Results of multi-period portfolio management with MV and BL models.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5471",leadTitle:null,fullTitle:"Frontiers in Staphylococcus aureus",title:"Frontiers in Staphylococcus aureus",subtitle:null,reviewType:"peer-reviewed",abstract:"Staphylococcus was first recognized as a human pathogen in 1880 and was named for its grape cluster-like appearance. In 1884, Staphylococcus aureus was identified and named for its vibrant golden color, which was later found to be the result of golden toxin production. Here, experts examine in-depth patterns of S. aureus colonization and exposures in humans, mammals, and birds that have led to the development of various clinical diseases. The mode of transmission of S. aureus and different methods for its detection in different samples are defined. Conventional antibiotic options to treat this aggressive, multifaceted, and readily adaptable pathogen are becoming limited. Alternative, novel chemotherapeutics to target S. aureus are discussed in the pages within, including herbal medicines, bee products, and modes of delivery.",isbn:"978-953-51-2982-0",printIsbn:"978-953-51-2981-3",pdfIsbn:"978-953-51-5473-0",doi:"10.5772/63039",price:119,priceEur:129,priceUsd:155,slug:"frontiers-in-i-staphylococcus-aureus-i-",numberOfPages:234,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"514afc8c2d4eb28ddca22c032ad96d9e",bookSignature:"Shymaa Enany and Laura E. Crotty Alexander",publishedDate:"March 8th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5471.jpg",numberOfDownloads:23882,numberOfWosCitations:38,numberOfCrossrefCitations:34,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:62,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:134,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 20th 2016",dateEndSecondStepPublish:"May 11th 2016",dateEndThirdStepPublish:"August 15th 2016",dateEndFourthStepPublish:"November 13th 2016",dateEndFifthStepPublish:"December 13th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",biography:"Dr. Shymaa Enany is an Associate Professor of Microbiology, at Suez Canal University, Egypt, and is currently working at Armed Forces College of Medicine, Egypt. She received her Ph.D. from the School of Medical Sciences, Niigata University, Japan. She completed her post-doctoral studies in the United States and Japan. Dr. Enany was one of the first Arab scientists to apply bacterial proteomic techniques to reveal good markers for microbes spreading in the community. She has received many awards for her scientific contributions, including the 2021 International Science Council Award for Early Career Scientist in Africa, the 2019 Egyptian state encouragement prize for women in the field of health and pharmaceutical sciences, and the 2018 World Academy of Sciences Young Arab Scientist Prize in Medical Sciences.",institutionString:"Suez Canal University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"194113",title:"Dr.",name:"Laura",middleName:"Elise",surname:"Crotty Alexander",slug:"laura-crotty-alexander",fullName:"Laura Crotty Alexander",profilePictureURL:"https://mts.intechopen.com/storage/users/194113/images/5205_n.jpg",biography:"Dr. Laura E. Crotty Alexander is a Pulmonary Critical Care physician at the University of California, San Diego, and VA San Diego Healthcare System. As a biomedical basic science researcher, she studies host-pathogen interactions at molecular, cellular, organ, and organism levels and recently defined pro-virulent effects of inhalants such as cigarette smoke and e-cigarette vapor on Staphylococcal virulence. Dr. Crotty Alexander’s clinical interests include bacterial pneumonia and sepsis, e-cigarette effects on innate immunity, and moderate-to-severe asthma.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"906",title:"Bacteriology",slug:"pure-microbiology-bacteriology"}],chapters:[{id:"54154",title:"Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach",doi:"10.5772/67338",slug:"staphylococcus-aureus-overview-of-bacteriology-clinical-diseases-epidemiology-antibiotic-resistance-",totalDownloads:7174,totalCrossrefCites:14,totalDimensionsCites:25,hasAltmetrics:1,abstract:"Staphylococcus aureus is an important human pathogen that causes wide range of infectious conditions both in nosocomial and community settings. The Gram-positive pathogen is armed with battery of virulence factors that facilitate to establish infections in the hosts. The organism is well known for its ability to acquire resistance to various antibiotic classes. The emergence and spread of methicillin-resistant S. aureus (MRSA) strains which are often multi-drug resistant in hospitals and subsequently in community resulted in significant mortality and morbidity. The epidemiology of MRSA has been evolving since its initial outbreak which necessitates a comprehensive medical approach to tackle this pathogen. Vancomycin has been the drug of choice for years but its utility was challenged by the emergence of resistance. In the last 10 years or so, newer anti-MRSA antibiotics were approved for clinical use. However, being notorious for developing antibiotic resistance, there is a continuous need for exploring novel anti-MRSA agents from various sources including plants and evaluation of non-antibiotic approaches.",signatures:"Arumugam Gnanamani, Periasamy Hariharan and Maneesh Paul-\nSatyaseela",downloadPdfUrl:"/chapter/pdf-download/54154",previewPdfUrl:"/chapter/pdf-preview/54154",authors:[{id:"192829",title:"Dr.",name:"Arumugam",surname:"Gnanamani",slug:"arumugam-gnanamani",fullName:"Arumugam Gnanamani"},{id:"204388",title:"Dr.",name:"Periasamy",surname:"Hariharan",slug:"periasamy-hariharan",fullName:"Periasamy Hariharan"},{id:"204389",title:"Dr.",name:"Maneesh",surname:"Paul-Satyaseela",slug:"maneesh-paul-satyaseela",fullName:"Maneesh Paul-Satyaseela"}],corrections:null},{id:"53534",title:"Role of Nasal Staphylococcus aureus Carriage in Transmission Among Contact Athletes",doi:"10.5772/66936",slug:"role-of-nasal-staphylococcus-aureus-carriage-in-transmission-among-contact-athletes",totalDownloads:1537,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter focuses on Staphylococcus aureus (SA) infections in athletes. Previous SA infection studies performed starting in the 1980s examined close physical contact athletes, with a focus primarily on injured skin. However, more recent studies of skin SA transmission in athletes were conducted using molecular epidemiology. When participants in sports having a greater duration of competition were examined, results indicated that there was prolonged contact between athletes on the same team and athletes from other teams. These findings demonstrate that effective measures for preventing SA infections are urgently needed. Factors that can affect skin SA infections include high rates of SA nasal colonization, the type of “position on a team,” repeated skin-to-skin contact, and perspiration that occurs during exercise in SA nasal carriers. Thus, it should be possible to utilize molecular typing methods to assess skin-to-skin contact in athletes. This study summarizes the current understanding of SA infections in athletes. In order to develop preventive strategies, it will be necessary to further elucidate the predisposing factors and mechanisms behind SA infections and the subsequent transmission in athletes.",signatures:"Kotaro Suzuki",downloadPdfUrl:"/chapter/pdf-download/53534",previewPdfUrl:"/chapter/pdf-preview/53534",authors:[{id:"189571",title:"Dr.",name:"Kotaro",surname:"Suzuki",slug:"kotaro-suzuki",fullName:"Kotaro Suzuki"}],corrections:null},{id:"53782",title:"Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products",doi:"10.5772/66645",slug:"methicillin-resistant-staphylococcus-aureus-mrsa-in-food-producing-and-companion-animals-and-food-pr",totalDownloads:2743,totalCrossrefCites:8,totalDimensionsCites:16,hasAltmetrics:0,abstract:"Methicillin-resistant Staphylococcus aureus (MRSA) has become a growing concern in companion and food-producing animals. The presence of multidrug-resistance with a wide range of extracellular enterotoxin genes, virulence factors, and Panton-Valentine leukocidin (pvl) cytotoxin genes confer life-threatening traits on MRSA and makes them highly pathogenic and difficult to treat. Clonal complex 398 (CC398), a predominant clonal lineage of livestock-associated-MRSA in domestic animals and retail meat, is capable of infecting humans. In order to monitor and prevent MRSA contamination, it is critical to understand its source and transmission dynamics. In this review, we describe MRSA in food-producing animals (pig, cattle, chicken), horses, pet animals (dogs, cats), and food products (pork, beef, chicken, milk, and fish).",signatures:"Jungwhan Chon, Kidon Sung and Saeed Khan",downloadPdfUrl:"/chapter/pdf-download/53782",previewPdfUrl:"/chapter/pdf-preview/53782",authors:[{id:"189634",title:"Dr.",name:"Kidon",surname:"Sung",slug:"kidon-sung",fullName:"Kidon Sung"},{id:"190400",title:"Dr.",name:"Jungwhan",surname:"Chon",slug:"jungwhan-chon",fullName:"Jungwhan Chon"},{id:"190401",title:"Dr.",name:"Saeed",surname:"Khan",slug:"saeed-khan",fullName:"Saeed Khan"}],corrections:null},{id:"53035",title:"Effects of Electronic (e)-Cigarette Vapor on Staphylococcal Virulence: Are E-Cigarettes Safer than Conventional Cigarettes?",doi:"10.5772/66154",slug:"effects-of-electronic-e-cigarette-vapor-on-staphylococcal-virulence-are-e-cigarettes-safer-than-conv",totalDownloads:1553,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"In recent years, electronic (e)‐cigarettes have dramatically increased in popularity as an alternative to conventional cigarettes. Little is known about the effects of e‐cigarette vapor (EV) on bacteria that colonize the nasopharynx, including methicillin‐resistant Staphylococcusaureus (MRSA). As most cases of pneumonia can be traced to bacteria in a patient's nasopharynx, increased virulence in potential pathogens could have direct consequences clinically for these patients. And because bacterial colonizers are spread