Open access peer-reviewed chapter

A Review of the Antidiabetic Activities of Ginger

Written By

Gloria Aderonke Otunola and Anthony Jide Afolayan

Submitted: 26 April 2019 Reviewed: 29 July 2019 Published: 27 November 2019

DOI: 10.5772/intechopen.88899

From the Edited Volume

Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials

Edited by Haiping Wang

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Diabetes mellitus, a chronic metabolic disorder with major health care burden worldwide, is increasing, with 173 million adults being diabetic and over 8 million deaths recorded annually. Undesirable pathological conditions and high rates of secondary failure limit the use of current antidiabetic agents, thus, the need for more effective antidiabetic agents. Medicinal plants such as spices, rich in bioactive components that promote prevention and treatment of chronic conditions such as heart disease, cancer and Type-2 diabetes, are inexpensive with no side effects. The Zingiberaceae family, of which ginger is a member, consists of many species frequently cited for their antidiabetic and hypoglycemic properties. All important scientific literatures from 2000 to 2018 on the antidiabetic potentials of Zingiber officinale were evaluated. According to these studies, ginger exerts its antidiabetic effects through restorative effects on pancreatic β-cells, increasing insulin sensitivity, action and peripheral utilization of glucose. Other mechanisms include increased synthesis of hepatic glycogen through the enhancement of glycogen regulatory enzyme expression in the liver, inhibition of carbohydrate metabolizing enzymes, stimulation of pancreatic insulin release and inhibition of hepatic glucose production. Further studies, especially in humans are needed, more so, since ginger is one of the spices generally regarded as safe.


  • spices
  • diabetes
  • ginger
  • pharmacology
  • mechanism of action

1. Introduction

Diabetes mellitus (DM) is the most common endocrine disorder that affects more than 100 million people worldwide. It is a heterogeneous group of diseases, all of which ultimately lead to an elevation of glucose in the blood (hyperglycemia) and loss of glucose in the urine as hyperglycemia increases. It is characterized by increased urine production (polyurea) excessive thirst (polydipsia) and excessive eating (polyphagia).

Diabetes mellitus is a chronic metabolic disorder of the endocrine system that is characterized by defects in impaired metabolism of glucose, lipid and protein as well as insulin secretion or insufficiency. Diabetes continues to be a major health care problem worldwide and its prevalence is expected to rise from the current 382–471 million individuals by 2035 [1, 2]. There are three main types of diabetes-Type 1 diabetes (T1D), which is an autoimmune disorder leading to the destruction of pancreatic beta-cells; Type 2 diabetes (T2D), which is much more common and primarily caused by impaired glucose regulation due to a combination of dysfunctional pancreatic beta cells and insulin resistance and gestational diabetes mellitus (GDM).

Different treatments, such as insulin, pharmacotherapy and diet therapies, which exert antidiabetic effects through different mechanisms, are currently used for the management of diabetes. Such mechanisms include stimulation of insulin secretion by sulfonylurea and meglitinides drugs, increase of peripheral absorption of glucose by biguanides and thiazolidinediones, delay in the absorption of carbohydrates from the intestine by alpha-glucosidase and reduction of hepatic gluconeogenesis by biguanides [3, 4, 5].

In spite of the appreciable progress that has been made in the management of diabetes through the use of conventional drugs and management strategies, diabetes and its complications continue to be a major medical problem and rising burden of disease. Most synthetic oral hypoglycemic agents available for the treatment of the disease have some disadvantages, including drug resistance, serious side effects, cannot be used during pregnancy, are toxic and also costly [6, 7].

Spices and herbs have played important roles in civilization and history of many nations of the world. Their flavor and pungency makes them indispensable in the preparation of palatable dishes; but beyond adding flavor, spices are reputed to possess several medicinal and pharmacological properties and hence find use in the preparation of a number of medicines. Spices can be the dried leaf (e.g., bay leaf), buds (cloves), bark (cinnamon), rhizome/root (ginger), berries (grains of pepper), seeds (cumin), or even the stigma of the flower (saffron) [8].

