible risk factor for wound infections. The study showed a significant reduction in the seroma size when compared to standard wound dressing and positive effects on wound healing and complication rate [42].
Despite the use of prophylactic antibiotics, the increasing incidence of postoperative sternal wound infections continues to be a serious problem after surgical cardiac procedures. Sternal wound infections are associated with additional expenses, increased length of stay in the hospital, increased mortality during the first year, and a significant reduction in quality of life [66].
Risk factors that increase the risk of sternal wound infections include smoking, diabetes, increasing number of grafts, peripheral vascular disease, chronic pulmonary disease, obesity, increased duration of mechanical ventilation, preoperative malnutrition, and harvesting of bilateral internal mammary arteries [67].
The use of incisional NPWT on sternal surgical incisions in patients with multiple comorbidities and consequently a high risk for wound complications was evaluated. Results have shown no wound complications in this high-risk group of patients at least 30 days after surgery and complete wound and surrounding skin healing with the absence of skin lesion due to negative pressure after removal of the dressing [68]. Results from another study also concluded that applying incisional NPWT over clean, closed incisions for the first 6–7 postoperative days reduced the likelihood of postoperative wound infections after median sternotomy not only in high-risk patients but also in a comprehensive patient population [45].
Vascular surgical site infections (SSI) occur as a result of perioperative events that lead to the colonization of the wound and underlying graft with bacterial species. Patients undergoing vascular procedures are at an increased risk of developing an SSI of up to 5% of clean procedures and 30% of clean-contaminated procedures [69]. Severe complications that arise after vascular surgery including leg amputation and death prompted the use of incisional NPWT postoperatively to prevent complications associated with such surgeries. Results of different studies have shown a potential reduction in wound complications and no observed increase in hemorrhage in high-risk patients with severe comorbidities undergoing vascular surgeries [70].
Recent retrospective study on lower leg fasciotomy supports faster wound closure and daily wound size reduction, fewer dressing changes, and shorter hospital stay with NPWT. These factors contribute to significant reduction in surgical site infections, from 30 per cent with standard wound care to 6 per cent with closed incisional NPWT [71].
In plastic surgery, the use of NPWT is particularly important in patients who experienced complications associated with skin graft rejection and its associated partial necrosis. It’s also used after excision of large scalp f laps due to injuries and lack of opportunities to cover it with the patient’s own skin. NPWT resulted in faster healing and granulation of wounds and a reduction of the overall size [72]. The use of NPWT in large wound surfaces with large amounts of mucus, observed in skin burns, resulted in a significant acceleration in the time taken for patients’ healing and rehabilitation. Additional outcomes included wounds that healed better, fewer infection rates, and more elastic tissue preservation [73]. Results from a multicenter, prospective randomized controlled, within-patient study involving our center and senior author (RDG) provided high-level evidence supporting significantly reduced wound complications following application of iNPWT in susceptible patients [60].
Advances in surgical and sterilization techniques have largely mitigated risk of wound complications and SSI rates; however, these complications till date pose a major physical, financial, and psychological challenge in the postoperative phase of treatment. Incisional NPWT presents a promising treatment modality for surgical wounds and incisions, with its proposed benefits in reducing infections, preventing wound dehiscence and optimizing wound healing and scarring. Randomized controlled trials and further clinical research are warranted to develop guidelines to the safe, effective, and routine use of iNPWT. However, in the present economic model of healthcare, efficacy of a treatment modality alone does not justify its use, and a large-scale cost-benefit analysis is warranted to rationalize its use in high-risk and low-risk postoperative patients.
The authors would like to thank Abbas Hassan, Rou Wan, and Dr. Jing Liu for their valuable inputs and contribution.
The authors declare no conf lict of interest.
The first author CJJ would like to immensely thank senior author RDG for his unending support, guidance, and inspiration to strive to be perfect.