between humans, increased virulence in one subject has implications for the community. There is accumulating evidence that exposure to cigarette smoke (CS) increases the pathogenicity of MRSA, as well as its dampening effects on the host immune system. EV exposure has also been demonstrated to increase MRSA virulence both invitro and in a murine model of pneumonia. In this chapter, we will compare the virulence changes reported in MRSA exposed to CS vs. those exposed to EV, as well as proposed mechanisms and therapeutic targets.",signatures:"Laura E. Crotty Alexander, Shymaa Enany and Elisa McEachern",downloadPdfUrl:"/chapter/pdf-download/53035",previewPdfUrl:"/chapter/pdf-preview/53035",authors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"},{id:"194113",title:"Dr.",name:"Laura",surname:"Crotty Alexander",slug:"laura-crotty-alexander",fullName:"Laura Crotty Alexander"},{id:"195095",title:"Ms.",name:"Elisa",surname:"McEachern",slug:"elisa-mceachern",fullName:"Elisa McEachern"}],corrections:null},{id:"53377",title:"Staphylococcus aureus Bacteremia in Adults",doi:"10.5772/66225",slug:"staphylococcus-aureus-bacteremia-in-adults",totalDownloads:2103,totalCrossrefCites:3,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Staphylococcus aureus is an important cause of bacteremia, and S. aureus bacteremia constitutes a serious condition with high morbidity and mortality, secondary to multiple complications including infective endocarditis and embolization. The incidence of bacteremia with S. aureus is increasing with more frequent use of medications that lower immune system response, and with the utilization of more invasive medical procedures. In addition, the emergence of resistant S. aureus isolates is becoming more common and can negatively affect the outcome of an individual if not diagnosed and managed properly. Health care workers encounter S. aureus bloodstream infections on a routine basis, and in certain situations, it becomes a very challenging infection to control. Because of the impact this entity has on health care costs and the increased use of resources, it is necessary to highlight the causes, clinical presentation, associated complications, and treatment measures. In this chapter, we will cover each of these points, with somewhat more emphasis on methicillin‐resistant S. aureus that is prevalent in both community and hospital settings and is more commonly associated with worsening prognosis and higher mortality.",signatures:"Dima Youssef and Kate Molony",downloadPdfUrl:"/chapter/pdf-download/53377",previewPdfUrl:"/chapter/pdf-preview/53377",authors:[{id:"190397",title:"Dr.",name:"Dima",surname:"Youssef",slug:"dima-youssef",fullName:"Dima Youssef"},{id:"195814",title:"Dr.",name:"Kate",surname:"Molony",slug:"kate-molony",fullName:"Kate Molony"}],corrections:null},{id:"53422",title:"Determination of Staphylococcal Phenol-Soluble Modulins (PSMs) by a High-Resolution HPLC-QTOF System",doi:"10.5772/66690",slug:"determination-of-staphylococcal-phenol-soluble-modulins-psms-by-a-high-resolution-hplc-qtof-system",totalDownloads:1396,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Phenol‐soluble modulins (PSMs) are multifunctional, amphipathic, α‐helical peptides produced by virtually all staphylococcal strains. They have recently drawn much attention owing to the key contribution of some PSM peptides to staphylococcal virulence, in particular in highly virulent Staphylococcus aureus. High concentration of PSMs may cause cytolysis, damaging neutrophils, immune cells, red blood cells and white blood cells. Furthermore, all PSMs contribute to biofilm structuring and the dissemination of biofilm‐associated infection. Here we describe a method for PSM analysis in S. aureus by high‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry system (HPLC‐QTOF).",signatures:"Xiaoxiao Wu and Chi Zhang",downloadPdfUrl:"/chapter/pdf-download/53422",previewPdfUrl:"/chapter/pdf-preview/53422",authors:[{id:"190231",title:"Dr.",name:"Chi",surname:"Zhang",slug:"chi-zhang",fullName:"Chi Zhang"},{id:"194962",title:"Ms.",name:"Xiaoxiao",surname:"Wu",slug:"xiaoxiao-wu",fullName:"Xiaoxiao Wu"}],corrections:null},{id:"52584",title:"PCR Assay for Detection of Staphylococcus aureus in Fresh Lettuce (Lactuca sativa)",doi:"10.5772/65559",slug:"pcr-assay-for-detection-of-staphylococcus-aureus-in-fresh-lettuce-lactuca-sativa-",totalDownloads:1909,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The growth in food demand and production growth of vegetables have led to the development of intensive production systems with the aim of having regular access to enough high‐quality food. The aim is to determine the incidence of Staphylococcus aureus in fresh lettuce by PCR in order to enhance the efficiency for detection and identification process. The Baird‐Parker method was used for isolating pathogens from 54 lettuce samples. Genomic DNA extraction was performed according the Mericon DNA Bacteria Plus Kit. The detection by PCR was performed using the pair of primers: coa gene (5′‐ATAGAGCTGATGGTACAGG‐3′ and 5′‐GCTTCCGATTGTTCGATGC‐3′). The phylogenetic tree was constructed by comparing conserved sequences from the adjacent 16S gene, using the F2C 5′‐AGAGTTTGATCATGGCTC‐3′ and C 5′‐ACGGGCGGTGTGTAC‐3′ primers. To test the antimicrobial effect, we used the disk diffusion method (Kirby‐Bauer) using Mueller‐Hinton agar and five antibiotics with different concentrations. The incidence of S. aureus was 1.7%. All the isolates were situated in the ATCC 11632 clade in accordance with other reported sequences belonging to this pathogen in the NCBI database. All the isolates seemed to be resistant to penicillin (10U). The molecular techniques used in this study are suitable for the identification of S. aureus isolated from lettuce, increasing our capability of detecting this pathogen by improving the process and increasing the efficiency contributing to the safety of this vegetable.",signatures:"Andrés F. Chávez‐Almanza, Jaime López‐Cervantes, Ernesto U.\nCantú‐Soto, Dalia I. Sánchez‐Machado and Olga N. Campas‐Baypoli",downloadPdfUrl:"/chapter/pdf-download/52584",previewPdfUrl:"/chapter/pdf-preview/52584",authors:[{id:"190200",title:"Dr.",name:"Jaime",surname:"López-Cervantes",slug:"jaime-lopez-cervantes",fullName:"Jaime López-Cervantes"},{id:"195405",title:"Ph.D. Student",name:"Andres",surname:"Chavez Almanza",slug:"andres-chavez-almanza",fullName:"Andres Chavez Almanza"},{id:"195406",title:"Dr.",name:"Ernesto",surname:"Cantú-Soto",slug:"ernesto-cantu-soto",fullName:"Ernesto Cantú-Soto"}],corrections:null},{id:"52900",title:"Prevention of Staphylococcus aureus Contamination on Animal Products Using Indonesian Natural Products",doi:"10.5772/66045",slug:"prevention-of-staphylococcus-aureus-contamination-on-animal-products-using-indonesian-natural-produc",totalDownloads:1565,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Foodborne transmission of pathogenic microorganisms has been recognized as an important hazard. One of foodborne pathogens that was well known for 30 years, that associated with animals, have presented as illness-causing agents in humans, is Staphylococcus aureus. S. aureus is a bacterium that produces enterotoxin, causing poisoning to humans. These bacteria are found in foods that contain high protein such as sausage, eggs, meat, beef, poultry products, and milk products. S. aureus is a Gram-positive bacterium that is an indicator of contamination from the worker and tools. S. aureus contamination on raw animal products such as eggs, raw beef, and poultry products also milks in Indonesia has been reported by many researchers. Indonesia is a tropical country that has high humidity, heavy rain, and two seasons (dry and wet) that contribute to S. aureus contamination especially in animal products. Furthermore, poor postmortem handling on animal products also causes the contamination. Preventive methods are needed for food processing and food storage especially for animal products in Indonesia. This chapter in this book explains the contamination of S. aureus in animal products in Indonesia and the preventive methods used in Indonesia to reduce the contamination. Plant extracts, herbs, spices, bacteriocins, and lactic acid bacteria have been widely used in food processing in Indonesia that proved as biopreservatives for animal products.",signatures:"Irma Isnafia Arief",downloadPdfUrl:"/chapter/pdf-download/52900",previewPdfUrl:"/chapter/pdf-preview/52900",authors:[{id:"189540",title:"Dr.",name:"Irma Isnafia",surname:"Arief",slug:"irma-isnafia-arief",fullName:"Irma Isnafia Arief"}],corrections:null},{id:"52875",title:"Bacteriophage Therapy: An Alternative for the Treatment of Staphylococcus aureus Infections in Animals and Animal Models",doi:"10.5772/65761",slug:"bacteriophage-therapy-an-alternative-for-the-treatment-of-staphylococcus-aureus-infections-in-animal",totalDownloads:1988,totalCrossrefCites:4,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Staphylococcus aureus causes hospital-acquired (HA), community-acquired (CA) and companion animal and livestock-associated (LA) infections. Molecular epidemiology studies suggest that although host specificity may be associated with specific genetic lineages, recent human-to-animal and animal-to-human transmissions related to mobile genetic elements have been described. Gene transfers include virulence and antibiotic resistance genes, thus making it difficult to control multidrug resistance S. aureus infections. Bacteriophages (phages) and endolysins, the enzymes responsible for bacterial lysis by phages, are alternatives to the use of antibiotics for the control of S. aureus infections. In this work, we review current advances in the development of phage therapy and the study and design of recombinant endolysins to treat S. aureus infections. Preliminary results of bacteriophage isolation based on molecular epidemiology knowledge show that bacteriophages are specific of genetic lineages and that this strategy may be used as an approach to isolate and evaluate new bacteriophages for therapy.",signatures:"Claudia I. Barrera-Rivas, Norma A. Valle-Hurtado, Graciela M.