The Zingiberaceae plant family consists of many species used as culinary herbs and spices, frequently cited for their antidiabetic and hypoglycemic properties. Ginger (Zingiber officinale) belongs to this family, and has a long and wide history of usage both as a culinary spice and in traditional/alternative medicine. This study attempts to update the available scientific information on the antidiabetic and hypoglycemic potentials of ginger.


2. Methodology

Online published articles from Google Scholar, ScienceDirect, Scopus, ResearchGate, PubMed and SciELO were explored for data collection. For literature search, key words such as spices, diabetes, Zingiberaceae, ginger, in vivo, in vitro, pharmacological, medicinal, hypoglycemic and antidiabetic were used. The study reviewed all important literature from 2000 to 2018.


3. Results

The following sections describe various studies reporting the hypoglycemic and antidiabetic properties of ginger, phytochemical constituents responsible for these properties and its mechanisms of action.

3.1 Ginger (Zingiber officinale Roscoe)

The ginger (Zingiberaceae) family consists of 53 genera and over 1200 medicinal plants, typically tropical annuals or perennials, often with large rhizomes. This plant family is well-known for its medicinal values and is distributed widely throughout the tropics, particularly in Southeast Asia.

Ginger (Figure 1) has been used for thousands of years for the treatment of numerous ailments, such as colds, nausea, arthritis, migraines and hypertension. Several authors have reviewed the medicinal, chemical, and pharmacological properties of ginger [9, 10, 11, 12, 13]. Ginger is recognized by the U.S. Food and Drug Administration (FDA) as a food additive that is “generally recognized as safe” [14] and has a long history of use as a culinary spice and in herbal medicine to treat many ailments.

Figure 1.

Zingiber officinale (ginger) rhizomes. Source: [28].

Ginger helps to relieve various inflammatory disorders like gout, osteoarthritis and rheumatoid arthritis; as an analgesic, hypoglycemic, cardiotonic, antiemetic, antimicrobial and antifungal. Other uses include as an antidiabetic, antidyslipidemia, hypotensive, vasodilator, antiobesity and anticancer agent [15, 16, 17, 18].

In addition, the spice has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications [19]. Several experimental studies have reported that administration of ginger extracts significantly decreased blood glucose level in Type 1- and Type 2-induced diabetic animals in a dose-dependent pattern [20, 21, 22, 23, 24, 25, 26, 27].

3.2 Antidiabetic properties of ginger

Lamuchi-Deli et al. [29] evaluated the effects of the hydroalcoholic extract of Zingiber officinale on arginase I activity and expression in the retina of streptozotocin-induced diabetic rats. The study showed that blood glucose concentration was significantly decreased, arginase I activity and expression was significantly (P < 0.05) down regulated and 400 mg/kg of the extract reduced significant elevation in body weight in diabetic rats compared to untreated diabetic controls (P < 0.01). Serum insulin was also significantly increased in diabetic rats treated with 400 mg/kg of the extract compared to diabetic controls (P < 0.05). The study suggested that ginger could be a promising therapeutic option for treating diabetes-induced vascular disorders.

A recent study by de Las Heras et al. [30] which evaluated the hypolipidemic-and insulin sensitizing effects of hydroethanolic extract of ginger in the liver of high-fat diet (HFD) fed rats, revealed that ginger extract improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats. Wei et al. [31], also reported that 6-Paradol and 6-Shogaol, the pungent compounds of ginger, promoted glucose utilization in adipocytes and myotubes, and 6-paradol reduced blood glucose in HFD-fed mice. Al-Qudah et al. [32] reported that aqueous extract of ginger was effective in lowering serum glucose, restoration of hematological indices to normal and repair damaged pancreas in alloxan-induced diabetic rats.