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Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9669",title:"Recent Advances in Rice Research",subtitle:null,isOpenForSubmission:!1,hash:"12b06cc73e89af1e104399321cc16a75",slug:"recent-advances-in-rice-research",bookSignature:"Mahmood-ur- Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9669.jpg",editedByType:"Edited by",editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9711",title:"Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production",subtitle:null,isOpenForSubmission:!1,hash:"12cf675f1e433135dd5bf5df7cec124f",slug:"pests-weeds-and-diseases-in-agricultural-crop-and-animal-husbandry-production",bookSignature:"Dimitrios Kontogiannatos, Anna Kourti and Kassio Ferreira Mendes",coverURL:"https://cdn.intechopen.com/books/images_new/9711.jpg",editedByType:"Edited by",editors:[{id:"196691",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Kontogiannatos",slug:"dimitrios-kontogiannatos",fullName:"Dimitrios Kontogiannatos"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10134",title:"Organic Agriculture",subtitle:null,isOpenForSubmission:!1,hash:"a9866f9df52191cc505b27fb2abdc687",slug:"organic-agriculture",bookSignature:"Shaon Kumar Das",coverURL:"https://cdn.intechopen.com/books/images_new/10134.jpg",editedByType:"Edited by",editors:[{id:"182210",title:"Dr.",name:"Shaon Kumar",middleName:null,surname:"Das",slug:"shaon-kumar-das",fullName:"Shaon Kumar Das"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9712",title:"Genetic Transformation in Crops",subtitle:null,isOpenForSubmission:!1,hash:"c111fe32d4d7e3988e4ef2fd6775a265",slug:"genetic-transformation-in-crops",bookSignature:"Kin-Ying To",coverURL:"https://cdn.intechopen.com/books/images_new/9712.jpg",editedByType:"Edited by",editors:[{id:"310646",title:"Dr.",name:"Kin-Ying",middleName:null,surname:"To",slug:"kin-ying-to",fullName:"Kin-Ying To"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8153",title:"Agronomy",subtitle:"Climate Change & Food Security",isOpenForSubmission:!1,hash:"2c01368bbeacbbedeb3681ea0c037dbe",slug:"agronomy-climate-change-food-security",bookSignature:"Amanullah",coverURL:"https://cdn.intechopen.com/books/images_new/8153.jpg",editedByType:"Edited by",editors:[{id:"178825",title:"Dr.",name:"Dr.",middleName:null,surname:"Amanullah",slug:"dr.-amanullah",fullName:"Dr. Amanullah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:54,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"40178",doi:"10.5772/52583",title:"Molecular Markers and Marker-Assisted Breeding in Plants",slug:"molecular-markers-and-marker-assisted-breeding-in-plants",totalDownloads:23030,totalCrossrefCites:81,totalDimensionsCites:146,abstract:null,book:{id:"3060",slug:"plant-breeding-from-laboratories-to-fields",title:"Plant Breeding from Laboratories to Fields",fullTitle:"Plant Breeding from Laboratories to Fields"},signatures:"Guo-Liang Jiang",authors:[{id:"158810",title:"Dr.",name:"Guo-Liang",middleName:null,surname:"Jiang",slug:"guo-liang-jiang",fullName:"Guo-Liang Jiang"}]},{id:"33765",doi:"10.5772/37578",title:"Nutrient Solutions for Hydroponic Systems",slug:"nutrient-solutions-for-hydroponic-systems",totalDownloads:71704,totalCrossrefCites:11,totalDimensionsCites:66,abstract:null,book:{id:"1781",slug:"hydroponics-a-standard-methodology-for-plant-biological-researches",title:"Hydroponics",fullTitle:"Hydroponics - A Standard Methodology for Plant Biological Researches"},signatures:"Libia I. Trejo-Téllez and Fernando C. Gómez-Merino",authors:[{id:"113365",title:"Dr.",name:"Libia I.",middleName:null,surname:"Trejo-Téllez",slug:"libia-i.-trejo-tellez",fullName:"Libia I. Trejo-Téllez"},{id:"113414",title:"Dr.",name:"Fernando C.",middleName:null,surname:"Gómez-Merino",slug:"fernando-c.-gomez-merino",fullName:"Fernando C. Gómez-Merino"}]},{id:"45745",doi:"10.5772/56824",title:"Current Advances on Genetic Resistance to Rice Blast Disease",slug:"current-advances-on-genetic-resistance-to-rice-blast-disease",totalDownloads:4528,totalCrossrefCites:27,totalDimensionsCites:58,abstract:null,book:{id:"3554",slug:"rice-germplasm-genetics-and-improvement",title:"Rice",fullTitle:"Rice - Germplasm, Genetics and Improvement"},signatures:"Xueyan Wang, Seonghee Lee, Jichun Wang, Jianbing Ma, Tracy\nBianco and Yulin Jia",authors:[{id:"168971",title:"Dr.",name:"Yulin",middleName:null,surname:"Jia",slug:"yulin-jia",fullName:"Yulin Jia"}]},{id:"68945",doi:"10.5772/intechopen.88434",title:"Effect of Abiotic Stress on Crops",slug:"effect-of-abiotic-stress-on-crops",totalDownloads:1494,totalCrossrefCites:28,totalDimensionsCites:46,abstract:"Crop yield is mainly