\nGonzález-Lugo, Víctor M. Baizabal-Aguirre, Alejandro Bravo-Patiño,\nMarcos Cajero-Juárez and Juan J. Valdez-Alarcón",downloadPdfUrl:"/chapter/pdf-download/52875",previewPdfUrl:"/chapter/pdf-preview/52875",authors:[{id:"191123",title:"Dr.",name:"Juan José",surname:"Valdez-Alarcón",slug:"juan-jose-valdez-alarcon",fullName:"Juan José Valdez-Alarcón"},{id:"195005",title:"Mrs.",name:"Claudia Ibeth",surname:"Barrera-Rivas",slug:"claudia-ibeth-barrera-rivas",fullName:"Claudia Ibeth Barrera-Rivas"},{id:"195006",title:"MSc.",name:"Norma Anahí",surname:"Valle-Hurtado",slug:"norma-anahi-valle-hurtado",fullName:"Norma Anahí Valle-Hurtado"},{id:"195007",title:"MSc.",name:"Graciela M.",surname:"González-Lugo",slug:"graciela-m.-gonzalez-lugo",fullName:"Graciela M. González-Lugo"},{id:"195008",title:"Dr.",name:"Víctor Manuel",surname:"Baizabal-Aguirre",slug:"victor-manuel-baizabal-aguirre",fullName:"Víctor Manuel Baizabal-Aguirre"},{id:"195009",title:"Dr.",name:"Alejandro",surname:"Bravo-Patiño",slug:"alejandro-bravo-patino",fullName:"Alejandro Bravo-Patiño"},{id:"195010",title:"Dr.",name:"Marcos",surname:"Cajero-Juárez",slug:"marcos-cajero-juarez",fullName:"Marcos Cajero-Juárez"}],corrections:null},{id:"52755",title:"Bee Products and Essential Oils as Alternative Agents for Treatment of Infections Caused by S. aureus",doi:"10.5772/65978",slug:"bee-products-and-essential-oils-as-alternative-agents-for-treatment-of-infections-caused-by-s-aureus",totalDownloads:1916,totalCrossrefCites:4,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Bacteria of the genus Staphylococcus are important human and veterinary pathogens. A crucial characteristic for this group of bacteria is that they can easily acquire mechanisms of antibiotic resistance for a plethora of antibiotics currently in use for human and animal therapies. Therefore, there is a great need to find novel, non-antibiotic chemotherapeutics with marked antistaphylococcal activity. Promising but still underestimated group of potential antistaphylococcal chemotherapeutics constitute bee products: honey, pollen, royal jelly, fermented pollen and especially propolis. Another group of natural products that exhibit promising antibacterial activity is essential oils. Usefulness of bee products and essential oils in the treatment of infections caused by S. aureus has been confirmed by results of many investigations carried out by researches in different regions of the world. In this chapter, we have presented the review of publication in this area as well as perspectives and limitations of future applications of these two groups of natural products.",signatures:"Piotr Szweda and Barbara Kot",downloadPdfUrl:"/chapter/pdf-download/52755",previewPdfUrl:"/chapter/pdf-preview/52755",authors:[{id:"117528",title:"Dr.",name:"Szweda",surname:"Piotr",slug:"szweda-piotr",fullName:"Szweda Piotr"},{id:"189685",title:"Associate Prof.",name:"Barbara",surname:"Kot",slug:"barbara-kot",fullName:"Barbara Kot"},{id:"195004",title:"Dr.",name:"Barbara",surname:"Kot",slug:"barbara-kot",fullName:"Barbara Kot"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5831",title:"Clostridium Difficile",subtitle:"A Comprehensive Overview",isOpenForSubmission:!1,hash:"fabbec5ed99960d2fb904f16790e8b97",slug:"clostridium-difficile-a-comprehensive-overview",bookSignature:"Shymaa Enany",coverURL:"https://cdn.intechopen.com/books/images_new/5831.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6045",title:"The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus",subtitle:null,isOpenForSubmission:!1,hash:"4f24bfdcb5cd606846da63b96000bed2",slug:"the-rise-of-virulence-and-antibiotic-resistance-in-staphylococcus-aureus",bookSignature:"Shymaa Enany and Laura E. 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The present book intends to provide the reader with a comprehensive overview of the state of art in beauty and attraction studies, by using a multidisciplinary approach and incorporating different points of view, from evolution and biology to culture and arts. The chapters in this book will cover topics including evolutionary approaches to aesthetics and attractiveness, the influence of beauty in the understanding of the outside world, and how it influences our social and interpersonal decision makings, cross-cultural similarities and differences in attractiveness perception and preferences, aesthetics in visual arts, as well as, beauty as supernormality.
",isbn:"978-1-83768-326-0",printIsbn:"978-1-83768-325-3",pdfIsbn:"978-1-83768-327-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"8f2773e5d4ffe767f38dd15712258e8c",bookSignature:"Dr. Farid Pazhoohi",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11436.jpg",keywords:"Facial Attractiveness, Bodily Attractiveness, Mate Choice, Sexual Dimorphism, Evolved Perceptual Preferences, Darwinian Aesthetics, Shape and Texture, Facial Preferences, Bodily Preferences, Supernormal Stimuli, Cosmetics, Plastic Surgery",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 7th 2022",dateEndSecondStepPublish:"July 5th 2022",dateEndThirdStepPublish:"July 29th 2022",dateEndFourthStepPublish:"October 17th 2022",dateEndFifthStepPublish:"December 16th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A researcher in the fields of cognitive, neuro, and social psychology, affiliated with the University of British Columbia, and Associate Editor for Frontiers in Psychology.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"470837",title:"Dr.",name:"Farid",middleName:null,surname:"Pazhoohi",slug:"farid-pazhoohi",fullName:"Farid Pazhoohi",profilePictureURL:"https://mts.intechopen.com/storage/users/470837/images/system/470837.png",biography:"Farid Pazhoohi (Ph.D.) is an interdisciplinary researcher and his research program focuses on the cognitive, social, and neural mechanisms of physical attractiveness, and how attention, perception, decision making, social cognition, and interpersonal interactions are influenced by aesthetics and attractiveness.",institutionString:"University of British Columbia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"21",title:"Psychology",slug:"psychology"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"347259",firstName:"Karmen",lastName:"Daleta",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"karmen@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6494",title:"Behavior Analysis",subtitle:null,isOpenForSubmission:!1,hash:"72a81a7163705b2765f9eb0b21dec70e",slug:"behavior-analysis",bookSignature:"Huei-Tse Hou and Carolyn S. Ryan",coverURL:"https://cdn.intechopen.com/books/images_new/6494.jpg",editedByType:"Edited by",editors:[{id:"96493",title:"Prof.",name:"Huei Tse",surname:"Hou",slug:"huei-tse-hou",fullName:"Huei Tse Hou"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9052",title:"Psychoanalysis",subtitle:"A New Overview",isOpenForSubmission:!1,hash:"69cc7a085f5417038f532cf11edee22f",slug:"psychoanalysis-a-new-overview",bookSignature:"Floriana Irtelli, Barbara Marchesi and Federico Durbano",coverURL:"https://cdn.intechopen.com/books/images_new/9052.jpg",editedByType:"Edited by",editors:[{id:"174641",title:"Dr.",name:"Floriana",surname:"Irtelli",slug:"floriana-irtelli",fullName:"Floriana Irtelli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10981",title:"Sport Psychology in Sports, Exercise and Physical Activity",subtitle:null,isOpenForSubmission:!1,hash:"5214c44bdc42978449de0751ca364684",slug:"sport-psychology-in-sports-exercise-and-physical-activity",bookSignature:"Hilde G. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"69072",title:"Saving Time in Portfolio Optimization on Financial Markets",doi:"10.5772/intechopen.88985",slug:"saving-time-in-portfolio-optimization-on-financial-markets",body:'\nThe time management is important part for tasks in real time operation of systems, automation systems, optimization in complex system, taking explicit consideration in time constraints, scheduling of tasks and operations, making with incomplete data, time management in different practical cases. The limits in time for taking appropriate decisions for management and control is a strong constraints for the implementation of autonomic functionalities as self-configuration, self-optimization, self-healing, self-protection in computer systems, transportation systems, distributed systems. Time is an important and expensive resource.
\nThe time management in financial domain is a prerequisite for high competitiveness and increase of the quality of the investment activities. It is the popular phrase that “time is money” and particularly the portfolio optimization targets its implementation in real cases. This research targets the identification of portfolio parameters, which are strongly influenced by time. We restrict our considerations only on portfolio optimization task and we identify cases, which are strongly influenced by time constraints. Thus, the portfolio optimization problem is discussed on position how the time can influence the portfolio characteristics and solutions. This chapter starts with description of the object “portfolio management” which provides the cases where time in explicit way influences the portfolio problem.
\nThe task, which is resolved by the portfolio optimization of financial resources, is related with maximization of the return and simultaneously minimization of the investment risk. The portfolio optimization can be applied also to assets, which belong to the stock markets, because the same valued characteristics are used for portfolio optimization. The goal of the portfolio problem is to share the amount of investments among a set of securities, which are chosen to enter into the portfolio. The portfolio goal is to allocate in optimal manner the parts of the investment for buying securities. The time management problem initially arises with its complexity on the stage of the portfolio definition. The investment procedure has to be implemented at time
Time schedule of the portfolio investment.