In another study, Oludoyin and Adegoke [33] investigated the effect of ginger extracts on blood glucose in normal and streptozotocin-induced diabetic rats. The authors reported that the fasting blood glucose in diabetic rats was reduced to normal by both raw and cooked ginger extracts in a manner comparable to glibenclamide. Evaluation of the nutritional and antidiabetic activity of ginger powder, its aqueous and methanolic extract, as well as the essential oil in streptozotocin-induced diabetic rats [34] revealed reduction in levels of alanine and aspartate aminotransferase (ALT and AST), alkaline phosphatase (ALP), liver total lipid and cholesterol of diabetic rats; and increased levels of liver glycogen and triglyceride compared to positive control group. In the study, ginger oil showed the best antidiabetic activity, followed by ginger extracts. Again, another study reported that ginger extract administered at 200 mg/kg/day/kg body weight for 10 weeks to male Sprague-Dawley diabetic rats, exhibited protective activity against insulin resistance [34].

Al-Noory et al. [35] showed that fresh ginger extracts led to decrease in the levels of total cholesterol (TC) and low density lipoprotein (LDL) in the serum of alloxan-induced diabetic rats, compared with the control groups; and previous extracts caused reduction in LDL to levels comparable to normal group and equal to the effect of atorvastatin given at a dosage of 10 mg/day. Similarly, oral administration of aqueous ginger extract to streptozotocin (STZ)-induced diabetic rats for a period of 30 days was reported to give a dose-dependent antihyperglycemic effect, 68% decrease in plasma glucose level at a daily dose of 500 mg/kg body weight, indicating that ginger is a potential phytomedicine for the treatment of diabetes [36]. Iranloye et al. [37] also showed that ginger effectively reduced fasting blood glucose, malondialdehyde levels and enhanced insulin sensitivity in alloxan-induced and insulin-resistant diabetic rats compared to control rats.

Treatment of streptozotocin-induced Type I diabetic rats with Z. officinale juice (4 mL kg−1, p.o. daily for 6 weeks) was reported to produce a significant increase in insulin levels, decrease in fasting glucose levels, as well as significant decrease in the area under the curve of glucose in an oral glucose tolerance test [38]. According to Nammi et al. [23], treatment with an ethanolic extract of ginger at doses of 100, 200, and 400 mg/kg for 6 weeks, significantly reduced the marked increase in body weight, serum glucose, insulin, total cholesterol, LDL cholesterol, triglycerides, free fatty acid and phospholipids induced by high-fat diet.

The study conducted by Al-Amin et al. [39] on the antidiabetic and hypolipidemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats revealed that raw ginger at a dose of 500 mg/kg, was significantly effective in lowering serum glucose, cholesterol and triacylglycerol as well as reduction in urine protein (reversal of diabetic proteinuria) levels, of diabetic rats. Ethanolic extracts of Zingiber officinale (200 mg/kg) given orally for 20 days was reported to produce significant antihyperglycemic effect (P < 0.01) in diabetic rats, while also lowering serum total cholesterol and triglycerides, coupled with increased HDL-cholesterol levels when compared with pathogenic diabetic rats [40].

Hypoglycemic effect of ginger (4 and 8 g/kg), administered intraperitoneally to rats after 30 min of diabetes induction, with the effect being more pronounced after 2 h has been reported. In another study, Otunola and Afolayan [41], showed that aqueous extract of a spice mixture containing ginger at 500 mg/kg body weight extract significantly (p < 0.05) lowered the elevated fasting blood glucose, lipid and hematological indices of alloxan-induced diabetic rats at equipotent level with glibenclamide.

Several in vitro hypoglycemic potentials of ginger and its bioactive constituents especially 6-shogaol have been reported (Table 1).