influenced by climatic factors, agronomic factors, pests and nutrient availability in the soil. Stress is any adverse environmental condition that hampers proper growth of plant. Abiotic stress creates adverse effect on multiple procedures of morphology, biochemistry and physiology that are directly connected with growth and yield of plant. Abiotic stress are quantitative trait hence genes linked to these traits can be identified and used to select desirable alleles responsible for tolerance in plant. Plants can initiate a number of molecular, cellular and physiological modifications to react to and adapt to abiotic stress. Crop productivity is significantly affected by drought, salinity and cold. Abiotic stress reduce water availability to plant roots by increasing water soluble salts in soil and plants suffer from increased osmotic pressure outside the root. Physiological changes include lowering of leaf osmotic potential, water potential and relative water content, creation of nutritional imbalance, enhancing relative stress injury or one or more combination of these factors. Morphological and biochemical changes include changes in root and shoot length, number of leaves, secondary metabolite (glycine betaine, proline, MDA, abscisic acid) accumulation in plant, source and sink ratio. Proposed chapter will concentrate on enhancing plant response to abiotic stress and contemporary breeding application to increasing stress tolerance.",book:{id:"9345",slug:"sustainable-crop-production",title:"Sustainable Crop Production",fullTitle:"Sustainable Crop Production"},signatures:"Summy Yadav, Payal Modi, Akanksha Dave, Akdasbanu Vijapura, Disha Patel and Mohini Patel",authors:[{id:"186963",title:"Dr.",name:"Summy",middleName:null,surname:"Yadav",slug:"summy-yadav",fullName:"Summy Yadav"},{id:"308004",title:"Ms.",name:"Payal",middleName:null,surname:"Modi",slug:"payal-modi",fullName:"Payal Modi"},{id:"308005",title:"Ms.",name:"Akanksha",middleName:null,surname:"Dave",slug:"akanksha-dave",fullName:"Akanksha Dave"},{id:"308006",title:"Ms.",name:"Akdasbanu",middleName:null,surname:"Vijapara",slug:"akdasbanu-vijapara",fullName:"Akdasbanu Vijapara"},{id:"308007",title:"Ms.",name:"Disha",middleName:null,surname:"Patel",slug:"disha-patel",fullName:"Disha Patel"},{id:"308008",title:"Ms.",name:"Mohini",middleName:null,surname:"Patel",slug:"mohini-patel",fullName:"Mohini Patel"}]},{id:"45540",doi:"10.5772/56621",title:"Genes and QTLs for Rice Grain Quality Improvement",slug:"genes-and-qtls-for-rice-grain-quality-improvement",totalDownloads:3737,totalCrossrefCites:21,totalDimensionsCites:46,abstract:null,book:{id:"3554",slug:"rice-germplasm-genetics-and-improvement",title:"Rice",fullTitle:"Rice - Germplasm, Genetics and Improvement"},signatures:"Jinsong Bao",authors:[{id:"52135",title:"Dr.",name:"Jinsong",middleName:null,surname:"Bao",slug:"jinsong-bao",fullName:"Jinsong Bao"}]}],mostDownloadedChaptersLast30Days:[{id:"70658",title:"Factors Affecting Yield of Crops",slug:"factors-affecting-yield-of-crops",totalDownloads:4044,totalCrossrefCites:25,totalDimensionsCites:40,abstract:"A good understanding of dynamics involved in food production is critical for the improvement of food security. It has been demonstrated that an increase in crop yields significantly reduces poverty. Yield, the mass of harvest crop product in a specific area, is influenced by several factors. These factors are grouped in three basic categories known as technological (agricultural practices, managerial decision, etc.), biological (diseases, insects, pests, weeds) and environmental (climatic condition, soil fertility, topography, water quality, etc.). These factors account for yield differences from one region to another worldwide. The current chapter will discuss each of these three basic factors as well as providing some recommendations for overcoming them. In addition, it will provide the importance of climate-smart agriculture in the increase of crop yields while facilitating the achievement of crop production in safe environment. This goes in line with the second goal of 2030 Agenda for Sustainable Development of United Nations in transforming our world formulated as end hunger, achieve food security, improve nutrition and promote sustainable agriculture.",book:{id:"8153",slug:"agronomy-climate-change-food-security",title:"Agronomy",fullTitle:"Agronomy - Climate Change & Food Security"},signatures:"Tandzi Ngoune Liliane and Mutengwa Shelton Charles",authors:[{id:"313819",title:"Dr.",name:"Liliane",middleName:null,surname:"Tandzi",slug:"liliane-tandzi",fullName:"Liliane Tandzi"},{id:"314316",title:"Prof.",name:"Charles