The portfolio management insists to make decision for buying (or selling) assets at the current time
The value of the
Following (2) for the implementation of the portfolio investment, the investor has:
to choose the types and number of assets
to assess the assets’ characteristics
to choose the duration ∆
to forecast the assets’ characteristics
to define and solve the portfolio optimization problem which will give the relative weights
and
The Modern Portfolio Theory (MPT) was quantitatively introduced from Markowitz, with his seminal work [1]. The problems, introduced for the portfolio optimization are defined with two formal descriptions:
maximization of portfolio
\n
and/or minimization of portfolio
The notations used concern
\n\n\n
Particularly, additional nonnegative constraints are aided,
To be able to solve problems (4) and (5) the parameters
where \n
Having the values
The covariance coefficient
Graphical interpretation of the risk and mean return of asset.
\n\n
The risk of the asset graphically represents the diapason [\n
The value of the portfolio risk is calculated by the quadratic term
\nThe MPT uses and integration of the portfolio problems (4) and (5) by definition of a common optimization problem
\nThe value of \n
For the case \n
For the case \n
By changing \n
The curve of “efficient frontier” and the market point.
The efficient frontier has quadratic character but it is not a smooth line [3]. This non-smooth character origins from the existence of non-negative constraints
the portfolio manager has to choose the time for the portfolio implementation;
he has to decide the duration of the investment ∆
he has to choose the duration
Thus, the time is very important parameter, which influences the definition and implementation of the portfolio investment and optimization.
\nThe MPT originated by the works of Markowitz has its further developments. The next important stage of MPT is the definition of the Capital Market Theory, [2]. The Capital Market Theory introduces a new point on the “efficient frontier,” named “market portfolio.” It has analogical portfolio characteristics as market return \n
The graphical representation of the CML is given in Figure 3. It starts from the point (0,\n
By estimating the market parameters \n
The SML introduces linear relations between the mean return of a particular asset \n
The coefficient “beta” (\n
The “beta” coefficient takes normalized values from the diapason [−1, 1]. Numerically, it defines how strong the mean return value \n
The HL line makes additional clarification between the current value of the asset return
Relation (15) is timely influenced. If the market value
The CAPM does not apply explicit inclusion of time in its characteristics. Time explicitly influences only the values of the market return \n
The Black-Litterman (BL) model is based on both achievements of the MV portfolio model and CAPM. The idea behind the BL model is the ability to use additional information by means to estimate and to predict the assets’ characteristics
Additional modification of portfolio parameters by BL model.
The MV model estimates the assets characteristics
The BL model added a new contribution to the MPT by introducing new characteristic of the portfolio asset: “implied return,” \n
where the noise \n
where
The goal of the BL model is the evaluation of the returns \n
Using [8, 9] the assumption is made that the “implied excess return”
where \n
By multiplication from left of the both sides of (20) with market capitalization weights \n
The right component of (21) contains the market “excess return” \n
Substituting (22) in (21) the “implied excess return” results as
\nThe “implied return”
This manner of definition of
Following [10] absolute and relative manner for the formalization of the expert views are applied. The explanation of these forms of formalization is given with a simple example. Let’s the portfolio contains
The relative form of views applies comparisons between the assets’ returns. Let’s the first expert expects that the first asset will outperform the third one with 2.5%; the second expert makes view that the second asset will outperform the fourth one with 3.5%. The formalization of matrices
The two types of formalization of expert views is widely mention in references dealing with the BL model [7, 10]. A new form of expert views has been developed in [11]. It has been applied a weighted form for the definition of matrix
Hence it follows
\nwhere \n
Relations (29) have analytical structure with the risk relation of portfolio with two assets,
The comparisons between relations (29) and (30) can be interpreted that in (29) \n
Now let’s assume that the matrix
For that case the corresponding values of the components \n
Relations (32) interpret that for the weighted form
This research makes several additions to the numerical definition of
1. Formalization P
Following [11] a row of matrix
Relation (33) presents that the mean history’ return of asset
Asset
The value of the component from matrix
\n
2. Formalization P
For that case relations (33) and (34) are slightly modified with lack of volatility normalization
\n
3. Formalization of
\n
4. A particular case can arise when all differences \n
For that case absolute views can be assign. The matrix
Thus, for the formalization of p. 2 the matrices
for the case of p. 3. These four forms of weighted formalization of matrix
Using relations (22) and (23) the BL returns
where
\nThe general least square method with the minimization of the Mahalanobis distance
\ngives solution
\nand volatility \n
Taking into account the riskless return, the final BL assets’ returns and covariance matrix are
\nUsing these modified assets’ characteristics, the portfolio problem (11) is solved and appropriate point from the efficient frontier is chosen. It is recommended the best portfolio to be taken with weights \n
The numerical simulations are performed with real data from the Bulgarian Stock Exchange [12]. The riskless investment for several years gives very low or even negative return. That is, the reason for the investors to start to apply portfolio optimization with risky assets. Currently, the risky investments are performed with a set of about 125 mutual funds in Bulgaria nowadays. The mutual funds are operated by different business and economics entities. The goal of all mutual funds is to manage their portfolios by means to achieve positive return or to decrease the losses in nonfriendly behavior of the financial market. The success or not successful management of the mutual funds can be seen by their historical data about achieved returns and risks in their investments. Thus, our portfolio simulations will start with historical return data of a set of chosen Bulgarian mutual funds. It has been chosen seven mutual funds to participate in the portfolio: Concord Asset Management (CONCORD), Elana Asset Management (ELANA), Profit Asset Management (PROFIT), Texim (TEXIM), Central Cooperative Bank Lider (LIDER), Asset Management UBB Patrimonium (PATRIM), Asset Management DSK Growth (GROWTH). They invest both in currencies and shares. The Bulgarian Association of Asset Management Companies [13] and the Government Financial Supervision Commission [14] regularly record and update the activities of the Bulgarian mutual funds. For the simulation experiments it has been taken the mean monthly return of these 7 mutual funds for 2018-year, Figure 5.
\nMonthly and annual returns, and the covariance matrix of the mutual funds for 2018.
The calculations in this research have been performed in MATLAB environment. The mean years returns and the covariance matrix are given also in Figure 5. The simulations apply multiperiod investment policy, described in Figure 6.
\nMulti period investment with flowing historical window.
The monthly mean returns of the mutual funds for the first 8 months of 2018 were taken as historical period. It has been calculated the average return for each fund for this historical period,
Mean returns and covariance matrix for the first 8 months of 2018.
The portfolio manager has to pay attention for the different values of mean returns and covariance, given in Figures 5 and 7. The first case is evaluated for
By changing the values of \n
Graphical presentation of the “efficient frontier” with historical data.
The Sharpe excess ratio (45) and the information ratio (46) are presented in Figure 9.
\nGraphical presentation of Sharpe excess ratio and information ratio.
It is estimated the maximum Sharpe_excess_ratio = 4.321. This value corresponds to a portfolio with characteristics:
\nThese results recommend that the portfolio manager has to allocate his investment only in two mutual funds: the second in the portfolio (ELANA) and the third one (PROFIT). This recommendation is valid for the investment month of September 2018.
\nIn this research for the risk-free return
The characteristics of the market point are the mean return
where
The numerical values of the market point are:
\nThe graphical presentation of the CML, the “efficient frontier” and its approximation and the market point are given in Figure 10.
\nCML and approximated efficient frontier.
Using relation (23) the “implied excess returns”
Respectively, the “implied returns” is
The portfolio parameter, which is used for the estimation of matrices
Because the value of the third component of
The evaluations of the modified mean assets’ returns
The portfolio problem (11) is repetitively solved by changing \n
Efficient frontiers with MV and BL models.
The portfolio which has maximum Sharpe excess ratio is identified. This maximum is found from the numerically evaluated points of the BL “efficient frontier.” The needed portfolio parameters are stored in the arrays in MATLAB, during the sequential solutions of problem (11). The Sharpe excess ratio evaluated from (45) gives:
\nThe difference between \n
The optimal weights \n
For the case when the MV weights
\n
For the case when \n
Then these portfolio results will be compared in the space
Following Figure 6 a next portfolio investment with MV and BL models is done by moving the history period 1 month ahead. The portfolio evaluations are done for a history period from February till September 2018. The evaluated weights \n
For the cases when all components
MV model | \nBL model | \n||||||
---|---|---|---|---|---|---|---|
P(\n | \nP(\n | \nP(\n | \n|||||
0.1080 | \n0.0133 | \n0.1017 | \n0.0132 | \n0.1055 | \n0.0132 | \n0.1122 | \n0.0129 | \n
−0.0187 | \n0.0117 | \n−0.0931 | \n0.0120 | \n−0.0632 | \n0.0111 | \n−0.0221 | \n0.0106 | \n
−0.4011 | \n0.0282 | \n−0.3861 | \n0.0263 | \n−0.3793 | \n0.0255 | \n−0.4088 | \n0.0292 | \n
−0.3525 | \n0.0240 | \n−0.2313 | \n0.0114 | \n−0.1523 | \n0.0080 | \n−0.2028 | \n0.0106 | \n
Results of multi-period portfolio management with MV and BL models.
The graphical presentation of the comparison of the multiperiod portfolio management between MV and BL with
Comparison of multiperiod MV and BL(P(П)) portfolio optimization.
The common results prove that the market situation in 2018 does not allow the mutual funds to achieve positive return. The results are negative but this negative value is less than the riskless return value
This research illustrates that the task of portfolio investment is quite complicated. The meaning of portfolio optimization concerns the definition and solution of portfolio problem. In both these tasks the time is a prerequisite for successful portfolio investment.