In vitro study Result/outcome References
[6]-Gingerol on 3 T3-L1 cells Enhanced differentiation of 3T3-L1 preadipocytes and insulin-sensitive glucose uptake Sekiya et al. [42]
[6]-Shogaol or [6]-gingerol on 3 T3-L1 cells Significant inhibition of TNF-α-mediated adiponectin expression in 3T3-L1 adipocytes.
[6]-Shogaol acted as a peroxisome proliferator-activated receptor (PPAR)γ agonist, while [6]-gingerol acted by suppressing TNF-α-induced JNKs signaling
Isa et al. [43]
Ethyl acetate extract of ginger on L6 myotube cell surface Stimulated glucose uptake and GLUT4 expression in L6 myotube cell surface, reduced lipid content in 3T3 adipocyte, and inhibited protein glycation.
Inhibited α-amylase (IC50 = 980.2 μg/mL) and α-glucosidase (IC50 = 180.1 μg/mL)
Rani et al., [44]
Aqueous extract of ginger at 5, 10, 20, 40 g/L incubated with (PBS), glucose + BSA for 5 weeks Dose-dependent, antidiabetic activity through inhibition of glucose diffusion and reduced glycation Sattar et al., [45]

Table 1.

In vitro hypoglycemic potentials of ginger and its bioactive constituents.

The capacity of ginger for hypoglycemic, antidiabetic, insulogenic, better glucose tolerance, increased serum insulin levels, reduction in elevated lipid levels, and prevention of weight loss associated with diabetes in human diabetic patients have also been reported (Table 2).

Human trials/dosage Results References
Type 2 diabetic men (40–60 years) given 3 g/day of dry ginger powder in divided doses for 30 days. Number-8 T2D, 8 placebo Significant reduction of blood glucose, triglyceride, total cholesterol, LDL and VLDL cholesterol Andallu et al. [48]
Randomized double-blind placebo-controlled trial, patients with Type 2 diabetes, given 2 g/day of ginger extract supplementation. Number-28 T2D, 30 Placebo Significantly lowered levels of insulin, LDL-C, TG, HOMA index and increased the QUICKI index; no significant changes in FPG, TC, HDL-C and HbA1c; improved insulin sensitivity Mahluji et al. [49]
Randomized controlled trial of Type 2 diabetic men between 30 and 70 years given 1.6 g/day of ginger or wheat flour capsule. Number-33 T2D, 30 Placebo Decreased fasting blood glucose, glycosylated hemoglobin, fasting insulin, homeostasis model assessment-insulin resistance index, total cholesterol and triglyceride. No change in BMI, LDL-C, LDL-C and HDL-C Arablou et al. [50]
Randomized controlled trial of Type 2 diabetic patients (30–70 years) given either 3 g/day ginger or cellulose microcrystalline capsules for 8 weeks. Number-40 T2D, 41Placebo Significant reduction in fasting blood glucose and glycosylated hemoglobin; no change in BMI, fasting insulin and homeostasis model assessment-insulin resistance index Mozaffari-Khosravi et al. [51]
Randomized, double-blind, placebo-controlled, clinical trial where Type 2 diabetic patients received 2 g/day of ginger powder supplement or lactose as placebo for 12 weeks. Number-22 T2D, 19 placebo Significant reduction of fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein B/apolipoprotein A-I and malondialdehyde in ginger group compared to baseline and control group, while increasing apolipoprotein A-I in Type 2 diabetic patients Khandouzi et al. [52]
Randomized controlled trial of Type 2 diabetic patients (20–60 y) T2DM given 3 g ginger or lactose capsule/day for 3 months. Number-22 T2D, 23 Placebo Reduced fasting blood glucose, glycosylated hemoglobin, fasting insulin, homeostasis model assessment-insulin resistance index Shidfar et al. [53]
Double-blind placebo-controlled trials of Type 2 diabetic patients were randomly allocated to 2000 mg/day of ginger or placebo for 10 weeks. Number-25 T2D, 25 placebo Reduced serum levels of fasting blood glucose, hemoglobin A1C compared to placebo group, reduced ratio of LDL-C/HDL-C; but no significant change in serum concentrations of triglycerides, total cholesterol, LDL-C, and HDL-C Arzatii et al. [54]

Table 2.

Clinical (human) trials of the antidiabetic potentials of ginger.