Shelton",middleName:null,surname:"Mutengwa",slug:"charles-shelton-mutengwa",fullName:"Charles Shelton Mutengwa"}]},{id:"40178",title:"Molecular Markers and Marker-Assisted Breeding in Plants",slug:"molecular-markers-and-marker-assisted-breeding-in-plants",totalDownloads:23030,totalCrossrefCites:81,totalDimensionsCites:146,abstract:null,book:{id:"3060",slug:"plant-breeding-from-laboratories-to-fields",title:"Plant Breeding from Laboratories to Fields",fullTitle:"Plant Breeding from Laboratories to Fields"},signatures:"Guo-Liang Jiang",authors:[{id:"158810",title:"Dr.",name:"Guo-Liang",middleName:null,surname:"Jiang",slug:"guo-liang-jiang",fullName:"Guo-Liang Jiang"}]},{id:"60074",title:"Pollen Germination in vitro",slug:"pollen-germination-in-vitro",totalDownloads:2759,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Pollen germination in vitro is a reliable method to test the pollen viability. It also addresses many basic questions in sexual reproduction and particularly useful in wide hybridization. Many pollen germination medium ranging from simple sugars to complex one having vitamins, growth regulators, etc. in addition to various minerals have been standardized to germinate pollen artificially. The different media, successful pollen germination methods, procedures from pollen germination studies with wheat, rye, brinjal, pigeonpea and its wild relatives are discussed.",book:{id:"6659",slug:"pollination-in-plants",title:"Pollination in Plants",fullTitle:"Pollination in Plants"},signatures:"Jayaprakash P",authors:[{id:"235465",title:"Dr.",name:"Jayaprakash",middleName:null,surname:"P",slug:"jayaprakash-p",fullName:"Jayaprakash P"}]},{id:"62376",title:"Genotype × Environment Interaction: A Prerequisite for Tomato Variety Development",slug:"genotype-environment-interaction-a-prerequisite-for-tomato-variety-development",totalDownloads:2297,totalCrossrefCites:1,totalDimensionsCites:6,abstract:"Tomato (Solanum lycopersicum L.) is the second most important vegetable crop in the world due to its high level of nutrition particularly in vitamins and antioxidants. It is grown in several ecologies of the world due to its adaptability and ease of cultivation. Besides field conditions, tomatoes are grown in controlled environments which range from hydroponics and simple high tunnel structures to highly automated screen houses in advanced countries. However, the yield and quality of the fruits are highly influenced by the environment. This results in unpredictable performances in different growing environments in terms of quality, a phenomenon known as genotype by environment (G × E) interaction which confounds selection efficiency. Various approaches are employed by plant breeders to evaluate and address the challenges posed by genotype by environment interaction. This chapter discusses various field and controlled environments for growing tomatoes and the effect of these environments on the performance of the crop. The various types of genotype × environment interactions and their effect of the tomato plant are discussed. Finally, efforts are made to suggest ways and methods of mitigating the confounding effects of genotype × environment interaction including statistical approaches.",book:{id:"6422",slug:"recent-advances-in-tomato-breeding-and-production",title:"Recent Advances in Tomato Breeding and Production",fullTitle:"Recent Advances in Tomato Breeding and Production"},signatures:"Michael Kwabena Osei, Benjamin Annor, Joseph Adjebeng-\nDanquah, Agyemang Danquah, Eric Danquah, Essie Blay and Hans\nAdu-Dapaah",authors:[{id:"204223",title:"Dr.",name:"Agyemang",middleName:null,surname:"Danquah",slug:"agyemang-danquah",fullName:"Agyemang Danquah"},{id:"217531",title:"M.Sc.",name:"Michael Kwabena",middleName:null,surname:"Osei",slug:"michael-kwabena-osei",fullName:"Michael Kwabena Osei"},{id:"217760",title:"Dr.",name:"Joseph",middleName:null,surname:"Adjebeng-Danquah",slug:"joseph-adjebeng-danquah",fullName:"Joseph Adjebeng-Danquah"},{id:"217768",title:"MSc.",name:"Benjamin",middleName:null,surname:"Annor",slug:"benjamin-annor",fullName:"Benjamin Annor"},{id:"247378",title:"Dr.",name:"Eric Y.",middleName:null,surname:"Danquah",slug:"eric-y.