\nThe content in the paragraph “Portfolio optimization problem” explicitly asserts that the investor has to choose the duration of the historical period. This duration,
The active management needs to follow the current dynamics of the market. The relations between
An unexpected problem has been met by the authors, concerning the relation between the historical discrete points
The solution of the portfolio problem (11) gives unique set of weights, which have to be implemented for the portfolio investment. Because the market behavior changes, reasonable policy is to perform repeatedly definition and solution of the portfolio problem. Potential beneficial strategy can be the multiperiod portfolio management, presented in Figure 6. It incorporates the multiperiod management and adopts the portfolio parameters with up to date market data. The relation between the duration of the historical period and the investment period is still an open question. But making additional simulations with 1, 2, 3 or more months (time) ahead the portfolio manager can change his decision on each investment step.
\nThis research identifies in explicit way the influence of the time for the definition and solution of portfolio problems. These time requirements are considerably related with the estimation of the parameters of the portfolio problem. Respectively, the time requirements insist the portfolio management to be performed in multiperiod investment.
\nThis research makes an analysis of the development of the portfolio theory. Starting with the Markowitz formalization, the MV portfolio problems are based only on historical data about mean returns and covariances between the returns. The development of CAPM gives new relations, originated from a new “market” point. The last gives additional information about the values of the parameters of the portfolio problem. Finally, the BL model introduces a new set of points, “implied excess returns,” which originate from the market point. As a result, new values for the parameters of the portfolio problem are found. Respectively, the portfolio problem gives weights of the assets, which are not sharp cut, which decreases the risk of the investment.
\nThis research introduces new modifications of the BL model for the part of definition of expert views. Particularly the experts are substituted by additional data, which origins from the dynamical behavior of the assets’ returns. Thus, not only mean returns and covariances are taken into consideration, but also the difference between objective parameters as implied and historical mean returns. These modifications allow the portfolio model MV and these based on BL one to be compared on a common basis and to assess their performances. Such comparison cannot be made if subjective experts are used, because their mutual views will be different for the same historical data and with changes the members of the experts.
\nThis research gives also a practical added value with the analysis of the behavior of the market with mutual funds in Bulgaria. This gives additional experience and bases for future comparisons and assessments of the different portfolio models.
\nThis work has been partly supported by project H12/8, 14.07.2017 of the Bulgarian National Science fund: Integrated bi-level optimization in information service for portfolio optimization, contract ДH12/10, 20.12.2017.
\nThe provision and efficient delivery of high-quality real-time streaming services, such as Internet protocol television (IPTV) over wireless networks (e.g., Wi-Fi) in the last mile, introduces never-ending challenges. Easy and fast deployment and relatively low deployment costs of Wireless IEEE 802.11 networks, where one antenna covers several different clients/groups of clients, stimulate the usage of Wi-Fi technology in underdeveloped countries and rural areas. However, the bottleneck in the content delivery is due to spectrum limitations in wireless medium shifted to the last mile. Thus for ISPs, it is of paramount importance to increase the last mile access performance as in such cases, the bandwidth reduction means better services for existing clients, or alternatively, additional clients over the same infrastructure. Thus in this chapter, we are addressing the efficient and quality delivery of video-streaming services such as IPTV using the IEEE 802.11 wireless broadcast network in the last mile [1].
\nBy using IEEE 802.11 wireless network in the last mile, the video content can be delivered using unicast or broadcast/multicast mechanism. Due to the fact that unicast mechanism, which delivers the content to clients individually and supports retransmissions (and back off) that assure reliable content delivery, is a preferred solution in currently deployed systems. On the other hand, multicasting can be used instead of unicasting in order to reduce the bandwidth. The bandwidth can be significantly reduced in particular, when multiple clients watch the same video stream, as the server, instead of sending multiple packets to different clients, has to send only one packet. All broadcast packets are delivered to all clients only under ideal wireless channel conditions. However, the packet losses frequently occur in the practical wireless environment; thus, some sort of retransmission mechanism is necessary to ensure reliability. In order to support reliability and/or reduce bandwidth consumption, different retransmission schemes have been proposed, where some of them also consider network coding (NC).
\nSince the pioneering work in network coding [2], numerous papers appeared on this subject and significant progress has been made in applying NC to different networks. NC has already been successfully used to increase throughput as shown in practical deployment in [3], where a reliable and scalable live streaming solution is presented. It is based on wireless multicast with real-time network coding in hyper-dense Wi-Fi spaces. A timely delivery scheme that uses a minimum amount of feedback from the clients is at the core of this approach. It generates coded repair packets, which are useful to a large number of clients. Packet loss estimation is used in the scheme, which is able to operate well with a very limited amount of feedback. Besides, all coded packets are linear combinations of original packets over the Galois field of size 2. Nevertheless, they are focusing on satisfying different clients’ requests regarding the same flow, while we are focusing on satisfying different clients regarding different flows, using different approach of NC and feedbacks.
\nIn [4], for the particular case of wireless mesh network, a network coding and scheduling scheme for transmitting several video streams over a wireless mesh network is proposed. Their main outcome is that in a network coding capable wireless network, the transmission of video streams should be optimized also, and even more important than for network throughput, for video quality. All approaches mentioned in [4, 5, 6] are designed for intersession network coding, by combining different flows. They compute a packet that must be decoded by the next hop of the head of the sender’s output queue, based on a first in first out (FIFO) management for the requests of each client. However, there is no such restriction in our proposal and all client requests are taken into consideration, which significantly changes the complexity and the nature of the coding problem.
\nRetransmission schemes based on NC are discussed in [7, 8, 9]. Their key idea, in order to combine different lost packets with network coding to achieve retransmission, is to use the feedback of lost packets information. Their approaches by broadcasting combined packets effectively save the number of transmissions and advance the efficiency of transmissions. However, in practical real-time streaming applications, those approaches have their own drawbacks and limitations.
\nDepending on the NC application, the implementation affects different open systems interconnection (OSI) layers. In this chapter, we propose transmission scheme that is integrated in the application layer and is adapted for video-streaming applications such as IPTV. It can be used for increasing network throughput of mobile and static wireless networks. We also evaluate its performance using practical Wi-Fi test bed that comprises a streaming server and multiple Wi-Fi clients.
\nThe rest of the chapter is organized as follows. In this section, we introduced the video-streaming challenges in wireless medium using IPTV. Section 2 discusses the packet loss recovery techniques in streaming wireless networks. Section 3 proposes concept of transmission scheme for reliable video-streaming service using network coding and gives an overview about implementation details. Practical evaluation of the proposed solutions is described in Section 4, and finally, Section 5 concludes the chapter.
\nThe main advantages of wireless networks over wired counterparts include ease of deployment and mobile clients support. However, the unique characteristics of video data amplify the difficulty of video transmission and thus impose a number of challenges. Some of the main challenges of wireless networking and their impact on video communication are discussed and highlighted in the following.
\nShadowing and multipath fading: they are common wireless effects. Shadowing is caused by obstacles between the transmitter and the receiver that attenuate signal power through absorption, reflection, scattering, and diffraction. It occurs over a relatively large time scale. On the other hand, multipath fading is due to multipath propagation: different path signals are added constructively or destructively. Multipath fading results in rapid fluctuation of signal amplitude within the order of a wavelength. The presence of shadowing and multipath fading results in time-varying channel conditions and location-dependent packet erasures. They cause burst errors in the form of multiple lost packets.
Limited bandwidth: wireless networks are limited in capacity. Although, the 802.11 products are advertised as having a high data rate. Still, “protection” mechanisms such as binary exponential back off, rate adaptation, and protocol overheads cut the throughput by 50% or more. Moreover, due to the shared nature of the wireless medium, the actual bandwidth available to individual clients can even be much lower, posing a great obstacle for providing high bandwidth video services.
Interference: wireless medium is shared among multiple clients; thus signals, which arrive at a receiver from other concurrent transmissions, although attenuated, cause the interference for the receiver. It is a common effect in WLANs because they operate in the unlicensed 2.4/5 GHz industrial, scientific, and medical (ISM) frequency band. Interference affects the quality of a wireless link, and consequently, its error rate and achievable capacity.
Video services and applications have become the driving force in the development and widespread deployment of wireless broadband access technologies and high speed local area networks. Convenient and cable-free connectivity can be achieved by using wireless local area networking (WLAN) technologies. Using the wireless networks, it also can provide mobility to portable TVs.
\nAs conventional service architectures, network structures and protocols have not been designed to consider the high data rate and real-time transmission requirements of digital video, they lack to provide a robust medium distribution.
\nVideo-streaming applications have distinctive QoS requirements, such as high bandwidth requirement, delay sensitiveness, and loss tolerance. We list the challenging QoS issues as follows:
\nBandwidth: transmission of video sequences typically has a minimum bandwidth requirement in order to achieve acceptable presentation quality. Therefore, supporting the delivery of video over time-varying wireless links could be very unreliable. The challenge lies in keeping the quality degradation to a level that is hardly noticeable or tolerable while utilizing the wireless resources efficiently.
Delay: in contrast to data transmission, which is usually not subjected to strict delay constraints, video-streaming requires bounded end-to-end delay. Each video frame needs to arrive at the client to be decoded and displayed, before its play out deadline. Otherwise, it is useless. If the video packet does not arrive on time, the play out process will have to be temporally paused, which is annoying to human eyes and deteriorates the overall streaming quality. Consequently, video-streaming applications are usually known to be very sensitive to delay.