3.3 Phytochemical components of Zingiber officinale

GC-MS profiling of diethyl extracts as reported by Koch et al. [46] showed the presence of monoterpenes such as (α-pinene, camphene, myrcene, and α-phellandrene), oxygenated monoterpenes (geranial, citronellal, neral, linalool, borneol, and α-terpineol), and sesquiterpenes (α-and β-farnesene, ar-curcumene, zingiberene, zingiberenol, copaene, or cadinene). The most abundant substances in the extracts were α-zingiberene (37.9%), β-sesquiphellandrene (11.4%), (E,E)-α-farnesene (9.6%), geranial (8.2%), ar-curcumene (6.3%), and γ-terpinene (5.1%).

Similarly, Sharma et al. [47] reported that the essential oil of fresh ginger rhizome was characterized by high percentage of sesquiterpenes (66.66%), monoterpenes (17.28%) and aliphatic compounds (13.58%). The predominant sesquiterpene was zingiberene (46.71%) followed by valencene (7.61%), β-funebrene (3.09%) and selina-4(14),7(11)-diene (1.03%).

3.4 Mechanism of action

Various mechanisms have been proposed for the antidiabetic and hypoglycemic activities of medicinal plants. These include peripheral utilization of glucose, increased synthesis of hepatic glycogen by enhancement of glycogen regulatory enzyme expression in the liver, inhibition of carbohydrate metabolizing enzymes, stimulation of pancreatic insulin release, insulomimetic actions and inhibition of hepatic glucose production [55, 56].

According to Dearlove et al. [57], spices such as cinnamon, cloves, oregano, and allspice possess bioactive compounds that have (1) antiglycation properties which inhibit the formation of AGEs; (2) antioxidant activities that neutralize the effects of ROS; and (3) anti-inflammatory potentials. Some studies associate the antidiabetic action of ginger to its bioactive principles such as gingerol and shogaol which have the capacity to enhance glucose uptake in rat’s skeletal muscle cells, and promote increased expression and translocation of GLUT-4 glucose transporter to the plasma membrane of the cells thus clearing excess glucose from the serum [34].

Another mechanism proposed was the inhibition of key enzymes of carbohydrate metabolism-α-glucosidase and α-amylase by phenolic compounds (gingerols and shogaols) present in ginger [23, 45]; while other authors showed that ginger increases muscle and liver glycogen stores by enhancing peripheral utilization of glucose, thus limiting gluconeogenesis in the liver and kidney in a manner similar to insulin [37].

Son et al. [58], posits that-gingerol exerts its antidiabetic effects through multiple mechanisms that include—(1) increased glucose uptake in the absence of insulin, (2) induction of 5′ adenosine monophosphate-activated protein kinase phosphorylation, (3) promotion of glucose transporter 4 (GLUT4) translocation to plasma membrane, (4) suppression of advanced glycation end product-induced rise of ROS levels in pancreatic β-cells, (5) reduction of fasting blood glucose levels and improved glucose intolerance, (6) regulation of hepatic gene expression of enzymes involved in glucose metabolism toward decreased gluconeogenesis and glycogenolysis, while increasing glycogenesis, thereby reducing blood glucose concentrations.


4. Conclusion

This study presented an update on the antidiabetic potentials of ginger from the Zingiberaceae family. Although several in vivo and in vitro reports were available, there were relatively few clinical (human) trials. The doses and outcomes also varied; as well as the mechanism of action through which antidiabetic effects were mediated. Although these reports are indicative of the anti-diabetic or hypoglycemic potentials of ginger, the doses and outcomes also varied; most importantly, the mechanisms of action through which anti-diabetic effects are mediated were highlighted. Ginger, according to these studies, exerts its anti-diabetic effects through restorative effects on pancreatic β-cells, increasing insulin sensitivity, insulin-like action and peripheral utilization of glucose. Other mechanisms include increased synthesis of hepatic glycogen through the enhancement of glycogen regulatory enzyme expression in the liver, inhibition of carbohydrate metabolizing enzymes, stimulation of pancreatic insulin release, and inhibition of hepatic glucose production. However, further studies, especially in humans are therefore needed and the oral safety of the various extracts under prolonged usage must be confirmed, more so, since ginger is one of the spices generally regarded as safe.