-danquah",fullName:"Eric Y. Danquah"},{id:"248095",title:"Prof.",name:"Essie",middleName:null,surname:"Blay",slug:"essie-blay",fullName:"Essie Blay"},{id:"248096",title:"Prof.",name:"Hans",middleName:null,surname:"Adu-Dapaah",slug:"hans-adu-dapaah",fullName:"Hans Adu-Dapaah"}]},{id:"45153",title:"Irrigation of Sandy Soils, Basics and Scheduling",slug:"irrigation-of-sandy-soils-basics-and-scheduling",totalDownloads:5600,totalCrossrefCites:4,totalDimensionsCites:10,abstract:null,book:{id:"3357",slug:"crop-production",title:"Crop Production",fullTitle:"Crop Production"},signatures:"Mohamed S. Alhammadi and Ali M. Al-Shrouf",authors:[{id:"78245",title:"Dr.",name:"Mohamed",middleName:"Salman",surname:"Alhammadi",slug:"mohamed-alhammadi",fullName:"Mohamed Alhammadi"},{id:"159904",title:"Mr.",name:"Ali",middleName:null,surname:"Al-Shrouf",slug:"ali-al-shrouf",fullName:"Ali Al-Shrouf"}]}],onlineFirstChaptersFilter:{topicId:"29",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81888",title:"Reducing Soil Compaction from Equipment to Enhance Agricultural Sustainability",slug:"reducing-soil-compaction-from-equipment-to-enhance-agricultural-sustainability",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104489",abstract:"The compaction of agricultural soils cannot be solved, only managed. As a compressible media, soil travel without causing some collapse of the existing structure is impossible. If left uncorrected, farmers can see up to a 50% reduction in yield from long-term compaction. This chapter will describe the effects of soil compaction on the environment, crop quality, and economic sustainability. The base causes will be examined, along with the engineering designs for vehicles that minimize the problem. The tracks versus tires debate will be thoroughly discussed, and the advantages and disadvantages of each system will be detailed. It will be shown that although tires represent the likely current best economic option for vehicle support, the potential of tracks to reduce compaction has been fully exploited. The advantages of four-wheel drive vehicles in reducing soil compaction will be shown, along with the mitigation potential of independently driven wheels and active soil interaction feedback loops. The design of crop production tillage equipment and tillage tool working points will be explored, along with the concept of critical tillage depth. Equipment for compaction relief will also be discussed, as will the sustainable agricultural protocols of cover crops, crop rotation, and controlled traffic farming.",book:{id:"11357",title:"Sustainable Crop Production - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg"},signatures:"Michael M. Boland, Young U. Choi, Daniel G. Foley, Matthew S. Gobel, Nathan C. Sprague, Santiago Guevara-Ocana, Yury A. Kuleshov and Robert M. Stwalley III"},{id:"81378",title:"Sustainability-Based Review of Irrigation Schemes Performance for Sustainable Crop Production in Nigeria",slug:"sustainability-based-review-of-irrigation-schemes-performance-for-sustainable-crop-production-in-nig",totalDownloads:31,totalDimensionsCites:0,doi:"10.5772/intechopen.103980",abstract:"Irrigated agriculture has been identified as an important practice to achieving food security and socio-economic development in the face of rapid population growth and climatic uncertainties. In northern Nigeria, irrigation has long been identified as the key to achieving the much-desired increase in food production to meet the ever-increasing population. However, the existing irrigation schemes encountered several challenges coming from different dimensions including economic, social, environmental, institutional and technological. To attain sustainable crop production, this paper attempts to uncover the underline challenges confronting irrigation schemes in northern Nigeria that cut across sustainability pillars. The findings revealed that irrigation schemes contributed immensely toward achieving food security and improving the wellbeing of rural dwellers. However, the huge investment in large- and medium-scale irrigation schemes have resulted in massive economic losses. This could be attributed to their under-utilization, poor management and abandonment although few ones are performing remarkably well. The study recommends the need to adopt new water allocation and application methods that can improve water use efficiency, users-managers join approach (participatory), effective and competent institutions which include improved monitoring, evaluation and surveillance systems, frequent policy review to suit the situation, law enforcement, and timely sensitization and awareness campaigns.",book:{id:"11357",title:"Sustainable Crop Production - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg"},signatures:"Nura Jafar Shanono, Nura Yahaya Usman, Mu’azu Dantala Zakari, Habibu Ismail, Shehu Idris Umar, Sunusi Abubakar Amin and Nuraddeen Mukhtar Nasidi"},{id:"81274",title:"Toward the Recent Advances in Nutrient Use Efficiency (NUE): Strategies to Improve Phosphorus Availability to