Packet loss: video-streaming technology is tolerant to a certain level of loss, since the visual quality will still be acceptable if the packet loss ratio is kept below a certain threshold. However, loss of packets can potentially make the presentation displeasing to human eyes, especially when some of the key video frames are lost, which could make the presentation impossible.
Unreliability: Wi-Fi does not provide a retransmission mechanism for broadcast/multicast transmissions (with multiple clients). Wi-Fi multicast traffic could normally experience a packet loss rate of 5%. As a loss of even a single video packet can result as an error that propagates for many video frames, this is a serious problem. Thus, it is quite normal that multicast video applications fail completely when they operate on a Wi-Fi network although they work fine on a wired network.
Internet protocol television (IPTV) is a system that is used to deliver the Internet television services across the Internet protocol (IP) infrastructure. IPTV integrates voice, video, and data delivery into a single IP framework, to enable interactive broadcasting services to the subscribers. It promises significant advantages for both service providers and clients.
\nIn the past few years, IPTV has gained an unremarkable growth rate. IPTV services are becoming very popular among telecommunication companies, most of all because they can provide television programs anytime and anywhere. IPTV can support broadcast and unicast services, such as broadcasting of TV channels, Video on demand (VoD) or time-shifted television. Unlike conventional broadcasting systems, IPTV broadcasts will not be restricted by the limited number of channels in the broadcast/radio spectrum.
\nBesides, IPTV will provide its clients with the opportunity to access and interact with a wide variety of high quality on demand video content over the Internet. Since IPTV is considered as a real-time broadcast service over the Internet, the success of the IPTV service depends on the quality of experience (QoE) perceived by the end clients.
\nThe IPTV system has to support a wide range of transmission channel characteristics (i.e., varying packet loss rates and transmission delays) between the content providers and the end clients. The characteristics of video traffic as well as the high-quality requirements of IPTV broadcast impose strict requirements on transmission delay. IPTV framework has to provide mechanisms to satisfy the stringent delay, jitter, and bandwidth requirements over lossy transmission channels.
\nThe architecture of IPTV is composed of five main parts as depicted in Figure 1: (i) head network, (ii) core network, (iii) distribution network, (iv) access network, and (v) customer network.
\nIPTV architecture.
Transport network includes the core network, distribution network, and access network. IPTV service provider transports the IPTV streams to client end by using all entities of the transport network. Among all these entities, major bandwidth restricting entity in transport network is the access point (AP) because of limited buffer size of queues. To avoid bandwidth restriction, wired access links such as cable and digital subscriber line (DSL) are preferred by IPTV service providers.
\nUsing WLAN for IPTV distribution improves the mobility and flexibility of IPTV network deployment; however, it has its challenges as described in previous sections and it can impact the clients’ quality of experience when watching an IPTV program.
\nError correction schemes such as forward error correction (FEC) and/or retransmissions can be used to improve reliability of an IPTV program. Both of them are explained in more detail below.
\nConsidering the earlier mentioned strict quality requirements of video, strong error recovery techniques are required to protect the content that is delivered to end clients and recover from the occasional packet losses. As it can be seen from the previous examples, there are two possibilities either to prevent packet loss or, alternatively, when packet loss does happen, reduce the noticeable effects of packet loss or restore the missing packets.
\nIn other words, one wants to provide a mechanism to recover from packet loss or to have an error resiliency mechanism that reduces errors due to packet loss. Numerous techniques for providing error resiliency against packet loss can be divided in two categories:
\nTechniques that provide recovery for packet loss.
Techniques that try to reduce the impact or effect of the packet loss.
Two different techniques aimed to recover packet losses during the delivery of IPTV services are FEC and retransmission. The FEC approach operates by adding redundant information to the data at the server, while the retransmission approach recovers from packet losses by requesting retransmission from the server.
\nAn FEC-based error recovery protocol uses redundant information to allow the client to correct packet losses. With this redundant information, the clients can recover from packet losses nearby the client. The amount of data that can be reconstructed is determined by the amount of loss and on the amount of redundant data. As an FEC-based recovery mechanism is suitable in networks that only allow unidirectional traffic (e.g., satellite broadcast) or environments where the latency from the client to the server is relatively high (e.g., cellular networks), it does not require any feedback from the server to the client. It can be applied from the physical layer up to the application layer according to the OSI reference model. For IPTV streaming applications, FEC can be offered at network layer, transport layer, or application layer FEC. A disadvantage of a FEC protection mechanism is that the applied FEC protection scheme might be insufficient (too weak) for certain clients, while at the same time can be superfluous for some other clients, thus being a waste of bandwidth.
\nPacket retransmission is the technique of retransmitting packets that are considered lost. A packet retransmission requires communication between the client and server, as the client needs to explicitly or implicitly request the packet retransmissions from server. The transmission control protocol (TCP) is a well-known protocol using packet retransmission. Bi-directional communication is required at packet retransmission mechanism in order to allow the client to indicate packet loss and to identify which packet needs to be retransmitted. It is typically achieved by applying sequence numbers. To indicate the loss of packets, two types of messages can be used:
\nAcknowledgment (ACK) messages can be used to implicitly indicate the loss of a packet by acknowledging the reception of one packet or a sequence of packets. As the missing packet will never be acknowledged, these messages can then be used to implicitly determine packet loss (e.g., TCP uses ACK messages).
Negative acknowledgment (NACK) messages are used to explicitly indicate that one or more packets were not received. As feedback from client to server is kept to a minimum, NACK messages are used in constrained networks with many clients per server.
A packet retransmission mechanism is adaptive to variable network conditions. When there is no loss in the network, there will be no packet retransmission, hence no additional required bandwidth. Because packet retransmission mechanisms introduce delay, they are only suitable for applications with nonstrict delay requirements.
\nUsing packet retransmissions for (live) IPTV services has also the drawbacks as IPTV streams are not likely to get adapted to congestion. Thus, if congestion occurs during transport, the packet retransmissions may contribute to the network congestion if the packet retransmission is enabled, thus further lowering bandwidth available for IPTV stream delivery.
\nIn the past few years, network coding (NC) has become popular in both wired and wireless networks as a mechanism for increasing the network throughput. Proposed by Ahlswede et al. in [2], it is a technique for increasing the throughput of the network by encoding multiple packets into the same packet, either from the same or from different streams.
\nUsing the NC, the broadcast nature of the wireless medium is exploited. In the wireless physical medium, all data transmitted by the source is in fact inherently broadcasted to all destinations, even when it is not intended. For no extra cost, other receivers will receive packets not addressed to them. In the case where a packet is lost at the receiver, other receivers may receive it successfully. Keeping those packets by receivers for some time enables NC to reduce the number of packets to be transmitted.
\nNC reduces the number of transmissions by replacing the conventional store-and-forward paradigm in relaying scenarios with a process-and-forward approach. Instead of forwarding packets in the same form as they are received, the intermediate nodes combine the received outgoing packets using an algebraic function such as XOR. All nodes store all the received packets for possible packet decoding purposes. As a result, a typical NC mechanism is composed of two main operations [6, 10]:
\nCoding outgoing packets on intermediate nodes.
Decoding incoming packets upon their reception on nodes.
The main concept of NC is presented through examples and is also sketched in Figure 2. Let us consider the situation where destination node D1 can only hear transmissions from relay node R and source S1. Similarly, destination D2 can only hear transmissions from source S2 and relay node R. S1 has a packet p1 for D2 and S2 has a packet p2 for D1. S1 and S2 send their packets separately to R, using two transmissions. In the first example (i.e., Figure 2 (without NC)), the relay node R cannot transmit two packets at the same time. Thus, again two transmissions are used to transmit packets p1 and p2.
\nNetwork coding example.
Referring to the Figure 2 (with NC), it shows the case of the same network but using NC. The relay node R has enough processing power to code two packets, that is, the R node performs a coding operation, for example, linear operation over the p1 and p2; thus creating a coded packet of the same size as largest of p1 and p2. Node R can now by sending only one packet forward both p1 and p2 to its destination nodes. D1 can decode the coded packet as it is familiar with the content of p1 and similarly D2 can also decode coded packet as it knows the content of p2. Instead of using four transmissions, the broadcast nature of the media has been embraced and only three transmissions were needed.
\nThe slight overhead that can be seen here is the buffer space requirement as well as additional processing in encoding and decoding the packet. With the advancement in solid states like high speed processors, and high speed and large capacity memories, these overheads are well taken care of. The bandwidth is limited especially in wireless networks. Using NC, we can efficiently utilize the bandwidth of the network.
\nConsider the system setup illustrated in Figure 3. System is intended for transferring multiple video streams to multiple clients. In depicted example, streaming server is streaming two channels (streams
Retransmissions using traditional retransmission scheme.
Figure 4 shows similar system. The difference is in the retransmission concept. In the first system, every packet that has not been received is retransmitted individually (e.g., five retransmissions). The second system codes multiple packets together and generally uses fewer transmissions (e.g., three).
\nRetransmissions using NC-assisted retransmission scheme.
For the system depicted in Figure 4, the design parameters were selected as follows:
\nOnly packets that require retransmission are transmitted.
Packets are transmitted as late as possible, that is, after the retransmission timeout (RTO) or opportunistically.
All coded packets must be decodable on all the clients.
Packets not received by any of the clients are sent out as they are, that is, not coded.
The streaming server keeps track of packets received for each of the clients. Information about unsuccessful received packet is provided through the negative acknowledgement (NACK) packet. Current status of the received packets at individual clients is presented in a transition table (e.g., Table 1(a)).