The authors acknowledge the support of Govan Mbeki Research and Development Centre, University of Fort Hare.


Conflict of interest

The authors declare no conflict of interest.


  1. 1. Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. Global estimates for the prevalence of diabetes for 2015 and 2040. IDF Diabetes Atlas;2017(128):40-50
  2. 2. Bi X, Lim J, Henry CJ. Spices in the management of diabetes mellitus. Food Chemistry. 2017;217:281-293
  3. 3. Hui, Hongxiang, Xiaoning Zhao, and Riccardo Perfetti. Structure and function studies of glucagon-like peptide-1 (GLP-1): The designing of a novel pharmacological agent for the treatment of diabetes. Diabetes/Metabolism Research and Reviews. 2005;21(4):313-331
  4. 4. Bathaie SZ, Mokarizade N, Shirali S. An overview of the mechanisms of plant ingredients in the treatment of diabetes mellitus. Journal of Medicinal Plants. 2012;4(44):1-24
  5. 5. Kooti W, Farokhipour M, Asadzadeh Z, Ashtary-Larky D, Asadi-Samani M. The role of medicinal plants in the treatment of diabetes: A systematic review. Electronic Physician. 2016;8(1):1832
  6. 6. Kumari KD, Suresh KP, Samarasinghe K, Handunnetti SM, Samaranayake TSP. Evaluation of a traditional Sri Lankan herbal beverage (water extract of dried flowers of Aegle marmelos, Bael fruit) in type II diabetic patients. Journal of Diabetes and Metabolism. 2013;4(6)
  7. 7. Haque N, Salma U, Nurunnabi TR, Uddin MMJ, Jahangir FK, Islam SMZ, et al. Management of type 2 diabetes mellitus by lifestyle, diet and medicinal plants. Pakistan Journal of Biological Sciences. 2011;14:13-24
  8. 8. Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Pérez-Álvarez JA. Spices as functional foods. Critical Reviews in Food Science and Nutrition. 2010;51(1):13-28
  9. 9. Afzal M, Al-Hadidi D, Menon M, Pesek J, Dhabi MSG. An ethnomedicinal, chemical and pharmacological review. Drug Metabolism and Drug Interactions. 2001;18:159-190
  10. 10. Bode AM, Dong Z. The amazing and mighty ginger. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton, FL: CRC Press/Taylor & Francis; 2011. Available from:
  11. 11. Grzanna R, Lindmark L, Frondoza CG. Ginger—An herbal medicinal product with broad anti-inflammatory actions. Journal of Medicinal Food. 2005;8(2):125-132
  12. 12. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology. 2008;46(2):409-420
  13. 13. Ghayur MN, Gilani AH. Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Digestive Diseases and Sciences. 2005;50:1889-1897. DOI: 10.1007/s10620-005-2957-2
  14. 14. Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease? International Journal of Cardiology. 2009;131:408-409
  15. 15. Wu KL, Rayner CK, Chuah SK. Effects of ginger on gastric emptying and motility in healthy humans. European Journal of Gastroenterology & Hepatology. 2008;20(5):436-440
  16. 16. Qian QH, Yue W, Wang YX, Yang ZH, Liu ZT, Chen WH. Gingerol inhibits cisplatininduced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks. Archives of Pharmacal Research. 2009;32(4):565-573
  17. 17. Ojewole JAO. Analgesic, anti inflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytotherapy Research. 2006;20(9):764-772
  18. 18. Elkhishin IA, Ibrahim AA. A study of the cardiovascular toxic effects of Zingiber officinale (ginger) in adult male albino rats and its possible mechanisms of action. Mansoura Journal of Forensic Medicine and Clinical Toxicology. 2009;17(2):109-127
  19. 19. Singh A, Sanjiv D, Jaswinder S, Shankar K. Experimental advances in pharmacology of gingerol and analogues. Pharmacy Global: International Journal of Comprehensive Pharmacy. 2010;2(4)