Plants",slug:"toward-the-recent-advances-in-nutrient-use-efficiency-nue-strategies-to-improve-phosphorus-availabil",totalDownloads:43,totalDimensionsCites:0,doi:"10.5772/intechopen.102595",abstract:"Achieving high nutrient use efficiency (NUE) and high crop productivity has become a challenge with increased global demand for food, depletion of natural resources, and deterioration of environmental conditions. Higher NUE by plants could reduce fertilizer input costs, decrease the rate of nutrient losses, and enhance crop yields. Nitrogen and Phosphorus are the most limiting nutrients for crop production in many of the world’s agricultural areas, and their efficient use is important for the economic sustainability of cropping systems. Furthermore, the dynamic nature of N and P in soil-plant systems creates a unique and challenging environment for its efficient management. Although numerous fertilizer recommendation methods have been proposed to improve NUE, technologies and innovative management practices are still lacking. Therefore, maximizing crop phosphorus (P) use efficiency (PUE) would be helpful in reducing the use of inorganic phosphorus fertilizers and their escape in the environment for sustainable agriculture. Improvement of PUE in cropping systems can be achieved through two main strategies: optimizing agronomic practice and breeding nutrient efficient crop cultivars that improves P-acquisition and -utilization efficiency. These strategies are needed for future food security and sustainable agriculture. The major revised points are the following: concept of NUE, application of nutrient stewardship, cereal-legume intercropping, regulating soil pH, etc., for enhancing phyto-availability of P and breeding P-efficient crop cultivars that can produce more biomass with lesser P costs and that acquire more P in P-stress condition. These approaches consider economic, social, and environmental dimensions essential to sustainable agricultural systems and afford a suitable context for specific NUE indicators.",book:{id:"11357",title:"Sustainable Crop Production - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg"},signatures:"Addisu Ebbisa"},{id:"81179",title:"Crop Diversification an Effective Strategy for Sustainable Agriculture Development",slug:"crop-diversification-an-effective-strategy-for-sustainable-agriculture-development",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.102635",abstract:"Sustainable agricultural practices involve a variety of approaches. The most important approached for sustainable agriculture development is crop diversification. It allowing the farmers to employ biological cycles to minimize inputs, conserve the resource base, maximize yields and also reduce the risk due to ecological and environmental factors. It serves as an important opportunity to augment income and employment generation for rural communities. Crop diversification promotes the interaction of beneficial soil bacteria, interrupts the disease cycle, and reduces the quantity of weeds. Crop diversification boosts land-use efficiency and crop output by improving the physical and chemical qualities of soil. Crop diversification shows a lot of scope to alleviating the problems such as resurgence of insects-pests and weeds, soil degradation, environmental pollution, soil salinity, decline farm profit and climate change. Crop diversification through crop intensification system enhanced the net returns, B:C ratio, and overall system productivity of a farm. In order to achieve the benefits of crop diversification farmers are shifting from low value low yielding crops to high value high yielding crops. Thus, crop diversification has the sound capacity for achieving the goal of nutritional security, income growth, food security, employment generation and sustainable agriculture development.",book:{id:"11357",title:"Sustainable Crop Production - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg"},signatures:"Anamika Barman, Priyanka Saha, Shashank Patel and Anurag Bera"},{id:"80867",title:"Potential Applications of Rhizobacteria as Eco-Friendly Biological Control, Plant Growth Promotion and Soil Metal Bioremediation",slug:"potential-applications-of-rhizobacteria-as-eco-friendly-biological-control-plant-growth-promotion-an",totalDownloads:66,totalDimensionsCites:0,doi:"10.5772/intechopen.102657",abstract:"Modern agriculture has an immense problem in the depletion of agricultural productivity owing to a variety of biotic and abiotic stresses. Agriculture’s sustainability and safety are dependent on ecologically friendly practices. Plant rhizobia have been proven to have an important