(a) Transition table | \n(b) Coding table | \n||||
---|---|---|---|---|---|
\n | C1 | \nC2 | \n\n | C1 | \nC2 | \n
A1 | \n0 | \n1 | \nA1 | \n0 | \n1 | \n
B1 | \n1 | \n0 | \nB1 | \n1 | \n0 | \n
A2 | \n0 | \n1 | \nA2 | \n0 | \n1 | \n
B2 | \n2 | \n1 | \nA3 | \n0 | \n1 | \n
A3 | \n0 | \n2 | \nB3 | \n1 | \n0 | \n
B3 | \n1 | \n0 | \n\n | \n | \n |
Transition and coding tables.
Packet status is represented in the transition table for the time needed to receive feedback from all the clients as explained in next section. Transmission and coding processes are based on the coding table (e.g., Table 1(b)) that is obtained from transition table and where only packets that require retransmissions are represented. As soon as packet status is noted in the coding table, the packet can be opportunistically transmitted. In coding table, two states are used to describe the packet status of the clients. Namely, not received packet is indicated by state 0, while packet received on the corresponding client is indicated by state 1. However, in the coding table, we are not presenting the packets that do not need to be retransmitted as they were not transcript from transition to coding table.
\nIn practice, this means that all sums over the corresponding packet columns from the coding table are not less than the number of coded packets
1:
2:
3: k = 1;
\n4: coded_packets [k] = &P1;
\n5: temp_coding = coding_table [first_row];
\n6: coding = temp_coding [];
\n7:
8: codable = 1;
\n9:
10: temp_coding[n] = temp_coding[n] + coding table [m, n];
\n11:
12: codable = 0;
\n13: temp_coding = coding;
\n14: break;
\n15:
16:
17:
18: k++;
\n19: coding = temp_coding;
\n20: coded_packets [k] = &Pm
\n21:
22:
23: break;
\n24:
25:
26:
27:
28: encode packets from coded_packets
\n29: sent encoded_packet;
\n30:
31: sent P1 uncoded;
\n32:
33: update coding_table;
\n34:
In a given
This section describes implementation details of the mechanisms required on the server and client.
\nOn the client,
Packet headers.
Signalization (
In order to evaluate the proposed scheme, we deployed IEEE 802.11 network test bed consisted of streaming server, access point, and multiple Wi-Fi clients. Server and clients were laptops with different hardware, for example, different wireless interfaces. For the access point, we used wireless router Linksys WRT54GL. Server was connected to the wireless router via Ethernet interface while clients were connected via WLAN interface. In order to perform tests, we used a third party firmware (i.e., DD-WRT) in our wireless router, because the original firmware was not capable of transmitting a multicast channel through it. Wireless router configuration was fixed during the experiments. Packets size was constant (i.e., 1210 bytes). Inter-arrival time between packets was also constant (i.e., 6 ms), resembling video-streaming application. Results were presented for the shortest time intervals to observe steady state conditions. Two client setups, mobile and static were used for the evaluation and are presented in the next sections.
\nIn this scenario, experiment was set up with server and six clients, where each client position has changed once, during the experiment.
\nServer streamed one UDP 608 MB stream. If it streamed one packet every 6 ms (inter-arrival time between packets) that would be approx. 166 packets per second. The size of a single packet is 1200 bytes. Thus, the data rate was 1.525 Mbps.
\nThe experiment started with all clients placed in the room with the router. Every 7 min, one client at a time was relocated to the nearby room. By moving clients to the nearby room, we wanted to observe how delivery probabilities were changing during the time. We assumed that delivery probabilities would decrease, due to wall obstacles between the server and the clients. Further, obstacles had caused packet loss, which we supposed would affect delivery probability of single clients in the nearby room.
\nNext, with decreased delivery probabilities, we expect more coding opportunities and higher bandwidth reduction, which we will discuss later in the result section.
\nIn the second scenario, where clients were static and located in one room, four experiments were carried out, each with different number of clients (4, 6, 8, and 10). Server streamed one UDP stream in total of 122 MB and 1.525 Mbps data rate. Value of data rate is calculated as in for mobile client setup. Using this architecture setup, we wanted to observe if the number of clients will affect improvements in the bandwidth.
\nWe expect to reduce more of the bandwidth, because with more clients we assume more coding opportunities, which means fewer transmissions and therefore better bandwidth reductions.
\nSeveral performance metrics were used to evaluate the performance of the proposed scheme. All the presented results were observed over the sample period
Bandwidth reduction
Client delivery probability
Delivery probability
Client gain
Gain
Coding table size (CTS) refers to the number of packet-statuses on the clients noted in the table (note that only packet that requires retransmission is present there). Size is sampled periodically, after broadcasting native packet.
\nResults are presented individually for two client’s setups that we explained above, that is, mobile and static. Mobile client’s results give more detail results of described performance metrics above, while static client’s results just discuss the number of clients depended of the gain.
\nBandwidth reduction
Bandwidth reduction
Delivery probability
In the following, we show relations between average numbers of coded packets
Average number of coded packets CAVG, coding table size CTS, and gain
In the next step, we investigate
Gain in
We investigate how the proposed scheme performs with different number of clients (i.e., 4, 6, 8, and 10). Results are shown in Figure 10 for
Bandwidth reduction
In this chapter, the approach for improving bandwidth in the last mile wireless broadcast network using network coding was investigated theoretically and practically. We have evaluated the performance of our approach for video-streaming services, such as IPTV, by designing and implementing a specific system solution, for a lossy wireless scenario. Our proposed schemes combine different lost packets from different clients in such a way that all clients are able to recover their lost packets with one transmission by the server. In particular, network coding is used to code and decode packets, as the new way of transmitting packets through the network. Instead of just store-and-forward technique, the server is now able to code packets in a more clever way, and transmit them over the broadcast network.
\nThe implementation of such architecture, in a real scenario, was shown to be feasible. We tested the proposed approach with two different scenarios. It was found that the proposed approach in both cases decreases the number of transmitted packets. As compared to traditional unicast retransmission approach, where every packet is retransmitted separately, the reduction in bandwidth using the proposed network coding assisted retransmission scheme was up to 15%. This is a significant result and the developed scheme should be of great interest to be implemented in throughput demanding systems. In addition, results show that proposed approach saves bandwidth in various situations where users have different terminal equipment and different link quality. We observed the highest gains with high number of clients (i.e., 10 clients), which is also the case in the envisioned application where even higher number of different concurrent streams is anticipated.
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\n\nIf you do not receive your order within 30 days from the date your order is shipped, please contact us to inquire about the shipping status at orders@intechopen.com.
\n\nTax: Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.
\n\nCustoms: free shipping does not include any duties, taxes or clearing charges levied by the destination country. These charges are the responsibility of the customer and will vary from country to country.
\n\nP.O. Boxes cannot be used as a Ship-To Address.
\n\nIntechOpen partners do not provide shipping service from Europe to the countries listed below. Please refrain from mailing items addressed to the countries listed below, until further notice.
\n\nWhen ordering our books from the countries listed below, please provide an alternative mailing address. For any further assistance, please contact us at orders@intechopen.com.
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\n\nPOD products are non-returnable and non-refundable, except in the event of poor print quality or an error in quantity. If we delivered the item to you in error or the item is faulty, please contact us.
\n\nInspect your order carefully when it arrives. Any problems should be immediately reported to orders@intechopen.com.
\n\nPrint copies of our publications are most often purchased by universities, libraries, institutions and academia personnel, hence increasing the visibility and outreach of our authors' published work among science communities and institutions.
\n\nOur books are available at our direct Print Sales Department and through selected representatives throughout the world.