  20. 20. Salim KS. Hypoglycemic property of ginger and green tea and their possible mechanisms in diabetes mellitus. Open Conference Proceedings Journal. 2014;5:13-19
  21. 21. Yiming L, Van HT, Colin CD, Basil DR. Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: A brief review. Evidence-based Complementary and Alternative Medicine. 2012:10. Article ID 516870
  22. 22. Kalejaiye OF, Iwalewa EO, Omobuwajo OR, Oyedapo OO. Hypoglycaemic effects of Nigerian Zingiber officinale rhizome on experimental diabetic rats. Nigerian Journal of Natural Products and Medicine. 2002;6(1):33-35
  23. 23. Nammi S, Satyanarayana S, Basil DR. Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic & Clinical Pharmacology & Toxicology. 2009;104(5):366-373
  24. 24. Abdulrazaq NB, Maung MC, Ni NW, Rahela Z, Mohammad TR. Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. British Journal of Nutrition. 2012;108(7):1194-1201
  25. 25. Jafri SA, Sohail A, Muhammad Q. Hypoglycemic effect of ginger (Zingiber officinale) in alloxan induced diabetic rats (Rattus norvagicus). Pakistan Veterinary Journal. 2011;31(2):160-162
  26. 26. Morakinyo AO, Akindele AJ, Ahmed Z. Modulation of antioxidant enzymes and inflammatory cytokines: Possible mechanism of anti-diabetic effect of ginger extracts. African Journal of Biomedical Research. 2011;14(3):195-202
  27. 27. Lindstedt I. Ginger and diabetes: A mini-review. Archives of General Internal Medicine. 2018;2(2):29-33
  28. 28. [Accessed: 18 July 2018]
  29. 29. Lamuchi-Deli N, Mohammad A, Hossein B-R, Ghorban M. Effects of the hydroalcoholic extract of Zingiber officinale on arginase I activity and expression in the retina of streptozotocin-induced diabetic rats. International Journal of Endocrinology and Metabolism. 2017;15(2)
  30. 30. de La Heras N, Munoz VM, Fernandez MB, Ballesteros S, Farre LA, Roso RB, et al. Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet. Applied Physiology, Nutrition, and Metabolism. 2017;42:209-215
  31. 31. Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, et al. 6-Paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet-fed mice. International Journal of Molecular Sciences. 2017;18:168
  32. 32. Al-Qudah MMA, Moawiya AH, El-Qudah JMF. The effects of aqueous ginger extract on pancreas histology and on blood glucose in normal and alloxan monohydrate-induced diabetic rats. Biomedical Research. 2016;27(2)
  33. 33. Oludoyin AP, Adegoke SR. Effect of ginger (Zingiber officinale) extracts on blood glucose in normal and streptozotocin-induced diabetic rats. International Journal of Clinical Nutrition. 2014;2:32-35
  34. 34. Anfenan MLK. Evaluation of nutritional and antidiabetic activity of different forms of ginger in rats. Middle-East Journal of Scientific Research. 2014;21:56-62
  35. 35. Al-Noory AS, Amreen AN, Hymoor S. Antihyperlipidemic effects of ginger extracts in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in (rats). Pharmacognosy Resarch. 2013;5:157-161
  36. 36. Abdulrazaq N, Cho M, Win N, Zaman R, Rahman M. Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. British Journal of Nutrition. 2012;108(7):1194-1201. DOI: 10.1017/S0007114511006635
  37. 37. Iranloye BO, Arikawe AP, Rotimi G, Sogbade AO. Anti-diabetic and anti-oxidant effects of Zingiber officinale on alloxan-induced and insulin-resistant diabetic male rats. Nigerian Journal of Physiological Sciences. 2011;26(1)
  38. 38. Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. The Journal of Pharmacy and Pharmacology. 2004;56:101-105
  39. 39. Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. British Journal of Nutrition. 2006;96(4):660-666