role in disease control, as well as promoting plant growth, productivity, and biomass. Rhizobacteria are soil bacteria that live on the root surface and either directly or indirectly contribute to plant development. Rhizobia are used to induce mediated immune resistance through the manufacture of lytic enzymes, antibiotics, phytoalexins, phytohormone, metabolites. It supports the growth of plants through nitrogen fixation, nutrient enrichment, phosphate solubilization and phytohormone synthesis. In addition, it supports plants during different stresses such as temperature, osmotic, heavy metal and oxidative stress. Plant growth-promoting rhizobacteria have the ability to control heavy metal pollution of soils as well as enhancing plant growth in these soils. Efficient bioremediation is possible by using rhizobacterial inoculants, still, the distribution and functioning of microbes in the rhizosphere need to be fully explored. This review focuses on the effectiveness, biomonitoring processes and function in promoting plant development. Rhizobia application can be considered an alternative method for the improvement of biodiversity, agriculture, and the environment.",book:{id:"11357",title:"Sustainable Crop Production - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg"},signatures:"Nafeesa Farooq Khan, Aatifa Rasool, Sheikh Mansoor, Sana Saleem, Tawseef Rehman Baba, Sheikh Maurifatul Haq, Sheikh Aafreen Rehman, Charles Oluwaseun Adetunji and Simona Mariana Popescu"},{id:"80653",title:"Heavy Metal Contamination in Vegetables and Their Toxic Effects on Human Health",slug:"heavy-metal-contamination-in-vegetables-and-their-toxic-effects-on-human-health",totalDownloads:127,totalDimensionsCites:1,doi:"10.5772/intechopen.102651",abstract:"Vegetables are a prevalent nutrition for people all over the world because they are high in important nutrients, antioxidants, and metabolites that function as buffers for acidic compounds created during digestion. Vegetables, on the other hand, absorbed both vital and poisonous substances through the soil. Possible human health concerns, including as cancer and renal damage, have been linked to the consumption of heavy metal-contaminated vegetables (HMs). Heavy metals like Cr, Mn, Fe, Ni, Cu, Zn, Cd, Pb, and Hg were found in high concentrations in popular vegetables such as Amaranthus tricolour L., Chenopodium album L., Spinacia oleracea, Coriandrum sativum, Solanum lycopersicum, and Solanum melongena. The toxicity, fortification, health hazard, and heavy metals sources grown in soil are detailed in this review study.",book:{id:"11357",title:"Sustainable Crop Production - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11357.jpg"},signatures:"Seema Manwani, Vanisree C.R., Vibha Jaiman, Kumud Kant Awasthi, Chandra Shekhar Yadav, Mahipal Singh Sankhla, Pritam P. 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In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain. She is a Full Professor at the Department of Medicine and Animal Surgery at the same University. She developed her research activity in the field of Endocrinology, Hematology, Biochemistry and Immunology of horses. She is a scientific reviewer of several international journals : American Journal of Obstetrics and Gynecology, Comparative Clinical Pathology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology. Since 2014, she has been the Head of the Clinical Analysis Laboratory of the Hospital Clínico Veterinario from the Faculty of Veterinary, CEU-Cardenal Herrera University.",institutionString:"CEU-Cardenal Herrera University",institution:{name:"CEU Cardinal Herrera University",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"208123",title:"Dr.",name:"Mari-Carmen",middleName:null,surname:"Uribe",slug:"mari-carmen-uribe",fullName:"Mari-Carmen Uribe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"345713",title:"Dr.",name:"Csaba",middleName:null,surname:"Szabó",slug:"csaba-szabo",fullName:"Csaba Szabó",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"345719",title:"Mrs.",name:"Márta",middleName:null,surname:"Horváth",slug:"marta-horvath",fullName:"Márta Horváth",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"420151",title:"Prof.",name:"Novirman",middleName:null,surname:"Jamarun",slug:"novirman-jamarun",fullName:"Novirman Jamarun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Andalas University",country:{name:"Indonesia"}}}]}},subseries:{item:{id:"90",type:"subseries",title:"Human Development",keywords:"Neuroscientific research, Brain functions, Human development, UN’s human development index, Self-awareness, Self-development",scope:"