\n\nBooks International
\n\nRepresentative for: Brunei, Cambodia, Indonesia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam (ASEAN)
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\n\nRepresentative for: China, Taiwan, Hong Kong
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\n\nRepresentative for: India, Bangladesh, Pakistan, Sri Lanka, Bhutan, Nepal, Maldives, Iran, Algeria, Bahrain, Egypt, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Malta, Morocco, Oman, Qatar, Saudi Arabia, Syria, Tunis, United Arab Emirates and Yemen
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Ebirim, Omiepirisa Yvonne Buowari and Subhamay Ghosh",authors:[{id:"49582",title:"Mr.",name:"Subhamay",middleName:null,surname:"Ghosh",slug:"subhamay-ghosh",fullName:"Subhamay Ghosh"},{id:"151696",title:"Dr.",name:"Dabota Yvonne",middleName:"Yvonne",surname:"Buowari",slug:"dabota-yvonne-buowari",fullName:"Dabota Yvonne Buowari"}]},{id:"46303",doi:"10.5772/57401",title:"Multimodal Analgesia for the Management of Postoperative Pain",slug:"multimodal-analgesia-for-the-management-of-postoperative-pain",totalDownloads:3435,totalCrossrefCites:5,totalDimensionsCites:9,abstract:null,book:{id:"3850",slug:"pain-and-treatment",title:"Pain and Treatment",fullTitle:"Pain and Treatment"},signatures:"Borja Mugabure Bujedo, Silvia González Santos, Amaia Uría\nAzpiazu, Anxo Rubín Noriega, David García Salazar and Manuel\nAzkona Andueza",authors:[{id:"169676",title:"Dr.",name:"Borja Mugabure",middleName:null,surname:"Bujedo",slug:"borja-mugabure-bujedo",fullName:"Borja Mugabure Bujedo"},{id:"170333",title:"Dr.",name:"Silvia",middleName:null,surname:"Gonzalez Santos",slug:"silvia-gonzalez-santos",fullName:"Silvia Gonzalez Santos"},{id:"170334",title:"Dr.",name:"Amaia",middleName:"Uria",surname:"Azpiazu",slug:"amaia-azpiazu",fullName:"Amaia Azpiazu"},{id:"170335",title:"Dr.",name:"Anxo",middleName:null,surname:"Rubin Noriega",slug:"anxo-rubin-noriega",fullName:"Anxo Rubin Noriega"},{id:"170336",title:"Dr.",name:"David",middleName:null,surname:"Garcia Salazar",slug:"david-garcia-salazar",fullName:"David Garcia Salazar"},{id:"170337",title:"Dr.",name:"Manuel",middleName:null,surname:"AZCONA ANDUEZA",slug:"manuel-azcona-andueza",fullName:"Manuel AZCONA ANDUEZA"}]},{id:"62969",doi:"10.5772/intechopen.79689",title:"Non-Pharmacological Pain Management",slug:"non-pharmacological-pain-management",totalDownloads:2930,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Non-pharmacological pain therapy refers to interventions that do not involve the use of medications to treat pain. The goals of non-pharmacological interventions are to decrease fear, distress and anxiety, and to reduce pain and provide patients with a sense of control. When deciding the most effective non-pharmacological technique, take into consideration the patient’s age, developmental level, medical history and prior experiences, current degree of pain and/or anticipated pain. The advantage of non-pharmacological treatments is that they are relatively inexpensive and safe.",book:{id:"7289",slug:"pain-management-in-special-circumstances",title:"Pain Management in Special Circumstances",fullTitle:"Pain Management in Special Circumstances"},signatures:"Ahmed El Geziry, Yasser Toble, Fathi Al Kadhi, Muhammad Pervaiz\nand Mohammad Al Nobani",authors:null},{id:"40388",doi:"10.5772/51086",title:"Autonomic Regulation in Musculoskeletal Pain",slug:"autonomic-regulation-in-musculoskeletal-pain",totalDownloads:4231,totalCrossrefCites:1,totalDimensionsCites:7,abstract:null,book:{id:"2238",slug:"pain-in-perspective",title:"Pain in Perspective",fullTitle:"Pain in Perspective"},signatures:"David M. Hallman and Eugene Lyskov",authors:[{id:"142718",title:"Ph.D. Student",name:"David",middleName:"Michael",surname:"Hallman",slug:"david-hallman",fullName:"David Hallman"},{id:"148936",title:"Dr.",name:"Eugene",middleName:null,surname:"Lyskov",slug:"eugene-lyskov",fullName:"Eugene Lyskov"}]}],mostDownloadedChaptersLast30Days:[{id:"62969",title:"Non-Pharmacological Pain Management",slug:"non-pharmacological-pain-management",totalDownloads:2922,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Non-pharmacological pain therapy refers to interventions that do not involve the use of medications to treat pain. The goals of non-pharmacological interventions are to decrease fear, distress and anxiety, and to reduce pain and provide patients with a sense of control. When deciding the most effective non-pharmacological technique, take into consideration the patient’s age, developmental level, medical history and prior experiences, current degree of pain and/or anticipated pain. The advantage of non-pharmacological treatments is that they are relatively inexpensive and safe.",book:{id:"7289",slug:"pain-management-in-special-circumstances",title:"Pain Management in Special Circumstances",fullTitle:"Pain Management in Special Circumstances"},signatures:"Ahmed El Geziry, Yasser Toble, Fathi Al Kadhi, Muhammad Pervaiz\nand Mohammad Al Nobani",authors:null},{id:"73348",title:"The Role of Cupping Therapy in Pain Management: A Literature Review",slug:"the-role-of-cupping-therapy-in-pain-management-a-literature-review",totalDownloads:1023,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Cupping therapy is an ancient method which has been used for centuries for various painful conditions. It is performed by applying cups to selected skin points most commonly in the back aiming to create areas of sub-atmospheric pressure. It has been classified as either dry or wet type of therapy. Its mechanism of action is not well understood but several proposed mechanisms are described in the literature. It is relatively safe with a few reported side effects which include scar formation and skin infection. In this paper, a review of the literature will be presented to determine its potential benefits in pain management particularly in musculo-skeletal conditions such as low back and neck pain.",book:{id:"9483",slug:"pain-management-practices-novel-therapies-and-bioactives",title:"Pain Management",fullTitle:"Pain Management - Practices, Novel Therapies and Bioactives"},signatures:"Asma Al-Shidhani and Abdulaziz Al-Mahrezi",authors:[{id:"248467",title:"Dr.",name:"Abdulaziz",middleName:null,surname:"Al-Mahrezi",slug:"abdulaziz-al-mahrezi",fullName:"Abdulaziz Al-Mahrezi"},{id:"322652",title:"Dr.",name:"Asma",middleName:null,surname:"Al-Shidhani",slug:"asma-al-shidhani",fullName:"Asma Al-Shidhani"}]},{id:"63560",title:"Pain Management for the Sickle Cell Patient",slug:"pain-management-for-the-sickle-cell-patient",totalDownloads:1160,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Sickle cell disease (SCD) is a condition very common in the United States of America and its most common presenting symptom is pain related to vaso-occlusive events (VOE). The cost associated with healthcare for the sickle cell population exceeds 1 billion $USD yearly, and the majority of this cost is associated with admission related to vaso-occlusive events. With the increase longevity of patients with SCD, due to new therapies and vaccination against common infection related to SCD, the prevalence of older individuals experiencing VOE will likely increase. The psychological impact inflicted on patients with SCD can further complicate adequate care of patients experiencing acute or chronic pain and the latter must be taken into consideration when planning an optimal treatment regimen. This chapter reviews the short- and long-term management options of pain related to VOE, their limitations as well proposed regimen that could pave the way for the future of pain management of SCD.",book:{id:"7289",slug:"pain-management-in-special-circumstances",title:"Pain Management in Special Circumstances",fullTitle:"Pain Management in Special Circumstances"},signatures:"Thomas Zouki, Armen Haroutunian and Tennison Malcolm",authors:null},{id:"62009",title:"Acute Pain Management in Intensive Care Patients: Facts and Figures",slug:"acute-pain-management-in-intensive-care-patients-facts-and-figures",totalDownloads:1737,totalCrossrefCites:4,totalDimensionsCites:3,abstract:"Pain is an unpleasant experience for all patients including intensive care patients; if it is not treated properly, it has deleterious effects on patients’ acute and chronic well-beings. In ICU patients, it causes sympathetic stimulation leading to adverse hemodynamic effects and after discharge, these patients are at the higher risk for developing chronic pain and post-traumatic stress disorders. Apart from racial and regional factors, sleep deprivation, anxiety, and delirium increase the pain perceptions. Pain assessment is a prerequisite for adequate pain management. The ICU patients are sedated and ventilated, and assessment scales differ depending on whether the patient is able to communicate. There are different pain assessment scales for both groups of patients. The preferred mode of delivery of analgesic medication is intravenous route as intramuscular and subcutaneous route are not reliable for drug delivery in these patients. Patient and nurse controlled analgesia gives better sense of pain control. In the treatment of pain, opioids are the commonly used medications, but paracetamol, dexmedetomidine, and gabapentin are increasingly used. Newer trends are multimodal analgesia, where the combinations of analgesic medications with different mechanism of action are used. Another trend is increasing use of analgosedation; they not only control the pain but also relieve anxiety.",book:{id:"7289",slug:"pain-management-in-special-circumstances",title:"Pain Management in Special Circumstances",fullTitle:"Pain Management in Special Circumstances"},signatures:"Nissar Shaikh, Saher Tahseen, Qazi Zeesan Ul Haq, Gamal Al-Ameri,\nAdel Ganaw, Arshed Chanda, Muhammed Zubair Labathkhan and\nTariq Kazi",authors:[{id:"107703",title:"Dr.",name:"Nissar",middleName:null,surname:"Shaikh",slug:"nissar-shaikh",fullName:"Nissar Shaikh"}]},{id:"66349",title:"Food-Derived Opioids: Production and the Effects of Opioids on Human Health",slug:"food-derived-opioids-production-and-the-effects-of-opioids-on-human-health",totalDownloads:1393,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Traditional opioids have been used for the people who suffer from cancer, burns, surgery, HIV/AIDS, and other serious illness pains for years. However, numerous side effects like dizziness, apnea, physical dependence, tolerance, addiction, nausea, and vomiting push the researchers to look forward to the new opioid options. The opioid peptides which derived from foods provide significant advantages as the safe and natural alternative. The researchers reported that it is also promising a new functional food and nutraceutical. In this chapter, the type of food-derived opioids, their origins, possible receptors, their amino acid sequences, opioid effects, production techniques, and health benefits are reviewed.",book:{id:"7897",slug:"from-conventional-to-innovative-approaches-for-pain-treatment",title:"From Conventional to Innovative Approaches for Pain Treatment",fullTitle:"From Conventional to Innovative Approaches for Pain Treatment"},signatures:"Sevda Arısoy, Işık Çoban and Özlem Üstün-Aytekin",authors:[{id:"280072",title:"Dr.",name:"Özlem",middleName:null,surname:"Aytekin",slug:"ozlem-aytekin",fullName:"Özlem Aytekin"},{id:"280074",title:"Ph.D. Student",name:"Sevda",middleName:null,surname:"Arısoy",slug:"sevda-arisoy",fullName:"Sevda Arısoy"},{id:"299161",title:"Dr.",name:"Işık",middleName:null,surname:"Çoban",slug:"isik-coban",fullName:"Işık Çoban"}]}],onlineFirstChaptersFilter:{topicId:"1116",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:17,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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