  40. 40. Bhandari U, Kanojia R, Pillai K. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. Journal of Ethnopharmacology. 2005;97:227-230. DOI: 10.1016/j.jep.2004.11.011
  41. 41. Otunola GA, Afolayan AJ. Antidiabetic effect of combined spices of Allium sativum, Zingiber officinale and Capsicum frutescens in alloxan-induced diabetic rats. Frontiers in Life Science. 2015;8(4):314-323
  42. 42. Sekiya K, Ohtani A, Kusano S. Enhancement of insulin sensitivity in adipocytes by ginger. Bio Factors. 2004;22(1-4):153-156
  43. 43. Isa Y, Miyakawa Y, Yanagisawa M, et al. [6]-Shogaol and [6]-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications. 2008;373(3):429-434
  44. 44. Rani MP, Krishna MS, Padmakumari KP, Raghu KG, Sundaresan A. Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: An in vitro study. Journal of the Science of Food and Agriculture. 2012;92(9):1948-1955
  45. 45. Sattar NA, Hussain F, Iqbal T, Sheikh MA. Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe. Brazilian Journal of Pharmaceutical Sciences. 2012;48(4):601-607
  46. 46. Andallu B, Radhika B, Suryakantham V. Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia. Plant Foods for Human Nutrition. 2003;58(3):1-7
  47. 47. Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SEJ. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. International Journal of Food Sciences and Nutrition. 2013;64(6):682-686. DOI: 10.3109/09637486.2013.775223
  48. 48. Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition. 2014;65(4):515-520
  49. 49. Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Complementary Therapies in Medicine. 2014;22(1):9-16
  50. 50. Khandouzi N, Farzad S, Asadollah R, Tayebeh R, Payam H, Mohsen MT. The effects of ginger on fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein AI and malondialdehyde in type 2 diabetic patients. Iranian Journal of Pharmacy Research. 2015;14(1):131
  51. 51. Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of Complementary and Integrative Medicine. 2015;12(2):165-170
  52. 52. Arzati MM, Honarvar NM, Saedisomeolia A, Anvari S, Effatpanah M, Arzati RM, et al. The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes. International Journal of Endocrinology and Metabolism. 2017;15(4):e57927. DOI: 10.5812/ijem.57927
  53. 53. Koch W, Kukula-Koch W, Marzec Z, Kasperek E, Wyszogrodzka-Koma L, Szwerc W, et al. Application of chromatographic and spectroscopic methods towards the quality assessment of ginger (Zingiber officinale) rhizomes from ecological plantations. International Journal of Molecular Sciences. 2017;18(2):452
  54. 54. Sharma PK, Singh V, Ali M. Chemical composition and antimicrobial activity of fresh rhizome essential oil of Zingiber officinale Roscoe. Pharmacognosy Journal. 2016;8(3):185-190
  55. 55. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A. Medicinal plants with potential antidiabetic activity—A review of ten years of herbal medicine research (1990-2000). International Journal of Diabetes and Metabolism. 2006;14:1-25
  56. 56. Yatoo MI, Saxena A, Gopalakrishnan A, Alagawany M, Dhama K. Promising antidiabetic drugs, medicinal plants and herbs: An update. International Journal de Pharmacologie. 2017;13:732-745
  57. 57. Dearlove RP, Greenspan P, Hartle DK, Swanson RB, Hargrove JL. Inhibition of protein glycation by extracts of culinary herbs and spices. Journal of Medicinal Food. 2008;11(2):275-281
  58. 58. Son MJ, Miura Y, Yagasaki K. Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice. Cytotechnology. 2015;67:641

Written By

Gloria Aderonke Otunola and Anthony Jide Afolayan

Submitted: 26 April 2019 Reviewed: 29 July 2019 Published: 27 November 2019